American journal of translational research最新文献

{"title":"Modulation of immune responses by acupuncture at Jing-Well points in neurological disorders: exploring mechanisms and clinical applications in the era of modern electrophysiology.","authors":"Liang Gao, Ruoyu Yuan","doi":"10.62347/WSHR3490","DOIUrl":"10.62347/WSHR3490","url":null,"abstract":"<p><strong>Background: </strong>Neurological disorders are increasingly recognized as complex conditions involving extensive neuroimmune dysregulation, chronic inflammation, oxidative stress, autonomic imbalance, and progressive neuronal injury. Emerging evidence suggests that acupuncture, including stimulation at Jing-Well points, may exert immunomodulatory and neuromodulatory effects through interactions with peripheral sensory pathways, autonomic networks, inflammatory signaling cascades, and central nervous system electrophysiology. Recent advances in neuroimaging, electrophysiology, and molecular neuroscience have provided important mechanistic insights into the therapeutic potential of acupuncture in neurological diseases.</p><p><strong>Objective: </strong>This review aims to comprehensively explore the mechanisms by which acupuncture at Jing-Well points modulates immune responses in neurological disorders, with particular emphasis on neuroimmune interactions, electrophysiological mechanisms, and contemporary clinical applications.</p><p><strong>Methods: </strong>A narrative review of the current literature was conducted using evidence derived from experimental studies, clinical investigations, neuroimaging analyses, electrophysiological studies, and systematic reviews indexed in PubMed, Scopus, and Web of Science. Relevant studies evaluating acupuncture-mediated immune regulation, autonomic modulation, neuroinflammation, electrophysiological alterations, and neurological rehabilitation were critically analyzed and synthesized.</p><p><strong>Results: </strong>Available direct evidence regarding Jing-Well point stimulation remains limited. However, findings from broader acupuncture and electroacupuncture research suggest potentially relevant neuroimmune, autonomic, anti-inflammatory, and electrophysiological effects, including modulation of cytokine signaling, glial activation, oxidative stress, autonomic balance, cortical excitability, and neural connectivity. The extent to which these effects are specific to Jing-Well point stimulation remains to be established.</p><p><strong>Conclusion: </strong>Jing-Well point acupuncture may represent a potentially useful adjunctive neuromodulatory approach in neurological disorders. Current evidence, derived predominantly from broader acupuncture and electroacupuncture research, supports the biological plausibility of anti-inflammatory, autonomic, neuroprotective, and electrophysiological effects; however, Jing-Well-specific mechanisms and clinical benefits have not yet been firmly established. Standardized multicenter studies integrating molecular biomarkers, electrophysiological monitoring, neuroimaging, and clinically meaningful outcomes are required.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7365-7390"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for subdural hematoma in spontaneous intracranial hypotension are male sex, longer disease duration, and repeated epidural blood patches.","authors":"Qunli Xu, Lanjun Shen, Lanlan Zhou, Tingting Li","doi":"10.62347/OPON7032","DOIUrl":"10.62347/OPON7032","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical characteristics and risk factors for subdural hematoma (SDH) in patients with spontaneous intracranial hypotension (SIH), with a focus on male sex, disease duration, and repeated epidural blood patch (EBP) procedures.</p><p><strong>Methods: </strong>This retrospective cohort study included 579 consecutive SIH patients admitted between June 2019 and November 2025. Patients were divided into an SDH group (n = 101) and a non-SDH group (n = 478) based on brain imaging. Demographic data, clinical characteristics, laboratory parameters, brain imaging features, spinal imaging findings, and treatment details were collected.</p><p><strong>Results: </strong>SDH patients were more frequently male (60.4% vs. 32.4%, P < 0.001), older (45.4 ± 12.7 vs. 41.6 ± 9.5 years, P = 0.005), and had longer disease duration (52.3 ± 23.1 vs. 39.2 ± 18.3 days, P < 0.001). They exhibited higher systolic blood pressure (122.7 ± 16.4 vs. 118.8 ± 16.4 mmHg, P = 0.033) and more neurological deficits (30.7% vs. 10.3%, P < 0.001). Brain imaging showed increased frequency of brain sagging (55.5% vs. 40.8%, P = 0.007), dural enhancement (80.2% vs. 64.4%, P = 0.002), venous distension (56.4% vs. 39.1%, P = 0.001), and subdural effusion (36.6% vs. 25.5%, P = 0.023) in the SDH group. Spinal imaging revealed more identifiable leaks (93.1% vs. 77.8%, P < 0.001). The SDH group underwent more EBP procedures (1.43 ± 0.64 vs. 1.23 ± 0.51, P = 0.004). Multivariate analysis identified male sex, age, disease duration, dural enhancement, and number of EBP procedures as independent SDH risk factors (P < 0.05).</p><p><strong>Conclusion: </strong>Male sex, longer disease duration, dural enhancement on brain imaging, and repeated EBP procedures were independent risk factors for SDH in patients with SIH, highlighting a need for close monitoring in high-risk individuals.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6771-6781"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fibular rotation and sagittal shift on postoperative function in ankle fractures with syndesmotic injury.","authors":"Jianliang Li, Xingzhang Yao, Jia Wang, Jiwei Zhang, Hui Yao, Chun Yang, Bingyang Fan, Yanlong Jia","doi":"10.62347/VQHK9706","DOIUrl":"10.62347/VQHK9706","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate whether postoperative radiographic and functional outcomes in ankle fractures with syndesmotic injury are associated with a CT-based grading system based on fibular rotation (FR) and sagittal shift distance (SSD), and to assess the influence of surgical timing and patient-related factors on prognosis.</p><p><strong>Methods: </strong>This retrospective cohort study included 370 patients with ankle fractures and syndesmotic injury treated with open reduction and internal fixation between June 2021 and September 2024. Based on preoperative CT measurements, patients were classified into three groups: Group A (FR < 5° and SSD < 2 mm), Group B (5° ≤ FR ≤ 10° or 2 mm ≤ SSD ≤ 5 mm), and Group C (FR > 10° or SSD > 5 mm). Radiographic reduction quality, loss of reduction at 6 months, functional outcomes (SF-36, AOFAS, VAS, ankle range of motion), complications, and reoperations were compared. Inverse probability of treatment weighting and propensity score matching were applied. Multivariate logistic regression was used to identify independent predictors of poor prognosis (final AOFAS < 80), and interaction analyses were performed.</p><p><strong>Results: </strong>Patients with high-grade syndesmotic malalignment (Group C) had significantly poorer radiographic reduction, higher rates of loss of reduction, complications, and reoperation, and inferior functional outcomes compared to Groups A and B (all P < 0.001). Multivariate analysis identified older age, surgical delay, diabetes, higher body mass index, Weber C fracture, posterior malleolar fracture, and loss of reduction at 6 months as independent risk factors for poor prognosis. A significant interaction was observed between syndesmotic injury grade and surgical delay.</p><p><strong>Conclusions: </strong>CT-based FR/SSD grading is useful for identifying high-risk syndesmotic malalignment in ankle fracture. Postoperative outcomes are primarily influenced by patient characteristics, fracture pattern, surgical timing, and maintenance of reduction, underscoring the importance of timely surgery and stable syndesmotic reduction, particularly for more severe injuries.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7236-7258"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective predictive model for worsening knee osteoarthritis pain by integrating baseline gait biomechanics and wearable gait parameters.","authors":"Kun Li, Yun Yang, Jie Zhou, Liangyu Lu","doi":"10.62347/ORTB8274","DOIUrl":"10.62347/ORTB8274","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the performance of a predictive model for worsening knee osteoarthritis (KOA) pain that integrates baseline clinical characteristics, gait biomechanical parameters and wearable device-derived daily activity monitoring data and to evaluate the incremental predictive value of each module.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 984 KOA patients who visited the Department of Orthopedics, Pudong New Area People's Hospital between January 2018 and December 2023 were retrospectively included and randomly split into a training set (n = 689) and a test set (n = 295) at a 7:3 ratio. The primary outcome was a composite endpoint defined as an increase of ≥ 2 points in the WOMAC pain subscale score within 12 months after enrollment, accompanied by subjective patient-reported pain worsening (incidence, 28.0%). In the training set, candidate variables were initially screened by univariate analysis (P &lt; 0.05) and final predictors were selected using LASSO regression with 10-fold cross-validation (lambda.1se = 0.012253). Four logistic regression models (clinical model, clinical + gait model, clinical + wearable model and fusion model) were constructed using a stepwise modular incremental strategy. Model discrimination was assessed using the area under the receiver operating characteristic curve (AUC), calibration using the Brier Score and calibration curves, incremental predictive value using integrated discrimination improvement (IDI) and net reclassification improvement (NRI) and clinical utility using decision curve analysis (DCA). Variable importance was assessed using multivariable logistic regression and SHAP method.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 17 variables were selected by LASSO (7 clinical variables, 4 gait-related variables and 6 wearable-derived variables). In the test set, the AUCs of the clinical model, clinical + gait model, clinical + wearable model and fusion model were 0.673 (95% CI: 0.605-0.740), 0.753 (95% CI: 0.695-0.811), 0.756 (95% CI: 0.695-0.816) and 0.815 (95% CI: 0.761-0.869), respectively. The fusion model achieved a Brier score of 0.144, a calibration intercept of -0.261 and a calibration slope of 0.856. Compared with the clinical model, the IDIs of the clinical + gait, clinical + wearable and fusion models were 0.056, 0.123 and 0.217, respectively and the continuous NRIs were 0.606, 0.614 and 0.697, respectively (all P &lt; 0.05). Multivariable logistic regression identified baseline WOMAC stiffness score (OR = 1.912, 95% CI: 1.583-2.331, P &lt; 0.001), analgesic use (OR = 1.753, P = 0.009) and daytime activity fragmentation index (per 0.1-unit increase, OR = 1.948, 95% CI: 1.597-2.402, P &lt; 0.001) as independent variables risk factors for worsening pain. Regular exercise habits (OR = 0.630, P = 0.033), 20-m walk speed (per 0.1 m/s increase, OR = 0.748, 95% CI: 0.647-0.859, P &lt; 0.001) and sedentary break frequency (OR = 0.780 per break/hour, P = 0.023) were independently associa","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7118-7140"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational screening of natural product inhibitor stargeting the MDM2-p53 interaction: docking and molecular dynamics insights for retinoblastoma therapy.","authors":"Yulei Geng, Xiaoli Liu, Sanjay Kumar, Yuxin Geng","doi":"10.62347/LYUA9855","DOIUrl":"10.62347/LYUA9855","url":null,"abstract":"<p><strong>Objectives: </strong>To identify potential natural-product-derived inhibitors of the MDM2-p53 interaction for retinoblastoma therapy through an integrated computational screening strategy and to evaluate their binding stability, pharmacokinetic properties, and electronic characteristics.</p><p><strong>Methods: </strong>The crystal structure of MDM2 (PDB ID: 3VZV) was validated using ERRAT and Ramachandran plot analyses. A curated natural compound library from the COCONUT database was screened by molecular docking using PyRx. Top-ranked compounds were evaluated through ADMET and toxicity prediction using SwissADME and Protox 3.0. The selected lead compound, Pentamorphone, was further investigated by 500-ns molecular dynamics simulations, MM/GBSA and MM/PBSA binding free-energy calculations, and density functional theory (DFT) analyses.</p><p><strong>Results: </strong>Pentamorphone demonstrated favorable binding within the MDM2 hydrophobic pocket and exhibited acceptable pharmacokinetic and toxicity profiles. Molecular dynamics simulations confirmed the stability of the MDM2-Pentamorphone complex, as evidenced by stable RMSD, RMSF, radius of gyration, and persistent hydrogen-bond interactions throughout the 500-ns trajectory. Binding free-energy calculations indicated thermodynamically favorable complex formation, with MM/GBSA and MM/PBSA energies of -60.41 and -58.72 kcal/mol, respectively. DFT analysis revealed a HOMO-LUMO energy gap of 3.96 eV, supporting the compound's electronic stability and potential for favorable target interactions.</p><p><strong>Conclusions: </strong>The integrated computational analyses identified Pentamorphone as a promising candidate capable of disrupting the MDM2-p53 interaction. These findings support its further experimental evaluation as a potential therapeutic lead for retinoblastoma characterized by MDM2-mediated suppression of p53.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7391-7404"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and multidimensional mechanisms of close-to-bone needling in knee osteoarthritis: a randomized controlled trial.","authors":"Yumei Lu, Huiying Wu, Nini Fu, Qian Su, Qi Zeng, Yifan He, Yi Ren","doi":"10.62347/NGZG8291","DOIUrl":"10.62347/NGZG8291","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the clinical efficacy of close-to-bone needling (CBN) in patients with knee osteoarthritis (KOA) and to explore its underlying mechanisms.</p><p><strong>Methods: </strong>Seventy patients with KOA were randomized to receive either CBN (n=35) or oral celecoxib (Drug Group, DG, n=35) for a 4-week intervention period, followed by a 2-week follow-up. Additionally, 35 healthy controls (HC) were enrolled. Clinical outcomes were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Index of Severity for Osteoarthritis of the Knee (ISOA), and the 36-Item Short Form Health Survey (SF-36). Structural alterations were evaluated by magnetic resonance imaging (MRI)-based Whole-Organ Magnetic Resonance Imaging Score (WORMS) and musculoskeletal ultrasound. Molecular changes were assessed by quantifying plasma and synovial fluid levels of miR-140, miR-30, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). Neural correlates were assessed via resting-state electroencephalography (EEG), including spectral power analysis and graph-theoretical analysis of brain network characteristics.</p><p><strong>Results: </strong>Compared with the DG group, the CBN group showed significantly greater overall clinical efficacy at 6 weeks (P<0.05), with greater improvements in WOMAC, ISOA, and SF-36 scores, as well as greater reductions in cartilage degeneration, synovial thickening, and joint effusion (P<0.05). Furthermore, CBN produced stronger modulatory effects on miR-140, miR-30, IL-1β, and TNF-α levels (P<0.05). EEG analysis revealed reduced Delta and Theta power, increased Alpha, Beta, and Gamma power in frontoparietal regions, and normalization of abnormal prefrontal connectivity patterns in the Theta and Gamma frequency bands (P<0.05).</p><p><strong>Conclusion: </strong>CBN represents an effective non-pharmacological intervention for KOA, with advantages over celecoxib in symptom relief, joint structure improvement, molecular regulation, and central neural normalization. The proposed \"brain-molecule-clinic\" assessment framework provides multidimensional evidence supporting the potential mechanisms of acupuncture-based interventions in KOA.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7420-7437"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in peripapillary retinal nerve fiber layer thickness, macular fovea thickness, and perimacular retinal nerve fiber layer thickness in children with hyperopic amblyopia.","authors":"Mochi Yang, Limeng Wang, Juan Lou, Ruiwen Gao, Siqi Sheng, Jiaojiao Ren, Ruitian Li, Zeinab Sheikhzadeh","doi":"10.62347/PVDL7180","DOIUrl":"10.62347/PVDL7180","url":null,"abstract":"<p><strong>Objective: </strong>To compare peripapillary retinal nerve fiber layer thickness (RNFLT), macular foveal thickness, and perimacular RNFLT in children with hyperopic amblyopia using optical coherence tomography (OCT).</p><p><strong>Methods: </strong>This retrospective case-control study included 140 children (214 eyes) with hyperopic amblyopia and 60 normal children (120 eyes) examined from June 2023 to June 2024. Amblyopia severity was classified according to best-corrected visual acuity (BCVA) in the amblyopic eye as mild (20/32-20/40), moderate (>20/40-20/100), or severe (>20/100). OCT was used to measure peripapillary RNFLT, foveal thickness, and perimacular RNFLT. Correlations with axial length and spherical equivalent refraction were analyzed, and multivariable logistic regression was performed.</p><p><strong>Results: </strong>Compared with controls, children with moderate and severe amblyopia had significantly greater peripapillary RNFLT, macular foveal thickness, and inner-ring perimacular RNFLT (<i>P</i><0.05). Severe amblyopia showed thicker superior, nasal, and temporal peripapillary RNFLT and greater foveal thickness than mild amblyopia (<i>P</i><0.05). Peripapillary RNFLT was positively correlated with spherical equivalent refraction. Superior peripapillary RNFLT, superior inner-ring perimacular RNFLT, and foveal thickness were independently associated with moderate-to-severe amblyopia (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>OCT demonstrates progressive thickening of selected peripapillary and macular structural parameters with increasing amblyopia severity. These parameters may serve as objective adjunctive markers for severity assessment and follow-up in children with hyperopic amblyopia.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6948-6955"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmine suppresses the malignant phenotypes of Lewis lung carcinoma cells by inhibiting EGFR phosphorylation.","authors":"Xueliang Zhang, Tao Wang, Yonghua Hu, Caihong Fu, Xiaowen Lian, Yan Li, Ruoyu Zhao","doi":"10.62347/ADGG4122","DOIUrl":"10.62347/ADGG4122","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether harmine (HM) suppresses the malignant phenotypes of Lewis lung carcinoma (LLC) cells through an epidermal growth factor receptor (EGFR) -mediated mechanism.</p><p><strong>Methods: </strong>Possible targets of HM and LLC-related genes were obtained from public databases, and overlapping targets were identified. A protein-protein interaction (PPI) network was constructed, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking was performed to predict the binding mode of HM with EGFR. The expression of phosphorylated EGFR (p-EGFR) was examined in LLC cells. <i>In vitro</i> assays were used to evaluate the effects of HM on cell viability, proliferation, colony formation, migration, invasion, and apoptosis. EGFR overexpression was further applied to assess whether EGFR was involved in the effects of HM.</p><p><strong>Results: </strong>A total of 121 overlapping targets between HM and LLC were identified, and EGFR was recognized as a core hub target in the PPI network. Molecular docking predicted that HM could fit into the ATP-binding pocket of EGFR, with a binding energy below -7.0 kcal/mol. In LLC cells, HM showed selective cytotoxicity and significantly inhibited EGFR phosphorylation. HM also reduced cell proliferation, colony formation, migration, and invasion, while promoting apoptosis. These effects were partially reversed by EGFR overexpression.</p><p><strong>Conclusion: </strong>HM suppresses the malignant phenotypes of LLC cells, at least in part, by inhibiting EGFR phosphorylation and EGFR-mediated signaling.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6483-6504"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for predicting adverse perinatal outcomes in hypertensive disorders of pregnancy complicated by fetal growth restriction.","authors":"Qian Wei, Xiao Wang, Zunfeng Fu, Chaoyang Zhao, Jin Wu, Xueqin Ji","doi":"10.62347/PIWM4554","DOIUrl":"10.62347/PIWM4554","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertensive disorders of pregnancy (HDP) when combined with fetal growth restriction (FGR) increase the risk of adverse perinatal outcomes (APO). This study aimed to investigate the predictive value of fetal hemodynamic indicators for APO and to construct a nomogram for individualized risk assessment in pregnancies with HDP and FGR.</p><p><strong>Methods: </strong>This retrospective study included 198 pregnant women with HDP and FGR in the training set and 85 patients in the validation set, admitted between January 2022 and December 2024. Demographic, clinical, biochemical (uric acid, free thyroxine [FT4]), and Doppler parameters (umbilical artery pulsatility index [UA-PI], middle cerebral artery PI [MCA-PI], and cerebroplacental ratio [CPR]) were collected. Multivariate logistic regression was used to identify independent predictors, and a nomogram was constructed.</p><p><strong>Results: </strong>Seven independent predictors were identified: family history of hypertension (odds ratio [OR]=2.986), pre-eclampsia or chronic hypertension with superimposed pre-eclampsia (OR=2.811), uric acid (OR=1.036), FT4 (OR=0.813), abnormal UA-PI (OR=7.262), abnormal MCA-PI (OR=6.620), and abnormal CPR (OR=6.702). The nomogram demonstrated good discrimination, with an area under the curve (AUC] of 0.905 in the training set and 0.806 in the validation set.</p><p><strong>Conclusions: </strong>We developed a nomogram integrating maternal clinical history, serum biomarkers (uric acid, FT4), and fetal Doppler indices that showed good predictive accuracy for APO in HDP complicated by FGR. External validation in multi-center cohorts is required before clinical implementation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6999-7011"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilation-induced gastric rupture after extubation in the ICU: a case report.","authors":"Hyeon Tae Kim, Sang Hi Park, Jin Wook Park, Jeong Eun Moon, Young Duck Shin, Joo Yong Lee","doi":"10.62347/XYZI5379","DOIUrl":"10.62347/XYZI5379","url":null,"abstract":"<p><strong>Background: </strong>Gastric rupture is a rare yet potentially fatal complication that has been reported during cardiopulmonary resuscitation (CPR). This is generally attributed to acute gastric overdistension caused by chest compressions combined with positive-pressure ventilation. Ventilation-induced gastric rupture after planned extubation in the intensive care unit (ICU) is rare.</p><p><strong>Case presentation: </strong>An 80-year-old man developed acute gastric rupture shortly after planned ICU extubation following lumbar spinal surgery. Quantitative neuromuscular monitoring was not performed prior to extubation. Four minutes after extubation, repeated bag-mask ventilation and laryngeal mask airway-assisted ventilation were administered prior to successful reintubation. Progressive abdominal distension was observed during rescue ventilation. Imaging demonstrated massive pneumoperitoneum, while emergency surgery identified a 5-cm longitudinal perforation along the lesser curvature of the stomach without evidence of ischemic discoloration. No CPR was conducted. The patient required prolonged mechanical ventilation and died 2 months later from progressive nosocomial pneumonia.</p><p><strong>Conclusions: </strong>Repeated positive-pressure ventilation after ICU extubation may result in gastric rupture even in the absence of CPR. Awareness of progressive abdominal distension, objective neuromuscular assessments before extubation and careful control of inspiratory pressure may improve airway safety in high-risk patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7342-7345"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}