{"title":"R0切除术后腹膜后脂肪肉瘤的预后因素：年龄、组织学类型、肿瘤分期和分化等级的研究。","authors":"Boyuan Zou, Xiaobing Chen, Haicheng Gao, Shibo Liu, Wenjie Li, Yingjiang Ye","doi":"10.62347/FQAD9826","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify prognostic factors affecting progression-free survival (PFS) in patients with retroperitoneal liposarcoma (RPLS) after R0 resection.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 183 RPLS patients who underwent R0 resection, evaluating general information, clinicopathological data, laboratory parameters, and follow-up outcomes. Based on follow-up outcomes, patients were categorized into progression-free survival (PFS) group (PFS, n=121) and disease progression group (DP, n=62). The general information, clinicopathological data, and laboratory parameters of the two groups were systematically compared, with statistically significant factors subsequently incorporated into the Cox multivariate regression analysis. Significant prognostic factors identified through Cox analysis were further evaluated using Kaplan-Meier (K-M) survival analysis, serving as the foundation for constructing the predictive model. The model's performance was rigorously assessed for 1-year, 3-year, and overall PFS prediction.</p><p><strong>Results: </strong>Multivariate analysis identified age (<i>HR</i>=1.034, 95% CI=1.011-1.057, <i>P</i>=0.003), histologic subtype (Well-differentiated liposarcoma as reference. Dedifferentiated liposarcoma: <i>HR</i>=0.130, 95% CI=0.029-0.578, <i>P</i>=0.007. Myxoid/round cell liposarcoma: <i>HR</i>=0.190, 95% CI=0.084-1.635, <i>P</i>=0.190. Pleomorphic liposarcoma: <i>HR</i>=0.176, 95% CI=0.036-0.865, <i>P</i>=0.032. Mixed-type liposarcoma: <i>HR</i>=0.793, 95% CI=0.157-4.008, <i>P</i>=0.799), tumor stage (<i>HR</i>=0.440, 95% CI=0.257-0.755, <i>P</i>=0.003), and tumor differentiation grade (<i>HR</i>=0.395, 95% CI=0.236-0.661, <i>P</i><0.001) as independent risk factors. The predictive models demonstrated excellent discriminative ability: 1-year model (AUC=0.944, NB=0.05-0.80), 3-year model (AUC=0.861, NB=0.05-0.73), the overall mode (AUC=0.903, NB=0.03-0.90).</p><p><strong>Conclusion: </strong>Advanced age, DDLPS, PLS, stage III-IV disease, and poor tumor differentiation were identified as independent predictors of shorter PFS in RPLS patients following R0 resection.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 8","pages":"5975-5986"},"PeriodicalIF":1.6000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432759/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prognostic factors in retroperitoneal liposarcoma after R0 resection: a study of age, histologic type, tumor stage, and differentiation grade.\",\"authors\":\"Boyuan Zou, Xiaobing Chen, Haicheng Gao, Shibo Liu, Wenjie Li, Yingjiang Ye\",\"doi\":\"10.62347/FQAD9826\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to identify prognostic factors affecting progression-free survival (PFS) in patients with retroperitoneal liposarcoma (RPLS) after R0 resection.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 183 RPLS patients who underwent R0 resection, evaluating general information, clinicopathological data, laboratory parameters, and follow-up outcomes. Based on follow-up outcomes, patients were categorized into progression-free survival (PFS) group (PFS, n=121) and disease progression group (DP, n=62). The general information, clinicopathological data, and laboratory parameters of the two groups were systematically compared, with statistically significant factors subsequently incorporated into the Cox multivariate regression analysis. Significant prognostic factors identified through Cox analysis were further evaluated using Kaplan-Meier (K-M) survival analysis, serving as the foundation for constructing the predictive model. The model's performance was rigorously assessed for 1-year, 3-year, and overall PFS prediction.</p><p><strong>Results: </strong>Multivariate analysis identified age (<i>HR</i>=1.034, 95% CI=1.011-1.057, <i>P</i>=0.003), histologic subtype (Well-differentiated liposarcoma as reference. Dedifferentiated liposarcoma: <i>HR</i>=0.130, 95% CI=0.029-0.578, <i>P</i>=0.007. Myxoid/round cell liposarcoma: <i>HR</i>=0.190, 95% CI=0.084-1.635, <i>P</i>=0.190. Pleomorphic liposarcoma: <i>HR</i>=0.176, 95% CI=0.036-0.865, <i>P</i>=0.032. Mixed-type liposarcoma: <i>HR</i>=0.793, 95% CI=0.157-4.008, <i>P</i>=0.799), tumor stage (<i>HR</i>=0.440, 95% CI=0.257-0.755, <i>P</i>=0.003), and tumor differentiation grade (<i>HR</i>=0.395, 95% CI=0.236-0.661, <i>P</i><0.001) as independent risk factors. The predictive models demonstrated excellent discriminative ability: 1-year model (AUC=0.944, NB=0.05-0.80), 3-year model (AUC=0.861, NB=0.05-0.73), the overall mode (AUC=0.903, NB=0.03-0.90).</p><p><strong>Conclusion: </strong>Advanced age, DDLPS, PLS, stage III-IV disease, and poor tumor differentiation were identified as independent predictors of shorter PFS in RPLS patients following R0 resection.</p>\",\"PeriodicalId\":7731,\"journal\":{\"name\":\"American journal of translational research\",\"volume\":\"17 8\",\"pages\":\"5975-5986\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432759/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of translational research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.62347/FQAD9826\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/FQAD9826","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Prognostic factors in retroperitoneal liposarcoma after R0 resection: a study of age, histologic type, tumor stage, and differentiation grade.
Objective: This study aimed to identify prognostic factors affecting progression-free survival (PFS) in patients with retroperitoneal liposarcoma (RPLS) after R0 resection.
Methods: A retrospective analysis was conducted on 183 RPLS patients who underwent R0 resection, evaluating general information, clinicopathological data, laboratory parameters, and follow-up outcomes. Based on follow-up outcomes, patients were categorized into progression-free survival (PFS) group (PFS, n=121) and disease progression group (DP, n=62). The general information, clinicopathological data, and laboratory parameters of the two groups were systematically compared, with statistically significant factors subsequently incorporated into the Cox multivariate regression analysis. Significant prognostic factors identified through Cox analysis were further evaluated using Kaplan-Meier (K-M) survival analysis, serving as the foundation for constructing the predictive model. The model's performance was rigorously assessed for 1-year, 3-year, and overall PFS prediction.
Results: Multivariate analysis identified age (HR=1.034, 95% CI=1.011-1.057, P=0.003), histologic subtype (Well-differentiated liposarcoma as reference. Dedifferentiated liposarcoma: HR=0.130, 95% CI=0.029-0.578, P=0.007. Myxoid/round cell liposarcoma: HR=0.190, 95% CI=0.084-1.635, P=0.190. Pleomorphic liposarcoma: HR=0.176, 95% CI=0.036-0.865, P=0.032. Mixed-type liposarcoma: HR=0.793, 95% CI=0.157-4.008, P=0.799), tumor stage (HR=0.440, 95% CI=0.257-0.755, P=0.003), and tumor differentiation grade (HR=0.395, 95% CI=0.236-0.661, P<0.001) as independent risk factors. The predictive models demonstrated excellent discriminative ability: 1-year model (AUC=0.944, NB=0.05-0.80), 3-year model (AUC=0.861, NB=0.05-0.73), the overall mode (AUC=0.903, NB=0.03-0.90).
Conclusion: Advanced age, DDLPS, PLS, stage III-IV disease, and poor tumor differentiation were identified as independent predictors of shorter PFS in RPLS patients following R0 resection.
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