American journal of translational research最新文献

{"title":"Enhanced analgesic efficacy and reduced stress response with ropivacaine transversus abdominis plane block in laparoscopic myomectomy.","authors":"Li Yang, Peng Huang, Yi Sai, Dongxia Tan, Yin Huang, Ying Chen","doi":"10.62347/REUS7920","DOIUrl":"10.62347/REUS7920","url":null,"abstract":"<p><strong>Background: </strong>Managing postoperative pain and stress response was critical in laparoscopic myomectomy, a procedure for uterine fibroids. Ropivacaine transversus abdominis plane block (RTAPB) may offer enhanced analgesic efficacy and reduced stress responses compared to traditional analgesia.</p><p><strong>Methods: </strong>This retrospective analysis examined 217 patients undergoing laparoscopic myomectomy at Hankou Hospital of Wuhan from June 2020 to September 2023. Patients were divided into routine analgesia (CA, n = 105) and RTAPB (n = 112) groups. Pain levels were assessed using the Visual Analog Scale (VAS). Stress hormone levels (cortisol, norepinephrine, Interleukin-6), preoperative and postoperative recovery, sleep quality, hemodynamic stability, complications, and patient satisfaction were evaluated post-surgery.</p><p><strong>Results: </strong>The RTAPB group demonstrated significantly lower postoperative VAS pain scores at all measured intervals (<i>P</i> < 0.05). Stress hormones (postoperative cortisol, norepinephrine, and IL-6) were substantially lower in the RTAPB group compared to CA (<i>P</i> < 0.05), indicating reduced stress response. Intraoperative hemodynamic stability was improved with RTAPB, reflected in lower heart rate and mean arterial pressure (<i>P</i> < 0.05). Postoperative recovery and sleep quality were also better in the RTAPB group, as evidenced by higher QoR-40 and lower PSQI scores (<i>P</i> < 0.01). Although not statistically significant, RTAPB showed a trend toward fewer complications. Patient satisfaction, particularly with pain management, was significantly higher in the RTAPB group (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>RTAPB significantly enhances analgesic efficacy and moderates the physiological stress response in laparoscopic myomectomy patients compared to routine analgesia.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7303-7316"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heparan sulfate 6-O-sulfotransferase 2 promotes gastric cancer progression by modulating the TGF-β/smad2/3 pathway.","authors":"Shuai Wu, Changqin Xu, Weijia Sun, Qianqian Xu, Feifei Zhou, Ruzhen Jia, Hongwei Xu","doi":"10.62347/LWZR1836","DOIUrl":"10.62347/LWZR1836","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role of heparan sulfate 6-O-sulfotransferase 2 (HS6ST2) in gastric cancer (GC).</p><p><strong>Methods: </strong>HS6ST2 expression in GC and adjacent normal gastric mucosa was first detected via immunohistochemical (IHC) staining. The correlation between the expression level of HS6ST2 and clinicopathological parameters were observed. The protein expression of HS6ST2 in AGS, MKN45 and GES-1 cells was examined using Western blotting. The function of HS6ST2 in GC cells was explored via CCK-8, wound healing and Transwell assays. To elucidate the underlying molecular mechanisms, we detected whether HS6ST2 modulated the TGF-β/smad2/3 signaling pathway. Finally, we investigated the role of HS6ST2 in tumor growth in a nude mouse model.</p><p><strong>Results: </strong>The expression level of HS6ST2 in GC tissues was significantly higher than that in adjacent normal gastric mucosa and was positively correlated with tumor size. Compared with GES-1 cells, the expression level of HS6ST2 in AGS and MKN45 cells was significantly elevated. Silencing HS6ST2 impaired GC cell growth, mobility and epithelial-mesenchymal transition (EMT). On the other hand, HS6ST2 upregulation increased GC cell growth, migration and invasion, which was dramatically blocked by SB431542 treatment. Furthermore, mouse xenograft experiments demonstrated that HS6ST2 silencing inhibited tumor growth and EMT <i>in vivo</i>.</p><p><strong>Conclusion: </strong>HS6ST2 promotes GC progression through the modulation of the TGF-β/smad2/3 pathway.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7924-7936"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelve Shugan Lidan Granules from traditional Chinese medicine can improve liver function in patients with postoperative hepatolithiasis by inhibiting the Hippo signaling pathway.","authors":"Lixiang Li, Xiaoyong Niu, Wanzong Zhang, Ziyu Wang, Shengming Zhang, Qi Zhang, Wei Qi, Wenshan Jing, Gaobin Hu, Long Huang, Ziyi Li, Qiyu Feng, Hui Peng, Qingsheng Yu","doi":"10.62347/VXHU6738","DOIUrl":"10.62347/VXHU6738","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatolithiasis (HL) is a complex liver and biliary disorder characterized by high rates of recurrence. This study aimed to evaluate the efficacy of Twelve Shugan Lidan Granules (TSLG), a compound herbal traditional Chinese formulation, in the treatment of HL, as well as to investigate its underlying mechanism.</p><p><strong>Methods: </strong>A retrospective analysis was conducted involving 157 patients diagnosed with HL, who were divided into two groups: the control group and the research group. In the control group, no treatment was given postoperatively, while in the research group, TSLG was orally administered three times a day postoperatively for two months. Both groups were followed up by telephone at 1 month, 2 months, and 3 months postoperatively. Liver function indicators were measured before and after surgery, and miRNA expression profiling was analyzed using high-throughput sequencing (HTS). Additionally, the expression levels of related proteins were assessed through western blots.</p><p><strong>Results: </strong>Postoperative liver function indicators were significantly lower in the research group compared to the control group (P < 0.05). Additionally, 64 miRNAs were differentially expressed in HL patients. Further analysis of 64 miRNAs revealed their abnormal targeting of the Hippo signaling pathway. Further experimental results indicate that TAZ protein expression is elevated in HL patients, reflecting abnormal activation of the Hippo signaling pathway in these patients. TSLG treatment significantly reduced the expression of YAP, TAZ, and SREBP-2 proteins, while increasing the expression of p-YAP and p-TAZ proteins (all P < 0.05). Furthermore, TSLG inhibited the Extracellular Acidification Rate (ECAR) in LPS-induced WRL68 cells.</p><p><strong>Conclusion: </strong>TSLG effectively improved postoperative liver function by downregulating sterol regulatory element-binding protein-2 (SREBP-2) and inhibiting the Hippo signaling pathway.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"7186-7199"},"PeriodicalIF":1.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic materials science reconsidered.","authors":"Futian Dong","doi":"10.62347/WKWE7595","DOIUrl":"10.62347/WKWE7595","url":null,"abstract":"<p><p>Bioinformatic materials science integrates medical science, materials science, informatics, and other disciplines, aiming to maintain the balance of tissues and organs in the human body. This paper explores the relationship between structural information and the structures synthesized through regulated gene expression. Specifically, it describes the transformation of information into substances via biological structural systems, using mathematical formulas to develop bioinformatic materials. These materials have applications in medical treatments, functional foods for preventive healthcare, and cosmetic products for health maintenance. Notably, bioinformatic materials have been applied in treating acromegaly, a rare and life-threatening disease of unknown etiology, and have improved the neurofilament light chain (NFL) index and typical symptoms of Amyotrophic Lateral Sclerosis (ALS). In summary, bioinformatic materials science holds potential for enhancing human health and contributing to advances in medicine.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"7200-7204"},"PeriodicalIF":1.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Transplantation of bone marrow-derived mesenchymal stem cells rescues partially rachitic phenotypes induced by 1,25-Dihydroxyvitamin D deficiency in mice.","authors":"Zengli Zhang, Shaomeng Yin, Xian Xue, Ji Ji, Jian Tong, David Goltzman, Dengshun Miao","doi":"10.62347/OLIL8708","DOIUrl":"10.62347/OLIL8708","url":null,"abstract":"<p><p>[This corrects the article on p. 4382 in vol. 8, PMID: 27830022.].</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"7205-7207"},"PeriodicalIF":1.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of body mass index on breast cancer prognosis: a focus on ER/PR status and subtype-specific recurrence risk.","authors":"Qinyan Shen, Liangying Zhao, Minjun Lu","doi":"10.62347/WJIQ1560","DOIUrl":"10.62347/WJIQ1560","url":null,"abstract":"<p><strong>Objective: </strong>To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.</p><p><strong>Methods: </strong>A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.</p><p><strong>Results: </strong>Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.</p><p><strong>Conclusions: </strong>Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for patients with ER-positive/PR-positive tumors.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6467-6476"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial harmony in female reproductive health: exploring the impact of intestinal flora on ovarian function and disease pathogenesis.","authors":"Xiaoyan Luo, Yichuan Guo, Liangzhi Xu","doi":"10.62347/GDNO7274","DOIUrl":"10.62347/GDNO7274","url":null,"abstract":"<p><p>The intestinal microbiota is vast in type and quantity and it plays a critical role in regulating various physiological functions in the host, including intestinal function, immune response and energy metabolism. Existing research shows that intestinal flora is associated with various hormones, cell cycles and ovarian function-related diseases in the female ovaries. Certain microorganisms within the intestinal flora can modulate the levels of hormones secreted by the ovary, such as estrogen and androgens. Furthermore, an imbalance in the gut microbiota can result in altered hormone levels in the host, potentially leading to related diseases. Studies have found that a variety of ovarian function-related diseases are closely related to intestinal flora, such as polycystic ovary syndrome (PCOS), ovarian insufficiency (POI), endometriosis (EMS) and ovarian cancer. Importantly, ovarian function-related diseases are notably difficult to diagnose early and often require prolonged treatment for effective management. The microbiota and its metabolites in patients with ovarian function-related diseases and cancers can serve as valuable biomarkers for early diagnosis, offering novel strategies for disease screening, treatment stratification, and prognosis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6274-6288"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.","authors":"Hang Shu, Xiaoyu Chen, Jie Zhao, Ping Li, Zhen Sun","doi":"10.62347/JRDP4018","DOIUrl":"10.62347/JRDP4018","url":null,"abstract":"<p><strong>Background: </strong>Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation and metastasis. Protein Inhibitor of Activated STAT (PIAS) family genes, comprising PIAS1, PIAS2, PIAS3, and PIAS4, are emerging as significant players in cancer biology due to their roles in SUMOylation, transcriptional regulation, and modulation of signal transduction pathways. This study provides a comprehensive analysis of PIAS family genes from a pan-cancer viewpoint.</p><p><strong>Methodology: </strong>Detailed in silico analyses using publicly available databases and in vitro analyses involving cell culture, gene knockdown, colony formation, and wound healing assays.</p><p><strong>Results: </strong>Expression analysis revealed consistent up-regulation of PIAS1, PIAS2, PIAS3, and PIAS4 genes in tumors compared to normal tissues. Univariate Cox regression analyses indicate that high PIAS gene expression correlates with worse overall survival in specific cancers, particularly kidney renal papillary cell carcinoma (KIRP) and liver hepatocellular carcinoma (LIHC). Kaplan-Meier plots further confirm that higher PIAS gene expression is significantly associated with reduced survival probabilities in these cancers. Genetic alteration analysis showed low mutation frequencies in PIAS genes, suggesting their role in cancer progression is likely due to expression regulation rather than genetic mutations. Correlations with immune subtypes, the tumor microenvironment (TME), and immune stimulatory genes highlight the differential expression of PIAS genes across immune landscapes in KIRP and LIHC. Gene enrichment analysis emphasizes the involvement of PIAS genes in crucial cellular processes, including SUMOylation and ubiquitin-mediated proteolysis. Finally, knockdown experiments in HCC-LM3 cells demonstrate that PIAS2 and PIAS3 promote tumor growth and metastasis, reinforcing their potential as therapeutic targets.</p><p><strong>Conclusion: </strong>This study revealed the multifaceted roles of PIAS genes in KIRP and LIHC biology and their potential as prognostic biomarkers and therapeutic targets.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6346-6364"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoledronic acid improves periodontal health, reduces serum inflammation, and enhances bone metabolism in postmenopausal osteoporosis complicated by periodontitis.","authors":"Ge Xu, Ying Guo, Wei Wang, Wan-Qiu Yu, Qian-Min Chen, Hong Wang","doi":"10.62347/GXEB5902","DOIUrl":"10.62347/GXEB5902","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of zoledronic acid (ZA) on periodontal indices, serum inflammatory markers, and bone metabolism in postmenopausal osteoporosis (PMO) patients with periodontitis (PD).</p><p><strong>Methods: </strong>A total of 113 PMO+PD cases were recruited between May 2021 and February 2024. Fifty-two cases in the control group received standard therapy, while 61 cases in the observation group were treated with ZA. Therapeutic efficacy, periodontal indices (attachment loss [AL], probing depth [PD], and gingival bleeding index [GBI]), serum inflammatory markers (interleukin-1β [IL-1β], tumor necrosis factor-α [TNF-α], and C-reactive protein [CRP]), bone metabolism markers (N-terminal midfragment of osteocalcin [N-MID], beta-CrossLaps [β-CTx], and human calcitonin [hCT]), safety (fever, constipation, muscle soreness), and bone mineral density (BMD) at the lumbar spine and proximal femur were analyzed. A multivariable binary logistic regression model was used to determine factors influencing therapeutic efficacy.</p><p><strong>Results: </strong>The observation group demonstrated significantly better therapeutic outcomes than the control group. Treatment type was identified as an independent factor influencing efficacy. In the observation group, AL, PD, GBI, IL-1β, TNF-α, CRP, N-MID, and β-CTX levels were significantly reduced post-intervention compared to pre-intervention levels and the control group (all P<0.05), with no significant inter-group differences in hCT levels or adverse event rates (both P>0.05). BMD in the lumbar spine and proximal femur improved significantly in the observation group compared to the control group (both P<0.05).</p><p><strong>Conclusions: </strong>ZA positively impacts periodontal health, reduces serum inflammation, and enhances bone metabolism in PMO patients with PD.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6519-6527"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative recurrence prediction model for atrial fibrillation: a meta-analysis.","authors":"Chaofeng Chen, Yanyan Guo","doi":"10.62347/IJEP7120","DOIUrl":"10.62347/IJEP7120","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate a recurrence risk prediction model for patients with Atrial Fibrillation (AF) following ablation, and to provide a reference for the model establishment and optimization.</p><p><strong>Methods: </strong>Literature retrieval was conducted in databases including PubMed, Cochrane Library, EMbase, and Web of Science to collect studies on recurrence risk prediction models for AF patients following ablation. Study quality was assessed using Prediction Model Risk of Bias Assessment Tool, and a meta-analysis was performed using MedCalc statistical software.</p><p><strong>Results: </strong>A total of 17 studies were included, with 4 of high risk of bias, 9 of unknown risk of bias, and 4 of low risk of bias. Across all studies, forest plots and logistic regression models were the most used prediction models. The area under the receiver operating characteristic curve (AUC) values of the prediction models ranged from 0.667 to 0.920, with a median AUC of 0.852. Through the calculation of the weighted summary of the AUC, the meta-analysis yielded a total AUC of 0.815 (0.780-0.850), indicating that the prediction models have good overall discrimination for the risk of recurrence in AF patients after ablation. After excluding studies with extreme AUC values, the adjusted AUC was 0.817 (0.786-0.849), suggesting that these extreme values did not significantly affect the overall combined results. Further subgroup analysis revealed that factors such as study design, follow-up time, sample size, and data set partitioning may significantly influence model performance and heterogeneity. Meta-analysis of predictive factors referenced in at least three studies showed that gender (<i>OR</i> = 0.862), atrial fibrillation type (<i>OR</i> = 0.660), and left atrial diameter (<i>OR</i> = 0.094) were predictive factors for postoperative recurrence in atrial fibrillation patients (<i>P</i> < 0.05). Results of Egger's test and Begg's test did not find evidence of publication bias in the studies.</p><p><strong>Conclusion: </strong>Current predictive models can be used as clinical decision support tools, but due to certain heterogeneity and risk of bias, they are recommended to be used cautiously in clinical practice and combined with other clinical information for comprehensive judgments.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6208-6224"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}