American journal of translational research最新文献_第6页

Therapeutic effects of transverse tibial bone transport in lower limb thromboangiitis obliterans. 胫骨横骨转运治疗下肢血栓闭塞性脉管炎的疗效。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/HAAJ5979

Minyou Hong, Qi Jin

{"title":"Therapeutic effects of transverse tibial bone transport in lower limb thromboangiitis obliterans.","authors":"Minyou Hong, Qi Jin","doi":"10.62347/HAAJ5979","DOIUrl":"10.62347/HAAJ5979","url":null,"abstract":"Objective: To investigate the treatment efficacy of transverse tibial bone transport (TTT) technique in patients with lower-limb thromboangiitis obliterans (LLTAO).Methods: A total of 119 patients diagnosed with LLTAO were selected for this retrospective study. Among them, 55 patients treated with conventional methods were assigned into the control group, while the other 64 patients treated with TTT technique were classified into the observation group. Systematic comparative evaluations were conducted between the two patient cohorts, analyzing four key domains: clinical recovery, hemorheological profile alterations, quality of life metrics, and treatment efficacy. Furthermore, we performed an exploratory analysis to identify determinants affecting therapeutic outcome.Results: The observation group showed significantly better outcomes than the control group in terms of functional recovery, hemorheological improvement, quality of life scores, and overall treatment effectiveness following the intervention. Univariate and multivariate analyses further demonstrated that age, pretreatment HBV, and treatment approach were all independent factors influencing treatment efficacy in these patients.Conclusion: The TTT technique exhibits superior therapeutic benefits for LLTAO patients over conventional intervention, establishing it as an effective treatment for this challenging condition.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4331-4340"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryoablation of parahisian premature ventricular contractions with an HD Grid multipolar mapping catheter: a case report. HD格网多极测图导管冷冻消融治疗先天性室性早搏1例。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/JVBD5542

Juan Chan, Ruikun Jia, Min Xu, Kaijun Cui

{"title":"Cryoablation of parahisian premature ventricular contractions with an HD Grid multipolar mapping catheter: a case report.","authors":"Juan Chan, Ruikun Jia, Min Xu, Kaijun Cui","doi":"10.62347/JVBD5542","DOIUrl":"10.62347/JVBD5542","url":null,"abstract":"Catheter ablation of premature ventricular contractions (PVCs) arising from the parahisian region poses considerable technical challenges due to the proximity of the His bundle, increasing the risk of atrioventricular (AV) block. We report the case of a 69-year-old woman with symptomatic, high-burden parahisian PVCs refractory to beta-blocker therapy. After structural heart disease was excluded through standard clinical evaluations, a combined approach using high-density mapping and cryoablation was adopted. Using an HD Grid multipolar mapping catheter, the earliest ventricular activation site was precisely identified near the His bundle, with a local activation time of -26 ms. After confirming safety with a test freeze, cryoablation was performed at -75°C for 480 seconds. The PVCs were successfully eliminated without any AV conduction disturbances. At the 12-month follow-up, the patient remained asymptomatic, and the PVC burden had decreased by more than 95%. This case demonstrates the safety and efficacy of combining HD Grid mapping with cryoablation for treating parahisian PVCs.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4788-4793"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early initiation of sacubitril/valsartan in STEMI patients improves ventricular remodeling. STEMI患者早期开始使用苏比利/缬沙坦可改善心室重构。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/NUKJ1589

Hongyuan Wang, Yanping Wang, Xinjun Zhang, Qiuxian Liu, Kun Zhang

{"title":"Early initiation of sacubitril/valsartan in STEMI patients improves ventricular remodeling.","authors":"Hongyuan Wang, Yanping Wang, Xinjun Zhang, Qiuxian Liu, Kun Zhang","doi":"10.62347/NUKJ1589","DOIUrl":"10.62347/NUKJ1589","url":null,"abstract":"Objective: To explore the effect of early administration (within 24 hours) of sacubitril/valsartan (Entresto) on left ventricular remodeling and prognosis in patients with ST-elevation myocardial infarction (STEMI).Methods: A retrospective study was conducted involving 150 STEMI patients diagnosed at Jiangshan People's Hospital between September 2021 and August 2023. Among them, 70 patients who received sacubitril/valsartan treatment were assigned as the observation group, and 80 patients treated with valsartan formed the control group. The echocardiographic parameters and biomarkers of cardiac injury were assessed in both groups.Results: The observation group exhibited improved left ventricular ejection fraction and reduced left atrial and ventricular diameters, along with a significant rise in stroke volume and reductions in left ventricular end-systolic and end-diastolic volumes. Cardiac injury biomarkers, including B-type natriuretic peptide and Troponin, significantly decreased in the observation group, while minimal changes were observed in the control group. Inflammatory markers, such as C-reactive protein, procalcitonin, and white blood cell count, were significantly reduced in the observation group. These findings underscore the efficacy of early sacubitril/valsartan treatment in improving outcomes for STEMI patients through enhanced ventricular function and reduced biomarkers of injury and inflammation.Conclusion: Early initiation of sacubitril/valsartan in STEMI patients significantly improves ventricular remodeling, as evidenced by enhanced echocardiographic parameters and reduced biomarkers, without increasing adverse events or compromising renal function.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4754-4763"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of interleukin-6 and interleukin-8 levels on pathogenic bacteria types in patients with advanced lung cancer and pulmonary infection during chemotherapy. 白细胞介素-6和白细胞介素-8水平对晚期肺癌患者化疗期间致病菌类型及肺部感染的影响

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/GRGQ7128

Xiaodan Zheng, Hongyun Lan, Yuhai Hu, Peifu Tian

{"title":"Effect of interleukin-6 and interleukin-8 levels on pathogenic bacteria types in patients with advanced lung cancer and pulmonary infection during chemotherapy.","authors":"Xiaodan Zheng, Hongyun Lan, Yuhai Hu, Peifu Tian","doi":"10.62347/GRGQ7128","DOIUrl":"10.62347/GRGQ7128","url":null,"abstract":"Objective: To investigate the levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in patients with advanced lung cancer complicated by pulmonary infection during chemotherapy and their effects on the type of pathogenic bacteria.Method: We retrospectively analyzed the clinical data of 196 patients from Wuhan Hankou Hospital (January 2021-June 2024). The incidence of pulmonary infection was assessed, and the levels of IL-6 and IL-8 were compared across different infection severities and pathogenic bacteria types. Spearman correlation analysis was used to determine associations, and logistic regression was performed to identify factors influencing different pathogenic bacteria infections.Result: The lung infection rate was 24.49% (48/196). Pathogenic bacteria included 36 strains (64.29%) of Gram-negative bacteria (G-) and 20 strains (35.71%) of Gram-positive bacteria (G+). The levels of IL-6 and IL-8 were significantly higher in infected patients than in uninfected patients (P < 0.05). These levels increased with the severity of infection and were positively correlated with the degree of infection. Elevated IL-6 and IL-8 levels were identified as independent risk factors for Gram-negative bacterial (G-) infections in patients with pulmonary infection. The combined AUC, sensitivity, and specificity of IL-6 and IL-8 were 0.925, 81.80%, and 93.33%, respectively.Conclusion: In patients with advanced-stage lung cancer undergoing chemotherapy, elevated IL-6 and IL-8 levels were closely associated with pulmonary infection severity. Detection of these cytokines may help differentiate the types of pathogenic bacteria causing lung infections.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4723-4732"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral calcar double-supported screw fixation enhances biomechanical stability in Pauwels type III femoral neck fractures: a comparative biomechanical study. 股骨跟双支撑螺钉固定增强Pauwels III型股骨颈骨折的生物力学稳定性：一项比较生物力学研究。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/OUBC8362

Xu-Chao Shi, Zhen-Tao Chu, Yi-Wen Yuan, Xiao-Long Xia, Wei-Long Li, Chuan-Bao Wang, Jiao-Jiao Hu

{"title":"Femoral calcar double-supported screw fixation enhances biomechanical stability in Pauwels type III femoral neck fractures: a comparative biomechanical study.","authors":"Xu-Chao Shi, Zhen-Tao Chu, Yi-Wen Yuan, Xiao-Long Xia, Wei-Long Li, Chuan-Bao Wang, Jiao-Jiao Hu","doi":"10.62347/OUBC8362","DOIUrl":"10.62347/OUBC8362","url":null,"abstract":"Objectives: This study proposed a novel fixation method - femoral calcar double-supported screw fixation (FCDSF) - and evaluated its biomechanical performance. The fixation's mechanical properties were assessed and compared with those of inverted triangular parallel cannulated screws (3CS) and biplane double-supported screw fixation (BDSF) for Pauwels type III femoral neck fractures (FNFs).Methods: Fifty-four synthetic femur models were allocated into three reduction groups simulating positive buttress, anatomical reduction, and negative buttress conditions. Each group was further divided into three subgroups (n = 6), fixed with FCDSF, 3CS, or BDSF. Torsional tests measured torque at the fracture site under 2° and 4° rotation. Load-to-failure tests were then conducted by applying continuous pressure until failure occurred, and the ultimate loads were recorded.Results: Under all reduction conditions, FCDSF demonstrated significantly greater torque at both rotation angles compared with 3CS (P < 0.05), while difference with BDSF was not statistically significant (P > 0.05). FCDSF showed superior load-bearing capacity over both BDSF and 3CS across all conditions (P < 0.05). In both the FCDSF and BDSF groups, positive buttress and anatomical reductions provided significantly better resistance to torsion and shear than negative buttress configurations (both P < 0.05), with no significant difference between the two (P > 0.05). In the 3CS group, only the positive buttress configuration showed a significant improvement over the negative buttress (P < 0.05).Conclusions: FCDSF provides enhanced anti-shear and anti-rotational stability compared with 3CS in managing Pauwels type III FNFs. Negative buttress reduction should be avoided due to its inferior biomechanical performance.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4445-4454"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Added administration of estradiol valerate tosurgical treatment for missed abortion in early pregnancy. 戊酸雌二醇在早期妊娠流产手术治疗中的应用。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/GVKI9955

Zhiquan Feng, Yiyun Zhang

{"title":"Added administration of estradiol valerate tosurgical treatment for missed abortion in early pregnancy.","authors":"Zhiquan Feng, Yiyun Zhang","doi":"10.62347/GVKI9955","DOIUrl":"10.62347/GVKI9955","url":null,"abstract":"Objective: To explore the clinical effect of different surgical methods for missed abortion in early pregnancy.Methods: In this retrospective study 100 patients diagnosed with early missed abortion were assigned to two groups based on the treatment modality. The operation group (n=50) underwent dilatation and curettage (D&C), while the combination group (n=50) received oral estradiol valerate prior to D&C. Clinical outcomes were compared between the two groups, including operative indexes, postoperative adverse events, cervical dilation effect, abortion outcomes, estrogen levels, endometria-related indexes, inflammatory markers, and levels of pregnancy associated protein A (PAPP-A).Results: Compared to the operation group, the combination group showed significantly reduced intraoperative blood loss, shorter durations of vaginal bleeding and operation time, greater postoperative endometrial thickness, and a lower incidence of postoperative intrauterine adhesions and total adverse events (all P<0.05). The total effective rate (χ2=4.320) and total abortion rate (Z=-3.525; χ2=5.020) were also significantly higher in the combination group. Moreover, the combination group exhibited higher postoperative levels of estradiol (E2), progesterone (P), β-human chorionic gonadotropin (β-hCG), and follicle-stimulating hormone (FSH), while levels of luteinizing hormone (LH), P, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and PAPP-A were lower (all P<0.05).Conclusion: Oral administration of estradiol valerate followed by D&C demonstrates superior clinical efficacy in the management of missed abortion during early pregnancy. This can enhance cervical dilation, facilitate abortion, modulate estrogen levels, promote endometrial repair, and relieve inflammation.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4827-4838"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness of the risk of monkeypox among men having sex with men: a cross-sectional survey in Chongqing, China. 男男性行为者对猴痘风险的认识：中国重庆的一项横断面调查

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/ADBC6620

Yiyang Wang, Xiao Liu, Li Qi, Jing Qin, Xiaoqing Tang, Xiaohua Wu, Shanquan Sun, Hui Xiang

{"title":"Awareness of the risk of monkeypox among men having sex with men: a cross-sectional survey in Chongqing, China.","authors":"Yiyang Wang, Xiao Liu, Li Qi, Jing Qin, Xiaoqing Tang, Xiaohua Wu, Shanquan Sun, Hui Xiang","doi":"10.62347/ADBC6620","DOIUrl":"10.62347/ADBC6620","url":null,"abstract":"Background: Monkeypox (Mpox) was declared a public health emergency by World Health Organization (WHO) in 2024. This study aimed to identify subpopulations of men who have sex with men (MSM) in Chongqing, China, who may perceive themselves to be at risk of Mpox infection.Methods: In September 2023, a cross-sectional online survey was conducted with the support of non-governmental organizations (NGOs). A total of 760 MSM were recruited to assess their socio-demographic characteristics, Mpox-related knowledge and awareness, risk perceptions, behavioral risk factors, and willingness to receive Mpox vaccination.Results: Among the participants, 219 (28.8%) were HIV-positive. Significant heterogeneity was observed across HIV statuses in terms of geographic origin, household registration, education level, income, sexual role, and other factors. After adjusting for age, a multivariable linear regression model revealed that Mpox risk perception was positively associated with higher levels of Mpox knowledge (β = -0.64, 95% confidence intervals (CI): -1.01 to -0.27, P < 0.001), experiences of stigma or discrimination (β = -0.20, 95% CI: -0.31 to -0.08, P < 0.001), and willingness to be vaccinated (β = 0.76, 95% CI: 0.64 to 0.88, P < 0.001). It was negatively associated with lower educational attainment and fewer high-risk sexual behaviors (β = 0.30, 95% CI: 0.12-0.48, P = 0.001).Conclusions: HIV-positive MSM, particularly those of lower socioeconomic status and educational attainment, tend to perceive themselves at lower risk of Mpox infection. Future interventions targeting MSM should focus on enhancing disease knowledge, fostering inclusive attitudes, and offering psychological support. Broader societal efforts to promote tolerance and reduce stigma are also essential.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4493-4505"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia. 高磷酸盐对Sirtuin 3的调节：肌肉老化和肌肉减少症的潜在机制。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/JWEY8421

Chao Xu, Ling Xiong, Junhu Chen, Qingcheng Liu, Fang Wang, Xianxian Fu, Juan Huo, Yufei Bu, Shiyu Chen, Qian Liu

{"title":"Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia.","authors":"Chao Xu, Ling Xiong, Junhu Chen, Qingcheng Liu, Fang Wang, Xianxian Fu, Juan Huo, Yufei Bu, Shiyu Chen, Qian Liu","doi":"10.62347/JWEY8421","DOIUrl":"10.62347/JWEY8421","url":null,"abstract":"Objectives: To investigate the role of elevated phosphate levels in muscle aging, and to elucidate the underlying molecular mechanisms by which high phosphate conditions regulate muscle aging and explore the potential therapeutic role of SIRT3 activation.Methods: Young (5-month-old) and aged (24-month-old) C57BL/6 mice were compared in terms of body weight, muscle strength, and serum sodium levels. Additionally, C2C12 myoblasts were exposed to 20 mM β-glycerophosphate (BGP) to simulate high phosphate conditions. Cellular senescence was assessed using senescence-associated β-galactosidase (SA-β-GAL) staining and Western blot analysis (P53, P62, and P21). The role of SIRT3 in muscle cell senescence was further investigated by treating C2C12 cells with the SIRT3 activator 2-APQC.Results: Aged mice exhibited significantly higher body weight, reduced grip strength, and elevated serum sodium levels compared to young mice, indicating muscle aging. BGP treatment in C2C12 cells induced cellular senescence, as evidenced by elevated SA-β-GAL activity and upregulation of senescence markers P53, P62, and P21. Furthermore, high phosphate levels impaired cell migration and differentiation. Activation of SIRT3 by 2-APQC alleviated these effects, restoring autophagic activity and reversing muscle cell dysfunction.Conclusions: Elevated serum sodium and phosphate levels are associated with muscle aging in mice. High phosphate induces cellular senescence and impairs muscle function, while SIRT3 activation mitigates these effects, highlighting its potential as a therapeutic target for sarcopenia. Dietary phosphate restriction and activation of SIRT3 may represent effective strategies for combating age-related muscle degeneration.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4187-4197"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superior diagnostic performance of computed tomography over abdominal ultrasound for ovarian cancer detection. 计算机断层扫描对卵巢癌的诊断优于腹部超声。

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/FEQD5607

Ming Wu, Hui Zhang, Si Wang, Guangjin Bao

{"title":"Superior diagnostic performance of computed tomography over abdominal ultrasound for ovarian cancer detection.","authors":"Ming Wu, Hui Zhang, Si Wang, Guangjin Bao","doi":"10.62347/FEQD5607","DOIUrl":"10.62347/FEQD5607","url":null,"abstract":"Objective: To evaluate the clinical use of computed tomography (CT) in diagnosis of ovarian cancer.Methods: This retrospective study included 120 patients diagnosed with ovarian cancer between January 2021 and June 2024. All patients underwent both abdominal ultrasound and computed tomography (CT) examinations. Diagnostic performance, including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy, were compared between the two modalities.Results: CT demonstrated superior diagnostic performance compared to abdominal ultrasound in all evaluated criteria. Specifically, CT exhibited higher sensitivity, specificity, PPV, and NPV. In addition, CT demonstrated superior performance for assessing tumor characteristics, a solid component, peritoneal involvement, lymph node metastasis, tumor vascularity, metastasis, and ovarian cystic lesions. Statistically significant differences were observed in the diagnostic accuracy for both early- and advanced-stages of ovarian cancer, highlighting CT's ability to deliver more accurate, reliable, and comprehensive information compared to ultrasound.Conclusion: CT outperformed abdominal ultrasound in diagnosing ovarian cancer, demonstrating superior sensitivity, specificity, and definition of tumor characteristics, metastasis, peritoneal involvement, and lymph node detection.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4849-4858"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonlinear relationship between TyG index and the risk of non-alcoholic fatty liver disease in Chinese population: a cross-sectional study. TyG指数与中国人群非酒精性脂肪肝风险的非线性关系：一项横断面研究

IF 1.7 4区医学

American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.62347/EXFN1219

Tuo Han, Bao'e Yan, Jing Xiao, Xiyu Gao, Ying Li, Qian Wang, Chunyan Zhang, Yan Zhang

{"title":"Nonlinear relationship between TyG index and the risk of non-alcoholic fatty liver disease in Chinese population: a cross-sectional study.","authors":"Tuo Han, Bao'e Yan, Jing Xiao, Xiyu Gao, Ying Li, Qian Wang, Chunyan Zhang, Yan Zhang","doi":"10.62347/EXFN1219","DOIUrl":"10.62347/EXFN1219","url":null,"abstract":"Background: There is insufficient evidence on the link between the triglyceride-glucose index (TyG) and non-alcoholic fatty liver disease (NAFLD) in the Chinese population. This study aims to investigate the association between TyG and the risk of NAFLD.Methods: A cross-sectional study was conducted with 994 participants who underwent health examinations. Demographic information, blood biochemistry profiles, and ultrasonics results were collected. Logistic regression and restricted cubic spline (RCS) analysis was used to assess the nonlinear relationship between TyG and NAFLD risk. Subgroup analysis was performed to examine possible interaction effects.Results: Overall, 31.2% (n = 314) of the general population had NAFLD. Age, male gender, BMI, blood pressure, alanine aminotransferase, fasting blood glucose, uric acid, triglycerides and TyG levels were associated with NAFLD. RCS analysis showed a significant nonlinear dose-response relationship between TyG index and NAFLD. The risk of developing NAFLD increases significantly with a higher TyG index. This association persists even after adjustment for relevant risk factors [odds ratio (OR): 4.70, 95% CI 3.24 to 6.83]. Furthermore, compared to the lowest quartile of TyG (Q1), the NAFLD risk of subjects in the Q2, Q3, and Q4 quartiles increased 1.53, 3.84, and 16.07 times, respectively (P for trend < 0.001). Furthermore, statistically significant interactions were observed between TyG index and gender, BMI, and hypertension in predicting NAFLD risk (P < 0.05).Conclusions: This study highlights the impact of an elevated TyG index on the risk of developing NAFLD. Elevated TyG levels may serve as a risk factor for NAFLD in the Chinese population.","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4315-4322"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0