American journal of translational research最新文献

{"title":"MiR-193-3p suppresses phenotypic switching in vascular smooth muscle cells by regulating IGF2 during in-stent restenosis.","authors":"Tao Lv, Huan Zhang, Pingnian Yuan, Xiaowei Yang, Meng Wang, Tiantian Gou","doi":"10.62347/NZRN6858","DOIUrl":"10.62347/NZRN6858","url":null,"abstract":"<p><strong>Background: </strong>Dysregulated proliferation and migration of vascular smooth muscle cells (VSMCs) are central to the development of in-stent restenosis (ISR). Clinically, regulating VSMC phenotype during proliferation and migration presents a potential therapeutic approach to prevent IRS. However, the role of miR-193-3p in ISR pathogenesis remains largely uncharacterized.</p><p><strong>Objective: </strong>To investigate the role of miR-193-3p in ISR pathogenesis, focusing on the molecular mechanisms mediated by miR-193-3p, specifically the miR-193-3p/insulin-like growth factor-2 (IGF2) axis in regulating ISR.</p><p><strong>Methods: </strong>Serum levels of miR-193-3p were quantified in ISR patients and healthy controls using quantitative real-time polymerase chain reaction (qPCR). miR-193-3p mimic transfection in VSMCs was confirmed by qPCR. The phenotypic switching of VSMCs was assessed via qPCR and western blot. Proliferative and migratory activities were evaluated using CCK-8 and Transwell assays, respectively. IGF2 levels in VSMCs were assessed using qPCR and WB assays.</p><p><strong>Results: </strong>Serum levels of miR-193-3p were significantly reduced in ISR patients compared to healthy controls (P < 0.05). Overexpressing miR-193-3p markedly suppressed VSMC proliferation and migration (P < 0.05), while upregulating differentiation-associated VSMC markers at both mRNA and protein levels (P < 0.05). Mechanistically, IGF2 was identified as a direct target of miR-193-3p. Additionally, miR-193-3p expression was elevated in VSMCs following IGF2 stimulation (P < 0.05), and this upregulation counteracted IGF2-induced proliferative and migratory activity (P < 0.05).</p><p><strong>Conclusions: </strong>These findings suggest the miR-193-3p may serve as a potential biomarker for ISR and that targeting the miR-193-3p/IGF2 axis could be a promising strategy for managing ISR.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6291-6302"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the association between indoor environmental pollution and lung cancer risk in never-smokers.","authors":"Yan Hong, Kwang-Sim Jang, Haihui Xie","doi":"10.62347/MKBQ5855","DOIUrl":"10.62347/MKBQ5855","url":null,"abstract":"<p><strong>Objective: </strong>This review systematically evaluates the association between indoor environmental pollution and lung cancer risk in never-smokers by meta-analysis, providing evidence-based prevention strategies for lung cancer.</p><p><strong>Methods: </strong>This study was registered in PROSPERO (Registration No.: CRD420251008009) following the Preferred Reporting Items for Systematic Reviews and Meta - Analyses (PRISMA) guidelines. A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for relevant studies published from March 2005 to March 2025. Literature screening was conducted independently by two reviewers using a double-blind method. Study quality was assessed using the criteria recommended by the Agency for Healthcare Research and Quality (AHRQ). Meta-analysis was performed using STATA 12.0 and RevMan 5.3 software.</p><p><strong>Results: </strong>A total of 22 studies met the inclusion criteria. Analysis showed that indoor environmental pollutants, including residential radon (Odds Ratio [OR] = 1.82, 95% CI: 1.31-2.54), environmental tobacco smoke (ETS) (OR = 1.96, 95% CI: 1.36-2.82), cooking fumes (OR = 3.68, 95% CI: 2.67-5.07), cooking methods (deep-frying: OR = 1.60, 95% CI: 0.72-3.52; stir-frying: OR = 1.12, 95% CI: 1.07-1.17), and the use of solid fuels (OR = 5.54, 95% CI: 3.15-9.72) were all significantly associated with an increased risk of lung cancer in non-smoking populations. In addition, the study found that residential environmental pollution, occupational exposures, and low body mass index (BMI) were also significant factors for lung cancer in non-smoking patients.</p><p><strong>Conclusion: </strong>This study confirmed that indoor environmental pollutants, including residential radon, ETS, cooking fumes, specific cooking methods (deep-frying and stir-frying), and the solid fuel use, are significantly associated with an increased risk of lung cancer in non-smoking populations. Furthermore, exposure to outdoor pollutants in residential areas and occupational environments cannot be ignored.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"5779-5798"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct roles of extracellular vesicles derived from various mesenchymal stem cell sources in bone regeneration: a systematic review and meta-analysis.","authors":"Jieying Mai, Yanzhuang Ke, Yufan Yao","doi":"10.62347/WLNC8175","DOIUrl":"10.62347/WLNC8175","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis evaluated the therapeutic efficacy and underlying mechanisms of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in bone regeneration, with subgroup analyses based on EV source, dose, and delivery route.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Embase, and Web of Science (2015-2024) identified 2,414 records, of which 20 in vivo randomized controlled trials (RCTs) met the inclusion criteria. Data on animal models, EV sources, dosing, administration methods, and outcomes - including bone volume/total volume, histology, biomechanics - were extracted. Meta-analyses and subgroup comparisons were conducted using random-effects models.</p><p><strong>Results: </strong>MSC-EVs significantly promoted bone regeneration (pooled standardized mean difference [SMD]=2.17; 95% confidence interval: 2.08-2.25; P<0.00001). Local administration (n=15) and high-dose regimens (≥1×10¹⁰ particles/kg; n=16) were both effective (SMD=2.16 and 2.11, respectively). Subgroup analyses revealed consistent efficacy across EV sources. Rat models (n=13) yielded an SMD of 2.8, and RCTs (n=12) showed low heterogeneity (I²=25%) with an SMD of 2.9. Bone marrow-drived MSC-EVs (BMSC-EVs) exhibited superior osteogenic potential in critical-size defects; umbilical cord-drived MSC-EVs (UCMSC-EVs) showed anti-inflammatory and osteoprotective properties; and human-induced pluripotent stem cell-derived MSC-EVs (hiPS-MSC-EVs) supported multifunctional tissue repair. Sensitivity analyses confirmed result stability.</p><p><strong>Conclusion: </strong>MSC-EVs significantly enhance bone regeneration in a source-dependent manner: BMSC-EVs demonstrate superior efficacy in critical-size defects; UCMSC-EVs are effective in inflammatory osteolysis; hiPS-MSC-EVs support multifunctional tissue repair. Optimizing dosing (≥1×10¹⁰ particles/kg) and delivery strategies is essential for successful clinical translation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"5799-5813"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic action of the natural plant material icariin and its potential use in biomedical tissue engineering.","authors":"Jiawei Mi, Ying Yang, Xiang Zhu, Shuang Zheng, Jinrong Zhao","doi":"10.62347/LTGZ9375","DOIUrl":"10.62347/LTGZ9375","url":null,"abstract":"<p><p>Bone tissue regeneration remains a critical research focus in biomedical tissue engineering. Icariin, a flavonoid compound extracted from the medicinal herb <i>Epimedium</i>, has been traditionally used in Chinese medicine to treat bone-related disorders such as lumbago associated with kidney Yang deficiency, impotence, and musculoskeletal weakness. Recent advances in biomedical research have increasingly clarified its biological mechanisms, revealing that icariin can promote osteoblast proliferation and differentiation while simultaneously inhibiting osteoclast activity. However, current application of icariin in biomedical tissue engineering remains in the exploratory phase, with its molecular mechanisms not yet fully characterized. Moreover, the <i>in vivo</i> and <i>in vitro</i> evaluation systems for its therapeutic efficacy and safety remain to be optimized. A comprehensive investigation into icariin's osteogenic properties and its translational potential in biomedical tissue engineering are warranted. Such investigations may provide a theoretical basis and experimental evidence for developing novel bone repair materials and therapeutic strategies, offering substantial scientific significance and clinical application value.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"5814-5828"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning enables construction of a nomogram based on risk factors for adverse emotions in patients with diabetic foot infection.","authors":"Heng Du, Baoqin Meng, Shixing Ma, Chaochao Zhu, Wenchi Liu, Zhaoxia Wang","doi":"10.62347/ZWGQ9542","DOIUrl":"10.62347/ZWGQ9542","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors and construct a nomogram model using logistic regression to predict mood disturbance in patients with diabetic foot infection.</p><p><strong>Methods: </strong>We retrospectively analyzed 313 patients with diabetic foot infection who received treatment at our hospital between October 2020 and January 2023. Patients were grouped based on their post-treatment Self-Rating Anxiety Scale (SAS ≥50) and Self-Rating Depression Scale (SDS ≥53) scores into two groups: 134 patients with adverse mood and 179 with stable mood. The patients were divided into a test group (n=220) and a validation group (n=93) at a 7:3 ratio. Clinical data and laboratory indicators were collected to screen characteristic factors using four machine learning models. Common risk factors were screened using logistic regression, visualized, and incorporated into a nomogram. The clinical value, accuracy, and predictive value of the model were evaluated using receiver operating characteristic curves (ROCs), calibration curves, and decision curve analyses (DCAs).</p><p><strong>Results: </strong>Analysis identified Wagner classification, comorbidities, glycated hemoglobin (HbA1c), gender, and history of diabetes as common features across four machine learning models. Multifactorial logistic regression confirmed that Wagner classification, comorbidities, HbA1c, gender, and history of diabetes were independent risk factors for adverse mood in patients with diabetic foot infection. We constructed a nomogram based on the five characteristic factors. ROC curve analysis yielded an area under the curve (AUC) of 0.829, indicating high predictive accuracy for mood disturbances in the test group. Calibration curve and DCA analysis demonstrated the model's stability and clinical relevance, further supported by external validation.</p><p><strong>Conclusion: </strong>This study enhanced the predictive accuracy for mood disorders in patients with diabetic foot infections by leveraging machine learning to identify and visualize significant risk factors through a nomogram. This may be a valuable tool for clinical assessments and intervention.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6056-6067"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors in retroperitoneal liposarcoma after R0 resection: a study of age, histologic type, tumor stage, and differentiation grade.","authors":"Boyuan Zou, Xiaobing Chen, Haicheng Gao, Shibo Liu, Wenjie Li, Yingjiang Ye","doi":"10.62347/FQAD9826","DOIUrl":"10.62347/FQAD9826","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify prognostic factors affecting progression-free survival (PFS) in patients with retroperitoneal liposarcoma (RPLS) after R0 resection.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 183 RPLS patients who underwent R0 resection, evaluating general information, clinicopathological data, laboratory parameters, and follow-up outcomes. Based on follow-up outcomes, patients were categorized into progression-free survival (PFS) group (PFS, n=121) and disease progression group (DP, n=62). The general information, clinicopathological data, and laboratory parameters of the two groups were systematically compared, with statistically significant factors subsequently incorporated into the Cox multivariate regression analysis. Significant prognostic factors identified through Cox analysis were further evaluated using Kaplan-Meier (K-M) survival analysis, serving as the foundation for constructing the predictive model. The model's performance was rigorously assessed for 1-year, 3-year, and overall PFS prediction.</p><p><strong>Results: </strong>Multivariate analysis identified age (<i>HR</i>=1.034, 95% CI=1.011-1.057, <i>P</i>=0.003), histologic subtype (Well-differentiated liposarcoma as reference. Dedifferentiated liposarcoma: <i>HR</i>=0.130, 95% CI=0.029-0.578, <i>P</i>=0.007. Myxoid/round cell liposarcoma: <i>HR</i>=0.190, 95% CI=0.084-1.635, <i>P</i>=0.190. Pleomorphic liposarcoma: <i>HR</i>=0.176, 95% CI=0.036-0.865, <i>P</i>=0.032. Mixed-type liposarcoma: <i>HR</i>=0.793, 95% CI=0.157-4.008, <i>P</i>=0.799), tumor stage (<i>HR</i>=0.440, 95% CI=0.257-0.755, <i>P</i>=0.003), and tumor differentiation grade (<i>HR</i>=0.395, 95% CI=0.236-0.661, <i>P</i><0.001) as independent risk factors. The predictive models demonstrated excellent discriminative ability: 1-year model (AUC=0.944, NB=0.05-0.80), 3-year model (AUC=0.861, NB=0.05-0.73), the overall mode (AUC=0.903, NB=0.03-0.90).</p><p><strong>Conclusion: </strong>Advanced age, DDLPS, PLS, stage III-IV disease, and poor tumor differentiation were identified as independent predictors of shorter PFS in RPLS patients following R0 resection.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"5975-5986"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy and safety of carbon dioxide (CO₂) array laser versus erbium-doped yttrium aluminum garnet (Er:YAG) laser for acne scars.","authors":"Chang Xiao, Jun Zhang, Jing Peng","doi":"10.62347/WTMW1778","DOIUrl":"10.62347/WTMW1778","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a prevalent skin condition that often leads to facial scarring, significantly affecting patients' quality of life. Laser therapies, particularly carbon dioxide (CO₂) array laser and erbium-doped yttrium aluminum garnet (Er:YAG) laser, are widely used for acne scar management. This study aimed to compare the long-term efficacy and safety of these two laser systems for the treatment of acne scars.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 254 patients with acne scars who were treated between January 2021 and January 2024. Among them, 124 patients received CO₂ laser treatment, while 130 received Er:YAG laser treatment. Clinical data encompassing demographics, scar improvement, inflammatory markers, and patient satisfaction, were collected over one year. Evaluations were based on Extended Cook's Corrected Acne Scarring (ECCA) scores, VISIA Skin Analysis, and Dermatology Life Quality Index (DLQI).</p><p><strong>Results: </strong>Er:YAG laser demonstrated significantly lower intraoperative pain (VAS: 3.12 ± 0.23 vs. CO₂: 3.19 ± 0.21; P = 0.011) and shorter erythema resolution time (2.93 ± 0.64 vs. 3.11 ± 0.7 weeks; P = 0.029). Post-treatment INF-γ levels were higher in the Er:YAG group (853.68 ± 113.56 vs. 815.3 ± 120.28 pg/mL; P = 0.009). CO₂ laser showed superior long-term scar reduction (ECCA), with the most pronounced improvement observed at 12 months (39.84 ± 3.26 vs. Er:YAG: 41.31 ± 4.88; P = 0.005). VISIA analysis revealed better outcomes for CO₂ laser in pore size (7.55 ± 1.86 vs. 8.16 ± 1.14; P = 0.002) and porphyrins (81.33 ± 4.11 vs. 83.24 ± 5.24; P = 0.001). Treatment efficacy favored CO₂, with significantly lower ineffective response rates (5.65% vs. 16.92%; P = 0.017), although persistent erythema was more common with CO₂ (6.45% vs. 0.77%; P = 0.035). At 12 months, DLQI improvement was superior greater in the CO₂ group (11.25 ± 1.98 vs. 12.01 ± 2.02; P = 0.003).</p><p><strong>Conclusion: </strong>The CO₂ laser demonstrated superior long-term efficacy for reducing acne scars compared to the Er:YAG laser, at the cost of increased persistent erythema. Conversely, the Er:YAG laser offered a better recovery profile with fewer adverse reactions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6391-6402"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a logistic model and GBM model for infection after spinal canal resection of intraspinal tumors.","authors":"Yongqiang Ye, Jianwei Lv, Huan Liu, Fei Xie, Hongbin Liu","doi":"10.62347/DGJX1401","DOIUrl":"10.62347/DGJX1401","url":null,"abstract":"<p><strong>Objectives: </strong>To identify risk factors for postoperative infection following intraspinal tumor (IT) resection, and to construct predictive models using a Logistic regression model and gradient boosting machine (GBM) algorithms.</p><p><strong>Methods: </strong>A retrospective study was conducted on 136 patients who developed postoperative infections after IT resection at Ziyang Central Hospital from November 2013 to October 2024. Logistic regression and GBM models were developed using R 4.3.2.</p><p><strong>Results: </strong>Logistic regression analysis identified age >55 years, type II diabetes, operation time >3.3 h, interleukin-6 (IL-6)>5.5 ng/L, and procalcitonin (PCT)>0.3 ug/L as independent risk factors for infection after IT resection (<i>P</i><0.05). The logistic regression equation was: Logit (<i>P</i>) = -12.238 + 2.081 × Age + 1.118 × Type II diabetes + 1.381 × operation time + 2.131 × IL-6 + 1.843 × PCT. In the GBM model, the relative importance of variables was: age (23.13011), IL-6 (22.98775), type II diabetes (18.57776), PCT (17.86779), and operation time (17.73660). The areas under the ROC curves (AUC) was 0.886 for the logistic model and 0.907 for the GBM model. Calibration curves demonstrated good agreement between predicted and observed infection rates in both models.</p><p><strong>Conclusions: </strong>The identified risk factors and the predictive models offer valuable tools for early identification and prevention of postoperative infection following IT resection.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6425-6433"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial anomalous bands associated with arrhythmia detected by computed tomography during coronary CT angiography: a case series.","authors":"Yuqing Li, Jizhang Sheng, Jincai Wang","doi":"10.62347/EWIK6957","DOIUrl":"10.62347/EWIK6957","url":null,"abstract":"<p><p>False tendons are fibrous cord-like malformations within the cardiac chambers, with only approximately 2% occurring in the left atrium. In this study, we analyzed the clinical and imaging characteristics of multiple cases of left atrial false tendons (LAFTs) to provide additional clinical insights into this uncommon anatomical variant. A total of 10 representative LAFTs cases identified between September 2015 and June 2022 were included in this analysis. All patients were diagnosed using coronary computed tomographic angiography (CCTA). A retrospective analysis was performed using data retrieved from the Radiology Information System (RIS) and Picture Archiving and Communication System (PACS). Clinical history and electrocardiographic data were reviewed, and Xelis software was used for three-dimensional reconstruction to evaluate the morphology, anatomical position, and length of the LAFTs. Among the patients, eight exhibited arrhythmias: five had coarse, short longitudinal muscle bundles associated with atrial premature beats, while three had delicate longitudinal bundles accompanied by nonspecific T-wave abnormalities. The remaining two patients showed no specific symptoms or arrhythmic findings. Imaging analysis revealed that longitudinal and transverse muscle bundles measured approximately 2.5-3.0 cm and 3.5-4.4 cm in length, respectively, with attachments commonly located between the anterior and posterior walls of the left atrium or between the interatrial septum (near the fossa ovalis) and the lateral wall. A potential correlation between LAFTs and electrocardiographic abnormalities was observed. These findings suggest that LAFTs may be considered in the differential diagnosis when evaluating patients with unexplained arrhythmias undergoing CCTA.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6250-6256"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of the efficacy of an ultra-picosecond laser versus an ultra-pulsed CO₂ laser in the treatment of xanthelasma palpebrarum.","authors":"Jing Peng, Jun Zhang, Chang Xiao","doi":"10.62347/DETB5846","DOIUrl":"10.62347/DETB5846","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the efficacy and safety of the ultra-pulsed carbon dioxide (CO₂) laser and ultra-picosecond laser in managing Xanthelasma palpebrarum (XP).</p><p><strong>Methods: </strong>This retrospective study included 230 XP patients treated from February 2021 to June 2024. Among them, 120 patients received ultra-pulsed CO₂ laser treatment, and 110 received ultra-picosecond laser treatment. Treatment effectiveness was assessed based on lesion clearance rate, recurrence, Vancouver Scar Scale (VSS) scores, and safety profiles, with a focus on complications such as scarring and pigmentary changes.</p><p><strong>Results: </strong>Both lasers achieved high clearance rates (> 95%), with no significant difference between the two groups (83.33% in the ultra-pulsed CO₂ laser group vs. 80.00% in the ultra-picosecond laser group, P = 0.513). However, the ultra-picosecond group required more treatment sessions (4.74 ± 0.56 vs. 3.26 ± 1.32, P < 0.001) but had a lower recurrence rate (6.36% vs. 15.00%, P = 0.036). The ultra-pulsed CO₂ laser group showed a higher incidence of hypertrophic scarring (8.33% vs. 1.82%, P = 0.026) and pigmentary complications (hyperpigmentation: 11.67% vs. 2.73%, P = 0.010; hypopigmentation: 10.83% vs. 3.64%, P = 0.037). A significant difference in erythema incidence was also observed (40.00% vs. 27.27%, P = 0.042). Patient satisfaction levels with the two treatments were comparable (P > 0.05).</p><p><strong>Conclusions: </strong>Both laser therapies were effective in treating XP. However, the ultra-picosecond laser demonstrated superior safety, with fewer complications and lower recurrence rates, despite requiring more treatment sessions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"6442-6452"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}