Yingjian Shi (, ), Xin Huang (, ), Wentao Zhao (, ), Xingxing Li (, ), Haoran Wang (, ), Hao Zhu (, ), Kangkang Niu (, ), Wei Han (, ), Jun Zhang (, ), Li Tao (, ), Hao Wang (, )
{"title":"Boosting interface band alignment via synergistic supercritical fluid post-treatment and SAM functionalization for Ga2O3-hybrid solar-blind detectors","authors":"Yingjian Shi \u0000 (, ), Xin Huang \u0000 (, ), Wentao Zhao \u0000 (, ), Xingxing Li \u0000 (, ), Haoran Wang \u0000 (, ), Hao Zhu \u0000 (, ), Kangkang Niu \u0000 (, ), Wei Han \u0000 (, ), Jun Zhang \u0000 (, ), Li Tao \u0000 (, ), Hao Wang \u0000 (, )","doi":"10.1007/s40843-026-4131-3","DOIUrl":"10.1007/s40843-026-4131-3","url":null,"abstract":"<div><p>p-n heterojunction solar-blind photodetectors, based on p-type materials and n-type Ga<sub>2</sub>O<sub>3</sub>, have attracted significant attention in the optoelectronics field due to their inherent low dark current and self-powered operation. Among various constructions, organic-inorganic hybrid heterojunctions formed by integrating p-type organic materials with n-type Ga<sub>2</sub>O<sub>3</sub> offer a promising solution to overcome the lattice mismatch, opening new avenues for device performance breakthroughs. In this work, the Ga<sub>2</sub>O<sub>3</sub> thin films are treated via a supercritical fluid technique (SC), which significantly reduced defect state density while improving crystallinity and surface uniformity of films, thereby laying a crucial foundation for heterojunction interface optimization. Simultaneously, a self-assembled monolayer (SAM) was introduced at the organic-inorganic heterojunction interface. Notably, the high-quality Ga<sub>2</sub>O<sub>3</sub> surface engineered via the supercritical fluid treatment facilitated the highly efficient, oriented self-assembly of SAM molecules, enabling precise modulation of the interfacial energy band alignment and promoting the separation and transport dynamics of photogenerated carriers. Benefiting from the synergistic effects of supercritical fluid modification and SAM functionalization, the fabricated solar-blind photodetector achieves a highest responsivity of 111.7 mA/W and a specific detectivity of 1.02 × 10<sup>11</sup> Jones under zero bias (self-powered mode) and weak 254 nm light with an intensity of 5 µW/cm<sup>2</sup>.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 9","pages":"5736 - 5747"},"PeriodicalIF":7.7,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chuying Li (, ), Yanwei He (, ), Jiahui Liu (, ), Huifa Meng (, ), Xueyi Yu (, ), Xiaoying Xing (, ), Xing Kang (, ), Yinghua Sha (, ), Kaijin Chen (, ), Yanming Chen (, ), Siwei Liu (, ), Ying Shi (, ), Yi Zhang (, )
{"title":"High expansion ratio polyimide foam prepared by sCO2 process through precise control of molecular weight between cross-link points","authors":"Chuying Li \u0000 (, ), Yanwei He \u0000 (, ), Jiahui Liu \u0000 (, ), Huifa Meng \u0000 (, ), Xueyi Yu \u0000 (, ), Xiaoying Xing \u0000 (, ), Xing Kang \u0000 (, ), Yinghua Sha \u0000 (, ), Kaijin Chen \u0000 (, ), Yanming Chen \u0000 (, ), Siwei Liu \u0000 (, ), Ying Shi \u0000 (, ), Yi Zhang \u0000 (, )","doi":"10.1007/s40843-026-4156-8","DOIUrl":"10.1007/s40843-026-4156-8","url":null,"abstract":"<div><p>Supercritical carbon dioxide (sCO<sub>2</sub>) foaming offers a green and efficient route to fabricate high-performance polyimide (PI) foams, which are coveted for their exceptional thermal stability and intrinsic flame retardancy in advanced fields. However, the high glass transition temperature and low melt strength of PIs present significant challenges, leading to a narrow foaming window, poor cell formation, and low expansion ratios. To address these limitations, we developed a strategy that enhances melt strength and broadens the foaming process window by constructing a controllably slightly cross-linked network in polyimides via precise molecular weight modulation of a maleic anhydride-terminated network precursor. By designing and synthesizing this precursor with molecular weight regulated by feeding ratios, and subsequently inducing thermal crosslinking under hot-pressing, we systematically regulated the molecular weight between cross-link points (<i>M</i><sub>c</sub>) and obtained slightly cross-linked materials. This approach enabled the successful production of a series of PI foams via sCO<sub>2</sub> foaming process, which exhibit a broad foaming window, a homogeneous cell structure, and a significantly enhanced expansion ratio (10.51)—representing a 6.11-fold increase over the linear PI. Furthermore, the resulting slightly cross-linked polyimide foam exhibits excellent mechanical properties, thermal insulating properties, and flame-retardant properties, highlighting its broad application potential in fields requiring lightweight, high-performance materials, such as low-altitude economy and humanoid robots.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 10","pages":"6452 - 6463"},"PeriodicalIF":7.7,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149099242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiwei Zhang (, ), Xu Wang (, ), Jiayi Sun (, ), Lixia Wang (, ), Yamin Chang (, ), Junfang Wang (, ), Yongle Pan (, ), Hao Wang (, ), Ziquan Yuan (, ), Xiangyue Meng (, )
{"title":"Hydrogen-bond engineered supramolecular bismuth halides for flexible X-ray imaging without geometric distortion","authors":"Shiwei Zhang \u0000 (, ), Xu Wang \u0000 (, ), Jiayi Sun \u0000 (, ), Lixia Wang \u0000 (, ), Yamin Chang \u0000 (, ), Junfang Wang \u0000 (, ), Yongle Pan \u0000 (, ), Hao Wang \u0000 (, ), Ziquan Yuan \u0000 (, ), Xiangyue Meng \u0000 (, )","doi":"10.1007/s40843-026-4126-0","DOIUrl":"10.1007/s40843-026-4126-0","url":null,"abstract":"<div><p>The development of flexible X-ray detectors is hindered by the fundamental challenge of fabricating semiconductor films that combine uniform morphology, high crystallinity, and mechanical robustness. Here, we report a hydrogen-bond engineered supramolecular (HBES) strategy that simultaneously overcomes these limitations in supramolecular bismuth halide cluster (PDBiI<sub>5</sub>). By incorporating polyacrylic acid (PAA), we construct a dynamic supramolecular network that suppresses the coffee-ring effect during ultrasonic spray-coating by increasing solution viscosity and rationally modulating the kinetic balance between solvent evaporation and solute diffusion. Furthermore, the HBES approach modulates crystallization kinetics, prolonging the crystal growth time from 23 to 41 s and yielding densely packed films with enhanced crystallinity and significantly reduced defect states. These structural improvements endow the HBES-PDBiI<sub>5</sub> films with superior charge transport properties, including a high hole mobility of 2.16 cm<sup>2</sup> V<sup>−1</sup> s<sup>−1</sup> and an outstanding mobility-lifetime product of 9.1 × 10<sup>−4</sup> cm<sup>2</sup> V<sup>−1</sup>. Consequently, the resulting X-ray detectors achieve a record sensitivity of 19,009 µC Gy<sub>air</sub><sup>−1</sup> cm<sup>−2</sup> and an ultralow detection limit of 3.35 nGy<sub>air</sub> s<sup>−1</sup>, alongside excellent operational and environmental stability. Leveraging the mechanical robustness imparted by the dynamic supramolecular network, we demonstrate the first direct-type flexible X-ray imager, which retains 85% of its performance after 1000 bending cycles. This flexible imager effectively overcomes geometric distortion and vignetting effects, maintaining 85% edge photocurrent compared to 58% for rigid detectors, enabling clear imaging of curved objects. This work establishes a versatile supramolecular engineering paradigm for developing high-performance, flexible X-ray detection and imaging technologies.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 9","pages":"5509 - 5518"},"PeriodicalIF":7.7,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanbin Xu (, ), Mengli Liu (, ), Mengqi Zhao (, ), Mingjie Ye (, ), Yating Gao (, ), Chengye Xi (, ), Yunqing Cao (, ), Junjie Yu (, ), Mahmoud Elsayed Hafez (, ), Ruocan Qian (, ), Binbin Chen (, ), Dawei Li (, )
{"title":"A “dual lock-and-key” engineered intracellular synthesis for high-precision cancer therapy","authors":"Hanbin Xu \u0000 (, ), Mengli Liu \u0000 (, ), Mengqi Zhao \u0000 (, ), Mingjie Ye \u0000 (, ), Yating Gao \u0000 (, ), Chengye Xi \u0000 (, ), Yunqing Cao \u0000 (, ), Junjie Yu \u0000 (, ), Mahmoud Elsayed Hafez \u0000 (, ), Ruocan Qian \u0000 (, ), Binbin Chen \u0000 (, ), Dawei Li \u0000 (, )","doi":"10.1007/s40843-025-4129-y","DOIUrl":"10.1007/s40843-025-4129-y","url":null,"abstract":"<div><p>Therapeutic biosynthesis has emerged as a cutting-edge technology for precision medicine. However, achieving the highly-controlled synthesis of abiotic matter at the tumor location for efficient therapy remains an ongoing challenge. Here, we develop a “dual lock-and-key” system to accomplish tumor cell-specific intracellular synthesis for accurate cancer therapy. The proposed precursor structure (“dual-lock”) can be activated in target cancer cells by two endogenously overexpressed enzymes (“dual key”), azor-eductase (AzoR) and nitroreductase (NTR), to initiate a condensation reaction for the <i>in situ</i> synthesis of fibrous mesh covalent organic polymers (Fm-COPs). The synthesized Fm-COPs demonstrate an excellent ability to disrupt the cytoskeleton, thereby inhibiting cell migration, suppressing cell invasion, and inducing apoptosis. Importantly, by leveraging the dual enzyme-responsive mechanism and small-molecule precursors the proposed intracellular synthesis strategy performs well on specific enrichment and tumor penetration, resulting in effective inhibition of tumor proliferation without side effects. Our findings suggest that this “dual lock-and-key” engineered intracellular synthesis represents a promising next-generation option for high-precision cancer therapies.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 9","pages":"5793 - 5802"},"PeriodicalIF":7.7,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuhang Yang (, ), Jianchen Lu (, ), Ruiping Duan (, ), Guang Zhang (, ), Wei Xiong (, ), Boyu Fu (, ), Gefei Niu (, ), Shijie Sun (, ), Lei Gao (, ), Long Chen (, ), Jinming Cai (, )
{"title":"Experimental realization of mixed-dimensional 1D-graphyne-nanowires/2D-AgTe-monolayer heterostructures","authors":"Yuhang Yang \u0000 (, ), Jianchen Lu \u0000 (, ), Ruiping Duan \u0000 (, ), Guang Zhang \u0000 (, ), Wei Xiong \u0000 (, ), Boyu Fu \u0000 (, ), Gefei Niu \u0000 (, ), Shijie Sun \u0000 (, ), Lei Gao \u0000 (, ), Long Chen \u0000 (, ), Jinming Cai \u0000 (, )","doi":"10.1007/s40843-026-4114-5","DOIUrl":"10.1007/s40843-026-4114-5","url":null,"abstract":"<div><p>The precise and controllable synthesis of one-dimensional (1D) and two-dimensional (2D) heterostructures, coupled with the manipulation of their atomic and electronic configurations, is of paramount significance. However, due to the synthetic challenges associated with graphyne (GY) materials, their integration into 1D/2D heterostructures remains considerably difficult. Herein, we demonstrate a post-synthetic intercalation strategy for tellurium onto Ag(111), enabling the controllable fabrication of 1D-GY-nanowire/2D-AgTe-monolayers heterostructures. Scanning-probe microscopies are employed to characterize morphological evolution during the intercalation process. Scanning tunneling spectroscopy results confirm that AgTe monolayer intercalation induces interfacial decoupling of the graphyne nanowires. Density functional theory calculations demonstrate that work function-driven Fermi level modulation via interfacial charge engineering assigns the 1D-GY-nanowire/2D-AgTe-monolayers heterostructures as type-I heterostructures. Our work not only significantly advances the fundamental understanding of interfacial interactions in 1D/2D heterostructures but also presents a scalable strategy for designing heterostructures with tailored electronic functionalities, thereby opening new avenues for applications in advanced nanoelectronics and optoelectronic devices.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 10","pages":"6480 - 6486"},"PeriodicalIF":7.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149098990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xudong Wang (, ), Guichen Teng (, ), Xiangjian Meng (, ), Shujun Zhang (, ), Tie Lin (, ), Hao Shen (, ), Jianlu Wang (, ), Junhao Chu (, )
{"title":"Why are some special ferroelectrics immune to the depolarization field?","authors":"Xudong Wang \u0000 (, ), Guichen Teng \u0000 (, ), Xiangjian Meng \u0000 (, ), Shujun Zhang \u0000 (, ), Tie Lin \u0000 (, ), Hao Shen \u0000 (, ), Jianlu Wang \u0000 (, ), Junhao Chu \u0000 (, )","doi":"10.1007/s40843-025-4173-x","DOIUrl":"10.1007/s40843-025-4173-x","url":null,"abstract":"<div><p>Ferroelectric memory, with its promise of low power consumption, high writing speed and exceptional endurance, requires the scaling of ferroelectric films to ultrathin dimensions—often just a few atomic layers thick. However, such extreme thinning risks destabilizing or even erasing electric polarization, mainly due to the detrimental depolarization field. Remarkably, certain ferroelectrics exhibit an intrinsic immunity to this effect, as predicted theoretically and confirmed experimentally. Examples include improper ferroelectrics, hyper ferroelectrics, engineered heterostructures, and low-dimensional von der Waals ferroelectrics. This review systematically examines these unique materials, unravelling the fundamental physics behind their polarization robustness and the mechanisms enabling them to resist the depolarization field. By bridging theory with experimental advances, we aim to inspire the design of next-generation ferroelectrics capable of overcoming critical challenges encountered in practical ferroelectric memory devices.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 9","pages":"5385 - 5401"},"PeriodicalIF":7.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40843-025-4173-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingzhen Zhang (, ), Shibo Han (, ), Jianying Huang (, ), Weilong Cai (, ), Yun Hau Ng (, ), I-Wen Peter Chen (, ), Yuekun Lai (, )
{"title":"Nitrate intercalation suppresses Fe active-site dissolution in NiFe-LDH for durable industrial alkaline oxygen evolution","authors":"Yingzhen Zhang \u0000 (, ), Shibo Han \u0000 (, ), Jianying Huang \u0000 (, ), Weilong Cai \u0000 (, ), Yun Hau Ng \u0000 (, ), I-Wen Peter Chen \u0000 (, ), Yuekun Lai \u0000 (, )","doi":"10.1007/s40843-026-4167-3","DOIUrl":"10.1007/s40843-026-4167-3","url":null,"abstract":"<div><p>The practical deployment of alkaline water electrolysis (AWE) is fundamentally limited by the instability of oxygen evolution reaction (OER) catalysts caused by continuous dissolution of active metal sites under harsh operating conditions. Herein, we report a strategy for stabilizing NiFe layered double hydroxides (NiFe-LDH) via weak Brönsted base intercalation, which tunes the interlayer spacing and interfacial electronic structure. Through the intercalation of weakly basic nitrate anions (NO<sub>3</sub><sup>−</sup>), a nitrate-modified NiFe-LDH (NiFe-NO<sub>3</sub>) is constructed, which effectively suppresses Fe dissolution by stabilizing high-valence Ni/Fe species during operation. As a result, NiFe-NO<sub>3</sub> exhibits exceptional durability, maintaining stable operation at 1000 mA cm<sup>−2</sup> in 30 wt% KOH at 80 °C for over 500 h with an ultralow degradation rate of 0.04 mV·h<sup>−1</sup> (retention rate of electrochemical activity was 99.1%), representing a ∼12-fold lifetime improvement over pristine NiFe-LDH. Mechanistic studies reveal that NO<sub>3</sub><sup>−</sup> intercalation induces synergistic effects including slight interlayer expansion, electronic redistribution, and regulation of interlayer Brönsted basicity, which collectively stabilize high-valence Ni/Fe species and preserve the oxyhydroxide active phase during OER. This work demonstrates that Brönsted base intercalation provides an effective strategy to suppress active-site dissolution and offers new insights for the design of durable OER catalysts for industrial alkaline water electrolysis (AWE).</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 10","pages":"6360 - 6368"},"PeriodicalIF":7.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149098681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junying Zhang (, ), Xiaoyu Wang (, ), Xuehao Liu (, ), Jianing Cai (, ), Peipei Ma (, ), Song Bi (, ), Zhi-Ling Hou (, )
{"title":"Morphology-manipulated topological insulator Bi2Se3 nanosheets for integrated microwave absorption and thermoelectric conversion","authors":"Junying Zhang \u0000 (, ), Xiaoyu Wang \u0000 (, ), Xuehao Liu \u0000 (, ), Jianing Cai \u0000 (, ), Peipei Ma \u0000 (, ), Song Bi \u0000 (, ), Zhi-Ling Hou \u0000 (, )","doi":"10.1007/s40843-025-4222-9","DOIUrl":"10.1007/s40843-025-4222-9","url":null,"abstract":"<div><p>The widespread use of high-frequency communication technology has led to an increase in electromagnetic (EM) pollution, which is becoming an unavoidable issue. Nowadays, most studies have focused on the absorption of electromagnetic waves. The critical issue of reusing wasted electromagnetic energy has always been neglected. Moreover, miniaturization is urgent requirement in modern equipment, such as aircraft and satellites. Converting waste electromagnetic energy into direct current to power micro or nano-devices in special environments is a significant strategy to solve the problem of electromagnetic pollution and provides driving energy simultaneously. In this work, Bi<sub>2</sub>Se<sub>3</sub> nanosheets with controlled morphology were prepared by the polyol reduction method. The thickness and size of Bi<sub>2</sub>Se<sub>3</sub> hexagonal nanosheets were regulated by controlling preparation conditions. The corresponding Bi<sub>2</sub>Se<sub>3</sub> composites exhibit excellent microwave absorption performance with a broadband absorption bandwidth of 2.95 GHz at sub-millimeter thickness. Moreover, full-band absorption from 2 to 18 GHz is realized with multilayered structure design, which can be realized using only a single absorbent. The Seebeck coefficient obtained by fitting the temperature difference within the range of 0 to 110 °C is −152 µV/K. The results imply that Bi<sub>2</sub>Se<sub>3</sub> nanomaterials can be utilized for the conversion from absorbed electromagnetic energy to electric energy, providing a promising solution to address the EM pollution and energy supply issues of self-powered electromagnetic devices.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 9","pages":"5728 - 5735"},"PeriodicalIF":7.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yun Zheng (, ), Huilan He (, ), Yuwei Peng (, ), Chunlian Ye (, ), Jinlong Ji (, ), Xiaotong Kong (, ), Ying Zhang (, ), Zhiyuan Zhong (, )
{"title":"Multi-immunogenic bioadhesive chitosan-lecithin-podophyllotoxin nanoparticles elicit robust systemic anticancer immunity","authors":"Yun Zheng \u0000 (, ), Huilan He \u0000 (, ), Yuwei Peng \u0000 (, ), Chunlian Ye \u0000 (, ), Jinlong Ji \u0000 (, ), Xiaotong Kong \u0000 (, ), Ying Zhang \u0000 (, ), Zhiyuan Zhong \u0000 (, )","doi":"10.1007/s40843-026-4152-4","DOIUrl":"10.1007/s40843-026-4152-4","url":null,"abstract":"<div><p>Chemotherapy-induced immunogenic cell death represents a powerful mechanism to prime systemic antitumor immunity. However, the therapeutic efficacy of conventional chemo-immunotherapies is typically compromised by challenges such as transient immune activation and rapid drug clearance from the tumor site. Herein, we developed chitosan-derived macromolecular immune agonist-functionalized lecithin-podophyllotoxin nanoparticles (CLP-NPs). Unlike traditional inert delivery vehicles, this platform uniquely integrates multivalent agonism with superior bioadhesion, thereby enabling adhesion-mediated retention and sustained multi-engagement with pattern-recognition receptors. By spatiotemporally synchronizing local immunogenic cell death with persistent immune stimulation, this platform effectively converts localized chemotherapy into a robust systemic anticancer immune response. Notably, in a murine MC38 colorectal cancer model, the synergistic combination of CLP-NPs and anti-PD-1 checkpoint blockade therapy elicited a complete regression rate of 83.3% and established potent and long-term immunological memory against tumor recurrence. These findings establish CLP-NPs as a versatile nano-strategy that bridges local cytotoxicity with systemic immune priming, offering a promising translational framework for next-generation chemo-immunotherapies.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 10","pages":"6518 - 6529"},"PeriodicalIF":7.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149098837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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