American journal of translational research最新文献

{"title":"Effectiveness of orthokeratology plus vision therapy for controlling myopia progression in children.","authors":"Xiaoge Yang, Wei Zheng, Haixia Tian, Suling Yang, Yanxia Song","doi":"10.62347/CJEN3948","DOIUrl":"10.62347/CJEN3948","url":null,"abstract":"<p><strong>Objective: </strong>Addressing myopia in children, this study analyzed the effectiveness of orthokeratology (Ortho-K) plus vision therapy (VT) for controlling myopia progression.</p><p><strong>Methods: </strong>The study population was composed of 155 myopia-affected children (August 2022-August 2025), who were assigned to the ortho-K group (n=75) wearing Ortho-K lenses and the Ortho-K+VT group (n=80) that was additionally given VT intervention. Inter-group comparative assessments were then conducted from the perspectives of clinical effectiveness, visual acuity (VA) measures (best-corrected VA, uncorrected VA), refractive structural parameters (axial length, spherical equivalent), corneal parameters (central corneal thickness, mean keratometry), accommodation parameters (accommodation amplitude, accommodative facility, accommodative response), accommodation-convergence synergy parameters (positive/negative relative accommodation, accommodative convergence/accommodation ratio), complications (corneal epithelial punctate staining, conjunctival congestion, dry eye symptoms, papillary conjunctivitis), and vision-related quality of life (25-Item National Eye Institute Visual Function Questionnaire).</p><p><strong>Results: </strong>The total effective rate was significantly higher in the Ortho-K+VT group than in the Ortho-K group. After the intervention, all VA measures, refractive structure parameters, corneal parameters, accommodation parameters, accommodation-convergence synergy parameters, and vision-related quality of life were significantly better in patients receiving Ortho-K+VT. The total complication rate was significantly lower in the Ortho-K+VT group than in the Ortho-K group.</p><p><strong>Conclusion: </strong>Ortho-K combined with VT was effective in controlling myopia progression in children.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6928-6937"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of early essential newborn care after elective caesarean section on maternal and neonatal outcomes: a retrospective study.","authors":"Xiaojin Zhang, Li Ding, Mei He, Yingying Zhu, Jian Guo","doi":"10.62347/ZTJS7233","DOIUrl":"10.62347/ZTJS7233","url":null,"abstract":"<p><strong>Objective: </strong>Early essential newborn care (EENC) is a World Health Organization (WHO)-recommended package of evidence-based perinatal interventions, but evidence regarding its effects after elective caesarean section (CS) remains limited. We evaluated the effects of EENC on maternal and neonatal outcomes following elective CS.</p><p><strong>Methods: </strong>In this retrospective observational study, 590 patients who underwent CS from November 2021 to October 2022 were screened; after applying eligibility criteria, 282 were included for analysis: 125 in the EENC group (E group) and 157 in the routine care group (R group). Outcomes included intraoperative and 24-h postpartum blood loss, postoperative pain (visual analogue scale [VAS] at 2/24/48/72 h), exclusive breastfeeding rate, neonatal hospitalization, neonatal intensive care unit (NICU) admission and transcutaneous bilirubin (TcB). Continuous data were compared with the independent t-test or Mann-Whitney U test and categorical data with the chi-square or Fisher's exact test.</p><p><strong>Results: </strong>Intraoperative blood loss (239.20±74.21 vs. 259.87±85.37 mL, t=2.14, P=0.033) and 24-h postpartum blood loss (47.01±20.71 vs. 54.71±26.64 mL, t=2.66, P=0.008) were lower in the E group. The 2-h VAS score was lower in the E group (1.88 [1, 3] vs. 2.48 [1, 4], Z=3.32, P<0.001). The exclusive breastfeeding rate was higher (78.4% vs. 63.7%, χ²=7.20, P=0.005) and neonatal hospitalization shorter (4.04 [3, 5] vs. 4.20 [3, 6] days, P=0.021) in the E group. NICU admission, TcB and VAS at 24-72 h did not differ.</p><p><strong>Conclusion: </strong>EENC after elective CS was associated with reduced intraoperative and 24-h postpartum blood loss, lower early postoperative pain, higher exclusive breastfeeding rates and shorter neonatal hospitalization, supporting broader implementation of EENC in CS deliveries.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7331-7341"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The adjunctive use of Bifidobacterium Quadruple Viable Bacteria with interferon in pediatric acute enteritis: inhibition of gut hormones, pain mediators, and systemic inflammation.","authors":"Renjing Lin, Haiyan Lu","doi":"10.62347/EDUD5324","DOIUrl":"10.62347/EDUD5324","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the adjunctive efficacy of Bifidobacterium Quadruple Viable Bacteria combined with recombinant human interferon α1b in pediatric acute enteritis (PAE).</p><p><strong>Methods: </strong>This retrospective propensity score matching (PSM) analysis included children aged 1-6 years with PAE admitted from March 2024 to March 2025. Patients receiving conventional therapy alone were assigned to the control group, while those receiving Bifidobacterium Quadruple Viable Bacteria plus recombinant human interferon α1b on the basis of conventional therapy were assigned to the observation group. A total of 128 children were included, with 64 cases in each group. Serum gut hormones, intestinal barrier markers, pain mediators, inflammatory factors, and oxidative stress indicators were compared before and after treatment.</p><p><strong>Results: </strong>After treatment, the observation group showed greater reductions in motilin and gastrin and a more marked increase in somatostatin than the control group. Substance P (SP) and prostaglandin E2 (PGE2) were also lower in the observation group, indicating reduced pain mediator release. In addition, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) declined more prominently, while superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased and malondialdehyde (MDA) decreased more substantially, suggesting alleviation of systemic inflammation and oxidative stress.</p><p><strong>Conclusion: </strong>In this retrospective PSM analysis, Bifidobacterium Quadruple Viable Bacteria combined with interferon α1b improved gut hormone balance, intestinal barrier function, pain-related mediators, inflammatory responses, and oxidative stress in PAE.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6651-6661"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of goserelin combined with laparoscopic surgery for endometriosis and its effects on ovarian function and oxidative stress.","authors":"Wanying Ma, Tao Li, Yang Ou, Zijun Zhou, Yuyan Deng","doi":"10.62347/DNDW4937","DOIUrl":"10.62347/DNDW4937","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy of goserelin (GOS) combined with laparoscopic surgery (LS) in the treatment of endometriosis (EMS), and its effects on ovarian function and oxidative stress (OS).</p><p><strong>Methods: </strong>A total of 208 patients with EMS were enrolled in this retrospective study. The control group (n=102) received LS alone, while the research group (n=106) received GOS combined with LS. The endpoints included therapeutic efficacy, time to ovulation resumption, time to menstrual recovery, dysmenorrhea, pelvic pain, ovarian function indices [follicle-stimulating hormone (FSH), estradiol (E₂), luteinizing hormone (LH)], inflammatory markers [interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α], OS indices [reactive oxygen species (ROS), malondialdehyde (MDA), advanced oxidation protein products (AOPP)], adverse reactions, and postoperative recurrence. Subgroup analyses were performed by stratifying patients based on age, ovarian cyst diameter, and American Society for Reproductive Medicine (ASRM) classification.</p><p><strong>Results: </strong>Compared to the control group, the research group showed the following significant differences: (1) The total effective rate was notably higher, and the time to ovulation resumption and menstrual recovery was significantly shorter; (2) Postoperative dysmenorrhea and pelvic pain were evidently relieved, and the postoperative levels of FSH, E₂, LH, IL-1β, IL-6, TNF-α, ROS, MDA, and AOPP were statistically lower; (3) The recurrence rates at 6 months and 1 year after surgery were significantly reduced (all P<0.05). There was no significant difference in the overall incidence of adverse reactions between groups (P>0.05). The interactions of age, ovarian cyst diameter, and ASRM classification with therapeutic efficacy were not statistically significant (all P>0.05).</p><p><strong>Conclusion: </strong>On the basis of LS, the addition of GOS is effective for the treatment of EMS, and it exerts positive effects on improving ovarian function and inhibiting OS.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6938-6947"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yishen Quyu Lishi Formula suppresses multiple myeloma growth via ERK/mTOR-mediated inhibition of protective autophagy and induction of apoptosis.","authors":"Juan Song, Hongyong Yang, Yifei Wang, Yuning Zhang, Xiujun Li","doi":"10.62347/EGUV4191","DOIUrl":"10.62347/EGUV4191","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the anti-tumor effect of Yishen Quyu Lishi Formula (YSQYLSF) on multiple myeloma (MM) and to determine whether this effect is mediated by extracellular signal-regulated kinase/mammalian target of rapamycin (ERK/mTOR)-regulated protective autophagy and apoptosis.</p><p><strong>Methods: </strong>H929 xenograft-bearing nude mice were treated with YSQYLSF, bortezomib (BO), or their combination for 21 days. Tumor growth, body weight, histopathology, immunohistochemistry, reverse transcription quantitative polymerase chain reaction (RT-qPCR), Western blotting, and ribonucleic acid sequencing (RNA-Seq) were performed. H929 cells were further used for cell viability assays, green fluorescent protein-microtubule-associated protein 1 light chain 3 (GFP-LC3) imaging, flow cytometry, Western blotting, and rapamycin rescue assays.</p><p><strong>Results: </strong>YSQYLSF reduced xenograft growth and, when combined with BO, produced a potent anti-tumor effect without significant weight loss or obvious liver and kidney damage. RNA-Seq identified 802 differentially expressed genes, with enrichment in mitogen-activated protein kinase (MAPK), mammalian target of rapamycin (mTOR), autophagy, apoptosis, inflammatory, and immune-related pathways. YSQYLSF increased the phosphorylated ERK/ERK and phosphorylated mTOR/mTOR ratios, decreased LC3-II/LC3-I, increased p62 accumulation, and enhanced the Bax/Bcl-2 and cleaved caspase-3/caspase-3 ratios. In vitro, YSQYLSF reduced H929 cell viability, decreased autophagosome formation, and promoted apoptosis. Rapamycin partially restored autophagy and attenuated apoptosis.</p><p><strong>Conclusions: </strong>YSQYLSF inhibits MM growth by activating the ERK/mTOR pathway, suppressing protective autophagy, and promoting mitochondrial apoptosis. Transcriptomic data also suggest additional immune- and inflammation-related mechanisms that require further validation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6834-6849"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norcantharidin induces apoptosis in hepatocellular carcinoma MHCC97-H cells in association with altered NF-κB/IκBα signaling dynamics and JNK activation.","authors":"Dong Wang, Jinbo Guo, Xiaolan Zhang, Fengrong Yin, Donglai Cui","doi":"10.62347/CLVD1603","DOIUrl":"10.62347/CLVD1603","url":null,"abstract":"<p><p>Norcantharidin (NCTD), a demethylated derivative of cantharidin, has antitumor activity against multiple cancer types; however, its effects on the NF-κB/JNK signaling axis in hepatocellular carcinoma (HCC) remain incompletely defined. MHCC97-H HCC cells were treated with NCTD at 5, 20, and 40 μg/mL (approximately 29.7, 118.9, and 237.9 μM), alone or in combination with pyrrolidine dithiocarbamate (PDTC, 50 μM), a compound with reported NF-κB inhibitory and antioxidant properties. NCTD suppressed cell viability in a dose- and time-dependent manner, with 48-h inhibition rates of 24.3%, 51.9%, and 72.1% at the three concentrations. Based on the available MTS data, the estimated NCTD IC50 was > 40 μg/mL at 24 h and approximately 19.0 μg/mL at 48 h. Flow cytometry showed corresponding apoptosis rates of 13.3%, 36.8%, and 43.2%, which increased to 50.2% after PDTC co-treatment. Western blotting showed reduced nuclear NF-κB p65 signal and decreased cytoplasmic IκBα levels, together with increased phosphorylated JNK (p-JNK), while total JNK remained unchanged. RT-qPCR showed upregulation of pro-apoptotic Bax, downregulation of anti-apoptotic Bcl-2, and increased c-Jun, TNF-α, and IL-6 transcripts. NCTD further impaired colony formation, induced G0/G1 arrest, depolarized mitochondrial membrane potential, and increased reactive oxygen species. TCGA-LIHC bulk RNA-seq data were analyzed to provide clinical context. NF-κB pathway genes were differentially expressed in HCC, and enrichment analyses implicated NF-κB, apoptosis, TNF, and MAPK-related pathways. The NF-κB Core activity score showed no significant tumor-normal difference, but immune infiltration analysis revealed associations between NF-κB activity and the HCC immune microenvironment. These findings indicate that NCTD triggers mitochondrial apoptosis in MHCC97-H cells in association with reduced nuclear p65 signal, altered IκBα turnover, stress/inflammatory gene induction, and enhanced JNK activation, rather than demonstrating uniform blockade of the entire NF-κB pathway.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7405-7419"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory role of the circHIPK3/miR-125a-5p/NDUFA5 axis in diabetic retinopathy: combined analysis of single-cell and bulk transcriptomes.","authors":"Zhihui Zhang, Yuanfeng Liu, Mei Bai","doi":"10.62347/FPHY7794","DOIUrl":"10.62347/FPHY7794","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the expression localization, functional effects, and upstream regulatory mechanism mediated by circHIPK3 (homeodomain interacting protein kinase 3)/miR-125a-5p of NDUFA5 (NADH-ubiquinone oxidoreductase 1 alpha subcomplex 5) in diabetic retinopathy (DR) by integrating public single-cell and bulk RNA-seq data with experimental validation, thereby providing a basis for investigating DR pathogenesis and identifying therapeutic targets.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;scRNA-seq data of DR were obtained from the GEO database, and differential expression of the key gene NDUFA5 was validated using bulk data. Human retinal microvascular endothelial cells (hRMECs) were exposed to 30 mmol/L glucose to establish a high-glucose (HG) cell model. NDUFA5 was knocked down in hRMECs. Cell viability was detected by Cell Counting Kit-8. The levels of oxidative stress indicators (malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GSH-Px]), and inflammatory factors (tumor necrosis factor α [TNF-α], interleukin-6 [IL-6]) were measured using ELISA. Cell migration ability was detected by Transwell assay, and tube formation ability was evaluated by tube formation assay. The expression levels of circHIPK3, miR-125a-5p, and NDUFA5 in cells were detected by RT-qPCR, and the protein expression of NDUFA5 was detected by western blot. The stability of circHIPK3 was assessed by actinomycin D treatment. RNA pull-down and dual-luciferase reporter gene assays were used to verify the binding relationships between circHIPK3/NDUFA5 and miR-125a-5p. The targeting relationship between miR-125a-5p and NDUFA5 was examined by overexpressing miR-125a-5p in HG cells. Combined inhibition of circHIPK3 and miR-125a-5p in HG cells were conducted to validate the above regulatory mechanism. Male C57BL/6J mice (6-8 weeks) were intraperitoneally injected with STZ to establish a DR mouse model. NDUFA5 was inhibited using intravitreal AAV (adeno-associated virus) injection. Retinal tissues were collected for molecular detection.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;scRNA-seq analysis revealed that NDUFA5 was specifically enriched in retinal rod cells of DR mice, forming an NDUFA5-enriched rod cell cluster (NDUFA5+RC) enriched in oxidative phosphorylation and HIF-1 signaling pathways. The VEGFA+MUC subpopulation in Müller cells was upregulated in the DR group, enriched in DR-related core pathologic pathways such as VEGF and PI3K/Akt signaling pathways, and bioinformatic prediction enhanced communication by the PTN-SDC4 ligand-receptor pair between VEGFA+MUC and NDUFA5+RC. Bulk RNA-seq validation confirmed that NDUFA5 expression was significantly upregulated in the DR group. Under HG conditions, NDUFA5 and circHIPK3 expression increased in hRMECs, while miR-125a-5p expression decreased. Knockdown of NDUFA5 or overexpression of miR-125a-5p significantly alleviated HG-induced cellular oxidative stress, inflammatory response, and abnormalities in","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6956-6973"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration inversely correlates with glucolipid metabolism in patients with new-onset type 2 diabetes mellitus.","authors":"Yulong He, Ting Ren","doi":"10.62347/IOPU3140","DOIUrl":"10.62347/IOPU3140","url":null,"abstract":"<p><strong>Objective: </strong>To study the correlation between sleep duration and glucolipid metabolism in patients with new-onset type 2 diabetes mellitus (NOT2DM).</p><p><strong>Methods: </strong>The participants were 168 NOT2DM patients. Glucolipid metabolism indices were compared among the short (n=59), middle (n=56), and long sleep groups (n=53), including fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), and triglyceride (TG). The correlation of sleep duration with glucolipid metabolism, glycemic control, and body fat distribution (abdominal total fat area [TFA] and visceral fat area [VFA]) was assessed. Finally, the contributors to poor glycemic control were explored.</p><p><strong>Results: </strong>Glucolipid metabolism indices tended to decrease with increasing sleep duration in NOT2DM patients, suggesting a significant negative correlation between sleep duration and glucolipid metabolism. The sleep duration of the good glycemic control group was significantly longer. A significant positive correlation was identified between sleep duration and good glycemic control, while an inverse association was determined between sleep duration and TFA. Body mass index (BMI), sleep duration, FBG, TG, and TFA were all independent contributors to poor glycemic control.</p><p><strong>Conclusions: </strong>Sleep duration in NOT2DM patients was inversely related to glucolipid metabolism and TFA and positively correlated with good glycemic control. High BMI, FBG, TG, and TFA, as well as short sleep duration, may increase the risk of poor glycemic control.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6866-6874"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multiparameter model combining ultrasound and maternal serum biomarkers accurately predicts late-onset fetal growth restriction.","authors":"Yaqin Li, Botao Yang, Liman Fu, Wei Zhang","doi":"10.62347/FAHT7495","DOIUrl":"10.62347/FAHT7495","url":null,"abstract":"<p><strong>Objectives: </strong>Late-onset fetal growth restriction (FGR) in pregnancy is frequently encountered and is linked to adverse perinatal results. This investigation aimed to evaluate the clinical use of a multiparameter model combining ultrasound features and maternal serum biomarkers for late-onset FGR.</p><p><strong>Methods: </strong>A retrospective investigation was conducted on 350 pregnant women in their third trimester who received standard prenatal care between January 2021 and December 2025. Participants were divided into a late-onset FGR group (n = 175) and a normal fetal development group (n = 175) according to the Chinese expert consensus criteria. Ultrasound findings including fetal biometry and Doppler flow indices were measured. Maternal serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PLGF) were quantified through enzyme-linked immunosorbent assay. Subsequently, the sFlt-1 to PLGF ratio (sFlt-1/PLGF) was calculated.</p><p><strong>Results: </strong>Among the 350 enrolled women, the FGR group exhibited markedly reduced abdominal circumference, estimated fetal weight, cerebroplacental ratio, and elevated uterine artery-pulsatility index and sFlt-1/PLGF compared to those in the normal group (all P < 0.05). The multiparameter evaluation model achieved an area under the curve of 0.977, demonstrating a sensitivity of 91.4% and specificity of 92.6% at the optimal threshold.</p><p><strong>Conclusions: </strong>The multiparameter model integrating ultrasound features and maternal serum biomarkers demonstrated excellent predictive performance for late-onset FGR, supporting its clinical use for early identification and management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6735-6745"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of acupoint catgut embedding combined with cyproterone acetate and ethinylestradiol plus metformin on sex hormones, glycolipid metabolism and insulin resistance in patients with polycystic ovary syndrome.","authors":"Ailing Zhao, Hong Qu, Ming Wei, Xuemei Zhang","doi":"10.62347/JGFM7966","DOIUrl":"10.62347/JGFM7966","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of acupoint catgut embedding combined with cyproterone acetate/ethinylestradiol and metformin in treating polycystic ovary syndrome (PCOS), focusing on sex hormones, glucose and lipid metabolism, and insulin resistance.</p><p><strong>Methods: </strong>This retrospective study included 311 PCOS patients (April 2023-July 2025). The control group (n=152) received sham embedding plus medications, while the intervention group (n=159) received authentic embedding plus same drugs over three menstrual cycles. Reproductive hormones, metabolic parameters, and HOMA-IR were assessed.</p><p><strong>Results: </strong>Baseline characteristics were comparable. Post-treatment, the intervention group showed significantly greater improvements in testosterone, luteinizing hormone, follicle-stimulating hormone, estradiol, fasting and postprandial glucose, lipid profile, and HOMA-IR than controls (all P<0.05). Menstrual recovery was superior (P<0.05). Clinical efficacy grading favored the intervention group (Z=2.401, P=0.016). Adverse events were similar between the groups (P=0.600). HOMA-IR correlated positively with testosterone, luteinizing hormone, total cholesterol, and triglycerides, but negatively with follicle-stimulating hormone, estradiol, and HDL-cholesterol (P<0.001).</p><p><strong>Conclusion: </strong>Acupoint catgut embedding combined with conventional pharmacotherapy synergistically improves hormonal dysregulation, metabolic disturbances, and insulin resistance in PCOS with a favorable safety profile.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6889-6900"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}