American journal of translational research最新文献

{"title":"Breast skin merkel cell carcinoma: a case report.","authors":"Xinming Hou, Qian Lv, Zhaobao Lv","doi":"10.62347/YFTJ3672","DOIUrl":"10.62347/YFTJ3672","url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin malignancy characterized by high recurrence and metastasis rates. Here, we present a case of primary breast skin MCC in a 65-year-old female patient who initially presented with a peanut-sized lump on her right breast, which rapidly developed into a cauliflower-like mass accompanied by intermittent pain. The patient underwent radical surgery (right mastectomy and right axillary lymph node dissection), followed by postoperative chemotherapy. Immunohistochemical examination revealed positive staining for Cytokeratin 20 (CK20), Synaptophysin (Syn), Cluster of Differentiation 56 (CD56), and Chromogranin A (CgA), confirming the diagnosis of MCC. A subsequent Positron Emission Tomography - Computed Tomography (PET-CT) scan revealed secondary liver metastasis. Despite an initial effective response to chemotherapy, the patient developed severe bone marrow suppression, necessitating a switch to maintenance therapy with capecitabine.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3554-3559"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of three whitening protocols for mild-to-moderate dental fluorosis in anterior teeth.","authors":"Meixi Zhou, Linhong Zhu, Hua Lan","doi":"10.62347/RKQX9577","DOIUrl":"10.62347/RKQX9577","url":null,"abstract":"<p><strong>Objective: </strong>This research compares the effectiveness of three whitening treatments for mild-to-moderate dental fluorosis in the front teeth.</p><p><strong>Method: </strong>This retrospective study analysis is based on 51 mild-to-moderate dental fluorosis cases. The patients who visited the Dental Hospital of Ningxia Medical University from August 2020 to August 2021 were enrolled as research cases. The patients were classified into three groups according to their treatment plans: Group A (19 cases), Group B (17 cases), and Group C (15 cases). The upper anterior teeth color was assessed immediately after treatment and then at one week, one month, three months, and six months using the VITA Easyshade^® V shade guide. Tooth sensitivity was evaluated with a visual analog scale (VAS scale).</p><p><strong>Results: </strong>Three options were applied to treat mild and moderate dental fluorosis. Moderate fluorosis showed higher ΔE and ΔL values but lower Δa and Δb values compared to mild fluorosis, with significant differences noted (P<0.05). In cases of mild dental fluorosis, ΔE and ΔL values from the combination of micro-grinding and home bleaching were significantly higher. Conversely, Δa and Δb values for both micro-grinding with home bleaching and micro-grinding with combined bleaching were significantly lower (P<0.05). In moderate dental fluorosis cases, ΔE and ΔL values were higher for both micro-grinding combined with bleaching and micro-grinding combined with home bleaching. In contrast, Δa and Δb values for micro-grinding combined with bleaching were lower, showing statistically significant differences (P<0.05). The sensitivity of micro-grinding + home bleaching was less than that of micro-grinding + in-office bleaching and micro-grinding + combined bleaching immediately post-op, 1 week after the operation, with statistically significant differences (P<0.05).</p><p><strong>Conclusion: </strong>All three options achieve sound whitening effects for mild to moderate dental fluorosis in anterior teeth. The whitening effect is more effective in cases of moderate dental fluorosis than in mild cases. Among the three treatment options, microabrasion combined with home bleaching achieves the best whitening effect for mild dental fluorosis and minimizes sensitivity. When considering the three treatment options for moderate dental fluorosis, both microabrasion combined with home bleaching and microabrasion combined with in-office bleaching can yield better whitening effects. However, it is essential to note that the latter option is linked to higher sensitivity.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3454-3464"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of survival benefit and safety profile between lenvatinib and donafenib as conversion therapy in patients with hepatocellular carcinoma.","authors":"Yuehong Hou, Zhenlin Gao, Yaguang Han, Ci Liu, Xiaojuan Su, Dongliang Zhang","doi":"10.62347/PBLA2928","DOIUrl":"10.62347/PBLA2928","url":null,"abstract":"<p><strong>Objective: </strong>To compare the survival benefit and safety profiles between lenvatinib and donafenib when used as conversion therapies for patients with hepatocellular carcinoma (HCC) at the China National Liver Cancer (CNLC) stages I-III.</p><p><strong>Methods: </strong>A retrospective comparative study was conducted on 76 patients diagnosed with HCC at CNLC stage I-III. Among them, 40 patients were treated with lenvatinib, and the other 36 patients received donafenib. Key outcomes, including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and adverse events, were evaluated.</p><p><strong>Results: </strong>Patients treated with lenvatinib showed significantly longer OS (14.9 vs. 7.9 months, <i>P</i>=0.010) and PFS (4.6 vs. 2.9 months, <i>P</i><0.001) compared to those treated with donafenib. The ORR was 15% in the lenvatinib group and 5.6% in the donafenib group (<i>P</i>=0.551). Lenvatinib was also associated with a lower incidence of grade ≥3 adverse events (<i>P</i><0.05). Specifically, severe adverse events such as hepatotoxicity, hematological toxicity, hand-foot syndrome, and diarrhea were less frequent in the lenvatinib cohort. Univariate and multivariate analyses identified elevated alpha-fetoprotein (AFP) levels and the presence of hepatic vein tumor thrombus as significant predictors of poorer PFS, with hazard ratios (HR) of 1.45 and 1.80, respectively. Furthermore, multivariate analysis revealed that higher Child-Pugh scores and elevated AFP levels were associated with worse OS (all <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Lenvatinib demonstrates superior survival outcomes compared to donafenib as a conversion therapy in patients with CNLC stage I-III HCC. While the two therapies are comparable in overall safety profiles, lenvatinib is more tolerated, with a lower incidence of severe adverse events.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3496-3504"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an ECG-based nomogram for early diagnosis of dilated cardiomyopathy.","authors":"Tongping Huang, Xiaojuan Lv, Tao Yu, Xiaojun Wang, Guidong Cai","doi":"10.62347/QPZP2392","DOIUrl":"10.62347/QPZP2392","url":null,"abstract":"<p><strong>Objective: </strong>To develop a nomogram based on electrocardiogram (ECG) parameters to predict the early diagnosis of dilated cardiomyopathy (DCM), enhancing diagnostic accuracy and enabling earlier clinical intervention.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on ECG data from 168 DCM patients and 130 healthy controls (N-DCM), diagnosed between October 2022 and August 2024. Lasso regression identified 11 significant ECG features (e.g., QTc interval, PR interval, QRS duration), and a nomogram model was constructed. Model performance was evaluated using ROC curves, calibration curves, decision curves, and clinical utility curves.</p><p><strong>Results: </strong>Significant differences in ECG parameters were observed between DCM and N-DCM groups, with DCM patients showing elevated values across multiple parameters. The nomogram demonstrated high predictive accuracy, achieving an AUC of 0.928 in the training group and 0.862 in the validation group. Calibration and decision curve analyses confirmed good calibration and clinical utility.</p><p><strong>Conclusion: </strong>The ECG-based nomogram provides an effective tool for early DCM diagnosis, with strong predictive accuracy and clinical benefits. It shows promising applicability for large-scale screenings, contributing to earlier detection and improved patient outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3380-3391"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of comprehensive nursing interventions on psychological well-being and treatment adherence in dementia patients.","authors":"Xiaoqing Zhang, Yequn He, Haifang Li, Peiyi Li","doi":"10.62347/HOTG2720","DOIUrl":"10.62347/HOTG2720","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of comprehensive nursing interventions on psychological well-being and rehabilitation treatment adherence in patients with dementia.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 90 dementia patients treated at the First Hospital of Fuyang Hangzhou. Patients were divided into an observation group (n=45) and a control group (n=45). The control group received standard nursing care, while the observation group received comprehensive nursing interventions. Key outcomes included negative emotions, treatment adherence, quality of life, sleep quality, caregiver emotional well-being, and caregiver satisfaction.</p><p><strong>Results: </strong>The observation group had significantly lower Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores than the control group (both P<0.001). Treatment adherence, including disease awareness, medication compliance, and nutritional support, was significantly higher in the observation group (all P<0.05). The observation group showed better quality of lifeand lower Pittsburgh Sleep Quality Index (PSQI) scores (all P<0.001). Caregivers in the observation group reported higher satisfaction, with significantly lower SAS and SDS scores (all P<0.05). Mini-Mental State Examination (MMSE) scores were also higher in the observation group post-intervention (P<0.05). Additionally, the observation group had a better prognosis with fewer complications (P<0.05).</p><p><strong>Conclusion: </strong>Comprehensive nursing interventions significantly improve psychological well-being, treatment adherence, cognitive function, and overall quality of life for dementia patients. They also reduce anxiety, depression, and complications, and improve caregiver satisfaction. These findings support the benefits of comprehensive nursing interventions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3445-3453"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic pathways in anal fistula: paving the way for innovative treatments.","authors":"Minjie Wang, Yibin Pan, Xi Zhang, Chen Pan, Yongqing Cao","doi":"10.62347/UWZM3553","DOIUrl":"10.62347/UWZM3553","url":null,"abstract":"<p><strong>Background: </strong>Anal fistula, particularly in its cryptoglandular form, is a common yet challenging condition to treat, often resulting in poor healing and recurrent infections. Investigating the metabolic changes associated with anal fistula may offer valuable insights into its underlying mechanisms and assist in the development of more effective treatments.</p><p><strong>Methods: </strong>This study conducted a comprehensive analysis of serum samples from patients with various types of anal fistula and healthy controls. Metabolomic profiling was performed to identify differences in metabolic pathways between the groups.</p><p><strong>Results: </strong>The analysis revealed significant metabolic alterations in patients with anal fistula, particularly in fatty acid metabolism, sphingolipid metabolism, and amino acid metabolism. Notably, metabolites such as adrenic acid, LysoPC (22:5n6), and PC (18:0/22:4) were significantly associated with the progression of anal fistula. These metabolites could serve as biomarkers for the condition, with particular relevance in differentiating between acute and chronic stages.</p><p><strong>Conclusion: </strong>The study provides new insight into the metabolic basis of anal fistula, identifying specific metabolic pathways and metabolites that may play crucial roles in its progression. These findings may contribute to the development of targeted therapies for more effective treatment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"4023-4037"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma glial fibrillary acidic protein as a biomarker of blood-brain barrier integrity in patients with occult cerebral small vessel disease.","authors":"Peiqi Ma, Guangwei Gu, Lu Liu, Youmeng Wang, Juluo Chen","doi":"10.62347/MBFD3367","DOIUrl":"10.62347/MBFD3367","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between plasma glial fibrillary acidic protein (GFAP) levels and blood-brain barrier (BBB) integrity in patients with occult cerebral small vessel disease (CSVD).</p><p><strong>Methods: </strong>This retrospective study included patients with occult CSVD (CSVD group, n = 68) and age-matched individuals without CSVD (control group, n = 61). Demographic and clinical characteristics were compared between groups. Cognitive function was assessed using the Montreal Cognitive Assessment-B (MoCA-B). Plasma GFAP levels were measured, and all participants underwent sequential magnetic resonance imaging (MRI) to evaluate BBB integrity. Patients were stratified based on total MRI burden of CSVD into moderate/severe and none/mild load groups. Risk factors associated with moderate/severe CSVD load were analyzed.</p><p><strong>Results: </strong>The prevalence of hyperlipidemia was significantly higher in the CSVD group than in the control group (P = 0.020), and MoCA-B scores were significantly lower. In the CSVD group, plasma GFAP levels were negatively correlated with total cholesterol (r = -0.281, P = 0.020) and low-density lipoprotein (r = -0.282, P = 0.020), as well as with MoCA-B scores (r = -0.440, P = 0.0002). MRI analysis revealed that brain regions showing significant correlations with elevated plasma GFAP levels exhibited BBB disruption and cortical thinning.</p><p><strong>Conclusion: </strong>Elevated plasma GFAP levels are associated with cognitive impairment and BBB disruption in patients with occult CSVD. GFAP may serve as a potential biomarker for evaluating BBB integrity in this population.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3476-3484"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of uterine cavity manipulation history on clinical and neonatal outcomes for <i>in vitro</i> fertilization-embryo transfers with donor sperm.","authors":"Qin-Zi Mo, Ying Huang, Rong Li, Qian Huang","doi":"10.62347/SVQB2127","DOIUrl":"10.62347/SVQB2127","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of prior uterine cavity procedures on clinical and neonatal outcomes in patients undergoing first-time in vitro fertilization-embryo transfer with donor sperm (IVF-ET with DS).</p><p><strong>Methods: </strong>This retrospective cohort study included 599 infertility patients receiving their first IVF-ET with DS. Patients were categorized into two groups: those with a history of uterine cavity operation group (n=457) and the group with no history (n=142). The former was further subdivided into curettage (n=67), hysteroscopy (n=292), and complex uterine operations (n=98). Primary outcomes included clinical pregnancy outcomes (implantation rate, clinical pregnancy rate, miscarriage rate, and live birth rate) and neonatal outcomes (gestational age, birth weight and length, incidence of being small for gestational age [SGA], large for gestational age [LGA], and preterm birth).</p><p><strong>Results: </strong>No significant differences were found in clinical pregnancy outcomes between the non-operative, curettage, and complex operation groups (all P > 0.05). However, the hysteroscopy group showed significantly lower miscarriage rates and higher implantation, clinical pregnancy, and live birth rates (all P < 0.05). Multivariate analysis confirmed that hysteroscopy history was independently associated with improved pregnancy outcomes and reduced miscarriage rates, particularly in both age groups (< 35 and ≥ 35 years). No significant differences in neonatal outcomes were observed across all groups (all P > 0.05).</p><p><strong>Conclusion: </strong>A history of hysteroscopy is associated with improved implantation, clinical pregnancy, and live birth rates, and a lower miscarriage rate in patients undergoing first IVF-ET with DS, without affecting neonatal outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3802-3812"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local injection of platelet-rich plasma is effective for non-healing hand wounds.","authors":"Jiangqiang Chen, Zuhui Chen, Weibin Zheng, Xiangqian Shen","doi":"10.62347/CRQK7620","DOIUrl":"10.62347/CRQK7620","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of local platelet-rich plasma (PRP) injections in treating non-healing hand wounds.</p><p><strong>Methods: </strong>Data of 80 patients with non-healing hand wounds were retrospectively selected for this study. Among them, 48 patients in the research group received local PRP injections, while 32 patients in the control group were treated with conventional dressing changes. The outcomes assessed included treatment efficacy, safety, frequency of dressing change, wound healing time, duration of hospitalization, treatment costs, wound healing rate, wound infection rate, Vancouver Scar Scale (VSS) scores, Bates-Jensen Wound Assessment Tool (BWAT) scores, Visual Analogue Scale (VAS) scores, serum wound growth factors, and patient satisfaction with wound appearance.</p><p><strong>Results: </strong>The research group demonstrated significantly superior outcomes compared to the control group, including higher overall treatment efficacy and wound healing rates. Furthermore, the research group exhibited a significantly lower incidence of adverse events, reduced frequency of dressing changes, shorter wound healing time, reduced hospitalization duration, lower treatment costs, and a lower infection rate. Post-treatment assessments revealed significantly lower VSS, BWAT, and VAS scores in the research group. Additionally, the upregulation of serum wound growth factors was more pronounced in the research group following treatment.</p><p><strong>Conclusions: </strong>Local PRP injection demonstrates clear efficacy in the management of non-healing hand wounds.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3505-3513"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for neurodegenerative diseases: mechanisms, efficacy, and future research directions.","authors":"Xin Tang, Chen Wang, Shan Tian, Hejun Wen, Hong Zhang","doi":"10.62347/QFJO6227","DOIUrl":"10.62347/QFJO6227","url":null,"abstract":"<p><p>In recent years, acupuncture has shown good therapeutic efficacy in treating neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. Studies have demonstrated that acupuncture alleviates symptoms primarily by suppressing neuroinflammation, enhancing autophagy, improving synaptic plasticity, and optimizing mitochondrial function. As molecular research advances, the underlying mechanisms of acupuncture in these conditions have become increasingly clear. This review summarizes recent progress in understanding the efficacy and molecular mechanisms of acupuncture in neurodegenerative diseases, providing a theoretical support for its clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3703-3717"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}