American journal of translational research最新文献

{"title":"Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.","authors":"Mengru Kang, Jianbin Cai, Weimin Yi, Bin Zhang, Liang Ai, Baile Ning, Jiayi Dong, Liudan Chen, Wenbin Fu","doi":"10.62347/PGKC2376","DOIUrl":"10.62347/PGKC2376","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the therapeutic effects and potential mechanism of electroacupuncture (EA) in a Parkinson's disease (PD) mouse model.</p><p><strong>Methods: </strong>C57BL/6 mice were randomly assigned to control, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), MPTP + sham EA, and MPTP + EA groups. PD was induced by MPTP. EA was applied at Baihui (GV20), Hegu (LI4), and Taichong (LR3). After 20 days of treatment, behavioral tests including the open field test, rotarod test, and Morris water maze were conducted. Dopaminergic neuron survival, apoptosis, and expression of inflammatory markers were assessed.</p><p><strong>Results: </strong>MPTP-induced mice exhibited impaired motor and cognitive performance, increased brain apoptosis, reduced dopaminergic neurons, and elevated expression of α-synuclein, NLRP3, IL-1β, IL-18, caspase-1, and gasdermin D. These changes were not significantly altered by sham EA. In contrast, EA significantly improved motor and cognitive function, reduced apoptosis, preserved dopaminergic neurons, increased tyrosine hydroxylase expression, and suppressed NLRP3 inflammasome activation.</p><p><strong>Conclusion: </strong>EA mitigates PD symptoms and exerts neuroprotective effects by inhibiting NLRP3 inflammasome-mediated neuroinflammation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3619-3629"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and establishment of a nomogram model for pulmonary arterial hypertension complicated by acute exacerbation of chronic obstructive pulmonary disease.","authors":"Haifeng Ye, Yaner Gu","doi":"10.62347/XMTE6690","DOIUrl":"10.62347/XMTE6690","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors for pulmonary arterial hypertension (PAH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and develop a nomogram model to facilitate early clinical identification of high-risk patients and guide personalized treatment plans.</p><p><strong>Methods: </strong>This retrospective study included 602 AECOPD patients treated at Zhoushan Women and Children's Hospital from June 2018 to May 2023. Patients were divided into two groups based on the presence or absence of PAH. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for AECOPD with PAH. A nomogram model was then established based on these factors. The Bootstrap self-sampling method was used to evaluate the predictive performance of the model. Indicators such as the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and consistency index (C-index) were calculated to evaluate the discrimination and calibration of the model.</p><p><strong>Results: </strong>Among 602 AECOPD patients, 8.31% developed PAH. Compared with the non-PAH group, the PAH group exhibited a higher proportion of Chronic Obstructive Lung Disease (GOLD) grade IV, hypertension, and elevated neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. Multivariate logistic regression analysis identified GOLD grade, hypertension, NLR, PLR, and NT-proBNP as independent risk factors for AECOPD-associated PAH. A nomogram prediction model was developed based on these variables. The model's AUC, sensitivity, and specificity in the training set were 0.906 (95% confidence interval (CI): 0.847-0.966), 0.850, and 0.862, respectively, and those in the validation set were 0.861 (95% CI: 0.715-0.932), 0.700, and 0.948, respectively. The C-index for the calibration curves of the model in both the training and validation sets was high (0.906 and 0.861, respectively). Decision curve analysis indicated a positive net benefit within a certain risk threshold.</p><p><strong>Conclusion: </strong>PAH in AECOPD patients was associated with GOLD grade, hypertension, NLR, PLR, and NT-proBNP. The developed nomogram demonstrated strong predictive performance and clinical utility.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3917-3927"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of polysomnography in obstructive sleep apnea-hypopnea syndrome patients with hypertension and secondary atherosclerosis.","authors":"Guangxi Chen, Min Zhang, Jing Zhou, Tao Wang, Mei Zhu, Zhiqiang Liu","doi":"10.62347/CYRN3387","DOIUrl":"10.62347/CYRN3387","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the utility of polysomnography (PSG) in diagnosing obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with hypertension who develop secondary atherosclerosis, and to identify effective indicators for predicting arterial sclerosis.</p><p><strong>Methods: </strong>140 OSAHS patients with hypertension diagnosed in Jiujiang NO. 1 People's Hospital from January 2021 to December 2023 were enrolled in this retrospective study and divided into two groups based on the presence of arteriosclerosis: the control group (without arteriosclerosis) and the research group (with arteriosclerosis). Univariate analysis, Pearson correlation analysis, and multivariate logistic regression analysis were used to identify independent factors affecting arteriosclerosis. The diagnostic performance of these factors were evaluated using a receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Compared with the control group, the research group showed significantly higher levels of fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein (LDL), apnea-hypopnea index (AHI), systolic blood pressure (SBP), and intima-media thickness (IMT), and a significantly lower level of minSpO₂ (<i>P</i><0.05). In patients with OSAHS and hypertension, FBG, TG, LDL, AHI, SBP, and IMT were positively correlated with secondary atherosclerotic diseases (r=0.273, 0.249, 0.190, 0.294, 0.198, 0.506, all <i>P</i><0.05), while minSpO₂ was negatively correlated with secondary atherosclerotic diseases (r=-0.199, <i>P</i><0.05). FBG, TG, LDL, AHI, minSpO₂, SBP, and IMT were identified as independent risk factors for the development of atherosclerosis in patients with OSAHS and hypertension (<i>P</i><0.05), with the area under the receiver operator characteristic curves of 0.668, 0.647, 0.636, 0.690, 0.636, 0.608, 0.805, and 0.922 for single and combined tests, respectively (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The AHI and minSpO₂ from PSG can predict arteriosclerosis. Combining them with FBG, TG, LDL, SBP, and IMT improves the accuracy of risk assessment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3928-3938"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of liberal fluid fasting on gastric fluid volume in patients undergoing painless gastroscopy: a randomized controlled study.","authors":"Jian-Sheng Luo, Wen-Cai Jiang, Xian-Jie Zhang, Chao Xiong, Juan Xie, Wen-Hu Zhai","doi":"10.62347/LLMS3494","DOIUrl":"10.62347/LLMS3494","url":null,"abstract":"<p><strong>Objective: </strong>This study assessed the impact of liberalized clear liquid intake on gastric fluid volume (GFV) in patients undergoing painless gastroscopy.</p><p><strong>Methods: </strong>184 patients scheduled for elective sedation gastroscopy underwent 1:1 randomization to a liberal fasting group (n = 92) or a conventional fasting group (n = 92). The liberal protocol permitted clear liquid consumption (≤150 mL/h) until 30 minutes pre-procedure, whereas the conventional group maintained standard preoperative 2-hour fasting. GFV quantification was performed through dual-modality assessment (gastric ultrasound and endoscopic aspiration). The primary endpoint was GFV, with secondary outcomes comprising fasting duration modifications, protocol satisfaction, adverse event incidence, and inter-method agreement.</p><p><strong>Results: </strong>No significant GFV differences emerged between groups as demonstrated by ultrasound or endoscopy. The liberal group demonstrated substantially shorter fasting durations and higher satisfaction scores, with comparable adverse event rates. Strong inter-method agreement was confirmed.</p><p><strong>Conclusion: </strong>Liberal fasting achieves equivalent GFV control compared to conventional protocols while optimizing patient comfort, supporting its safe implementation in painless gastroscopy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3514-3520"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Third-degree atrioventricular block induced by escitalopram and quetiapine in a patient with depression: a case report.","authors":"Chen-Jie Ge, Li-Lei Lei, Shi-Liang Wang, Xu-Qiang Hu","doi":"10.62347/JAKR2090","DOIUrl":"10.62347/JAKR2090","url":null,"abstract":"<p><p>Third-degree atrioventricular block (AVB) associated with the use of escitalopram and quetiapine is rare, with limited cases reported. We present a case of drug-induced third-degree AVB in an elderly patient undergoing treatment for depression. A 70-year-old woman with a history of depression was initially treated with milnacipran and alprazolam, but the regimen was altered due to insufficient therapeutic response. Two weeks after initiating escitalopram and quetiapine, she developed third-degree AVB. Electrocardiogram (ECG) revealed sinus rhythm with complete AV block, atrioventricular junctional escape rhythm, QT interval prolongation, and a heart rate of 45 bpm. Emergency pacemaker implantation was performed. This case highlights the potential for escitalopram and quetiapine to induce serious cardiac conduction abnormalities, particularly in elderly patients. Regular ECG monitoring is essential when prescribing these agents to minimize the risk of malignant arrhythmia.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"4062-4066"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between physical activity and common gynecologic conditions: a two-sample Mendelian randomization study.","authors":"Mengyu Fu, Xiaoyue Zhu, Jie Chen, Jiewen Guan, Hongmei Ding, Qinqin Gao, Songbing Qin","doi":"10.62347/PGYY9493","DOIUrl":"10.62347/PGYY9493","url":null,"abstract":"<p><strong>Objective: </strong>While physical activity (PA) patterns are epidemiologically linked to gynecologic pathologies, establishing causality remains uncertain. This Mendelian randomization (MR) study evaluated causal relationships between PA phenotypes and gynecologic disorders.</p><p><strong>Methods: </strong>Using European-ancestry female genome-wide association study (GWAS) data, we analyzed eight gynecologic disorders and four PA instruments. Primary inverse-variance weighted (IVW) estimates were supplemented by sensitivity analyses (MR-Egger, weighted median, MR-PRESSO) to address pleiotropy and heterogeneity.</p><p><strong>Results: </strong>Our MR revealed subtype-specific effects: walking for pleasure [OR = 0.63, 95% CI: 0.41-0.96], strenuous sports [OR = 0.34, 95% CI: 0.16-0.74], and other exercises [OR = 0.70, 95% CI: 0.49-0.99]) reduced ER⁺ breast cancer (BC) risk, while leisure screen time increased risk (OR = 1.08, 95% CI: 1.004-1.163). Only other exercises protected against ER^- BC (OR = 0.60, 95% CI: 0.38-0.96). Exercise frequency inversely correlated with endometrial cancer (EC) (walking: OR = 0.20; strenuous sports: OR = 0.06; other exercises: OR = 0.41) and endometriosis (ES) (strenuous sports: OR = 0.17; other exercises: OR = 0.26), but was positively associated with sedentary behavior (EC: OR = 1.36). Ovarian cyst (OCS) risk decreased with walking (OR = 0.34) and other exercises (OR = 0.28), yet increased with screen time (OR = 1.23). Paradoxically, walking showed strong positive (OR = 31.48) and strenuous exercise inverse (OR = 0.004) associations with polycystic ovary syndrome (PCOS). No causal links emerged for cervical cancer (CC), ovarian cancer (OC), or uterine fibroids (UF).</p><p><strong>Conclusion: </strong>This first MR evidence demonstrates PA's differential causal effects on gynecologic disorders, particularly highlighting exercise modality-specific protection against ER⁺ BC, EC, and ES. Paradoxical PCOS associations warrant mechanistic investigation. Findings underscore PA as a modifiable preventive factor and advocate for subtype-tailored exercise guidelines in women's health.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3753-3765"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"75% ethanol disinfection preserves biocompatibility and mechanical properties of swim bladder for cardiovascular applications.","authors":"Jia-Jun Pan, Chao Ye, Qin Li, Shi-Song Chen, Xiao-Ping Ning, Qi Yu, Bai-Ling Li, Xiao-Hong Liu, Zhi-Yun Xu","doi":"10.62347/OVKI5914","DOIUrl":"10.62347/OVKI5914","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effects of 75% ethanol on the disinfection efficacy, biocompatibility, extracellular matrix (ECM) integrity, and mechanical properties of swim bladders from <i>Hypophthalmichthys nobilis</i>, a promising biomaterial for cardiovascular applications.</p><p><strong>Methods: </strong>Swim bladders were immersed in 75% ethanol for 30, 60, or 120 minutes, followed by phosphate-buffered saline (PBS) rinsing. Disinfection efficacy was assessed using bacterial cultures; cytotoxicity and blood compatibility were evaluated using CCK-8 assays and hemolysis tests. The decellularization efficiency, ECM integrity, and mechanical properties were analyzed through histological staining, DNA quantification, and uniaxial tensile test.</p><p><strong>Results: </strong>75% ethanol effectively disinfected the swim bladder with minimal cytotoxicity and good hemocompatibility. Histological staining demonstrated preservation of collagen fibers, elastin, and glycosaminoglycans (GAGs), indicating minimal impact on the ECM structure. The uniaxial tensile test revealed that ethanol immersion caused tissue dehydration and increased stiffness, but these effects were reversible after PBS rinsing, with mechanical properties returning to baseline. DNA content and tissue thickness normalized following PBS washing, suggesting that ethanol did not impair decellularization.</p><p><strong>Conclusions: </strong>75% ethanol is an effective disinfectant for swim bladder biomaterials, preserving biocompatibility, ECM structure, and mechanical properties after rinsing. These findings support the use of swim bladder-derived scaffolds in cardiovascular tissue engineering applications.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3368-3379"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed uveitis after implantable Collamer lens Implantation caused by COVID-19 infection: a case report.","authors":"Yan Sun, Huiying Wu, Xingke Yan, Jibo Zhou, Tianyue Niu, Jie Zhu","doi":"10.62347/HHLS1617","DOIUrl":"10.62347/HHLS1617","url":null,"abstract":"<p><p>This report presents a case of uveitis secondary to ankylosing spondylitis (AS) with abnormal exudative deposits and pigment adhesion on the surface of an implantable Collamer lens (ICL) in a highly myopic eye following coronavirus disease 2019 (COVID-19) infection. The etiology and treatment were analyzed. A 22-year-old male presented with decreased visual acuity in the right eye, having undergone bilateral ICL implantation for high myopia 22 months prior. During the COVID-19 pandemic, he developed ocular exudation, pigment deposition, and vision deterioration, with a confirmed diagnosis of AS. Therapeutic interventions included anti-inflammatory, antiviral, and corticosteroid therapies. Postoperative uveitis secondary to AS following ICL implantation represents a rare complication. COVID-19 infection and concurrent systemic autoimmune disorders were identified as risk factors for secondary iridocyclitis. Immunological testing confirmed AS diagnosis. Treatment with sodium hyaluronate eye drops, ganciclovir ophthalmic gel, and systemic corticosteroids improved symptoms; however, persistent punctate exudates and pigment deposits on the ICL surface exhibited limited resolution. For patients with systemic autoimmune diseases or virus-induced uveitis undergoing ICL implantation, preoperative immunological screening should be actively performed to minimize postoperative complications. Early comprehensive therapy is critical to prevent progressive vision loss and rare transparency alterations of the ICL surface caused by pigment-laden exudates.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3565-3570"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting postoperative recurrence of auricular pseudocyst: key factors and risk models.","authors":"Guoling Zou, Chuandao Zeng, Chenyang Li, Wei Hu","doi":"10.62347/UDCK5613","DOIUrl":"10.62347/UDCK5613","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the factors influencing postoperative recurrence of auricular pseudocysts and to develop recurrence risk prediction models using logistic regression and Cox regression analyses.</p><p><strong>Methods: </strong>This retrospective study analyzed clinical data from 215 patients who underwent surgical treatment for auricular pseudocysts between January 2015 and December 2022. Univariate analysis identified factors associated with recurrence, which were further assessed using multivariate logistic regression and Cox regression. Recurrence prediction models were constructed, and their predictive performance was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC) values.</p><p><strong>Results: </strong>Univariate analysis identified age, cyst size, surgical approach, and postoperative adjuvant therapy as significant factors associated with postoperative recurrence (P<0.05). Multivariate logistic regression and Cox regression identified age <53.5 years, cyst size <2.5 cm, fenestration surgery, and absence of postoperative adjuvant therapy as protective factors against recurrence (P<0.05). The constructed models showed stable AUC values for 90-day and 120-day predictions (AUC = 0.718). No significant difference in predictive performance was observed between logistic regression and Cox regression models for 6-month recurrence risk (P = 0.934).</p><p><strong>Conclusion: </strong>Age, cyst size, surgical approach, and postoperative adjuvant therapy are critical factors influencing postoperative recurrence of auricular pseudocysts. The recurrence prediction models based on logistic regression and Cox regression demonstrate high efficiency in predicting short-term recurrence and can guide postoperative management strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3413-3423"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced efficacy of bisoprolol and digoxin combination in elderly patients with atrial fibrillation.","authors":"Chunmiao Yan, Duoxing Wu","doi":"10.62347/AKBG8366","DOIUrl":"10.62347/AKBG8366","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of combining bisoprolol and digoxin on cardiac function in elderly patients with atrial fibrillation (AF).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical records of 100 elderly AF patients treated at the Second Affiliated Hospital of Hainan Medical University from April 2020 to April 2023. Forty-six patients treated with digoxin alone were assigned to the control group, while the remaining 54 patients treated with bisoprolol in addition to digox comprised the study group. Outcome measures included cardiac function-associated indices (left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF)), ventricular rate at rest and during exercise, myocardial energy metabolism (plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and creatine kinase (CK)), and psychological status prior to and post therapy, and the overall response rate and adverse reactions. Multiple logistic regression was performed to identify independent risk factors for an unfavorable prognosis.</p><p><strong>Results: </strong>After treatment, LVEDD and LVESD levels significantly dropped in both groups (P<0.01), and LVEF level increased significantly (P<0.001), especially in the study group (P<0.01). Ventricular rate at rest and during exercise also decreased significantly in both groups (P<0.001), with a more pronounced effect in the study group (P<0.001). NT-proBNP and CK levels greatly decreased in both groups (P<0.001), especially the study group (P<0.001). The study group presented a notably higher overall response rate compared to the control group (P=0.011), but no significant inter-group difference was observed in the total incidence of adverse reactions (P=0.547). Both groups showed significant reductions in SAS and SDS scores after treatment (P<0.05), with a more substantial improvement in the study group (P<0.05). Logistics regression analysis identified comorbid diabetes mellitus (P=0.025; OR=6.086; 95% CI=1.250-29.638), comorbid hypertension (P=0.007; OR=7.059; 95% CI=1.728-28.842), New York Heart Association classification (P=0.023; OR=0.197; 95% CI=0.049-0.800), and treatment modality (P=0.020; OR=5.911; 95% CI=1.326-26.338) as independent risk factors for unfavorable prognosis.</p><p><strong>Conclusion: </strong>In contrast to digoxin alone, combined application of bisoprolol and digoxin is more effective in treating elderly AF patients. The combined treatment can significantly improve LVEDD, LVESD, LVEF, and ventricular rate without increasing adverse reactions, making it a promising approach for clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3630-3639"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}