American journal of translational research最新文献

{"title":"Diagnostic value of NLR, PLR and SIRI in peritoneal dialysis-associated peritonitis.","authors":"Ye Liu, Ling Zhang, Tian Tian, Zhihui Guo, Yi Shao, Xiaoying Ma, Yuping Sheng, Fuyun Sun","doi":"10.62347/EQGN8207","DOIUrl":"https://doi.org/10.62347/EQGN8207","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SIRI) in peritoneal dialysis-associated peritonitis (PDAP).</p><p><strong>Methods: </strong>In this retrospective study, the clinical data from 130 patients who underwent peritoneal dialysis (PD) for the first time at the Cangzhou Central Hospital from January 2019 to January 2022 were rigorously reviewed and analyzed. Based on the occurrence of PDAP during treatment, patients were classified into the peritonitis group (n=31) and the non-peritonitis group (n=99). The expression levels and diagnostic value of NLR, PLR, and SIRI were analyzed in the contest of PDAP. Pearson correlation analysis was performed to examine the correlations between NLR, PLR and SIRI in PDAP patients, and the joint diagnostic value of NLR, PLR, and SIRI was evaluated. Additionally, risk factors associated with PDAP were identified.</p><p><strong>Results: </strong>Patients in the peritonitis group were older than those in the non-peritonitis group, and experienced longer duration of dialysis (P<0.05). The peritonitis group exhibited significantly higher NLR, PLR and SIRI levels than the non-peritonitis group (P<0.001). Pearson correlation analysis revealed significant positive corrections between NLR, PLR and SIRI in PDAP patients. Logistic regression analysis identified NLR, PLR, and SIRI as independent influencing factors for the occurrence of PDAP. ROC curve analysis revealed that the combined use of NLR, PLR, and SIRI for diagnosing PDAP yielded an AUC of 0.935, significantly higher than their individual predictions, along with superior diagnostic accuracy.</p><p><strong>Conclusion: </strong>NLR, PLR, and SIRI are independent risk factors for the occurrence of PDA. These indices hold significant diagnostic value for PDAP, and their combined utilization can enhance diagnostic accuracy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2250-2257"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for postpartum hemorrhage in critically ill pregnant women with placenta previa and construction of a dynamic nomogram model.","authors":"Xiaomeng Yang, Xuexue Che, Yao Li, Wenjing Liu, Jia Zhang, Jiao Han","doi":"10.62347/QKFG5933","DOIUrl":"https://doi.org/10.62347/QKFG5933","url":null,"abstract":"<p><strong>Objective: </strong>To identify independent risk factors for postpartum hemorrhage (PPH) and to develop a dynamic nomogram model for early prediction and prevention of PPH.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 372 pregnant women with placenta previa admitted to Baoji Maternal and Child Health Hospital between March 2022 and March 2024. Patients were categorized into a PPH group (blood loss ≥ 1500 mL, n = 109) and a non-PPH group (blood loss < 1500 mL, n = 263). Clinical data were collected from electronic medical records. The included cases were split into a training set (n = 260) and a validation set (n = 112) at a 7:3 ratio. Multivariate logistic regression were conducted to identify risk factors for PPH, and a nomogram predictive model was constructed based on the identified factors. The predictive performance of the model was assessed using ROC curve analysis, decision curve analysis (DCA), and calibration curves.</p><p><strong>Results: </strong>Multivariate logistic regression identified age ≥ 32.5 years (P < 0.001), number of cesarean sections ≥ 2 (P = 0.037), placental adhesion (P < 0.001), placental implantation (P = 0.002), partial placenta previa (P = 0.004), prior cesarean section with placenta previa (P = 0.020), and anemia (P = 0.002) as independent risk factors for PPH. The nomogram achieved an AUC of 0.880 in the training set and 0.840 in the validation set, indicating strong discrimination and predictive capability. ROC analysis showed that age, number of cesarean sections, and placental adhesion had high sensitivity and specificity for predicting PPH, supporting the model's clinical utility.</p><p><strong>Conclusion: </strong>The dynamic nomogram model developed in this study, based on factors such as age, number of cesarean sections, placental adhesion, placental implantation, placenta previa type, previous cesarean with placenta previa, and anemia, demonstrated excellent predictive performance for early identification of PPH risk.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1834-1847"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of rivastigmine and memantine combined for treatment of patients with Alzheimer's disease: a retrospective study.","authors":"Haiyan Wang, Pingping Lv","doi":"10.62347/YOPP4162","DOIUrl":"https://doi.org/10.62347/YOPP4162","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects and safety of combining rivastigmine hydrogen tartrate capsules with memantine tablets for Alzheimer's disease (AD).</p><p><strong>Methods: </strong>A retrospective study was conducted on AD patients admitted to The Third People's Hospital of Yongkang from November 2021 to June 2023. There were two groups: a single drug group (n=21) given only memantine tablets, and a combination group (n=39) treated with both rivastigmine hydrogen tartrate capsules and memantine tablets. Data were collected, including age, gender, education, overall response rate, adverse reaction rate, mini-mental state examination (MMSE), activity of daily living (ADL), behavioral pathology in Alzheimer's disease scale (BEHAVE-AD), serum tumor necrosis factor-α (TNF-α), serum interleukin-6 (IL-6) and serum Tau at baseline and at week 12.</p><p><strong>Results: </strong>In both groups, compared to baseline, at week 12, MMSE increased, while ADL, BEHAVE-AD, serum TNF-α, IL-6, and Tau decreased (all P<0.05). After treatment, compared with the single drug group at week 12, the combination group had a higher MMSE (t=2.519, P=0.015), better effectiveness (χ²=4.331, P=0.037), and lower ADL (t=2.418, P=0.019), BEHAVE-AD (t=3.231, P=0.002), TNF-α (t=3.496, P=0.001), IL-6 (t=2.513, P=0.015) and Tau (t=2.290, P=0.026) levels.</p><p><strong>Conclusion: </strong>The combination of the two drugs was more effective in alleviating AD symptoms with comparable safety. It also showed an edge in suppressing pro-inflammatory cytokines and Tau in AD.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2240-2249"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis and research progress of OTOF gene related auditory neuropathy: a retrospective review.","authors":"Jiang-Hui Yang, Duo-Mi Zhang, Kai Wang","doi":"10.62347/JDLC8070","DOIUrl":"https://doi.org/10.62347/JDLC8070","url":null,"abstract":"<p><p>Auditory Neuropathy (AN) is a disorder of auditory information processing caused by dysfunction in inner hair cells, synapses, spiral ganglion cells, and auditory nerves. Patients with AN typically have normal sound detection abilities but struggle with speech comprehension. Representing 10% of cases of permanent hearing loss in children, AN is a significant contributor to hereditary deafness. The otoferlin protein, encoded by the OTOF gene, is involved in the fusion of Ca²⁺-dependent synaptic vesicles in inner hair cells and neurotransmitter release. Mutations in the OTOF gene are a major cause of AN. Patients with OTOF mutations exhibit distinct cochlear microphonic waveforms compared to other AN patients and may experience temperature-sensitive AN. Although most individuals with OTOF mutations present with stable, congenital, or prelingual onset of severe to profound hearing loss, some show atypical clinical phenotypes. The genotype-phenotype correlation in OTOF-related AN is still not fully understood. This review aims to explore the pathogenic mechanisms and the latest research progress in otoferlin-related AN based on current findings.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1643-1650"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-implant anchorage in adolescent orthodontics: a promising and advantageous option.","authors":"Yi Xu, Kai Ying, Xianghua Lang, Caidong Xu","doi":"10.62347/MORQ8289","DOIUrl":"https://doi.org/10.62347/MORQ8289","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the influence of micro-implant anchorage (MIA) on the orthodontic efficacy, safety, and oral health of adolescents.</p><p><strong>Methods: </strong>A total of 113 adolescent orthodontic patients treated during January 2019 to January 2021 were selected for study. Among them, 55 received traditional orthodontic treatment (reference group) and 58 underwent MIA (research group). The efficacy, orthodontic effect (molar displacement, upper central incisor [UCI] inclination, and convex distance differences), safety (oral infection, soft tissue edema, loose teeth, discomfort), oral health status (oral health-related quality of life [OHRQOL]), oral micro-ecological environment (detection rate of oral pathogens), gingiva-related indices (plaque index [PLI], sulcus bleeding index [SBI], and gingival index [GI]), masticatory function (bite force, masticatory efficiency), and orthodontic satisfaction were compared between the two groups.</p><p><strong>Results: </strong>The total effective rate and OHRQOL score of the research group were markedly higher compared with the reference group. Additionally, the research group reported lower molar displacement, PLI, SBI, and GI, and higher UCI inclination, convex distance, bite force, masticatory efficiency, and orthodontic satisfaction. Besides, the overall adverse reaction rate and oral pathogen detection rate were statistically lower in the research group.</p><p><strong>Conclusion: </strong>MIA is highly effective in adolescent orthodontics, significantly improving oral health, the oral microecological environment, gingival condition, masticatory function, and orthodontic satisfaction. It offers better orthodontic outcomes and higher safety.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1882-1891"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the PDCA cyclic care model in improving lung function and speed of recovery in children with mycoplasma pneumonia.","authors":"Jing Chen, Luyi Pan, Yindan Qiu, Li Jin","doi":"10.62347/IXQM3048","DOIUrl":"https://doi.org/10.62347/IXQM3048","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of Plan-Do-Check-Act (PDCA) cycle nursing on the prognosis of children with mycoplasma pneumonia (MMP).</p><p><strong>Methods: </strong>Clinical data of 112 children with MMP who were admitted to Hangzhou Ninth People's Hospital from September 2020 to December 2022 were retrospectively analyzed. The children were divided into a control group (56 cases, receiving routine care) and a PDCA group (56 cases, receiving PDCA care) according to nursing interventions. Blood gas analysis, pulmonary function, inflammation levels, clinical treatment, complications, and satisfaction were compared between the two group pre- and post-care.</p><p><strong>Results: </strong>The results showed that the children in PDCA group experienced a more significant improvement in blood oxygen levels, evidenced by increased PaO₂ and SaO₂ levels and decreased PaCO₂ levels, as well as enhanced lung function. Meanwhile, PDCA care was more effective in reducing interleukin-6, C-reactive protein, and tumor necrosis factor-alpha levels in children. In addition, children in the PDCA group recovered more quickly, with shorter times to temperature normalization, cough improvement, asthma resolution, lung rales disappearance, and hospital stay. Moreover, PDCA nursing effectively reduced the incidence of intrapulmonary and extrapulmonary complications, and improved care quality and patient satisfaction.</p><p><strong>Conclusions: </strong>The PDCA cycle nursing model significantly improves the prognosis of children with MMP by promoting faster recovery, reducing adverse reactions, and enhancing overall nursing satisfaction. This approach fosters a more harmonious doctor-patient relationship, contributing to better patient outcomes and a more effective care environment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1792-1802"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testis-enriched <i>Socs7</i> is not essential for spermatogenesis and male fertility in mice.","authors":"Nianchao Zhou, Junpeng Deng, Hui Zhou, Haoyue Hu, Bing Jiang, Tiantian Wu, Cong Shen, Yibo Wu, Jianjun Xie","doi":"10.62347/VIVI6495","DOIUrl":"https://doi.org/10.62347/VIVI6495","url":null,"abstract":"<p><strong>Objectives: </strong>As a crucial member of the Suppressor of Cytokine Signaling (SOCS) family, SOCS7 regulates various physiological processes, including insulin resistance, inflammation, and tumor suppression. However, its role in male germ cells remains poorly understood. This study aims to investigate the function of SOCS7 in spermatogenesis and uncover its potential regulatory mechanisms.</p><p><strong>Methods: </strong>We conducted bioinformatics analyses to examine the expression profile of <i>Socs7</i> in the testes, generated <i>Socs7</i>-knockout (KO) mice using CRISPR/Cas9 genome editing, and assessed testicular morphology through histological and immunohistochemical staining. Semen quality was evaluated using computer-assisted sperm analysis (CASA), and testicular apoptosis was examined using the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay.</p><p><strong>Results: </strong>Bioinformatics analysis revealed high expression of <i>Socs7</i> in both human and mouse testes. However, <i>Socs7</i>-KO mice exhibited normal fertility, with no significant differences in testicular morphology, sperm quality, or spermatogenesis compared to wild-type (WT) mice. Additionally, testicular apoptosis in <i>Socs7</i>-KO mice was not significantly altered.</p><p><strong>Conclusions: </strong>Our study demonstrates that although <i>Socs7</i> is highly expressed in the testes, its deletion does not impair male fertility or spermatogenesis in mice. These findings provide valuable insights into the role of SOCS7 in male reproduction and help prevent unnecessary duplication of research efforts.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1780-1791"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacies of different surgical approaches in the treatment of hyperextension tibial plateau fractures.","authors":"Bo Zhang, Lixin Xu, Shiqin Gu, Yongfeng Yao","doi":"10.62347/TOIF6752","DOIUrl":"https://doi.org/10.62347/TOIF6752","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacies of an anteromedial combined with anterolateral approach versus posteromedial combined with anterolateral approach in the treatment of hyperextension tibial plateau fractures.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the data of 112 patients with hyperextension tibial plateau fractures treated in the Orthopedics Department of No. 215 Hospital of Shaanxi Nuclear Industry from January 2020 to December 2022. The patients were categorized as the control group (anteromedial combined with anterolateral approach, n=62) and the observation group (posteromedial combined with anterolateral approach, n=60) in accordance with the surgical approaches they underwent. Clinical outcomes, surgical time, time needed to be able to undertake weight-bearing activities, Visual Analogue Scale (VAS) pain scores, and the incidence of postoperative complications were compared between the two groups. Knee joint function was assessed using the Hospital for Special Surgery (HSS) knee scoring system. Changes in the posterior tibial slope and varus angles were evaluated using X-ray imaging.</p><p><strong>Results: </strong>All patients recovered from tibial plateau fractures after treatment, with their knee joint function returning to pre-injury status to a large degree. At 6 months postoperatively, there was no statistically significant difference in HSS knee scores between the two groups (P=0.775). However, at 12 months postoperatively, the HSS knee scores in the control group were significantly lower than those in the observation group (P < 0.001). Additionally, the rate of patients demonstrating excellent or good knee function was significantly lower in the control group than that in the observation group (P=0.041). In terms of pain evaluation, the VAS pain scores of patients were higher in the control group than those in the observation group on days 1 and 3 after surgery (P < 0.001), whereas no statistically significant difference was observed between the two groups on postoperative day 12 (P=0.337). At 6 months postoperatively, the posterior tibial slope angle was larger in the control group than that in the observation group (P < 0.01). The time needed to be able to undertake weight-bearing activities was markedly longer and the varus angle greater in the observation group than those in the control group on the day of surgery (P < 0.01). Lastly, there was no statistically significant difference in the incidence of complications between the two groups (P=0.045).</p><p><strong>Conclusion: </strong>The posteromedial combined with anterolateral approach for treating hyperextension tibial plateau fractures has presented ideal clinical outcomes, reduced patients' pain, and promoted the recovery of their joint function without increasing the incidence of adverse reactions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1718-1727"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the effects of microscopic vs. neuroendoscopic transsphenoidal surgery on visual and pituitary function and postoperative recurrence factors in patients with pituitary tumors.","authors":"Fada Dong, Fei Duan","doi":"10.62347/PUQA6181","DOIUrl":"https://doi.org/10.62347/PUQA6181","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of microscopic and neuroendoscopic transsphenoidal surgeries on visual function, pituitary function, and factors influencing postoperative recurrence in patients with pituitary tumors.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 164 patients with pituitary tumors who underwent surgery at The First People's Hospital of Xianyang from March 2020 to March 2022. Based on the surgical approach, patients were divided into an observation group (n=93) and a control group (n=71). The observation group underwent neuroendoscopic transsphenoidal pituitary tumor resection, while the control group underwent microscopic transsphenoidal pituitary tumor resection. General clinical data, perioperative indicators, hormone levels, quality of life, and olfactory function were compared between the two groups. Postoperative recurrence was recorded, and logistic regression analysis was performed to identify factors influencing postoperative recurrence in the patients.</p><p><strong>Results: </strong>The control group exhibited a greater amount of intraoperative bleeding and a longer postoperative hospital stay compared to the observation group (P<0.0001). The total tumor resection rate was significantly lower in the control group than that in the observation group (P=0.002). Additionally, the numbers of patients in the control group who experienced improvements in vision (P=0.013), headache (P=0.004), and sexual dysfunction (P=0.047) were lower than those in the observation group. One month after surgery, levels of prolactin, human growth hormone, adrenocorticotropic hormone, and thyroid-stimulating hormone were higher in the observation group than those in the control group. The quality of life score one month after surgery was higher in the observation group than that in the control group (P<0.0001). In addition, the olfactory function score one month after surgery was lower in the observation group compared to the control group (P<0.0001). The overall incidence of postoperative complications was higher in the control group (P=0.034). There was no statistically significant difference in recurrence rates between the two groups (P=0.102). Multivariate logistic regression analysis identified tumor size (P=0.001, OR=7.227), Knosp classification (P=0.005, OR=0.238), and Ki-67 index (P=0.001, OR=4.969) as independent risk factors for recurrence within two years in patients with pituitary tumors.</p><p><strong>Conclusion: </strong>For patients with pituitary tumors, neuroendoscopic transsphenoidal surgery is more effective than microscopic transsphenoidal surgery in reducing operative time and improving postoperative visual and pituitary function, and therefore, should be promoted in clinical practice.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1728-1741"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a predictive model for the relationship between serum pan-immunoinflammatory index levels and scar formation in facial burn patients.","authors":"Di Xi, Hailun Yu, Tong Yu","doi":"10.62347/OIFJ6585","DOIUrl":"https://doi.org/10.62347/OIFJ6585","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to develop a predictive model for scar risk in patients with facial burns using the Pan-Immune Inflammation Value (PIV) and other serological markers.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 367 patients with facial burns treated at a single institution between June 2021 and June 2023. Patients were categorized based on the presence of the scar 7 days post-treatment. Serum markers, including PIV, TNF-α, IL-10, EPO, TGF-β1, and ICAM-1, were measured. Multivariate logistic regression was employed to identify independent predictors of scar formation. A predictive model was developed and validated using a test set of 144 patients.</p><p><strong>Results: </strong>Scar formation was associated with elevated levels of TNF-α and ICAM-1, and reduced levels of IL-10, EPO, and TGF-β1, indicating a pro-inflammatory profile. Patients with scars showed higher symptom severity, emotional distress, and functional impairment. The predictive model, incorporating these markers, achieved an AUC of 0.815 in the training set and 0.845 in the test set, demonstrating good predictive performance.</p><p><strong>Conclusion: </strong>Elevated pro-inflammatory markers and altered PIV levels were significant predictors of scar formation in patients with facial burns.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2197-2209"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}