American journal of translational research最新文献

{"title":"Dyslipidemia and reduced retinal layer thicknesses in mild to moderate non-proliferative diabetic retinopathy.","authors":"Jingjing Wu, Yanrong Chen, Cuiting Huang, Yuqing Wang, Lingli Lin, Zhaode Zhang","doi":"10.62347/EHTP6496","DOIUrl":"10.62347/EHTP6496","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the changes in ganglion cell layer-inner plexiform layer (GCL-IPL) thickness and its association with peripheral blood indices in non-proliferative diabetic retinopathy (NPDR).</p><p><strong>Methods: </strong>In this cross-sectional study, 132 participants were categorized into three groups: 30 healthy volunteers (control group), 50 diabetic patients with non-diabetic retinopathy (NDR group), and 52 patients with NPDR. Optical coherence tomography (OCT) was used to measure the retinal nerve fiber layer (RNFL) and GCL-IPL thicknesses in the macula. The associations between RNFL loss and systemic risk factors for DR, such as diabetes duration, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and hemoglobin A1c (HbA1c) were evaluated.</p><p><strong>Results: </strong>The average, superior, and nasal thicknesses in the NDR and NPDR groups were significantly thinner compared to the control group (P=0.002, 0.020, 0.090, respectively). Similarly, GCL-IPL thicknesses in the 3 mm and 6 mm zones of the NDR and NPDR groups were thinner than those in the control group (P=0.040, 0.022, 0.037, respectively). Temporal thicknesses in the 3 mm range of the NDR and NPDR groups were also thinner than in the control group (P=0.010). Superior RNFL thickness was positively correlated with HbA1c (r=0.200, P=0.044), and negatively correlated with HDL (r=-0.198, P=0.047). The average inferior and nasal GCL-IPL thicknesses were negatively correlated with TC across the 3 mm zone (r=-0.211, P=0.033; r=-0.224, P=0.023; r=-0.227, P=0.022). Additionally, the average thickness of GCL-IPL in the 6-mm range were positively correlated with the duration of diabetes (r=0.196, P=0.048).</p><p><strong>Conclusion: </strong>This study demonstrates that dyslipidemia in diabetic patients correlates with reductions in RNFL and GCL-IPL thicknesses, suggesting a role in the pathogenesis of diabetic retinopathy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes of MMPs during cerebral aneurysm formation in rats and the effect of resveratrol on MMP expression.","authors":"Na Li, Chunyan Fan, Xiaoyi Li, Junhua Su","doi":"10.62347/LKIU6905","DOIUrl":"10.62347/LKIU6905","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the expression of matrix protein metalloenzymes (MMPs) during cerebral aneurysm (CA) formation and assess the effects of resveratrol (RES) on MMP expression and CA prevention.</p><p><strong>Methods: </strong>Male Sprague-Dawley rats were randomly divided into three groups: sham-operated, CA, and RES groups. CA models were constructed by ligating the renal and carotid arteries of SD rats. The RES group received a diet mixed with RES (50 mg/kg), while the CA group was given normal feed; the sham-operated group underwent simulated surgery without ligation and received normal feed. HE staining was used to observe the pathological changes in the cerebral artery aneurysm wall. Immunofluorescence (IF) staining and RT-PCR were used to detect the expression of MMP-2 and MMP-9, as well as oxidative stress markers in the cerebral artery wall tissues of rats at 1-, 2-, and 3-months post-surgery.</p><p><strong>Results: </strong>HE staining reveled that after ligation, the cerebral artery walls of SD rats exhibited irregular thickness, twisted morphology, abnormal nuclear morphology of the cells, and infiltration of inflammatory cells, confirming the successful establishment of CA model. Meanwhile, the infrared spectrogram of the RES purified from Tiger Balm closely matched that of the standard, confirming successful purification. IF staining indicated that MMP-2 and MMP-9 levels dynamically increased over time in the vessel wall of the CA rats. Subsequently, antioxidant assays showed that RES treatment enhanced antioxidant capacity, with increased levels of superoxide dismutase, glutathione peroxidase, and catalase in the vascular wall tissue. Moreover, after 3 months of RES treatment, IF staining showed a marked reduction in MMP-2 and MMP-9 levels in the vessel walls of CA rats. Meanwhile, HE staining also showed improvements in the wall structure, with a more intact wall and an increased vascular endothelial cell density.</p><p><strong>Conclusions: </strong>RES effectively inhibits the expression of MMP-2 and MMP-9, thereby preventing and delaying the development of CA.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy analysis of intermittent pneumatic compression combined with hyperthermia at different temperatures for prevention of deep vein thrombosis after simulated orthopaedic surgery in male rabbits.","authors":"Min Tong, Siping Zhang, Pengcheng Ma, Wenhao Zhang, Limin Mou, Wei Liu, Yifei Huang","doi":"10.62347/OXES9217","DOIUrl":"10.62347/OXES9217","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the optimal combination mode of intermittent pneumatic compression (IPC) when combined with hyperthermia (IPCH) at varying temperatures to prevent lower extremity deep vein thrombosis (DVT) following orthopedic surgery.</p><p><strong>Methods: </strong>Hemodynamic data from a previous experiment on the physiological state and the IPCH (40°C) group were utilized as the control group. Twenty adult male white rabbits, weighing 2.6±0.3 kg, underwent simulated hip surgery and were randomly assigned to the IPCH (42°C) group or the IPCH (45°C) group, with 10 rabbits in each group. IPCH treatment at 42°C and 45°C was administered to the respective groups on the first day post-operation. Hemodynamic data were assessed before and after treatment, followed by finite element hemodynamic analysis using analytical fluid dynamics.</p><p><strong>Results: </strong>In the IPCH (45°C) group, the blood flow velocity distribution vector, total deformation of the femoral vein and venous valve, and equivalent stress of the venous valve were significantly superior compared to the IPCH (40°C) and IPCH (42°C) groups. The increase in equivalent stress of the femoral vein was slightly less than in the IPCH (42°C) group, albeit not statistically significant.</p><p><strong>Conclusion: </strong>IPCH at 45°C demonstrates superior efficacy in enhancing deep venous blood return in the lower extremities compared to IPCH at 40°C and 42°C. Moreover, it maintains the femoral vein and venous valve closer to their physiologic state without elevating the risk of injury or rupture.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of laparoscopic treatment of pediatric inguinal hernia: a meta-analysis.","authors":"Huan Luo, Jianting Xu, Jiahao Chen, Zhenchao Ni","doi":"10.62347/VGGJ1398","DOIUrl":"10.62347/VGGJ1398","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate operative outcomes and postoperative complications of laparoscopic treatment for pediatric inguinal hernia using meta-analysis.</p><p><strong>Methods: </strong>We conducted a comprehensive search of databases including the Chinese Journal Full-text Database, Wanfang, PubMed, Web of Science, ScienceDirect, VIP Chinese Science, and Technology Journal Database, ProQuest, JSTOR, Wiley, and IEEE Xplore. Relevant randomized controlled trials (RCTs) on laparoscopic surgery for pediatric inguinal hernia were collected, and data were analyzed using Review Manager 5.3.</p><p><strong>Results: </strong>A total of 18 RCTs involving 5,750 children (3,357 in the laparoscopic group and 2,393 in the open surgery group) were included. Compared to the open surgery group, the laparoscopic group had significantly shorter operative times for bilateral hernias [(mean difference (MD) = -11.43, P = 0.04)], and lower incidences of metachronous contralateral inguinal hernia (MCIH) (MD = 0.17, <i>P</i> = 0.02) and testicular ascent (MD = 0.19, P = 0.03). However, there were no significant differences in operative time for unilateral hernia (MD = 0.47, P = 0.87), complication rate (MD = 0.87, P = 0.60), postoperative recurrence (MD = 1.46, P = 0.18), incision infection rate (MD = 2.54, P = 0.34), or testicular atrophy rate (MD = 0.36, P = 0.19).</p><p><strong>Conclusion: </strong>Laparoscopic surgery for pediatric inguinal hernia is effective, especially for bilateral cases, reducing operative time and lowering the risk of MCIH and testicular ascent.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dystrobrevin beta is a promising prognostic biomarker and therapeutic target for hepatocellular carcinoma.","authors":"Jin Sun, Yingnan Li, Beibei Bie, Hongwei Tian, Jun Li, Lan Yang, Zhe Zhou, Yanhua Mu, Zongfang Li","doi":"10.62347/FCFO5076","DOIUrl":"10.62347/FCFO5076","url":null,"abstract":"<p><strong>Objectives: </strong>Dystrobrevin beta (DTNB) is a constituent of the dystrophin-associated protein complex (DPC). Our previous RNA sequencing (RNA-seq) study revealed that knockdown of the oncogenic long noncoding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) in hepatocellular carcinoma (HCC) cells could reduce the expression levels of DTNB. However, the association between DTNB and HCC remains uncertain.</p><p><strong>Methods: </strong>The upregulation of DTNB in HCC cell lines and the regulatory effect of HOXD-AS1 on its expression were verified using quantitative real-time PCR (qRT-PCR). The potential clinical significance, biological functions and underlying mechanisms of DTNB in HCC were investigated through bioinformatics analysis. The high expression of DTNB was validated in HCC tissues, and its biological function in HCC was investigated by performing loss-of-function assays <i>in vitro</i>.</p><p><strong>Results: </strong>DTNB was highly expressed in HCC cells and was positively regulated by the lncRNA HOXD-AS1 in several HCC cell lines. The upregulation of DTNB was significantly associated with T stage, histologic grade, tumour status, adjacent hepatic tissue inflammation, alpha-fetoprotein (AFP) level, and unfavorable prognosis, serving as an independent risk indicator associated with overall survival with substantial diagnostic and prognostic implications for HCC. DTNB was also closely linked to immune cell infiltration, immunotherapy, and sensitivity to anti-HCC drugs. Genes co-expressed with DTNB in HCC were identified, and functional enrichment analysis indicated that DTNB may function in HCC by regulating the cell cycle. A potential ceRNA (competing endogenous RNA) regulatory axis of HOXD-AS1/miR-139-3p/DTNB in HCC was predicted and validated. The high expression of DTNB was validated in our HCC cohort and loss-of-function assays revealed that DTNB knockdown can suppress the proliferation, migration, and invasion of HCC cells and trigger cell cycle arrest at the G0/G1 phase.</p><p><strong>Conclusions: </strong>DTNB, a downstream target of the lncRNA HOXD-AS1, has potential utility as a prognostic biomarker and a target for the treatment of HCC.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of coagulation indices in assessinghypertensive disorders in pregnancy and predicting delivery outcomes.","authors":"Wenwen Zhu, Hongqiang Wang, Yu Chen, Lei Qiu, Shuang Cui","doi":"10.62347/FXDK7530","DOIUrl":"10.62347/FXDK7530","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the role of coagulation indices in assessing the severity of hypertensive disorders in pregnancy (HDP) and their predictive value for delivery outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 54 pregnant women with HDP who delivered at Zhoushan Hospital between June 2013 and June 2023. A control group of 42 healthy pregnant women from the same period was also included.</p><p><strong>Results: </strong>In the HDP group, activated partial thromboplastin time (APTT) and prothrombin time (PT) were significantly lower, while D-Dimer (D-D) levels were significantly higher compared to the control group (all P < 0.01). Receiver operating characteristic (ROC) curve analysis showed that the areas under the curve (AUC) for APTT, D-D, PT, and the combined assay were 0.886, 0.813, 0.830, and 0.960, respectively (all P < 0.001). The combined assay demonstrated higher predictive efficacy for HDP than that of any single assay (all P < 0.05). Furthermore, APTT, D-D, and PT showed strong correlations with systolic blood pressure and 24-hour urinary protein levels in HDP patients (all P < 0.001), indicating the corresponding HDP severity. For prediction of adverse birth outcomes (ABO), APTT, D-D, PT, and the combined test all had high predictive value (all P < 0.01). The incidence of ABO, especially neonatal ABO, increased significantly when these coagulation indices (except APTT) were at their optimal cut-off points (P < 0.05).</p><p><strong>Conclusions: </strong>The combined testing of APTT, D-D, and PT provides high predictive efficacy for both HDP and ABO and is closely associated with the severity of HDP.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of frailty status in patients with acute cerebral infarction and their relationship with serum markers.","authors":"Jun Wang, Yanrong Yuan, Yan Zhang, Meidi Wang, Yongxing Yan","doi":"10.62347/CWFR7413","DOIUrl":"10.62347/CWFR7413","url":null,"abstract":"<p><strong>Objective: </strong>Frailty status is closely related to cerebral infarction, but there is a lack of objective biomarkers to determine frailty status in cerebral infarction patients. This study explores frailty status and frailty-related serum markers in patients with acute cerebral infarction and determines their diagnostic value for frailty.</p><p><strong>Methods: </strong>A total of 146 patients with acute cerebral infarction admitted to Hangzhou Third people's Hospital from January 2021 to December 2023 were enrolled prospectively. The Edmonton scale was used to evaluate the patients in the frailty and non-frailty groups. The clinical frailty scale (CFS) was used to divide frailty patients into mild, moderate, and severe frailty groups, comparing clinical data and levels of serum markers among different groups, and analyzing the risk factors for frailty in cerebral infarction.</p><p><strong>Results: </strong>Among the 146 patients, 70 cases (47.9%) were in the frailty group, and 76 cases (52.1%) in the non-frailty group. Compared with patients in the non-frailty group, patients in the frailty group had significantly lower levels of hemoglobin, triglycerides, low-density lipoprotein, and albumin (P<0.05 or 0.01), while levels of C-reactive protein (CRP), D-dimer, and homocysteine (Hcy) were significantly increased (P<0.05 or 0.01). Logistic regression analysis found that the levels of hemoglobin and Hcy were independent risk factors for frailty in acute cerebral infarction patients, with the ROC curve areas of 0.707 and 0.751, respectively. The ROC curve area for predicting frailty by combining hemoglobin and Hcy levels was 0.799.</p><p><strong>Conclusion: </strong>The incidence of frailty in patients with acute cerebral infarction is high, and serum markers of hemoglobin and Hcy have certain value in determining frailty in patients with acute cerebral infarction.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors in acute hypertensive intracerebral hemorrhage: impact of minimally invasive puncture and drainage.","authors":"Dianwei Li, Ming Wei, Shengxiang Wu, Lei Zhang, Zhenzhou Zhang","doi":"10.62347/PQPP5715","DOIUrl":"10.62347/PQPP5715","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the prognostic factors in patients with acute hypertensive intracerebral hemorrhage (HICH) undergoing minimally invasive puncture and drainage, providing scientific evidence to enhance clinical treatment strategies.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 350 patients with acute HICH treated at Gansu Provincial Hospital of Traditional Chinese Medicine and the First People's Hospital of Lanzhou City from March 2017 to January 2024. Patients were divided into two groups based on surgical method: the control group (n = 211) received traditional craniotomy, while the observation group (n = 139) underwent minimally invasive puncture and drainage. Functional scores, inflammatory markers, clinical efficacy, surgical time, first hematoma clearance rate, and hospitalization duration were compared between the groups. Patients were classified into poor prognosis (Glasgow Outcome Scale (GOS) score < 3) and improved prognosis (GOS score ≥ 3) groups. Logistic regression analysis identified independent risk factors for poor prognosis and examined their interaction with patient outcomes.</p><p><strong>Results: </strong>Postoperative functional scores (National Institutes of Health Stroke Scale (NIHSS) score, GOS score, and Barthel Index) in the observation group were significantly better than those in the control group (all P < 0.001). Inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)) were significantly lower post-treatment in the observation group compared to those in the control group (all P < 0.001). Multivariate logistic regression identified age (P = 0.003, OR = 0.573), time from onset to admission (P = 0.026, OR = 0.535), duration of hypertension (P = 0.006, OR = 1.766), and postoperative IL-6 levels (P = 0.048, OR = 1.870) as independent risk factors for poor prognosis. Prognosis was statistically associated with age (P = 0.040, OR = 0.978), time from onset to admission (P = 0.022, OR = 0.956), duration of hypertension (P = 0.022, OR = 1.085), and post-treatment IL-6 levels (P = 0.043, OR = 1.030).</p><p><strong>Conclusion: </strong>Minimally invasive puncture and drainage offer superior neurological recovery, reduced inflammatory response, and improved long-term prognosis compared to traditional craniotomy in the treatment of hypertensive intracerebral hemorrhage.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Syntax score and percutaneous coronary intervention in diabetic patients with renal insufficiency.","authors":"Minjian Peng, Tao Ye, Kai Lan, Bo Xiong, Long Xia, Xunshi Ding, Chunbin Wang, Yingzhong Chen, Lin Cai","doi":"10.62347/VGPJ3431","DOIUrl":"10.62347/VGPJ3431","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between residual Syntax score (rSS) and long-term prognosis in diabetic patients with renal insufficiency undergoing percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>In this retrospective study, we included 510 patients with coronary heart disease, diabetes, and renal insufficiency who received PCI at the Third People's Hospital of Chengdu from July 2018 to December 2020. Patients were divided into three groups based on their eGFR levels: 113 patients with eGFR ≥ 60 mL/min/1.73 m², 256 patients with eGFR between 30 and 60 mL/min/1.73 m², and 141 patients with eGFR < 30 mL/min/1.73 m². Revascularization was quantified using the residual SYNTAX score (rSS), with an rSS > 8 indicating incomplete revascularization. We collected baseline data on cardiovascular adverse events and followed up with patients for 12 months, analyzing the correlations between rSS and biochemical markers such as blood glucose, uric acid, urea, serum creatinine, and eGFR, as well as the relationship between major adverse cardiovascular events (MACE) and rSS.</p><p><strong>Results: </strong>Univariate analysis identified myocardial infarction (MI), β-blocker use, and follow-up duration as factors significantly associated with the long-term prognosis of diabetic patients with renal insufficiency after PCI (P < 0.05). MI (OR=3.053, P=0.009), β-blocker use (OR=3.134, P=0.009), and follow-up duration (OR=0.998, P=0.05) were independent risk factors for long-term prognosis in these patients. rSS was positively correlated with blood glucose (r=0.973, P=0.000), uric acid (r=0.933, P=0.000), urea (r=0.907, P=0.000), serum creatinine (r=0.588, P=0.000), and eGFR (r=0.623, P=0.000). Syntax score was also positively correlated with long-term prognosis (OR=0.138, P=0.001).</p><p><strong>Conclusion: </strong>The rSS is a valuable tool for evaluating independent risk factors such as incomplete revascularization, MI, β-blocker use, and follow-up duration, all of which are positively correlated with the long-term prognosis of diabetic patients with renal insufficiency after PCI.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of prostigmin tests in the diagnosis of myasthenia gravis: a meta-analysis.","authors":"Juan Chen, Feng Qiu","doi":"10.62347/UBDB9601","DOIUrl":"10.62347/UBDB9601","url":null,"abstract":"<p><p>Myasthenia gravis (MG) is an acquired autoimmune disease diagnosed based on clinical manifestations, muscle fatigue tests, prostigmin tests, serum antibody tests, and neuroelectrophysiological examination. This study conducted a comprehensive search of PubMed, Web of Science, Scopus, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, WanFang, Chinese Periodical Database, Chinese Bio-Medicine Database, VIP, and DuXiu Database to identify relevant studies on the accuracy of prostigmin tests for diagnosing MG, covering publications from 1941 to 2021. Ten studies met the inclusion criteria and were included in the meta-analysis. The analysis found no heterogeneity caused by threshold effects but identified heterogeneity due to non-threshold effects. The combined sensitivity was 0.861 (95% CI: 0.831-0.888), and the combined specificity was 0.844 (95% CI: 0.816-0.870). The combined positive likelihood ratio was 5.496 (95% CI: 1.454-20.77), and the combined negative likelihood ratio was 0.237 (95% CI: 0.123-0.455). The area under the curve for diagnostic accuracy was 0.88 (95% CI: 0.84-0.90), with Q* = 0.8520. The combined diagnostic odds ratio was 19.344 (95% CI: 4.327-86.488). In conclusion, the prostigmin test demonstrated good diagnostic value for MG.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}