American journal of translational research最新文献

{"title":"Clinical observation of percutaneous transforaminal endoscopic discectomy for lumbar disc herniation and analysis of influencing factors for recurrence.","authors":"Jie Li, Xu Wang","doi":"10.62347/AAIH8947","DOIUrl":"https://doi.org/10.62347/AAIH8947","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical effects of percutaneous transforaminal endoscopic discectomy (PELD) in treating lumbar disc herniation (LDH) and analyze the related factors for postoperative recurrence.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 168 patients with lumbar disc herniation who underwent percutaneous transforaminal endoscopy at the Second Hospital of Tangshan from January 2017 to January 2021. The patients were followed up for 1 year. The Oswestry disability index (ODI) and visual analog scale (VAS) for low back pain/radicular pain were recorded before the operation and at the final follow-up. The patients' overall responses were evaluated according to Stauffer-Coventry's response evaluation criteria. Univariate analysis and multivariate logistic regression were used to analyze the relationship between basic data indicators and postoperative recurrence.</p><p><strong>Results: </strong>Compared with preoperative values, the postoperative VAS scores and ODI indices were significantly reduced at different time points (both P < 0.05). During the final follow-up, the efficacy was rated as excellent in 55 cases, good in 59 cases, fair in 35 cases, and poor in 19 cases, with an overall excellent and good rate of 67.86%. Among them, 12 patients had postoperative recurrence, with a recurrence rate of 7.14%. Univariate analysis indicated that age ≥ 49 years, BMI ≥ 24.62 kg/m², partition of disc herniation location, intraoperative annulus fibrosus damage, and incomplete removal of nucleus pulposus during surgery were independent risk factors for postoperative recurrence (all P < 0.05).</p><p><strong>Conclusion: </strong>PELD surgery for LDH can achieve favorable clinical efficacy. However, intraoperative annulus fibrosus injury and incomplete removal of the nucleus pulposus during surgery may lead to secondary recurrence in patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2283-2292"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core decompression, allogenic fibula fixation, and pedicled fibula grafting are effective for osteonecrosis of femoral head.","authors":"Chuanqiang Dai, Youshu Zhang, Guifang Wu, Yao Zhang, Yao Dong","doi":"10.62347/SRDE9412","DOIUrl":"https://doi.org/10.62347/SRDE9412","url":null,"abstract":"<p><strong>Objective: </strong>To explore the application effects of core decompression, allograft fibula fixation, and pedicled fibula grafting in osteonecrosis of the femoral head (ONFH).</p><p><strong>Methods: </strong>Forty patients with ONFH admitted to Ziyang Central Hospital from March 2017 to March 2022 were included in this study. According to the Association Research Circulation Osseous (ARCO) staging criteria, 20 patients at stage I underwent core decompression, 8 patients at stage II underwent core decompression combined with allogenic fibula fixation, and 12 patients at stage III underwent core decompression combined with pedicled fibula grafting.</p><p><strong>Results: </strong>After 1 year of follow-up, changes in hip joint function (Harris score) and pain level (visual analogue scale (VAS)) were compared before and after surgery. Imaging examination results were recorded, and efficacy and ARCO stage progression were compared with preoperative findings. All 40 patients received follow-up for 1 year. The results showed that the Harris score at 1 year post-operation was higher than pre-operation, while the VAS score was lower (P<0.05). Hip joint function evaluation in the 20 patients at stage I showed excellent, good, and fair results in 12 (60.00%), 5 (25.00%), and 3 (15.00%) cases, respectively, with X-ray examination indicating complete stability and no progression in ARCO staging. Among the 8 patients at stage II, hip joint function evaluation showed excellent, good, fair, and poor results in 4 (50.00%), 2 (25.00%), 1 (12.50%), and 1 (12.50%) cases, respectively. X-ray examination revealed stability in 7 cases, while 1 case progressed to ARCO stage IV and ultimately required artificial hip arthroplasty. Among the 12 patients at stage III, hip joint function evaluation revealed excellent, good, fair, and poor results in 5 (41.67%), 3 (25.00%), 2 (16.67%), and 2 (16.67%) cases, respectively. X-ray examination indicated stability in 10 cases, while 2 cases progressed to ARCO stage IV and ultimately required artificial hip arthroplasty.</p><p><strong>Conclusion: </strong>Patients with stage I, II, and III ONFH achieved good short-term therapeutic outcomes using core decompression, core decompression with allogenic fibula fixation, and core decompression with pedicled fibula grafting. These methods effectively improved hip joint function and alleviated pain symptoms. Hence, it is crucial to select appropriate surgical methods based on the specific conditions of patients in clinical practice.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1768-1779"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of Q-switched 755-nm alexandrite laser combined with topical tranexamic acid in the treatment of melasma.","authors":"Xiarong Liu, Chengqi Liao","doi":"10.62347/YRNH5853","DOIUrl":"https://doi.org/10.62347/YRNH5853","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical value of Q-switched 755-nm alexandrite laser combined with topical tranexamic acid in treating melasma.</p><p><strong>Methods: </strong>A total of 121 melasma patients treated at AIST Medical Cosmetology Hospital from July 2022 to January 2024 were retrospectively included. They were divided into two groups: the Laser Treatment Group (LTG, n=61), receiving Q-switched 755-nm alexandrite laser combined with topical tranexamic acid, and the Control Treatment Group (CTG, n=60), receiving only topical tranexamic acid. Clinical efficacy, skin scores before and after treatment, laboratory indicators, melanin index, dermoscopic scores for pigmentation and vascular components, dermoscopic typing improvement, adverse reactions, and recurrence rates were compared.</p><p><strong>Results: </strong>The treatment efficacy rate was 93.44% in the LTG, significantly higher than 81.67% in the CTG (P<0.05). After treatment, the LTG showed significantly lower Melasma Area and Severity Index (MASI) scores, skin lesion color, and area scores compared to the CTG (all P<0.05). No significant differences were found in malondialdehyde (MDA) and superoxide dismutase (SOD) levels (both P>0.05). The LTG had a lower melanin index and dermoscopic scores for telangiectasia and perifollicular pigmentation than the CTG (all P<0.05). The incidence of adverse reactions in the LTG was 11.48%, significantly lower than 40.00% in the CTG (P<0.05). The LTG also had a lower recurrence rate of 1.64% at 6-month follow-up, compared to 10.00% in the CTG (P<0.05).</p><p><strong>Conclusion: </strong>Q-switched 755-nm alexandrite laser combined with topical tranexamic acid is highly effective in treating melasma, improving clinical symptoms, reducing oxidative stress and inflammation, and yielding better results in vascular proliferation and pigmentation. The treatment also demonstrated a low recurrence rate, suggesting its potential for broader use.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1651-1661"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of regorafenib combined with immunotherapy and arterial chemoembolization on the survival of patients with advanced hepatocellular carcinoma: a retrospective study.","authors":"Mingqiang Liu, Shaowu Zhuang, Junming Xu, Shaohua Zheng","doi":"10.62347/BXYO6569","DOIUrl":"https://doi.org/10.62347/BXYO6569","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of combining regorafenib with immunotherapy, and further adding transarterial chemoembolization (TACE), on the survival rates of patients suffering from advanced hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on clinical data from 219 patients with advanced HCC treated from January 2019 to December 2020 at Zhangzhou Affiliated Hospital of Fujian Medical University. Patients were divided into two groups: regorafenib combined with immunotherapy (Group A; n = 106) and regorafenib combined with immunotherapy plus TACE (Group B; n = 113). Assessment included baseline characteristics, serum indicators, treatment response, adverse events, progression-free survival (PFS), quality of life and overall survival (OS).</p><p><strong>Results: </strong>Six months after treatment, Group B demonstrated a significant decrease in α-fetoprotein (AFP) levels (<i>P</i> < 0.001), Alanine aminotransferase (ALT) levels (<i>P</i> < 0.001), and aspartate Aminotransferase (AST) levels (<i>P</i> < 0.001), along with a significant increase in albumin (ALB) levels (<i>P</i> = 0.010) compared to Group A. The addition of TACE resulted in higher partial response rates (PR) (<i>P</i> = 0.044), disease control rates (DCR) (P = 0.005), overall response rates (ORR) (<i>P</i> = 0.014), improved 1- and 2-year survival rates (<i>P</i> = 0.019, 0.025), and 6-month PFS rates (<i>P</i> = 0.003). However, this combination therapy was related to a higher incidence of grade 3-4 adverse events.</p><p><strong>Conclusion: </strong>Regorafenib combined with immunotherapy plus TACE may lead to improved short-term survival outcomes in advanced HCC patients, albeit with an increased risk of adverse events as well as possible effects on quality of life. These findings emphasize the complexity of treatment decisions in advanced HCC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1962-1973"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.","authors":"Qian Sun, Qian Cao, Zhen Gu, Peicheng He, Minmin Zhu, Xiao Liang","doi":"10.62347/LBNH3951","DOIUrl":"https://doi.org/10.62347/LBNH3951","url":null,"abstract":"<p><strong>Background: </strong>Muscle strength positively correlates with cognitive function, with the bidirectional causal link between hand grip strength and cognition posing a significant but incompletely understood public health challenge. This study aimed to explore the causal relationship between hand grip strength and cognition and its effect on dementia.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization analysis used genome-wide significant single nucleotide polymorphisms (SNPs) (P < 5×10^-8, at least P < 5×10^-6) linked to hand grip strength (right or left), cognition/dementia risk from the IEU Open GWAS project with 42,484 GWAS summary data sets. The primary analysis employed the inverse variance weighted method, while sensitivity analyses were conducted using the weighted mode and MR-Egger. These analyses aimed to assess the causal relationships between hand grip strength and cognition/dementia risk.</p><p><strong>Results: </strong>The inverse variance weighted (IVW) analysis indicated a directional positive causal effects of hand grip strength on cognition (Left-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.026)/performance (OR (95% Cl): 1.16 (1.04-1.30), P = 0.009); Right-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.031)/performance (OR (95% Cl): 1.10 (1.02-1.19), P = 0.018), with almost no reverse causality between cognitive function/performance and hand grip strength. Based on the results above, we then researched the directional causal effects of hand grip strength on neurodegenerative diseases (like dementia) with cognitive decline as the main clinical manifestation. However, the IVW methods yielded no evidence to support a causal effect of left-hand grip strength on dementia (P > 0.05).</p><p><strong>Conclusions: </strong>This MR study indicates a positive directional causal relationship between hand grip strength and cognition, with no observed causal link to dementia. These results hold implications for the development of public health measures and strategies for preventing cognitive decline.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1910-1924"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between ultrasound-measured inferior vena cava diameter and peripherally inserted central catheter measured central venous pressure in low birth weight infants.","authors":"Guang-Hong Li, Xiao-Qun Du, Dong-Sheng Sun, Hui-Yi Huang","doi":"10.62347/BMDJ4584","DOIUrl":"https://doi.org/10.62347/BMDJ4584","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the correlation between ultrasound-measured inferior vena cava (IVC) diameter and central venous pressure (CVP) measured by peripherally inserted central catheter (PICC) in low birth weight infants (LBWI) and explore potential influencing factors.</p><p><strong>Methods: </strong>This retrospective study included 120 LBWI with birth weights below 2500 g who required umbilical vein catheterization at Huadu District People's Hospital of Guangzhou from May 2022 to April 2024. Infants were categorized based on PICC catheterization into two groups. Clinical data, including ultrasound-measured IVC small diameter (SD) and large diameter (LD) at the level of the left portal vein, were collected. The SD/LD ratio (S/L) was calculated, and logistic regression analyses (univariate and multivariate) were performed to identify factors influencing PICC catheterization. Correlations between SD, LD, S/L, and CVP were analyzed.</p><p><strong>Results: </strong>Multivariate logistic regression identified gestational age, birth weight, SD, S/L, and CVP as significant factors influencing PICC catheterization in LBWI (all P < 0.05). SD and S/L showed a positive correlation with CVP (both P < 0.05). The S/L ratio was significantly correlated with gestational age, birth weight, ventilator mode, tricuspid regurgitation, and vasoactive drug use (all P < 0.05).</p><p><strong>Conclusion: </strong>Birth weight, SD, S/L ratio, and CVP are significant factors affecting PICC placement in LBWI. There is a notable correlation between ultrasound-measured IVC SD and S/L ratio and PICC-measured CVP in LBWIs.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2266-2275"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining serum biomarkers and MRI radiomics to predict treatment outcome after thermal ablation in hepatocellular carcinoma.","authors":"Ludong Zhao, Jing Wang, Jinna Song, Fenghua Zhang, Jinghua Liu","doi":"10.62347/TFRF1430","DOIUrl":"https://doi.org/10.62347/TFRF1430","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the predictive value of serum alpha - fetoprotein (AFP), lectin-reactive alpha-fetoprotein (AFP-L3), and multimodal magnetic resonance imaging (MRI) radiomics in forecasting therapeutic efficacy and prognosis following radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on HCC patients who underwent RFA between January 2019 and December 2023. Clinical and radiologic features of HCC were analyzed. A predictive model was developed using clinical data and radiomic features collected before surgery, with the goal of predicting prognosis after RFA. The predictive performance of the model was evaluated using AUC values in both training and validation cohorts.</p><p><strong>Results: </strong>A total of 298 HCC patients were included in the study, divided into a good prognosis group (n=145) and a poor prognosis group (n=153). Serum AFP and AFP-L3 levels were significantly higher in the poor prognosis group (P=0.007 and P=0.02, respectively). Independent predictive factors included: AFP-L3 (95% CI -1.228, -1.1.61; P<0.001), AFP (95% CI 0.017, 0.036; P<0.001), intratumoral hemorrhage (95% CI 0.380, 0.581; P<0.001), peritumoral arterial tumor enhancement (95% CI 0.193, 0.534; P<0.001) and low signal intensity around liver and gallbladder tumors (95% CI 0.267, 0.489; P<0.001). The combined clinical-radiological-radiomics model demonstrated superior predictive performance, with AUC value of 0.897 in the training set and 0.841 in the validation set, outperforming individual models and sequences.</p><p><strong>Conclusion: </strong>The integrated clinical-radiological-radiomics model showed excellent predictive performance for the prognosis of HCC patients undergoing RFA, surpassing individual models. Key predictors included serum AFP, AFP-L3 levels, intratumoral hemorrhage, and peritumoral low signal intensity. This multimodal approach offers a promising tool for individualized prognostic assessment and improved clinical decision-making.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2031-2043"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restrictive fluid resuscitation versus liberal fluid resuscitation in patients with septic shock: comparison of outcomes.","authors":"Dengkai Li, Chunfang Zhang, Yun Yang, Lei Liu","doi":"10.62347/PGBB6148","DOIUrl":"https://doi.org/10.62347/PGBB6148","url":null,"abstract":"<p><strong>Objective: </strong>To compare the prognosis of restrictive fluid resuscitation (RFR) versus liberal fluid resuscitation (LFR) in patients with septic shock.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using clinical data from 82 septic shock patients treated in the Intensive Care Unit of Aviation General Hospital from January 2021 to December 2023. Patients were divided into two groups: the LFR group (n=41) and the RFR group (n=41), based on the resuscitation strategy used.</p><p><strong>Results: </strong>Both groups demonstrated significant reductions in heart rate (HR) and significant increases in mean arterial pressure (MAP) and central venous pressure (CVP) post-treatment (all P < 0.05). After treatment, the ejection fraction (EF) and cardiac index (CI) were significantly higher in the RFR group compared to the LFR group, while levels of troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were significantly lower in the RFR group (all P < 0.05). After treatment, the Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores exhibited a marked decrease in both groups, with the RFR group exhibiting greater reductions in both scales compared to the LFR group (both P < 0.05). The incidence of complications was significantly lower in the RFR group than in the LFR group (P < 0.05). Multivariable analysis identified age and fluid resuscitation modality as risk factors for complications in septic shock.</p><p><strong>Conclusions: </strong>In patients with septic shock, RFR, compared to LFR, appears to better maintain hemodynamic stability and reduce myocardial injury. It also enhances cardiac function, mitigates organ failure, and lowers complication rates, possibly facilitating faster recovery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2311-2321"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical investigation of extracorporeal shock wave therapy combined with kinesitherapy on the treatment of delayed union of tibia and fibula fractures.","authors":"Qing Yang, Feng Xu, Jing Zhu, Li Sun, Qingming Qu, Su Liu, Siye Wang","doi":"10.62347/WWFD7121","DOIUrl":"https://doi.org/10.62347/WWFD7121","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic efficacy of extracorporeal shock wave therapy (ESWT) combined with kinesitherapy (KT) for the treatment of delayed union of tibia and fibula fractures.</p><p><strong>Methods: </strong>A total of 68 patients with delayed healing of tibiofibular fractures were enrolled. These patients were divided into three groups: control, ESWT, and ESWT+KT. All patients underwent standard surgical treatment following the fracture. Patients in the ESWT group received shockwave therapy twice a week for 4 months, while those in the ESWT+KT group received additional exercise therapy twice a week over the same duration. The control group did not receive any specific intervention during this period. The pain levels of patients in all three groups were assessed using the Numerical Rating Scale (NRS) before and after treatment. Bone repair and callus formation were evaluated using the Lane-Sandhu and Fernandez-Esteve X-ray grading scales before and after treatment. Additionally, walking ability was assessed using the Functional Ambulation Classification (FAC), Hoffer walking ability grade, and Holden walking ability grade before and after treatment.</p><p><strong>Results: </strong>No significant differences were observed in patient baseline characteristics across the three groups (<i>P</i> > 0.05), indicating comparability among groups. Post-treatment, improvements were noted in the NRS, Lane-Sandhu X-ray scale, Fernandez-Esteve X-ray scale, FAC level, Hoffer grade, and Holden grade in all three groups compared to their respective pre-treatment values (<i>P</i> < 0.05). Notably, the Lane-Sandhu X-ray scale, FAC level, Hoffer grade, and Holden grade showed significant improvements in the ESWT+KT group after treatment compared to the control group (<i>P</i> < 0.05). Additionally, the ESWT group demonstrated significant improvements in FAC level and Holden grade compared to the control group after treatment (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>ESWT can enhance the walking function in patients with delayed union of tibia and fibula fractures. ESWT combined with KT demonstrates superior efficacy compared to monotherapy, as it not only improves walking function but also promotes bone healing.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1860-1871"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified inverted 'L' epicanthoplasty combined with incisional blepharoplasty for epicanthal folds and single eyelids: a clinical outcomes study.","authors":"Liyun Long, Linhai Xie, Hao Zeng, Qinghong Lai, Jinjing Liu, Wuqiang Liao","doi":"10.62347/QAPY8097","DOIUrl":"https://doi.org/10.62347/QAPY8097","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical outcomes of a modified inverted 'L' epicanthoplasty combined with incisional blepharoplasty for correcting epicanthal folds and single eyelids in patients of Mongoloid descent.</p><p><strong>Methods: </strong>This observational study included 100 female patients aged 20 to 38 years, who underwent the combined procedure from January 2018 to September 2024 at Ganzhou People's Hospital. The modified technique utilized a specific marking and incision approach to address the epicanthal folds and create a double eyelid, with an emphasis on minimizing scarring and optimizing aesthetic outcomes. Local anesthesia was used, followed by meticulous dissection, fixation of the medial canthal ligament, and careful skin closure. Postoperative care included pressure dressing and ice packs, with follow-up visits at 1 week, 1 month, and 3 months. The observed indexes included the total effectiveness rate, changes in palpebral fissure measurements, patient satisfaction, and the incidence of postoperative adverse events.</p><p><strong>Results: </strong>The overall effectiveness rate was 97.0%, with 60.0% of patients showing significant improvement and 37% achieving moderate outcomes. Three patients (3.00%) were dissatisfied with the outcomes. Postoperative palpebral fissure measurements showed significant improvement. Follow-up assessments indicated a high patient satisfaction rate of 97.0%, with minor complications in two cases, which were managed conservatively.</p><p><strong>Conclusion: </strong>The modified inverted 'L' epicanthoplasty combined with incisional blepharoplasty is an effective and aesthetically pleasing procedure for correcting epicanthal folds and creating double eyelids. Its simplicity, minimal scaring, and high patient satisfaction make it a valuable approach in oculoplastic surgery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2014-2022"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}