American journal of translational research最新文献

{"title":"Value of a multi-indicator model combining Elast PQ technology, blood lipids, liver function, and uric acid for early diagnosis of alcoholic fatty liver disease.","authors":"Linlin Yue, Linlin Sun, Nan Li","doi":"10.62347/GMGX5873","DOIUrl":"10.62347/GMGX5873","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate a risk prediction model for alcoholic fatty liver disease (AFLD) based on clinical characteristics and liver stiffness measurements.</p><p><strong>Methods: </strong>This retrospective cohort study included 148 AFLD patients and 148 healthy controls from a tertiary hospital between January 2018 and December 2023. Participants underwent biochemical tests (lipid profile, liver function, uric acid) and liver stiffness measurements using Elastography Protocol for Quantification (Elast PQ). The external validation cohort, was from another hospital, with data collected from May 2019 to December 2023. It included 90 patients diagnosed with AFLD and 90 healthy controls. Machine learning methods (random forest, support vector machine, logistic regression) were employed to compare model performance. Logistic regression was used to identify predictive factors. Model performance was evaluated using Receiver Operating Characteristic (ROC) curve analysis, confusion matrices, calibration curves, and Decision Curve Analysis (DCA).</p><p><strong>Results: </strong>Univariate analysis revealed significant associations between body mass index (BMI), alcohol consumption, blood lipids, and liver function with AFLD (P < 0.001). Multivariate analysis identified high-aensity lipoprotein (HDL) (P = 0.041), alanine aminotransferase (ALT) (P = 0.007), and Elast PQ (P = 0.038) as independent risk factors. The logistic regression model showed an area under the curve (AUC) of 0.81 in the training set, 0.67 in the validation set, and 0.79 in the external validation cohort. The optimal cutoff value of 0.403 maximized sensitivity (0.62) and specificity (0.69), with an accuracy of 0.66. DCA indicated a high clinical net benefit. The risk prediction score enables rapid AFLD risk assessment and demonstrates strong predictive ability.</p><p><strong>Conclusions: </strong>The AFLD risk prediction model, based on clinical features and liver stiffness assessment, exhibits strong predictive power and significant clinical value for early diagnosis and management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3050-3062"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenosine receptor subtype modulators: Insight into molecular mechanisms and their therapeutic application.","authors":"Nilay Solanki, Rohinee Dodiya, Dhruvi Vejpara, Smruti Azad, Mehul Patel, Swayamprakash Patel, Umang Shah, Arun Soni, Rajesh Maheshwari, Archana Navale, Ashish Patel, Sandip Patel, Devang Sheth, Pravin Tirgar, Rachana R","doi":"10.62347/ZYVY9443","DOIUrl":"10.62347/ZYVY9443","url":null,"abstract":"<p><p>There are four different subtypes of adenosine receptors (ARs): A1, A2A, A2B, and A3. These receptors play a role in controlling healthy and unhealthy processes related to protecting neurons, inflammation, heart health, and the growth of cancer. The A1 receptors protect neurons and the heart, while the A2A receptors play a role in treating Parkinson's disease and cancer immunotherapy. Although much less abundant than A2A receptors, they are linked to asthma and diabetes, while the A3 receptors are promising targets for autoimmune diseases and cancer. Recent research has shown that agonists and antagonists that are specific to AR can be used as medicines by changing important biological pathways. A2A antagonists, A3 agonists, and other related compounds are being tested in people with heart failure, ischemia, neurodegenerative diseases, and inflammatory disorders. However, the main problem with this is the side effects, which include heart damage, low receptor selectivity, and drug responses that are specific to certain species. In the future, scientists need to find ways to make receptor-specific ligands that work better as medicines and have fewer side effects. Current advances include selective drugs for glaucoma, asthma, and oncology, as well as new approaches for neurodegenerative diseases and chronic inflammation. With these challenges addressed, AR therapies can transform the treatment landscape of complex conditions. This review covers the molecular mechanisms, tissue-specific roles, and translational progress of AR subtypes and further advocates for ongoing innovation to optimally tailor the clinical outcome of such interventions. Therefore, unlocking the full therapeutic potential of changing the AR could lead to new ways of treating a wide range of short-term and long-term illnesses.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2376-2395"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of transvaginal erbium laser treatment for vaginal relaxation and its impact on vaginal microenvironment indicators.","authors":"Yanwen Qi, Cheng Sun, Yang Zhou, Lizhou Luo, Chengyuan Wang","doi":"10.62347/BVZV3932","DOIUrl":"10.62347/BVZV3932","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of transvaginal erbium laser therapy in the treatment of Vaginal Relaxation Syndrome (VRS) and its effects on key indicators of vaginal health.</p><p><strong>Methods: </strong>This retrospective study analyzed clinical data from women treated for VRS at the China-Japan Friendship Hospital. Participants were divided into two groups: laser therapy (n = 130) and estrogen treatment (n = 112). Demographic characteristics, clinical outcomes, vaginal microenvironment parameters, and sexual function were assessed. Primary outcomes included changes in pelvic floor muscle strength, vaginal atrophy scores, vaginal pH, lactobacilli grades, and sexual satisfaction.</p><p><strong>Results: </strong>At the three-month follow-up, the laser group showed significant improvement in pelvic floor muscle strength (P = 0.046) and reductions in vaginal atrophy scores (P = 0.035) compared to the estrogen group. Additionally, patients in the laser group reported greater sexual satisfaction, including increased orgasm frequency (P = 0.007). While improvements in lactobacilli grades and vaginal pH were observed in the laser group, these changes were not statistically significant (both P > 0.05). Adverse reactions were mild and occurred less frequently in the erbium laser group (P < 0.05).</p><p><strong>Conclusion: </strong>Transvaginal erbium laser therapy is an effective intervention for alleviating VRS symptoms and enhancing pelvic floor muscle function. It also contributes to improved sexual satisfaction and supports the maintenance of a healthy vaginal microenvironment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2701-2711"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of uric acid and lipid levels with preeclampsia and final pregnancy outcome in late pregnancy.","authors":"Liqin Dong, Wei Li, Xi Niu, Lixia Luan, Shuning Hui","doi":"10.62347/HBLW4532","DOIUrl":"10.62347/HBLW4532","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between uric acid (UA), lipid levels, and preeclampsia (PE), as well as their effect on pregnancy outcome in women in late pregnancy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data from 126 pregnant women with PE who were admitted to the First Affiliated Hospital of Xi'an Medical University from June 2021 to January 2024 (research group). Additionally, clinical data from 130 healthy pregnant women who gave birth during the same period were served as controls. General information, UA levels, blood lipid levels [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFA), lipoprotein-a (Lp-a), apolipoprotein-a1 (ApoA1), apolipoprotein B (ApoB), LDL-C/HDL-C, and ApoA1/ApoB] and pregnancy outcomes were compared between the two groups. A logistic regression model was used to identify the influencing factors for PE. The predictive value of UA and lipid levels for PE diagnosis and prognosis was evaluated using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>No significant differences were observed between the groups in terms of age, parity, mode of delivery, neonatal gender, gestational cardiac disease, HDL-C, FFA, ApoA1, or ApoA1/ApoB (all P>0.05). However, the research group exhibited significantly higher body mass index (BMI), prevalence of gestational diabetes, and gestational hypertension, UA, TC, TG, LDL-C, Lp-a, ApoB, and LDL-C/HDL-C ratio compared to the control group, but lower neonatal weight (all P<0.05). Furthermore, the research group had a higher incidence of gestational diabetes, gestational hypertension, postpartum hemorrhage, fetal growth retardation, preterm delivery, and neonatal asphyxia (all P<0.05). Multivariate logistic regression analysis identified BMI, neonatal weight, UA, TC, TG, and LDL-C as independent influencing factors for PE. ROC curve analysis demonstrated high diagnostic accuracy for BMI (AUC=0.835), neonatal weight (AUC=0.755), UA (AUC=0.765), TC (AUC=0.706), and LDL-C (AUC=0.792) in predicting PE.</p><p><strong>Conclusion: </strong>Maternal BMI, neonatal weight, serum UA, TC, TG, and LDL-C levels are risk factors for the development of PE. Among these, BMI, neonatal weight, serum UA, TC, and LDL-C levels have a high predictive value for PE and can serve as valuable indicators for its early prediction and management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2800-2808"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dyadic coping-based couple psychological intervention on preoperative anxiety and postoperative pain in ectopic pregnancy patients.","authors":"Si Chen, Xinyu Yang, Lichan Song, Kejia Sha","doi":"10.62347/ZCHN5990","DOIUrl":"10.62347/ZCHN5990","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of dyadic coping-based couple psychological intervention on preoperative anxiety and postoperative pain in ectopic pregnancy patients.</p><p><strong>Methods: </strong>A retrospective study was conducted with 100 ectopic pregnancy patients from Wuhan Children's Hospital between January 2022 and April 2024. Participants were divided into two groups: 50 in the control group (standard psychological intervention) and 50 in the observation group (dyadic coping-based psychological intervention). Outcomes were assessed using the State-Trait Anxiety Inventory (STAI), Connor-Davidson Resilience Scale (CD-RISC), Visual Analog Scale (VAS), Self-Rating Depression Scale (SDS), and Short Form-36 (SF-36). Data analysis was performed using SPSS 27.0.</p><p><strong>Results: </strong>The observation group exhibited significantly higher CD-RISC and lower STAI scores (both P < 0.001) compared to the control group. SDS scores were also lower in the observation group (P = 0.044). Postoperative VAS scores and SF-36 scores (both P < 0.05) were significantly improved in the observation group at days 1, 3, and 7. Complication rates were lower in the observation group (2% vs. 18%, P = 0.008). Correlation analysis revealed higher postoperative CD-RISC scores (rho = 0.411, P < 0.001) and lower S-AI (rho = -0.297, P = 0.003), T-AI scores (rho = -0.498, P < 0.001) and SDS scores (rho = -0.217, P = 0.030) were associated with better recovery. A higher complication rate was negatively correlated with recovery (rho = -0.267, P = 0.007), while better physical functioning (PF) (rho = 0.227, P = 0.023) was positively correlated with recovery.</p><p><strong>Conclusion: </strong>Dyadic coping-based couple psychological intervention reduces preoperative anxiety and postoperative pain in ectopic pregnancy patients, enhances psychological resilience, and improves quality of life, fostering better health outcome and recovery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2642-2653"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and influencing factors of thrombolytic therapy in patients with pulmonary embolism complicated y pulmonary arterial hypertension.","authors":"Hui Wei, Jingsong An, Haijun Yin, Huizhao Liu, Fang Sun, Yanli Wang, Jie Cao","doi":"10.62347/RJDR4749","DOIUrl":"10.62347/RJDR4749","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the therapeutic efficacy of thrombolysis in patients with pulmonary embolism (PE) and pulmonary hypertension (PH), and identify factors influencing therapeutic outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 148 patients diagnosed with PE complicated by PH who received thrombolytic treatment at Tianjin Medical University General Hospital and Inner Mongolia People's Hospital between January 2022 and August 2024. Changes in inflammatory markers, blood gas parameters, and coagulation function indicators before and after treatment were compared, and the overall treatment efficacy rate was calculated. Patients were stratified based on therapeutic response, and a binary logistic regression model was employed to analyze factors associated with treatment effectiveness. The predictive value of these factors was assessed using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Within 24 hours post-thrombolysis, primary symptoms and clinical signs significantly improved. Specifically, respiratory rate (RR), heart rate (HR), and partial pressure of carbon dioxide (PaCO₂) decreased significantly, whereas oxygen saturation (SaO₂) and partial pressure of oxygen (PaO₂) increased significantly. Additionally, there was a significant improvement in mean pulmonary artery pressure (MPAP) and right ventricular end-diastolic diameter (RVEDD). Among the patients, 27 demonstrated marked improvement, 81 showed improvement, and these were categorized as the effective group (n=108). The remaining 40 patients showed no improvement and were classified into the ineffective group (n=40). Binary Logistic regression analysis identified PaCO₂ <35 mmHg, D-dimer (D-D) ≥11 mg/L, interleukin-6 (IL-6) ≥24 pg/mL, and C-reactive protein (CRP) ≥16 mg/L as independent risk factors for ineffective thrombolysis in patients with PE and PH (all <i>P</i><0.05). The areas under the curve (AUCs) for PaCO₂, D-D, IL-6, and CRP in predicting thrombolysis efficacy were 0.684, 0.655, 0.634, and 0.629, respectively.</p><p><strong>Conclusion: </strong>Thrombolytic therapy effectively improves clinical symptoms, physical signs, hemodynamic parameters, and cardiac function in patients with PE complicated by PH. Furthermore, in clinical practice, early monitoring of inflammatory markers such as PaCO₂, D-D, IL-6, and CRP is crucial for timely adjustment and optimization of individualized therapeutic strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2654-2664"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced clinical outcome and safety of Danhong injection combined with aspirin and clopidogrel for acute ischemic stroke: a retrospective study.","authors":"Minfeng Lu, Shenfeng Zhang, Longqin Zhang","doi":"10.62347/PEJW5162","DOIUrl":"10.62347/PEJW5162","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of Danhong injection combined with dual antiplatelet therapy (DAPT) in patients with acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 110 AIS patients (aged 40-80 years, National Institutes of Health Stroke Scale 3-15) admitted between October 2021 and October 2023. Patients were divided into two groups: the intervention group (n=55) received Danhong injection (40 mL/day for 14 days) plus DAPT (aspirin 100 mg + clopidogrel 75 mg), while the control group (n=55) received DAPT alone. Primary outcomes included neurological function, infarct volume, and inflammatory/hemorheological markers. Safety was also assessed.</p><p><strong>Results: </strong>The intervention group showed greater neurological improvement, with NIHSS scores decreasing from 8.2 to 3.2 compared to 8.5 to 5.1 in the control group (P<0.001). Functional independence rate was higher in the intervention group (81.8% vs. 54.5%, P=0.002). Infarct volume reduction was more pronounced in the intervention group (5.0 cm³ vs. 6.5 cm³ at 1 month, P=0.003). Inflammatory markers (C-reactive protein, procalcitonin and neutrophil count) and hemorheological measurements (plasma viscosity, whole-blood viscosity) improved significantly (all P<0.05). No severe adverse events were reported.</p><p><strong>Conclusion: </strong>Danhong injection combined with DAPT significantly enhanced neurological recovery, reduced infarct volume, and modulated systemic inflammation in AIS patients, with a favorable safety profile.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3119-3130"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silver needle thermal conduction therapy relieves pain in rats with myofascial pain syndrome.","authors":"Yun Xu, Yunting Chen, Yongfu Feng, Qian Zhang, Tao Zhou, Chunxin Wo, Minmin Zhang","doi":"10.62347/QQBB3856","DOIUrl":"10.62347/QQBB3856","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of silver needle thermal conduction therapy on spinal neurotransmitter activation and inflammation reduction in the myofascial trigger point musculature of a rat model with myofascial pain syndrome (MPS).</p><p><strong>Methods: </strong>The MPS rat model was induced by a combination of impact and exercise fatigue. MPS rats were then subjected to silver needle thermal conduction therapy for 14 days. Thermal and mechanical pain thresholds were assessed using the thermal hyperalgesia and mechanical hyperalgesia tests. Transverse and longitudinal sections of the right medial thigh muscle were prepared for histological analysis using HE staining. Western blot and immunohistochemistry were used to measure the expression of calcitonin gene-related peptide (CGRP), substance P (SP), and 5-hydroxytryptamine (5-HT) in the L4-6 segment of the spinal cord. Additionally, the levels of inflammatory cytokines, including interleukin 1-β (IL-1β) and tumor necrosis factor α (TNF-α), in the right medial femoral muscle were assessed via ELISA.</p><p><strong>Results: </strong>MPS rats exhibited a decreased thermal and mechanical pain threshold compared to control rats. Muscle fiber atrophy and deformation were observed in the MPS rats. Levels of IL-1β and TNF-α were elevated in the right medial femoral muscle, while CGRP and SP expression were increased, and 5-HT expression was decreased in the spinal cord. Silver needle thermal conduction therapy effectively reversed these pathological changes in the MPS rats.</p><p><strong>Conclusions: </strong>Silver needle thermal conduction therapy alleviated MPS in rats by modulating spinal neurotransmitter expression and reducing muscle inflammation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2604-2613"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of surgical timing on the outcomes of traumatic cervical spinal cord injury.","authors":"Chunjian Song, Wei Pan","doi":"10.62347/WHOO7252","DOIUrl":"10.62347/WHOO7252","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between surgical timing and treatment efficacy in patients with traumatic cervical spinal cord injury.</p><p><strong>Methods: </strong>A total of 78 patients with traumatic cervical spinal cord injury were enrolled in Nantong Haimen People's Hospital from January 2019 to June 2022. Of these, 40 patients who received anterior decompression and fixation surgery with bone graft and steel plate within 2-7 days post-injury were assigned to the control group, while 38 patients who received the treatment within 24 h after injury were assigned to the study group. The recovery outcomes, visual analog score (VAS), anxiety score (Self-Rating Anxiety Scale, SAS), depression score (Self-Rating Depression Scale, SAS), and adverse events were compared between the two groups.</p><p><strong>Results: </strong>The study group demonstrated a significantly higher recovery rate compared to the control group (P < 0.05). Additionally, the VAS, SAS, and SDS scores were markedly lower in the study group than those in the control group (all P < 0.05), indicating reduced pain and psychological distress. The incidence of adverse events was also significantly lower in the study group compared to the control group (P < 0.05), underscoring the safety and efficacy of early surgical intervention.</p><p><strong>Conclusions: </strong>Early surgical intervention not only alleviates physical pain but also effectively reduces psychological stress, thereby promoting overall recovery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"2809-2816"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenofovir disoproxil fumarate: safe and effective option for managing high-viral-load chronic hepatitis B.","authors":"Wenyuan Song, Jianzhi Bao","doi":"10.62347/OCYR8437","DOIUrl":"10.62347/OCYR8437","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study evaluated the therapeutic effects of entecavir (ETV) versus tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) patients with high viral loads.</p><p><strong>Methods: </strong>A total of 120 high-viral-load CHB patients were enrolled and assigned to two treatment groups: the ETV group (n = 56) and the TDF group (n = 64). Comparative assessments included hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels, hepatitis B e antigen (HBeAg) seroconversion rates, alanine aminotransferase (ALT) normalization, clinical efficacy, safety, biological and virological responses, biochemical indicators, and treatment satisfaction.</p><p><strong>Results: </strong>The TDF group showed significantly higher HBV-DNA and HBeAg seroconversion rates, as well as ALT normalization, compared to the ETV group at both 24 and 48 weeks post-treatment (all P < 0.05). Additionally, the TDF group demonstrated better clinical efficacy (P < 0.05). While demonstrating no significant difference in the incidence of adverse reactions compared to the ETV group (P > 0.05). Significantly higher biological and virological response rates, as well as treatment satisfaction, were also observed in the TDF group (all P < 0.05). Furthermore, the TDF group exhibited superior efficacy for reducing abnormal biochemical markers (P < 0.05).</p><p><strong>Conclusions: </strong>These findings suggest that TDF is more effective than ETV for treating high-viral-load CHB patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 4","pages":"3228-3234"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}