多菌性麻风患者三年多药治疗的疗效。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

W Li, G Ye, Z Yang, M Tao, J Luo, C Wang, F Ji

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摘要

本文报道了1983-1986年扬州市和东台县多菌性麻风患者应用利福平(RFP)、氯法齐明(B663)和氨苯砜(DDS)治疗3年的可行性和效果。两区591例活动性多菌性麻风患者中，569例(96.30%)采用该方案治疗。在可供分析的303例病例中，196例(64.7%)表现为皮肤涂片阴性和临床不活动。其余的人表现出不同程度的改善。BI平均降低0.78。ENL和神经炎的强度和频率随治疗显著降低。主要的副作用是皮肤色素沉着和鱼鳞样改变，但这些不影响治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of three-year multidrug therapy in multibacillary leprosy patients.

The feasibility and effects of a 3-year treatment using rifampicin (RFP), clofazimine (B663) and dapsone (DDS) in multibacillary leprosy patients in Yangzhou Prefecture and Dongtai County (1983-1986) are reported. Among 591 active multibacillary leprosy patients in the two areas, 569 (96.30%) were treated with this regimen. Of 303 cases available for analysis, 196 (64.7%) cases showed negative skin smears and clinical inactivity. The rest showed different degrees of improvement. The average reduction of BI was 0.78. The intensity and frequency of ENL and neuritis decreased markedly with treatment. The main side-effects were pigmentation and ichthyosiform changes of the skin, but these did not influence treatment.

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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

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