American journal of translational research最新文献

{"title":"Antibacterial activity of local anesthetics against multidrug-resistant bacteria in vitro.","authors":"Jin Sol Lee, Jeongeun Moon, Joo Yong Lee, Hyeon Tae Kim, Sanghi Park, Jin-Wook Park, Young Duck Shin","doi":"10.62347/GKXF8390","DOIUrl":"10.62347/GKXF8390","url":null,"abstract":"<p><strong>Objectives: </strong>Local anesthetics are widely used in clinical settings for pain management. In addition to their analgesic effects, they may also exhibit antimicrobial properties. However, data on their activity against multidrug-resistant (MDR) pathogens are limited. This study aimed to evaluate the in vitro antibacterial activity of lidocaine, levobupivacaine, and bupivacaine against MDR bacteria, including Pseudomonas aeruginosa (MRPA), carbapenem-resistant Enterobacterales (CRE), and Acinetobacter baumannii (MRAB).</p><p><strong>Methods: </strong>The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each anesthetic were determined using the standardized broth microdilution method according to CLSI guidelines. Clinical isolates of MRPA, CRE, and MRAB were tested. Identification was performed using MALDI-TOF MS and VITEK II systems. The local anesthetics were diluted to clinically relevant concentrations and tested in duplicate.</p><p><strong>Results: </strong>Bupivacaine exhibited the strongest antimicrobial activity, with MICs of 1.6 mg/mL for MRAB and 3.2 mg/mL for CRE. Lidocaine showed limited activity, with an MIC of 16 mg/mL for MRPA. Levobupivacaine showed intermediate effects. In all cases, MBCs were higher than the corresponding MICs. These findings suggest differential antibacterial efficacy among the agents.</p><p><strong>Conclusions: </strong>Local anesthetics demonstrated measurable antibacterial effects against MDR pathogens in vitro. Bupivacaine showed the strongest activity but has a lower clinical dosage limit due to its cardiotoxicity. While lidocaine has weaker antibacterial potency, its widespread use and safety profile make it a practical option. These results suggest local anesthetics may play a complementary role in infection-prone procedures but require cautious interpretation for clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4774-4778"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined lung compliance and oxygenation dynamics predict high-flow nasal cannula failure in acute respiratory distress syndrome: a retrospective cohort study.","authors":"Huan Zhao, Ting Yao, Hong Liu","doi":"10.62347/ELGT2750","DOIUrl":"10.62347/ELGT2750","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the combined predictive value of lung compliance and dynamic oxygenation parameters for high-flow nasal cannula (HFNC) outcomes.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, 154 patients with acute respiratory distress syndrome (ARDS) treated with HFNC (flow ≥50 L/min, fraction of inspired oxygen [FiO₂] ≥0.5) between 2019 and 2022 were analyzed. Data collected included baseline characteristics, lung compliance (measured via mechanical ventilation or computed tomography [CT]), blood gas parameters-partial pressure of arterial oxygen to FiO₂ ratio (PaO₂/FiO₂) and its 24-hour change (ΔPaO₂/FiO₂) and clinical outcomes. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify predictors. A nomogram was constructed based on the regression model and validated using ROC curves and calibration plots.</p><p><strong>Results: </strong>Low baseline lung compliance (<30 mL/cmH₂O) was independently associated with HFNC failure (odds ratio [OR] =3.52, 95% confidence interval [CI]: 1.92-6.45, P<0.001), as was ΔPaO₂/FiO₂<20% at 24 hours (OR=2.84, 95% CI: 1.48-5.43, P=0.002). The combined model yielded superior predictive performance (area under the curve [AUC] =0.88) compared to lung compliance (AUC=0.82) or ΔPaO₂/FiO₂ alone (AUC=0.73). The nomogram demonstrated good calibration (Hosmer-Lemeshow test, P=0.41) and potential clinical utility. Patients with HFNC failure had longer ICU stays (median 14 vs. 7 days, P<0.001) and higher complication rates, including ventilator-associated pneumonia (34.8% vs. 8.3%, P<0.001) and barotrauma (10.9% vs. 1.9%, P=0.032).</p><p><strong>Conclusions: </strong>The combination of lung compliance and ΔPaO₂/FiO₂ improves early identification of HFNC failure and mortality risk, facilitating timely escalation to invasive ventilation. Prospective multicenter studies are needed to validate these findings.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4175-4186"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of the tumor microenvironment by Traditional Chinese Medicine: current progress and future perspectives in oncology.","authors":"Zhaohong Wang, Fei Wang, Yongjun Zhang","doi":"10.62347/NOAI4101","DOIUrl":"10.62347/NOAI4101","url":null,"abstract":"<p><p>The microenvironment in which tumor cells thrive constitutes a complex and dynamic system closely intertwined with tumors' occurrence, progression, metastasis, and drug resistance. As research in Traditional Chinese Medicine (TCM) for anticancer purposes advances, the holistic and multi-target regulatory principles of TCM have been proven highly suitable for modulating the tumor microenvironment (TME). Targeted therapy focusing on TME is poised to become a key area in future research on TCM's anticancer properties. This article provides an overview of TME characteristics and the current status of TCM's regulation of TME, offering insights into the application of TCM in anticancer research.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4071-4086"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a cardiovascular health score for diabetics based on the weighting of the contribution of diabetes-related mortality.","authors":"Xiaomeng Yang, Wanting Li, Suqing Wang","doi":"10.62347/OHVD7508","DOIUrl":"10.62347/OHVD7508","url":null,"abstract":"<p><strong>Background: </strong>Diabetes-related mortalities encompass multiple causes, including cardiovascular disease, infections, and diabetic nephropathy, with cardiovascular death being the leading cause among them. This study aimed to develop a cardiovascular health score specifically suited for diabetic patients based on the Life's Essential 8 scoring system.</p><p><strong>Methods: </strong>The study included 23,310 adults from the National Health and Nutrition Examination Survey (NHANES) and determined their mortality cause by linking the data to the National Death Index. The primary outcomes encompassed diabetes-related mortality, cardiovascular mortality, and all-cause mortality. Assessment of mortality risk by Cardiovascular Health (CVH) using cox proportional risk modeling. Weighted quantile sum regression models were utilized to evaluate the contributions of eight CVH factors within their combined effects. Based on the results, the contributions of each factor were adjusted to create a new CVH score. The X-tile figure was used to select the optimal threshold value for reclassifying CVH levels in diabetic patients. The C-index and Decision Curve Analysis were applied to compare the predictive performance of the new CVH level with the original CVH level.</p><p><strong>Results: </strong>Among the 23,310 adults who participated in the study, 15,217 were normoglycemic, 5,923 were prediabetic, and 2,170 were diabetic. Among the three glycemic states, diabetics exhibited the highest diabetes-related mortality rate (4.52%), and also had the highest cardiovascular mortality rate (3.09%). For all subjects, the risk of diabetes-related mortality decreased by 51.13% for every 10-point increase in the total CVH score, the most important CVH component was blood glucose (contribution of 64.6%). For diabetics, the most important CVH component was blood pressure (contribution of 35.7%), followed by tobacco/nicotine exposure and diet quality (contribution of 18.7% and 18.5%). Notably, the newly adjusted CVH score, unlike the original one, was significantly associated with cardiovascular death (HR = 0.9720, 95% CI: 0.9573 to 0.9869). We chose 30 and 60 as cutoff values for reclassifying CVH levels in diabetic patients. The DCA results indicated that the reclassified CVH levels were superior predictors of diabetes-related deaths, cardiovascular deaths, and all-cause mortality in diabetic patients compared to the original CVH levels.</p><p><strong>Conclusion: </strong>The weight-adjusted CVH score effectively predicted the risk of cardiovascular mortality in diabetics. The predictive performance of the reclassified CVH levels exhibited significant improvement over the original CVH levels. Additionally, when managing health, greater emphasis should be placed on encouraging diabetic patients to monitor their blood pressure, quit smoking, and maintain a healthy diet.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4562-4572"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine combined with propofol improves hemodynamic stability and recovery in elderly patients undergoing thoracoscopic lung cancer resection.","authors":"Yafeng Wang, Yalan Li","doi":"10.62347/XCOK4904","DOIUrl":"10.62347/XCOK4904","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of dexmedetomidine combined with propofol versus propofol alone on intraoperative hemodynamic stability and postoperative recovery in elderly patients undergoing thoracoscopic lung cancer resection.</p><p><strong>Methods: </strong>This retrospective comparative study included 123 patients aged ≥ 65 years scheduled for thoracoscopic lung cancer resection. Patients were divided into two groups: the dexmedetomidine-propofol group (observation group, n = 61) and the propofol-only group (control group, n = 62). Hemodynamic parameters - heart rate (HR), mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) - were recorded at predefined time points. Postoperative recovery times, stress and inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin-6 [IL-6]), adverse events, sedation scores, and pain scores were assessed. Multivariable regression and subgroup analyses were conducted to identify independent treatment effects and explore heterogeneity across patient subgroups.</p><p><strong>Results: </strong>The observation group demonstrated significantly more stable hemodynamic profiles, with lower HR, MAP, SBP, and DBP fluctuations across time points (all P < 0.05). Postoperative awakening and orientation recovery times were significantly shorter in the observation group (both P < 0.05). Levels of norepinephrine, epinephrine, TNF-α, and IL-6 were significantly lower postoperatively in the observation group (all P < 0.05). Incidences of respiratory depression and nausea/vomiting were also reduced (all P < 0.05). Multivariable analysis confirmed the independent benefit of the combined regimen. Subgroup analyses revealed greater efficacy in patients with ASA class II and those over 75 years of age.</p><p><strong>Conclusion: </strong>The combination of dexmedetomidine and propofol enhances intraoperative hemodynamic stability, accelerates recovery, reduces perioperative stress and inflammation, and lowers the incidence of adverse events in elderly patients undergoing thoracoscopic lung cancer resection. These results support its clinical value, particularly in high-risk subpopulations. Further studies are needed to refine dosing strategies and optimize safety.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4409-4420"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ultrasonic-assisted iRoot SP single-cone technique on root canal filling efficacy: an in vitro study.","authors":"Jun-Nan Li, He-Nan Yi, Fang-Nan Yang, Li Miao, Qi-Tao Du, Xiao-Pei Du","doi":"10.62347/WAIK7340","DOIUrl":"10.62347/WAIK7340","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare the sealing efficacy of three root canal filling techniques: AH plus with warm vertical compaction (WVC), iRoot SP with the single-cone technique, and ultrasonic-assisted iRoot SP single-cone technique.</p><p><strong>Methods: </strong>Ninety premolars extracted for orthodontic purposes at Dalian Stomatological Hospital between March 2022 and March 2024 were collected. After standardized root canal preparation, specimens were randomly assigned to three groups: AH plus group (WVC technique + AH plus), iRoot SP group (single-cone + iRoot SP), and US-iRoot SP group (ultrasonic-assisted single-cone + iRoot SP). Apical microleakage was assessed using dye leakage tests. Sealer penetration at 3 mm, 5 mm, and 8 mm from the apex was evaluated using optical microscopy and confocal laser scanning microscopy (CLSM). Stereomicroscopy and scanning electron microscopy (SEM) were used to analyze sealer distribution within the root canal.</p><p><strong>Results: </strong>The US-iRoot SP group exhibited significantly less apical microleakage than the AH plus and iRoot SP groups (P<0.05). CLSM analysis revealed significantly greater average and maximum sealer penetration depths in the US-iRoot SP group at all evaluated levels (P<0.05). Stereomicroscopy showed the smallest gap between sealer and gutta-percha in the US-iRoot SP group. SEM confirmed improved adaptation of the sealer to the dentin wall and deeper penetration into dentinal tubules.</p><p><strong>Conclusion: </strong>The ultrasonic-assisted iRoot SP single-cone technique significantly enhances root canal obturation quality compared to both the conventional iRoot SP single-cone technique and the AH plus with WVC technique.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4375-4386"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing weaning success from mechanical ventilation in Emergency department patients with acute respiratory failure.","authors":"Peng Huang, Fuguo Cao, Haibo Zhou, Zhuangzhi Xiong, Bo Chen, Hongping Hu","doi":"10.62347/ISME5144","DOIUrl":"10.62347/ISME5144","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the clinical and physiological factors associated with successful weaning from mechanical ventilation (MV) in patients with acute respiratory failure (ARF) treated in the Emergency department, and to evaluate their short-term prognosis.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 248 ARF patients who underwent MV in the Emergency department from July 2021 to June 2024. Patients were categorized into weaning success and failure groups based on their ability to maintain spontaneous breathing for over 48 hours post-extubation. Collected variables included demographic characteristics, body mass index, MV duration, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, blood gas parameters, and diaphragm function metrics. Multivariate logistic regression was used to identify independent predictors of weaning success.</p><p><strong>Results: </strong>Among the 248 patients, 165 (66.5%) were successfully weaned. Independent predictors of successful weaning included shorter MV duration, lower APACHE II scores, higher tidal volumes, and lower respiratory rates during spontaneous breathing trials. Diaphragmatic excursion was negatively associated with weaning failure, as was arterial oxygen partial pressure (PaO₂). Patients in the failure group had longer hospital stays and higher rates of complications, invasive interventions, and readmissions (all P<0.05).</p><p><strong>Conclusion: </strong>Weaning success in ARF patients managed in the Emergency department is influenced by a combination of clinical severity, ventilatory parameters, and diaphragm function. Recognition of these factors may aid in optimizing weaning strategies and improving patient prognosis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4622-4630"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota dysbiosis in alcoholic fatty liver disease: distinct microbial communities and biochemical alterations.","authors":"Xin Li, Fan Yang, Yuning Shi, Zheng Li, Zhuo Wang, Youqing Xu","doi":"10.62347/LDCH9386","DOIUrl":"10.62347/LDCH9386","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the gut microbiota composition among patients with alcoholic fatty liver disease (AFLD), individuals with alcohol use disorder (AUD) without liver damage, and healthy controls, and to investigate correlations between microbial profiles and liver health.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 34 participants: 14 with AFLD, 10 with AUD without liver damage, and 10 healthy controls. Blood biochemical markers, liver function tests, lipid profiles, and gut microbiota composition were assessed. Gut microbiota was analyzed via high-throughput 16S rRNA gene sequencing. Alpha and beta diversity indices were calculated, and group-specific microbial taxa were identified.</p><p><strong>Results: </strong>AFLD patients showed a decreased Firmicutes/Bacteroidetes ratio and an increased abundance of Bacteroidetes, indicating gut dysbiosis compared to the other groups. Biochemical markers, including triglycerides, alanine aminotransferase, gamma-glutamyl transferase, and cholinesterase, were significantly altered in AFLD patients (all P > 0.05). Beta diversity analysis revealed distinct microbial communities in the AFLD group. Notably, taxa such as Megamonas and Selenomonadales were enriched in AFLD, while beneficial genera like Ruminococcus and Faecalibacterium were significantly reduced.</p><p><strong>Conclusion: </strong>AFLD is associated with marked gut microbiota alterations and distinct microbial signatures, which correlate with liver dysfunction and biochemical abnormalities, highlighting the role of dysbiosis in disease pathogenesis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4213-4224"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and independent risk factors of lower extremity deep vein thrombosis in patients with acute carbon monoxide poisoning: a retrospective study.","authors":"Wuqiang Zhao, Zhenghui Yu, Qiuhong Shen, Xueping Zeng, Li Xu","doi":"10.62347/ILAC3174","DOIUrl":"10.62347/ILAC3174","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the incidence and independent risk factors of lower extremity deep vein thrombosis (DVT) in patients with acute carbon monoxide poisoning and to evaluate the predictive performance of a risk factor model to support early identification and individualized intervention for high-risk patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 180 patients diagnosed with acute carbon monoxide poisoning from January 2021 to December 2023. Lower extremity venous ultrasound was performed within 48 hours of admission to detect DVT, and patients were categorized into DVT and non-DVT groups. Clinical data - including demographic characteristics, poisoning-related variables, and biochemical markers - were collected and analyzed. Variables with statistical significance were subjected to logistic regression analysis to identify independent risk factors for DVT. Spearman correlation analysis and receiver operating characteristic (ROC) curve analysis were further conducted to assess variable relationships and the predictive performance of the risk model.</p><p><strong>Results: </strong>Among the 180 patients, 23 (12.78%) developed DVT. Spearman correlation analysis showed that coma duration, carboxyhemoglobin concentration, C-reactive protein, procalcitonin, D-dimer, creatinine, blood urea nitrogen, lactate dehydrogenase, myoglobin, and creatine kinase were positively correlated with DVT (all P < 0.001), whereas earlier initiation of hyperbaric oxygen therapy and higher albumin levels were negatively correlated (r = -0.397, P < 0.001). Logistic regression identified coma duration, D-dimer level, and carboxyhemoglobin concentration as independent risk factors for DVT. The ROC curve demonstrated good predictive performance, with an area under the curve of 0.888 (95% CI: 0.827-0.948, P < 0.05).</p><p><strong>Conclusion: </strong>Lower extremity DVT is relatively common in ptients with acute carbon monoxide poisoning. Coma duration, D-dimer levels, and delayed initiation of hyperbaric oxygen therapy are significantly associated with increased risk. The proposed risk factor model demonstrates strong predictive value and may assist in early clinical detection and targeted prevention strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4297-4305"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral congenital macular coloboma: a case report.","authors":"Chunyun Feng, Huimei Li","doi":"10.62347/EWSZ2426","DOIUrl":"10.62347/EWSZ2426","url":null,"abstract":"<p><p>Bilateral congenital macular coloboma is a rare condition, with only a few cases documented in the literature. We report a case of a 62-year-old woman who presented to Quzhou People's Hospital in January 2022 with complaints of dryness and foreign body sensation in both eyes, along with a history of lifelong poor vision. Her best-corrected visual acuity was 20/500 in the right eye and 20/400 in the left eye, with a spherical equivalent refractive error of -9.0 diopters bilaterally. Anterior segment examination was unremarkable; however, fundus examination revealed well-demarcated chorioretinal atrophic lesions approximately four disc diameters in size at the macula of both eyes. Optical coherence tomography (OCT) demonstrated a large excavation involving the retinal and choroidal layers beneath the fovea, consistent with a diagnosis of bilateral congenital macular coloboma. The patient was treated with sodium hyaluronate eye drops for dry eye symptoms, while the coloboma itself required no intervention. In patients with unexplained visual impairment, thorough fundus examination and high-resolution OCT imaging are essential for accurate diagnosis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4529-4533"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}