American journal of translational research最新文献

{"title":"Establishment and validation of a prognostic model for controlling adolescents' myopia progression through repeated low-level red-light therapy.","authors":"Yuan Yang, Guoxin Bai, Shugen Wang, Ruihua Wei","doi":"10.62347/KFVX2641","DOIUrl":"10.62347/KFVX2641","url":null,"abstract":"<p><strong>Background/purpose: </strong>Repeated low-level red-light (RLRL) therapy has emerged as a possible intervention to control myopia progression. This study aimed to establish and validate a prognostic model for controlling adolescents' myopia progression with RLRL therapy, considering demographic, lifestyle, and ophthalmic parameters.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on adolescent myopic patients admitted to Cangzhou Central Hospital from January 2022 to June 2023. Patients were divided into a control group and an RLRL treatment group based on their treatment method. Various demographic, lifestyle, and ophthalmic parameters were assessed to identify predictors for treatment response. A comprehensive evaluation using logistic regression and nomogram analysis was performed to identify significant factors associated with treatment outcomes.</p><p><strong>Results: </strong>The study included a total of 145 patients, comprising 82 in the control group and 63 in the RLRL group. RLRL therapy demonstrated significantly better effectiveness in controlling myopia progression, with a reduction of -0.62 ± 0.24 D in the RLRL group compared to -0.75 ± 0.36 D in the control group (P=0.010). Furthermore, the RLRL group exhibited improved visual acuity (logMAR) of 0.12 ± 0.06 compared to 0.15 ± 0.07 in the control group (P=0.015). Moreover, baseline demographic and ophthalmic characteristics showed significant associations with treatment outcome, emphasizing the multifaceted nature of myopia response to RLRL therapy. The nomogram analysis demonstrated high predictive performance, with an AUC of 0.994.</p><p><strong>Conclusion: </strong>This study demonstrates the effectiveness and safety of RLRL therapy in controlling myopia progression among adolescents. The establishment of a prognostic model incorporating demographic, lifestyle, and ophthalmic factors offer a promising approach for predicting treatment outcome.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2730-2742"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITGA5 promotes cervical cancer progression by regulating IMP3 recruitment of HK2 mRNA.","authors":"Liuxuanning Zhou, Yue Liu, Yan Zhang, Fan Hu, Lu Shen, Shunyu Hou","doi":"10.62347/GGVE9638","DOIUrl":"10.62347/GGVE9638","url":null,"abstract":"<p><p>Cervical cancer is a prevalent gynecologic malignancy characterized by high rates of invasion and metastasis. Integrin alpha 5 (ITGA5), a member of the integrin family, has been implicated in tumor progression; however, its regulatory role in cervical cancer remains poorly defined. Bioinformatic analyses revealed elevated ITGA5 expression in cervical cancer, which was further validated in patient tissues by immunohistochemistry (IHC). ITGA5 was either silenced or overexpressed in cervical cancer cell lines, and its effects on proliferation, invasion, and migration were assessed using CCK-8, Transwell, and wound healing assays. The <i>in vivo</i> effects of ITGA5 knockdown were evaluated through subcutaneous tumor xenografts in nude mice. Mass spectrometry identified insulin-like growth factor II mRNA binding protein 3 (IMP3) as a potential ITGA5-interacting protein. Their interaction was confirmed using co-immunoprecipitation (CO-IP), western blotting, and RNA immunoprecipitation (RIP). ITGA5 was found to be significantly upregulated in cervical cancer and negatively correlated with patient survival. Functionally, ITGA5 promoted proliferation, invasion, and migration of cervical cancer cells <i>in vitro</i> and enhanced tumor growth in vivo. Mechanistically, ITGA5 interacted with IMP3, regulating the recruitment of hexokinase 2 (HK2) mRNA by IMP3. Overexpression of HK2 rescued the inhibitory effects of ITGA5 knockdown on cervical cancer progression. This study presents new findings on the pathogenesis of cervical cancer and identifies a possible therapeutic target.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3031-3049"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of cardiopulmonary exercise test parameters for atrial fibrillation risk in hypertrophic cardiomyopathy patients.","authors":"Ling Wang, Lili Liu, Langtao Guo","doi":"10.62347/KENO8599","DOIUrl":"10.62347/KENO8599","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between cardiopulmonary exercise test (CPET) parameters and the occurrence of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).</p><p><strong>Methods: </strong>A retrospective study was conducted on 160 HCM patients hospitalized at Quanzhou First Hospital Affiliated to Fujian Medical University from June 2020 to December 2023. Patients were divided into AF (n=62) and non-AF (n=98) groups. Univariate analysis and logistic regression were used to compare demographic and CPET parameters between groups. A nomogram model was developed to predict AF risk.</p><p><strong>Results: </strong>AF prevalence was 38.75%. Peak Oxygen Uptake per kilogram (Peak VO₂/kg), Metabolic Equivalent of Task (METs), and Oxygen Uptake at Anaerobic threshold per kilogram (VO₂/kg AT) were lower in the AF group compared to the non-AF group, while Ventilation to Carbon Dioxide Production Slope (VE/VCO₂ slope) was higher (all P<0.05). Pearson correlation analysis showed a significant negative correlation between Peak VO₂/kg and New York Heart Association (NYHA) classification (r=-0.231, P=0.003). Logistic regression identified NYHA classification, smoking history, and VE/VCO₂ slope as risk factors for AF, while Peak VO₂/kg, METs, and VO₂/kg AT were protective factors (P<0.05). The nomogram model had an area under curve (AUC) of 0.867 (0.808-0.925), demonstrating good calibration and clinical utility.</p><p><strong>Conclusion: </strong>CPET parameters, combined with clinical indicators, can effectively predict AF risk in HCM patients. The nomogram model provides a valuable tool for clinical risk assessment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2947-2956"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in cardiac ultrasound speckle tracking technology for assessing left ventricular systolic function after adjuvant radiotherapy following breast-conserving surgery for breast cancer.","authors":"Xin Yang, Wen-Jun Zhou, Guo-Ping Chen, Zong-Fen Zhang, Fang Yi","doi":"10.62347/CDAI6188","DOIUrl":"10.62347/CDAI6188","url":null,"abstract":"<p><p>Breast-conserving surgery is a widely used treatment for breast cancer, often followed by adjuvant therapy such as adjuvant paclitaxel and trastuzumab (APT). While APT effectively reduces local recurrence and distant metastasis, it may also impair left ventricular systolic function. Speckle tracking imaging (STI) is a noninvasive ultrasound technique that quantitatively evaluates overall cardiac function. It allows for the assessment of myocardial fibrosis, myocardial injury, and overall systolic function, making it a valuable tool in clinical practice. This review discusses recent advances in the use of STI for evaluating left ventricular systolic function following APT in breast cancer patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2434-2444"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nedaplatin combined with paclitaxel liposomes or docetaxel on survival rate and biomarkers in patients with recurrent ovarian cancer.","authors":"Jie Deng, Yun Cai, Juan Liao, Ruining Hou, Jie Cui","doi":"10.62347/OMOR8605","DOIUrl":"10.62347/OMOR8605","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of combining nedaplatin with paclitaxel liposomes or docetaxel on survival rates and biomarkers in patients with recurrent ovarian cancer (ROC).</p><p><strong>Methods: </strong>A retrospective analysis was carried out on the clinical data of 238 ROC patients treated at Baoji Traditional Chinese Medicine Hospital between February 2018 and February 2022. The patients were divided into a control group (n=103), which received nedaplatin combined with paclitaxel liposomes, and an observation group (n=135), receiving nedaplatin combined with docetaxel. The treatment efficacy, adverse reactions, tumor biomarkers (CA125, CEA, HE4, and AFP), and inflammatory markers (TNF-α, IL-6) before and after treatment were compared between the two groups. Patients were followed up for 2 years to observe progression-free survival (PFS), and Kaplan-Meier survival curves were plotted and Logrank tests were performed to evaluate the 2-year PFS differences.</p><p><strong>Results: </strong>There were no significant differences in overall clinical efficacy or remission rates between the two groups post-treatment (both P>0.05). Both groups showed significant reductions in tumor biomarkers and inflammatory markers after treatment compared with pre-treatment levels (all P<0.05), and the differences between the groups after treatment were not significant (all P>0.05). The incidence of adverse reactions was also similar between the groups (P>0.05). Multivariate Cox regression analysis identified the treatment regimen (P<0.001), FIGO stage (P=0.005), maximum diameter of recurrent lesions (P=0.001), number of recurrent lesions (P<0.001), post-treatment CA125 (P<0.001), and post-treatment HE4 (P<0.001) as independent prognostic factors for PFS.</p><p><strong>Conclusions: </strong>The combination of nedaplatin with paclitaxel liposomes or docetaxel demonstrated comparable efficacy in ROC patients, effectively reducing tumor and inflammatory markers without increasing adverse reactions. Importantly, the combination of nedaplatin and docetaxel significantly improved PFS.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2484-2499"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of allylestrenol combined with ritodrine in treating preterm labour with preeclampsia and associated risk factors for pregnancy outcomes.","authors":"Junli Wang, Yan Hong, Diwu Yang, Hong Tao, Lin Sun","doi":"10.62347/YLHP2831","DOIUrl":"10.62347/YLHP2831","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the efficacy of diethylstilbestrol combined with ritodrine in treating preterm labor due to preeclampsia and to identify risk factors for different pregnancy outcomes.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 112 preterm pregnant women treated at Maanshan Maternal and Child Health Care Hospital from January 2022 to December 2023. Patients were divided into an observation group (n = 60) receiving allylestrenol tablets (10 mg daily, reduced to 5 mg after contractile reaction disappeared) and ritodrine injection (100 mg in 500 mL sedative, infused at 0.05-0.35 mg/min for 12-18 hours), and a control group (n = 52) treated with magnesium sulfate injection. Measured outcomes included symptom score, gestational age at delivery, treatment efficacy, adverse reactions, blood magnesium (MG), serum progesterone-induced blocking factor (PIBF), interleukin-6 (IL-6), cervical length (CL), and fetal fibronectin (fFN) levels.</p><p><strong>Results: </strong>The observation group had a significantly higher effective rate (78%) compared to the control group (54%, χ² = 9.73, P = 0.008). Adverse events occurred in 8% of the observation group versus 27% in the control group (χ² = 6.41, P = 0.011). Post-treatment symptom scores were lower in the observation group, with reduced preterm birth rates, higher gestational age, and increased neonatal weight. Premature births were associated with elevated IL-6 and fFN, reduced PIBF and CL, and lower MG levels. Logistic regression revealed higher PIBF reduced preterm birth risk, while increased IL-6 and fFN heightened the risk. ROC analysis identified PIBF as the best predictor of preterm birth.</p><p><strong>Conclusions: </strong>Allylestrenol combined with ritodrine is effective for managing preterm labor due to preeclampsia, improving maternal and fetal outcomes with good safety. This treatment warrants further clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3219-3227"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for persistent infection of high-risk HPV in patients with cervical intraepithelial neoplasia.","authors":"Juan Wang, Zan Tian, Jiaomin Wang","doi":"10.62347/GGVR2248","DOIUrl":"10.62347/GGVR2248","url":null,"abstract":"<p><strong>Objective: </strong>To identify the risk factors for persistent HR-HPV infection in patients with cervical intraepithelial neoplasia (CIN).</p><p><strong>Methods: </strong>A total of 312 patients with cervical intraepithelial neoplasia were followed up for six months. Among them, 164 patients with persistent HPV infection during re-examination were categorized into the persistent infection group, while 148 patients with negative HPV results were classified into the negative conversion group.</p><p><strong>Results: </strong>Multivariate logistic regression analyses identified the following independent risk factors for persistent HR-HPV infection: age ≥50 years (95% CI: 3.037-11.447; P<0.001), multiple HPV infections (95% CI: 4.250-18.417; P<0.001), HPV viral load ≥100 (95% CI: 1.529-5.673; P=0.001), reproductive tract inflammation (95% CI: 1.186-4.696; P=0.014), and thyroid dysfunction (95% CI: 8.346-17.207; P<0.001). A prediction model was developed based on the logistic regression analysis: Logit(P) = -102.56 + (age × 1.774) + (HPV multiple infections × 2.180) + (HPV viral load ≥100 × 1.080) + (reproductive tract inflammation × 0.859) + (thyroid dysfunction × 3.650). Receiver operating characteristic (ROC) curve analysis showed an area under the curve (AUC) of 0.800 for the model in predicting persistent high-risk HPV infection, with sensitivity of 81.00% and specificity of 79.46%.</p><p><strong>Conclusion: </strong>Age ≥50 years, multiple HPV infections, HPV viral load ≥100, reproductive tract inflammation, and thyroid dysfunction are independent risk factors for persistent high-risk HPV infection in patients with CIN.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2992-3000"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"H3K9me3 and H3K27me3 are epigenetic barriers to somatic cell nuclear transfer in rabbits.","authors":"Yuan Gao, Fangfang Wu, Dandan Tang, Xiao Chen, Qian Chen, Ying Chen, Kexin Fang, Wanxin Chen, Fuliang Du, Zhihui Liu","doi":"10.62347/FQYG9348","DOIUrl":"10.62347/FQYG9348","url":null,"abstract":"<p><p>Somatic cell nuclear transfer (NT) is associated with aberrant changes in epigenetic reprogramming that disrupt embryo development. Here, we characterized the epigenetic patterns of histone 3 lysine 9 trimethylation (H3K9me3) and histone 3 lysine 27 trimethylation (H3K27me3), the repressive histone signature in heterochromatin, in NT rabbit embryos. H3K9me3 modification was higher in all stages of NT vs. fertilized preimplantation embryos, consistent with decreased transcription of the H3K9me3 demethylase <i>KDM3B</i> in four-cell and eight-cell NT embryos vs. fertilized embryos. H3K27me3 was higher in NT embryos from two-cell stage to the blastocyst, and transcription of the H3K27me3 demethylase <i>KDM6A</i> was lower in four-cell and eight-cell NT embryos than in fertilized embryos. Cleavage under targets and tagmentation (CUT and Tag) showed enrichment of whole-chromosome H3K9me3 and H3K27me3 in four-cell and eight-cell NT vs. fertilized embryos. Further, eight-cell NT embryos had a higher proportion of H3K9me3 and H3K27me3 sites around the promoter regions of the genome compared to fertilized embryos. The genes associated with H3K9me3 sites near promoter regions were primarily related to the development of tissues and organs, whereas the H3K27me3 enriched regions mainly influenced the development and regulation of the nervous system. Our findings demonstrate that H3K9me3 and H3K27me3 inhibit the expression of genes essential for the development and preimplantation of NT embryos and, thus, are epigenetic barriers to NT reprogramming in rabbits.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3094-3108"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the diagnostic accuracy of lung cancer using endobronchial ultrasound-guided transbronchial needle aspiration.","authors":"Zhonghan Cai, Yinru Yuan, Zhiliang Zhou, Huo Ding, Yaoqiang Cheng, Li Liang, Zineng Tuo, Rongmei Zhou","doi":"10.62347/UIGU6267","DOIUrl":"10.62347/UIGU6267","url":null,"abstract":"<p><strong>Objectives: </strong>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a key diagnostic modality for lung cancer, yet its accuracy varies based on several factors. This study aims to identify factors influencing the diagnostic accuracy of EBUS-TBNA for lung cancer detection.</p><p><strong>Methods: </strong>A retrospective case-control study was conducted on lung cancer patients diagnosed at Gaozhou People's Hospital from October 2021 to September 2023. Patients with lung cancer confirmed by EBUS-TBNA, bronchoscopy with direct biopsy, or surgical intervention were re-evaluated using EBUS-TBNA. Based on diagnostic accuracy, they were classified into an accurate group (n = 204) and an inaccurate group (n = 41). An external validation cohort included 58 lung cancer patients. Data collection encompassed patient demographics and EBUS-TBNA findings. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to determine factors influencing detection accuracy. A generalized linear model incorporating independent influencing factors was developed to estimate the likelihood of inaccurate EBUS-TBNA detection of lung cancer.</p><p><strong>Results: </strong>Smoking history [dds ratio (OR), 7.948; <i>P</i> < 0.001] and a diagnosis of small cell lung cancer (OR, 3.996; <i>P</i> = 0.007) were significantly associated with an increased risk of inaccurate detection. In contrast, a lesion diameter of ≥ 3 cm (OR, 0.343; <i>P</i> = 0.026) and linear filamentous changes in aspirate samples (OR, 0.106; <i>P</i> < 0.001) were strongly correlated with accurate detection. Larger lesion size and specific sample characteristics were also significant predictors in the external validation cohort (<i>P</i> < 0.05). Multivariate logistic regression confirmed these factors as independent predictors of diagnostic accuracy. The predictive model demonstrated robust performance [area under the curve (AUC) = 0.882], with external validation yielding a comparable AUC of 0.877.</p><p><strong>Conclusion: </strong>Smoking history, pathologic subtype, lesion size and aspirate sample characteristics significantly affected the diagnostic accuracy of EBUS-TBNA in lung cancer detection. These insights underscore the importance of considering these factors in clinical practice to optimize EBUS-TBNA's diagnostic performance.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2690-2700"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relevance of B7-H3 and tumor-associated macrophages in the tumor immune microenvironment of solid tumors: recent advances.","authors":"Shuo Luan, Yuwei Zhao, Yiyang Yu, Jie Xu, Jiuhui Xu, Tingting Ren, Xiaodong Tang, Lu Xie","doi":"10.62347/ILTR3848","DOIUrl":"10.62347/ILTR3848","url":null,"abstract":"<p><p>B7 homolog 3 (B7-H3) is a member of the B7 ligand family. It is highly expressed in various human cancers, especially mesenchymal malignancies. B7-H3 regulates cancer progression through multiple signaling pathways such as JAK2/STAT3, NF-κB, PI3K/AKT, and ERK. It also has the ability to downregulate CD8⁺ T-cell infiltration and drive immune evasion. Tumor-associated macrophages (TAMs) are the primary immune infiltrating cells in diverse solid tumors, dominating the immune environment of these malignancies. B7-H3 may have connections to TAMs through the induction of polarization and immunosuppression by the CCL2-CCR2-M2 macrophage axis. This mechanism can inhibit antitumor immunotherapy and promote tumor progression in non-small cell lung cancer, ovarian cancer, colorectal cancer, and osteosarcoma. The inducibility of B7-H3 in TAMs provides novel insight into the targeting of checkpoints for tumor immunotherapy. In general, B7-H3 represents a promising immune therapeutic target and should be considered an immunologic adjuvant for activating the tumor immune microenvironment. Therefore, combination therapies based on anti-B7-H3 agents hold great potential for improving the solid tumor microenvironment to enhance the initiation of the cancer-immunity cycle.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2835-2849"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}