American journal of translational research最新文献

{"title":"Factors based on Cox regression modeling to analyze the prognostic impact of fiberoptic bronchoscopic bronchoalveolar lavage on children with severe pneumonia.","authors":"Wenyu Ma, Yi Wang, Qinghua Dang, Xianxia Zhang","doi":"10.62347/OGZD3131","DOIUrl":"10.62347/OGZD3131","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify factors influencing the prognosis of children with severe pneumonia (SP) after fiberoptic bronchoscopic bronchoalveolar lavage (BAL).</p><p><strong>Methods: </strong>The clinical data of 155 children with SP treated with fiberoptic bronchoscopic BAL at Xi'an International Medical Center Hospital between January 2022 and January 2024 were retrospectively analyzed. Children were categorized into the survival group (n = 122) and the death group (n = 33) according to their clinical outcomes within 28 days after treatment. General patient data and the initial laboratory results after admission were collected. Univariate and multivariate Cox regression analyses were performed to identify independent predictors of 28-day prognosis. The predictive ability of each index was evaluated using the receiver operating characteristic (ROC) curve analysis and the Delong test. The relationship between each index and the prognosis of children with SP was analyzed using the Kaplan-Meier curve.</p><p><strong>Results: </strong>The death group had significantly younger patients, longer pneumonia course, shorter pregnancy cycle, and higher levels of procalcitonin (PCT), white blood cell count (WBC), C-protein reaction (CPR), and systemic immune-inflammation index (SII) compared to the survival group (P<0.05). Cox regression analysis identified age (HR = 0.959, P = 0.014), pneumonia course (HR = 2.270, P<0.001), pregnancy cycle (HR = 2.736, P = 0.015), PCT (HR = 2.728, P = 0.001), WBC (HR = 1.283, P = 0.001), and SII (HR = 1.009, P<0.001) as independent predictors of 28-day mortality in children with SP. Among these, pneumonia course, PCT, and SII demonstrated higher predictive efficacy in adverse outcomes, with areas under the ROC curve (AUC) of 0.827, 0.822, and 0.868, respectively, outperforming age, pregnancy cycle, and WBC (P<0.05). Kaplan-Meier survival curves showed that patients with older age, shorter pneumonia course, full-term birth, and those with lower WBC, PCT, and SII levels had significantly higher survival rates compared to their counterparts (P<0.05).</p><p><strong>Conclusion: </strong>Age, pneumonia course, pregnancy cycle, WBC, PCT, and SII were independent predictors of survival in children with SP after fiberoptic bronchoscopic BAL, among which pneumonia course, PCT, and SII showed a higher predictive efficacy for the prognosis of children with SP.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7645-7655"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine prostate cancer drivers SOX2 and BRN2 confer differential responses to imipridones ONC201, ONC206, and ONC212 in prostate cancer cell lines.","authors":"Connor Purcell, Praveen R Srinivasan, Maximilian Pinho-Schwermann, William J MacDonald, Elizabeth Ding, Wafik S El-Deiry","doi":"10.62347/NBNQ6383","DOIUrl":"https://doi.org/10.62347/NBNQ6383","url":null,"abstract":"<p><strong>Objectives: </strong>Prostate cancer (PCa) is a leading cause of cancer death in men worldwide. Approximately 30% of castrate-resistant PCa becomes refractory to therapy due to neuroendocrine differentiation (NED) that is present in <1% of de-novo tumors. First-in-class imipridone ONC201/TIC10 therapy has shown clinical activity against midline gliomas, neuroendocrine tumors, and PCa. We explored whether NED promotes sensitivity to imipridones ONC201 and ONC206 by inducibly overexpressing SOX2 and BRN2, well-known neuroendocrine drivers.</p><p><strong>Methods: </strong>Inducible SOX2 or BRN2 systems were cloned into human PCa cell lines LNCaP and DU145. Inducible cell lines were characterized based on protein expression, morphology, and migration. The sensitivity of the inducible cell lines to imipridone therapy was determined by viability, cell growth, or clonogenic assays.</p><p><strong>Results: </strong>Slight protection from ONC201 or ONC206 with SOX2 and BRN2 overexpression was observed in the inducible LNCaP cells but not in the DU145 cells. At 2 months, there was an apparent increase in CLpP expression in LNCaP SOX2-overexpressing cells, though this did not confer enhanced sensitivity to ONC201. DU145 SOX2-overexpressing cells had a significantly reduced ONC201 sensitivity than DU145 control cells.</p><p><strong>Conclusions: </strong>The results suggest that treatment of castrate-resistant prostate cancer by imipridones may not be substantially affected by neuroendocrine differentiation as a therapy-resistance mechanism. The results support further testing of imipridones across subtypes of androgen-sensitive and castrate-resistant prostate cancer.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7972-7982"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of IgE, fractional of exhaled nitric oxide, and peripheral blood eosinophils in adult bronchial asthma and their relationship with disease severity.","authors":"Liping Fang, Yan Shen, Tao Huang, Meiman Wu, Xinglong Duan","doi":"10.62347/ISDG3545","DOIUrl":"https://doi.org/10.62347/ISDG3545","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic value of immunoglobulin E (IgE), fractional of exhaled nitric oxide (FeNO), and peripheral blood eosinophils (EOS) in adult bronchial asthma and to analyze their relationship with asthma severity.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 336 patients diagnosed with bronchial asthma and admitted to Xi'an Fourth Hospital from January 2022 to January 2024, forming the asthma group. Additionally, another 127 healthy subjects were selected as the non-asthmatic control group. The patients in the asthma group were categorized into a mild asthma group (n=138), a moderate asthma group (n=115), and a severe asthma group (n=83) according to the severity of the disease. Clinical data, lung function indices, and IgE, FeNO, and EOS levels were compared across groups. ROC curves were used to assess the diagnostic value of IgE, FeNO, and EOS levels for bronchial asthma. Spearman's rank correlation analysis was used to analyze the correlation between IgE, FeNO, EOS and other indicators and asthma severity.</p><p><strong>Results: </strong>The levels of IgE, FeNO, and EOS were significantly higher in the asthma group than those in the non-asthma group, while lung function indices, peak expiratory flow rate (PEF) and forced expiratory volume in 1 s (FEV1), were significantly lower (all P < 0.05). The areas under curve (AUCs) of IgE, FeNO, and EOS for the diagnosis of asthma were 0.79, 0.93, and 0.88, respectively. Significant differences were observed in smoking history, family history of asthma, co-existing allergic rhinitis, and combined atopic eczema across different severity groups (all P < 0.05). Spearman's rank correlation analysis showed that IgE, FeNO, and EOS were positively correlated with asthma severity (all P < 0.05), with <i>r</i> _s values of 0.718, 0.679, and 0.540, respectively.</p><p><strong>Conclusion: </strong>IgE, FeNO, and EOS are valuable in diagnosing bronchial asthma in adults. Higher levels of IgE, FeNO, and EOS correspond to increased asthma severity, making these biomarkers useful for assessing asthma severity.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7521-7529"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: CCDC26 knockdown enhances resistance of gastrointestinal stromal tumor cells to imatinib by interacting with c-KIT.","authors":"Ke Cao, Minhuan Li, Ji Miao, Xiaofeng Lu, Xing Kang, Hao Zhu, Shangce Du, Xue Li, Qian Zhang, Wenxian Guan, Ying Dong, Xuefeng Xia","doi":"10.62347/RANJ9550","DOIUrl":"https://doi.org/10.62347/RANJ9550","url":null,"abstract":"<p><p>[This corrects the article on p. 274 in vol. 10, PMID: 29423012.].</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"8083-8086"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of 'Internet Plus' remote management in improving cardiac rehabilitation outcomes in acute myocardial infarction patients.","authors":"Yuan Wu, Fan Yang, Yan Feng, Qijin Xu, Haixiang Zhu","doi":"10.62347/FFGR2850","DOIUrl":"https://doi.org/10.62347/FFGR2850","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the effectiveness of \"Internet Plus\" remote management in enhancing cardiac rehabilitation outcomes for patients with acute myocardial infarction (AMI) following percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>A total of 101 AMI patients post-PCI from Sir Run Run Shaw Hospital were included between December 2021 and November 2022. Patients were retrospectively categorized into two groups based on the type of care they received: the control group receiving standard post-PCI rehabilitation, and the observation group receiving remote management via \"Internet Plus\" for six months. Assessed outcomes included the 6-minute walk test (6MWT), Duke Activity Status Index (DASI) scores, exercise rehabilitation compliance, mental health scores using the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), and rates of major cardiovascular events and unplanned rehospitalizations.</p><p><strong>Results: </strong>No significant baseline differences were observed between the two groups. The observation group exhibited significantly longer 6MWT distances and higher DASI scores at subsequent follow-ups (all P < 0.05). Rehabilitation compliance was also higher in the observation group, with 91.49% achieving excellent compliance compared to 72.34% in the control group (P < 0.05). Mental health improvements were also noted, with the observation group showing lower SAS and SDS scores at the three-month follow-up (both P < 0.05). The incidence of major cardiovascular events was 11.11% in the observation group, significantly lower than 27.66% in the control group (P = 0.034). The incidence of unplanned rehospitalization rates was 7.41% in the observation group, also significantly lower than 23.40% in the control group (P = 0.024).</p><p><strong>Conclusion: </strong>The \"Internet Plus\" remote management significantly enhances exercise tolerance, cardiac rehabilitation compliance, and mental health while reducing the incidences of adverse cardiovascular events and rehospitalizations in AMI patients post-PCI. These findings suggest that integrating digital technology into cardiac rehabilitation programs can effectively improve patient outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7667-7677"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of CO₂ laser combined with 5-aminolevulinic acid photodynamic therapy in treating periungual and plantar warts.","authors":"Yuanyuan Li, Qiang Wang, Wenjun Zhong, Xinfeng Pan, Minhong Zhang, Liqiao Chi","doi":"10.62347/FRPZ7345","DOIUrl":"https://doi.org/10.62347/FRPZ7345","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical application value of CO₂ laser combined with 5-aminolevulinic acid photodynamic therapy for periungual and plantar warts.</p><p><strong>Methods: </strong>Data from patients with periungual and plantar warts treated at Qingpu branch of Zhongshan Hospital, Fudan University between August 2022 and January 2024 were retrospectively analyzed. After screening based on inclusion and exclusion criteria, 96 patients were included and categorized into two groups according to their treatment regimens: a combination group (n=50, receiving CO₂ laser therapy and 5-aminolevulinic acid photodynamic therapy) and a control group (n=46, undergoing CO₂ laser treatment alone). The two groups were compared in terms of wart scores before and after treatment, clinical efficacy, recurrence rates during follow-up, and incidence of adverse reactions.</p><p><strong>Results: </strong>During the 4th, 6th, and 8th weeks of treatment, the wart scores of patients in the combination group were significantly lower than those of the control group (<i>P</i><0.05), and at these intervals, the overall treatment efficacy in the combination group was significantly higher than that of the control group (<i>P</i><0.05). At 3-month follow-up, the recurrence rate in the combination group (2.00%) was lower than that in the control group (10.87%) (<i>P</i><0.05). At the 2nd, 4th, 6th, and 8th weeks of treatment, the Visual Analog Scale scores in the combination group were significantly reduced compared to the control group (<i>P</i><0.05). No significant difference was found in the incidence of adverse reactions between the two groups during follow-up (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The application of CO₂ laser therapy combined with 5-aminolevulinic acid photodynamic therapy is effective for patients suffering from periungual and plantar warts, and this combination enhances clinical outcome, mitigates pain, and reduces short-term recurrence.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7364-7373"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preemptive hydromorphone analgesia reduces postoperative delirium and stress response in laparoscopic cholecystectomy patients.","authors":"Weitao Zhang, Yanni Yang, Yuqiang Yan","doi":"10.62347/HFRZ2901","DOIUrl":"10.62347/HFRZ2901","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of preemptive hydromorphone analgesia on postoperative delirium and stress response in patients undergoing laparoscopic cholecystectomy.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted, including 167 patients who underwent laparoscopic cholecystectomy at Xi'an Central Hospital between June 2021 and November 2023. Patients were categorized into an observation group (n=87) receiving preemptive hydromorphone hydrochloride analgesia and a control group (n=80) without preemptive analgesia. Postoperative pain was assessed using the Visual Analogue Scale (VAS), and stress response was evaluated by measuring epinephrine, norepinephrine, and dopamine levels. The incidence of postoperative delirium was recorded. Logistic regression analysis was performed to identify risk factors for postoperative delirium.</p><p><strong>Results: </strong>The VAS score at 30 minutes postoperative was significantly lower in the observation group than that in the control group (P<0.001). Similarly, postoperative levels of epinephrine, norepinephrine, and dopamine were significantly reduced in the observation group (all P<0.001). The incidence of postoperative delirium was also significantly lower in the observation group (P<0.05). Multivariate logistic regression analysis identified higher doses of propofol (P<0.001; odds ratio =3.102, 95% confidence interval: 1.144-9.777) and remifentanil (P=0.001; odds ratio =2.376, 95% confidence interval: 1.469-4.290) as independent risk factors for postoperative delirium, indicating a significant increase in delirium risk with higher drug doses.</p><p><strong>Conclusion: </strong>Preemptive hydromorphone analgesia significantly alleviates postoperative pain, reduces stress responses, and lowers the incidence of postoperative delirium in patients undergoing laparoscopic cholecystectomy. Compared to conventional analgesia strategies, hydromorphone provides superior pain control and a favorable safety profile.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7427-7437"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictive model for moderate to severe perivalvular leakage following transcatheter aortic valve replacement.","authors":"Huajun Wang, Xueda Wu, Hang Zhang, Fengwu Shi, Nan Dong, Jinghui An","doi":"10.62347/VRXS6310","DOIUrl":"10.62347/VRXS6310","url":null,"abstract":"<p><strong>Objective: </strong>To identify the risk factors associated with moderate to severe perivalvular leakage (PVL) after transcatheter aortic valve replacement (TAVR) and to construct a prediction model for this risk.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 128 patients with severe aortic stenosis who had received TAVR in The Second Hospital of Hebei Medical University from January 2019 to January 2024. The length of the aortic regurgitation bundle and annular circumference ratio were measured by transesophageal echocardiography immediately after the valve implantation. Patients with moderate to severe PVL were included in observation group, while the remaining comprised the control group. Clinical data of the patients were recorded, and univariate and multivariate Logistic regression analyses were performed on factors potentially influencing the development of moderate to severe PVL after surgery. A risk prediction model was constructed correspondingly.</p><p><strong>Results: </strong>Of the 128 patients, 51 with moderate or severe PVL served as the observation group and the remaining 77 served as the control group. The results of univariate and multivariate analyses identified LVOT coverage index, depth of valve implantation, LVEDd, aortic angulation, LVESD, and calcification volume entered as independent risk factors associated with moderate to severe PVL following TAVR (<i>P<0.05</i>). A predictive model for post-TAVR PVL was constructed by incorporating these significant factors. ROC curve analysis of the prediction model for moderate to severe PVL showed an area under the curve of 0.911.</p><p><strong>Conclusion: </strong>LVOT coverage index, depth of valve implantation, LVEDd, aortic angulation, LVESD, and calcification volume are independent risk factors for moderate to severe PVL in patients with severe aortic stenosis after TAVR. Risk prediction model constructed based on the risk factors are valuable tool for identifying patients at high risk of developing moderate or greater PVL post-surgery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7563-7572"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of warm needle therapy guided by ultrasound on pain relief and improvement of physical function in patients with knee osteoarthritis.","authors":"Yong Yuan, Ping Li","doi":"10.62347/KFNE8547","DOIUrl":"10.62347/KFNE8547","url":null,"abstract":"<p><strong>Background: </strong>Conventional treatments for knee osteoarthritis (KOA) often fall short in providing optimal outcomes.</p><p><strong>Objective: </strong>To evaluate the effect of warm needle therapy guided by ultrasound on pain relief and physical function in patients with KOA.</p><p><strong>Methods: </strong>In this retrospective study, the clinical records of patients with KOA undergoing either meloxicam alone or meloxicam combined with warm needle therapy were reviewed. Various parameters, including pain evaluations, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, range of motion for knee flexion, knee society scores, quality of life scores, inflammatory factor levels, and patient satisfaction were comparatively analyzed.</p><p><strong>Results: </strong>A total of 140 patients were included, including 68 patients treated by Meloxicam and 72 patients treated by Meloxicam and warm needle therapy. Following treatment, the meloxicam combined with warm needle therapy group exhibited lower pain scores (3.62±1.98 vs. 4.38±1.95, P=0.023), improved WOMAC scores (27.82±8.75 vs. 31.25±8.82, P=0.022), increased range of motion (136.82°±8.58° vs. 133.43°±8.86°, P=0.023), higher knee society scores (93.32±7.21 vs. 90.21±7.78, P=0.016), and superior Short Form-36 Health Survey (SF-36) scores (81.24±6.33 vs. 78.43±6.85, P=0.013). Furthermore, a significant reduction in inflammatory factors including interleukin-8 (IL-8), matrix metalloproteinase-3 (MMP-3), Interleukin-1 beta (IL-1β), Tumor Necrosis Factor-alpha (TNF-α), and cyclooxygenase-2 (COX-2) levels was observed in the meloxicam combined with warm needle therapy group compared to the meloxicam alone group (all P<0.05). Patient satisfaction was likewise notably higher in the meloxicam combined with warm needle therapy group (8.43±2.15 vs. 7.58±2.24, P=0.024), with a greater proportion of patients willing to recommend the treatment (81.94% vs. 64.71%, P=0.034).</p><p><strong>Conclusion: </strong>Warm needle therapy guided by ultrasound, in combination with meloxicam, significantly improves pain relief, physical function, inflammatory modulation, and patient satisfaction in KOA patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"7467-7479"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of nalbuphine and dezocine for postoperative analgesia in elderly patients undergoing laparoscopic radical gastric cancer surgery.","authors":"Wenquan Zeng, Bingyun Zeng, Mingyuan Xing, Heping Li","doi":"10.62347/NJIA6803","DOIUrl":"10.62347/NJIA6803","url":null,"abstract":"<p><strong>Objective: </strong>Gastric cancer is a prevalent and significant malignancy that occurs throughout the world, with a particularly pronounced impact on the elderly population. This study aims to compare the efficacy of nalbuphine and dezocine in managing pain following laparoscopic radical gastrectomy.</p><p><strong>Method: </strong>Elderly patients undergoing laparoscopic radical gastrectomy were divided into a nalbuphine (n=50) group and a dezocine (n=50) group according to their anesthesia agent. Anesthesia methods included preoperative intravenous administration of either 0.15 mg/kg nalbuphine or 0.1 mg/kg dezocine, followed by continuous propofol infusion during surgery. Pain and sedation levels were assessed using the VAS and Ramsay Sedation Scale. Secondary indicators included postoperative pain indicators, hemodynamic parameters, recovery time, and adverse anesthetic reactions.</p><p><strong>Results: </strong>There were no significant differences in baseline data between the two groups, including gender, age, body weight, ASA classification, gastric cancer stage, and surgery duration (all P > 0.05). The nalbuphine group showed superior postoperative pain management compared to the dezocine group, with lower VAS, RSS, inflammatory levels (SP and IL-6) and stress response indicators (all P < 0.05). The nalbuphine group also had shorter awakening time, higher awakening quality, shorter surgery time, and earlier extubation time. Furthermore, the incidence of adverse events was lower in the nalbuphine group.</p><p><strong>Conclusion: </strong>Nalbuphine provides better postoperative pain relief and was associated with fewer adverse events in elderly patients undergoing laparoscopic radical gastrectomy. These findings suggest that nalbuphine is a safer and more effective analgesic option in this clinical context.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 12","pages":"8073-8082"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}