American journal of translational research最新文献

{"title":"Combination of keloid core excision and triamcinolone acetonide local injection shows significant clinical efficacy in treating auricular keloid.","authors":"An-Fang Zou, Tian Liu, Qin Li","doi":"10.62347/XCLA2307","DOIUrl":"10.62347/XCLA2307","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical efficacy of keloid core excision combined with triamcinolone acetonide (TA) local injection for the treatment of auricular keloids.</p><p><strong>Methods: </strong>From May 2019 to November 2021, 86 patients with auricular keloid who met the inclusion criteria were enrolled. Based on treatment modality, they were divided into two groups: a research group (n=43) receiving keloid core excision combined with TA local injection and a control group (n=43) undergoing keloid core excision alone. The clinical efficacy, postoperative adverse reactions, Vancouver Scar Scale (VSS) score 12-Item Pruritus Severity Scale (12-PSS) score, sleep quality, serological indicators, Self-Rating Anxiety Scale (SAS) score, Self-Rating Depression Scale (SDS) score, Short-Form 36-Item Health Survey (SF-36) scores, recurrence rate, and treatment satisfaction were compared between the two groups.</p><p><strong>Results: </strong>The research group showed superior overall clinical efficacy, higher SF-36 scores, fewer total adverse reactions, and better sleep quality compared to the control group. Additionally, the research group had lower VSS, 12-PSS, SAS, and SDS scores, more significant reductions in serological indicators, and a reduced recurrence rate.</p><p><strong>Conclusions: </strong>Keloid core excision combined with TA local injection was more effective than keloid core excision alone in treating auricular keloids, with significantly better clinical efficacy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3152-3161"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a predictive model for the risk of postpartum hemorrhage in women with advanced maternal age undergoing natural childbirth.","authors":"Dan Ren, Zhiying Yang, Xiao Su, Yunyun Lai","doi":"10.62347/EMNY9955","DOIUrl":"10.62347/EMNY9955","url":null,"abstract":"<p><strong>Objective: </strong>To identify the risk factors of postpartum hemorrhage (PPH) in women of advanced maternal age (AMA) undergoing natural childbirth and to develop a nomogram model for PPH risk prediction in this population.</p><p><strong>Methods: </strong>This study retrospectively collected data from 220 AMA women who had a natural childbirth at the Third Affiliated Hospital of Chengdu Medical College, Chengdu Pidu District People's Hospital between March 2020 and May 2023, forming the training cohort. The cohort was categorized into the PPH group and the non-PPH group based on the occurrence of PPH. Clinical data were compared between the two groups. Univariate and multivariate logistic analyses were employed to identify the factors associated with PPH. A predictive model for the risk of PPH in AMA women was developed, and its predictive accuracy was assessed using calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). Additionally, clinical data from 110 AMA women who had a natural childbirth at our hospital between June 2023 and August 2024 were collected, forming the validation cohort.</p><p><strong>Results: </strong>The overall incidence of PPH was 17.58% (58/330), including 39 from the training cohort, and 19 from the validation cohort. Univariate logistic analysis revealed that age, placenta previa, hypertensive disorder of pregnancy (HDP), fetal macrosomia, uterine atony, and scarred uterus were significant risk factors for PPH in AMA women (all <i>P</i> < 0.05). Multivariate logistic model identified age, placenta previa, HDP, uterine atony, and scarred uterus as independent risk factors for PPH in AMA women (all <i>P</i> < 0.05). Based on these independent risk factors, a nomogram model for predicting PPH in AMA women was developed, demonstrating an area under the ROC curve (AUC) of 0.841 (95% CI: 0.773-0.908) in the training cohort and 0.868 (95% CI: 0.767-0.969) in the validation cohort. The calibration curve analysis indicated that the model's predicted PPH risk in AMA population closely aligned with the actual outcomes, while DCA demonstrated model's significant clinical utility.</p><p><strong>Conclusion: </strong>The nomogram prediction model developed in this study effectively estimates the risk of PPH in AMA women, offering valuable clinical guidance.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2591-2603"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal biomechanical properties in myopic anisometropia measured by corneal visualization scheimpflug technology.","authors":"Hui Shao, Qing Zhu, Lina Zhang, Lifang Shen, Qiuju Zhou, Liyan Tang, Yiyu Meng","doi":"10.62347/EPRI9798","DOIUrl":"10.62347/EPRI9798","url":null,"abstract":"<p><strong>Objective: </strong>To explore corneal biomechanical properties in patients with myopic anisometropia using a corneal visualization scheimpflug technology (Corvis ST).</p><p><strong>Methods: </strong>We examined 102 eyes from 51 adults with anisometropia (minimum spherical equivalent (SE) of 2.50 D). Patients were classified into two groups based on their SE: high myopia (SE ≥ -6.00 D) (n=52 eyes) and non-high myopia group (SE ≤ -6.00 D) (n=50 eyes). Corneal biomechanical and ocular biometric parameters were measured.</p><p><strong>Results: </strong>In the high myopia group, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT) were significantly higher compared to the non-high myopia group (all P < 0.001). The second applanation time (A2-time), length of flattened cornea at second applanation (A2-length), and time to highest concavity (HC-time) were shorter in the high myopia group (all P < 0.001). The high myopia group also exhibited lower elasticity and rigidity indices, higher EAI (all P < 0.001), and greater central/mid-peripheral deformation amplitudes (both P < 0.001), with minimal peripheral differences (P=0.074).</p><p><strong>Conclusion: </strong>CorVis ST provides a reliable method for measuring corneal biomechanical properties. In anisometropia, eyes with higher myopia show higher deformation amplitude, faster A2-velocity, shorter A2-time and HC-time, and reduced A2-length.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2817-2825"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic efficiency of peripheral tumor serum biomarkers in lung cancer and their correlation with clinicopathological features.","authors":"Hongjuan Lv, Ping Luo, Jiahe Wang, Chen Chen, Yuanyuan Guo, Yanhong Li","doi":"10.62347/TAEI9443","DOIUrl":"10.62347/TAEI9443","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical value of serum tumor markers - carcinoembryonic antigen (CEA), endothelial cell-specific molecule-1 (ESM-1), neuron-specific enolase (NSE), and cytokeratin 19 fragment (CYFRA21-1) - in the diagnosis of lung cancer, and to evaluate the role of preoperative imaging in lung cancer diagnosis.</p><p><strong>Methods: </strong>A total of 56 lung cancer patients, diagnosed at The Fourth Hospital of Daqing City between January 2022 and December 2023, were included in the lung cancer group. Additionally, 69 patients with benign pulmonary tumors diagnosed during the same period were included in the benign tumor group. Preoperative peripheral serum levels of CEA, CYFRA21-1, NSE, and ESM-1 were compared between the two groups. The expression profiles of these biomarkers were further analyzed, focusing on their correlation with TNM staging, lymph node metastasis, and tumor differentiation. Receiver operating characteristic (ROC) curves were plotted to assess the diagnostic performance of these biomarkers. Imaging characteristics were also compared between the two groups to identify features indicative of lung cancer.</p><p><strong>Results: </strong>Serum levels of CYFRA21-1, CEA, ESM-1, and NSE were significantly higher in the lung cancer group compared to the benign tumor group (all P < 0.05). Pathological analysis revealed that these markers were notably associated with low to medium tumor differentiation, lymph node metastasis, and advanced stage (III-IV) (all P < 0.05). Additionally, small cell lung cancer patients exhibited higher positive rates of CYFRA21-1 and elevated levels of CEA, ESM-1, and NSE compared to non-small cell lung cancer patients. ROC curve analysis demonstrated AUC values of 0.878, 0.778, 0.773, and 0.654 for CYFRA21-1, CEA, ESM-1, and NSE, respectively. Imaging features, including spiculated margins, lobulation, pleural retraction, vascular convergence, vacuolar signs, and larger nodule size, were more prevalent in lung cancer patients and were identified as independent risk factors for lung cancer.</p><p><strong>Conclusion: </strong>Peripheral serum biomarkers, including CYFRA21-1, CEA, ESM-1, and NSE, demonstrate significant diagnostic potential for lung cancer. Furthermore, imaging characteristics provide valuable insights for distinguishing lung cancer, underscoring the clinical applicability of both diagnostic approaches.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2712-2720"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of early stepwise controlled decompression combined with mild hypothermia therapy on efficacy, cerebral edema volume, and serum biochemical indices in patients with severe hypertensive intracerebral hemorrhage.","authors":"Dawei Liu, Binbin Fu, Yixin Wang","doi":"10.62347/TRKY5505","DOIUrl":"10.62347/TRKY5505","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of early stepwise controlled decompression combined with mild hypothermia therapy (MHT) on clinical outcomes in patients with severe hypertensive intracerebral hemorrhage (sHICH).</p><p><strong>Methods: </strong>A total of 80 sHICH patients were included, with 32 cases in the control group receiving conventional craniotomy for hematoma evacuation and MHT, and 48 cases in the observation group undergoing early stepwise controlled decompression plus MHT. The two groups were compared in terms of treatment efficacy, hematoma clearance rate, prognosis, National Institutes of Health Stroke Scale (NIHSS) and Functional Ambulation Category (FAC) scores, complications, cerebral edema volume, and serum biochemical indices.</p><p><strong>Results: </strong>The observation group demonstrated significantly better efficacy, higher hematoma clearance rates, and improved clinical outcomes compared to the control group (all P<0.05). Postoperatively, the observation group had significantly lower NIHSS scores, reduced levels of neuron-specific enolase, central nervous system-specific protein, and malondialdehyde, as well as lower incidences of encephalocele, cerebral infarction, and delayed intracranial hematoma (all P<0.05). Additionally, cerebral edema volume was significantly reduced, while FAC scores were notably higher in the observation group (both P<0.05).</p><p><strong>Conclusion: </strong>Early stepwise controlled decompression combined with MHT is highly effective in the treatment of sHICH, leading to better neurological recovery, reduced cerebral edema, and improved biochemical profiles.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3162-3170"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the development of heart failure after PCI in patients with acute coronary syndrome: a meta-analysis.","authors":"Qian-Zhu Jiang, Qian Xu, Dong-Mei Wan, Ying Kong","doi":"10.62347/FPXH3010","DOIUrl":"10.62347/FPXH3010","url":null,"abstract":"<p><strong>Objective: </strong>To systematically analyze the factors associated with heart failure (HF) development after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>Relevant literature on risk factors for HF following PCI in ACS patients were retrieved from PubMed, Embase, The Cochrane Library, Web of Science, and Medline buildup to September 2024. Two independent investigators conducted literature screening, quality assessment, and data extraction based on inclusion and exclusion criteria. Meta-analysis was performed using Stata 12.0 software.</p><p><strong>Results: </strong>A total of 20 papers were included, comprising 45,578 patients of whom 4,345 ACS patients developed HF after PCI. Meta-analysis identified several predictors of post-PCI HF in ACS patients, including advanced age [odds ratio (OR) =1.04, 95% confidence intervals (CI): 1.03-1.06], female gender (OR=1.43, 95% CI: 1.18-1.72), history of hypertension (OR=1.54, 95% CI: 1.31-1.80), history of diabetes mellitus (OR=1.55, 95% CI: 1.39-1.72), previous myocardial infarction (OR=1.58, 95% CI: 1.11-2.23), anterior wall myocardial infarction (OR=2.22, 95% CI: 1.89-2.61), reduced left ventricular ejection fraction (LVEF) (OR=1.40, 95% CI: 1.21-1.62), elevated white blood cell count (OR=1.14, 95% CI: 1.07-1.22), atrial fibrillation [hazard ratio (HR) =2.14, 95% CI: 1.11-4.12], increased heart rate (OR=1.03, 95% CI: 1.02-1.04), elevated Pentraxin-3 (PTX3) levels (OR=2.67, 95% CI: 1.45-4.93), and decreased myocardial contractility (HR=1.18, 95% CI: 1.10-1.26). Notably, complete revascularization (HR=0.29, 95% CI: 0.10-0.86) was identified as a protective factor. Sensitivity analysis confirmed the robustness of these findings.</p><p><strong>Conclusions: </strong>Advanced age, female gender, history of hypertension and diabetes, previous myocardial infarction, anterior wall myocardial infarction, decreased LVEF at admission, increased white blood cell count, atrial fibrillation at admission, increased heart rate, elevated PTX3 levels, and impaired myocardial contractility were risk factors for HF development after PCI in ACS patients. Conversely, complete revascularization was associated with a lower risk of post-PCI HF.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2352-2375"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of transient receptor potential vanilloid type 1 (TRPV1) in colonic mucosa of patients with irritable bowel syndrome.","authors":"Boran Zhang","doi":"10.62347/CUXA2243","DOIUrl":"10.62347/CUXA2243","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression pattern of the transient potential vanilloid type 1 (TRPV1) in the colonic mucosa of patients with irritable bowel syndrome (IBS), its clinical manifestations, and possible pathways of action.</p><p><strong>Methods: </strong>This study included 80 IBS patients (IBS group) diagnosed at The Second Affiliated Hospital of Soochow University from 2013 to 2017, and 60 healthy examinees as controls (N group). All participants underwent colonoscopy and the results were normal. Colonic mucosal tissue was obtained through biopsy and paraffin sectioned for routine pathologic evaluation. Immunohistochemistry was used to detect the expression of TRPV1, and its correlation with IBS symptoms was analyzed.</p><p><strong>Results: </strong>The expression of TRPV1 in the IBS group (0.8, 0-8.4) was significantly higher than that of the control group (0.4, 0-1) (<i>P</i>=0.023). Spearman correlation analysis revealed a significant positive correlation between TRPV1 expression and IBS symptoms (<i>r</i>=0.772, <i>P</i><0.001). There were no significant differences in the expression of TRPV1 among IBS patients in each subgroup (Kruskal Wallis test, P=0.938>0.050). Comparing genders, the TRPV1 expression levels in male (1.0, 0-7.2) and female (0.8, 0-8.4) IBS patients were similar (<i>P</i>=0.871). Similarly, no significant gender differences were observed in symptom scores between male (4.0, 2-9.5) and female (3.75, 2.0-11.5) IBS patients. Additionally, there was no significant difference in TRPV1 expression in the mucosa of the ascending and descending colon among different subgroups (<i>P</i>>0.050).</p><p><strong>Conclusion: </strong>TRPV1 expression in the colonic mucosa of IBS patients is elevated and positively correlated with symptom severity. However, no significant differences were found in TRPV1 expression among patients with different IBS subtypes or between genders. The expression of TRPV1 was abnormal in the mucosa of ascending and descending colon, but the difference was not statistically significant.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2782-2789"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qingkailing injection induces pseudo-allergic reactions via the MRGPRX2 pathway.","authors":"Yu Zhang, Fang-Mei Liu, Cun-Yu Li, Xue-Jiao Leng, Yun-Feng Zheng, Guo-Ping Peng","doi":"10.62347/MFBU4210","DOIUrl":"https://doi.org/10.62347/MFBU4210","url":null,"abstract":"<p><strong>Objective: </strong>Qingkailing Injection (QKLI) is a traditional Chinese medicine injection mainly used for sedation, heat clearing, and other treatments. However, recent clinical studies have shown a risk of pseudo-allergic reactions. The purpose of this study is to elucidate the underlying mechanism of QKLI-induced mast cell degranulation in Laboratory of Allergic Diseases 2 (LAD2) and to validate QKLI-induced activation of guinea pig IgE-independent allergic responses.</p><p><strong>Methods: </strong>Levels of β-hexosaminidase (β-Hex), histamine (His), and complement pathway-related indicators in guinea pigs and LAD2 cells were assayed using the Enzyme-linked Immunosorbent Assay (ELISA). The release rates of β-Hex and His from LAD2 cells were measured using the o-phthalaldehyde (OPA) fluorimetric method. The antagonist for complement component 3a (C3a) receptors, SB290157 and siRNAs were used to inhibit the C3a pathway and the Mas-related G-protein-coupled receptor X2 (MRGPRX2) pathway. The MRGPRX2 pathway and its downstream proteins were detected by Western Blot (WB).</p><p><strong>Results: </strong>The results show that QKLI significantly increased levels of β-Hex, His, C3a, complement component 5a (C5a), and terminal complement complex C5b-9 (SC5b-9) in guinea pigs, while levels of interleukin 4 (IL-4), interleukin 13 (IL-13), and interleukin 6 (IL-6) were unaffected. The C3a receptor inhibitor SB290157 significantly reduced levels of β-Hex and His. In LAD2 cells, QKLI increased the release rates of β-Hex and His in a time-dependent manner and decreased the phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) proteins downstream of the MRGPRX2 pathway. The effective components of QKL, baicalin (BA) and geniposide (GE), individually enhance the allergic responses of LAD2 cells to some extent. However, the use of QKL is significantly superior to the individual use of its components.</p><p><strong>Conclusions: </strong>We found that QKLI induced pseudoanaphylaxis via an IgE-independent response in guinea pigs and through the MRGPRX2 pathway in human LAD2 cells. Among these, the main ingredients causing pseudoallergic reactions in QKLI were BA and GE. Our research contributes to a better understanding of the mechanisms underlying drug hypersensitivity reactions (DHRs).</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2178-2187"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of spine-pelvis parameters and age with lumbar paravertebral muscle degeneration in middle age and older adults.","authors":"Wei Xu, Ning Zhang, Jia Li, Xianzhong Meng","doi":"10.62347/VJEZ8472","DOIUrl":"https://doi.org/10.62347/VJEZ8472","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To analyze the correlation between spine-pelvis parameters, age and lumbar paravertebral muscle degeneration in middle-aged and older adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;This retrospective study involved 143 middle-aged and elderly patients with suspected lumbar paravertebral muscle degeneration treated at The Third Hospital of Hebei Medical University between January 2021 and June 2023. Based on confirmed diagnoses, patients were divided into a degenerative group (57 cases) and a non-degenerative group (86 cases). Clinical data were analyzed to explore the relationship between pelvic parameters, age, and lumbar paravertebral muscle degeneration. Univariate and multivariate logistic regression were used to identify risk factors, and Receiver Operating Characteristic (ROC) analysis was performed to evaluate the predictive value of these factors. Differences in areas under the curve (AUC) for clinical factors were assessed using the DeLong test.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result: &lt;/strong&gt;No significant differences were found between the two groups in clinical data, except for age (P&lt;0.05). Comparison of spine-pelvis parameters revealed that the pelvic tilt (PT) and pelvic incidence (PI) were significantly higher in the degenerative group than those in the non-degenerative group, while the sacral slope (SS) and lumbar lordosis (LL) were lower (all P&lt;0.05). Additionally, the CSA ratios between the third and fourth lumbar vertebrae (L3/4) and between the fourth and fifth lumbar vertebrae (L4/5) were found to be significantly lower in the degenerative group as opposed to those in the non-degenerative group (all P&lt;0.05). Kendall's analysis showed that age and spine-pelvis parameters (PT, PI) were positively correlated with lumbar paravertebral muscle degeneration (OR=0.733, 0.639, 0.695; P&lt;0.0001). In contrast, spine-pelvic parameters (SS, LL) were negatively correlated with degeneration (OR=-0.695, -0.698; P&lt;0.0001). Pearson's correlation analysis also revealed a positive correlation between age and spine-pelvic parameters (PT, PI) (r=0.826, 0.985, P&lt;0.001), and a negative correlation between age and spine-pelvic parameters (SS, LL) (r=-0.861, -0.942, P&lt;0.001). Additionally, spine-pelvic parameter PT was negatively correlated with CAS ratio of L3/4 disc levels (r=-0.412, P&lt;0.000). Logistic multivariate regression analysis identified age (OR=0.616, &lt;i&gt;P&lt;/i&gt;&lt;0.0001), PT (OR=0.827, &lt;i&gt;P&lt;/i&gt;&lt;0.0001), SS (OR=1.095, &lt;i&gt;P&lt;/i&gt;=0.004), LL (OR=1.148, &lt;i&gt;P&lt;/i&gt;=0.019), PI (OR=0.853, &lt;i&gt;P&lt;/i&gt;&lt;0.0001), CAS ratio of L3/4 (OR=1.977, &lt;i&gt;P&lt;/i&gt;=0.002) and CAS ratio of L4/5 (OR=1.739, P=0.009) levels as independent risk factors for lumbar paravertebral muscle degeneration (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). ROC results showed that the AUCs for age, PT, SS, LL, PI, L3/4, and L4/5 in predicting lumbar paravertebral muscle degeneration in middle-aged and elderly people were 0.949, 0.828, 0.642, 0.779, 0.850, 0.683, 0.677, respectively (all &lt;i&gt;P&lt;/i&gt;&lt;0.05).&lt;/p&gt;&lt;p&gt;&lt;stron","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1707-1717"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous injection of 0.5 μg/kg dexmedetomidine during plasma resection of tonsil adenoids can reduce the incidence of delirium and hemodynamics in children.","authors":"Bing Liang, Ru Wu, Yanfang Lou","doi":"10.62347/TWCY6801","DOIUrl":"https://doi.org/10.62347/TWCY6801","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of different doses of dexmedetomidine on delirium and hemodynamics after plasma resection of adenoids in children.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 80 children who underwent plasma adenoidectomy of tonsil at the Pediatric Hospital of Fudan University from January 2022 to December 2023. The patients were divided into normal saline group, 0.1 μg/kg dexmedetomidine group, and 0.5 μg/kg dexmedetomidine group according to the dose of dexmedetomidine injected intravenously. Hemodynamic changes, modified Yale Preoperative Anxiety Scale (mYPAS-SF) scores, pharyngeal pain (at rest and during swallowing), coagulation function, and postoperative adverse reactions were compared at T0, 10 min after dexmedetomidine pumping (T1), extubation (T2), recovery (T3), 2 h after returning to ward (T4), 12 h after returning to ward (T5) and 24 h after returning to ward (T6), respectively.</p><p><strong>Results: </strong>There were no significant differences in extubation time, recovery time, or unguardianship time among the three groups (<i>P</i>>0.05). The incidence of postoperative delirium was significantly lower in the 0.1 μg/kg dexmedetomidine group and 0.5 μg/kg dexmedetomidine group compared to the normal saline group (P<0.05), with the 0.5 μg/kg group showing better results. At T2, heart rate (HR) and mean arterial pressure (MAP) levels were significantly lower in 0.1 μg/kg group and 0.5 μg/kg dexmedetomidine group than those in normal saline group (P<0.05). The mYPAS-SF score was significantly lower in the 0.1 μg/kg group and 0.5 μg/kg dexmedetomidine groups than that of the normal saline group at T3, T4 and T5 (P<0.05). The score of pharyngeal pain during swallowing was significantly lower in the 0.5 μg/kg dexmedetomidine group at T5 than that of the normal saline group and 0.1 μg/kg dexmedetomidine group (P<0.05). Coagulation values (PT, APTT, and TT) were significantly altered 36 hours post-surgery, with PT, APTT, and TT increasing, while fibrinogen (FIB) decreased (P<0.05). Postoperative nasopharyngeal hemorrhage occurred in one case and nausea/vomiting in two cases in the saline group. No anesthesia-related adverse reactions were observed in the dexmedetomidine group.</p><p><strong>Conclusion: </strong>Intravenous injection of 0.5 μg/kg dexmedetomidine during plasma resection of tonsillar adenoids can reduce the incidence of postoperative delirium, stabilize hemodynamics, relieve postoperative anxiety and pharyngeal pain, with minimal impacts on coagulation function. Additionally, it reduces the incidence of adverse reactions, making it a promising option for clinical use.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"2188-2196"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}