American journal of translational research最新文献

{"title":"Analysis of short-term efficacy and rebleeding risk in aneurysmal subarachnoid hemorrhage patients undergoing vascular intervention.","authors":"Zhiqiang Ye, Huanyu Tang, Shiming Xia, Xiaoping Tang","doi":"10.62347/AEWG1973","DOIUrl":"https://doi.org/10.62347/AEWG1973","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the short-term efficacy and rebleeding risk of vascular intervention in patients with aneurysmal subarachnoid hemorrhage (aSAH).</p><p><strong>Methods: </strong>This retrospective study included 98 aSAH patients treated between August 2020 and May 2023. Based on the treatment method, patients were divided into an interventional group (n = 50, treated with endovascular embolization) and a craniotomy group (n = 48, treated with microsurgical clipping). Surgical parameters, clinical outcomes, immune markers, prognosis scores, cognitive function, and safety were compared using t-tests or chi-square tests. Binary logistic regression identified independent risk factors for clinical outcomes and rebleeding.</p><p><strong>Results: </strong>The interventional group showed significantly less intraoperative blood loss, shorter hospital stays, and shorter operative times compared to the craniotomy group (all <i>P</i> < 0.05). Clinical outcomes and Glasgow Outcome Scale scores were better in the interventional group (all P < 0.05). At 3 days and 3 months post-surgery, immune markers (IgG, IgA, IgM) were significantly higher in the interventional group (all P < 0.05). Additionally, MMSE scores at 3 days post-surgery were higher, and the incidence of postoperative cognitive dysfunction within 3 months was lower (both P < 0.05). The complication rate was significantly lower in the interventional group (12.00% vs. 37.50%, P < 0.05). Preoperative Hunt-Hess grade, surgical approach, age, and postoperative complications were identified as independent risk factors for prognosis (all P < 0.05), while surgical approach, age, and Hunt-Hess grade were risk factors for rebleeding (all P < 0.05).</p><p><strong>Conclusion: </strong>Vascular intervention provides superior short-term efficacy in aSAH patients, with faster recovery, reduced surgical trauma, and better clinical outcomes compared to craniotomy. Monitoring should be intensified for older patients and those with higher preoperative Hunt-Hess grades to minimize the risks of poor prognosis and rebleeding.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3322-3332"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of a self-made liver suspension device in 3D laparoscopic non-anatomical resection of liver segment VI and VII tumors.","authors":"Shengxiong Chen, Xiaoxu Jin, Zijia Hao, Yijun Wang, Chengxu Du, Xiaoding Liu, Huiqing Jiang","doi":"10.62347/FEMB3665","DOIUrl":"https://doi.org/10.62347/FEMB3665","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of a novel self-designed liver suspension device in three-dimensional (3D) laparoscopic non-anatomical (NAR) resection for tumors in hepatic segments VI and VII.</p><p><strong>Methods: </strong>Clinical records of 79 patients undergoing NAR resection of hepatic segments VI and VII at the Second Hospital of Hebei Medical University (June 2016-December 2021) were retrospectively reviewed. Patients were stratified into the Suspension Device Laparoscopic Group (SDLG), utilizing the self-designed suspension device for 3D-guided resection, and the Conventional Laparoscopic Group (CLG). Statistical analyses comprised two-sample t-tests, chi-square tests, and Log-rank tests. Perioperative outcomes including surgical time, hepatic pedicle occlusion time, intraoperative blood loss, postoperative hospital stay, drainage tube removal time, time to ambulation, postoperative flatus recovery, and complications (pleural effusion, ascites, bile leakage, wound infection/liquefaction/effusion) were compared. Postoperative hepatic functional recovery (Child-Pugh classification) and 1-/3-year survival rates were assessed.</p><p><strong>Results: </strong>The SDLG demonstrated significantly shorter surgical time, reduced intraoperative blood loss, and abbreviated hepatic pedicle clamping time compared to the CLG. Postoperative hepatic functional recovery, as assessed by Child-Pugh classification, was accelerated in the SDLG cohort, with a higher proportion achieving baseline function earlier than the CLG. Complication rates, including pleural effusion, ascites, and bile leakage, were markedly lower in the SDLG, while no significant differences were observed in hospitalization duration, ambulation initiation, or flatus recovery. Survival analysis revealed the 1-/3-year survival rate of SDLG was higher than that of CLG.</p><p><strong>Conclusion: </strong>The self-designed liver suspension device enhances the safety and efficiency of 3D laparoscopic NAR resection for hepatic segment VI and VII tumors by minimizing operative trauma, reducing mechanical injury risks, and promoting postoperative hepatic functional recovery. Its application is associated with fewer procedure-related complications to conventional techniques, and increased survival rate. These advantages underscore its potential as a valuable innovation in minimally invasive liver surgery, meriting further clinical validation and integration with complementary technologies to refine surgical precision and outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3862-3874"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a clinical predictive model for risk factors after laparoscopic surgery in patients with endometriosis based on pathologic characteristics.","authors":"Fang Li, Yunxiu Fan, Yanni Huang, Juan Yan, Hui Yang, Xin Yang, Wenli Qiao, Hua Chen, Haifeng Jiang, Na Zhao","doi":"10.62347/PINL7923","DOIUrl":"https://doi.org/10.62347/PINL7923","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between preoperative pathologic characteristics and the risk of postoperative recurrence in endometriosis (EMs) patients, and to develop a clinical predictive model.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 164 EMs patients who underwent laparoscopic surgery between January 2022 and December 2023 at Peking University First Hospital Ningxia Women and Children's Hospital. Demographic and clinicopathologic data were collected, and patients were stratified by one-year recurrence status. Multivariable logistic regression identified independent recurrence risk factors, and a predictive nomogram was constructed. Model performance was evaluated using ROC curves, the Hosmer-Lemeshow goodness-of-fit test (HLGOF), calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>Postoperative recurrence occurred in 46 patients (28%) within one year. Univariate analysis revealed associations between recurrence and factors including dysmenorrhea history, abortion, pathologic type, American Society for Reproductive Medicine (ASRM) stage, abnormal uterine bleeding, posterior fornix tender nodules, uterine enlargement, accessory area thickening, and delivery history (all P<0.05). Multivariate analysis confirmed that abortion (OR=1.31), ASRM stage ≥III (OR=1.03), abnormal uterine bleeding (OR=1.72), and posterior fornix tender nodules (OR=1.34) were independent predictors (all P<0.05). The nomogram (Logit (P)=-3.30+1.31X₁+1.03X₂+1.72X₃+1.34X₄) demonstrated an AUC of 0.802, with 71% sensitivity and 76% specificity. The HLGOF and calibration curves indicated that the predicted values were not significantly different from the observed values, showing good model fit (H-L, P>0.05).</p><p><strong>Conclusion: </strong>Preoperative pathologic features are significant predictors of recurrence after laparoscopic surgery for EMs. Monitoring these markers can help clinicians identify high-risk patients and provide more targeted treatment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3392-3403"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor site outcomes and functional recovery are improved with superficial inferior epigastric artery perforator flap compared to radial forearm flap in oral and maxillofacial reconstruction.","authors":"Jian Sun, Ying Huang, Yixi Wang, Daihong Liu, Hui Zhao","doi":"10.62347/GYJH5711","DOIUrl":"https://doi.org/10.62347/GYJH5711","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of the superficial inferior epigastric artery perforator (SIEA) flap and radial forearm (FA) flap in reconstructing oral and maxillofacial soft tissue defects, with emphasis on donor site complications, functional recovery, aesthetic outcomes, and quality of life.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 204 patients who underwent SIEA (n = 104) or FA (n = 100) flap reconstruction between 2014 and 2023. Outcomes assessed included flap survival, donor site complications (scarring, sensory abnormalities), functional recovery (mouth opening, speech clarity), and quality of life (based on UW-QOL). Statistical analysis included chi-square tests, t-tests, and logistic regression.</p><p><strong>Results: </strong>Flap survival rates were similar between groups (P = 0.411). However, the SIEA group exhibited significantly better donor site outcomes: fewer sensory abnormalities (P < 0.001), less severe scarring (P < 0.001), and greater aesthetic satisfaction (P = 0.027). Functional outcomes also favored the SIEA flap, with improved mouth opening (P = 0.024) and speech clarity (P < 0.001). However, SIEA reconstruction required longer operative time (P < 0.001). Independent risk factors for delayed donor site healing included age ≥ 60 years, BMI ≥ 23 kg/m², smoking, diabetes, and extended hospitalization.</p><p><strong>Conclusion: </strong>The SIEA flap offers superior donor site aesthetics, sensory preservation, and functional recovery compared to the FA flap, though it is associated with longer operative time. The FA flap remains a reliable option. Preoperative planning should consider individualized flap selection based on vascular anatomy, comorbidities, and aesthetic goals.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3790-3801"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luteolin alleviates Herpes Simplex Keratitis by inhibiting inflammatory responses via suppressing the PTGS2/NF-κB signaling pathway.","authors":"Xudong Zhao, Zhichao Ren, Dingwen Cao, Yusen Huang","doi":"10.62347/IQUZ8416","DOIUrl":"https://doi.org/10.62347/IQUZ8416","url":null,"abstract":"<p><strong>Objective: </strong>Herpes Simplex Keratitis (HSK) is a leading cause of infectious-related blindness, primarily driven by corneal inflammation and dysregulated immune response. Luteolin (LUT), a flavonoid with anti-inflammatory and antiviral properties, has the potential to target key signaling pathways and provide therapeutic benefits. This study aimed to investigate the mechanisms through which LUT alleviates HSK.</p><p><strong>Methods: </strong>LUT's potential targets in HSK were identified using a systemic biology approach. Protein-Protein Interaction (PPI) analysis was performed to determine key hub genes. Molecular docking was used to assess LUT's binding affinity to PTGS2 and other key proteins. HSK mice were treated with LUT, and corneal opacity, edema, and thickness were then evaluated using slit-lamp microscopy and Optical Coherence Tomography. Inflammatory cytokine levels were quantified by quantitative Real-Time Polymerase Chain Reaction PCR (qRT-PCR), while PTGS2/NF-κB pathway activation, PTGS2 expression, and NF-κB phosphorylation levels were assessed by Western Blotting (WB).</p><p><strong>Results: </strong>LUT was found to regulate 30 HSK-related proteins, with AKT1, TNF, and PTGS2/NF-κB identified as key nodes. Furthermore, molecular docking confirmed a strong binding to PTGS2 (-9.7 kcal/mol). LUT treatment significantly reduced corneal opacity and edema, restoring corneal thickness to near-normal levels. RT-qPCR revealed downregulation of inflammatory cytokines, and WB analysis showed decreased PTGS2 expression and NF-κB phosphorylation, confirming LUT's role in attenuating corneal inflammation via inhibiting the PTGS2/NF-κB signaling pathway.</p><p><strong>Conclusions: </strong>LUT alleviates HSK by modulating the PTGS2/NF-κB signaling pathway, reducing inflammation and corneal damage, and highlighting its therapeutic potential for ocular inflammatory diseases.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3307-3321"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic and therapeutic process of invasive encapsulated follicular variant of papillary thyroid carcinoma with lung metastasis: a case report.","authors":"Yuling Dong, Fuxue Tang, Jianxin Hu, Jie Zhang","doi":"10.62347/LROE2153","DOIUrl":"https://doi.org/10.62347/LROE2153","url":null,"abstract":"<p><p>The invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) is a subtype of papillary thyroid carcinoma (PTC) that is often clinically misdiagnosed as a benign lesion. This case report describes a case of IEFVPTC with lung metastasis, highlighting its pathological features and treatment process to enhance understanding of this disease. A female patient discovered to have a thyroid nodule during a routine physical examination sought evaluation and treatment at our hospital. Fine-needle aspiration of the left thyroid lobe and left cervical lymph node confirmed a diagnosis of the macrofollicular variant of IEFVPTC. Computed Tomography (CT) scans indicated pulmonary metastasis, and the patient underwent tumor excision followed by three courses of radioiodine-131 (I-131) therapy. After treatment, no new lymph node metastases were detected, and both the size and lung metastatic lesions significantly decreased. When thyroid lesions present as nodular hyperplasia, characterized by predominantly large follicles or macrofollicular structures rich in colloid, papillary proliferation of the follicular epithelium and cytological features such as ground-glass nuclei and nuclear grooves, one suspects the possibility of IEFVPTC. Clinical assessment, ultrasound examination, and immunohistochemical staining are often combined to aid in diagnosis, reducing the likelihood of missed cases of IEFVPTC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3560-3564"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and efficacy of remimazolam for anesthesia monitoring in transcatheter aortic valve implantation via femoral artery access.","authors":"Xin Liang, Xin Deng, Qiying Lao, Longqian Chen, Yanli Liang, Liu Yang","doi":"10.62347/QUMD4078","DOIUrl":"https://doi.org/10.62347/QUMD4078","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of remimazolam during anesthesia monitoring in transcatheter aortic valve implantation (TAVI) via femoral artery catheter (FAC).</p><p><strong>Methods: </strong>We reviewed the medical records of 50 patients who underwent TAVI via FAC from July 2022 to September 2023. Patients were divided into two groups: a control group (receiving propofol, n=25) and a remimazolam group (receiving remimazolam, n=25). Pulse oxygen saturation (SpO₂), heart rate (HR), mean arterial pressure (MAP) and Bispectral Index (BIS) were recorded at various time points: 5 min before anesthesia (T0), 0 (T1), 5 (T2), 10 (T3), 15 (T4), and 20 min (T5) after infusion. Operation time, blood loss, awakening time, quality of recovery (QoR-15) scores before operation and 1 and 3 days after operation were recorded and compared between the two groups. Additionally, the incidence of delirium at 1-day post-operation was compared between the two groups. The incidence of adverse reactions and patient satisfaction were compared between the groups.</p><p><strong>Results: </strong>At T2, T3, T4 and T5, the remimazolam group exhibited significantly higher SpO₂, HR and MAP than the control group (P<0.05); BIS values and modified observer's assessment of alertness/sedation (MOAA/S) scores showed no significant differences (P>0.05). The remimazolam group also had significantly earlier awakening times (P<0.05), without differences in operation time or blood loss (P<0.05). QoR-15 scores at 1 and 3 days post-operation were higher in the remimazolam group (P<0.05). The incidence of postoperative delirium was slightly lower in the remimazolam group (P>0.05). The control group had a higher total incidence of adverse reactions and lower satisfaction compared to the remimazolam group (P<0.05).</p><p><strong>Conclusion: </strong>Remimazolam is an effective sedative for TAVI anesthesia, associated with lower postoperative adverse reactions, thus facilitating better recovery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3530-3537"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast skin merkel cell carcinoma: a case report.","authors":"Xinming Hou, Qian Lv, Zhaobao Lv","doi":"10.62347/YFTJ3672","DOIUrl":"https://doi.org/10.62347/YFTJ3672","url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin malignancy characterized by high recurrence and metastasis rates. Here, we present a case of primary breast skin MCC in a 65-year-old female patient who initially presented with a peanut-sized lump on her right breast, which rapidly developed into a cauliflower-like mass accompanied by intermittent pain. The patient underwent radical surgery (right mastectomy and right axillary lymph node dissection), followed by postoperative chemotherapy. Immunohistochemical examination revealed positive staining for Cytokeratin 20 (CK20), Synaptophysin (Syn), Cluster of Differentiation 56 (CD56), and Chromogranin A (CgA), confirming the diagnosis of MCC. A subsequent Positron Emission Tomography - Computed Tomography (PET-CT) scan revealed secondary liver metastasis. Despite an initial effective response to chemotherapy, the patient developed severe bone marrow suppression, necessitating a switch to maintenance therapy with capecitabine.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3554-3559"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of three whitening protocols for mild-to-moderate dental fluorosis in anterior teeth.","authors":"Meixi Zhou, Linhong Zhu, Hua Lan","doi":"10.62347/RKQX9577","DOIUrl":"https://doi.org/10.62347/RKQX9577","url":null,"abstract":"<p><strong>Objective: </strong>This research compares the effectiveness of three whitening treatments for mild-to-moderate dental fluorosis in the front teeth.</p><p><strong>Method: </strong>This retrospective study analysis is based on 51 mild-to-moderate dental fluorosis cases. The patients who visited the Dental Hospital of Ningxia Medical University from August 2020 to August 2021 were enrolled as research cases. The patients were classified into three groups according to their treatment plans: Group A (19 cases), Group B (17 cases), and Group C (15 cases). The upper anterior teeth color was assessed immediately after treatment and then at one week, one month, three months, and six months using the VITA Easyshade^® V shade guide. Tooth sensitivity was evaluated with a visual analog scale (VAS scale).</p><p><strong>Results: </strong>Three options were applied to treat mild and moderate dental fluorosis. Moderate fluorosis showed higher ΔE and ΔL values but lower Δa and Δb values compared to mild fluorosis, with significant differences noted (P<0.05). In cases of mild dental fluorosis, ΔE and ΔL values from the combination of micro-grinding and home bleaching were significantly higher. Conversely, Δa and Δb values for both micro-grinding with home bleaching and micro-grinding with combined bleaching were significantly lower (P<0.05). In moderate dental fluorosis cases, ΔE and ΔL values were higher for both micro-grinding combined with bleaching and micro-grinding combined with home bleaching. In contrast, Δa and Δb values for micro-grinding combined with bleaching were lower, showing statistically significant differences (P<0.05). The sensitivity of micro-grinding + home bleaching was less than that of micro-grinding + in-office bleaching and micro-grinding + combined bleaching immediately post-op, 1 week after the operation, with statistically significant differences (P<0.05).</p><p><strong>Conclusion: </strong>All three options achieve sound whitening effects for mild to moderate dental fluorosis in anterior teeth. The whitening effect is more effective in cases of moderate dental fluorosis than in mild cases. Among the three treatment options, microabrasion combined with home bleaching achieves the best whitening effect for mild dental fluorosis and minimizes sensitivity. When considering the three treatment options for moderate dental fluorosis, both microabrasion combined with home bleaching and microabrasion combined with in-office bleaching can yield better whitening effects. However, it is essential to note that the latter option is linked to higher sensitivity.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3454-3464"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of survival benefit and safety profile between lenvatinib and donafenib as conversion therapy in patients with hepatocellular carcinoma.","authors":"Yuehong Hou, Zhenlin Gao, Yaguang Han, Ci Liu, Xiaojuan Su, Dongliang Zhang","doi":"10.62347/PBLA2928","DOIUrl":"https://doi.org/10.62347/PBLA2928","url":null,"abstract":"<p><strong>Objective: </strong>To compare the survival benefit and safety profiles between lenvatinib and donafenib when used as conversion therapies for patients with hepatocellular carcinoma (HCC) at the China National Liver Cancer (CNLC) stages I-III.</p><p><strong>Methods: </strong>A retrospective comparative study was conducted on 76 patients diagnosed with HCC at CNLC stage I-III. Among them, 40 patients were treated with lenvatinib, and the other 36 patients received donafenib. Key outcomes, including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and adverse events, were evaluated.</p><p><strong>Results: </strong>Patients treated with lenvatinib showed significantly longer OS (14.9 vs. 7.9 months, <i>P</i>=0.010) and PFS (4.6 vs. 2.9 months, <i>P</i><0.001) compared to those treated with donafenib. The ORR was 15% in the lenvatinib group and 5.6% in the donafenib group (<i>P</i>=0.551). Lenvatinib was also associated with a lower incidence of grade ≥3 adverse events (<i>P</i><0.05). Specifically, severe adverse events such as hepatotoxicity, hematological toxicity, hand-foot syndrome, and diarrhea were less frequent in the lenvatinib cohort. Univariate and multivariate analyses identified elevated alpha-fetoprotein (AFP) levels and the presence of hepatic vein tumor thrombus as significant predictors of poorer PFS, with hazard ratios (HR) of 1.45 and 1.80, respectively. Furthermore, multivariate analysis revealed that higher Child-Pugh scores and elevated AFP levels were associated with worse OS (all <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Lenvatinib demonstrates superior survival outcomes compared to donafenib as a conversion therapy in patients with CNLC stage I-III HCC. While the two therapies are comparable in overall safety profiles, lenvatinib is more tolerated, with a lower incidence of severe adverse events.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3496-3504"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}