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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao最新文献

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Establishment of a human B cell line that responds specifically to B cell growth factor. 建立对B细胞生长因子有特异性反应的人B细胞系。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
L P Zhu, L Shi, D I Zheng, B C Guo, X Wang, S Z Zhang
{"title":"Establishment of a human B cell line that responds specifically to B cell growth factor.","authors":"L P Zhu,&nbsp;L Shi,&nbsp;D I Zheng,&nbsp;B C Guo,&nbsp;X Wang,&nbsp;S Z Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A human B cell line (3D5) that responds specifically to B cell growth factor (BCGF) has been developed by a sequence of Staphylococcus aureus Cowen I activation, EB virus immortalization, and cloning. Proliferative response to PHA-stimulated T cell supernatant (PHA-T-Sup) and nonresponsiveness to rIL-2 stimulation were factors used to screen positive cells. Phenotype analysis with a flow cytometer indicated that: 1) 3D5 is a B cell line: 100% of the cells were positive for B1 marker and 59% were positive for sIg, while T3 and Mo 1 were negative; 2) 3D5 is an activated B cell line: both Tac and 4F2 markers of activated (but not of resting) B cells were 100% positive; 3) 3D5 expresses high molecular weight BCGF (HMW-BCGF) receptor-associated epitope BA5. 3D5 cells proliferated in response to cpBCGF stimulation in a dose-dependent manner. HMW-BCGF also induced 3D5 cells to proliferate. Interestingly, no proliferation could be detected in the presence of rIL-2, rIL-4, or rIFN-r. The data show that 3D5 cells are specifically BCGF-responsive B cells. Using 3D5 cells as target, BCGF activity was detected in crude BCGF preparation sedimented by 85% (NH4)2SO4 and chromatographed in a DEAE-Sephadex A-25 column from PHA-T-Sup. T24 cell supernatant with B cell differentiation factor (BCDF) activity could not induce 3D5 cells to differentiate into immunoglobulin-secreting cells.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 2","pages":"69-74"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13395804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parathyroid gland allotransplantation in rats using a nude mouse interim host system. 大鼠甲状旁腺异体移植裸鼠临时宿主系统。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
X He, Y Zhu
{"title":"Parathyroid gland allotransplantation in rats using a nude mouse interim host system.","authors":"X He,&nbsp;Y Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Donor rat parathyroid gland (PTG) was first transplanted into the nude mouse interim host system. After 100 days the PTG was re-transplanted into eligible recipients. The results show that mean survival time of recipient rats may be remarkably prolonged.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 1","pages":"41-2"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13522074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of hemolytic disease of the newborn caused by anti-Hro and anti-e. 抗hro和抗e致新生儿溶血病1例。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
Y Diao, N Song, Z Guan, L Zhang, Y Wang, M Wan
{"title":"A case of hemolytic disease of the newborn caused by anti-Hro and anti-e.","authors":"Y Diao,&nbsp;N Song,&nbsp;Z Guan,&nbsp;L Zhang,&nbsp;Y Wang,&nbsp;M Wan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A Chinese woman of blood group B, D- and her husband of blood group AB, CCDee were examined. The woman had not been transfused before. Their first two babies died. Anti-Hro and anti-e were found in the mother's serum. During her third pregnancy, the titer of antibodies went up quickly, approximately one titer per month. After 36 weeks of pregnancy, the baby was delivered by Caesarean section. The cord blood Hb was 88 g/L, his red blood cell count 2.7 x 10(12)/L, and total bilirubin 114.6 mol/L. The baby was of blood group AB, and CDe-D-genotype. Exchange transfusion was begun 2.5 hours after birth. O, ccDEE washed red cells together with group AB plasma were used. Two days later, 70 ml washed O, ccDEE concentrated red cells were administered. The baby is alive and in good health.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 1","pages":"58-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13522077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the application of least-squares refinement to complex structures--resolving enantiomorphous phase ambiguity. 最小二乘改进在复杂结构中的应用——解决对映纯相位模糊。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
C He, Q Zheng
{"title":"On the application of least-squares refinement to complex structures--resolving enantiomorphous phase ambiguity.","authors":"C He,&nbsp;Q Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A least-squares refinement procedure has been proposed for resolving enantiomorphous ambiguity of noncentrosymmetric structures containing heavy atoms in a centrosymmetric arrangement. During the least-squares refinement of a pseudo-centrosymmetric image containing both enantiomorphs, the temperature factors of atoms in one enantiomorph shift in the same direction, while those of the other shift in the opposite direction. Accordingly the true structure can be distinguished easily from its enantiomorph. Tests on four unknown structures have shown that the method is very powerful.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 2","pages":"61-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13395590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S100 protein-positive dendritic cells and the significance of their density in gastric precancerous lesions. 胃癌前病变中S100蛋白阳性树突状细胞及其密度的意义。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
J A Huang, H D Huang, Q B Peng, Z J Zhu, X R Yu
{"title":"S100 protein-positive dendritic cells and the significance of their density in gastric precancerous lesions.","authors":"J A Huang,&nbsp;H D Huang,&nbsp;Q B Peng,&nbsp;Z J Zhu,&nbsp;X R Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Quantitative analysis of dendritic cells (DC's) was carried out in tissue specimens of normal gastric mucosa (n = 15), gastric ulcer (n = 19), chronic atrophic gastritis (n = 28), and gastric carcinoma (n = 65) by ABC immunostaining with S100 protein antibody. Significant increases in DC number were observed in chronic atrophic gastritis with type III intestinal metaplasia and/or grade II, III dysplasia. The result suggests that DC's are potentially capable of presenting neoantigens associated with malignant transformation at the precancerous stage when malignant morphological changes have not yet taken place. Combined with routine diagnostic methods, the serial monitoring of DC density in gastric mucosa may be useful in the follow-up of premalignant lesions in the stomach and the diagnosis of early gastric carcinoma.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 2","pages":"93-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13395808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the relationship between chromosome No15 and the biological characteristics of malignant transformed Syrian hamster fibroblast cell lines. 叙利亚仓鼠恶性转化成纤维细胞细胞系15号染色体与生物学特性关系的研究。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
S Li, B Liu, D Xu
{"title":"Studies on the relationship between chromosome No15 and the biological characteristics of malignant transformed Syrian hamster fibroblast cell lines.","authors":"S Li,&nbsp;B Liu,&nbsp;D Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the course of malignant transformation of mammalian cells in vitro, a regular variation in chromosome number and structure is usually found. In order to elucidate the relationship between chromosomal changes and malignant expression, we isolated five clones from a malignant transformed Syrian hamster fibroblast cell line and analysed their biological characteristics, as well as chromosomal changes. A positive correlation between chromosome No 15 monosomy and the transformed and malignant phenotype was observed. We suggest that a suppression gene may be located on chromosome No 15, and its deletion or the loss of the chromosome may result in expression of the malignant phenotype.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 1","pages":"43-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13522075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical considerations of re-do valve replacement. 再做瓣膜置换术的外科考虑。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
X Zhu, J Guo, M Xiao, C Tang
{"title":"Surgical considerations of re-do valve replacement.","authors":"X Zhu,&nbsp;J Guo,&nbsp;M Xiao,&nbsp;C Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Between August 1976 and May 1988, 43 patients had their heart valve prostheses replaced. The total mortality was as high as 25.6%, but the operative mortality was reduced to 6.25% in the last 16 cases. The indications, main risk factors and surgical techniques are discussed.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13519843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary lymphoma of the lung. 原发性肺淋巴瘤。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
Z Zhang, H Liu, C Shun, H Yu
{"title":"Primary lymphoma of the lung.","authors":"Z Zhang,&nbsp;H Liu,&nbsp;C Shun,&nbsp;H Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two cases of primary lymphoma of the lung are reported, both of which were misdiagnosed preoperatively as bronchogenic carcinoma before undergoing successful resection. Accurate diagnosis was obtained after operation. These two patients were in good condition after a short period of follow-up. A discussion is presented concerning diagnosis, treatment and prognosis. Also, we point out the reason why so few primary lymphomas of the lung are reported: the mass of the lymphoma is typically so large that surgeons may consider it to be lung cancer in a late stage and thus abandon surgical intervention, or it may be erroneously diagnosed pathologically as undifferentiated small cell carcinoma of the lung.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 3","pages":"168-71"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13254536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cigánek's rhythm--prolonged observations with report of a case. Cigánek的节奏——长时间的观察和病例报告。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
Y Feng
{"title":"Cigánek's rhythm--prolonged observations with report of a case.","authors":"Y Feng","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 3","pages":"176-80"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13254538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging techniques for the diagnosis of renal tumors. 肾肿瘤的影像学诊断技术。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01
F L Gu
{"title":"Imaging techniques for the diagnosis of renal tumors.","authors":"F L Gu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, diagnostic imaging techniques, especially ultrasonography (US) and CT scanning, have been widely adopted in clinical practice, making early accurate diagnosis of renal tumors possible. A total of 452 cases of renal tumors have been admitted to the institute since 1951, of which 220 were seen from 1951 to 1979 and 232 in the past 9 years (1980-1988). The frequency of renal parenchymal tumors was obviously higher in the latter group, including asymptomatic renal carcinoma in 20.2% and hamartoma in 38.1%. All these were discovered on routine physical check-up by ultrasonography and/or CT scanning and would otherwise have gone undiagnosed on conventional urography. Ultrasonography and CT can also reveal the nature and the extent of the tumor. The idea that \"a renal tumor should be considered malignant unless pathologically proven otherwise\" is no longer valid. However, general manifestations of renal carcinoma, such as elevated erythrocyte sedimentation rate (ESR), hypertension, malaise, anemia, fever and hypercalcemia, still deserve proper attention. We suggest that ultrasonography of both kidneys should be mandatory in routine physical check-up, as far as the urinary system is concerned, in order to discover asymptomatic renal tumors.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 2","pages":"75-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13395805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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