American journal of translational research最新文献

{"title":"Effects of inhalation anesthesia with sevoflurane combined with oxygen inhalation on cerebral oxygen metabolism and cognitive function in lung cancer patients undergoing unilateral lung ventilation.","authors":"Min Chen, Siren Shi, Jianyong Zhao, Qin Pan, Honghong Du, Quanwei Shen, Zhaohui Liu","doi":"10.62347/RHQW9053","DOIUrl":"10.62347/RHQW9053","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the effects of sevoflurane inhalation anesthesia on cerebral oxygenation and neurocognitive function during one-lung ventilation for lung cancer surgery.</p><p><strong>Methods: </strong>This retrospective study included 109 patients with lung cancer who underwent unilateral lung ventilation. Patients were divided into a propofol group (n=54) and a sevoflurane group (n=55) according to the anesthesia protocol. Hemodynamic parameters, cerebral oxygen metabolism, anesthesia recovery times, cognitive function, and pulmonary function were assessed.</p><p><strong>Results: </strong>Compared with the propofol group, the sevoflurane group had significantly lower heart rate (HR) and mean arterial pressure (MAP) at 15 minutes before surgery and immediately after surgery (<i>P</i> < 0.05). Regarding cerebral oxygenation, the sevoflurane group had significantly higher jugular venous oxygen saturation (SjvO₂) and regional oxygen saturation (rSO₂) than the propofol group at T1, T2, and T3 (<i>P</i> < 0.05). Analysis of cerebral oxygen metabolism indicators showed that, from T2, the sevoflurane group exhibited significantly higher Da-jvO₂ levels and lower CERO₂ values (<i>P</i> < 0.05) compared with the control group. No significant differences in hemoglobin concentration were observed between the two groups at any time point (<i>P</i> > 0.05). Recovery times for orientation, eye opening, and spontaneous breathing were shorter in the sevoflurane group (<i>P</i> < 0.05). MMSE scores were lower at 24 h postoperatively (<i>P</i> < 0.05), whereas all pulmonary function parameters were improved (<i>P</i> < 0.05). The proportion of postoperative POCD was higher in the sevoflurane group compared with that in the propofol group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Sevoflurane inhalation anesthesia can improve cerebral oxygen metabolism, accelerate the post-anesthesia recovery process, and enhance pulmonary function in patients undergoing one-lung ventilation for lung cancer surgery compared with propofol, but it is also associated with a higher risk of postoperative cognitive dysfunction at 24 hours after surgery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6627-6639"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous blood purification technology for treatment of critically ill patients with chronic renal failure.","authors":"Qing Shao, Xufeng Mei, Xueping Sun","doi":"10.62347/QLHV1991","DOIUrl":"10.62347/QLHV1991","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of continuous blood purification (CBP) on the treatment outcomes in critically ill patients with chronic renal failure (CRF).</p><p><strong>Methods: </strong>This single-center retrospective cohort study included 184 critically ill patients with CRF. According to treatment regimen, patients were allocated into a control group (n = 89; receiving conventional therapy) and an observation group (n = 95; receiving CBP plus conventional therapy). According to patient prognosis, they were categorized into a renal function recovery group (n = 62) and a non-recovery group (n = 122). Treatment outcomes were compared between the two groups, and factors influencing prognosis were analyzed.</p><p><strong>Results: </strong>After treatment, compared with the control group, the observation group showed significant improvements in heart rate (HR), respiratory rate (RR), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), N-terminal pro-brain natriuretic peptide (NT-proBNP), blood urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), partial pressure of oxygen (PO₂), bicarbonate (HCO₃ ^-), partial pressure of carbon dioxide (PCO₂), and quality of life scores (all <i>P</i> < 0.05). No significant difference in complication rates was observed between the two groups (<i>P</i> > 0.05). Multivariate logistic regression analysis identified hypertension, low albumin (ALB), low total protein (TP), elevated Scr, and high BUN as independent risk factors for poor renal function recovery, with Scr showing the strongest correlation.</p><p><strong>Conclusion: </strong>CBP may serve as an adjunctive therapy in critically ill patients with CRF, particularly in those with elevated BUN and inflammatory markers. However, its potential association with nutritional risks should be carefully considered.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6823-6833"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined core stability and nutritional therapy are associated with greater functional and nutritional gains in children with spastic cerebral palsy.","authors":"Wenying Guo, Silin Yan, Lihong Tian","doi":"10.62347/KPDC5791","DOIUrl":"10.62347/KPDC5791","url":null,"abstract":"<p><strong>Objective: </strong>To compare 12-month functional and nutritional outcomes among children with spastic cerebral palsy receiving conventional rehabilitation, rehabilitation plus individualized nutrition, or rehabilitation plus nutrition and core stability training.</p><p><strong>Methods: </strong>This single-center retrospective cohort included 60 children aged 3-12 years with Gross Motor Function Classification System levels I-IV (20 per group). Core training was delivered three times weekly for 30 minutes during a 3-month supervised phase, and nutrition followed an individualized five-step protocol. Outcomes were assessed at baseline and 3, 6, and 12 months. Continuous outcomes were analyzed by repeated-measures and time-specific analysis of variance with Holm-adjusted comparisons. Ordinal outcomes were analyzed non-parametrically.</p><p><strong>Results: </strong>Age and sex were comparable at baseline. Group-by-time interactions were observed for Gross Motor Function Measure-88 Dimension D (P=0.026), Dimension E (P=0.048), Berg Balance Scale (P<0.01), weight-for-age z-score (P<0.001), and body mass index-for-age z-score (P<0.01). At 12 months, the combined group exceeded the conventional group in Dimension D by 14.11 points (95% CI 6.50-21.72; Holm P=0.002), Dimension E by 13.54 points (95% CI 6.39-20.69; Holm P<0.001), and balance by 11.29 points (95% CI 5.02-17.56; Holm P=0.002). Weight-for-age and body mass index-for-age z-scores were higher by 2.35 and 1.99 units (both Holm P<0.001). Spasticity was lower and strength was higher in the combined group. No serious intervention-related adverse events were documented.</p><p><strong>Conclusions: </strong>Comprehensive rehabilitation was associated with larger functional and nutritional gains, but causality could not be established. A stratified randomized trial with blinded assessment and quantified adherence is warranted.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6916-6927"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel histone deacetylase 6 gene variant is associated with fetal hydrocephalus and lateral ventriculomegaly.","authors":"Xuliang Zhao, Qiang Ji, Xu Li, Feng Chen, Ying Jiang, Ruixia Tian","doi":"10.62347/EDSC1143","DOIUrl":"10.62347/EDSC1143","url":null,"abstract":"<p><strong>Objectives: </strong>Congenital hydrocephalus (CH) is a neurological disease that significantly impacts fetal nervous system development and subsequent quality of life. CH pathogenesis may be linked to genetic factors such as defects in the histone deacetylase 6 (<i>HDAC6</i>) gene. However, only one CH family has been reported to date, limiting our comprehension of the relationship between <i>HDAC6</i> and CH. Here, we investigated a family with an HDAC6-related fetal case of CH and ventriculomegaly, and propose a potential pathogenic mechanism involving the <i>HDAC6</i> gene in CH development.</p><p><strong>Methods: </strong>Skin tissue from a fetal-induced abortion as well as peripheral blood samples from both parents were collected for analysis. Whole-exome and Sanger sequencing were used to analyze fetal germline variants, and variant plasmids were constructed for western blot (WB) experiments; cycloheximide (CHX) chase assays with or without MG132 were further performed to assess protein degradation kinetics.</p><p><strong>Results: </strong>In the fetal tissue, a variant of the <i>HDAC6</i> gene was identified (NM_006044.4: c.206_c.209delTGGG, p.Val69fsTer7) that had not yet been documented in public databases. Both parents had wild-type versions of the <i>HDAC6</i> gene. WB analysis revealed a significantly lower expression level of the mutant HDAC6 protein compared to that of the wild-type protein in vitro, suggesting that the truncated protein may have reduced structural stability that leads to degradation. CHX chase assays further showed that the mutant protein had a shorter half-life (~14 h) than wild-type (~35 h) and that MG132 blocked its degradation, indicating proteasome-dependent degradation.</p><p><strong>Conclusions: </strong>The frameshift variant in the <i>HDAC6</i> gene likely contributed to the development of CH and ventriculomegaly in the fetus. This study underscores the importance of prenatal ultrasound for detecting early signs of CH and ventriculomegaly, and of molecular genetic diagnostic technologies to facilitate timely clinical intervention.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6682-6690"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total intravenous anesthesia facilitates early cognitive recovery compared with inhalational anesthesia in Alzheimer's disease patients after cervical lymphatic-venous anastomosis: a randomized controlled trial.","authors":"Kebing Dong, Junhui Lang, Jiafeng Fu, Jiandong Lan, Fan Xu, Tintin Cheng, Tao Jin, Hongfa Wang, Xiaomin Wu, Foquan Luo","doi":"10.62347/PZNZ6295","DOIUrl":"10.62347/PZNZ6295","url":null,"abstract":"<p><strong>Background: </strong>The optimal anesthesia method for Alzheimer's disease (AD) patients undergoing cervical lymphatic-venous anastomosis remains unclear. This study compared the effects of three general anesthesia techniques on postoperative cognitive outcomes in AD patients.</p><p><strong>Methods: </strong>In this prospective randomized controlled trial, 132 AD patients were assigned (1:1:1) to receive total intravenous anesthesia (TIVA), total inhalation anesthesia (IH), or combined intravenous-inhalation anesthesia (CI). The primary outcome was cognitive function assessed by MMSE, MoCA and CDR at postoperative day 7 (P7), P90 and P180. The secondary outcome was ADL scores at P180.</p><p><strong>Results: </strong>A total of 123 patients completed the study. At P7, MMSE scores in the TIVA group significantly improved from baseline (P < 0.05) and were superior to the IH and CI groups, which showed no significant change. At P90, MMSE scores improved in all three groups (P < 0.05), but returned to baseline by P180. No significant differences were observed in MoCA, CDR, or ADL scores at any time point.</p><p><strong>Conclusion: </strong>Among the three anesthesia methods, TIVA was associated with better early cognitive performance at P7 as measured by MMSE, compared with inhalational anesthesia. However, this benefit was not sustained to P180 and no significant changes were observed in MoCA or CDR scores at any time point. These findings suggest that TIVA may reduce early postoperative psychomotor disturbance rather than confer sustained neurocognitive recovery in this population.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7320-7330"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGTR1 inhibits pyroptosis and inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through the TGF-β pathway.","authors":"Jian Wang, Zongbiao Bai","doi":"10.62347/HTCE3264","DOIUrl":"10.62347/HTCE3264","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. The hyperactivation of fibroblast-like synoviocytes (FLS) is a major contributor to synovial hyperplasia and cartilage destruction, and FLS pyroptosis plays a pivotal role in RA pathogenesis. This study aimed to investigate the mechanisms by which AGTR1 regulates FLS pyroptosis and inflammatory cytokine secretion in RA to identify potential therapeutic targets for RA.</p><p><strong>Methods: </strong>Bioinformatic analysis assessed AGTR1 expression levels using the GSE21959 and GSE55235 datasets. qRT-PCR and western blot (WB) measured AGTR1 mRNA and protein levels in cell lines. Nigericin (a pyroptosis inducer), the TGF-β receptor I inhibitor SB505124, and the TGF-β neutralizing antibody 1D11 were administered to AGTR1-overexpressing RA-FLS, followed by western blot analysis of pyroptosis-related proteins. Flow cytometry, LDH assays, and propidium iodide staining evaluated pyroptosis levels. ELISA measured inflammatory cytokine secretion. WB confirmed TGF-β pathway activation.</p><p><strong>Results: </strong>AGTR1 was downregulated in RA-FLS. AGTR1 overexpression suppressed ASC, NLRP3, cleaved caspase-1, and GSDMD-N expression, thereby alleviating pyroptosis in RA-FLS (<i>P</i> < 0.05). AGTR1 overexpression inhibited secretion of inflammatory cytokines and reduced lactate dehydrogenase release (<i>P</i> < 0.05). We demonstrated that AGTR1-mediated repression of pyroptosis and inflammatory cytokine secretion in RA-FLS was dependent on the TGF-β signaling pathway.</p><p><strong>Conclusion: </strong>AGTR1 inhibits pyroptosis and attenuates inflammatory cytokine secretion in RA-FLS through TGF-β. These findings suggest that AGTR1 induction or TGF-β pathway activation may ameliorate RA pathology.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7463-7475"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined PDGF and ANGPTL4 in diabetic foot: diagnostic value and exploratory early changes after plantar arch angioplasty plus alprostadil.","authors":"Ping Sui, Ganchun Wu, Juan Wu, Shouguang Sui","doi":"10.62347/HMIF6269","DOIUrl":"10.62347/HMIF6269","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic value of combined platelet-derived growth factor (PDGF) and angiopoietin-like protein 4 (ANGPTL4) for distinguishing diabetic foot (DF) from diabetes mellitus (DM) without DF, and to explore their early changes following treatment initiation and their associations with 3-month ulcer healing.</p><p><strong>Methods: </strong>Clinical data were retrospectively collected from January 2024 to May 2025. Before propensity score matching (PSM), 153 patients with DF and 116 non-DF DM patients met the eligibility criteria; after 1:1 PSM, 97 patients were retained in each group. Serum PDGF and ANGPTL4 were measured at baseline in both groups, with additional measurements taken on day 5 after the initiation of plantar arch angioplasty (PAA) and alprostadil in the DF group. The primary analysis evaluated the diagnostic performance of the baseline biomarkers using receiver operating characteristic (ROC) curves, while secondary exploratory analyses assessed their day-5 changes and associations with 3-month ulcer healing.</p><p><strong>Results: </strong>At baseline, PDGF was 26.23% lower and ANGPTL4 was 32.22% higher in the DF group than in the matched DM group (both P<0.05). The combined baseline model yielded an area under the curve (AUC) of 0.805, surpassing the performance of either biomarker alone. Both biomarkers were also associated with ulcer size, Wagner grade, fasting plasma glucose, and hemoglobin A1c. On day 5 after PAA and alprostadil initiation, PDGF significantly increased and ANGPTL4 significantly decreased relative to baseline (both P<0.05). At 3 months, 66 of 97 patients achieved complete ulcer healing; the combined day-5 model discriminated healing status with an AUC of 0.764, a sensitivity of 59.09%, and a specificity of 87.10%.</p><p><strong>Conclusion: </strong>The combination of baseline PDGF and ANGPTL4 improved DF discrimination compared with either biomarker alone. Their day-5 changes and associations with 3-month ulcer healing were exploratory and should not be interpreted as evidence of treatment efficacy or validated prognostic utility.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7476-7486"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wogonoside alleviates ulcerative colitis-induced senescence by activating AMPK in <i>in vivo</i> and <i>in vitro</i> models.","authors":"Ning Luo, Yixia Wei, Zhaohui Tan, Jiaqi Fang, Xiaolu Chen","doi":"10.62347/NLXM4425","DOIUrl":"10.62347/NLXM4425","url":null,"abstract":"<p><p>Ulcerative colitis (UC), a chronic inflammatory bowel disease, causes extensive damage, primarily affecting the colonic mucosa, where persistent inflammation leads to conditions such as mucosal congestion. Recent studies suggest a reciprocal interaction between intestinal cell senescence and inflammation; however, the connection between senescence and UC remains underexplored. Wogonoside, a key active component of Huangqin Decoction, has unclear effects on intestinal cell and tissue senescence in the context of UC.</p><p><strong>Methods: </strong>Dextran Sodium Sulfate (DSS)-induced UC cell and animal models were employed to investigate the potential therapeutic effects of Wogonoside on intestinal epithelial cell senescence and its underlying mechanisms.</p><p><strong>Results: </strong>DSS treatment induced senescence in intestinal cells. Wogonoside alleviated senescence, as indicated by reduced levels of senescence markers (SA-β-gal, p16, p21, p53) and decreased epithelial damage, evidenced by increased occludin and ZO-1 expression. Mechanistic studies revealed that Wogonoside activates the AMPK signaling pathway, attenuating ROS production and thereby preventing intestinal cell senescence and injury. <i>In vivo</i>, Wogonoside similarly reduced DSS-induced senescence, as demonstrated by senescence marker analysis.</p><p><strong>Conclusion: </strong>This study demonstrates that Wogonoside mitigates UC-induced intestinal cell senescence and epithelial barrier disruption by activating the AMPK pathway and reducing ROS production, offering protective effects in both cellular and animal models. These findings suggest that Wogonoside may be a promising therapeutic strategy for the treatment of UC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7053-7074"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of treatment for acute hexavalent chromium poisoning in human renal proximal tubular epithelial cells with 2,3-dimercapto-1-propanesulfonic acid (DMPS).","authors":"I-Jeng Yeh, Hsin-Liang Liu, Chin-Shen Lin, Po-Min Chang, Ling-Yu Wu, Yi-Chun Tsai, Ya-Ling Hsu, Meng-Chi Yen","doi":"10.62347/TKBM7718","DOIUrl":"10.62347/TKBM7718","url":null,"abstract":"<p><strong>Objectives: </strong>Chelating agents have been utilized in clinical settings to counteract various heavy metal poisonings, although there are currently no established medical guidelines supporting the use of the chelating agent 2,3-dimercapto-1-propanesulfonic acid (DMPS) for treating acute hexavalent chromium (Cr(VI)) poisoning.</p><p><strong>Methods: </strong>Since systemic acute Cr(VI) poisoning has been associated with nephrotoxicity in clinical cases, this study utilized the immortalized human renal epithelial cell line HK-2 and primary proximal tubular epithelial cells (RPTEC) as <i>in vitro</i> models to explore potential treatments.</p><p><strong>Results: </strong>In the HK-2 cell model, cell viability dropped below 50% after exposure to 10 μmol/L Cr(VI) for 32 hours. Both simultaneous administration of 10 μmol/L Cr(VI) with 100 or 300 μg/mL DMPS and delayed treatment with DMPS after two hours effectively reduced Cr(VI)-induced cell death. Furthermore, in the RPTEC cell model, DMPS treatments ranging from 300 to 1000 μg/mL demonstrated significant protective effects on cell viability against Cr(VI) toxicity, mirroring the results observed in the HK-2 model. In contrast, meso-2,3-dimercaptosuccinic acid, another chelating agent, did not exhibit protective effects on HK-2 cells.</p><p><strong>Conclusions: </strong>These findings support DMPS as a promising antidote for acute Cr(VI) poisoning in kidney cells and provide valuable insights for potential clinical applications.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7177-7188"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of liposomal bupivacaine versus ropivacaine for fascia iliaca compartment block on postoperative pain and delirium in elderly patients undergoing hip arthroplasty.","authors":"Liping Cao, Jianwei Zhong, Yan Li, Jian Zhong","doi":"10.62347/LLXS3137","DOIUrl":"10.62347/LLXS3137","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of fascia iliaca compartment block (FICB) with liposomal bupivacaine versus ropivacaine on postoperative pain and delirium in elderly patients undergoing total hip arthroplasty (THA).</p><p><strong>Methods: </strong>Eighty-six elderly patients who underwent THA were retrospectively enrolled. They were divided into a liposomal bupivacaine group (LB group, n=43) and a ropivacaine group (R group, n=43) based on the medication administered. Perioperative hemodynamic parameters, inflammatory markers, postoperative pain intensity, incidence of delirium, analgesic use, postoperative recovery outcomes, and complication rates were compared between the groups.</p><p><strong>Results: </strong>The LB group had significantly lower Numerical Rating Scale scores than the R group both at rest and on movement at 12, 24, 48, and 72 hours postoperatively (P<0.05). The LB group had significantly lower inflammatory marker levels than the R group at 24 and 48 hours postoperatively. The LB group had a significantly lower incidence of postoperative delirium (POD) than the R group (4.65% vs. 18.60%, P<0.05). The LB group had fewer patient-controlled intravenous analgesia (PCIA) attempts, longer time to first PCIA, and lower sufentanil consumption postoperatively (P<0.05). The LB group had significantly shorter time to first ambulation and length of hospital stay compared with the LB group (P<0.05).</p><p><strong>Conclusion: </strong>FICB with liposomal bupivacaine may be associated with prolonged analgesia, a lower incidence of POD, faster recovery, and fewer complications in elderly patients undergoing THA.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6640-6650"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}