American journal of translational research最新文献

{"title":"Plasma hydrogen sulfide as a promising predictor of collateral cerebral circulation in acute ischemic stroke.","authors":"Haiyan Chen, Jianmin Huang, Pin Zheng, Guixin Yang, Bingbing Qin, Mengxue Zang, Jie Wang, Xuebin Li","doi":"10.62347/OTKA7544","DOIUrl":"10.62347/OTKA7544","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the relationship between plasma hydrogen sulfide (H₂S) levels and collateral circulation in patients with acute ischemic stroke (AIS), and to explore the effects of vascular endothelial growth factor (VEGF), homocysteine (Hcy), folic acid (FA), vitamin B₁₂ (VB₁₂), and vitamin B₆ (VB₆).</p><p><strong>Methods: </strong>A total of 68 AIS patients were enrolled and classified into two groups based on collateral vessel grading: the Good Collateral Circulation (GCC) group (n = 37) and the Poor Collateral Circulation (PCC) group (n = 31). Plasma levels of H₂S, VEGF, Hcy, FA, VB₁₂, and VB₆ were measured on the 2^nd and 7^th days after admission using microassays and ELISA.</p><p><strong>Results: </strong>Compared to the PCC group, patients in the GCC group had significantly lower National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale scores (mRS) scores at both admission and discharge (all P < 0.05). On both the 2^nd and 7^th days, plasma levels of H₂S, VEGF, FA, VB₁₂, and VB₆ were significantly higher in the GCC group, while Hcy levels were significantly lower (all P < 0.05). Within group comparisons between the two time points also showed significant changes (all <i>P</i> < 0.001). Correlation analysis revealed that plasma H₂S levels were positively correlated with collateral circulation, VEGF, FA, VB₁₂, and VB₆, and negatively correlated with Hcy levels (all <i>P</i> < 0.001). Plasma H₂S levels demonstrated high predictive value for collateral circulation (area under the curve, AUC = 0.943). An interaction between time and collateral circulation on H₂S levels was also observed.</p><p><strong>Conclusions: </strong>Plasma H₂S levels may serve as a valuable biomarker for predicting good collateral circulation in patients with acute ischemic stroke.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5562-5574"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedside inoculation accelerates detection and improves microbiological diagnosis efficiency compared to delayed inoculation.","authors":"Yulan Shi, Jingya Yu","doi":"10.62347/IJYI9617","DOIUrl":"10.62347/IJYI9617","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the differences in effects between bedside inoculation and traditional delayed inoculation methods in diagnosing wound infections, focusing on positivity rates, diagnostic cycles, and therapeutic outcomes.</p><p><strong>Methods: </strong>This prospective interventional study was conducted at the Wound Treatment Center of West China Hospital, Sichuan University, from April 2023 to July 2024. Patients were randomly assigned to a bedside inoculation group (n=132) or a delayed inoculation group (n=132). The effectiveness of the two methods was compared based on wound culture outcomes, bacterial species identified, detection of rare bacteria, wound healing rates, and patient satisfaction.</p><p><strong>Results: </strong>The bedside inoculation group had a significantly shorter detection report time compared to the delayed inoculation group (P<0.001). It also demonstrated a higher rate of detecting complex microbiomes (P=0.003). After 4 weeks, wound area reduction was significantly greater in the bedside group (P<0.001), and this difference remained significant at 8 weeks. The bedside group also had higher Barthel index scores (P<0.05), better wound healing scores (P<0.001), and greater patient satisfaction (P<0.001) than the delayed group.</p><p><strong>Conclusion: </strong>Bedside inoculation enhances wound infection diagnosis by accelerating result turnaround, reducing overtreatment, and promoting faster healing, ultimately improving patient care.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5575-5585"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined spinal-epidural anesthesia and epidural analgesia on pain and blood pressure in preeclamptic women undergoing painless delivery.","authors":"Dangding Yin, Huifang Li, Minjie Cui","doi":"10.62347/WQTE9989","DOIUrl":"10.62347/WQTE9989","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To analyze the impact of combined spinal-epidural anesthesia and epidural analgesia on pain and blood pressure in preeclamptic women undergoing painless delivery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on the clinical data of 137 preeclamptic women who underwent painless delivery at The Second People's Hospital of Linhai City between July 2022 and July 2024. Based on the type of analgesia intervention received, the women were divided into a control group (n=68, receiving Doula delivery analgesia) and an observation group (n=69, receiving combined spinal-epidural anesthesia and epidural analgesia). Labor duration, pain (assessed using the Visual Analogue Scale (VAS)), blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)], serum markers [prolactin (PRL), tissue-type plasminogen activator (t-PA)] levels, and maternal and neonatal outcomes were compared between the two groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;① Labor duration: Significant differences were observed between groups (F=10.279), over time (F=35.794), and in their interaction (F=16.589) (P &lt; 0.05). Within groups: both groups had shorter second and third stages of labor compared to the first stage (P &lt; 0.05). Between groups: no significant difference was observed in the second stage (P &gt; 0.05), but the observation group had shorter first and third stages than the control group (P &lt; 0.05). ② Pain: Significant differences were found between the groups (F=19.785), over time (F=8.637), and in their interaction (F=14.492) (P &lt; 0.05). Within groups: both groups had lower VAS scores in the 1-3 stages of labor compared to before analgesia (P &lt; 0.05). Between groups: no significant difference in VAS scores before analgesia (P &gt; 0.05), but the observation group had lower VAS scores in all stages than the control group (P &lt; 0.05). ③ Blood pressure: Significant differences in SBP were found between the groups (F=5.572), over time (F=10.295), and in their interaction (F=8.149) (P &lt; 0.05); similarly, significant differences in DBP were found between the groups (F=4.915), over time (F=9.761), and in their interaction (F=7.784) (P &lt; 0.05). Within groups: both groups had lower SBP and DBP levels at 10 minutes post-analgesia, during the active phase, and in the second stage of labor compared to before analgesia (P &lt; 0.05). Between groups: no significant difference in SBP and DBP levels before analgesia (P &gt; 0.05), but the observation group had lower SBP and DBP levels at 10 minutes post-analgesia, during the active phase, and in the second stage of labor compared to the control group (P &lt; 0.05). ④ Serum indicators: Both groups showed increased PRL and t-PA levels post-delivery compared to pre-delivery (P &lt; 0.05); the observation group had higher post-delivery PRL and lower t-PA levels compared to the control group (P &lt; 0.05). ⑤ Maternal and neonatal outcomes: The observation group had lower rates of cesarean section, postp","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5679-5688"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma SFRP2 hypermethylation as a diagnostic biomarker for dilated cardiomyopathy detected by methylation-specific PCR.","authors":"Zengyao Tang, Xin Huang, Zeqi Zheng, Hanying Mei","doi":"10.62347/OZQW6493","DOIUrl":"10.62347/OZQW6493","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical utility of plasma Secreted Frizzled-Related Protein 2 (SFRP2) gene hypermethylation as a non-invasive epigenetic biomarker for diagnosing Dilated cardiomyopathy (DCM) and stratifying cardiac function.</p><p><strong>Methods: </strong>A retrospective cohort of 482 participants (241 DCM patients and 241 healthy controls) was analyzed. DCM patients were further stratified by New York Heart Association (NYHA) class into better cardiac function (BCF; NYHA I-II) and poor cardiac function (PCF; NYHA III-IV) groups. Methylation-specific polymerase chain reaction (MSP) was used to assess SFRP2 methylation levels. Statistical analyses evaluated its diagnostic value, including receiver operating characteristic (ROC) curve analysis to determine sensitivity and specificity.</p><p><strong>Results: </strong>Plasma SFRP2 methylation levels were significantly higher in DCM patients than in controls (P < 0.001). ROC analysis revealed an area under the curve (AUC) of 0.942, indicating excellent diagnostic performance. Among DCM patients, the PCF group exhibited significantly higher SFRP2 methylation levels compared to the BCF group (P < 0.001). Additionally, SFRP2 methylation showed a strong positive correlation with worsening cardiac function (r = 0.786, P < 0.001).</p><p><strong>Conclusion: </strong>Elevated plasma SFRP2 methylation levels in DCM patients, particularly those with poor cardiac function, demonstrate its high diagnostic accuracy and potential to reflect disease severity, supporting its use as a non-invasive clinical biomarker for DCM diagnosis and risk stratification.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5423-5432"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application analysis of an internet platform tracking management mode combined with progressive resistance training in the rehabilitation of patients with breast cancer-related lymphedema.","authors":"Xiaofei Wu, Dongyang Zeng, Chuangyang Lin, Xiangwen Wang, Hongmei Xin","doi":"10.62347/GSXQ2189","DOIUrl":"10.62347/GSXQ2189","url":null,"abstract":"<p><strong>Objective: </strong>To observe the influence of internet platform tracking management mode combined with progressive resistance training (PRT) on the rehabilitation of patients with breast cancer-related lymphedema (BCRL).</p><p><strong>Methods: </strong>A total of 100 patients with BCRL admitted to Hainan general hospital from January 2023 to March 2024 were selected. After the shedding cases were excluded, they were divided into group A (n=47) where PRT + out-of-hospital follow-up were given, and group B (n=48) where PRT + Internet platform tracking management mode was given. The two groups were compared in peripheral diameter difference, volume difference, lymphatic flow, edema degree, grip strength, shoulder joint activity of the upper limbs, daily living function and quality of life.</p><p><strong>Results: </strong>The peripheral diameter difference, volume difference, proportion of severe edema and Disabilities of the Arm, Shoulder and Hand (DASH) scores of upper limbs in the two groups were decreased after 4 weeks and 12 weeks of intervention, while those in the group B were even lower (<i>P</i><0.05). The lymphatic flow, grip strength, abduction, rear extension level and proportion of mild edema in the upper limbs were increased after 4 weeks and 12 weeks of intervention, while those in the group B were even greater (<i>P</i><0.05). There was no statistically significant difference in anterior flexion level and quality of life score between the two groups before intervention, 4 and 12 weeks after intervention (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The application of the internet platform tracking management mode combined with PRT in patients with BCRL can reduce the degree of edema, improve the grip strength, enhance the shoulder joint activity, and improve the function of daily living.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5186-5194"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosapride combined with rebamipide demonstrates superior efficacy for treatment of chronic atrophic gastritis.","authors":"Sisi Shen, Jiawei Fei","doi":"10.62347/YMOB9811","DOIUrl":"10.62347/YMOB9811","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the therapeutic efficacy of combining mosapride with rebamipide for treatment of chronic atrophic gastritis (CAG).</p><p><strong>Methods: </strong>A total of 116 patients with confirmed CAG were enrolled. The control group (n=52) received mosapride alone, while the observation group (n=64) was treated with both mosapride and rebamipide. Therapeutic outcomes, adverse events, pathological scores, symptom relief time, and serological markers were compared between the groups. Univariate and multivariate analyses were also conducted to identify factors influencing treatment efficacy.</p><p><strong>Results: </strong>The observation group exhibited a significantly higher overall effective rate than the control group (P<0.05), with no significant difference in adverse events (P>0.05). Pathological scores were significantly lower in the observation group both compared to baseline and to the control group (P<0.05). Additionally, the observation group had greater improvements in all serological markers and a shorter duration to symptom relief (all P<0.05). Multivariate analysis identified smoking history (P=0.017, OR=4.318), alcohol consumption history (P=0.002, OR=6.327), and epidermal growth factor levels (P=0.044, OR=3.394) as independent risk factors for treatment response.</p><p><strong>Conclusion: </strong>The combination of mosapride and rebamipide offers superior efficacy in managing CAG without increasing adverse effects. It significantly improves pathological conditions, expedites symptom resolution, and enhances gastric mucosal biomarker profiles, supporting its broader clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5502-5510"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexplained cardiac hypertrophy as a clue to plasma cell tumour: a case study.","authors":"Sha Liu, Chengbi Tong, Junmin Xie, Shasha Zang","doi":"10.62347/YWDH3068","DOIUrl":"10.62347/YWDH3068","url":null,"abstract":"<p><p>Initial diagnosis: A 60-year-old male presented with initial diagnosis chest tightness, fatigue, and arrhythmia. Indications for plasma cell tumour: Initial imaging suggested amyloidosis due to myocardial thickening. Left ventricular hypertrophy and delayed enhancement on Magnetic Resonance Imaging (MRI), along with an elevated κ:λ ratio, raising suspicion for a plasma cell tumour. Confirmation of the plasma tumour: Further diagnostic tests, including immunofixation electrophoresis and myocardial biopsy, confirmed a plasma cell tumour. The patient was diagnosed with light chain (AL) amyloidosis, a subtype of plasma cell tumor, confirmed by bone marrow biopsy and immunohistochemistry. Treatment: Treatment with bortezomib, dexamethasone, and daratumumab resulted in significant symptomatic improvement. Conclusion: This case underscores the importance of considering plasma cell disorders in unexplained cardiac hypertrophy and highlights the need for early diagnostic strategies and targeted therapies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5195-5201"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial progenitor cell-derived microvesicles therapy relieves myocardial infarction symptoms by altering left ventricular protein expression.","authors":"Yanling Song, Shuai Wang, Huade Mai, Minghui Chen, Yunyun Lin, Huajun Wu, Shenhong Gu","doi":"10.62347/ZJOX1177","DOIUrl":"10.62347/ZJOX1177","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic potential of endothelial progenitor cell-derived microvesicles (EPC-MVs) in a rat myocardial infarction (MI) model, focusing on their effects on inflammation, apoptosis, and global proteomic changes in the left ventricle.</p><p><strong>Methods: </strong>Endothelial progenitor cells (EPCs) were isolated from mouse bone marrow, and microvesicles (MVs) were derived and injected into rats with MI induced by ligation of the left anterior descending artery. Therapeutic efficacy was assessed by measuring inflammatory cytokines (TNF-α, IL-6) and cardiac injury markers (creatine kinase-MB, myoglobin), along with histologic and apoptotic analyses. A global proteomic analysis of left ventricular tissue was performed to explore the underlying molecular mechanisms. Key targets, including components of the NLRP3 inflammasome (NLRP3, Caspase-1, apoptosis-associated speck-like protein containing a CARD), were validated by western blotting.</p><p><strong>Results: </strong>EPC-MV treatment significantly reduced MI-induced cardiac injury, as evidenced by decreased inflammatory cytokines and cardiac injury markers, preservation of myocardial architecture, reduced fibrosis, and suppression of cardiomyocyte apoptosis. Proteomic analysis revealed significant alterations in inflammatory and metabolic pathways, supported by KEGG and Reactome enrichment analyses. Molecular validation confirmed that EPC-MVs inhibited the activation of the NLRP3 inflammasome and downregulated downstream effectors, including IL-6 and atrial natriuretic peptide.</p><p><strong>Conclusion: </strong>EPC-MVs alleviated myocardial ischemic injury by remodeling the cardiac proteome, suppressing inflammatory and apoptotic signaling. These results position EPC-MVs as a promising cell-free therapeutic strategy for MI.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5332-5343"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarkers and clinicopathologic postoperative prognostic factors for in endometrial cancer patients.","authors":"Huiqiao Gao, Meizhu Xiao, Ying Feng, Jianxin Zhang","doi":"10.62347/VRHT7250","DOIUrl":"10.62347/VRHT7250","url":null,"abstract":"<p><strong>Objective: </strong>To explore the factors influencing the prognosis of endometrial cancer (EC) patients and assess their quality of life.</p><p><strong>Methods: </strong>A retrospective study was conducted involving 190 patients with EC who underwent surgical treatment in the Department of Obstetrics and Gynecology at Beijing Chao-Yang Hospital Affiliated to Capital Medical University between January 2008 and December 2018. Clinical and pathologic data were collected, and all patients received appropriate follow-up. Univariate analysis and Cox proportional hazards regression models were used to identify the factors related to EC prognosis and independent predictors of outcome. Additionally, the predictive performance of the serum biomarkers carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), and CA199 for patient prognosis were evaluated.</p><p><strong>Results: </strong>All 190 EC patients had complete clinical, pathologic, and follow-up data. The median survival time was 88.95 months, with a 5-year survival rate of 94.4%. Univariate analysis showed that older age, postmenopausal status, higher FIGO stage, deeper myometrial invasion, poorer tissue differentiation, lymph node metastasis, and receipt of postoperative chemotherapy and combined radiotherapy were significantly associated with worse prognosis (P<0.05). The sensitivities of CEA, CA125, and CA199 for predicting adverse prognosis were 86.7%, 97.6%, and 82.4%, respectively; specificities were 72.0%, 68.0%, and 80.0%, respectively. The areas under the receiver operating characteristic curves (AUCs) were 0.681, 0.867, and 0.853, respectively.</p><p><strong>Conclusion: </strong>Postoperative prognosis in patients with endometrial cancer is influenced by multiple clinical and pathological factors. Serological markers CEA, CA125, and CA199 demonstrated favorable predictive value.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5063-5071"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cai's gynecology chronic pelvic formula with acupuncture alleviates chronic pelvic pain and reduces recurrence in patients with pelvic inflammatory disease sequelae.","authors":"Jie Yin, Mengmeng Feng, Haiyang Xu","doi":"10.62347/YVFO2330","DOIUrl":"10.62347/YVFO2330","url":null,"abstract":"<p><strong>Objective: </strong>To assess the efficacy of Cai's Gynecology Chronic Pelvic Formula combined with acupuncture in managing chronic pelvic pain (CPP) secondary to pelvic inflammatory disease (PID) sequelae, and its effect on recurrence.</p><p><strong>Methods: </strong>A retrospective study assessed medical records from 240 CPP patients undergoing treatment between February 2019 and February 2024. Patients were divided into a control group (standard treatment, <i>n</i> = 120) and an observation group (standard treatment plus Cai's Chronic Pelvic Formula combined with acupuncture, <i>n</i> = 120), with treatment lasted for 28 days and follow-up for 6 months. The symptom scores (Visual Analog Scale, Self-rating Anxiety Scale and Self-rating Depression Scale), inflammatory markers [C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and cancer antigen 125 (CA125)], efficacy rates, and recurrence rates were all employed to measure treatment outcomes. Cox regression was leveraged to identify recurrence risk factors, while a nomogram model was developed and validated by Receiver Operating Characteristic (ROC), calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The observation group had significantly lower post-treatment Traditional Chinese Medicine symptom scores, inflammatory markers (CRP: <i>P</i> < 0.001; TNF-α: <i>P</i> = 0.003; IL-6: <i>P</i> = 0.004), and CA125 (<i>P</i> < 0.001) versus the control group. The observation group also demonstrated shorter symptom resolution time (<i>P</i> < 0.05), with higher total treatment efficacy in comparison to the control group (93.46% vs. 79.70%; <i>P</i> = 0.002). In addition, the observation group showed lower recurrence rates (14.2% vs. 28.3%; <i>P</i> = 0.008) as well as postponed recurrence time when compared to the control group. Cox regression analysis identified treatment protocol (HR = 0.41, 95% CI: 0.24-0.71), disease duration (HR = 1.32, 95% CI: 1.08-1.62), and pre-treatment CRP level (HR = 1.18, 95% CI: 1.02-1.36) as independent recurrence predictors. In addition, the nomogram demonstrated high accuracy in predicting disease recurrence (C-index = 0.852), with both ROC (AUC = 0.837) and calibration curves confirming its reliability. DCA indicated high clinical net benefit of the studying treatment protocol.</p><p><strong>Conclusion: </strong>Cai's Gynecology Chronic Pelvic Formula combined with acupuncture could significantly alleviate CPP and inflammation, and decrease recurrence rates. The nomogram may be used as a validated tool for predicting the disease recurrence, with benefits when integrated into clinical practice as a novel therapeutic strategy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5241-5256"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}