American journal of translational research最新文献

{"title":"Effects of transcutaneous electrical acupoint stimulation on body temperature, hemodynamic responses, and recovery in patients undergoing open spinal surgery.","authors":"Yang Liu, Guoyan Li, Xuexi Tang, Wenqian Tang, Xuan Luo, Yi Zhang","doi":"10.62347/ZVAO6278","DOIUrl":"10.62347/ZVAO6278","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) on intraoperative hypothermia, hemodynamic stability, stress responses, and postoperative recovery in patients undergoing open spinal surgery.</p><p><strong>Methods: </strong>Sixty-six patients scheduled for elective open spinal surgery under general anesthesia were randomly assigned to either the TEAS group (Group E) or the control group (Group C). TEAS was applied at Dazhui (GV14), unilateral Neiguan (PC6), Zusanli (ST36), and Taixi (KI3). Nasopharyngeal temperature, blood pressure (BP), heart rate (HR), cardiac output (CO), stroke volume variation (SVV), blood glucose (Glu), bispectral index (BIS), recovery time, incidence of postoperative shivering, incision infection, and deep vein thrombosis were recorded at six predefined time points: after entering the operating room (T0), during tracheal intubation (T1), at skin incision (T2), during pedicle screw insertion (T3), at the end of surgery (T4), and upon awakening (T5).</p><p><strong>Results: </strong>Six patients withdrew from the study, leaving 30 patients in each group for analysis. Compared with Group C, patients in Group E had significantly higher nasopharyngeal temperatures at T3-T5. Recovery time was significantly shorter, and the incidence of postoperative shivering was significantly lower in Group E. Heart rate was significantly lower in Group E at T2, whereas cardiac output was significantly higher at T3. Blood glucose levels were significantly lower at T2-T5, and BIS values were significantly higher at T5 in Group E. No significant differences were observed in postoperative incision infection or deep vein thrombosis between the two groups.</p><p><strong>Conclusion: </strong>TEAS effectively attenuated intraoperative hypothermia, reduced perioperative stress-induced hyperglycemia, improved hemodynamic stability, shortened recovery from general anesthesia, and decreased postoperative shivering in patients undergoing open spinal surgery. These findings suggest that TEAS is a safe and promising adjunctive strategy for perioperative management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"6447-6457"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edoxaban plus aspirin de-escalation strategy versus continuous dual antithrombotic therapy in the perioperative period for patients with atrial fibrillation undergoing carotid artery stenting: a retrospective cohort study.","authors":"Mintao Li, Shiying Dong, Shaohui Yu, Bo Wang, Xuefeng Zhang, Chao Ma, Fenghuang Sun, Rongcai Jiang","doi":"10.62347/KDDU9091","DOIUrl":"10.62347/KDDU9091","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare the safety and efficacy of an edoxaban-based, time-limited dual antithrombotic therapy followed by a de-escalation strategy versus a continuous dual antithrombotic strategy in patients with atrial fibrillation (AF) undergoing carotid artery stenting (CAS).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 120 patients with CAS and AF who underwent surgery at Guizhou Panjiang Investment Holding (Group) Co., Ltd. General Hospital from June 2023 to December 2024 were retrospectively enrolled. According to the perioperative antithrombotic regimen, patients were divided into a de-escalation group (n=56) and a dual therapy group (n=64). Patients in the de-escalation group received edoxaban (standard dose) combined with aspirin (100 mg/d) preoperatively and during the first 6 months postoperatively, after which aspirin was discontinued and edoxaban monotherapy was continued from 6 to 12 months postoperatively. Patients in the dual therapy group received continuous treatment with edoxaban plus aspirin throughout the 12-month follow-up period. Platelet count, C-reactive protein (CRP), D-dimer, fibrinogen, and coagulation parameters, including prothrombin time (PT), thrombin time (TT), and activated partial thromboplastin time (APTT), were compared at 1, 6, and 12 months postoperatively. Bleeding events, embolic events, adverse reactions, carotid artery restenosis, stent thrombosis, health-related quality of life (EQ-5D-5L), and treatment adherence were recorded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Baseline characteristics were comparable between the two groups. After treatment, platelet count, CRP, D-dimer, and fibrinogen levels significantly decreased, whereas PT, TT, and APTT were significantly prolonged in both groups, with no significant intergroup differences. There was no significant difference in the incidence of vascular restenosis or stent thrombosis between the two groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05). At 12 months postoperatively, the de-escalation group had a significantly lower incidence of bleeding events than the dual therapy group (8.93% vs. 23.44%, &lt;i&gt;P&lt;/i&gt;=0.033), whereas the incidence of embolic events was comparable between groups (14.29% vs. 9.38%, &lt;i&gt;P&lt;/i&gt;=0.403). The incidence of bleeding events during the 6-12-month postoperative period was significantly lower in the de-escalation group. Subgroup analyses stratified by CHA&lt;sub&gt;2&lt;/sub&gt;DS&lt;sub&gt;2&lt;/sub&gt;-VASc score and HAS-BLED score showed consistently lower bleeding rates in the de-escalation group, with no significant increase in embolism events. At 12 months, the de-escalation group showed significantly higher EQ-5D utility index and VAS scores, higher overall medication adherence (87.50% vs. 73.43%, &lt;i&gt;P&lt;/i&gt;=0.035), and a lower rate of permanent treatment discontinuation due to adverse reactions (3.57% vs. 14.06%, &lt;i&gt;P&lt;/i&gt;=0.047).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In patients with AF undergoing CAS, an edoxaban-based de-escalation strategy involving conversion to m","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"6431-6446"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and clinical significance of serum C-reactive protein and blood lactate levels in elderly patients with chronic obstructive pulmonary disease complicated by acute lower respiratory tract infection.","authors":"Jing Zou, Dingfang Pi, Fei Peng, Guanghai Ji, Lei Yan, Jinyong Li, Yanxia Zhang","doi":"10.62347/KJWO5930","DOIUrl":"10.62347/KJWO5930","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate serum C-reactive protein (CRP) and blood lactate levels in elderly patients with Chronic Obstructive Pulmonary Disease (COPD) complicated by acute lower respiratory tract infection (ALRTI).</p><p><strong>Methods: </strong>A total of 265 elderly COPD patients (age ≥ 65 years) were retrospectively analyzed. According to the presence of ALRTI, patients were divided into an ALRTI group (n = 160) and a non-ALRTI group (n = 105). Serum CRP and blood lactate levels were measured within 24 hours of admission.</p><p><strong>Results: </strong>Compared with the non-ALRTI group, the serum CRP and lactate levels were significantly higher in the ALRTI group (both P < 0.01). Elevated CRP (OR = 3.22) and blood lactate (OR = 2.78) were independent risk factors for ALRTI. Both markers were positively correlated with Confusion, Urea, Respiratory rate, Blood pressure, Age ≥ 65 years (CURB-65) score (r = 0.452 and r = 0.387, both P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for the combination of CRP and lactate in predicting intensive care unit (ICU) admission was 0.835 [95% confidence interval (CI): 0.782-0.888], which was superior to either marker alone.</p><p><strong>Conclusion: </strong>Serum CRP and lactate levels are significantly elevated in elderly COPD patients complicated with ALRTI and are associated with disease severity. Their combined detection may improve the identification of high-risk patients and prediction of ICU admission.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"6421-6430"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality combined with biofeedback improves sleep quality and daytime function in patients with chronic insomnia.","authors":"Xiaofeng Xu, Xiaomin Kou, Jianying Yu","doi":"10.62347/XKYF7341","DOIUrl":"10.62347/XKYF7341","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of virtual reality (VR) combined with biofeedback on sleep quality and daytime function in patients with chronic insomnia.</p><p><strong>Methods: </strong>Data from 83 patients with chronic insomnia admitted to the sleep department of our hospital were retrospectively analyzed and divided into a control group and an observation group according to the treatment method. The control group received routine biofeedback therapy, and the observation group received VR combined with biofeedback therapy. The Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Multidimensional Fatigue Scale (MFI) and Daytime Function Scale (DFSS) were compared between the two groups before and after treatment, and the changes of sleep latency, total sleep time and awakening times in polysomnography (PSG) were analyzed.</p><p><strong>Results: </strong>After the above treatment, the PSQI and ISI scores of the observation group were significantly lower than those of the control group (P < 0.01). PSG showed that the sleep latency was shortened, the total sleep time was prolonged, and the number of awakenings was reduced (P < 0.05). In addition, in terms of daytime function, the MFI fatigue score of the observation group decreased and the DFSS score increased, and the differences were statistically significant (P < 0.05). Finally, after 1 month of follow-up, there was no significant difference in the incidence of adverse reactions between the two groups (P=0.071).</p><p><strong>Conclusion: </strong>VR combined with biofeedback can effectively improve the sleep quality of patients with chronic insomnia, reduce nocturnal awakening, and improve daytime functional status, without increasing the incidence of adverse reactions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"6044-6054"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved cardiac function and quality of life with initial macitentan-tadalafil combination therapy compared to tadalafil alone in pulmonary arterial hypertension.","authors":"Yaogui Chen, Yunxing Kuang, Qiang Zhao","doi":"10.62347/YZUE2441","DOIUrl":"10.62347/YZUE2441","url":null,"abstract":"<p><strong>Objectives: </strong>Pulmonary arterial hypertension (PAH) is a progressive disease leading to right ventricular failure. The purpose of this study was to evaluate the effects of macitentan combined with tadalafil versus tadalafil monotherapy on cardiac function and quality of life (QOL) in PAH patients.</p><p><strong>Methods: </strong>This retrospective analysis involved patients identified with PAH who commenced regular therapy between April 2024 and April 2025. Participants were divided into two groups according to their treatment regimen: tadalafil monotherapy (TM) and macitentan combined with tadalafil (MCT). Hemodynamic values, laboratory biomarkers, exercise capacity, and patient-reported outcomes were assessed at baseline and after 6 months of treatment.</p><p><strong>Results: </strong>In total, 217 patients were analyzed (TM group: 114; MCT group: 103). After 6 months, the MCT group demonstrated significantly greater improvements in mean pulmonary arterial pressure (38.73 vs. 40.31 mmHg, P=0.029), cardiac index (2.93 vs. 2.61 L/min/m², P<0.001), N-terminal pro-B-type natriuretic peptide (997.14 vs. 1058.20 fmol·ml^-1, P=0.034) and pulmonary vascular resistance (685.35 vs. 736.83 dyn·sec/cm⁵, P=0.001) compared to the TM group. The MCT group also showed a longer 6-minute walk distance (422.27 vs. 387.94 m, P=0.013) and lower Pulmonary Arterial Hypertension Symptoms and Impact Questionnaire symptom scores (0.84 vs. 0.95, P<0.001). Safety profiles were similar between groups (all P>0.05).</p><p><strong>Conclusions: </strong>Initial combination therapy with macitentan and tadalafil provides superior hemodynamic, functional, and QOL benefits compared to tadalafil monotherapy in patients with PAH.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"5765-5775"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapidly progressive air leak syndrome after uneventful extubation in a pediatric patient: a case report.","authors":"Hyeon Tae Kim, Joo Yong Lee","doi":"10.62347/CYNQ4622","DOIUrl":"10.62347/CYNQ4622","url":null,"abstract":"<p><strong>Background: </strong>Air leak syndrome following uneventful extubation is rare in pediatric patients undergoing nonthoracic surgery; however, it can lead to rapid airway compromise and respiratory failure.</p><p><strong>Case presentation: </strong>A previously healthy 8-year-old girl developed rapidly progressive generalized subcutaneous emphysema and dyspnea shortly after extubation following surgery for a right radial fracture. Intraoperative intubation was uneventful, the peak airway pressure remained within normal limits, and extubation proceeded with no coughing or bucking. After transfer to the ward, the oxygen saturation declined to 40%. Manual ventilation through a supraglottic airway device was associated with high resistance and air leakage. On arrival at the emergency department, severe cervicofacial swelling from subcutaneous emphysema precluded videolaryngoscopic intubation. Endotracheal intubation was eventually achieved with a Cormack-Lehane grade IV view. Imaging revealed extensive subcutaneous emphysema, pneumomediastinum, and bilateral pneumothorax. Needle decompression and bilateral chest tube insertion were conducted immediately, followed by mechanical ventilation in the intensive care unit. Bronchoscopy revealed no definite tracheobronchial injuries. The patient recovered without complications.</p><p><strong>Conclusion: </strong>Rapidly progressive air leak syndrome should be considered in children who develop neck swelling or unexplained respiratory distress shortly after extubation. Repeated forceful ventilation should be avoided when ventilation is ineffective and airway control should not be delayed.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"5829-5832"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacubitril/valsartan plus dapagliflozin improves cardiac function and reduces MACE and rehospitalization in hFrEF: a retrospective study.","authors":"Nimin Lu, Jinzhao Li, Tianzhu Li","doi":"10.62347/NEDG7038","DOIUrl":"10.62347/NEDG7038","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of sacubitril/valsartan combined with dapagliflozin in heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>A retrospective study included 400 HFrEF patients (control group: sacubitril valsartan, n=200; observation group: add dapagliflozin, n=200) treated for 6 months. Cardiac function, NT-proBNP, 6MWT, MACE, readmission rate, and adverse reactions were compared.</p><p><strong>Results: </strong>After treatment, LVEF increased in both groups (control: 32.5 ± 5.6% to 38.6 ± 6.2%; observation: 32.8 ± 5.4% to 42.3 ± 6.5%, P<0.05), with greater improvement observed in observation group. LVEDD, LVESD, and NT-proBNP decreased, while 6MWT increased in both groups (all P<0.05), with superior changes in observation group. Readmission rate (8.5% vs. 16.0%, P=0.022) and MACE (6.0% vs. 9.5%, P=0.040) were significantly lower in observation group. No significant differences in adverse reactions between groups (all P>0.05).</p><p><strong>Conclusion: </strong>Sacubitril valsartan combined with dapagliflozin improves cardiac function, reduces NT-proBNP, enhances exercise tolerance, and lowers readmission and MACE rates without increasing adverse reactions, offering better clinical net benefit than sacubitril valsartan alone.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"5988-5999"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A risk prediction model for metachronous peritoneal metastasis after radical gastrectomy in gastric cancer based on peripheral blood inflammatory markers and tumor pathological features.","authors":"Li Dong, Ruihao Zhang, Chenchang Xu, Lei Chen","doi":"10.62347/BVUX7223","DOIUrl":"10.62347/BVUX7223","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a prognostic scoring system for metachronous peritoneal dissemination (MPM) in gastric cancer patients following radical gastrectomy, based on preoperative peripheral blood inflammatory markers and postoperative tumor histological features.</p><p><strong>Methodology: </strong>A total of 522 gastric cancer patients who underwent radical gastrectomy were retrospectively analyzed, including 364 patients without MPM and 158 patients with MPM. Peripheral blood samples were collected within 7 days before surgery to measure neutrophil and lymphocyte counts, platelets, C-reactive protein (CRP), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and CA125. Four inflammatory indices were calculated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Histopathological features of the excised tissue were assessed postoperatively.</p><p><strong>Result: </strong>Compared with the non-MPM group, patients in the MPM group exhibited significantly larger tumors, a higher prevalence of diffuse-type Lauren patterns, poorly differentiated histology, deeper tumor invasion, more frequent lymph node metastasis, and elevated rates of perineural and lymphovascular infiltration (all P < 0.05). Neutrophil count, platelet count, CRP, NLR, PLR, SII, SIRI, CEA, CA19-9 and CA125 were all increased, whereas lymphocyte counts were reduced in the MPM group (all P < 0.05). Multivariate logistic regression analysis identified tumor size (OR=1.475), depth of invasion (OR=2.602), lymph node metastasis (OR=3.536), NLR (OR=2.457), PLR (OR=1.009), CA19-9 (OR=1.079), and CA125 (OR=1.156) as independent risk factors for MPM. A combined predictive model incorporating these seven parameters demonstrated an area under the receiver operating characteristic curve (AUC) of 0.952.</p><p><strong>Conclusion: </strong>A prognostic model integrating preoperative peripheral blood inflammatory indices and postoperative tumor histopathology can accurately predict the risk of metachronous peritoneal metastases in gastric cancer patients after radical gastrectomy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"5650-5663"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum HMGB1 and CA19-9 are independently associated with pulmonary cavity formation in patients with non-tuberculous mycobacterial pulmonary disease.","authors":"Yingying Zhang, Yanping Jiang","doi":"10.62347/WHMF5727","DOIUrl":"10.62347/WHMF5727","url":null,"abstract":"<p><strong>Objectives: </strong>This work aimed to investigate the changes in serum inflammatory factors (IFs) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) and to analyze their correlation with the presence of lung cavities.</p><p><strong>Methods: </strong>A retrospective study was conducted on 80 NTM-PD patients and 80 non-active pulmonary tuberculosis (Non-ATB) controls. Clinical characteristics, NTM species distribution, and chest CT findings were analyzed. Serum levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), interleukin-1 (IL-1), IL-6, IL-8, high mobility group box protein 1 (HMGB1), Cystatin C (Cys C), and carbohydrate antigen 19-9 (CA 19-9) were measured by ELISA. Correlations between IFs and cavitation were assessed using Spearman's test.</p><p><strong>Results: </strong>Cavitation on CT was present in 31.2% of NTM-PD patients. Compared to Non-ATB controls, NTM-PD patients showed significantly higher levels of CRP, TNF-α, IL-6, HMGB1, Cys C, and CA19-9 (all <i>P</i><0.05). Among NTM-PD patients, those with cavitation had significantly higher CRP, IL-6, IL-8, HMGB1, Cys C, and CA19-9 than those without cavitation (all <i>P</i><0.05). Spearman analysis showed that cavitation positively correlated with CRP (r=0.284, <i>P</i><0.05), IL-6 (r=0.195), IL-8 (r=0.189), HMGB1 (r=0.328), Cys C (r=0.272), and CA19-9 (r=0.312) (all <i>P</i><0.05). ROC analysis revealed that the combination of HMGB1, CA19-9, and CRP yielded an AUC of 0.789 (95% CI: 0.672-0.906), with 76.0% sensitivity and 78.2% specificity. Multivariate logistic regression identified elevated HMGB1 (OR=1.142, 95% CI: 1.043-1.250, <i>P</i>=0.004), elevated CA19-9 (OR=1.067, 95% CI: 1.018-1.118, <i>P</i>=0.007), and coexisting bronchiectasis (OR=2.681, 95% CI: 1.076-6.684, <i>P</i>=0.034) as independent risk factors for cavitation.</p><p><strong>Conclusions: </strong>Serum HMGB1 and CA19-9 were independently associated with lung cavitation in NTM-PD patients and, together with CRP, may serve as non-invasive biomarkers for disease severity.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"5913-5925"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaoyao Gancao decoction for neuropathic pain: a systematic review and meta-analysis of postherpetic neuralgia.","authors":"Jinfeng Zhao, Fengyun Wang, Fang Wang, Ling Ma","doi":"10.62347/AEVA1650","DOIUrl":"10.62347/AEVA1650","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the efficacy and safety of Shaoyao Gancao Decoction (SGD) for neuropathic pain (NP), with a focused analysis on postherpetic neuralgia (PHN), the most evidence-rich subtype, and to provide evidence for clinical decision-making.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) on SGD for PHN were retrieved from databases up to March 2026. Two reviewers independently screened literature, extracted data, and assessed risk of bias using the Cochrane tool. Meta-analyses were performed using RevMan 5.3, and effect sizes were expressed as odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Fifteen RCTs involving 1,188 patients with PHN (594 per group) were included. Compared with conventional Western medicine alone, the addition of SGD significantly improved the overall response rate (OR=5.42, 95% CI: 3.40-8.64, P<0.0001), reduced Visual Analogue Scale (VAS) pain score (MD=-1.33, 95% CI: -1.68 to -0.99, P<0.0001), improved Pittsburgh Sleep Quality Index (PSQI) score (MD=-2.23, 95% CI: -2.85 to -1.62, P<0.0001), and lowered the incidence of adverse events (OR=0.34, 95% CI: 0.21-0.56, P<0.0001). Subgroup analyses by treatment duration (14 and 28 days) showed consistent analgesic effects and overall efficacy. Pain Rating Index (PRI) and Present Pain Intensity (PPI) scores were also significantly improved in the SGD group (both P<0.0001). Although high heterogeneity was observed in VAS (I²=97%), subgroup and sensitivity analyses suggested that the pooled results remained robust. Given that PHN represents a common NP subtype, SGD may have potential therapeutic value for broader NP conditions.</p><p><strong>Conclusion: </strong>Current evidence supports SGD as an adjunctive therapy for PHN, with good efficacy and safety. Its potential value for other NP types (such as diabetic peripheral neuropathy, chemotherapy-induced neuropathy) warrants further research.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 7","pages":"6055-6068"},"PeriodicalIF":1.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}