American journal of translational research最新文献

{"title":"Clinical efficacy and predictive indicators of cindilizumab combined with XELIRI protocol in advanced colorectal carcinoma patients.","authors":"Weigeng Liu, Huhu Xue, Qian Lei, Ziyuan Jia, Shuang He, Guorui Ma","doi":"10.62347/KZDR9031","DOIUrl":"10.62347/KZDR9031","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the therapeutic efficacy of adding cindilizumab to the Xeloda-Irinotecan (XELIRI) regimen in patients with advanced colorectal cancer and to identify clinical and molecular biomarkers predictive of treatment response.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 197 patients with advanced colorectal carcinoma treated between January 2019 and June 2023. Patients were divided into two cohorts: the standard treatment group receiving XELIRI alone (n=103) and the combined treatment group receiving XELIRI with cindilizumab (n=94). Treatment response was assessed according to RECIST criteria and classified as responsive (complete response [CR] or partial response [PR]) or non-responsive (stable disease [SD] or progressive disease [PD]). Logistic regression analysis was performed to identify independent predictors of treatment response. Adverse events were recorded throughout the treatment course.</p><p><strong>Results: </strong>The experimental cohort demonstrated statistically higher objective response rate (ORR) and disease control rate (DCR) compared to the standard treatment cohort (ORR: 38.30% versus 22.33%, P=0.015; DCR: 80.85% versus 66.02%, P=0.019). The incidence of hypothyroidism and renal impairment was significantly higher in the combination group (P=0.002). Logistic regression identified carcinoembryonic antigen (CEA) (OR=1.336, P<0.001), tumor diameter (OR=2.818, P=0.001), KRAS/NRAS gene status (OR=6.229, P=0.001), and treatment regimen (OR=0.079, P<0.001) as independent predictors of treatment response. Receiver operating characteristic (ROC) curve analysis showed that their combined prediction significantly improved predictive efficacy (AUC=0.881), with high sensitivity and specificity.</p><p><strong>Conclusion: </strong>Cindilizumab combined with XELIRI regimen improves ORR and DCR in patients with advanced colorectal cancer but may increase the risk of hypothyroidism and renal impairment. CEA, tumor diameter, KRAS/NRAS gene, and treatment regimen are independent predictors of treatment response. The combined predictive model demonstrates robust diagnostic performance.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6180-6190"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holdaway analysis exhibits the highest correlation with facial profile attractiveness among nine cephalometric analyses.","authors":"Hongyu Ren, Xin Chen, Yongqing Zhang","doi":"10.62347/JSWV8973","DOIUrl":"10.62347/JSWV8973","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between nine commonly used cephalometric analyses and facial profile attractiveness and to explore an optimized combination of cephalometric measures.</p><p><strong>Methods: </strong>Sixteen nonprofessional evaluators assessed the profile attractiveness of 210 untreated Chinese adults using a visual analog scale. Eighty-seven cephalometric measures were obtained from nine analyses (Burstone, Downs, Holdaway, Jarabak, McNamara, Ricketts, Steiner, Tweed, and Wylie). Quadratic regression analysis was employed to identify measures significantly correlated with facial profile attractiveness and to calculate their maximum attractiveness values (MAVs). Stepwise regression was applied to assess the explanatory power of each analysis for profile attractiveness and to construct optimized predictive models.</p><p><strong>Results: </strong>The explanatory power of the nine analyses for attractiveness variation was ranked as follows: Holdaway (41.5%) > Ricketts (37.6%) > Steiner (36.8%) > Burstone (35.7%) > Tweed (35.6%) > Downs (33.9%) > McNamara (24.3%) > Wylie (13.2%) > Jarabak (6.1%). Among individual measures, the H-angle, ANB (°), A-Npog (mm), and NA-APo (°) accounted for more than 26% of attractiveness variation. A five-indicator model comprising H-angle (28.8%; MAV = 17.2°), L1-APog (14.6%; MAV = 0.5 mm), Wits appraisal (4.5%; MAV = 0.1 mm), ANS-Me/N-Me (4.2%; MAV = 54%), and ANS-Ptm (3.3%; MAV = 46.7 mm) explained 55.4% of the variation.</p><p><strong>Conclusion: </strong>Among the nine cephalometric analyses, the Holdaway method exhibited the strongest explanatory power for variation in profile attractiveness. The newly constructed five-indicator model may provide more precise aesthetic references for orthodontic and orthognathic treatments.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6236-6249"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial drug-derived carbon quantum dots for photodynamic therapy of bedsores and bacterial infections.","authors":"Qianwen Bi, Fumin Zheng, Ziqin Lu, Jia Sun","doi":"10.62347/YELM3779","DOIUrl":"10.62347/YELM3779","url":null,"abstract":"<p><strong>Objectives: </strong>Bedsores (pressure ulcers) exhibit high incidence rates (0.4-38%) and prolonged recovery periods, with bacterial infections posing the most frequent and severe complications, significantly impeding wound healing. Conventional antibiotic therapies face limitations due to antimicrobial resistance, necessitating innovative strategies with enhanced biocompatibility and reduced resistance-inducing potential. This study aimed to develop a photodynamic therapy (PDT)-based antimicrobial approach by converting antimicrobial drugs into N-doped carbon quantum dots (N, CQ-dots) for efficient bacterial inhibition in wound environments.</p><p><strong>Methods: </strong>N, CQ-dots were synthesized from protocatechuic acid (a natural antimicrobial metabolite) via solvothermal method, preserving critical functional groups (-COOH, -OH) inherited from the precursor. Structural and optical properties were characterized using transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and ultraviolet-to-visible (UV-Vis) spectroscopy. Photodynamic antimicrobial efficacy was evaluated against Staphylococcus aureus and Escherichia coli through colony-count assays, and live/dead staining.</p><p><strong>Results: </strong>The synthesized N, CQ-dots exhibited uniform morphology (~3.5 nm) and abundant oxygen-containing functional groups, as confirmed by XPS and Fourier Transform Infrared (FTIR) spectrometer analysis. Under irradiation, the material demonstrated potent antibacterial activity, achieving >99.9% viability reduction in Gram-positive and Gram-negative strains, with minimal cytotoxicity (MBC >100 μg/mL).</p><p><strong>Conclusions: </strong>This work demonstrates a novel paradigm for transforming antimicrobial drugs into multifunctional N, CQ-dots, leveraging preserved pharmacophores and PDT mechanisms to overcome drug resistance. The system combines intrinsic antibacterial activity with light-triggered responsiveness, offering a promising solution for managing infected bedsores while minimizing systemic toxicity. These findings highlight the translational potential of drug-derived nanomaterials in precision wound care.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6347-6358"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior visual quality outcomes with compound tropicamide eye drops in treating juvenile pseudomyopia.","authors":"Chao Bi, Fang-Ju Han, Gang Ding, Ye-Qiang Shi","doi":"10.62347/KRVZ8121","DOIUrl":"10.62347/KRVZ8121","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of Compound Tropicamide (Trop) Eye Drops on the visual quality in juvenile pseudomyopia patients.</p><p><strong>Methods: </strong>Data from 111 juvenile pseudomyopia patients treated between September 2019 and September 2022 were reviewed in this retrospective study, including 50 cases treated with Atropine Sulfate Ophthalmic Gel (control group) and 61 with Compound Trop Eye Drops (research group). Clinical efficacy, amplitude of accommodation (AA), uncorrected visual acuity (UCVA), intraocular pressure (IOP), axial length (AL), symptom improvement, complications, and quality of life were compared. Risk factors for visual quality improvement were analyzed using Logistic regression.</p><p><strong>Results: </strong>The research group demonstrated significantly higher treatment efficacy compared to the control group (P>0.05). Post-treatment, AA, IOP, and AL decreased notably in the research group compared to baseline and the control group (all P<0.05). UCVA and quality of life scores improved significantly in the research group (both P<0.05). Recovery indicators, including resolution of dizziness, alleviation of ocular soreness, and vision recovery, were significantly shorter in the research group (all P<0.05). Both groups had similar complication rates, including dry mouth, facial blushing, conjunctival congestion, and transient tachycardia (P>0.05). The research group reported superior post-treatment quality of life across all domains (all P<0.05). Logistic regression showed that gender, age, disease duration, family history of myopia, education level, AA, UCVA, and treatment method were not significant risk factors for visual quality improvement (all P>0.05).</p><p><strong>Conclusion: </strong>Compound Trop Eye Drops effectively enhances visual function and quality of life in juvenile pseudomyopia patients, with a safety profile comparable to low-dose atropine, offering potential clinical value.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6434-6441"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of cerebrospinal fluid heparin-binding protein and CD64 expression for postoperative central nervous system infection following intracerebral hemorrhage surgery.","authors":"Xujin Zhu, Weizhen Zhu, Xiaofeng Cheng, Haojie Wu","doi":"10.62347/VTBE6419","DOIUrl":"10.62347/VTBE6419","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the association and predictive value of cerebrospinal fluid (CSF) heparin-binding protein (HBP) and cluster of differentiation 64 (CD64) levels with postoperative central nervous system (CNS) infection following hypertensive intracerebral hemorrhage surgery.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 64 patients who developed postoperative CNS infections (infection group) and 70 patients without infections (non-infection group) after surgical treatment for hypertensive intracerebral hemorrhage at Shangyu People's Hospital of Shaoxing between February 2021 and February 2024. CSF HBP and CD64 levels were measured within 24-48 hours postoperatively. Univariate and multivariate logistic regression analyses were performed to identify risk factors for CNS infection. Receiver operating characteristic curve analysis was used to assess the predictive performance of the biomarkers.</p><p><strong>Results: </strong>Patients in the infection group were significantly older than those in the non-infection group. CSF HBP and CD64 levels were significantly elevated in the infection group (all P<0.05). Additionally, peripheral blood levels of procalcitonin, lactate dehydrogenase, and C-reactive protein were higher, whereas albumin levels were lower in the infection group (all P<0.05). Multivariate analysis identified elevated CSF HBP and CD64 as independent risk factors for CNS infection. The area under the curve values for predicting CNS infections were 0.745 for CSF HBP alone, 0.709 for CSF CD64 alone, and 0.846 when both markers were combined.</p><p><strong>Conclusions: </strong>Elevated CSF HBP and CD64 levels are closely associated with postoperative CNS infection following hypertensive intracerebral hemorrhage surgery. While each marker alone offers moderate predictive value, their combined use significantly enhances diagnostic accuracy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6225-6235"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical advantages of multifocal soft contact lenses in myopia control for adolescents.","authors":"Yongmei Cao, Jiabao Liu","doi":"10.62347/ZURH1418","DOIUrl":"10.62347/ZURH1418","url":null,"abstract":"<p><strong>Objective: </strong>To compare the clinical effectiveness of multifocal soft contact lenses (MFSCLs) and orthokeratology (OK) lenses in managing myopia in adolescents.</p><p><strong>Methods: </strong>This retrospective study enrolled 106 myopic adolescents, divided into two groups: OK (n=50) and MFSCLs (n=56). Refractive error (RE), intraocular pressure (IOP), axial length (AL), and choroidal thickness were measured at baseline (T0), 6-month follow-up (T1), and 12-month follow-up (T2). Additionally, accommodative amplitude, accommodative sensitivity, negative/positive relative accommodation (NRA/PRA), interleukin-6 (IL-6), epidermal growth factor (EGF), psychological status, and quality of life were compared between T0 and T2. Safety during treatment was also assessed.</p><p><strong>Results: </strong>Both interventions resulted in a significant increase in RE at T1 and T2 (P<0.05), with no significant differences between groups (P>0.05). IOP, AL, and choroidal thickness remained stable (all P>0.05). At T2, the MFSCLs group showed significant improvements in accommodative amplitude, accommodative sensitivity, and NRA (all P<0.05), along with a reduction in PRA (P<0.05), although no significant inter-group differences were observed (P>0.05). Furthermore, the MFSCLs group exhibited significantly lower IL-6 levels, higher EGF, and fewer adverse reactions (all P<0.05). Psychological status and quality of life improvements were significantly greater in the MFSCLs group (P<0.05).</p><p><strong>Conclusion: </strong>MFSCLs and OK lenses demonstrate comparable myopia control effects. However, MFSCLs offer additional benefits in reducing inflammation, enhancing safety, and improving mental health and quality of life.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6009-6018"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Leuprorelin combined with Mirena on endocrine function, emotion, quality of life, and endometrial receptivity in patients with adenomyosis.","authors":"Kexing Zhou, Wu Cao","doi":"10.62347/QPXN8103","DOIUrl":"10.62347/QPXN8103","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the combined effects of Leuprorelin and Mirena on endocrine profiles, emotional well-being, quality of life, and endometrial receptivity (ER) in patients with adenomyosis.</p><p><strong>Methods: </strong>This is a retrospective cohort study involving 144 patients with adenomyosis, in which 81 received Mirena alone and 63 received the combination of Mirena and Leuprorelin. Primary outcomes included menstrual volume, dysmenorrhea, uterine volume, hormone levels, emotional status, quality of life, and ER, assessed via clinical scales and ultrasound.</p><p><strong>Results: </strong>Combination therapy significantly reduced menstrual volume, dysmenorrhea, and uterine volume compared to Mirena alone (all P < 0.05). Endocrine hormone levels were notably lower in the combination group (P < 0.05). Anxiety improved significantly (P = 0.012), with trends toward improved depression outcomes. Psychological health and social quality of life also showed significant improvement (P < 0.05). ER was enhanced, with better endometrial characteristics and blood flow (P < 0.05). Adverse events were similar between groups.</p><p><strong>Conclusion: </strong>The combination of Leuprorelin and Mirena offers superior efficacy over Mirena alone in managing adenomyosis. This regimen provides enhanced symptom relief, reduces endocrine disruptions, and improves emotional well-being and quality of life without increasing adverse events.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6639-6651"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarkers for diagnosis and severity evaluation in knee osteoarthritis.","authors":"Fang Li, Jia-Yi Yao, Jing-Jing Cao, Jian-Hua Yao","doi":"10.62347/EAMP8048","DOIUrl":"10.62347/EAMP8048","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the serum levels of signal transducer and activator of transcription 3 (STAT3), vascular endothelial growth factor (VEGF), and interleukins (IL)-2 and IL-4 in patients with knee osteoarthritis (KOA), and to evaluate their diagnostic value for disease severity.</p><p><strong>Methods: </strong>A total of 115 KOA patients and 50 healthy controls were enrolled. Serum levels of STAT3, VEGF, IL-2, and IL-4 were measured in all participants. The correlations between these biomarkers and KOA severity were further analyzed.</p><p><strong>Results: </strong>Compared to healthy controls, KOA patients exhibited significantly elevated serum levels of STAT3, VEGF, IL-2, and IL-4 (all P < 0.05). Following standard treatment, the concentrations of these biomarkers significantly decreased. Receiver operating characteristic (ROC) curve analysis revealed that the area under the curve (AUC) values for diagnosing KOA were 0.710 for STAT3, 0.726 for VEGF, 0.704 for IL-2, and 0.797 for IL-4. Furthermore, the serum concentrations of these factors showed strong positive correlations with KOA severity (r = 0.436 for STAT3, r = 0.467 for VEGF, r = 0.497 for IL-2, and r = 0.509 for IL-4). Their AUC values for assessing disease severity were 0.723 (STAT3), 0.742 (VEGF), 0.769 (IL-2), and 0.757 (IL-4). Combined detection of these biomarkers improved diagnostic accuracy.</p><p><strong>Conclusions: </strong>Abnormally elevated serum levels of STAT3, VEGF, IL-2, and IL-4 in KOA patients are closely associated with disease severity and treatment efficacy. These biomarkers may serve as auxiliary indicators for KOA diagnosis and severity assessment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"5999-6008"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TPF regimen improves conversion surgery and short-term survival in patients with locally unresectable advanced gastric cancer.","authors":"Tingwang Duan, Dan Ma, Zhaoqin Bai, Xiaolong Ding, Xinhua Zhang","doi":"10.62347/FFQN8329","DOIUrl":"10.62347/FFQN8329","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy and safety of TPF versus FOLFOX regimens in conversion therapy for locally unresectable advanced gastric cancer (LAUGC) and to identify prognostic factors influencing clinical outcomes.</p><p><strong>Methods: </strong>This retrospective study analyzed 264 LAUGC patients treated with either TPF (n=140) or FOLFOX (n=124) between 2019 and 2021. Primary endpoints were objective response rate (ORR) and 1-year survival; secondary endpoints included conversion surgery rate, toxicity, and 3-year survival. Prognostic factors were evaluated using multivariate Cox regression and time-dependent ROC analyses.</p><p><strong>Results: </strong>The TPF group demonstrated significantly higher ORR (P=0.01) and disease control rate (DCR; P<0.001) compared to the FOLFOX group. Rates of conversion surgery (P=0.011) and R0 resection (P=0.003) were also improved. One-year survival was superior in the TPF cohort (P<0.05), whereas 3-year survival rates showed no significant difference (P>0.05). Although myelosuppression was more frequent with TPF (P=0.002), the incidence of severe adverse events was comparable between groups. Multivariate analysis identified FOLFOX regimen, elevated carcinoembryonic antigen (CEA), and N3 stage as risk factors for 1-year mortality, while higher albumin levels and lymphocyte counts were protective. Tumor size ≥5 cm and poor differentiation were associated with increased 3-year mortality risk. Albumin demonstrated strong predictive value for 1-year survival.</p><p><strong>Conclusion: </strong>The TPF regimen can effectively improve the objective response rate and short-term survival in LAUGC patients undergoing conversion therapy, with manageable myelosuppression. The analysis of prognostic risk factors facilitates individualized treatment strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6068-6079"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic outcomes of combined Bupivacaine Liposome, 1,4-Butanediol Diglycidyl Ether-crosslinked sodium hyaluronate, and arthroscopic debridement in knee osteoarthritis management.","authors":"Zhecheng Jiang, Xianfeng Wang, Litao Yan, Hao Nan, Lingze Chen, Chencheng Gu, Huan Li, Yun Li","doi":"10.62347/ICOU1354","DOIUrl":"10.62347/ICOU1354","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of arthroscopic debridement (AD) combined with Bupivacaine Liposome and 1,4-Butanediol Diglycidyl Ether (BDDE)-Crosslinked Sodium Hyaluronate in treating knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>A total of 195 KOA patients were recruited and assigned to two groups based on the treatment modality: a control group (n=95) receiving standard AD and a research group (n=100) receiving the combined therapy. The efficacy of the treatment, inflammatory biomarkers (including tumor necrosis factor-alpha [TNF-α], interleukin [IL]-1β, and IL-6), quality of life (QOL), and patient-reported satisfaction were assessed. Besides, multiple scales were employed, including the Visual Analog Scale (VAS) for pain intensity, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for symptom severity, as well as the Hospital for Special Surgery (HSS) Knee Score and Lysholm Knee Score for functional recovery.</p><p><strong>Results: </strong>The research group demonstrated significantly superior overall efficacy and treatment satisfaction compared to the control group (P<0.05). Post-intervention improvements were observed in knee function scores (HSS and Lysholm) and QOL in both cohorts, with the research group showing greater enhancements (P<0.05). Furthermore, the combination therapy led to more pronounced reductions in WOMAC subscale scores (dysfunction, pain, and stiffness), VAS scores, and inflammatory markers (TNF-α, IL-1β, and IL-6) compared to the control group (P<0.05).</p><p><strong>Conclusions: </strong>The combination of Bupivacaine Liposome, BDDE-Crosslinked Sodium Hyaluronate, and AD shows great therapeutic potential in the management of KOA, supporting its broad clinical generalization.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6019-6027"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}