American journal of translational research最新文献

{"title":"Effect of blood purification combined with antibiotics on CC-16 and SP-D levels and prognosis in patients with severe acute pancreatitis complicated by acute respiratory distress syndrome.","authors":"Jing Guo, Bin Wu, Yuee Liu, Biao Zhu, Furong Lu","doi":"10.62347/LVRO1003","DOIUrl":"10.62347/LVRO1003","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of continuous blood purification (CBP) combined with antibiotics on pulmonary surfactant protein D (SP-D), Clara cell protein-16 (CC-16), and prognosis in patients with severe acute pancreatitis (SAP) complicated by acute respiratory distress syndrome (ARDS).</p><p><strong>Methods: </strong>A total of 128 patients with SAP and ARDS treated at Fudan University Shanghai Cancer Center from June 2021 to June 2023 were enrolled. Patients were divided into two groups: a control group (n=64) receiving routine treatment (gastrointestinal decompression, somatostatin administration, nutritional support, correction of water-electrolyte imbalance, and microcirculation improvement) and an observation group (n=64) treated with CBP combined with antibiotics. Clinical data, including the pancreatic edema resolution time, ventilator weaning time, and hospital stay, were compared between groups. Additional comparisons included intra-abdominal pressure (IAP), blood amylase (AMS), urinary amylase (UAMY), inflammatory markers [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β)], respiratory mechanics indices [airway peak pressure (Peak), airway plateau pressure (Plat), respiratory rate (F)], and blood oxygen levels [partial pressure of arterial oxygen (PaO₂), PaO₂/fraction of inspired oxygen (FiO₂)] before and after treatment.</p><p><strong>Results: </strong>The observation group demonstrated significantly better outcomes compared to the control group in terms of pancreatic edema resolution time, ventilator weaning time, hospital stay, and other indicators (all P<0.05). The 28-day mortality rate in the observation group was significantly lower than in the control group (P<0.05). Post-treatment levels of CC-16, SP-D, Peak, Plat, and other indicators improved significantly in both groups compared to baseline (all P<0.05). The observation group exhibited significantly greater improvements in PaO₂ and PaO₂/FiO₂ compared to the control group (all P<0.05).</p><p><strong>Conclusion: </strong>CBP combined with antibiotics significantly improves clinical symptoms, reduces inflammatory markers, enhances prognosis, and lowers mortality rates in patients with SAP complicated by ARDS.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"429-439"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular mechanism underlying angiogenesis in a mouse model of chronic kidney disease after ischemic stroke.","authors":"Fang Wang, Liangxiang Lu, Jialun Feng, Jinhua Zheng, Zefeng Wei, Ziqiang Wang","doi":"10.62347/ZTSX4782","DOIUrl":"10.62347/ZTSX4782","url":null,"abstract":"<p><strong>Objectives: </strong>The study aims to establish a reliable chronic kidney disease (CKD) mouse model by examining the effects of an adenine-containing diet on renal function and pathology. It also explores the impact of CKD on motor function and infarct volume following cerebral infarction and investigates the role of calcium in modulating the AMPK/SIRT1/HIF1-α signaling pathways.</p><p><strong>Method: </strong>The CKD mouse model was induced through an adenine-enriched diet. Renal function impairment was assessed by analyzing blood samples for creatinine and blood urea nitrogen levels at 0 and 6 weeks. Pathologic changes in renal tissue were examined. The study also evaluated motor function, infarct volume, survival rates, body weight changes, and functional assessments. Additionally, cerebral cortex angiogenesis was assessed in the context of ischemic stroke.</p><p><strong>Result: </strong>The CKD mouse model showed significant renal tissue alterations, including luminal dilation, glomerular hypertrophy, fibrosis, and inflammatory infiltration. There was a notable reduction in angiogenic markers in the CKD group compared to controls. The study also found increased cerebral calcium levels and altered expression of AMPK, SIRT1, HIF1-α, and VEGF in the CKD group.</p><p><strong>Conclusions: </strong>The research successfully created the CKD mouse model and emphasized the disease's many effects, including its influence on neurological disorders. The results provide an understanding of the molecular processes behind changes brought on by CKD and may have consequences for angiogenesis and signaling pathway-focused therapeutic approaches.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"528-537"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small cell lung cancer and prostate cancer cells with varying neuroendocrine differentiation markers show sensitivity to imipridone ONC201/TIC10.","authors":"Elizabeth Ding, Maximillian Pinho-Schwermann, Shengliang Zhang, Connor Purcell, Wafik S El-Deiry","doi":"10.62347/IBUS3598","DOIUrl":"10.62347/IBUS3598","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether neuroendocrine differentiation (NED) markers, activation of the integrated stress response (ISR), and TRAIL pathway alter neuroendocrine tumor (NET) cell death and ONC201 sensitivity.</p><p><strong>Methods: </strong>We conducted cell viability assays to determine ONC201 sensitivity. Western blot analysis was performed to evaluate NED, ISR, and TRAIL pathway markers. Expression levels of NED markers were compared between cell lines with and without BRN2 overexpression.</p><p><strong>Results: </strong>Prostate cancer (PCa) and small cell lung cancer (SCLC) cell lines (N = 6) were sensitive to ONC201. Endogenous NET marker levels varied across PCa and SCLC cells. Transient BRN2 overexpression slightly reduced some NET markers while maintaining the sensitivity of PCa cells to ONC201.</p><p><strong>Conclusions: </strong>PCa cell lines exhibit sensitivity to ONC201, with variability of NED features. These findings are relevant to the design of future studies evaluating imipridone efficacy in PCa and suggest that non-NET patients could be included in such studies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"104-115"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body shape index: an index for early target organ damage in hypertension.","authors":"Wangjiang Wei, Ping Ding","doi":"10.62347/FMEB5040","DOIUrl":"10.62347/FMEB5040","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between obesity-related indices and target organ damage in hypertension, with the goal of improving damage prevention and treatment strategies.</p><p><strong>Methods: </strong>This retrospective study included 150 hypertension cases from January 2022 to December 2023 treated at Beijing Ditan Hospital, including 72 cases of isolated hypertension, 48 with hypertension complicated by kidney damage, 47 with hypertension and left ventricular hypertrophy, and 44 with hypertension and carotid atherosclerosis. Clinical indicators and obesity-related indices were collected to analyze their correlation with target organ damage in hypertension.</p><p><strong>Results: </strong>A Body Shape Index (ABSI) (OR: 1.003 [1.001-1.913], P=0.007), BMI (OR: 1.054 [1.005-1.694], P=0.023), and BRI (OR: 0.562 [0.287-0.934], P=0.034) were independently associated with hypertensive kidney damage. Age (OR: 1.037 [1.000-1.635], P=0.034), ABSI (OR: 0.901 [0.882-0.998], P=0.034), and blood pressure grading (OR: 1.473 [1.175-1.845], P=0.002) were independent risk factors for hypertensive left ventricular hypertrophy. ABSI (OR: 1.012 [1.001-1.623], P=0.032) and smoking history (OR: 0.892 [0.781-0.998], P=0.021) were independent risk factors for hypertensive carotid artery plaque formation.</p><p><strong>Conclusion: </strong>ABSI is an independent risk factor for target organ damage in hypertension.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"200-210"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Oxford Arthroplasty Early Recovery Score for patients undergoing Joint arthroplasty.","authors":"Ying Pu, Lu Zhang, Rui Zhang, Sha Luo, Keqin Hu","doi":"10.62347/YMBI7245","DOIUrl":"10.62347/YMBI7245","url":null,"abstract":"<p><strong>Objective: </strong>To translate and adapt the Oxford Arthroplasty Early Recovery Score into Chinese, creating an assessment tool suitable for the early postoperative recovery of patients undergoing Joint arthroplasty.</p><p><strong>Methods: </strong>By adopting the convenience sampling method, 200 patients who had undergone hip arthroplasty at The Affiliated Hospital of North Sichuan Medical College between February 2022 and February 2023, with a two-week follow-up, were selected as the research subjects. Clinical and disease-related data were collected, and a preliminarily analysis was conducted to identify factors influencing early postoperative recovery.</p><p><strong>Results: </strong>A total of 200 questionnaires were distributed, and all were retrieved, with no invalid questionnaires excluded, resulting in an effective response rate of 100%. The total score of the early postoperative recovery quality of patients averaged (-2.49±12.32) points, the average score of pain sensation was (0.86±5.16) points, the average physical function was (-3.72±4.07) points, and the average psychosocial status was (-2.00±5.02) points. Statistical analysis showed that gender (P=0.004), age (P<0.0001), per capita monthly household income (P<0.0001), course of disease (P<0.0001), and BMI (P=0.006) had a significant effect on early postoperative recovery.</p><p><strong>Conclusion: </strong>The Chinese version of the OARS scale has good reliability and validity, making it a useful tool for assessing limb function recovery and physical symptom perception in the early postoperative stage for patients undergoing joint arthroplasty.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"338-348"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of dipyridamole plus IVIG and aspirin on anti-platelet aggregation factors and inflammatory factors in children with Kawasaki disease.","authors":"Lijiang Du, Quan Gan, Wei Ma, Chuanfu Qiao, Yunjiao Luo","doi":"10.62347/XIDS4307","DOIUrl":"10.62347/XIDS4307","url":null,"abstract":"<p><strong>Background: </strong>While standard therapeutic regimens for Kawasaki disease (KD) in children have exhibited some efficacy, they remain far from ideal. Thus, the pursuit of alternative or improved treatment modalities remis clinically critical.</p><p><strong>Objective: </strong>This study primarily aimed to assess the effect of dipyridamole (DIP) plus human intravenous immunoglobulin (IVIG) and aspirin (ASP) as to efficacy, antiplatelet aggregation factors, and inflammatory markers in children with KD.</p><p><strong>Methods: </strong>A total of 95 pediatric KD patients were selected from February 2021 to July 2024, with 44 cases in the control group treated with IVIG + ASP and 51 cases in the research group given DIP in addition to IVIG + ASP. The efficacy, symptom resolution time (defervescence, limb swelling, mucosal congestion, and cervical lymphadenopathy), coronary artery injury, coagulation function (thrombin time [TT], prothrombin time [PT], and activated partial thromboplastin time [APTT]), antiplatelet aggregation factors (erythrocyte sedimentation rate [ESR], white blood cell count [WBC], and platelet count [PLT]), and inflammatory factors (C-reactive protein [CRP], and tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]) levels were compared between the two groups.</p><p><strong>Results: </strong>The research group exhibited a higher overall treatment efficacy rate, shorter symptom resolution times, and a significantly lower incidence of coronary artery injury compared to the control group. No significant differences were observed between the two groups or before and after treatment within the same group in coagulation function indices. Markedly reduced levels of anti-platelet aggregation factors and inflammatory markers were observed in the research group versus those in the control group.</p><p><strong>Conclusion: </strong>DIP in combination with IVIG and ASP significantly enhances treatment efficacy and improves levels of antiplatelet aggregation factors and inflammatory markers in children with KD.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"330-337"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of lipoprotein a and high-sensitivity CRP combined assay in diagnosing coronary heart disease and their relationship with coronary lesion severity.","authors":"Jinxia Li, Hui Sun, Rongrong He, Yuan Qu, Xuemei Yue","doi":"10.62347/CTSP7747","DOIUrl":"10.62347/CTSP7747","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic performance of lipoprotein A (LP(a)) and high-sensitivity C-reactive protein (hs-CRP) combined assay for coronary heart disease (CHD) and their association with the severity of coronary lesions.</p><p><strong>Methods: </strong>This retrospective study included 106 patients who underwent coronary angiography (CAG) due to thoracic distress at Xi'an International Medical Center Hospital from June 2020 to October 2021. The patients were categorized into two groups: the CHD group (n=67) and the non-CHD group (n=39). Subgroup analysis was performed within the CHD group based on the Gensini score. Serum levels of LP(a) and hs-CRP were compared between the groups and subgroups, and their correlations with the Gensini score were analyzed. The diagnostic performance of LP(a), hs-CRP, and their combined assay for detecting CHD was evaluated using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Serum levels of LP(a) and hs-CRP were significantly higher in the CHD group than those in the non-CHD group (P<0.001). Within the CHD subgroups, both LP(a) and hs-CRP levels were significantly elevated in the moderate and high Gensini score groups compared to the low Gensini score group (P<0.001). There was a positive correlation between LP(a) and hs-CRP levels with the Gensini score (r=0.288, P=0.003; r=0.276, P=0.004). The area under the ROC curve (AUC) for the combination of LP(a) and hs-CRP (0.924, 95% CI: 0.865-0.983) was significantly greater than that for LP(a) (0.858, 95% CI: 0.783-0.933) or hs-CRP (0.854, 95% CI: 0.772-0.936) alone (P<0.05).</p><p><strong>Conclusion: </strong>Elevated serum levels of LP(a) and hs-CRP are associated with CHD and correlate with the severity of coronary lesions. The LP(a) and hs-CRP combined assay improves the diagnostic performance for CHD, suggesting potential clinical value.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"645-651"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of physiological capacity and surgical stress scores for perioperative complications in radical resection for colorectal cancer: a propensity-matched analysis.","authors":"Yue Li, Beibei Wang, LongKit Tsang, Meng Zou, Linchong Yu, Shijun Xia, Wenjiang Wu","doi":"10.62347/JZKO9876","DOIUrl":"10.62347/JZKO9876","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the predictive value of physiological capacity and surgical stress scores for perioperative complications in radical resection for colorectal cancer (CRC).</p><p><strong>Methods: </strong>A retrospective case-control study was performed from October 2021 to October 2023 at a single center, involving patients scheduled for radical resection of CRC. Patients were divided into groups with and without perioperative complications, and a propensity score matching was performed to minimize potential bias from clinical confounding variables. General patient data, including demographic information, comorbidities, tumor characteristics, surgical parameters, postoperative recovery, and Estimation of Physiologic Ability and Surgical Stress (E-PASS) scores, were collected and analyzed.</p><p><strong>Results: </strong>After propensity score matching, factors such as age, diabetes, pulmonary disease, heart disease, and American Society of Anesthesiologists (ASA) grade remained significant predictors for complications (P < 0.05). Prolonged operation, increased blood loss, specific surgery types, and emergent surgeries were linked to a higher risk of perioperative complications (all P < 0.05). Patients with complications experienced longer postoperative hospital stays, increased adjuvant chemotherapy use, and lower quality of life scores (all P < 0.05). Perioperative risk score (PRS), surgical stress score (SSS), and composite risk score (CRS) were positively correlated with the incidence of perioperative complications (all P < 0.001). The AUC values for PRS, SSS, and CRS were 0.848, 0.854, and 0.882 respectively, indicating moderate to high predictive value for perioperative complications.</p><p><strong>Conclusion: </strong>Physiological capacity and surgical stress scores, age, comorbidities, surgical parameters, postoperative recovery, and the E-PASS scores emerged as key predictive factors for perioperative complications in radical resection for CRC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"254-266"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory mechanisms of m⁶A methylation in dilated cardiomyopathy.","authors":"Hao Zhang, Haiyang Guo, Fengjiao Han, Yang Zheng","doi":"10.62347/AOSK8903","DOIUrl":"10.62347/AOSK8903","url":null,"abstract":"<p><p>Dilated cardiomyopathy (DCM) is a complex heart condition marked by genetic mutations, myocardial dysfunction, and progressive heart failure. N6-methyladenosine (m⁶A) methylation, a key epigenetic modification, plays a crucial role in DCM by regulating gene expression in various pathologic processes, including cardiomyocyte death, inflammation, fibrosis, and mitochondrial dysfunction. m⁶A modifications influence cardiomyocyte survival by modulating apoptosis, necroptosis, ferroptosis, and autophagy-related genes, balancing cellular death and survival pathways. Additionally, m⁶A-driven regulation of inflammation and fibrosis contributes to immune microenvironment stability and extracellular matrix remodeling, affecting fibroblast activation and myocardial stiffness. Mitochondrial health, vital for cardiomyocyte energy demands, is also regulated by m⁶A methylation. Enzymes like methyltransferase-like (METTL) 3 and METTL14 promote mitophagy-related gene expression, while fat mass and obesity-associated protein modulates calcium homeostasis, mitigating oxidative stress and energy imbalances. Targeting m⁶A-related enzymes with small molecules, gene editing, or RNA interference (RNAi) offers potential for tailored DCM therapy. Emerging technologies, such as nanopore m⁶A-modified mRNA detection, reveal new insight into cardiomyocyte metabolism, suggesting novel therapeutic avenues. This review underscores m⁶A methylation as a pivotal epigenetic mechanism of DCM, providing a basis for advanced diagnosis and therapy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"47-59"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis on risk factors for cervical cancer in perimenopausal women.","authors":"Ling Gong, Qingqing Xiao, Xiaofang Xie, Qiong Zheng","doi":"10.62347/KOWP5000","DOIUrl":"10.62347/KOWP5000","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To analyze the risk factors for cervical cancer in perimenopausal women.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The data of 380 cervical cancer patients and 380 healthy individuals undergoing physical examinations at the Health Management Center of West China Hospital, Sichuan University, between April 2022 and March 2023, were retrospectively analyzed. The baseline information, genetic characteristics, medical records (both past and present), menstrual cycles, healthy conditions of the reproductive system, and sexual activities of patients in the cervical cancer patient group and healthy control group were compared. Logistic regression analysis was conducted to evaluate the potential risk factors and to comprehensively assess the impact of these factors on the prevention of cervical cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Participants in the healthy control group showed a significantly lower age for first intercourse, first marriage and first pregnancy compared to those in the cervical cancer patient group. The proportions of married participants and those with a high school degree or above were higher in the healthy control group than those in the cervical cancer patient group. Additionally, the proportion of participants without a history of genetic diseases or any other diseases was significantly higher in the healthy control group than that in the cervical cancer patient group (P&lt;0.05). The number of participants with regular menstrual cycles was significantly higher and the incidence of dysmenorrhea markedly lower in the healthy control group in comparison to the cervical cancer patient group (P&lt;0.05). Meanwhile, the number of participants with only one pregnancy experience was higher and those with an abortion history was lower in the healthy control group than those in the cervical cancer patient group (P&lt;0.05). Notably, more participants in the healthy control group preferred using contraception, underwent regular gynecological examinations and washed their external genitalia before sexual intercourse when compared to the cervical cancer patient group. Moreover, the healthy control group also had a higher proportion of participants who had sexual intercourses less than 4 times a week and who manually washed their underwear in comparison to the cervical cancer patient group (P&lt;0.05). In addition, a total of 11 risk factors were identified to be in association with cervical cancer, which were human papillomavirus (HPV) testing (OR = 30.326), presence of reproductive system symptoms (OR = 27.605), dysmenorrhea (OR = 26.470), washing external genitalia before intercourse (OR = 0.430), passive smoking (OR = 16.119), duration of heating in winter (OR = 0.444), physical exercises (OR = 0.272), consumption of fried foods (OR = 8.240), vegetable intake (OR = 0.933), alcohol consumption (OR = 5.468), and consumption of chili peppers (OR = 4.797), listed in the order of their influential power.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/st","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 1","pages":"211-220"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}