American journal of translational research最新文献

{"title":"Circ_0007429 promotes hepatocellular carcinoma resistance to sorafenib through the miR-377-3p/THBS1 axis.","authors":"Panpan Tan, Yuchen Du, Ruijuan He, Zhan Shi, Shanshan Xie, Yuanyuan Zhao, Baitao Wang, Baoqin Ping, Zhe Fang, Yu Zhang, Ao Liu, Yanwei Sun, Yun Song","doi":"10.62347/GUJU9257","DOIUrl":"10.62347/GUJU9257","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate the function of circ_0007429 in hepatocellular carcinoma (HCC) chemoresistance, with a focus on its regulatory mechanisms via the miR-377-3p/THBS1 (Thrombospondin 1) axis.</p><p><strong>Methods: </strong>The expression levels of circ_0007429, miR-377-3p, and THBS1 mRNA were quantified using quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). Cell viability was assessed with the CCK-8 assay, and THBS1 protein expression was evaluated by western blotting. The interactions between miR-377-3p and circ_0007429 or THBS1 were confirmed using luciferase reporter assays.</p><p><strong>Results: </strong>Circ_0007429 expression was substantially upregulated in sorafenib-resistant (SR) HCC cells. Knockdown of circ_0007429 accelerated sorafenib sensitivity by suppressing cell survival. Mechanistically, circ_0007429 acted as a molecular sponge for miR-377-3p, whose activity was increased upon circ_0007429 silencing. THBS1 was recognized as a downstream target of miR-377-3p, and its expression was suppressed by miR-377-3p. Circ_0007429 is a ceRNA for miR-377-3p, thus controlling THBS1 translation and contributing to sorafenib resistance.</p><p><strong>Conclusion: </strong>Circ_0007429 silencing enhances sorafenib sensitivity in HCC through the miR-377-3p/THBS1 axis. circ_0007429 may be a biomarker and therapeutic target for overcoming chemoresistance in HCC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4148-4158"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of pediatric pneumonia: a retrospective study.","authors":"Meimei Wang, Junping Pan","doi":"10.62347/NMGN1230","DOIUrl":"10.62347/NMGN1230","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the clinical characteristics of pneumonia in infants and children and to provide robust clinical evidence for its prevention and treatment.</p><p><strong>Methods: </strong>This retrospective study analyzed the clinical data from pediatric patients diagnosed with pneumonia who were admitted to The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei) between March 2023 and September 2023. Collected variables included sex, age, pneumonia vaccination rates, clinical diagnosis, severity of pneumonia, presence of fever, levels of C-reactive protein (CRP) and procalcitonin (PCT), incidence of anemia, use of ventilator-assisted breathing, length of hospitalization, and results of pathogen detection.</p><p><strong>Results: </strong>The incidence of rhinovirus, bocavirus, respiratory syncytial virus, and influenza A virus was significantly higher in children with severe pneumonia, who also showed a greater prevalence of mixed infections. These patients exhibited higher rates of fever, elevated CRP and PCT levels, more frequent anemia, increased reliance on ventilatory support, and prolonged hospital stays. Compared with patients with non-mixed infections, those with mixed infections showed lower pneumonia vaccination rates, significantly higher CRP and PCT levels, increased need for ventilatory support, and longer durations of hospitalization.</p><p><strong>Conclusions: </strong>In pediatric patients with pneumonia, severe cases were associated with a higher incidence of multiple viral infections and more frequent mixed infections, which correlated with more pronounced clinical symptoms. Patients with mixed infections also demonstrated lower vaccination coverage and greater disease severity. These findings underscore the need for enhanced surveillance, targeted prevention, and optimized treatment strategies, particularly for severe and mixed infection cases in the pediatric population.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4642-4650"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant human bone morphogenetic protein-2 (rhBMP-2) induced macrophage biphasic polarization regulated by dexamethasone in vivo.","authors":"Aikebaier Aixirefu, Yang Liu, Jing Wang","doi":"10.62347/UGHK3747","DOIUrl":"10.62347/UGHK3747","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate macrophage polarization dynamics in vivo after implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2) incorporated biomaterials, with a focus on dose-dependent effects and polarization modulation strategies.</p><p><strong>Methods: </strong>A murine dorsal subcutaneous implantation model was utilized to analyze macrophage responses to varying concentrations of rhBMP-2-loaded biomaterials with or without dexamethasone (Dex). Polarization patterns were assessed through phenotypic characterization and cytokine expression profiling.</p><p><strong>Results: </strong>Elevated rhBMP-2 concentrations amplified macrophage polarization activities, and concurrent activation of M1 and M2 polarization was observed accompanied by enhanced expression of both pro-inflammatory (M1-associated) and anti-inflammatory (M2-associated) cytokines. Dexamethasone co-administration effectively attenuated pro-inflammatory polarization patterns induced by high-dose rhBMP-2 implants while preserving regenerative cytokine expression.</p><p><strong>Conclusions: </strong>Optimized rhBMP-2 dosage facilitates a balanced macrophage polarization state, creating a pro-regenerative microenvironment through coordinated inflammatory resolution and tissue remodeling signals. For clinical applications requiring high rhBMP-2 doses, concurrent short-term anti-inflammatory therapy (e.g., dexamethasone) is recommended to mitigate excessive M1 polarization without compromising osteoinductive capacity.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4159-4174"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of PKCi-mediated pluripotency and gene expression by polycomb complex 1 in mouse embryonic stem cells.","authors":"Fangfang Wu, Zhihui Liu, Xiaohu Wu, Jinshan Li, Xiao Chen, Lan Yang, Fuliang Du","doi":"10.62347/JVZI6615","DOIUrl":"10.62347/JVZI6615","url":null,"abstract":"<p><strong>Objectives: </strong>Epigenetic modification of Polycomb repressive complex 1 (PRC1) plays an important role in regulating the pluripotency and self-renewal of embryonic stem cells (ES). Inhibition of protein kinase C (PKCi) can capture and maintain the pluripotency of mouse ES (mES). Here, we characterized the dynamic expression pattern of PRC1 and its mechanism of action in PKCi-derived mES (PKCi-mES).</p><p><strong>Methods: </strong>The expression of PRC1 components in PKCi-mES, 2iL-derived mES (2iL-mES), and mouse embryonic fibroblasts (MEF) was comparatively analyzed using Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot to identify differentially expressed subunits. Subsequent knockdown of these differential components was performed to examine their effects on cellular differentiation status, along with the expression of pluripotency genes and differentiation genes.</p><p><strong>Results: </strong>We found that PKCi-mES showed high expression of the PRC1 functional catalytic subunit RING1B, canonical PRC1-specific component CBX7, and non-canonical PRC1 specific component RYBP at both gene and protein levels in comparison with control. Knocking down <i>Ring1b</i> and <i>Cbx7</i> accelerated the differentiation of PKCi-mES and reduced the expression of core pluripotency genes and naïve marker genes. Genes associated with mesoderm, ectoderm, and endoderm differentiation were broadly upregulated after <i>Ring1b</i> knockdown, while <i>Cbx7</i> knockdown upregulated the expression of <i>Cbx8</i> and some ectoderm genes but downregulated the expression of some endoderm and mesoderm genes.</p><p><strong>Conclusions: </strong>These results indicate that PKCi activates both the canonical and non-canonical PRC1 pathways, finely regulates the expression of mES pluripotent and developmental genes, and helps maintain mES in a poised state between self-renewal and lineage commitment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4455-4469"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roy Adaptation Model-Based nursing care improves quality of life for elderly burn patients.","authors":"Yudan Wang, Jiang Chang, Guo Fei, Qing Zhou, Dan Sun","doi":"10.62347/UWNY6958","DOIUrl":"10.62347/UWNY6958","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of the Roy Adaptation Model on psychological resilience and nutritional status in elderly burn patients.</p><p><strong>Methods: </strong>Retrospectively, 112 elderly burn patients undergoing routine nursing care based on the Roy Adaptation Model were enrolled as the observation group, and another 112 patients receiving routine nursing care only were selected as the control group. The psychological resilience, level of hope, immunity, emotions, quality of life and sleep of enrolled patients were assessed.</p><p><strong>Results: </strong>In the observation group, patients were observed with markedly improved psychological resilience, notably higher hope and SF-36 scores, significantly lower Self-Rating Anxiety Scale, Self-Rating Depression Scale, Self-Rating Anxiety Scale and Pittsburgh Sleep Quality Index, as well as markedly elevated serum albumin, prealbumin, and hemoglobin, IgM and IgG levels, in contrast to the control group (all P<0.05).</p><p><strong>Conclusion: </strong>Nursing care based on the Roy Adaptation Model can significantly enhance the psychological resilience and hope, improve emotions, pain and sleep quality, strength nutritional absorption and immunity when applied in elderly burn patients, so as to increase their compliance with treatment and quality of life.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4679-4688"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of sacubitril/valsartan sodium on cardiac function and ventricular remodeling in patients with heart failure after PCI for acute myocardial infarction.","authors":"Yawei Jia, Cheng Zhao, Kun Cui, Yunjin Zhang, Guangdong Wang, Qiong Yao, Yuanzheng Zhang","doi":"10.62347/UKIS9778","DOIUrl":"10.62347/UKIS9778","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of sacubitril/valsartan sodium on patients with heart failure following percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI), with a focus on changes in cardiac function and vascular endothelial function.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 108 patients diagnosed with AMI and heart failure after PCI between June 2023 and June 2024. Patients were allocated into two groups based on the treatment regimen. The control group received standard therapy supplemented with valsartan. The study group received sacubitril/valsartan sodium in place of valsartan, in addition to the same standard regimen. Key outcome measures included markers of myocardial injury [cardiac troponin I (cTnI), high-sensitivity C-reactive protein (hs-CRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP)], echocardiographic parameters, indices of cardiac function and ventricular remodeling, six-minute walk distance (6MWD), Kansas City Cardiomyopathy Questionnaire (KCCQ) scores, major adverse cardiovascular events (MACEs), and incidence of adverse reactions.</p><p><strong>Results: </strong>Baseline characteristics were comparable between the two groups. Post-treatment, the study group demonstrated a significantly higher clinical efficacy (P < 0.05). Myocardial injury markers decreased more markedly, and improvements in cardiac function were significantly greater in the study group compared to the control group (P < 0.05). Although the study group exhibited lower incidences of MACEs and adverse reactions, the differences were not statistically significant.</p><p><strong>Conclusion: </strong>Sacubitril/valsartan sodium can significantly improve cardiac function and vascular endothelial function and attenuate ventricular remodeling in patients with heart failure after PCI for AMI. The treatment is well tolerated and demonstrates a favorable safety profile.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4713-4722"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of serum human chorionic gonadotropin and uterine artery Doppler indices in missed abortion.","authors":"Wenjuan Li, Tian Zhang, Panpan Zhuo, Xiangyang Zhao, Yanhua Wang, Yanan Wei","doi":"10.62347/HJTF3431","DOIUrl":"10.62347/HJTF3431","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the combined diagnostic value of serum human chorionic gonadotropin (HCG) levels and uterine artery Doppler indices - including pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) - for identifying missed abortion.</p><p><strong>Methods: </strong>This retrospective cohort study included 160 patients diagnosed with missed abortion and 200 women with normal pregnancies between January 2019 and December 2023. Serum HCG levels were measured using electrochemical immunoassay, and uterine artery Doppler indices were obtained by transvaginal ultrasound. Statistical analyses included independent t-tests, Pearson correlation, receiver operating characteristic (ROC) curve analysis, and Akaike information criterion (AIC)-based model selection to assess diagnostic performance.</p><p><strong>Results: </strong>Compared to normal pregnancies, patients with missed abortion had significantly lower HCG levels and significantly higher PI, RI, and EDV values (all P < 0.001). Serum HCG levels were negatively correlated with PI (r = -0.33), RI (r = -0.24), PDV (r = -0.25), and EDV (r = -0.26). The combined diagnostic model incorporating HCG, PI, RI, PSV, and EDV demonstrated the highest diagnostic accuracy, with an area under the curve (AUC) of 0.941 (95% CI: 0.918-0.964), sensitivity of 86.25%, and specificity of 87.00%.</p><p><strong>Conclusion: </strong>Combining serum HCG levels with uterine artery Doppler indices markedly enhanced the diagnostic accuracy for missed abortion compared to single biomarkers. This multimodal approach offers high sensitivity and specificity, and may be useful in clinical practice.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4225-4236"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of oral anticoagulants in elderly patients with non-valvular atrial fibrillation: a meta-analysis.","authors":"Baocai Fan, Jun Xia","doi":"10.62347/JOJX2439","DOIUrl":"10.62347/JOJX2439","url":null,"abstract":"<p><strong>Background: </strong>Thromboembolism is a common complication in elderly patients with non-Valvular Atrial Fibrillation (NVAF). Noval oral anticoagulants (NOACs) remain the primary treatment strategy. This study focuses on the optimal dosage and safety of new oral anticoagulants introduced in recent years.</p><p><strong>Objective: </strong>To investigate the optimal dose and safety of NOACs in elderly patients with NVAF through meta-analysis.</p><p><strong>Methods: </strong>A systematic literature search was conducted using both Chinese and international academic databases to identify studies on NOAC therapy in elderly patients with NVAF. A total of 22 studies were included. Meta-analysis was performed using RevMan 5.3 software.</p><p><strong>Results: </strong>The risk of systemic embolism (SSE) in patients receiving warfarin was significantly higher compared to those on both standard-dose and low-dose NOACs. Patients who take conventional doses of new anticoagulants orally have a higher risk of developing SSE (P < 0.05). The risk of severe bleeding in patients receiving standard-dose warfarin was higher than those on conventional dose and low-dose NOACs. There was no statistically significant difference in the risk of severe bleeding between patients with conventional and low-dose anticoagulants (P > 0.05). Funnel plots for SSE and major bleeding outcomes were symmetrical and centered around the mean, suggesting low publication bias and reliable results.</p><p><strong>Conclusion: </strong>Low-dose NOACs demonstrate favorable efficacy and safety in elderly NVAF patients, appearing superior to warfarin and conventional dose NOACs. These findings support the preferential use of NOACs over warfarin in this population.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4534-4545"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chebulagic acid ameliorates DSS-induced colitis in mice by improving oxidative stress, inflammation and the gut microbiota.","authors":"Song Zhang, Yali Ren, Min Li, Xin Gao, Xiao Zhang, Weitian Xu, Qiping Lu","doi":"10.62347/QWCQ2468","DOIUrl":"10.62347/QWCQ2468","url":null,"abstract":"<p><strong>Objectives: </strong>Chebulagic acid (CA), isolated from the fruits of <i>Terminalia chebula Retz</i>, has a number of pharmacological activities, but its effect on ulcerative colitis (UC) has not been reported. Here, we explored the protective effect of CA against dextran sulfate sodium (DSS)-induced acute colitis and elucidated the potential mechanisms.</p><p><strong>Methods: </strong>The mouse model of DSS-induced acute colitis was employed to evaluate the effect of CA on UC. The expression of pro-inflammatory cytokines and tight junction proteins were evaluated by quantitative real-time PCR (qRT-PCR). Western blotting was used to explore the potential signal pathway. The gut microbiota was analyzed by 16S rDNA amplicon sequencing.</p><p><strong>Results: </strong>The data showed that CA significantly mitigated colitis severity, as manifested by the suppression of weight loss, shortening of colon, disease activity index (DAI) and histopathological score. CA increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity and reduced malondialdehyde (MDA) content in the colon of colitis mice through inhibiting the mitogen-activated protein kinase (MAPK) pathway and the activating nuclear respiratoty factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway. Meanwhile, myeloperoxidase (MPO) activity and proinflammatory cytokines levels of the CA group were markedly decreased due to suppression of the nuclear factor kappa-B (NF-κB) signaling pathway. Moreover, CA could upregulate the expression of tight junction proteins and reduced apoptosis. Furthermore, CA remodeled the gut microbiota through suppressing the growth of harmful bacteria (<i>Clostridium_sensu_stricto_1</i>, <i>Streptococcus</i> and <i>Escherichia_Shigella</i>) and promoting the growth of beneficial bacteria (<i>Faecalibacterium</i>, <i>Dubosiella</i> and <i>Muribaculaceae</i>).</p><p><strong>Conclusions: </strong>This study revealed that CA treatment could ameliorate DSS-induced acute colitis mainly via reducing oxidative stress and inflammation, maintaining the integrity of the intestinal barrier and modulating diversity and abundance of gut microbiota; thus, CA may become a promising novel drug candidate for initial and maintenance therapy of UC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4101-4118"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridium butyricum CGMCC 0313.1 improves clinical outcomes of metabolic syndrome in schizophrenic patients.","authors":"Libin Song, Zhihua Zhang, Wenyan Zheng, Yiqi Wang, Yingzi Zhang","doi":"10.62347/DNIL9369","DOIUrl":"10.62347/DNIL9369","url":null,"abstract":"<p><strong>Objective: </strong>To primarily analyze the therapeutic effectiveness of <i>Clostridium butyricum</i> CGMCC 0313.1 (CB0313.1) in managing metabolic syndrome (MS) in patients with schizophrenia.</p><p><strong>Methods: </strong>A total of 100 schizophrenic patients with relatively stable conditions admitted were selected. Patients receiving CB0313.1 were assigned to the observation group (n=52), and the others undergoing lifestyle interventions without CB0313.1 were formed the control group (n=48). Additionally, changes in obesity indices, blood sugar (BS) data, lipid profiles, blood pressure (BP), oxidative stress markers, Positive and Negative Syndrome Scale (PANSS) scores, treatment efficacy, and quality of life were evaluated before and after 12 weeks of intervention.</p><p><strong>Results: </strong>After the intervention, the observation group presented significantly greater improvements in oxidative stress reduction, and overall therapeutic efficacy compared to the control group. In addition, the observation group showed more pronounced reductions in obesity indices, BS levels, lipid profiles, BP, and PANSS scores. However, improvements in quality-of-life were comparable between the two groups.</p><p><strong>Conclusion: </strong>CB0313.1 helps enhance the clinical management of MS in schizophrenic patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4399-4408"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}