Haitao Zhang
(, ), Lei Liang
(, ), Zhiwei Yue
(, ), Chengyao Wang
(, ), Linyu Chen
(, ), Jiajun Lu
(, ), Hong Zhang
(, ), Fanglian Yao
(, ), Hong Sun
(, ), Junjie Li
(, )
{"title":"具有微环境调节和血管生成功能的双动态交联心脏修复水凝胶","authors":"Haitao Zhang \n (, ), Lei Liang \n (, ), Zhiwei Yue \n (, ), Chengyao Wang \n (, ), Linyu Chen \n (, ), Jiajun Lu \n (, ), Hong Zhang \n (, ), Fanglian Yao \n (, ), Hong Sun \n (, ), Junjie Li \n (, )","doi":"10.1007/s40843-025-3619-1","DOIUrl":null,"url":null,"abstract":"<div><p>Inflammation and ischemic microenvironments represent significant challenges in cardiac repair. To address these issues, we developed a series of dual-dynamically crosslinked alginate-based hydrogels (SA-PBA/E/Sr) containing strontium ions (Sr<sup>2+</sup>) and epigallocatechin gallate (EGCG), which demonstrate microenvironment modulation and angiogenic capabilities in the myocardial infarction (MI) microenvironment. In the SA-PBA/E/Sr hydrogel system, alginate modified with aminophenylboronic acid (PBA) was synthesized to form boronic acid ester bonds with EGCG and an ionic coordination network with Sr<sup>2+</sup> ions. The resulting hydrogel exhibits excellent injectability due to its dual-dynamically crosslinked structure, with its formation and mechanical properties being tunable modulated by the PBA substitution degree, EGCG concentration, and Sr<sup>2+</sup> content. The incorporation of EGCG enables the hydrogel to efficiently scavenge reactive oxygen species (ROS) and mitigate oxidative stress-induced cellular damage under hypoxia. Furthermore, the introduction of Sr<sup>2+</sup> significantly enhances the migratory capacity of endothelial cells, a critical factor in angiogenesis. <i>In vivo</i> experiments revealed that the injection of SA-PBA/E/Sr hydrogel into the infarcted myocardium of Sprague-Dawley (SD) rats led to reduced ROS levels, alleviated inflammatory responses, suppression of pro-inflammatory M1 macrophage expression, enhancement of anti-inflammatory M2 macrophage expression, and accelerated neovascularization in the damaged tissue. Echocardiographic and histological analyses demonstrated a remarkable increase in ejection fraction and a decreased infarct size, collectively indicating significant cardiac functional recovery.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 9","pages":"3377 - 3389"},"PeriodicalIF":7.4000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A dual-dynamically crosslinked hydrogel for cardiac repair with microenvironment regulation and angiogenic functions\",\"authors\":\"Haitao Zhang \\n (, ), Lei Liang \\n (, ), Zhiwei Yue \\n (, ), Chengyao Wang \\n (, ), Linyu Chen \\n (, ), Jiajun Lu \\n (, ), Hong Zhang \\n (, ), Fanglian Yao \\n (, ), Hong Sun \\n (, ), Junjie Li \\n (, )\",\"doi\":\"10.1007/s40843-025-3619-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Inflammation and ischemic microenvironments represent significant challenges in cardiac repair. To address these issues, we developed a series of dual-dynamically crosslinked alginate-based hydrogels (SA-PBA/E/Sr) containing strontium ions (Sr<sup>2+</sup>) and epigallocatechin gallate (EGCG), which demonstrate microenvironment modulation and angiogenic capabilities in the myocardial infarction (MI) microenvironment. In the SA-PBA/E/Sr hydrogel system, alginate modified with aminophenylboronic acid (PBA) was synthesized to form boronic acid ester bonds with EGCG and an ionic coordination network with Sr<sup>2+</sup> ions. The resulting hydrogel exhibits excellent injectability due to its dual-dynamically crosslinked structure, with its formation and mechanical properties being tunable modulated by the PBA substitution degree, EGCG concentration, and Sr<sup>2+</sup> content. The incorporation of EGCG enables the hydrogel to efficiently scavenge reactive oxygen species (ROS) and mitigate oxidative stress-induced cellular damage under hypoxia. 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A dual-dynamically crosslinked hydrogel for cardiac repair with microenvironment regulation and angiogenic functions
Inflammation and ischemic microenvironments represent significant challenges in cardiac repair. To address these issues, we developed a series of dual-dynamically crosslinked alginate-based hydrogels (SA-PBA/E/Sr) containing strontium ions (Sr2+) and epigallocatechin gallate (EGCG), which demonstrate microenvironment modulation and angiogenic capabilities in the myocardial infarction (MI) microenvironment. In the SA-PBA/E/Sr hydrogel system, alginate modified with aminophenylboronic acid (PBA) was synthesized to form boronic acid ester bonds with EGCG and an ionic coordination network with Sr2+ ions. The resulting hydrogel exhibits excellent injectability due to its dual-dynamically crosslinked structure, with its formation and mechanical properties being tunable modulated by the PBA substitution degree, EGCG concentration, and Sr2+ content. The incorporation of EGCG enables the hydrogel to efficiently scavenge reactive oxygen species (ROS) and mitigate oxidative stress-induced cellular damage under hypoxia. Furthermore, the introduction of Sr2+ significantly enhances the migratory capacity of endothelial cells, a critical factor in angiogenesis. In vivo experiments revealed that the injection of SA-PBA/E/Sr hydrogel into the infarcted myocardium of Sprague-Dawley (SD) rats led to reduced ROS levels, alleviated inflammatory responses, suppression of pro-inflammatory M1 macrophage expression, enhancement of anti-inflammatory M2 macrophage expression, and accelerated neovascularization in the damaged tissue. Echocardiographic and histological analyses demonstrated a remarkable increase in ejection fraction and a decreased infarct size, collectively indicating significant cardiac functional recovery.
期刊介绍:
Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.