American journal of translational research最新文献

{"title":"LncRNA HCP5 promotes the progression of gastric cancer through the miR-526b/PBX3 axis.","authors":"Guang-Chuan Mu, Xue-Yu Zeng, Chao-Zhen Hu","doi":"10.62347/IOYF4383","DOIUrl":"10.62347/IOYF4383","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether LncRNA HLA complex P5 (HCP5) promotes gastric cancer (GC) via the miR-526b/Pre-B Cell Leukemia Homeobox 3 (PBX3) pathway.</p><p><strong>Methods: </strong>Thirteen paired GC and adjacent non-tumorous tissues, along with NCI-N87 GC cells, were analyzed. HCP5 expression levels were measured, and its impact on cell viability, proliferation, and migration were evaluated. Dual-luciferase reporter assays were performed to confirm the direct interactions among HCP5, miR-526b, and PBX3. The effects of HCP5 overexpression or silencing on miR-526b and PBX3 expression were analyzed. A miR-526b mimic was transfected for functional rescue.</p><p><strong>Results: </strong>HCP5 was significantly upregulated, while miR-526b was downregulated in GC tissues. Dual-luciferase assays confirmed the direct binding of HCP5 to miR-526b and of miR-526b to PBX3. In NCI-N87 cells, HCP5 overexpression downregulated miR-526b and upregulated PBX3 expression, whereas silencing HCP5 showed the opposite effects. Moreover, HCP5 overexpression decreased Bax and increased Bcl-2 levels, which was reversed by miR-526b mimic transfection. Functionally, HCP5 enhanced GC cell viability and migration, both of which were suppressed by miR-526b. HCP5 promoted cell proliferation, as evidenced by a reduced proportion of cells in the G0/G1 phase, which was reversed by miR-526b.</p><p><strong>Conclusions: </strong>HCP5 acts as an oncogenic lncRNA in GC by promoting cell viability, migration, and proliferation via the miR-526b/PBX3 axis. Targeting the HCP5/miR-526b/PBX3 axis may represent a promising therapeutic strategy for GC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5602-5613"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical thrombectomy combined with tirofiban for treatment of acute intracranial atherosclerotic cerebral infarction: clinical observations and effect on serum inflammatory factors.","authors":"Ben-Yang Chen, Yu-Zhang Bei, Jian-Huang Chen, Wei-Li Bai","doi":"10.62347/FJGC1286","DOIUrl":"10.62347/FJGC1286","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of mechanical thrombectomy (MT) combined with tirofiban in treating acute intracranial large artery atheromatous cerebral infarction and its effect on inflammatory factor levels.</p><p><strong>Methods: </strong>This retrospective study included 102 patients with acute intracranial large atherosclerotic cerebral infarction admitted to Jili Hospital, Liuyang City, Hunan Province, between December 2022 and December 2024. Patients were divided into a control group (MT) and an observation group (MT + tirofiban). Pre-treatment and post-treatment assessments included revascularization rate, hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), D-dimer (D-D), prothrombin time (PT), activated partial thromboplastin time (APTT), neuron-specific enolase (NSE), central neural specific protein (S100β), and myelin basic protein (MBP). Neurological function was evaluated using the National Institutes of Health Stroke Scale (NIHSS), Mini-Mental State Examination (MMSE), modified Barthel index (MBI), and Fugl-Meyer assessment (FMA). Logistic analysis was used to identify factors influencing vascular re-canalization.</p><p><strong>Results: </strong>After treatment, the revascularization rate was higher in the observation group (94.12% vs. 78.43%, P<0.05). NIHSS, D-D, hs-CRP, TNF-α, IL-6, NSE, S100β, and MBP levels decreased significantly, with lower values observed in the observation group (P<0.05). MMSE, MBI, and FMA scores increased more in the observation group (P<0.05). PT and APTT were prolonged significantly, with higher values in the observation group (P<0.05). Logistic regression identified post-treatment NIHSS score as an independent risk factor for re-occlusion (P<0.05).</p><p><strong>Conclusion: </strong>Tirofiban combined with MT improves revascularization in patients, reduces inflammation and neurobiochemical damage, enhances neurological function, and lowers the risk of re-occlusion in patients with acute intracranial large artery atheromatous cerebral infarction.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5689-5697"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofeedback magnetic stimulation improves postoperative bowel dysfunction after rectal cancer surgery.","authors":"Yang Lin, Gang Mao, Jinghua Liang, Lu Liu","doi":"10.62347/XBDR6986","DOIUrl":"10.62347/XBDR6986","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of biofeedback magnetic stimulation (BFMS) in the management of postoperative bowel dysfunction (PBD) after rectal cancer surgery and to identify independent predictors of treatment outcomes.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving 158 patients who underwent low anterior resection between 2018 and 2023. Patients were divided into two groups: the observation group, consisting of 83 individuals, received BFMS; whereas the control group, comprising 75 individuals, underwent conventional rehabilitation. Defecation function, anorectal manometric parameters - including resting and pressure (RAP), maximum squeeze pressure (MSP), and maximum tolerated volume (MTV) - as well as Wexner scores and QLQ-CR29 quality-of-life scores were assessed at 1, 2, and 3 months postoperatively.</p><p><strong>Results: </strong>At 2 and 3 months postoperatively, the observation group showed significantly greater improvement in defecation function, anorectal pressure metrics, and quality of life scores compared to controls (P<0.05). The incidence of adverse reactions was comparable between groups (14.46% vs. 6.67%, P>0.05). Multivariate analysis revealed that anastomotic leakage, ultra-low rectal cancer, interspinous diameter, and treatment method were independent predictors of postoperative outcomes (P<0.05).</p><p><strong>Conclusion: </strong>BFMS is a safe and effective therapeutic approach for improving bowel function and quality of life in patients with PBD after rectal cancer surgery. Anatomical and surgical variables may serve as important predictors of treatment response.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5667-5678"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of hospital-acquired infections in patients with multiple myeloma: a study of 200 cases.","authors":"Hece Cai, Fugui Sun, Weihua Shen, Xianghai Bian","doi":"10.62347/ZGYB9556","DOIUrl":"10.62347/ZGYB9556","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics of hospital-acquired infections (HAIs) in patients undergoing treatment for multiple myeloma.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 200 patients with multiple myeloma treated at Haiyan County People's Hospital in Jiaxing. The incidence rate, sites of infection, and causative pathogens of HAIs were recorded. Patients were divided into an infection group (n=37) and a non-infection group (n=163) based on the presence of HAIs. According to follow-up outcomes, they were further classified into a recurrence group (n=76) and a non-recurrence group (n=124). Risk factors associated with HAIs in patients with multiple myeloma were analyzed, and the predictive value of serum immunoglobulin A (IgA) and immunoglobulin G (IgG) levels for the recurrence of multiple myeloma was assessed.</p><p><strong>Results: </strong>Among the 200 patients with multiple myeloma, the incidence of HAIs was 18.5%. The respiratory tract was the most commonly affected site, with Gram-negative bacilli being the predominant pathogens. Multivariate logistic regression analysis identified neutropenia, age ≥60 years, chemotherapy, low serum albumin levels, high Revised International Staging System (R-ISS) stage, elevated body mass index (BMI), and comorbid diabetes mellitus as significant risk factors for infection following multiple myeloma treatment (all P<0.05). In addition, receiver operating characteristic (ROC) analysis revealed that serum IgA and IgG levels were strong predictors for recurrence in patients with multiple myeloma, with area under the curve (AUC) values of 0.936 and 0.914, respectively. IgA showed a sensitivity of 97.8% and specificity of 93.5%, while IgG demonstrated a sensitivity of 83.3% and specificity of 80.0%.</p><p><strong>Conclusion: </strong>Patients with multiple myeloma are at increased risk of developing HAIs after treatment, particularly respiratory infections caused by Gram-negative bacilli. Moreover, serum IgA and IgG levels may serve as reliable biomarkers for predicting disease recurrence.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5757-5765"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YAG laser combined with mechanical debridement enhances pain relief and inflammation control in the management of periodontitis with peri-implantitis.","authors":"Dawei Sun, Zhiqiang Li, Daxu Li, Baolei Wu, Yiwei Ma","doi":"10.62347/VIOT6629","DOIUrl":"10.62347/VIOT6629","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of Er: YAG laser combined with mechanical debridement in treating periodontitis with peri-implantitis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 292 patients treated between 2018 and 2024. The patients were divided into an observation group (n=139, Er: YAG laser + mechanical debridement) and a control group (n=153, mechanical debridement only). Outcome measures included Visual Analog Scale (VAS) scores, periodontal probing depth (PD), clinical attachment level (CAL), bleeding index (BI), gingival index (GI), and TNF-α/IL-6 levels. Clinical efficacy and risk factors for treatment failure were analyzed using logistic regression.</p><p><strong>Results: </strong>The observation group exhibited a significantly higher total efficacy rate than the control group (89.21% vs. 64.71%, P<0.001). Additionally, VAS scores, PD, CAL, BI, GI, and TNF-α/IL-6 levels were significantly lower at 1 week, 2 weeks, and 1 month post-treatment in the observation group (all P<0.05). Multivariate logistic regression identified age (OR=1.12, 95% CI: 1.07-1.18, P<0.001), smoking (OR=6.21, 95% CI: 2.96-13.82, P<0.001), and diabetes (OR=5.74, 95% CI: 2.71-12.94, P<0.001) as independent risk factors for treatment failure, while postprandial gargling (OR=0.28, P=0.002) was identified as a protective factor.</p><p><strong>Conclusion: </strong>Er: YAG laser combined with mechanical debridement significantly reduced pain and inflammation, improving peri-implant health. Smoking, diabetes, and age increased treatment failure risk, while postprandial gargling was protective, underscoring the importance of personalized treatment strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5698-5709"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of marginal sclerosis in the recovery of mechanical strength after curettage of bone lesions.","authors":"Francisco de As Baima Filho, Priscylla G Mendonça, Giuliano F Morgantetti, Alice C Silva-Sousa, Leonardo R Battaglion, Ramon Syrc Silva, Maria do S de S Cartagenes, Edgard E Engel","doi":"10.62347/GZLN4148","DOIUrl":"10.62347/GZLN4148","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the role of marginal sclerosis in the recovery of mechanical strength following curettage and grafting of osseous lesions. To date, it remains unclear as to whether marginal sclerosis fully or partially restores the mechanical resistance of the affected bone to compressive, flexural, and torsional loads.</p><p><strong>Methodology: </strong>Adult male <i>Rattus norvegicus</i> rats (WISTAR albino strain) aged approximately 90-days were used. Bone defects were created in the tibiae, and the animals were subsequently euthanized at different time points for outcome analysis. Various assessment methods were employed, including radiography, histology, immunohistochemistry, microcomputed tomography (micro-CT), mechanical bending and torsion tests.</p><p><strong>Results: </strong>This study revealed a progressive thickening of the osseous window borders before complete closure and a significant correlation between the intensity of marginal sclerosis that was radiographically observed, the rate of bone formation on histology, and the newly formed bone volume on micro-CT. Radiographs revealed thin marginal sclerosis at seven days post surgery, with a significant increase in sclerosis thickness being observed at ten days, whereas micro-CT revealed proportions of new bone formation of 44.80% at seven days and 105.70% at ten days. Additionally, at seven days, the mechanical resistance of the operated bones to torsion and bending was comparable to that of the non-operated bones, thereby indicating a complete recovery of mechanical strength.</p><p><strong>Conclusion: </strong>This study revealed that the appearance of marginal sclerosis around bone defects (as identified by radiography) is associated with the complete recovery of mechanical strength in rat tibiae under both bending and torsion.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5641-5653"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the association of IL-17A and IL-17F polymorphisms with osteoarthritis risk: a systematic review and meta-analysis.","authors":"Ran Xu, Xin Liu, Fan Zhou, Jie Liu, Dunyao Bai","doi":"10.62347/SUPA1847","DOIUrl":"10.62347/SUPA1847","url":null,"abstract":"<p><p>We conducted a systematic review and meta-analysis to clarify the relationship between these gene polymorphisms and Osteoarthritis (OA) risk. We searched electronic databases and found 736 related reports, five of which were ultimately included in the study. The articles ranged from 2014 to 2019 and included both Asian and Caucasian populations. Genotypes were categorized into TT, TC, and CC across case and control groups. The meta-analysis of interleukin-17A (IL-17A; rs2275913) showed no significant correlation with OA in the overall human population's allele model, codominance model, dominance model, and recessive model (P=0.97, 0.94, 0.77, 0.80, 0.85). Ethnic subgroup analysis showed no association between the Asian or Caucasian populations' IL-17A gene and OA. However, the meta-analysis of interleukin-17F (IL-17F; rs763780) showed that this gene is related to OA in the overall population and each single nucleotide polymorphism (SNP) genetic model (<i>P</i>-values: 0.0001, 0.0003, 0.01, 0.01, 0.0008). Ethnic subgroup analysis revealed that the IL-17F gene in the Asian population is related to OA, but only the allele and dominant models of the IL-17F gene in the Caucasian population were related to OA. The IL-17F polymorphism appears to be a risk factor for OA, with Asian populations more susceptible than Caucasians. The IL-17A showed no association with OA.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5654-5666"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a gradient boosting machine-based model for predicting tumor-infiltrating lymphocyte proportions in breast cancer.","authors":"Xiaobin Zhang, Shulin Xian, Daolai Huang, Naihan Cui, Jiehua Li","doi":"10.62347/PDEW5000","DOIUrl":"10.62347/PDEW5000","url":null,"abstract":"<p><strong>Objective: </strong>To construct and validate a multidimensional model for evaluating tumor-infiltrating lymphocyte (TIL) levels in breast cancer (BC) patients.</p><p><strong>Methods: </strong>This retrospective study included 318 BC patients with 318 lesions confirmed by MRI and surgical pathology in the First Affiliated Hospital of Guangxi Medical University from January 2021 to December 2024. The patients were randomly split into a training set (n=228) and a validation (n=90) set, and further divided into low and high TIL groups based on immunophenotype assessment. Multivariate Logistic regression was used to identify independent predictors of TILs levels. A gradient boosting machine (GBM) model and a Logistic regression model were built. Model performance was assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). An external validation cohort of 120 BC patients admitted between January 2025 and May 2025 was used to verify the predictive accuracy of the GBM model. Results Ki-67 level, internal enhancement pattern, multifocality, apparent diffusion coefficient (ADC) value, and neutrophil-to-lymphocyte ratio (NLR) were identified as independent predictors of high TIL levels. The GBM model demonstrated superior performance compared to the Logistic regression in the training set (AUC: 0.859 vs 0.724; P=0.014). Calibration curves indicated good agreement between predicted and observed probabilities in both models. DCA showed that the GBM model provided higher clinical utility. External validation yielded an AUC of 0.784 for the GBM model, with the calibration curve and DCA further confirming the model's good calibration and clinical applicability.</p><p><strong>Conclusion: </strong>The GBM-based multidimensional model reliably predicts TIL levels in BC patients, supporting prognosis evaluation and guiding personalized treatment strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5586-5601"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a carbon nanoparticle-guided nomogram for predicting lateral cervical lymph node metastasis in clinically node-negative papillary thyroid carcinoma.","authors":"Hui Qu, Pisong Li, Hongbo Qu, Xiaoyu Zhu, Zhongbin Han, Hongshen Chen","doi":"10.62347/JVGT3596","DOIUrl":"10.62347/JVGT3596","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a carbon nanoparticle-enhanced nomogram for predicting lateral lymph node (LLN) metastasis in patients with clinically node-negative (cN0) papillary thyroid carcinoma (PTC).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 421 cN0 PTC patients treated between 2014 and 2020. Patients were randomly divided into training (n=316) and internal validation (n=105) cohorts. Least absolute shrinkage and selection operator (LASSO) regression and Cox regression analyses were performed to identify predictive factors from clinical, ultrasonographic, and carbon nanoparticle tracing data. Model performance was evaluated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA).</p><p><strong>Results: </strong>Independent predictors identified included age (HR: 0.944, 95% CI: 0.908-0.982), tumor diameter ≥1 cm (HR: 0.221, 95% CI: 0.053-1.920), regular tumor morphology (HR: 0.090, 95% CI: 0.020-0.470), and the number of carbon nanoparticle-stained positive lateral lymph nodes (HR: 0.000, 95% CI: 0.000-0.231). The nomogram showed excellent discrimination, with an AUC of 0.911 in the training set and 0.916 in the validation set, and good calibration (Brier scores of 5.70 and 4.50, respectively). DCA confirmed the clinical utility of the model across a range of risk thresholds.</p><p><strong>Conclusion: </strong>This carbon nanoparticle-guided nomogram is a practical and highly accurate tool for intraoperative risk stratification of LLN metastasis in cN0 PTC patients. Integrating tracer-based lymph node assessment with conventional clinicopathological factors enhances predictive capability compared to existing methods, potentially reducing unnecessary neck dissections while ensuring appropriate management of high-risk cases. Multicenter validation and incorporation of molecular markers are important next steps toward clinical implementation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5625-5640"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of apoptosis and its potential as a therapeutic target in inflammatory bowel disease associated with colorectal cancer.","authors":"Chuxin Zhang, Francis Atim Akanyibah, Xiu Wang, Fei Mao, Anquan Shang","doi":"10.62347/NCFF5626","DOIUrl":"10.62347/NCFF5626","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is a significant global health issue characterized by a complex etiology and high rates of recurrence. IBD increases the risk of acquiring colorectal cancer (CRC). CRC, the third leading cause of cancer worldwide, is becoming increasingly prevalent each year. Treatments targeting IBD and associated CRC do not yield effective results. One of the cell death processes associated with IBD pathogenesis is apoptosis. Although apoptosis helps maintain the intestinal barrier of the gut, excessive apoptosis is linked to the development of IBD and contributes to the growth and progression of CRC. In IBD, pro-apoptotic molecules are elevated, while they decrease in CRC. Therefore, therapies that inhibit pro-apoptotic molecules in IBD and enhance apoptosis in CRC may help prevent IBD and the associated CRC. This article reviews the mechanisms of apoptosis and its involvement in IBD and CRC. It also examines possible therapies, including gene and combination therapies that target apoptosis molecules and their signaling pathways in IBD and CRC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 7","pages":"5718-5745"},"PeriodicalIF":1.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}