American journal of translational research最新文献

{"title":"Concurrent chemoradiotherapy plus immunotherapy for locally advanced non-small-cell lung cancer: clinical efficacy and prognostic analysis.","authors":"Xiangning Lan, Xuge Zhou, Kejun Dai, Qiang Wang","doi":"10.62347/EAAF2821","DOIUrl":"https://doi.org/10.62347/EAAF2821","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of concurrent chemoradiotherapy (CCRT) combined with immunotherapy (IT) for locally advanced non-small-cell lung cancer (LA-NSCLC). Short-term treatment outcomes during the two-year follow-up were recorded, and 2-year survival data were collected to analyze prognosis and identify factors affecting short-term outcome. Additionally, a predictive model was developed.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 90 LA-NSCLC patients admitted between February 2018 and February 2020. Patients were grouped according to their treatment regimens: 45 patients treated with 4-6 cycles of CCRT followed by 1 year of Sintilimab therapy were assigned to the observation group, and 45 patients treated with cisplatin/carboplatin + albumin-bound paclitaxel for 4-6 cycles after CCRT were assigned to the control group. Short-term adverse reactions were recorded for both groups. Patients were followed up after 4-6 cycles of IT or chemotherapy, and short-term efficacy and toxicity were evaluated. During the 2-year follow-up, overall survival (OS) and progression-free survival (PFS) were recorded, and survival curves were plotted. The Cox proportional hazards model was used to identify factors influencing PFS in the observation group, and a predictive model was developed. The predictive value of relevant indicators for prognosis was assessed using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The observation group showed superior short-term efficacy, with higher objective response rates (ORR) and disease control rates (DCR) compared to the control group (both P < 0.05). Regarding toxicity, the control group exhibited more severe adverse effects, particularly grade III and higher gastrointestinal reactions, leukopenia, thrombocytopenia, and anemia (all P < 0.05). The PFS was significantly higher in the observation group than that of the control group (P < 0.05). Additionally, the incidence of pneumonia was higher in the observation group, but it demonstrated better 2-year OS (P < 0.05). Cox multivariate analysis revealed that factors influencing PFS in the observation group included distant metastasis, tumor differentiation, platelet-to-lymphocyte ratio (PLR), and prealbumin (PAB). ROC analysis showed that the areas under the curve (AUC) for predicting prognosis based on PLR and PAB were 0.662 and 0.774, respectively, and the combined AUC of these indicators was 0.812.</p><p><strong>Conclusions: </strong>CCRT combined with IT is an effective treatment for LA-NSCLC, improving survival outcomes. The predictive model developed may help assess prognosis and guide early clinical intervention. Attention should be given to pneumonia prevention and management during IT. Moreover, the combination of PLR and PAB enhances prognostic prediction for NSCLC patients undergoing CCRT plus IT.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1311-1320"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety of photodynamic therapy combined with tea polyphenols in treating peri-implantitis.","authors":"Quan Yuan, Li-Li Zhao, Bao-Lian Shen, Qian Wang","doi":"10.62347/HMQB5921","DOIUrl":"https://doi.org/10.62347/HMQB5921","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy and safety of photodynamic therapy (PDT) plus tea polyphenols (TP) in treating peri-implantitis.</p><p><strong>Methods: </strong>The clinical records of 91 peri-implantitis patients treated at the North China University of Science and Technology Affiliated Hospital and Tangshan Hongci Hospital were analyzed retrospectively. Forty-one patients who received PDT alone were assigned to the control group, while the other 50 patients receiving both PDT and TP were allocated to the study group. Periodontal indices, inflammatory factors, swallowing function, pain, MOS 36-Item Short-Form Health Survey (SF-36) scores, therapeutic effect and adverse reactions were compared between the two groups.</p><p><strong>Results: </strong>Post therapy, significant reductions in the modified plaque index (mPLI), modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL) were observed in both groups (P<0.05), with more notable decreases in the study group (P<0.05). Besides, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) as well as interleukin-1β (IL-1β) also decreased notably in both groups (P<0.05), with notably lower levels in the study group (P<0.05). SF-36 scores across all dimensions significantly improved in both groups (P<0.05), with the study group demonstrating more substantial improvements (P<0.05). Swallowing function scores significantly decreased in both groups (P<0.05), with a more marked improvement in the study group (P<0.05). Similarly, the VAS scores of both groups significantly decreased post-treatment (P<0.05), especially the study group (P<0.05). In contrast to the control group, a notably higher overall response rate was observed in the study group (P=0.020), while no significant inter-group difference was observed in the total incidence of adverse reactions (P=0.683).</p><p><strong>Conclusion: </strong>PDT plus TP is more effective than PDT alone in treating peri-implantitis. This combined approach significantly reduces inflammation, improves periodontal health, and enhances quality of life, without increasing the incidence of adverse reactions. These findings suggest its potential for broader clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1029-1038"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intermittent oro-esophageal tube feeding combined with continuous nursing intervention on patients with intracerebral hemorrhage after surgery.","authors":"Naihui Yang, Dingfen Wu, Jian Zhou, Yiping Yin, Qing Guo, Xiaoli Feng, Hong Qi","doi":"10.62347/OJVV8646","DOIUrl":"https://doi.org/10.62347/OJVV8646","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the impact of intermittent oro-esophageal tube feeding combined with continuous nursing intervention on postoperative recovery in patients with intracerebral hemorrhage.</p><p><strong>Methods: </strong>A retrospective study was conducted on 212 patients with intracerebral hemorrhage after surgery who were admitted to the Third People's Hospital of Yibin from January 2022 to December 2023. Patients were divided into two groups: the control group (108 patients), who received intermittent oro-esophageal tube feeding, and the observation group (104 patients), who received intermittent oro-esophageal tube feeding combined with continuous nursing intervention. Clinical data, National Institutes of Health Stroke Scale (NIHSS), Glasgow Coma Scale (GCS), and the Activity of Daily Living (ADL) scores, psychological status, nutritional indices (albumin, hemoglobin, transferrin), compliance, and nursing satisfaction were compared between the groups.</p><p><strong>Results: </strong>Post-intervention, the observation group had significantly lower NIHSS scores and higher GCS, hemoglobin, albumin, transferrin, and ADL scores compared to the control group (all P < 0.05). Additionally, ESCA scores in the observation group were significantly higher than those in the control group (P < 0.05). Nursing satisfaction in the observation group was 97.12%, compared to 83.3% in the control group (P = 0.033).</p><p><strong>Conclusion: </strong>Intermittent oro-esophageal tube feeding combined with continuous nursing intervention improves neurological deficits, reduces brain injury, and promotes recovery of motor function and daily living abilities in patients with intracerebral hemorrhage after surgery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1065-1075"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of proton pump inhibitor (lansoprazole) on adverse drug reactions and rational drug use in elderly patients with chronic heart failure.","authors":"Lei Zhou, Su-Qing Kuang, Yuan Lv, Wen-Min Yu, Xiao-Bing Wei, Song Lin","doi":"10.62347/BZED8420","DOIUrl":"https://doi.org/10.62347/BZED8420","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and rationale of proton pump inhibitors (PPIs) for adverse drug reactions in elderly patients with heart failure (HF).</p><p><strong>Methods: </strong>From February 2019 to September 2021, 120 elderly patients with chronic heart failure (CHF) treated at Jintan First People's Hospital were enrolled as subjects. The patients were classified into a control group (n=60) and a research group (n=60). In addition to clopidogrel, the control group received cimetidine, while the research group received lansoprazole. Clinical efficacy, oxidative stress markers, echocardiographic indices, vascular endothelial function, cardiac function indicators, and adverse reactions were compared between the two groups. A cost-effectiveness analysis was also performed, and risk factors affecting patient efficacy were examined.</p><p><strong>Results: </strong>The clinical efficacy of the research group was remarkably superior to that of the control group (88.33% versus 63.33%, P<0.05). The combination of clopidogrel and cimetidine was identified as a risk factor affecting patient efficacy (P=0.003). Besides, the research group showed significant elevation in superoxide dismutase (SOD), glutathione peroxidase (GPx), left ventricular ejection fraction (LVEF), and nitric oxide (NO) after treatment, all higher compared to the control group (all P<0.05). Additionally, significant reductions in malondialdehyde (MDA), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic dimension (LVSD), endothelin-1 (ET-1), N-terminal pro-B-type natriuretic peptide (NT-proBNP), creatine kinase (CK), lactate dehydrogenase (LDH), and free fatty acids (FFA) were observed in the research group, all lower than the control group (P<0.05). The incidence of bradycardia, hypotension and electrolyte disturbances in the research group was remarkably lower (P<0.05). Additionally, the research group demonstrated greater cost-effectiveness compared to the control group.</p><p><strong>Conclusion: </strong>The use of PPIs in elderly patients with HF not only improves efficacy but also enhances safety, making this drug treatment approach worth promoting.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1290-1301"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive pan-cancer analysis of LAMA3: implications for prognosis and immunotherapy.","authors":"Hui Huang, Wei Dong, Xuan Qin, Ali Usama, Anees Cheema, Chunlei Deng, Sara Sarfaraz, Qingyun Pan, Majid Alhomrani, Abdulhakeem S Alamri, Naif ALSuhaymi, Saleh A Alghamdi, Ahmad A Alghamdi, Su Zheng","doi":"10.62347/QYJW2277","DOIUrl":"https://doi.org/10.62347/QYJW2277","url":null,"abstract":"<p><strong>Objectives: </strong>Laminin subunit alpha 3 (LAMA3) has been implicated in various cellular processes relevant to cancer progression, including cell proliferation, migration, and adhesion. In this study, we explored the expression, prognostic significance, and functional role of LAMA3 across multiple cancer types.</p><p><strong>Methodology: </strong>The in silico analyses involve using various bioinformatics tools and databases, such as The Cancer Genome Atlas (TCGA), TIMER2.0, GEPIA2, UALCAN, Kaplan-Meier (KM) plotter, GENT2, Human Protein Atlas (HPA), OncoDB, Gene Set Cancer Analysis (GSCA), and TISIDB. The in vitro analyses include cell culture, gene knockdown, and assays for cell proliferation, colony formation, and wound healing.</p><p><strong>Results: </strong>Pan-cancer analysis revealed significant variations in LAMA3 expression, with upregulation observed in cancers such as pancreatic adenocarcinoma (PAAD) and stomach adenocarcinoma (STAD), and downregulation in breast cancer (BRCA) and colon adenocarcinoma (COAD). Prognostic analyses indicated high LAMA3 expression correlated with poor overall survival (OS) in PAAD and STAD, whereas low expression was associated with adverse outcomes in BRCA. Validation analysis confirmed differential expression and localized LAMA3 primarily to the endoplasmic reticulum. Analysis of clinical features in BRCA, PAAD, and STAD showed consistent expression trends across different stages, races, and age groups. Additionally, mutational and copy number variations (CNVs) analyses revealed prevalent heterozygous amplifications and deletions in LAMA3 across BRCA, PAAD, and STAD. Promoter methylation was inversely correlated with LAMA3 expression in BRCA, PAAD, and STAD, although survival outcomes were unaffected. Protein-protein interaction (PPI) and gene enrichment analyses indicated LAMA3's involvement in ECM-receptor interactions and PI3K-Akt signaling, pathways critical in cancer. Finally, functional assays following LAMA3 knockdown in HT-29 cells demonstrated reduced cell proliferation, colony formation, and wound healing, implicating LAMA3 in tumor growth and metastasis.</p><p><strong>Conclusion: </strong>Overall, these findings suggest that LAMA3 plays a multifaceted role in tumorigenesis and holds potential as a prognostic biomarker and therapeutic target in multiple cancers.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1200-1222"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of uterine artery embolization through a distal radial artery approach for treatment of uterine fibroids.","authors":"Haoqiang Chao, Qiang Xu, Tao Shen, Yuanfeng Xu, Yu Zhou, Jie Xie, Zicong Xia, Caoye Wang, Qian Song","doi":"10.62347/XDKF7084","DOIUrl":"https://doi.org/10.62347/XDKF7084","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Uterine fibroids are common benign tumors of the female reproductive system, primarily affecting women of childbearing age. These tumors worsen patients' quality of life and fertility. Current treatment options for symptomatic uterine fibroids include drug therapy, surgical intervention, and interventional procedures. Among these, uterine artery embolization (UAE) has emerged as an effective interventional treatment. Recently, the transradial approach (TRA) and the distal transradial artery approach (dTRA) have gained attention as alternative access routes for UAE. This study aims to compare the clinical efficacy of TRA and dTRA in UAE for the treatment of uterine fibroids, providing insight to guide clinical decision-making.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective, multi-center analysis was conducted involving 300 patients with uterine fibroids who underwent UAE between July 2021 and June 2024. Patients were divided into two groups based on the vascular access approach: the control group (n = 144, UAE via TRA) and the experimental group (n = 156, UAE via dTRA). Data on general patient characteristics, ovarian function indicators, perioperative data, postoperative visual analogue scale (VAS) pain scores, and complication rates were collected and analyzed. Multivariate logistic regression was used to identify factors associated with dTRA puncture failure, and a nomogram risk prediction model was constructed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The baseline characteristics of the two groups were comparable, with no significant differences in general information (P &gt; 0.05). Also, no significant differences were observed in ovarian function indicators before and after surgery between the two groups (P &gt; 0.05). However, the control group exhibited significantly shorter puncture and operation times compared to the experimental group (P &lt; 0.05). The number of puncture attempts during the procedure was also lower, and the puncture success rate was higher in the control group (P &lt; 0.05). Postoperative pain, as measured by the VAS score, was consistently lower in the experimental group at all time points (P &lt; 0.05). The incidence of complications such as hypertonic hematoma of the right hand and forearm, radial artery spasm, and radial artery occlusion was significantly higher in the control group than in the experimental group (P &lt; 0.05). Factors influencing dTRA puncture failure included vessel puncture inner diameter, radial artery tortuosity, and previous puncture history (P &lt; 0.05), with vessel puncture inner diameter identified as the key determinant. A nomogram predictive model we constructed demonstrated strong reliability and is expected to assist in predicting puncture failure risk in clinical practice (P &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Although the dTRA approach showed a lower puncture success rate compared to TRA, it demonstrated clear advantages in reducing postoperative complications and pain, ","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1277-1289"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Guanxin Danshen dropping pills for the treatment of angina pectoris: a meta-analysis.","authors":"Lifei Yu, Shiwen Lu, Menghua Chen","doi":"10.62347/NWAZ5584","DOIUrl":"https://doi.org/10.62347/NWAZ5584","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of Guanxin Danshen dropping pills (GDDP) for treating angina pectoris (AP) in patients with coronary heart disease (CHD).</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) evaluating GDDP for AP in CHD patients were systematically screened from PubMed, Cochrane Library, Web of Science, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and WanFang databases from database inception to March 2023. Bias assessment followed the Cochrane Manual 5.1 criteira, and data analysis was performed using RevMan 5.3.</p><p><strong>Results: </strong>Twenty articles were included in the meta-analysis. Compared to standard therapy, GDDP exhibited a superior efficacy in treating AP (P < 0.01), significantly improved electrocardiogram (ECG) outcomes in AP patients (P < 0.00001), reduced frequency of AP episodes (P < 0.01), lowered incidence of cardiovascular events in AP patients (P = 0.01) and significantly elevated hypersensitive C-reactive protein (hs-CRP) and interleukin-18 (IL-18) levels (all P < 0.01). However, it did not significantly affect the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), or matrix metalloproteinase-9 (MMP-9) (all P > 0.05). GDDP also reduced total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels (all P < 0.01) as well as whole blood viscosity (WBV), plasma viscosity, fibrinogen and hematocrit levels (all P < 0.01). Additionally, the combination of GDDP and conventional CHD treatment was found to be safe.</p><p><strong>Conclusion: </strong>Combining GDDP with conventional western medicine was more effective than either treatment alone in reducing cardiovascular events, alleviating angina symptoms, improving inflammation, and optimizing hemorheological parameters, without increasing side effects. These findings underscore GDDP's use as a complementary treatment for CHD.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"708-721"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of 3D CE-MRA combined with ultrasound microbubble angiography for the diagnosis of lower extremity atherosclerotic occlusion.","authors":"Junzhi Sang, Chunyu Zhang, Luting Lv, Ying Wang, Tianren Zhao, Xuena E","doi":"10.62347/HVBK1487","DOIUrl":"https://doi.org/10.62347/HVBK1487","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the diagnostic performance of 3D contrast-enhanced magnetic resonance angiography (3D CE-MRA) and ultrasound microbubble angiography, individually and combined, using digital subtraction angiography (DSA) as the gold standard.</p><p><strong>Methods: </strong>This retrospective study included 60 patients diagnosed with lower extremity arterial stenosis occlusion (LEASO) from October 2019 to July 2022. All patients underwent 3D CE-MRA and ultrasound microbubble angiography, collectively assessing 470 arterial segments. The diagnostic accuracy, sensitivity, and specificity of 3D CE-MRA, ultrasound microbubble angiography, and their combination were evaluated compared to DSA findings. Kappa statistics were used to analyze the consistency of combined diagnostic efficacy.</p><p><strong>Results: </strong>The cohort included subjects aged 56 to 85 years, with a mean age of 65.42 ± 12.65 years. The diagnostic accuracy of 3D CE-MRA was 91.70%, with sensitivity and specificity of 99.72% and 65.49%, respectively. Ultrasound microbubble angiography revealed an 87.66% accuracy with sensitivity and specificity of 99.13% and 56.35%, respectively. When combined, the diagnostic accuracy was improved to 96.17%, maintaining a sensitivity of 100%, although specificity decreased to 50.44%. The Youden index improved to 96.17%, and the Kappa value of 0.951 indicated excellent agreement, demonstrating superior performance over individual modalities.</p><p><strong>Conclusion: </strong>The combination of 3D CE-MRA and ultrasound microbubble angiography exhibits enhanced diagnostic precision for detecting and grading LEASO compared to either modality alone. Despite reduced specificity, the combined approach increases overall diagnostic efficacy, advocating its potential for more comprehensive clinical evaluations. Further studies are warranted to confirm these findings and assess their clinical implications.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"818-831"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic neutropenia: a case report and literature review.","authors":"Jun-Li Li, Jing-Jing Zhao, Rui-Jun Li, Lei Zhao, Yan Ma, Jian-Ping Liu, Yu-Min Wang","doi":"10.62347/OLFS3168","DOIUrl":"https://doi.org/10.62347/OLFS3168","url":null,"abstract":"<p><p>To enhance the understanding of cyclic neutropenia (CyN) and improve the diagnosis and treatment of related diseases. Clinical data were analyzed from a 19-month-old child with recurrent infections and oral ulcers who was admitted to Inner Mongolia Maternal and Child Health Hospital on August 27, 2021 and a literature review was conducted. The patient developed an infection every 14-47 days, with fever, oral ulcers, bacterial infections, and decreased blood neutrophil counts at disease onset. There was no obvious abnormality in the bone marrow morphology, and genetic testing revealed heterozygous mutations in Neutrophil elastase (ELANE), leading to the diagnosis of CyN. For patients with periodic changes in clinical manifestations accompanied by granulocyte deficiency, bone marrow puncture and genetic testing of genes related to granulocyte deficiency should be performed. In patients with neutropenia, genetic testing can aid in the diagnosis of CyN.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1153-1161"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for urological infection after laparoscopic ureterolithotomy.","authors":"Xiaoliang Yuan, Hanping Wei, Xiaowu Liu, Zhimin Jiao, Tingchun Wu, Honglei Shi","doi":"10.62347/HNMG5196","DOIUrl":"https://doi.org/10.62347/HNMG5196","url":null,"abstract":"<p><strong>Objective: </strong>To investigate and analyze the risk factors of urological infection after laparoscopic ureterolithotomy.</p><p><strong>Methods: </strong>In this retrospective study, 312 patients who underwent laparoscopic ureterolithotomy were included. Among them, 164 patients developed urological infection post-surgery. Key risk factors for urological infection were identified using univariate and multivariate regression analyses. A clinical nomogram was constructed based on these factors, and its predictive accuracy was assessed using the concordance index (C-index) and calibration plot.</p><p><strong>Results: </strong>Univariate and multivariate regression analyses identified age >75 years old (95% CI 0.007-0.340; P=0.002), operation time ≥60 min (95% CI 4.506-90.528; P<0.001), postoperative catheter indwelling time >7 days (95% CI 2.315-6.060; P<0.001), diabetes mellitus (95% CI 4.051-24.682; P<0.001), and hospital stay >7 days (95% CI 1.600-37.144; P=0.011) as independent risk factors for urological infection after laparoscopic ureterolithotomy. Those factors were used to construct a predictive nomogram. The regression model was established as: logit (P) = -6.820 + 0.216 * age + 0.312 * operation time + 0.661 * postoperative indwelling catheter time + 0.433 * diabetes mellitus + 0.671 * hospital stay. The calibration curve demonstrated excellent accuracy of the nomogram model. Decision curve analysis indicated that the model is clinically applicable for threshold probabilities ranging from 20% to 75%.</p><p><strong>Conclusions: </strong>Age >75 years old, operation time ≥60 min, postoperative indwelling catheter time >7 days, diabetes mellitus, and hospital stay >7 days are independent risk factors for urological infection after laparoscopic ureterolithotomy. Effective monitoring, management, and predictive measures for high-risk patients should significantly reduce the incidence of urological infection.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1448-1458"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}