American journal of translational research最新文献

{"title":"Risk factors and development of a predictive model for frailty in patients with heart failure.","authors":"Huanliang Jin, Song Chen, Peichao Du, Jijie Xu, Hanying Zhou","doi":"10.62347/YMBE5232","DOIUrl":"10.62347/YMBE5232","url":null,"abstract":"<p><strong>Objectives: </strong>To identify factors influencing frailty in patients with heart failure (HF) and develop a predictive model for clinical use.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 350 HF patients at Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine between January 2020 and December 2023. Of these, 245 patients were allocated to the modeling group (n = 245) and 105 to the validation group (n = 105). In the modeling group, 135 patients were frail and 110 were non-frail. In the validation group, 47 patients were frail and 58 were non-frail. Logistic regression analysis was used to identify factors associated with frailty, and a nomogram was developed and validated to predict frailty risk.</p><p><strong>Results: </strong>Multivariate logistic regression analysis identified the following independent risk factors for frailty: fall history (OR: 0.101, 95% CI: 0.043-0.242, P < 0.001), advanced age (OR: 0.877, 95% CI: 0.828-0.928, P < 0.001), female sex (OR: 2.925, 95% CI: 1.294-6.613, P = 0.010), low hemoglobin levels (< 12 g/dL; OR: 2.547, 95% CI: 1.816-3.573, P < 0.001), and diabetes (OR: 3.202, 95% CI: 1.559-6.577, P = 0.002). Using these five variables, a nomogram was constructed to predict frailty risk, demonstrating an AUC of 0.822 (95% CI: 0.771-0.907).</p><p><strong>Conclusion: </strong>Fall history, advanced age, female sex, low hemoglobin levels, and diabetes are significant independent risk factors for frailty in HF patients. The nomogram prediction model demonstrated strong predictive performance, with high accuracy and clinical applicability.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3610-3618"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated true anterior thoracic meningocele associated with severe kyphoscoliosis: a case report.","authors":"He-Cheng Zhang, Quan-Shi, Xin Zhang, Wei-Xin Li","doi":"10.62347/SMEE7102","DOIUrl":"10.62347/SMEE7102","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal meningoceles are congenital anomalies characterized by meningeal herniation through vertebral defects, most commonly occurring in the lumbosacral region. Intrathoracic meningoceles are rare and are typically associated with neurofibromatosis type 1 (NF-1). True anterior thoracic meningoceles unassociated with NF-1 represent exceptionally rare clinical entities.</p><p><strong>Case summary: </strong>This is a retrospective case report. We report a 15-year-old female with severe kyphoscoliosis and a non-NF-1-associated anterior thoracic meningocele who presented with progressive spastic paraparesis. Imaging examinations revealed thoracolumbar scoliosis with 100-degree kyphotic angulation, midline anterior spina bifida at T7, and a well-defined cystic structure exhibiting hypointense T1 and hyperintense T2 signals (measuring 5.7×4.5 cm) anterior to the T7-T8 vertebral bodies. Surgical intervention included posterior spinal laminar decompression, T7 vertebral osteotomy, microscopic dural sac reduction, and stabilization using a pedicle screw system with autologous bone grafting. The patient was discharged without any complications 12 days after surgery, and at the 12-month follow-up, the patient achieved ambulation with a walker and leg brace.</p><p><strong>Conclusion: </strong>This case underscores the necessity of tailored surgical strategies for anterior thoracic meningoceles complicated by severe spinal deformities. The integration of microsurgical techniques and 3D-printed anatomical modeling may optimize procedural safety and functional outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3546-3553"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of complete remission in two patients with Barcelona stage C hepatocellular carcinoma treated with apatinib combined with camrelizumab.","authors":"Tao Zhang, Xing Wang, Ying Gao","doi":"10.62347/HWOV2961","DOIUrl":"10.62347/HWOV2961","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide. Due to its insidious onset and nonspecific clinical manifestations, most patients are diagnosed at an advanced stage and are no longer candidates for curative surgical resection. Treatment options for advanced HCC remain limited. Immunotherapy, particularly immune checkpoint inhibitors, in combination with anti-angiogenic agents, has emerged as a promising therapeutic strategy. Several studies have demonstrated the safety and efficacy of apatinib combined with camrelizumab in various solid tumors; however, complete remission is rarely reported. This report presents two cases of Barcelona Clinic Liver Cancer (BCLC) stage C HCC that achieved complete remission following treatment with apatinib plus camrelizumab. According to the Response Evaluation Criteria in Solid Tumors, both patients achieved complete response, allowing for drug discontinuation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3538-3545"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety analysis of ultrasound-guided radiofrequency ablation for varicose veins of lower extremities.","authors":"Ni Zhang, Haifeng Zhou, Yijiang Chen, Conghua Ding, Song Jiang","doi":"10.62347/RDKP4436","DOIUrl":"10.62347/RDKP4436","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of ultrasound-guided radiofrequency ablation (RFA) and high ligation and stripping (HL/S) for lower extremity varicose veins (VV).</p><p><strong>Methods: </strong>Clinical data from 160 VV patients treated at Hangzhou Fuyang Hospital of Traditional Chinese Medicine between January 2023 and December 2024 were retrospectively analyzed. Patients were assigned to either the RFA group (n = 82, ultrasound-guided RFA) or the HL/S group (n = 78, HL/S) based on the treatment modality. Operative time, intraoperative blood loss, length of stay (LOS), Visual Analogue Scale (VAS) scores, levels of bradykinin (BK), substance P (SP), plasminogen activator inhibitor-1 (PAI-1), fibrinogen (Fib), dorsal foot vein pressure, complication rates, and 1-month follow-up outcomes including 36-Item Short Form Survey (SF-36) scores and venous clinical severity scores (VCSS) were compared between the two groups.</p><p><strong>Results: </strong>The RFA group demonstrated shorter operative time, less blood loss, and shorter LOS compared to the HL/S group (<i>P</i> < 0.05). On postoperative days 1, 3, and 7, VAS scores were significantly lower in the RFA group compared to the HL/S group (<i>P</i> < 0.05). On postoperative day 7, levels of BK, SP, PAI-1, Fib, and dorsal foot vein pressure were significantly lower in the RFA group (<i>P</i> < 0.05). At 1-month follow-up, the RFA group showed a lower complication rate, higher SF-36 scores, and lower VCSS compared to the HL/S group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Ultrasound-guided RFA outperformed HL/S in reducing perioperative trauma, pain, dorsal foot vein pressure, and coagulation and inflammatory markers, while offering higher safety and improved short-term quality of life for VV patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3601-3609"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive role of inflammatory markers in characterizing the progression of interstitial lung disease: a retrospective analysis.","authors":"Delun Tan, Yaxue Shang, Jing Wang, Na Sheng","doi":"10.62347/JZTW5621","DOIUrl":"10.62347/JZTW5621","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the association between inflammatory markers and interstitial lung disease (ILD) progression in order to enhance disease monitoring and risk stratification.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed the clinical data from 172 ILD patients admitted to Nanjing Jiangbei Hospital between January 2021 and December 2023. Patients were categorized into two groups: progressive ILD (PILD; n=95) and rapidly progressive ILD (RPILD; n=77), based on changes in symptoms and pulmonary function within six months. PILD was defined by a ≥10% relative decline in predicted Forced Vital Capacity (ppFVC) or related clinical criteria. RPILD was defined by acute symptom worsening and significant pulmonary function deterioration. Inflammatory markers assessed included C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII).</p><p><strong>Results: </strong>CRP, NLR, PLR, and SII levels were significantly higher in the RPILD group, while LMR was significantly lower (all P<0.05). Multivariate logistic regression identified CRP, NLR, LMR, and SII as independent predictors of ILD progression. ROC analysis showed NLR had the highest individual predictive value (AUC=0.757). A composite model combining all five markers achieved an AUC of 0.842, indicating improved predictive accuracy.</p><p><strong>Conclusions: </strong>Inflammatory markers, particularly NLR, are independently associated with ILD progression. A composite model incorporating multiple markers offers enhanced predictive performance, potentially supporting clinical decision-making and early intervention strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3485-3495"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of erythrocyte sedimentation rate, albumin and CRP for infection risk in elderly rheumatoid arthritis patients undergoing treatment.","authors":"Ruoyan Li, Yizhou Xie, Kexin Lin, Xiaohong Fan","doi":"10.62347/VUDA3928","DOIUrl":"10.62347/VUDA3928","url":null,"abstract":"<p><strong>Objective: </strong>To develop a predictive model for infection risk in elderly rheumatoid arthritis (RA) patients using laboratory markers, particularly erythrocyte sedimentation rate (ESR), albumin (ALB), and C-reactive protein (CRP).</p><p><strong>Methods: </strong>This retrospective study included 452 elderly RA patients admitted to the Hospital of Chengdu University of Traditional Chinese Medicine between January 2021 and June 2024. The patients were randomly divided into a training group (271 patients) and a validation group (181 patients) at a 6:4 ratio. Key clinical and laboratory data were collected, including ESR, ALB, CRP, and others. Lasso regression and multivariable logistic regression were employed to identify infection-related factors. Model performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The study identified ALB<33.75 g/L, CRP≥32.75 mg/L, and ESR≥51.50 mm/h as independent risk factors for infection in elderly RA patients. A predictive model incorporating these three markers demonstrated high diagnostic accuracy, with an AUC of 0.909 in the training group and 0.880 in the validation group. DCA further confirmed the clinical utility of the model.</p><p><strong>Conclusions: </strong>This study successfully developed a predictive model combining ESR, ALB, and CRP to assess infection risk in elderly RA patients. This model has significant potential to enhance early infection detection and support clinical decision-making, offering a valuable tool for managing this vulnerable population.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3345-3356"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated KLF2 and YKL-40 with reduced vitamin A as predictive biomarkers for severity and prognosis in neonatal respiratory distress syndrome.","authors":"Feifei Jiang, Lipeng Sun","doi":"10.62347/ZNNV1969","DOIUrl":"10.62347/ZNNV1969","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationships between Krüppel-like factor 2 (KLF2), YKL-40, and vitamin A levels, as well as their association with the severity and prognosis of Neonatal Respiratory Distress Syndrome (NRDS), with the goal of improving predictive accuracy and clinical management.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at Bozhou Municipal People's Hospital between January 2019 and January 2022. A total of 128 neonates diagnosed with NRDS were included, along with 128 healthy neonates as controls. Blood samples were collected within one hour of admission. Levels of KLF2, YKL-40, and vitamin A were measured using enzyme-linked immunosorbent assay (ELISA) and high-performance liquid chromatography (HPLC). Neonates were grouped based on NRDS severity, and the relationships between biomarker levels and clinical outcomes were analyzed.</p><p><strong>Results: </strong>Significant differences in KLF2, YKL-40, and vitamin A levels were observed between the NRDS group and control group (<i>P</i> < 0.001). Elevated KLF2 and YKL-40 levels were strongly correlated with more severe disease, while lower vitamin A levels were associated with worse outcomes. Multivariate logistic regression identified KLF2, YKL-40, and vitamin A levels as independent predictors of NRDS severity (<i>P</i> < 0.05). The nomogram achieved a concordance index (C-index) of 0.93 (95% CI: 0.89-0.97), indicating excellent discrimination of different disease severity. Receiver's operating characteristic (ROC) curve analysis showed that combining these biomarkers improved the prediction of NRDS severity, with the joint model achieving an AUC of 0.95, sensitivity of 91.2%, and specificity of 90.1%.</p><p><strong>Conclusion: </strong>KLF2, YKL-40, and vitamin A are significant biomarkers for predicting the severity and prognosis of NRDS. Combining these biomarkers enhances predictive accuracy, aiding in the early identification and personalized management of neonates with NRDS.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3424-3434"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated levels of NT-proBNP, interferon-γ and tumor necrosis factor-α are associated with coronary artery injury in children with severe Kawasaki disease.","authors":"Dan Li, Wenjing Zhang, Huiqing Feng, Man Li, Jing Zhao, Yanpeng Xu, Yanping Liu","doi":"10.62347/AJMB5384","DOIUrl":"10.62347/AJMB5384","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between N-terminal pro-brain natriuretic peptide (NT-proBNP), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and coronary artery injury in children with Kawasaki disease (KD).</p><p><strong>Methods: </strong>This retrospective study included 42 children with KD admitted to Baoding Hospital of Beijing Children's Hospital Capital Medical University from January 2019 to January 2022 (KD group), and 80 healthy children during the same period (control group). Peripheral blood markers including white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT), mean platelet volume (MPV), platelet distribution width (PDW), platelet count (PLT), NT-proBNP, IFN-γ, TNF-α, C-reactive protein (CRP), and circulating endothelial cell count (CEC) were compared between groups. KD patients were further stratified based on the severity of coronary artery involvement for subgroup analysis.</p><p><strong>Results: </strong>Compared with the control group, the KD group showed significantly higher levels of WBC, PDW, PLT, NT-proBNP, IFN-γ, TNF-α, CRP, and CEC, and significantly lower levels of RBC, Hb, and HCT (all P < 0.05). MPV levels did not differ significantly between groups (P > 0.05). Among the 42 KD patients, 17 had coronary artery involvement. These patients exhibited significantly higher levels of PDW, NT-proBNP, IFN-γ, TNF-α, CRP, and CEC compared to those without coronary artery injury (all P < 0.05). There were no significant differences in WBC, RBC, Hb, HCT, MPV, or PLT between the KD subgroups with and without coronary artery lesions (all P > 0.05). The diagnostic sensitivity of NT-proBNP, IFN-γ, and TNF-α for coronary artery injury in KD was 96.18%, 83.47%, and 65.20%, respectively, with specificities of 78.71%, 82.16%, and 81.98%, respectively. The area under the ROC curve for NT-proBNP, IFN-γ, and TNF-α was 0.969, 0.875, and 0.704, respectively. Logistic regression analysis identified elevated IFN-γ, TNF-α, CRP, and CEC as independent risk factors for coronary artery injury in children with KD (all P < 0.05).</p><p><strong>Conclusions: </strong>NT-proBNP, IFN-γ, and TNF-α levels are significantly elevated in children with severe KD and are closely associated with coronary artery injury. These biomarkers may serve as early predictors of coronary artery complications in KD.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3683-3690"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum dual-branch neural networks with transfer learning for early detection of skin cancer.","authors":"Yuyang Sun, Xing Deng, Haijian Shao","doi":"10.62347/WOHQ8174","DOIUrl":"10.62347/WOHQ8174","url":null,"abstract":"<p><strong>Background: </strong>Accurate classification of skin cancer is critical for early detection and timely treatment, significantly improving patient survival rates. While quantum neural networks combined with transfer learning show promise in medical image analysis, quantum noise remains a major challenge, compromising the stability and reliability of these systems. This study aims to address this limitation by developing a robust quantum-based framework for skin cancer classification.</p><p><strong>Methods: </strong>We propose a Quantum Dual-Branch Neural Network (QDBNN) that employs two independently trained network branches without shared weights. Dual-modal features are fused at the fully connected layer, and a Variational Quantum Classifier (VQC) is utilized for final classification. The model is evaluated on two datasets: the multiclass HAM10000 and the binary Malignant vs. Benign dataset.</p><p><strong>Results: </strong>QDBNN achieved state-of-the-art accuracies of 93.6% on HAM10000 and 93.5% on the Malignant vs. Benign dataset, outperforming classical and quantum transfer learning baselines. The dual-branch architecture and weighted feature fusion demonstrated enhanced robustness against quantum noise while improving generalization.</p><p><strong>Conclusion: </strong>QDBNN effectively mitigates quantum noise interference and leverages quantum-classical hybrid advantages for skin cancer classification. Its success highlights the potential of quantum-inspired architectures in medical imaging, offering a pathway toward clinically deployable tools for early diagnosis. Future work will focus on hardware optimization and scalability to larger datasets.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3357-3367"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link between non-alcoholic fatty liver disease and depression: a systematic review and meta-analysis of bidirectional risk.","authors":"Lan Mou, Hongfang Yao","doi":"10.62347/XLVA5738","DOIUrl":"10.62347/XLVA5738","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to consolidate evidence regarding the occurrence of depression among non-alcoholic fatty liver disease (NAFLD) patients and explore the bidirectional relationship between NAFLD and depression.</p><p><strong>Methods: </strong>Three major databases: Medline, Google Scholar, and ScienceDirect, were searched for relevant studies published up to August 2023 that report the incidence of depression in patients with NAFLD and investigate a correlation between NAFLD and depression. The quality of the studies was evaluated using the Joanna Briggs Institute checklist. The final pooled prevalence was reported with a 95% confidence interval (CI), and the pooled incidence of depression among NAFLD patients was summarized as a pooled Odds ratios (OR) with a 95% CI.</p><p><strong>Results: </strong>A total of 16 studies were included in the analysis. The pooled prevalence of depression (15 studies) among NAFLD patients was 19% (95% CI: 16%-22%) (<i>P</i>-value < 0.001). Patients with NAFLD had a 28%-increased risk (OR 1.28, 95% CI: 1.06-1.55, <i>P</i>-value < 0.001) of developing depression compared to non-NAFLD patients (10 studies). Conversely, patients with depression had 2.32 times higher odds (OR 2.32, 95% CI: 1.13-4.78, <i>P</i>-value 0.03) of developing NAFLD (two studies). Subgroup analyses based on sample size and geographic region revealed variations in prevalence estimates.</p><p><strong>Conclusion: </strong>Robust evidence supported a bidirectional link between NAFLD and depression. These findings underscore the importance of comprehensive patient care strategies that encompass both physical and mental well-being.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3691-3702"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}