American journal of translational research最新文献

{"title":"Twelve Shugan Lidan Granules from traditional Chinese medicine can improve liver function in patients with postoperative hepatolithiasis by inhibiting the Hippo signaling pathway.","authors":"Lixiang Li, Xiaoyong Niu, Wanzong Zhang, Ziyu Wang, Shengming Zhang, Qi Zhang, Wei Qi, Wenshan Jing, Gaobin Hu, Long Huang, Ziyi Li, Qiyu Feng, Hui Peng, Qingsheng Yu","doi":"10.62347/VXHU6738","DOIUrl":"10.62347/VXHU6738","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatolithiasis (HL) is a complex liver and biliary disorder characterized by high rates of recurrence. This study aimed to evaluate the efficacy of Twelve Shugan Lidan Granules (TSLG), a compound herbal traditional Chinese formulation, in the treatment of HL, as well as to investigate its underlying mechanism.</p><p><strong>Methods: </strong>A retrospective analysis was conducted involving 157 patients diagnosed with HL, who were divided into two groups: the control group and the research group. In the control group, no treatment was given postoperatively, while in the research group, TSLG was orally administered three times a day postoperatively for two months. Both groups were followed up by telephone at 1 month, 2 months, and 3 months postoperatively. Liver function indicators were measured before and after surgery, and miRNA expression profiling was analyzed using high-throughput sequencing (HTS). Additionally, the expression levels of related proteins were assessed through western blots.</p><p><strong>Results: </strong>Postoperative liver function indicators were significantly lower in the research group compared to the control group (P < 0.05). Additionally, 64 miRNAs were differentially expressed in HL patients. Further analysis of 64 miRNAs revealed their abnormal targeting of the Hippo signaling pathway. Further experimental results indicate that TAZ protein expression is elevated in HL patients, reflecting abnormal activation of the Hippo signaling pathway in these patients. TSLG treatment significantly reduced the expression of YAP, TAZ, and SREBP-2 proteins, while increasing the expression of p-YAP and p-TAZ proteins (all P < 0.05). Furthermore, TSLG inhibited the Extracellular Acidification Rate (ECAR) in LPS-induced WRL68 cells.</p><p><strong>Conclusion: </strong>TSLG effectively improved postoperative liver function by downregulating sterol regulatory element-binding protein-2 (SREBP-2) and inhibiting the Hippo signaling pathway.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"7186-7199"},"PeriodicalIF":1.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic materials science reconsidered.","authors":"Futian Dong","doi":"10.62347/WKWE7595","DOIUrl":"10.62347/WKWE7595","url":null,"abstract":"<p><p>Bioinformatic materials science integrates medical science, materials science, informatics, and other disciplines, aiming to maintain the balance of tissues and organs in the human body. This paper explores the relationship between structural information and the structures synthesized through regulated gene expression. Specifically, it describes the transformation of information into substances via biological structural systems, using mathematical formulas to develop bioinformatic materials. These materials have applications in medical treatments, functional foods for preventive healthcare, and cosmetic products for health maintenance. Notably, bioinformatic materials have been applied in treating acromegaly, a rare and life-threatening disease of unknown etiology, and have improved the neurofilament light chain (NFL) index and typical symptoms of Amyotrophic Lateral Sclerosis (ALS). In summary, bioinformatic materials science holds potential for enhancing human health and contributing to advances in medicine.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"7200-7204"},"PeriodicalIF":1.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Transplantation of bone marrow-derived mesenchymal stem cells rescues partially rachitic phenotypes induced by 1,25-Dihydroxyvitamin D deficiency in mice.","authors":"Zengli Zhang, Shaomeng Yin, Xian Xue, Ji Ji, Jian Tong, David Goltzman, Dengshun Miao","doi":"10.62347/OLIL8708","DOIUrl":"10.62347/OLIL8708","url":null,"abstract":"<p><p>[This corrects the article on p. 4382 in vol. 8, PMID: 27830022.].</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"7205-7207"},"PeriodicalIF":1.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pulmonary rehabilitation training on postoperative recovery in lung cancer patients undergoing thoracoscopic partial pulmonary resection: a meta-analysis.","authors":"Tianyun Duan, Yinan Guo, Qin Lu, Hongying Pan","doi":"10.62347/NJRM6592","DOIUrl":"https://doi.org/10.62347/NJRM6592","url":null,"abstract":"<p><strong>Objective: </strong>To systematically analyze the impact of pulmonary rehabilitation (PR) on postoperative recovery of lung cancer patients undergoing thoracoscopic partial pulmonary resection.</p><p><strong>Methods: </strong>This study has been registered with PROSPERO (CRD42024574965). A comprehensive search was conducted in PubMed, The Cochrane Library, Embase, Web of Science and CINAHL for literature on the effects of PR on postoperative rehabilitation in lung cancer patients undergoing thoracoscopic partial pulmonary resection, up to May 2024. Studies meeting the inclusion and exclusion criteria were selected for the meta-analysis. Valid data were extracted, and the integrated analysis was performed using RevMan5.3 and Stata 12.0 software.</p><p><strong>Results: </strong>A total of 10 relevant studies, involving 677 subjects, were included. Of these, 341 patients were in the experimental group, and 336 were in the control group. The meta-analysis showed that PR significantly improved the forced expiratory volume in the first second after surgery (FEV1) [<i>SMD</i>=1.73, 95% CI: (0.52-2.94)], peak expiratory flow (PEF) [<i>SMD</i>=0.45, 95% CI: (0.12-0.78)], forced vital capacity (FVC) [SMD=4.31, 95% CI: (1.98-6.63)], and 6 min walking distance (6MWD) [<i>SMD</i>=1.64, 95% CI: (0.64-2.65)]. PR also reduced the incidence of postoperative complications [<i>OR</i>=0.28, 95% CI: (0.18-0.43)] and shortened the duration of postoperative hospitalization [<i>SMD</i>=-0.56, 95% CI: (-0.88 - -0.24)] in lung cancer patients undergoing thoracoscopic partial pulmonary resection. There was no significant difference in anxiety [<i>SMD</i>=-0.34, 95% CI: (-1.27-0.60)] or depression [<i>SMD</i>=-0.15, 95% CI: (-0.48-0.18)] between the two groups.</p><p><strong>Conclusion: </strong>PR improves lung function and exercise tolerance, reduces postoperative complications, and shortens postoperative hospital stays in lung cancer patients undergoing thoracoscopic partial pulmonary resection. However, its effect on reducing negative mood remains unclear. Due to the limitations in the number and quality of included studies, further high-quality studies are needed to validate these findings.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6168-6186"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.","authors":"Hang Shu, Xiaoyu Chen, Jie Zhao, Ping Li, Zhen Sun","doi":"10.62347/JRDP4018","DOIUrl":"10.62347/JRDP4018","url":null,"abstract":"<p><strong>Background: </strong>Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation and metastasis. Protein Inhibitor of Activated STAT (PIAS) family genes, comprising PIAS1, PIAS2, PIAS3, and PIAS4, are emerging as significant players in cancer biology due to their roles in SUMOylation, transcriptional regulation, and modulation of signal transduction pathways. This study provides a comprehensive analysis of PIAS family genes from a pan-cancer viewpoint.</p><p><strong>Methodology: </strong>Detailed in silico analyses using publicly available databases and in vitro analyses involving cell culture, gene knockdown, colony formation, and wound healing assays.</p><p><strong>Results: </strong>Expression analysis revealed consistent up-regulation of PIAS1, PIAS2, PIAS3, and PIAS4 genes in tumors compared to normal tissues. Univariate Cox regression analyses indicate that high PIAS gene expression correlates with worse overall survival in specific cancers, particularly kidney renal papillary cell carcinoma (KIRP) and liver hepatocellular carcinoma (LIHC). Kaplan-Meier plots further confirm that higher PIAS gene expression is significantly associated with reduced survival probabilities in these cancers. Genetic alteration analysis showed low mutation frequencies in PIAS genes, suggesting their role in cancer progression is likely due to expression regulation rather than genetic mutations. Correlations with immune subtypes, the tumor microenvironment (TME), and immune stimulatory genes highlight the differential expression of PIAS genes across immune landscapes in KIRP and LIHC. Gene enrichment analysis emphasizes the involvement of PIAS genes in crucial cellular processes, including SUMOylation and ubiquitin-mediated proteolysis. Finally, knockdown experiments in HCC-LM3 cells demonstrate that PIAS2 and PIAS3 promote tumor growth and metastasis, reinforcing their potential as therapeutic targets.</p><p><strong>Conclusion: </strong>This study revealed the multifaceted roles of PIAS genes in KIRP and LIHC biology and their potential as prognostic biomarkers and therapeutic targets.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6346-6364"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoledronic acid improves periodontal health, reduces serum inflammation, and enhances bone metabolism in postmenopausal osteoporosis complicated by periodontitis.","authors":"Ge Xu, Ying Guo, Wei Wang, Wan-Qiu Yu, Qian-Min Chen, Hong Wang","doi":"10.62347/GXEB5902","DOIUrl":"10.62347/GXEB5902","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of zoledronic acid (ZA) on periodontal indices, serum inflammatory markers, and bone metabolism in postmenopausal osteoporosis (PMO) patients with periodontitis (PD).</p><p><strong>Methods: </strong>A total of 113 PMO+PD cases were recruited between May 2021 and February 2024. Fifty-two cases in the control group received standard therapy, while 61 cases in the observation group were treated with ZA. Therapeutic efficacy, periodontal indices (attachment loss [AL], probing depth [PD], and gingival bleeding index [GBI]), serum inflammatory markers (interleukin-1β [IL-1β], tumor necrosis factor-α [TNF-α], and C-reactive protein [CRP]), bone metabolism markers (N-terminal midfragment of osteocalcin [N-MID], beta-CrossLaps [β-CTx], and human calcitonin [hCT]), safety (fever, constipation, muscle soreness), and bone mineral density (BMD) at the lumbar spine and proximal femur were analyzed. A multivariable binary logistic regression model was used to determine factors influencing therapeutic efficacy.</p><p><strong>Results: </strong>The observation group demonstrated significantly better therapeutic outcomes than the control group. Treatment type was identified as an independent factor influencing efficacy. In the observation group, AL, PD, GBI, IL-1β, TNF-α, CRP, N-MID, and β-CTX levels were significantly reduced post-intervention compared to pre-intervention levels and the control group (all P<0.05), with no significant inter-group differences in hCT levels or adverse event rates (both P>0.05). BMD in the lumbar spine and proximal femur improved significantly in the observation group compared to the control group (both P<0.05).</p><p><strong>Conclusions: </strong>ZA positively impacts periodontal health, reduces serum inflammation, and enhances bone metabolism in PMO patients with PD.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6519-6527"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative recurrence prediction model for atrial fibrillation: a meta-analysis.","authors":"Chaofeng Chen, Yanyan Guo","doi":"10.62347/IJEP7120","DOIUrl":"https://doi.org/10.62347/IJEP7120","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate a recurrence risk prediction model for patients with Atrial Fibrillation (AF) following ablation, and to provide a reference for the model establishment and optimization.</p><p><strong>Methods: </strong>Literature retrieval was conducted in databases including PubMed, Cochrane Library, EMbase, and Web of Science to collect studies on recurrence risk prediction models for AF patients following ablation. Study quality was assessed using Prediction Model Risk of Bias Assessment Tool, and a meta-analysis was performed using MedCalc statistical software.</p><p><strong>Results: </strong>A total of 17 studies were included, with 4 of high risk of bias, 9 of unknown risk of bias, and 4 of low risk of bias. Across all studies, forest plots and logistic regression models were the most used prediction models. The area under the receiver operating characteristic curve (AUC) values of the prediction models ranged from 0.667 to 0.920, with a median AUC of 0.852. Through the calculation of the weighted summary of the AUC, the meta-analysis yielded a total AUC of 0.815 (0.780-0.850), indicating that the prediction models have good overall discrimination for the risk of recurrence in AF patients after ablation. After excluding studies with extreme AUC values, the adjusted AUC was 0.817 (0.786-0.849), suggesting that these extreme values did not significantly affect the overall combined results. Further subgroup analysis revealed that factors such as study design, follow-up time, sample size, and data set partitioning may significantly influence model performance and heterogeneity. Meta-analysis of predictive factors referenced in at least three studies showed that gender (<i>OR</i> = 0.862), atrial fibrillation type (<i>OR</i> = 0.660), and left atrial diameter (<i>OR</i> = 0.094) were predictive factors for postoperative recurrence in atrial fibrillation patients (<i>P</i> < 0.05). Results of Egger's test and Begg's test did not find evidence of publication bias in the studies.</p><p><strong>Conclusion: </strong>Current predictive models can be used as clinical decision support tools, but due to certain heterogeneity and risk of bias, they are recommended to be used cautiously in clinical practice and combined with other clinical information for comprehensive judgments.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6208-6224"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-lymphocyte ratio combined with albumin to globulin ratio for predicting rheumatoid arthritis-associated pneumonia.","authors":"Ruifeng Duan, Lei Lin, Yuxia Zou, Xiaoyu Lin","doi":"10.62347/JPNV8527","DOIUrl":"10.62347/JPNV8527","url":null,"abstract":"<p><strong>Objective: </strong>Rheumatoid arthritis-associated pneumonia (RAP) is a common complication of rheumatoid arthritis (RA) and is related to poor prognosis. Inflammation plays an important role in the development of RAP. This study aims to analyze and explore the predictive value of the neutrophil/lymphocyte ratio (NLR) combined with the albumin to globulin ratio (AGR) for assessing RAP.</p><p><strong>Methods: </strong>Data for this study were collected retrospectively from the database of Xuancheng People's Hospital between February 2021 and November 2023. Patients with RAP were assigned to the observation group (n=78), while patients with rheumatoid arthritis (RA) alone were assigned to the control group (n=75). The differences in general clinical data, NLR, and AGR were compared between the two groups. Risk factors for RAP were analyzed using univariate and multivariate Logistic regression.</p><p><strong>Results: </strong>The observation group had significantly lower AGR levels and higher NLR levels compared to the control group (all P<0.05). Univariate and multivariate logistic regression analyses identified age (95% CI 1.265-3.468; P=0.007), glucocorticoid use (95% CI 1.187-3.187; P=0.009), usage of disease-modifying anti-rheumatic drugs (DMARDs) (95% CI 1.257-2.997; P=0.006), AGR (95% CI 1.147-3.578; P=0.012), NLR (95% CI 1.198-2.978; P=0.008) and course of disease (95% CI 11.178-2.971; P=0.005) as independent prognostic factors for RAP. In addition, the ROC curve analysis showed that joint detection of NLR and AGR had a sensitivity of 98.8% and specificity of 81.8% for predicting RAP.</p><p><strong>Conclusion: </strong>NLR and AGR play significant roles in the occurrence and progression of RAP and can serve as predictive factors for early detection of RAP.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6796-6803"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral malleolus-first fixation improves short-term recovery in patients with trimalleolar fractures.","authors":"Fengfeng Zhang, Yulong Huo, Pengfei Jiang","doi":"10.62347/VQYO9186","DOIUrl":"10.62347/VQYO9186","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of different surgical fixation sequences on ankle joint stability and functional recovery in patients with trimalleolar fractures.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical records of 144 patients with trimalleolar fractures treated at Xi'an International Medical Center Hospital. Among these, 78 patients underwent the fixation sequence of lateral malleolus-posterior malleolus-medial malleolus (Group A), while 66 patients underwent the sequence of posterior malleolus-lateral malleolus-medial malleolus (Group B). Perioperative parameters, including operation time, intraoperative blood loss, healing time, hospital stay, and treatment cost, were compared between the two groups. Patient recovery was assessed using the Radiographic Union Score for Hip (RUSH) and Visual Analogue Scale (VAS) at postoperative 3 months and Biard-Jackson scores at postoperative 3 and 12 months. Logistic regression analysis was used to identify risk factors influencing postoperative joint function recovery. The incidence of postoperative complications was also compared between the two groups.</p><p><strong>Results: </strong>Group A demonstrated significantly shorter operation time (P < 0.001) and reduced intraoperative blood loss (P < 0.001) compared to Group B. No significant differences were observed in healing time (P = 0.905), hospital stay (P = 0.374), or treatment cost (P = 0.454) between the two groups. Similarly, RUSH (P = 0.780) and VAS (P = 0.590) scores at post-operative 3 months showed no significant differences between the two groups. However, Group A exhibited significantly higher Biard-Jackson scores at postoperative 3 months compared to Group B (P < 0.001), with no significant difference noted at postoperative 12 months (P = 0.157). The overall incidence of complications did not differ significantly between the groups (P = 0.164). Independent risk factors for prognosis included the treatment plan (P = 0.025), body mass index (P = 0.042), distal tibiofibular injury (P = 0.002), and intraoperative blood loss (P = 0.021).</p><p><strong>Conclusion: </strong>Patients with trimalleolar fractures who underwent fixation in the sequence of lateral malleolus-posterior malleolus-medial malleolus showed improved ankle joint functional recovery at postoperative 3 months compared to those treated with the posterior malleolus-lateral malleolus-medial malleolus sequence. No significant differences were observed at postoperative 12 months. Operation time and intraoperative blood loss were critical factors influencing short-term recovery outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6604-6614"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of body mass index on breast cancer prognosis: a focus on ER/PR status and subtype-specific recurrence risk.","authors":"Qinyan Shen, Liangying Zhao, Minjun Lu","doi":"10.62347/WJIQ1560","DOIUrl":"10.62347/WJIQ1560","url":null,"abstract":"<p><strong>Objective: </strong>To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.</p><p><strong>Methods: </strong>A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.</p><p><strong>Results: </strong>Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.</p><p><strong>Conclusions: </strong>Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for patients with ER-positive/PR-positive tumors.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6467-6476"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}