American journal of translational research最新文献

{"title":"Endovascular therapy for iliac vein compression syndrome: superior outcomes in non-thrombotic patients and risk factors for stent restenosis.","authors":"Zhongyin Wu, Kewu He, Xiaozheng Peng, Wanli Lin","doi":"10.62347/PAOE4803","DOIUrl":"10.62347/PAOE4803","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the long-term efficacy and thrombotic outcomes of endovascular therapy for iliac vein compression syndrome (IVCS), with a focus on identifying risk factors for postoperative stent restenosis.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 98 IVCS patients treated with endovascular therapy at Hefei First People's Hospital between January 2020 and December 2022. Patients were divided into non-thrombotic (NIVCS, n=48) and acute thrombotic (TIVCS, n=50) groups. Outcomes included 1-year stent patency, complications, and quality-of-life metrics (CIVIQ-20 and VCSS scores). Logistic regression was used to identify risk factors for restenosis, with diagnostic performance accessed via ROC analysis.</p><p><strong>Results: </strong>The NIVCS group demonstrated significantly better 1-year stent patency (91.67% vs. 74%, P=0.018) but higher complication rates (20% vs. 8.33%, P=0.025) compared to the TIVCS group. Both groups showed significant improvements in CIVIQ-20 and VCSS scores (P<0.05), with NIVCS patients achieving better final outcomes. Multivariate analysis identified thrombotic IVCS (OR=3.41, 95% CI: 1.28-9.07), body mass index ≥28 kg/m² (OR=2.89, 95% CI: 1.15-7.26), and hypertension (OR=2.54, 95% CI: 1.03-6.25) as independent predictors of restenosis. The predictive model demonstrated strong discriminative capacity (AUC=0.82, 95% CI: 0.74-0.90).</p><p><strong>Conclusion: </strong>Endovascular therapy effectively improves symptoms and quality of life in IVCS, particularly in non-thrombotic cases. The thrombotic subtype, obesity, and hypertension significantly influence long-term stent patency, highlighting the need for personalized postoperative management. These findings underscore the potential of risk-stratified therapeutic strategies in vascular interventions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3521-3529"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective study of continuous low-dose norepinephrine infusion during induction of anesthesia: effects on the stability of blood pressure and recovery quality in elderly patients undergoing robotic radical prostatectomy.","authors":"Aini Maimaitiming, Bing Zhang, Jie Chen, Xiaohai Wang","doi":"10.62347/HWWN6029","DOIUrl":"10.62347/HWWN6029","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effect of low-dose norepinephrine infusion on hemodynamic changes during anesthesia induction and its correlation with postoperative recovery in elderly patients undergoing robot-assisted radical prostatectomy.</p><p><strong>Methods: </strong>A prospective observational study was conducted on 63 elderly patients divided into two groups: the norepinephrine group (NE group) receiving 2-5 μg/kg·h norepinephrine by injection pump during anesthesia induction, and the control group (C group) with regular anesthesia. Heart rate (HR) and invasive blood pressure (BP) were recorded at four time points: before induction, pre-intubation lowest value (T1), post-intubation (T2), and lowest BP between intubation and skin incision (T3). Postoperative recovery (QoR-15) was evaluated on Days 1 and 3.</p><p><strong>Results: </strong>Statistically significant differences in systolic (SBP) and diastolic blood pressure (DBP) were observed between groups at T1 and T3 (P<0.05), but no significant differences in HR were found at any time point (P>0.05). The NE group had significantly higher SBP, DBP, and HR at T1 and T3 compared to the C group (P<0.05). Hemodynamic stability was significantly better in the NE group (P<0.05). No significant differences were seen in QoR-15 scores or postoperative hospital stay between groups (P>0.05), but the Barthel Index increased significantly in the NE group (P<0.05).</p><p><strong>Conclusions: </strong>Continuous low-dose norepinephrine infusion effectively reduced blood pressure and heart rate fluctuations during anesthesia induction. However, the study showed only a weak correlation between intraoperative hemodynamic changes and postoperative recovery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"4054-4061"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of gut-brain axis dysregulation in the pathogenesis of non-alcoholic fatty liver disease: mechanisms and therapeutic implications.","authors":"Mei Wan, Weimin Zhao, Yifan Cai, Qian He, Jun Zeng","doi":"10.62347/ZWSR4476","DOIUrl":"10.62347/ZWSR4476","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health challenge due to its rising prevalence and strong association with metabolic syndrome. Recent studies highlight the critical role of the gut-brain axis (GBA)-a bidirectional communication system between the gut, brain, and liver-in NAFLD pathogenesis. Dysregulation of this axis can worsen metabolic dysfunction, inflammation, and liver injury. This review discusses the mechanisms driving GBA dysregulation in NAFLD, including alterations in gut microbiota, increased intestinal permeability, neuroinflammation, and imbalances in the autonomic nervous system (ANS). We also explore therapeutic strategies, such as microbiota modulation, vagus nerve stimulation, and neuroprotective interventions, that may help mitigate the effects of GBA dysfunction on NAFLD progression.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3276-3292"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved YOLOv8-seg for laryngeal structure recognition in medical images.","authors":"Haipo Cui, Jinjing Wu, Tianying Li, Zui Zou, Wenhui Guo, Long Liu, Qianwen Zhang, Xiaoping Huang","doi":"10.62347/BIHI3707","DOIUrl":"10.62347/BIHI3707","url":null,"abstract":"<p><strong>Objectives: </strong>Tracheal intubation is a routine procedure in clinical surgeries and emergency situations, essential for maintaining respiration and ensuring airway patency. Due to the complexity of laryngeal structures and the need for rapid airway management in critically ill patients, real-time, accurate identification of key laryngeal structures is crucial for successful intubation. This study presents a real-time laryngeal structure recognition method based on an improved YOLOv8-seg model.</p><p><strong>Methods: </strong>Laryngeal images from retrospective intubation procedures were used to assist clinicians in the rapid and precise identification of critical laryngeal structures, such as the epiglottis, glottis, and vocal cords. The proposed model, named SlimMSDA-YOLO, integrates a lightweight neck structure, Slimneck, into the original YOLOv8n-seg model by combining GSConv and standard convolutions. This modification effectively reduces the floating-point operations and computational resource requirements. Additionally, a multi-scale dilation attention module was incorporated between the neck and head sections to enhance the network's ability to capture features across various receptive fields, thereby improving its focus on critical regions.</p><p><strong>Results: </strong>The SlimMSDA-YOLO model achieved a precision of 90.4%, recall of 84.2%, and mAP50 of 90.1%. The model's Giga Floating Point Operations Per Second was 11.4, and the number of parameters was 3,139,819. These results demonstrate the effectiveness of the proposed method in enhancing both model efficiency and performance.</p><p><strong>Conclusions: </strong>The SlimMSDA-YOLO model is lightweight and efficient, making it ideal for real-time laryngeal structure recognition during intubation. Comparative experiments with other lightweight segmentation networks highlight the effectiveness and superiority of the proposed approach.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3293-3306"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Downregulation of miR-301a-3p sensitizes pancreatic cancer cells to gemcitabine treatment via PTEN.","authors":"Xiang Xia, Kundong Zhang, Guangtao Luo, Gang Cen, Jun Cao, Kejian Huang, Zhengjun Qiu","doi":"10.62347/VDDD1924","DOIUrl":"https://doi.org/10.62347/VDDD1924","url":null,"abstract":"<p><p>[This corrects the article on p. 1886 in vol. 9, PMID: 28469793.].</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"4067-4068"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of an early diagnostic model for brain injury in premature infants based on combined amplitude-integrated electroencephalography and cranial ultrasound parameters.","authors":"Yu Wang, Yun Chen, Sihang Tian","doi":"10.62347/WYPA8581","DOIUrl":"10.62347/WYPA8581","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate an early diagnostic model for brain injury in premature infants (BIPI) using combined amplitude-integrated electroencephalography (aEEG) and cranial ultrasound (CUS) parameters, aiming to enhance the accuracy of early BIPI detection.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included 350 premature infants admitted to the Neonatal Intensive Care Unit (NICU) of the First Affiliated Hospital of Xi'an Medical University between August 2018 and October 2023. Key aEEG parameters (upper boundary voltage, lower boundary voltage, narrow bandwidth, and aEEG score) and CUS parameters (systolic blood flow velocity, diastolic blood flow velocity, and resistance index) were collected. Feature selection was performed using Lasso regression, and a combined risk prediction model was developed. Model performance was assessed using receiver operating characteristic (ROC) curves and the area under the curve (AUC).</p><p><strong>Results: </strong>Significant differences were observed in both aEEG and CUS parameters between the brain injury group (n = 145) and the non-injury group (n = 205) (all P < 0.05). Lasso regression identified seven key parameters for model construction. The combined model achieved an AUC of 0.89, with a sensitivity of 86.21% and specificity of 79.51%, significantly outperforming models based on aEEG or CUS parameters alone (P < 0.001).</p><p><strong>Conclusion: </strong>The combined aEEG and CUS model significantly improves the early detection of BIPI and may facilitate timely interventions to reduce the risk of long-term neurodevelopmental impairments in premature infants.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3875-3888"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of metformin combined with insulin aspart on gestational weight gain, lipid metabolism, immune function, and delivery outcomes in pregnant women with gestational diabetes.","authors":"Junfen Cui, Yongmei Huang, Xiao Wang","doi":"10.62347/ROSD8026","DOIUrl":"10.62347/ROSD8026","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of metformin combined with insulin aspart on gestational weight gain, lipid metabolism, immune function, and delivery outcomes in women with gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>Clinical data from 95 GDM patients were retrospectively analyzed. Patients were divided into two groups: the control group (45 cases) received only insulin aspart, and the study group (50 cases) received a combination of metformin and insulin aspart. Clinical efficacy, blood glucose levels, body weight, lipid metabolism levels [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low - density lipoprotein cholesterol (LDL-C)], immune function, insulin resistance [fasting insulin (FINS), homeostasis model assessment of β-cell function (HOMA-β), homeostasis model assessment of insulin resistance (HOMA-IR)], inflammatory markers, delivery outcomes, and drug safety were compared between the two groups.</p><p><strong>Results: </strong>The study group had a significantly higher total effective rate (96.00%) compared to the control group (80.00%) (P < 0.05). Post-treatment, blood glucose levels decreased significantly in both groups, with lower levels observed in the study group (all P < 0.05). Both groups showed weight gain, but the increase was less in the study group (P < 0.05). Levels of TC, TG, LDL-C, FINS, HOMA-IR, and inflammatory markers decreased significantly in both groups, with greater reductions in the study group (all P < 0.05). HDL-C, immune function markers, and HOMA-β increased, with more significant increases in the study group (all P < 0.05). The incidence of adverse delivery outcomes was significantly lower in the study group (26.00% vs. 62.22%) (P < 0.05), with no significant difference in adverse reaction rates (10.00% vs. 8.89%) (P > 0.05).</p><p><strong>Conclusion: </strong>Metformin combined with insulin aspart demonstrates significant therapeutic benefits in treating GDM. It effectively regulates blood glucose and lipid metabolism, controls weight gain, enhances immune function, reduces insulin resistance, suppresses inflammation, and lowers the incidence of adverse delivery outcomes, with good drug safety.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3435-3444"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung ultrasound score as a tool to assess pulmonary ventilation and disease severity in patients with acute respiratory distress syndrome.","authors":"Zhiqi Gao, Kuan Lu, Zugeng Yang, Liji Xing, Hong Xie","doi":"10.62347/MPBV9850","DOIUrl":"10.62347/MPBV9850","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of lung ultrasound (LUS) in assessing pulmonary ventilation status in patients with acute respiratory distress syndrome (ARDS).</p><p><strong>Methods: </strong>A total of 35 ARDS patients aged 29-93 years, admitted to the Anesthesiology Intensive Care Unit and scheduled for chest computed tomography (CT), were retrospectively analyzed. Prior to the CT scan, arterial blood gas samples were collected, and LUS scores were obtained using a Sonostar portable ultrasound device. Based on the Berlin definition, patients were categorized into mild ARDS and moderate-to-severe ARDS groups. Lung density, lung volume, proportions of lung volume in different ventilation states, and LUS scores were compared between the groups. Spearman correlation analysis was used to evaluate the relationship between LUS scores and other parameters.</p><p><strong>Results: </strong>Lung density, LUS scores, and the proportion of collapsed lung volume were significantly higher in the moderate-to-severe ARDS group than those in the mild ARDS group (all P < 0.05). In patients with moderate-to-severe ARDS, LUS scores showed a moderate correlation with the oxygenation index, lung density, and the proportion of collapsed lung volume. In mild ARDS patients, no significant correlation was observed between LUS scores and these parameters.</p><p><strong>Conclusion: </strong>LUS is an effective, non-invasive tool for evaluating pulmonary ventilation status in ARDS patients and is particularly reliable in assessing ventilation status in those with moderate-to-severe ARDS.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3404-3412"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the combined use of linaclotide and probiotics on clinical treatment efficacy and quality of life in patients with constipation-predominant irritable bowel syndrome.","authors":"Yu Gao, Xiangping Gong, Juanjuan Qi, Ping Guo","doi":"10.62347/GNSB4367","DOIUrl":"10.62347/GNSB4367","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of combining linaclotide with Bifid Triple Viable Capsules on clinical outcomes and quality of life (QoL) in patients with constipation-predominant irritable bowel syndrome (IBS-C).</p><p><strong>Methods: </strong>A retrospective analysis was performed on data from 189 IBS-C patients treated between April 2021 and January 2024. The control group (91 patients) received linaclotide, while the combined group (98 patients) received linaclotide plus Bifid Triple Viable Capsules. Outcomes assessed included bowel movement frequency, stool consistency scores, constipation severity, anxiety (Self-Rating Anxiety Scale, SAS), depression (Self-Rating Depression Scale, SDS), QoL (Irritable Bowel Syndrome Quality of Life, IBS-QoL), and symptom severity (Irritable Bowel Syndrome Severity Scoring System, IBS-SSS). Logistic regression identified independent risk factors for QoL improvement.</p><p><strong>Results: </strong>Both groups showed significant increases in bowel movement frequency after treatment (P < 0.001). The combined group experienced a significantly greater improvement compared to the control group (P < 0.001). Stool consistency scores improved significantly in both groups (P < 0.001), but no significant difference was observed between groups (P > 0.05). Both groups showed significant reductions in constipation severity, with the combined group showing greater improvement (P < 0.001). SAS and SDS scores decreased significantly in both groups (P < 0.001). The combined group showed greater reductions in SAS (P < 0.05) and SDS (P < 0.001). IBS-QoL scores improved significantly in both groups, with the combined group achieving greater improvement (P < 0.001). IBS-SSS scores decreased significantly, with the combined group experiencing a greater reduction (P < 0.001). IBS-QoL scores were positively correlated with bowel movement frequency (r = 0.289, P < 0.001) and negatively correlated with stool consistency scores (r = -0.154, P = 0.036), constipation severity (r = -0.386, P < 0.001), SDS scores (r = -0.150, P = 0.040), and IBS-SSS scores (r = -0.347, P < 0.001). Logistic regression identified treatment regimen (OR = 0.163, P = 0.017), age (OR = 4.666, P = 0.002), monthly income (OR = 0.065, P < 0.001), post-treatment bowel movement frequency (OR = 0.055, P < 0.001), and post-treatment constipation severity (OR = 5.545, P = 0.007) as independent factors influencing QoL improvement.</p><p><strong>Conclusion: </strong>The combined use of linaclotide and Bifid Triple Viable Capsules significantly enhances bowel movement frequency, reduces constipation severity, and improves QoL and psychological well-being in IBS-C patients. This approach offers a promising strategy for the comprehensive management of IBS-C.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3333-3344"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Puncture frequency, coagulopathy, and liver injury as independent risk factors for bleeding in acute diquat poisoning after enhanced blood purification therapy.","authors":"Ting Zhang, Ling Liu, Weibin Wang, Yanan Ma, Jianling Shi, Hua Gu","doi":"10.62347/NYSI3538","DOIUrl":"10.62347/NYSI3538","url":null,"abstract":"<p><strong>Objective: </strong>To identify independent risk factors for bleeding and propose preventive strategies in acute diquat poisoning (ADP) patients undergoing enhanced blood purification therapy (EBPT).</p><p><strong>Methods: </strong>In this retrospective study, a total of 297 ADP patients (May 2022-April 2024) were categorized into a conventional treatment (n=124) and EBPT (n=173) groups according to their treatment regimens. Clinical data, coagulation/liver function, and bleeding events were compared between the two groups. Logistics regression analysis was applied to identify independent risk factors for bleeding. COX regression model was used to explore the risk factors affecting survival prognosis. Kaplan-Meier method was used to draw survival analysis curve.</p><p><strong>Results: </strong>The EBPT group had a significantly higher bleeding incidence (45.05% vs. 4.23%, P<0.05), predominantly at puncture sites. Independent bleeding risk factors included puncture frequency, degree of poisoning, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), white blood cell count (WBC), elevated alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (P<0.05). Bleeding patients had a higher 28-day mortality rate (50.00% vs. 18.95%, P<0.05) and longer ICU stays. Cox analysis confirmed that ALT, puncture frequency, poisoning severity, and bleeding were significant survival predictors (P<0.05).</p><p><strong>Conclusion: </strong>EBPT increases bleeding risk in ADP patients, mainly due to procedural factors and organ dysfunction. Optimizing puncture techniques and closely monitoring coagulation and liver function may improve patient outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3961-3970"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}