American journal of translational research最新文献

{"title":"Quantitative assessment of the association between TNF-α gene polymorphisms and angina risk.","authors":"Sen Xu, Jielei Zhou, Yunzhu Zhang","doi":"10.62347/YXRF7966","DOIUrl":"10.62347/YXRF7966","url":null,"abstract":"<p><strong>Background: </strong>Previous investigations into the correlation between tumor necrosis factor-α (TNF-α) gene polymorphism and susceptibility to angina have produced a range of results. This study aims to clarify the potential significance of TNF-α polymorphism as a contributing factor to the onset of angina.</p><p><strong>Methods: </strong>A comprehensive review of all corresponding literature was conducted across several major databases, covering their records from inception through to March 2024. Data were synthesized using meta-analysis techniques.</p><p><strong>Results: </strong>Notable associations were identified in various genetic comparisons: allele contrast (A vs. G: OR=0.77, 95% CI=0.70-0.86, P<0.001), homozygote comparison (AA vs. GG: OR=3.35, 95% CI=2.51-4.48, P<0.001), heterozygote comparison (GA vs. GG: OR=1.69, 95% CI=1.19-2.40, P=0.003), recessive genetic model (AA vs. GG/GA: OR=2.40, 95% CI=1.91-3.03, P<0.001), and dominant genetic model (AA/GA vs. GG: OR=1.84, 95% CI=1.27-2.65, P=0.001). Furthermore, ethnicity-based subgroup analyzes revealed that these associations were especially significant within the Asian population and unstable angina, with all genetic models demonstrating statistical significance (P<0.05).</p><p><strong>Conclusions: </strong>TNF-α gene is significantly associated with an increased risk of angina, particularly among the Asian population and unstable angina. This finding underscores the importance of considering genetic factors in the assessment and management of angina risk.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factor analysis and predictive model construction for postoperative bleeding in early esophageal cancer.","authors":"Lan Huang, Jiangtao Li, Yuanyuan Zheng, Renlong Lu, Lianying Yu","doi":"10.62347/KSVJ3486","DOIUrl":"10.62347/KSVJ3486","url":null,"abstract":"<p><strong>Objective: </strong>A multivariate logistic regression model was developed to identify the risk factors for postoperative bleeding in patients undergoing endoscopic submucosal dissection (ESD) for early esophageal cancer.</p><p><strong>Methods: </strong>The clinical data of 258 patients with early esophageal cancer who received ESD in Jiujiang Number One People's Hospital from April 2019 to March 2022 were retrospectively analyzed. Patients with or without postoperative bleeding were included into a bleeding group and a control group, respectively, and general information with statistically significant difference between the two groups was included in the multivariate logistic regression model to screen the risk factors for postoperative bleeding in the patients. The risk factors were then used to construct a nomogram prediction model for postoperative bleeding, and internal (training set) and external (validation set) validation was performed.</p><p><strong>Results: </strong>(1) The incidence of post-ESD bleeding was 12.02% in the 258 patients with early esophageal cancer. (2) History of hypertension, lesion diameter, submucosal fibrosis, C-reactive protein (CRP), and albumin (ALB) were independent risk factors for postoperative bleeding after ESD in the patients (<i>P</i><0.05). (3) The results of receiver operator characteristic curve (ROC) showed that the area under the curve (AUC) was 0.821 for the training set and 0.740 for the validation set. (4) The correction curve showed that the actual and predicted values of the training and validation sets were well fitted.</p><p><strong>Conclusion: </strong>Hypertension history, lesion diameter, submucosal fibrosis, CRP, and ALB are risk factors for postoperative bleeding in patients with early esophageal cancer undergoing ESD. The nomograms established based on these factors has good predictive value for postoperative bleeding in these patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness and safety of Camrelizumab immunotherapy in treating advanced esophageal carcinoma.","authors":"Yusheng Pan, Jinsong Ding","doi":"10.62347/KMCL5401","DOIUrl":"10.62347/KMCL5401","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical effectiveness and safety of Camrelizumab immunotherapy in patients with advanced esophageal carcinoma (aEC).</p><p><strong>Methods: </strong>A retrospective study was conducted on 142 aEC cases admitted between May 2020 to October 2022. The patients who received albumin-bound paclitaxel (ALB-bound PTX) and cis-platinum (DDP) were grouped into the control group (n=72), and the others received Camrelizumab immunotherapy in combination with ALB-bound PTX and DDP were grouped in to the research group (n=72). The clinical effectiveness, side effects (rash, nausea/vomiting, impaired liver function, leukopenia, thrombocytopenia, and alopecia), tumor marker levels (CEA, CA199, and CA125), immunoglobulin levels (IGA, IGM, and IGG), immune molecule levels (PD-1 and PD-L1), and the one-year survival rate were compared between the two groups. Furthermore, the risk factors affecting therapeutic effectiveness were identified by binary Logistic regression analysis.</p><p><strong>Results: </strong>Compared to the control group, the research group demonstrated a higher overall response rate, fewer side effects, and greater reductions in the levels of CEA, CA199, and CA125 after treatment. IgA, IgM, and IgG levels increased significantly in both groups after treatment, with a more pronounced improvement in the research group. PD-1 and PD-L1 levels decreased significantly after treatment, especially in the research group. The one-year survival rate was higher in the research group. Furthermore, treatment modality was a risk factor affecting therapeutic effectiveness in aEC patients.</p><p><strong>Conclusions: </strong>Camrelizumab immunotherapy is highly effective in treating aEC. It can increase the one-year survival rate, and elevate the levels of immunoglobulins and immune molecules while reducing the levels of tumor markers and incidence of side effects.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspected agomelatine-induced tongue temperature perception abnormality: a case report.","authors":"Li-Lei Lei, Min-Cai Qian, Shi-Liang Wang, Chen-Jie Ge","doi":"10.62347/RGHC1274","DOIUrl":"10.62347/RGHC1274","url":null,"abstract":"<p><p>Tongue temperature perception abnormality typically refers to an alteration in the tongue's ability to sense temperature, which may manifest as diminished or lost perception of heat or cold, or abnormal sensations in the absence of significant temperature changes. This case report describes a 60-year-old female who developed tongue temperature perception abnormality following the use of agomelatine. The patient had a history of good health, with no surgical or chronic disease history, and no family history of mental illness. She presented with symptoms of emotional depression, irritability, and insomnia, and was diagnosed with depression. Initially treated with sertraline and oxazepam, the treatment was changed to agomelatine due to poor sleep quality. One week after starting agomelatine, the patient reported tongue discomfort, which progressed to temperature perception abnormality, leading to burns and blisters. After discontinuing agomelatine and switching to duloxetine treatment, the symptoms rapidly improved. This case suggests a potential adverse drug reaction induced by agomelatine. The report emphasizes the importance of monitoring drug side effects and timely intervention in clinical practice.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of risk factors associated with postoperative hypoxemia in the postanesthesia care unit.","authors":"Ni Xiong, Yueqin Nong, Yaping Yi","doi":"10.62347/LCKG5157","DOIUrl":"10.62347/LCKG5157","url":null,"abstract":"<p><strong>Objective: </strong>To identify the risk factors associated with postoperative hypoxemia in the postanesthesia care unit (PACU), providing evidence-based recommendations for its prevention.</p><p><strong>Methods: </strong>Observational studies examining the risk factors for postoperative hypoxemia in PACU patients were systematically searched in PubMed, Embase, Cochrane Library, and Web of Science databases from their inception to June 2024. Two independent reviewers screened the literature, extracted data, and assessed the quality of the studies. Meta-analysis was performed using RevMan 5.3 software, employing fixed or random effects models to calculate odds ratios (OR), relative risks (RR), and 95% confidence intervals (CI).</p><p><strong>Results: </strong>A total of 11 studies were included, comprising 8 cohort studies, 2 case-control studies, and 1 cross-sectional study, with a total of 24,147 subjects, of whom 5,587 experienced hypoxemia. The meta-analysis identified the following significant risk factors for postoperative hypoxemia in the PACU: Advanced age (OR=1.19, 95% CI: 1.11-1.29, <i>P</i><0.001); Elevated body mass index (BMI) (OR=1.64, 95% CI: 1.36-1.97, <i>P</i><0.001); Low preoperative oxygen saturation (OR=3.16, 95% CI: 2.56-3.91, P<0.001); Smoking status (OR=1.67, 95% CI: 1.15-2.43, P<0.05); Surgery duration >120 minutes (OR=1.43, 95% CI: 1.22-1.69, P<0.001); Opioid analgesic use (OR=1.51, 95% CI: 1.31-1.74, P<0.001).</p><p><strong>Conclusion: </strong>These findings highlight the need for targeted preventive strategies in patients at high risk for postoperative hypoxemia in the PACU.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of IL-10 and GFPA for postoperative prognosis in patients with brain glioma.","authors":"Fuchao Yu, Xiang Fang, Jie Zhu, Bo Li, Bin Du","doi":"10.62347/BMCF6123","DOIUrl":"10.62347/BMCF6123","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prognostic value of interleukin (IL)-10 and glial fibrillary acidic protein (GFPA) in patients with brain glioma following surgery.</p><p><strong>Methods: </strong>The clinical data of 75 patients with brain glioma (Observation group) who were treated at the Central Hospital Affiliated with Shandong First Medical University were retrospectively analyzed. Additionally, 40 healthy volunteers who underwent physical examination during the same period were selected as the control group. The serum levels of IL-10 and GFPA were compared between the observation group and the control group as well as across different clinicopathological characteristics of the glioma patients. Multivariate logistic regression analysis was used to identify factors influencing postoperative brain injury in patients with brain gliomas. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of preoperative IL-10 and GFPA levels for patient prognosis.</p><p><strong>Results: </strong>Serum levels of IL-10 and GFPA in the observation group were significantly higher than those in the control group (all P<0.05). Before surgery, there was no significant differences in serum IL-10 and GFPA levels between the mild- and moderate-severity group; however, postoperatively, both markers were elevated in the moderate-severity group compared to the mild group (all P<0.05). Patients with World Health Organization (WHO) grade III-IV, mutant protein 53 (P53) genotype, and high Ki-67 expression exhibited higher IL-10 levels than their counter parts. However, the trends were conversely observed for GFAP. Pearson correlation analysis showed that IL-10 and GFPA levels were negatively associated with Glasgow Coma Scale (GCS) scores after surgery. Logistic regression analysis showed that IL-10 and GFPA were the independent risk factors for postoperative brain injury in glioma patients. The area under the curve (AUC) of IL-10 and GFPA for predicting the postoperative brain injury in glioma patients were 0.718 and 0.745, respectively; while their combined detection achieved an AUC of 0.835, which was significantly higher than each single detection.</p><p><strong>Conclusion: </strong>Elevated serum IL-10 and GFPA levels in patients with brain glioma are associated with postoperative brain injury. IL-10 and GFPA can serve as valuable indicators for the prognostic evaluation of patients with brain gliomas.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factor analysis and predictive model construction for bone metastasis in newly diagnosed malignant tumor patients.","authors":"Chengru Hu, Jing Wu, Zhipei Duan, Jing Qian, Jing Zhu","doi":"10.62347/MPEV9272","DOIUrl":"10.62347/MPEV9272","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors for bone metastasis in patients with newly diagnosed malignant tumor and to develop a prediction model.</p><p><strong>Methods: </strong>Clinical data from 232 patients with newly diagnosed malignant tumors were analyzed to screen for risk factors associated with bone metastasis. A nomogram prediction model was constructed using R software. The model's performance was evaluated using Receiver Operating Characteristic (<i>ROC</i>) analysis, Bootstrap sampling, and Decision Curve Analysis (<i>DCA</i>).</p><p><strong>Results: </strong>The incidence of bone metastasis in the 232 cases with newly diagnosed malignant tumors was 21.98% (51/232). Multivariate logistic regression analysis revealed that tumor staging III-IV, lymph node metastasis, high Eastern Cancer Collaboration Group Physical Status (ECOG-PS) score, high alkaline phosphatase (ALP) expression, and high SII index were risk factors for bone metastasis at initial diagnosis (all <i>P</i><0.05). The area under the curve (AUC) of the nomogram model was 0.893. Bootstrap sampling validation showed a small error of 0.017 between predicted and actual probabilities. DCA supported the utility of the model in clinical practice.</p><p><strong>Conclusion: </strong>Bone metastasis in newly diagnosed malignant tumors is associated with advanced tumor staging, lymph node metastasis, high ECOG-PS score, elevated ALP expression, and a high SII index. A nomogram model based on these factors can effectively predict the risk of bone metastasis in these patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the application of ultrasonographic parameters for fluid management in obstetric anesthesia.","authors":"Qingqing Yu, Shaobing Dai, Xiaoping Chen, Xufeng Zhang, Xinzhong Chen","doi":"10.62347/QMYL9341","DOIUrl":"10.62347/QMYL9341","url":null,"abstract":"<p><p>Ultrasound provides a valuable non-invasive approach for fluid management in obstetric anesthesia. Ultrasonographic parameters assist anesthesiologists to effectively assess the fluid status of parturients and reduce related complications. In addition to conventional parameters, which have been widely validated in clinical practice, we provide new insights into arterial parameters such as peak velocity, velocity-time integral, corrected flow time, and vein-related parameters, including the internal jugular vein and its collapsibility index, the inferior vena cava and its collapsibility index, as well as subclavian vein and its collapsibility index. These parameters can potentially enhance fluid management in obstetric anesthesia.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a prognostic nomogram based on the hub genes of patients with hypertensive intracerebral hemorrhage.","authors":"Ruoshui Sun, Jie Liu, Peigang Hui, Yaolei Zhang, Zhe Xiao","doi":"10.62347/CUWD4200","DOIUrl":"10.62347/CUWD4200","url":null,"abstract":"<p><strong>Objective: </strong>Hypertensive intracerebral hemorrhage (HICH) is frequently associated with high disability, high mortality, and poor prognosis. The present study aimed to identify genes associated with HICH to construct prognostic models to improve accuracy in predicting HICH prognosis.</p><p><strong>Methods: </strong>Hub genes were identified by screening out differentially expressed genes from data in the Gene Expression Omnibus database and conducting weighted gene co-expression network analysis. 68 patients with HICH were recruited and categorized based on prognosis. The univariate logistic, least absolute shrinkage and selection operator, and multivariate logistic regression models were then established based on clinical data and the identified hub genes. A prognostic model was constructed based on the nomogram score. The model was validated using receiver operating characteristic curve, C-index, calibration plots, and decision curve analysis. It was also compared to a prognostic model constructed based on clinical data alone. The prognostic value of the nomogram score was assessed in different subgroups.</p><p><strong>Results: </strong>Three hub genes: pro-platelet basic protein (PPBP), PDZ and LIM domain protein 1 (PDLIM1), and metalloproteinase 1 (TIMP1) were identified as significantly correlated to adverse outcomes in HICH. These hub genes, in combination with the clinical data, were used to construct a nomogram score system, which exhibited strong predictive power, excellent consistency between actual outcomes and predictions, and a higher net clinical benefit. HICH patients with high scores presented significantly worse outcome. Importantly, the developed nomogram score system was superior to the use of clinicopathological features in predicting HICH prognosis. The nomogram score system exhibited adequate predictive performance in different subgroups as well.</p><p><strong>Conclusion: </strong>The nomogram score system based on PPBP, PDLIM1, and TIMP1 genes, along with clinical data, exhibited superior performance in predicting adverse outcome in HICH patients. This system could, therefore, be useful for guiding clinical decisions and providing valuable insight for designing individualized treatments for HICH patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of humanized nursing interventions on psychological well-being and quality of life in rectal cancer patients undergoing chemotherapy.","authors":"Yan Zhang, Hui Wang, Wenjing Shan, Jia Cao, Yan Huang","doi":"10.62347/SJOW3057","DOIUrl":"10.62347/SJOW3057","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of humanized nursing interventions on rectal cancer patients undergoing chemotherapy.</p><p><strong>Methods: </strong>A retrospective study was conducted on 110 rectal cancer patients admitted to Xijing Hospital of the Fourth Military Medical University. Patients were randomized into an observation group (n=55) and a control group (n=55) according to the type of nursing interventions received. The observation group received humanized nursing care, which included modifications to the hospitalization environment, psychological support, dietary guidance, and appropriate exercise. The control group received standard nursing care, including health education and medication management. Both interventions were administered throughout the hospitalization period. Due to serious adverse reactions during chemotherapy, some patients withdrew from the study, resulting in 54 patients in the observation group and 53 patients in the control group. Psychological status, quality of life, and nutritional status were assessed before and after the intervention, and complications and patient satisfaction were statistically analyzed.</p><p><strong>Results: </strong>Following the intervention, both groups showed a significant reduction in Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores upon discharge, and an increase in all dimensions of the Generic Quality of Life Inventory-74 (GQOLI-74), with more pronounced changes in the observation group (all P < 0.05). Upon discharge, hemoglobin (Hb), serum total protein (TP), and albumin (Alb) levels had decreased in both groups compared to pre-intervention levels, but the observation group exhibited higher levels of these indicators than the control group (P < 0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (P > 0.05), but nursing satisfaction was higher in the observation group than the control group (P < 0.05).</p><p><strong>Conclusion: </strong>Humanized nursing interventions significantly improve nutritional status, alleviate psychological distress, and improve the quality of life for rectal cancer patients undergoing chemotherapy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}