American journal of translational research最新文献

{"title":"Application of engineered exosomes in tumor therapy.","authors":"Chunhui Ma, Wei Tang, Jiaye Wang, Shiyu Yang, Jin Hou, Meng Guo, Lu Hao","doi":"10.62347/KIXF4662","DOIUrl":"https://doi.org/10.62347/KIXF4662","url":null,"abstract":"<p><p>Malignant tumors pose a significant threat to human health, and conventional cancer therapies are limited by inadequate targeting, leading to severe side effects. Exosomes, as extracellular vesicles mediating intercellular communication, exhibit advantages such as low immunogenicity, high biocompatibility, and low toxicity. After modification, engineered exosomes can be employed as targeted delivery vehicles in tumor therapy. This review summarizes the cellular origin, production methods, engineering strategies, and drug-loading routes of engineered exosomes, discusses their applications in cancer treatment, and delves into the challenges and issues in translating engineered exosomes to clinical practice, aiming to provide insights for exosome engineering research.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"736-747"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDC42: unlocking a novel therapeutic target for primary sclerosing cholangitis through Mendelian randomization.","authors":"Jie Zhou, Yixin Xu, Haitao Wang, Chao Chen, Kun Wang","doi":"10.62347/BTYN8678","DOIUrl":"https://doi.org/10.62347/BTYN8678","url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to identify new drug targets for Primary Sclerosing Cholangitis (PSC), a condition currently lacking effective treatment, to improve survival without transplantation.</p><p><strong>Methods: </strong>We obtained summary statistics for 2,888 druggable genes and PSC from the eQTLGen Consortium and the FinnGen consortium, respectively. Through two-sample Mendelian randomization using the Inverse Variance Weighted (IVW) method, we identified genes associated with PSC at a False Discovery Rate (FDR) < 0.05. Further validation came from colocalization and Summary-data-based Mendelian Randomization (SMR) analyses, confirming the reliability of our results.</p><p><strong>Results: </strong>Five druggable genes were causally associated with PSC at FDR < 0.05. Subsequent colocalization and SMR analyses further confirmed that higher levels of CDC42 in plasma were associated with an increased risk of PSC (IVW method: Odds Ratio 1.319, 95% Confidence Interval 1.182-1.471, <i>P</i> = 6.85E-07, FDR = 0.002).</p><p><strong>Conclusions: </strong>Our research pioneered the identification of CDC42 as a target for slowing PSC progression. Our research not only uncovers a possible drug target but also provides direction for the development of therapeutics for PSC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1076-1086"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the neutrophil to lymphocyte ratio for cardiovascular diseases: research progress.","authors":"Xinyue Zhang, Dongyang Li, Yanwei Du","doi":"10.62347/KVCV7377","DOIUrl":"https://doi.org/10.62347/KVCV7377","url":null,"abstract":"<p><p>The neutrophil to lymphocyte ratio (NLR) is a simple, reliable, and easily accessible composite index that has garnered increasing attention in cardiovascular research. NLR is closely associated with the onset, progression, and prognosis of various cardiovascular diseases. This article reviews the etiological and prognostic roles of NLR in cardiovascular conditions such as coronary atherosclerotic heart disease, hypertension, arrhythmia, heart failure, and valvular heart disease. Studies have shown that NLR is involved in the pathophysiologic processes of these diseases and holds significant predictive value for their prognosis. Additionally, compared to other inflammatory markers, NLR offers advantages such as low cost, repeatability, and the ability to be measured at the community-level primary healthcare settings, thus providing new insight for prognostic prediction in conditions like coronary artery disease, arrhythmia, hypertension, heart failure, and valvular heart disease.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1170-1177"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinoline conjugates for enhanced antimalarial activity: a review on synthesis by molecular hybridization and structure-activity relationship (SAR) investigation.","authors":"Shashidhar Bharadwaj Srinivasa, Sakshi Naveen Ullal, Bhuvanesh Sukhlal Kalal","doi":"10.62347/TTHX6526","DOIUrl":"https://doi.org/10.62347/TTHX6526","url":null,"abstract":"<p><p>Malaria, caused by the various <i>Plasmodium falciparum</i> strains, has been one of the deadliest diseases spread across the world. Over the years, several researchers have been employed to analyse molecular hybridization techniques for the synthesis of combination drugs to overcome the resistance gained by the parasite against the existing drugs. Hence, some of the significant contributions since 2019 till date have been summarised in the present review. Based on structure, the hybrids have been classified into bi-pharmacophores - having two pharmacologically active groups, tri-pharmacophores - having three pharmacologically active groups, metal-based and other miscellaneous hybrids. A thorough study of existing molecules could also reveal new leads for the development of anti-malarial agents with efficacy better than the preceding ones.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1335-1375"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized operating room nursing care is effective in preventing the occurrence of surgical wound infections.","authors":"Xuelei Pei, Yingming Song","doi":"10.62347/MLLI7876","DOIUrl":"https://doi.org/10.62347/MLLI7876","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical effectiveness of standardized operating room nursing care in preventing wound infections from orthopedic surgery.</p><p><strong>Methods: </strong>A total of 128 patients requiring orthopedic surgery were selected and divided into a control group and an observation group in accordance with the nursing care they received during surgery, with 64 patients in each group. Patients in the control group received conventional operating room nursing care, while those in the observation group received standardized operating room nursing care. The post-operative outcomes of patients in both groups, including wound healing rates, nursing management clinical indicators, incidence rates of wound infections and infection-associated complications, patients' mastery of infection-associated knowledge, patients' quality of life, and their satisfaction degree towards nursing care, were compared between groups.</p><p><strong>Results: </strong>Patients in the observation group showed a significantly higher wound healing rate compared to those in the control group (P < 0.01). The nursing management clinical indicators, such as the time to first eating and first ambulation after surgery, and the duration of hospital stay were all significantly shorter in the observation group than those in the control group (all P < 0.01). The incidence of postoperative wound infections in the observation group was 0.00%, which was significantly lower than the 21.88% observed in the control group (P < 0.001). After nursing care, the quality of life scores of patients in the observation group were significantly better than those in the control group (P < 0.01). The study also found that the overall satisfaction of patients in the observation group was 98.44%, significantly higher than 84.38% observed in the control group (χ² = 27.349, P < 0.001).</p><p><strong>Conclusion: </strong>Standardized operating room nursing care is an effective way to prevent the occurrence of surgical wound infections. This kind of care helps patients establish healthy lifestyles and assists in improving relevant clinical indicators, which is worthy of being promoted in clinical settings.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1125-1134"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of low- and high-frequency sacral neuromodulation on urinary symptoms: high-frequency improves Qmax, low-frequency enhances bladder capacity.","authors":"Yuansong Xiao, Hui Zhang, Haoyu Yuan, Xiaoyu Lin, Chenglin Yang, Jixian Gao","doi":"10.62347/IGEX6196","DOIUrl":"https://doi.org/10.62347/IGEX6196","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy, safety, and patient satisfaction between low- and high-frequency sacral neuromodulation (SNM) in patients undergoing SNM.</p><p><strong>Methods: </strong>This retrospective study included 263 patients treated between January 2016 and December 2022 at PLA General Hospital of Southern Theater Command. Patients received either low-frequency (≤ 16 Hz) or high-frequency (> 16 Hz) SNM. Urodynamic outcomes, quality of life, adverse events, and patient satisfaction were assessed pre- and post-treatment.</p><p><strong>Results: </strong>Of the cohort, 128 patients received low-frequency and 135 received high-frequency stimulation. Post-treatment, the high-frequency group showed a significant improvement in maximum urinary flow rate (Qmax) and detrusor contractility compared to the low-frequency group. In contrast, the low-frequency group exhibited greater increases in maximum bladder capacity. Both groups demonstrated significant reductions in urination difficulty and waiting times, with the high-frequency group achieving more pronounced improvements. Quality of life scores and adverse event rates were similar across both groups. High patient satisfaction was noted in both groups, with no significant difference in overall satisfaction rates (P = 0.404). Correlation analysis indicated significant relationships between stimulation frequency and various urodynamic parameters, with higher frequencies generally associated with better urodynamic outcomes.</p><p><strong>Conclusion: </strong>Both low- and high-frequency SNM improve urinary symptoms and quality of life, with high-frequency showing better urodynamic outcomes in Qmax and detrusor contractility, while low-frequency enhances bladder capacity. Both treatments are safe and highly satisfactory to patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1114-1124"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xianling Gubao capsules improve oral health, alveolar bone defects, and bone density in patients with periodontitis.","authors":"Wen Zhou, Yanli Zhu, Shibo Zhang","doi":"10.62347/GCDD8292","DOIUrl":"https://doi.org/10.62347/GCDD8292","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of Xianling Gubao Capsules (XGC) on alveolar bone and inflammatory mediators in the gingival crevicular fluid in patients with periodontitis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 90 periodontitis patients who received medication treatment at Daqing Longnan Hospital from September 2022 to June 2023. Patients were categorized into three groups: a control group (n=30, receiving basic periodontal treatment), a Caltrate group (n=30, receiving basic treatment plus Caltrate), and an XGC group (n=30, receiving basic treatment plus Xianling Gubao Capsules). Changes in alveolar bone defect height, alveolar bone density, plaque index (PI), probing depth (PD), gingival index (GI), gingival crevicular fluid volume, and inflammatory mediator levels were compared before and after treatment.</p><p><strong>Results: </strong>After 3 and 6 months of treatment, the XGC group exhibited significantly reduced alveolar bone defect height in incisors, canines, premolars, and molars and significantly increased alveolar bone density compared with the other two groups (all P<0.05). The XGC group also exhibited lower tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels and higher interleukin-17 (IL-17) levels than the Caltrate and control groups (all P<0.05). Additionally, PI, PD, GI, and gingival crevicular fluid volume were significantly lower in the XGC group at both time points (all P<0.05). The incidence of adverse reactions did not differ significantly among the three groups (P>0.05).</p><p><strong>Conclusion: </strong>Xianling Gubao Capsules, when combined with conventional periodontal treatment, may enhance alveolar bone density, reduce alveolar bone defects, alleviate periodontal inflammation, and modulate inflammatory mediator levels in the gingival crevicular fluid. These findings suggest clinical benefits for periodontitis management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1376-1387"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining orofacial stimulation with gentle touch therapy improves breastfeeding tolerance and weight gain in preterm infants.","authors":"Fan Yao, Qiong Mei, Ling Guo, Min Liang","doi":"10.62347/NDYX6291","DOIUrl":"https://doi.org/10.62347/NDYX6291","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of orofacial stimulation combined with gentle touch therapy on breastfeeding intolerance and weight gain in preterm infants.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at Wuhan Children's Hospital, involving 236 preterm infants diagnosed with breastfeeding intolerance. Of these, 130 infants received a combination of gentle touch and orofacial stimulation (combination group), while 106 infants received only gentle touch therapy (only-touch group). The intervention lasted for three months. Outcomes were assessed using clinical indicators of breastfeeding intolerance, the Neonatal Oral Motor Assessment Scale (NOMAS), growth measurements (weight, height, and head circumference), and levels of calcium, albumin, prealbumin, and bilirubin. Statistical analyses were performed using SPSS 23.0.</p><p><strong>Results: </strong>The combination group demonstrated a higher rate of improvement in breastfeeding intolerance compared to the only-touch group (significantly improved cases: 60 vs. 30; ineffective cases: 7 vs. 44; χ² = 28.267, P < 0.05). Oral motor function improved significantly more in the combination group (P < 0.05). After 1 and 3 months, the combination group showed greater increases in weight, height, and head circumference (Height: P = 0.025 at 1 month; Head circumference: P = 0.034 at 3 months). The duration of residual milk was significantly reduced in the combination group by the end of the observation period (P < 0.001). Nutrient analysis revealed higher levels of calcium, albumin, and prealbumin post-nursing (P < 0.05), and bilirubin levels decreased significantly after one month (t = 5.987, P < 0.05).</p><p><strong>Conclusion: </strong>Combining orofacial stimulation with gentle touch therapy improves breastfeeding tolerance, oral motor function, growth, and nutritional status in preterm infants more effectively than touch therapy alone.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"961-973"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and risk factors of pulmonary fungal infection in patients with pulmonary tuberculosis.","authors":"Yan Wu, Yanna Yang, Yao Lu","doi":"10.62347/CBWV2685","DOIUrl":"https://doi.org/10.62347/CBWV2685","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the characteristics of and the risk factors for pulmonary fungal infection in patients with pulmonary tuberculosis (PT).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 218 PT patients treated at Beijing Luhe Hospital Affiliated with Capital Medical University from May 2022 to May 2024. Based on the presence or absence of fungal infection, these 218 patients were assigned to an infection group (n=87) or a non-infection group (n=131). Clinical baseline data, pulmonary fungal infection status ten days after admission, clinical symptoms on the first day of admission, and serum protein and hemoglobin levels were compared between the two groups. Logistic regression analysis was conducted to identify independent risk factors for pulmonary fungal infection in PT patients. A receiver operating characteristic (ROC) curve was generated to evaluate the predictive performance of these independent risk factors.</p><p><strong>Results: </strong>Among the 218 PT patients included, 87 (39.91%) had fungal infections. A total of 210 fungal strains were isolated and cultured from the infection group, with Candida albicans accounting for the highest proportion (42.65%), followed by candida tropicalis (20.59%) and Candida glabrata (17.65%). The infection group exhibited significantly higher rates of cough, fever, anemia, and pulmonary rales compared to the non-infection group (all P<0.05). The infection group showed significantly lower levels of serum protein and hemoglobin than the non-infection group (P<0.0001). Multivariate analysis identified history of smoking, disease course, duration of corticosteroid use, invasive procedure, serum protein level, and hemoglobin level as independent factors for fungal infection in PT patients. ROC curve analysis indicated that serum protein levels had the highest accuracy and area under the curve (AUC) value, while smoking history and hemoglobin levels performed less well in the model.</p><p><strong>Conclusion: </strong>This study found a high rate of pulmonary fungal infections among PT patients, with <i>Candida albicans</i> being the most prevalent, followed by <i>candida tropicalis</i> and <i>Candida glabrata</i>. A history of smoking, a prolonged disease course, invasive procedures, extended corticosteroid use, and low serum protein and hemoglobin levels are independent factors for fungal infection in PT patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"951-960"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of interference electrotherapy combined with rotary traction manipulation on cervical function and recurrence in patients with cervical spondylotic radiculopathy.","authors":"Pengcheng Zhang, Wu Li, Yunfeng Shang, Jiangshan Li, Cui Zhou, Jianbo Lei","doi":"10.62347/BMNP8126","DOIUrl":"https://doi.org/10.62347/BMNP8126","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of combining interference electrotherapy with rotary traction manipulation in treating cervical spondylotic radiculopathy (CSR), and to assess its impact on cervical function and prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data from 214 CSR patients who were treated at Yueyang Central Hospital, Hunan University of Chinese Medicine, from April 2021 to October 2023. The observation group (n=110) received combined therapy using interference electrotherapy and rotary traction manipulation, while the control group (n=104) received rotary traction manipulation alone. Before treatment, and at 2 and 4 weeks post-treatment, cervical function was assessed using the Neck Disability Index (NDI), and pain intensity was measured using components of the Simplified McGill Pain Questionnaire (SF-MPQ), including Visual Analog Scale (VAS), Present Pain Intensity (PPI), and Pain Rating Index (PRI). Clinical efficacy was evaluated using the modified Macnab criteria, and treatment safety was assessed. Both groups were followed up for one year to record recurrence rates. Logistic regression was used to identify risk factors for recurrence.</p><p><strong>Results: </strong>Baseline characteristics were similar between groups (P>0.05). After 2 and 4 weeks, the observation group showed significantly greater improvements in NDI, VAS, PRI, and PPI scores compared to the control group (P<0.001). The total effective rate was higher in the observation group (92.7%) than in the control group (80.8%) (P=0.017). However, the recurrence rate was significantly higher in the observation group (7.3%) compared to the control group (20.2%) (P=0.006). Logistic regression identified treatment regimen, patient age, and pillow height as independent risk factors for recurrence (P<0.05). A recurrence risk scoring model based on these factors achieved an AUC of 0.897 (95% CI: 0.844-0.951).</p><p><strong>Conclusion: </strong>Combining interference electrotherapy with rotary traction manipulation significantly improves cervical function and alleviates pain in CSR patients, yielding higher overall efficacy. However, this combination is associated with an increased risk of recurrence, influenced by treatment method, patient age, and pillow height.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1005-1017"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}