American journal of translational research最新文献

{"title":"Prognostic value of lipid variability for recurrence and mortality in elderly patients with acute ischemic cerebrovascular disease.","authors":"Changchun Zhu, Xiaole Pan, Ran Xie, Bin Liu","doi":"10.62347/RFBV1794","DOIUrl":"10.62347/RFBV1794","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between lipid variability and the risk of recurrence and mortality during the acute phase of ischemic cerebrovascular disease (ICD) in elderly patients.</p><p><strong>Methods: </strong>Clinical data, lipid profiles, and follow-up information were retrospectively collected from 149 elderly ICD patients who underwent at least three lipid measurements (non-baseline) at The Third People's Hospital of Hefei (The Third Clinical College of Anhui Medical University) from May 2021 to May 2024. Lipid indices included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). Variability was assessed using standard deviation (SD), coefficient of variation (CV), and variability independent of the mean (VIM). Follow-up concluded in May 2024. Patients were classified into no-recurrence, recurrence, and death groups. Logistic multivariate regression analysis was used to identify risk factors for recurrence and death. Receiver operating characteristic (ROC) curve analyses were applied to assess the predictive value of lipid variability.</p><p><strong>Results: </strong>Variabilities in LDL-C, HDL-C, TC, and TG were significantly higher in the recurrence and death groups compared to the no-recurrence group. Logistic regression analysis identified lipid variability indices as independent risk factors for recurrence and death. ROC analysis furtherdemonstrated their predictive value.</p><p><strong>Conclusion: </strong>Variabilities in LDL-C, HDL-C, TC, and TG are independent risk factors for recurrence and death in elderly ICD patients. Combined analysis of lipid variability enhances diagnostic accuracy and may improve the prognostic assessment in this population.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4651-4662"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for secondary epilepsy in children with viral encephalitis.","authors":"Yun Cheng, Rui Wang, Mingnong Xia, Fan Zhang, Wenbo Li, Feng Li, Wu Yang","doi":"10.62347/KOGU7794","DOIUrl":"10.62347/KOGU7794","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical manifestations of secondary epilepsy (EP) in children with viral encephalitis and to identify any associated risk factors.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 130 children with viral encephalitis treated at Lu'an People's Hospital Affiliated with Anhui Medical University between December 2021 and October 2024. Of these, 36 children who developed secondary EP were classified as the EP group, and 94 children without secondary EP were categorized as the non-EP group. The overall incidence of secondary EP, clinical symptoms, cerebrospinal fluid (CSF) indices, and electroencephalogram (EEG) findings were compared between the groups. Multivariate logistic regression analysis was employed to identify independent risk factors for the development of secondary EP.</p><p><strong>Results: </strong>Of the 130 children with viral encephalitis, 36 (27.69%) developed secondary EP. Among them, 10 children (27.78%) had self-limited generalized EP, and 26 children (72.22%) had self-limited focal EP. Status epilepticus occurred in 7/36 cases (19.44%), but not in the other 29/36 cases (80.56%). No notable differences were observed in fever, headache, drowsiness, and coma between the EP group and non-EP group (<i>P</i>>0.05). However, vomiting and coma were significantly more frequent in the EP group (<i>P</i><0.05). Abnormal EEG findings were also more prevalent in the EP group compared to the non-EP group (<i>P</i><0.05). Logistic regression analysis identified non-use of antiepileptic drugs (<i>P</i>=0.039; CI: 0.181-0.958), elevated white blood cell count in CSF (<i>P</i>=0.006; CI: 1.028-1.185), and moderate to severe abnormal EEG results (<i>P</i>=0.041; CI: 1.035-5.41) as independent risk factors for the occurrence of secondary EP in children with viral encephalitis.</p><p><strong>Conclusion: </strong>The incidence of secondary EP in children with viral encephalitis is relatively high. Non-use of antiepileptic drugs, elevated white blood cell count in the CSF, and moderate to severe abnormal EEG results were independent risk factors for the occurrence of secondary EP in children with viral encephalitis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4794-4803"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonography in granulomatous mastitis: diagnostic differentiation, treatment response, and prognostic value.","authors":"Xiaoli Feng, Honglei Zhang, Qiusheng Chang, Na Song, Qingju Li","doi":"10.62347/MMDY4883","DOIUrl":"10.62347/MMDY4883","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the diagnostic value of ultrasonography in distinguishing granulomatous mastitis (GM) from ductal carcinoma in situ (DCIS), and to assess its prognostic relevance in monitoring treatment response and predicting recurrence.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed conventional B-mode ultrasound and contrast-enhanced ultrasound (CEUS) features in 146 patients with histologically confirmed GM and 140 with DCIS. Key comparisons included: (1) B-mode characteristics (lesion morphology, posterior acoustic features, microcalcifications, vascular patterns, etc.); (2) CEUS quantitative parameters [mean transit time (mTTI), time to peak, rise time, etc.]. Clinical treatment responses and recurrence data were also collected for GM patients.</p><p><strong>Results: </strong>GM exhibited distinct ultrasound characteristics compared to DCIS, including more frequent posterior acoustic enhancement (58.90% vs. 12.14%), absence of microcalcifications (82.19% vs. 49.29%), and a higher prevalence of marginal or mixed vascular patterns (83.02% vs. 73.34%) (all P < 0.001). On CEUS, GM demonstrated shorter mTTI but higher peak enhancement, wash-in, and wash-out rates than DCIS (all P < 0.001). Among the GM cohort, 121 of 146 patients achieved clinical cure. These cured patients had significantly lower pretreatment mTTI values (P < 0.001), and mTTI demonstrated predictive value for treatment response (area under the ROC curve = 0.765; sensitivity: 68.0%, specificity: 86.0%). During one-year follow-up, 15 of the 121 cured patients experienced recurrence (12.40%). The presence of ductal dilatation on ultrasound was associated with a higher recurrence rate.</p><p><strong>Conclusion: </strong>Ultrasound, particularly when combined with CEUS parameters, not only facilitates the differentiation of GM from DCIS but also serves as a valuable tool for evaluating treatment response and predicting recurrence in GM patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4631-4641"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous thrombolysis combined with Tirofiban in the treatment of capsular warning syndrome: a case report.","authors":"Qingqing Wang, Huihui Wang, Hongjing Wang, Shaoying Wang, Dan Xing, Yizhe Meng","doi":"10.62347/KQTZ1379","DOIUrl":"10.62347/KQTZ1379","url":null,"abstract":"<p><p>Capsular warning syndrome (CWS) is a subtype of transient ischemic attack (TIA), accounting for 4.5% of all TIAs. Due to the absence of cortical signs within 24 hours of onset, CWS is often misdiagnosis or overlooked, making it a rare clinical syndrome with a high disability rate and an increased risk of progressing to cerebral infarction. Clinical practitioners need to pay close attention and provide proactive and effective treatment. Currently, there is no universally recognized treatment standard. This report presents the experience of treating a CWS patient at our hospital with venous thrombolysis combined with Tirofiban.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4524-4528"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of airway management method on hypothermia in patients undergoing laparoscopic gynecologic surgery: tracheal intubation, supreme laryngeal mask, and i-gel laryngeal mask.","authors":"Feng Qi, Danxu Zhang, Yuanyuan Meng, Fen Jiang, Zhihua Zhang","doi":"10.62347/YMWW9219","DOIUrl":"10.62347/YMWW9219","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the association between different airway management methods and perioperative hypothermia in gynecologic laparoscopic surgery.</p><p><strong>Methods: </strong>This single-center prospective cohort observational study included patients who underwent gynecologic laparoscopic surgery between September 2022 and February 2023. A total of 531 patients scheduled for non-emergent surgery were recruited and randomly assigned to the tracheal intubation group (T group) (n = 153), supreme laryngeal mask group (L group) (n = 156), or i-gel laryngeal mask group (i group) (n = 151). Following anesthesia induction, the primary outcome was the incidence of intraoperative hypothermia at the end of surgery. Secondary outcomes included final core body temperature, incidence of nosebleeds, flushing and fluid administration, urine output, and other relevant parameters. Multivariate logistic regression analyses were conducted to identify risk factors associated with hypothermia.</p><p><strong>Results: </strong>The incidence of postoperative hypothermia in the L and i groups was significantly lower than of the T group (P < 0.05). At the end of surgery, the core body temperature in the T group was also lower than in the L and i groups (P < 0.05). Extubation and recovery times differed significantly among the three groups, with the T group showing longer durations compared to the two laryngeal mask groups (P < 0.05). During postoperative follow-up, the incidence of nasal bleeding in the T group was higher than of the other two groups (P < 0.05). No significant differences were observed in the incidence of other postoperative complications (P > 0.05).</p><p><strong>Conclusion: </strong>In patients undergoing gynecologic laparoscopic surgery, tracheal intubation is associated with a higher likelihood of perioperative hypothermia compared to laryngeal mask use.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4470-4483"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of motor imagery training on joint function recovery following unicompartmental knee arthroplasty.","authors":"Songlin Chen, Yong Wang","doi":"10.62347/AZKM5743","DOIUrl":"10.62347/AZKM5743","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively investigate the effects of motor imagery (MI) training in enhancing knee joint function after unicompartmental knee arthroplasty (UKA).</p><p><strong>Methods: </strong>This study included 84 patients who underwent UKA at the Orthopedic Joint Department of Shangluo Central Hospital between January 2023 and October 2024. Patients were divided into an experimental group (n = 42) receiving MI training and a control group (n = 42) receiving standard rehabilitation. Clinical outcomes were assessed using the Oxford Knee Score (OKS), Visual Analogue Scale (VAS), range of motion (ROM), Timed Up and Go Test (TUGT), Berg Balance Scale (BBS), and Hospital for Special Surgery Knee Score (HSS) at 1, 6, and 12 months postoperatively. Imaging parameters were also analyzed at 6 months.</p><p><strong>Results: </strong>Compared to the control group, the experimental group exhibited significantly better clinical outcomes across all measured functions (OKS, VAS, ROM, TUGT, HSS, BBS, Knee flexion angle) at 1, 6, and 12 months postoperatively (all P < 0.01). Specifically, both groups showed significant OKS improvement and VAS reduction post-surgery. The experimental group had more pronounced OKS enhancement and VAS decrease than the control group, especially at 6 and 12 months (all P < 0.001). ROM, HSS, and BBS scores and knee flexion angle progressively increased over time in both groups (all P < 0.05), with the experimental group having higher values at all follow-up times (all P < 0.01). TUGT times were significantly reduced in both groups postoperatively, with greater reduction in the experimental group than the controls at each time point (P < 0.01).</p><p><strong>Conclusions: </strong>Motor imagery training, when combined with standard postoperative care, significantly enhances knee joint recovery following UKA, reduces patient discomfort, and accelerates functional rehabilitation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4506-4515"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of standardized nursing protocol on nursing quality and complications in pediatric patients with massive scalp hematoma undergoing negative pressure drainage.","authors":"Wei Song, Fei Di, Mingxing Wu, Qiaoying Li, Jie Jia","doi":"10.62347/TCZH5661","DOIUrl":"10.62347/TCZH5661","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of standardized nursing process intervention on care quality and complications in children with large scalp hematomas treated with modified negative-pressure drainage.</p><p><strong>Methods: </strong>This prospective randomized controlled study was conducted in the Children's Hospital Affiliated with the Capital Institute of Pediatrics. A total of 102 children with massive scalp hematoma were randomly assigned to a control group (n = 52, with conventional nursing care) and an observation group (n = 50, with standardized nursing care). Drainage time, hematoma subsidence time, and nursing-related outcomes were compared between the two groups. Hematologic data were assessed preoperatively, and at 24 h and 72 h postoperatively.</p><p><strong>Results: </strong>Compared to the control group, the observation group exhibited significantly shorter drainage time, hematoma resolution time, wound healing time, and hospitalization time (all <i>P</i><0.05), as well as lower hospitalization cost (<i>P</i><0.05). Rehabilitation outcomes were significantly improved across age groups (all <i>P</i><0.05), with lower pain scores (all <i>P</i><0.05), reduced complication and readmission rates (all <i>P</i><0.05), higher quality-of-care scores (all <i>P</i><0.05), and greater nursing satisfaction (<i>P</i><0.05). At 24 h after operation, the observation group had higher levels of hemoglobin (Hb) and fibrinogen (Fib) (<i>P</i><0.05), and lower levels of prothrombin time (PT), activated partial thromboplastin time (APTT), C-reactive protein (CRP), pro-calcitonin (PCT), and white blood cell count (WBC) (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Implementation of standardized nursing processes significantly improves care quality, reduces complications, and promotes faster recovery in pediatric patients undergoing modified negative-pressure drainage for large scalp hematoma, supporting its broad application in clinical practice.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4804-4817"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects of metformin versus sodium glucose transporter 2 inhibitors on cardiovascular outcomes in patients with type 2 diabetes.","authors":"Xiuxian Hao, Jing Cui, Meihua Zhang, Dong Zhang","doi":"10.62347/YNWL3428","DOIUrl":"10.62347/YNWL3428","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the long-term cardiovascular effects of Metformin and sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A retrospective study was conducted on 692 T2DM patients treated between January 2020 and January 2023. Patients were divided into two groups: SGLT2i group (n = 460) and Metformin group (n = 232) according to their treatment protocol. Data on demographics, blood glucose/lipid profiles, echocardiographic parameters, and cardiovascular outcomes were collected over a 2-year follow-up period. Outcomes included myocardial infarction (MI), stroke, mortality, and hospitalization for heart failure (HHF).</p><p><strong>Results: </strong>Both treatments significantly reduced blood glucose levels, with Metformin showing greater improvements in glycated hemoglobin (HbA1c). SGLT2i demonstrated superior reductions in triglycerides and total cholesterol levels. Echocardiography revealed enhanced diastolic function with SGLT2i. Moreover, SGLT2i significantly reduced MI and HHF risk, though safety profiles were similar except for higher genital infection incidence in the SGLT2i group.</p><p><strong>Conclusions: </strong>While Metformin remains effective for glycemic control, SGLT2i offers distinct cardiovascular benefits, notably in reducing the risks of MI and HHF.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4267-4277"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological markers, pulmonary function, and prognosis in pediatric asthma: predictive model development and validation.","authors":"Lifang Liu, Youyou Feng","doi":"10.62347/OPRX1666","DOIUrl":"10.62347/OPRX1666","url":null,"abstract":"<p><strong>Background: </strong>Pediatric asthma is a chronic and heterogeneous respiratory disease that poses considerable challenges in predicting exacerbations and long-term outcomes. This study aimed to enhance prognostic prediction for pediatric asthma by integrating serological markers with pulmonary function parameters.</p><p><strong>Methods: </strong>A retrospective analysis was conducted involving 318 pediatric asthma patients from one hospital, with external validation performed on an additional cohort of 283 patients from another institution. Serological markers, including white blood cell (WBC) count, eosinophil percentage, interleukins, 14-3-3β protein, and total immunoglobulin E (IgE), were measured alongside pulmonary function indicators such as forced expiratory volume in one second (FEV1) and the FEV1/forced vital capacity (FVC) ratio. Statistical analyses included correlation testing, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis to develop and validate the prognostic model.</p><p><strong>Results: </strong>Elevated WBC count, eosinophil percentage, 14-3-3β protein, and total IgE levels were significantly associated with poorer prognosis. Among interleukin profiles, increased interleukin-4 (IL-4) and interleukin-7 (IL-7) levels, along with reduced interleukin-10 (IL-10), were linked to unfavorable outcomes. In contrast, higher FEV1 and FVC values correlated with better outcomes. The integrated predictive model demonstrated strong predictive performance, with an area under the curve (AUC) of 0.818 in the modeling cohort and 0.874 in the validation cohort.</p><p><strong>Conclusion: </strong>The integration of serological biomarkers and pulmonary function indices provides a robust framework for predicting prognosis in pediatric asthma, supporting the development of individualized management strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4198-4212"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis on the diagnostic value of Syndecan 2 methylation in stool for the detection of colorectal cancer.","authors":"Zhenhai Jing, Nixia Yang, Tailin Li, Yuyao Du, Meihui Fu, Qibin Song, Qing Hong","doi":"10.62347/LBQG7510","DOIUrl":"10.62347/LBQG7510","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, and early detection is essential for improving patient survival rates. Stool-based DNA methylation indicators are among the molecular biomarkers that have shown great promise as CRC screening methods. Because of its aberrant methylation patterns in malignant cells, the gene Syndecan 2 (SDC2), which is important in cellular development and differentiation, has shown potential as a biomarker for CRC. The goal of this study is to conduct a meta-analysis to evaluate the diagnostic utility of SDC2 methylation in stool samples for the detection of colorectal cancer. The study involved a comprehensive literature search to identify all relevant studies on SDC2 methylation for CRC analysis from the beginning until 2023. Relevant studies were identified through systematic searches in Google Scholar, Web of Science, PubMed, and Scopus. STATA program and Meta Disc 1.4 were used to perform the meta-analysis. A total of 30 studies, encompassing 120 CRC cases and controls, were included. The analysis revealed the pooled sensitivity and specificity of SDC2 methylation in stool samples, as demonstrated by the area under the curve (AUC). SDC2 methylation demonstrated strong diagnostic accuracy, with significantly higher sensitivity in patients with advanced-stage CRC. SDC2 methylation offers a convenient, non-invasive diagnostic option and represents a useful biomarker for CRC screening. Even though it demonstrates a high degree of diagnostic accuracy, more research is necessary to improve test procedures and confirm outcomes across a variety of categories.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4421-4432"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}