American journal of translational research最新文献

{"title":"Electroacupuncture attenuated cerebral ischemia injury correlated with increased glucose consumption and elevated hippocampal GLUT1/3 expression.","authors":"Ri Xu, Xu Ma, Minya Zhou, Weiwei Li, Mengyuan Dai, Ruhui Lin, Kunqiang Yu, Lixiu Wu","doi":"10.62347/JESQ9191","DOIUrl":"10.62347/JESQ9191","url":null,"abstract":"<p><strong>Objectives: </strong>Cerebral ischemic stroke (IS) is a prevalent cerebrovascular accident that can lead to severe consequences. Electroacupuncture (EA) has demonstrated efficacy in alleviating cerebral ischemia/reperfusion (I/R) injury; however, the underlying molecular mechanisms remain poorly understood. It has been reported that the upregulation of glucose transporter gene expressions restores the ability of cerebral cells to consume energy during I/R. However, whether the use of EA affects glucose metabolism remains elusive. This study tries to elucidate the role of EA in regulating glucose metabolism during cerebral I/R process.</p><p><strong>Methods: </strong>Rats with middle cerebral artery occlusion (MCAO) were employed as cerebral I/R injury models, and EA were performed at Baihui and Shenting acupoints in the modeled rats as treatment strategies. Additionally, Magnetic Resonance Imaging (MRI) was employed to measure cerebral infarction volume, Positron Emission Tomography/Computed Tomography (PET/CT) to evaluate glucose uptake in the hippocampus, neurological deficit scoring along with Morris Water Maze (MWM) testing was used to assess neurological deficits, and Western blot and Enzyme-linked Immunosorbent Assay (ELISA) tests determined the expression levels of glucose transporters genes GLUT1 and GLUT3.</p><p><strong>Results: </strong>Neurological deficit scoring and MWM test results indicated that EA at Baihui and Shenting acupoints significantly alleviated neurological deficits caused by I/R injury. MRI results also showed that the treatment reduced the cerebral infarction volume. Moreover, PET/CT outcome revealed that EA at the two acupoints enhanced glucose uptake and metabolism in the injured cerebral hippocampus. At the molecular level, EA at the two acupoints significantly upregulated the expression of glucose transporter genes GLUT1 and GLUT3, as evidenced by Western blot results.</p><p><strong>Conclusions: </strong>EA at Baihui and Shenting acupoints can ameliorate I/R injury and facilitate glucose uptake and metabolism by promoting the expression of hippocampal glucose transporter genes GLUT1 and GLUT3.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4256-4266"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics of Mycoplasma pneumoniae and viral infections in hospitalized children with recurrent lower respiratory tract infections.","authors":"Mei Cha, Qin Zhang, Mengjun Luo, Yiting Du, Yuanhu Lu, Jinghua Ye, Jinyan Chen, Yinghong Fan, Haibo Yao, Yixiao Peng, Yanyin Liu, Liangyin Deng, Libing Zhang, Yonghong Lin","doi":"10.62347/RBTR5968","DOIUrl":"10.62347/RBTR5968","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the epidemiological characteristics of Mycoplasma pneumoniae and common viral infections in hospitalized children with recurrent lower respiratory tract infections in Chengdu from 2019 to 2023, and to provide scientific evidence to support clinical diagnosis, treatment, and public health prevention.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on pathogen detection results from 10,580 children hospitalized with recurrent lower respiratory tract infections at a hospital in Chengdu between January 2019 and December 2023.</p><p><strong>Results: </strong>Among the 10,580 hospitalized children, the pathogen detection rate was 28.01%, with Mycoplasma pneumoniae showing the highest positivity rate (17.49%). The detection rates of influenza B virus and Mycoplasma pneumoniae were significantly higher in female children compared to males (all P < 0.05). The positivity rates for adenovirus, respiratory syncytial virus, influenza A virus, and human rhinovirus in 2023 were significantly elevated compared to other years (all P < 0.05). In children under 1 year of age, detection rates for influenza A virus, influenza B virus, and Mycoplasma pneumoniae were lower. The co-detection rate of viral infections and Mycoplasma pneumoniae was low (all P < 0.05). A higher detection rate of Mycoplasma pneumoniae was observed in 3-year-olds, along with a higher co-detection rate of two pathogens (all P < 0.05).</p><p><strong>Conclusion: </strong>Mycoplasma pneumoniae is the predominant pathogen in hospitalized children with recurrent lower respiratory tract infections. Gender, age and season significantly influence pathogen positivity rates. Notably, in 2023, the positivity rates of many pathogens increased significantly, potentially related to changes in COVID-19 prevention and control measures.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4341-4350"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conbercept combined with retinal photocoagulation significantly improves visual acuity and quality of life in patients with proliferative diabetic retinopathy.","authors":"Yalan Cheng, Qingjie Wang, Lanlan Chen, Jibin Zhou","doi":"10.62347/IOVP2431","DOIUrl":"10.62347/IOVP2431","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of Conbercept combined with retinal photocoagulation in patients with proliferative diabetic retinopathy (PDR) and its effect on visual acuity and related outcomes.</p><p><strong>Methods: </strong>This retrospective study included 120 PDR patients treated between January 2019 and January 2021. Based on treatment modality, patients were assigned to a study group (SG, n=60; Conbercept combined with retinal photocoagulation) or a control group (CG, n=60; retinal photocoagulation alone). Surgical data, best-corrected visual acuity (BCVA), central macular thickness (CMT), frequency of Conbercept injections, incidence of postoperative complications, quality of life (QoL) scores, and the need for additional pan-retinal photocoagulation (PRP) were compared between the two groups. Multivariate logistic regression was performed to identify independent risk factors associated with surgical complications.</p><p><strong>Results: </strong>Compared to the CG, the SG demonstrated significantly reduced intraoperative bleeding and greater improvements in BCVA and CMT from 1-48 months postoperatively (<i>P</i><0.05). The SG required fewer additional PRP sessions at 6 months postoperatively (<i>P</i><0.05), and demonstrated significantly lower rates of vitreous hemorrhage and macular edema recurrence (<i>P</i><0.05). QoL scores were significantly higher in the SG at the 48-month follow-up (<i>P</i><0.05). Logistic regression analysis identified age ≥60 years, disease duration ≥15 years, baseline HbA1c ≥8.5%, surgical duration ≥90 minutes, intraoperative bleeding ≥2 mL, and lack of early anti-VEGF therapy as independent risk factors for postoperative complications (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The combination of Conbercept with retinal photocoagulation significantly improved visual outcomes and reduced postoperative complications in PDR patients, particularly beneficial for patients with advanced age, prolonged disease duration, elevated HbA1c, extended surgical duration, or intraoperative bleeding.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4590-4600"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-regulation between adipose tissue innervation and metaflammation: a potential therapeutic target for obesity.","authors":"Weichang Shi, Huiwen Tan, Chenqian Liao, Zhenmei An","doi":"10.62347/AIWS5429","DOIUrl":"10.62347/AIWS5429","url":null,"abstract":"<p><p>Obesity, marked by adipose tissue dysfunction and systemic metaflammation, poses a major global health burden. Emerging evidence underscores a critical interplay between neural regulation and immune-metabolic crosstalk in obesity pathogenesis. This review highlights the dynamic roles of sympathetic and sensory nerves in lipid metabolism, as well as metaflammation involving macrophage polarization, inflammatory cytokine cascades, and mitochondrial dysfunction. In obesity, decreased sympathetic nerve density and impaired adrenergic receptor signaling compromise lipolysis and thermogenesis, while sensory neuropeptides worsen metabolic dysregulation through immune cell interactions. Adipose tissue macrophages adopt pro-inflammatory phenotypes, releasing cytokines that inhibit insulin signaling - forming pathological crown-like structures. Mitochondrial dysfunction, characterized by excessive fission and reduced fusion, disrupts energy homeostasis and increases oxidative stress. Therapeutic approaches targeting neuropeptide signaling, inflammasome activation, and mitochondrial dynamics show promise in restoring metabolic balance. The neuro-immune-metabolic axis thus represents a novel therapeutic frontier for obesity, supporting integrated strategies targeting neural, inflammatory, and mitochondrial pathways.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4087-4100"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for bleeding and thrombotic complications during extracorporeal membrane oxygenation support in adults based on the MIMIC-IV database.","authors":"Zhifeng Chen, Guiyuan Su, Guohui Zhao, Yang Dong, Junzhi Xiao, Haiyan Yin","doi":"10.62347/AKFK5120","DOIUrl":"10.62347/AKFK5120","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors for bleeding and thrombotic complications during extracorporeal membrane oxygenation (ECMO) support in adults and to develop a predictive model based on these factors.</p><p><strong>Method: </strong>Data from 323 adult patients treated with ECMO in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were retrospectively analyzed. Demographic information, clinical characteristics, and laboratory test results were collected. Kaplan-Meier (K-M) and Cox regression analyses were used to identify risk factors for bleeding and thrombotic complications and construct a predictive model.</p><p><strong>Results: </strong>Bleeding and thrombotic complications was noted in 84 (26.0%) patients, with a median onset time of 13 days after ECMO. Univariate analysis identified age, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, ECMO indication, ECMO withdrawal, extracorporeal cardiopulmonary resuscitation (ECPR), and coagulation function as potential risk factors (all P < 0.05). Multivariate analysis revealed that ECMO withdrawal and platelet count (PLT) were independent protective factors, while D-dimer was an independent risk factor (P < 0.05). A predictive model was developed based on ECMO withdrawal, D-dimer, and PLT, with areas under the curves (AUCs) of 0.932, 0.931, and 0.941 for predicting bleeding complications at 6, 9, and 12 days after ECMO treatment, respectively.</p><p><strong>Conclusion: </strong>The incidence of ECMO-related bleeding and thrombotic complications is high. ECMO withdrawal, PLT, and D-dimer are independent influencing factors. This predictive model can assist in early identification of high-risk patients and guide clinical decision-making.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4839-4848"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undemineralized dentin matrix particles accelerate blood vessel formation in a critical-sized skull defect through activating the TGF-β/PI3K signaling pathway.","authors":"Wei Zu, Xiangwen Zhou, Qingsong Jiang","doi":"10.62347/OJTK8676","DOIUrl":"10.62347/OJTK8676","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of undemineralized dentin matrix (UDDM) particles on bone tissue regeneration and vascularization in a critical-sized skull defect (CSD) mouse model, and to elucidate the molecular mechanisms underlying UDDM extract-mediated promotion of endothelial cell proliferation, migration, and tube formation.</p><p><strong>Methods: </strong>UDDM particles and extracts were sourced from human third molars. A CSD mouse model was established, and UDDM particles were implanted into the defect site. Bone regeneration and vascularization (blood vessel volume and area) were assessed using micro-computed tomography (Micro-CT). Human umbilical vein endothelial cells (HUVECs) were treated with UDDM extract and a phosphatidylinositol 3-kinase (PI3K) inhibitor (HY-15244). Cell proliferation, migration, and tube formation were assessed. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blot were used to analyze the expression of transforming growth factor-beta (TGF-β)/PI3K signaling pathway-related genes and proteins.</p><p><strong>Results: </strong>UDDM particles significantly enhanced bone formation and increased vascular volume and area in the CSD model. UDDM extract promoted HUVEC proliferation, migration, and tube formation, which were reversed by HY-15244 treatment. HY-15244 also inhibited the mRNA and protein expression of TGF-β/PI3K pathway components, which were partially rescued by UDDM extract.</p><p><strong>Conclusion: </strong>UDDM particles promote bone tissue regeneration and angiogenesis in a CSD mouse model. UDDM extract facilitates proliferation, migration, and tube formation of HUVECs by activating the TGF-β/PI3K signaling pathway. These findings suggest that UDDM particles and extracts hold promise for therapeutic application in bone defect repair and vascularization.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4689-4700"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrauterine adhesion after missed miscarriage evacuation: efficacy of different estrogen doses on incidence and risk factors.","authors":"Bianju Xu, Jie Yang, Xue Bai, Chao Liu","doi":"10.62347/ZKJF6580","DOIUrl":"10.62347/ZKJF6580","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of different doses of estradiol valerate in preventing intrauterine adhesion (IUA) incidence and promoting endometrial recovery after curettage for retained abortion.</p><p><strong>Methods: </strong>A total of 188 patients who underwent Missed Miscarriage (MM) by curettage were retrospectively assigned to three groups based on the preoperative estradiol valerate dosage: Group A (3 mg/day), Group B (5 mg/day), and Group C (no estrogen). Postoperative outcomes, including IUA incidence (assessed by hysteroscopy), endometrial thickness (transvaginal ultrasound), menstrual recovery, and adverse reactions, were compared among groups. Logistic regression and ROC curve analysis were used to identify independent risk factors for IUA.</p><p><strong>Results: </strong>Group B showed the lowest IUA incidence (4.84% vs. 7.14% in Group A and 21.43% in Group C, P < 0.001), greater endometrium thickness at 14 days postoperatively, and shorter menstrual recovery time (P < 0.001). Preoperative endometrial thickness < 4 mm and a history of IUA were identified as independent risk factors (AUC = 0.760). The incidence of adverse reactions did not differ significantly among the groups (P > 0.05).</p><p><strong>Conclusion: </strong>Preoperative administration of 5 mg/day estradiol valerate significantly reduces IUA incidence and enhances endometrial recovery after curettage. A thin endometrium and prior IUA history are key risk factors for postoperative adhesion formation.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4818-4826"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA SNHG5 promotes the invasion and proliferation of oropharyngeal squamous cell carcinoma by regulating the miR-21/PTEN signaling pathway.","authors":"Lili Zhong, Chenxi Liu, Zhanglong Huang, Shiwei Ding, Xiaofei Li, Dan He","doi":"10.62347/YAED9730","DOIUrl":"10.62347/YAED9730","url":null,"abstract":"<p><strong>Objective: </strong>To delineate the functional role of long non-coding RNA (LncRNA) SNHG5 in oropharyngeal squamous cell carcinoma (OPSCC).</p><p><strong>Methods: </strong>The expression of LncRNA SNHG5 in paired tumor/adjacent tissues and cell lines (HN6 vs. HIOEC) were detected, and the relationship between LncRNA SNHG5 expression in cancer tissues and the clinicopathological characteristics and prognosis of patients was analyzed. The functional characterization including proliferation, expression of LncRNA SNHG5, miR-21, PTEN, VEGF, MMP-9, cell invasion, as well as cell apoptosis were detected in siRNA-mediated SNHG5 knockdown in HN6 cells.</p><p><strong>Results: </strong>Tumor tissues exhibited higher SNHG5 expression versus adjacent mucosa (P<0.001). Elevated SNHG5 positively correlated with advanced TNM staging, lymph node metastasis, and poor differentiation (P<0.05). Patients with high SNHG5 showed significantly reduced 5-year overall survival (P=0.035). SNHG5 silencing decreased proliferation and invasion capacity, while increasing apoptosis. Mechanistically, SNHG5 knockdown downregulated oncogenic miR-2, VEGF, and MMP-9, while restoring tumor-suppressive PTEN expression.</p><p><strong>Conclusion: </strong>Our findings suggest SNHG5 is a master oncogenic regulator in OPSCC that mechanistically promotes tumor progression via miR-21/PTEN pathway activation. The strong association between SNHG5 overexpression and adverse clinicopathological features, coupled with its prognostic independence, positions this lncRNA as a promising therapeutic target and molecular stratification biomarker.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4387-4398"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hematologic composite score integrating iron, coagulation, and inflammation markers predicts diabetic retinopathy severity: a retrospective cross-sectional study.","authors":"Ying Ma, Anqi Pei, Qi Zhao","doi":"10.62347/IFII7191","DOIUrl":"10.62347/IFII7191","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to develop and validate a hematological composite score incorporating ferritin, transferrin, fibrinogen, and the neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) to predict diabetic retinopathy (DR) severity.</p><p><strong>Methods: </strong>In this single-center retrospective cross-sectional study, 356 patients with type 2 diabetes were categorized into non-DR (n=142), non-proliferative DR (NPDR, n=112), and proliferative DR (PDR, n=102). The composite score was calculated as: (Ferritin × Fibrinogen × NLR × PLR)/Transferrin. Multivariable logistic regression and receiver operating characteristic (ROC) analyses were conducted to evaluate predictive performance, adjusting for relevant covariates.</p><p><strong>Results: </strong>The composite score showed strong discriminatory ability for identifying PDR (AUC=0.898; 95% CI: 0.85-0.93), significantly outperforming individual markers (e.g., ferritin AUC=0.744, fibrinogen AUC=0.722; P<0.001). Each standard deviation increase in the score was associated with a 2.8-fold higher odds of PDR (adjusted OR=2.83; 95% CI: 2.12-3.78). Subgroup analysis revealed greater predictive accuracy in patients with diabetes duration ≥10 years (AUC=0.92) compared to those with <10 years (AUC=0.82; P for interaction =0.012).</p><p><strong>Conclusions: </strong>This hematologic composite score, integrating iron, coagulation, and inflammation markers, offers a cost-effective and clinically accessible tool for DR severity assessment, particularly in patients with long-standing diabetes. Its implementation may enhance screening precision and inform individualized management strategies.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4433-4444"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of heparin-binding protein with risk of in-hospital heart failure in patients with acute coronary syndrome.","authors":"Xiao Liang, Qingxian Tu, Jie Zhang, Min Xu, Zhenglong Wang","doi":"10.62347/LQLD9274","DOIUrl":"10.62347/LQLD9274","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the relationship between heparin-binding protein (HBP) levels and the risk of involving heart failure occurring during hospitalization in patients with acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>This single-center retrospective study included 274 patients with ACS hospitalized at the Third Affiliated Hospital of Zunyi Medical University between June and December 2023. The primary outcome was the occurrence of in-hospital heart failure (HF). Multivariable logistic regression and restricted cubic spline (RCS) models were used to assess the relationship between HBP and HF. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of HBP for HF events.</p><p><strong>Results: </strong>During hospitalization, 56 patients (20.4%) developed HF. Patients with HF patients had higher HBP levels (<i>p</i> < 0.01). HBP was significantly associated with in-hospital HF risk (Model 3 OR = 4.232, <i>P</i> < 0.001). ROC analysis showed that HBP had a predictive value for HF events (AUC = 0.696, sensitivity = 55.36, specificity = 76.61, <i>P</i> < 0.001). The RCS model indicated a nonlinear dose-response relationship between HBP levels and in-hospital HF (<i>P</i> for nonlinearity = 0.007).</p><p><strong>Conclusion: </strong>HBP levels are associated with an increased risk of in-hospital HF in patients with ACS and serve as a superior predictor compared to traditional parameters and inflammatory markers.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4237-4246"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}