Effects of parathyroid hormone and calcitonin on calcium transport of rat cultured striatum cells.

Abstract

The effects of human parathyroid hormone (hPTH 1-34) and calcitonin on Ca2+ transport in resting and KCl-depolarized cultured cells of rat striatum were studied. The results showed that in resting cells PTH significantly increased both Ca2+ uptake and efflux, while calcitonin had no effect on either. In KCl-depolarized cells the Ca2+ uptake was increased by PTH and reduced by calcitonin, and the effluxes were reduced by both PTH and calcitonin. These results suggest that the two hormones may alter the functions of neurons by regulating cytoplasmic Ca2+ levels.