具有微环境调节和血管生成功能的双动态交联心脏修复水凝胶

IF 7.4 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Haitao Zhang  (, ), Lei Liang  (, ), Zhiwei Yue  (, ), Chengyao Wang  (, ), Linyu Chen  (, ), Jiajun Lu  (, ), Hong Zhang  (, ), Fanglian Yao  (, ), Hong Sun  (, ), Junjie Li  (, )
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引用次数: 0

摘要

炎症和缺血微环境是心脏修复的重要挑战。为了解决这些问题,我们开发了一系列双动态交联海藻酸盐水凝胶(SA-PBA/E/Sr),其中含有锶离子(Sr2+)和表没食子儿茶素没食子酸酯(EGCG),它们在心肌梗死(MI)微环境中显示出微环境调节和血管生成能力。在SA-PBA/E/Sr水凝胶体系中,合成了氨基苯基硼酸修饰海藻酸盐,与EGCG形成硼酸酯键,并与Sr2+离子形成离子配位网络。所制得的水凝胶由于具有双动态交联结构,具有良好的注射性,其形成和力学性能可由PBA取代度、EGCG浓度和Sr2+含量调节。EGCG的掺入使水凝胶能够有效地清除活性氧(ROS),减轻缺氧条件下氧化应激诱导的细胞损伤。此外,Sr2+的引入显著增强了内皮细胞的迁移能力,这是血管生成的关键因素。体内实验表明,SD大鼠梗死心肌注射SA-PBA/E/Sr水凝胶可降低ROS水平,减轻炎症反应,抑制促炎M1巨噬细胞表达,增强抗炎M2巨噬细胞表达,加速损伤组织新生血管的形成。超声心动图和组织学分析显示射血分数显著增加,梗死面积减小,表明心功能明显恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A dual-dynamically crosslinked hydrogel for cardiac repair with microenvironment regulation and angiogenic functions

Inflammation and ischemic microenvironments represent significant challenges in cardiac repair. To address these issues, we developed a series of dual-dynamically crosslinked alginate-based hydrogels (SA-PBA/E/Sr) containing strontium ions (Sr2+) and epigallocatechin gallate (EGCG), which demonstrate microenvironment modulation and angiogenic capabilities in the myocardial infarction (MI) microenvironment. In the SA-PBA/E/Sr hydrogel system, alginate modified with aminophenylboronic acid (PBA) was synthesized to form boronic acid ester bonds with EGCG and an ionic coordination network with Sr2+ ions. The resulting hydrogel exhibits excellent injectability due to its dual-dynamically crosslinked structure, with its formation and mechanical properties being tunable modulated by the PBA substitution degree, EGCG concentration, and Sr2+ content. The incorporation of EGCG enables the hydrogel to efficiently scavenge reactive oxygen species (ROS) and mitigate oxidative stress-induced cellular damage under hypoxia. Furthermore, the introduction of Sr2+ significantly enhances the migratory capacity of endothelial cells, a critical factor in angiogenesis. In vivo experiments revealed that the injection of SA-PBA/E/Sr hydrogel into the infarcted myocardium of Sprague-Dawley (SD) rats led to reduced ROS levels, alleviated inflammatory responses, suppression of pro-inflammatory M1 macrophage expression, enhancement of anti-inflammatory M2 macrophage expression, and accelerated neovascularization in the damaged tissue. Echocardiographic and histological analyses demonstrated a remarkable increase in ejection fraction and a decreased infarct size, collectively indicating significant cardiac functional recovery.

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来源期刊
Science China Materials
Science China Materials Materials Science-General Materials Science
CiteScore
11.40
自引率
7.40%
发文量
949
期刊介绍: Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.
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