American journal of translational research最新文献

{"title":"Two-dimensional speckle tracking imaging and tissue Doppler imaging can predict subclinical left ventricular systolic and diastolic dysfunctions after chemotherapy for breast cancer.","authors":"Haifei Niu, Zijian Ma, Shaoshi Yang, Xiaofei Shen, Huajie Ding, Fengling Yuan","doi":"10.62347/GWCJ5941","DOIUrl":"https://doi.org/10.62347/GWCJ5941","url":null,"abstract":"<p><strong>Objective: </strong>This research primarily analyzes the clinical application of two-dimensional speckle tracking imaging (2D-STI), real-time 3-dimensional echocardiography (RT-3DE), and tissue Doppler imaging (TDI) in evaluating left ventricular dysfunction associated with breast cancer (BC) chemotherapy-related cardiotoxicity.</p><p><strong>Methods: </strong>First, we selected 106 BC patients who received treatment in The Affiliated Hospital of Chengde Medical University as the research group, all of whom underwent anthracycline-based chemotherapy; another 100 healthy subjects were chosen as the control group. Conventional ultrasound was employed to detect the mitral annular plane systolic excursion (MAPSE), mitral valve orifice early diastolic blood flow velocity (E), and left atrial volume index (LAVI) in the study subjects. 2D-STI was utilized to measure the global longitudinal strain (GLS) of the left ventricle, RT-3DE to measure left ventricular ejection fraction (LVEF), and TDI to measure the ratio of E to the average early diastolic mitral annulus velocity (E/e'), as well as systolic and early diastolic tissue velocities at the lateral wall of the mitral annulus and the ventricular septum (lateral s', septal s', lateral e', and septal e'). Left ventricular dysfunction was analyzed in both groups, and potential influencing factors were discussed.</p><p><strong>Results: </strong>The data revealed markedly lower GLS, MAPSE, E, lateral e', and septal e' in the research group compared to the control group. GLS<15.02% and LVEF<53% were defined as left ventricular systolic dysfunction. In comparison with the control group, the GLS and LVEF abnormality rates were evidently higher in the research group. No left ventricular diastolic dysfunction was observed in patients in both groups. Additionally, the dose of anthracyclines was a potential influencing factor for left ventricular dysfunction.</p><p><strong>Conclusions: </strong>2D-STI and TDI have certain predictive implications for the occurrence of subclinical left ventricular systolic and diastolic dysfunctions after BC chemotherapy. Furthermore, high-dose anthracyclines might lead to left ventricular dysfunction.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1087-1096"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Solifenacin combined with Mirabegron in treating overactive bladder in female patients following bladder instillation for bladder cancer.","authors":"Lichao Zhang, Yinghua Chen, Huasheng Liao","doi":"10.62347/BXQN5596","DOIUrl":"https://doi.org/10.62347/BXQN5596","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and safety of Solifenacin combined with Mirabegron in treating overactive bladder (OAB) in female patients following bladder instillation for bladder cancer.</p><p><strong>Methods: </strong>A total of 62 female patients who developed OAB after undergoing transurethral resection of bladder tumor (TURBT) and subsequent intravesical chemotherapy with pirarubicin were enrolled from the Department of Urology at Guangzhou Twelfth People's Hospital. Patients were divided into two groups according to the method of treatment. The control group received Solifenacin, while the observation group received a combination of Solifenacin and Mirabegron. Pre- and post-treatment assessments included voiding frequency, Overactive Bladder Symptom Score (OABSS), urodynamic parameters, Incontinence Quality of Life (I-QOL) scores, and adverse reactions.</p><p><strong>Results: </strong>Both groups showed a significant reduction in 24-hour voiding frequency and average nocturia after treatment (P<0.05), with the observation group exhibiting a more pronounced decrease compared to the control group (P<0.05). Post-treatment evaluations revealed lower OABSS and maximum detrusor pressure during the storage phase in both groups, along with an increase in the initial sensation of bladder filling volume and maximum bladder capacity (P<0.05). The observation group demonstrated more significant improvements in OABSS and maximum detrusor pressure during the storage phase, as well as higher initial bladder sensation volume and maximum bladder capacity compared to the control group (P<0.01).</p><p><strong>Conclusion: </strong>The combination of Mirabegron and Solifenacin offers superior therapeutic effects in female patients with OAB following bladder instillation for bladder cancer, significantly improving patients' quality of life without adverse effects.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1144-1152"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and evaluation of a predictive model for radiation-induced lung injury in lung cancer: a meta-analysis.","authors":"Min Peng, Zhiwei Sun, Jing Zhang","doi":"10.62347/CCZZ3986","DOIUrl":"https://doi.org/10.62347/CCZZ3986","url":null,"abstract":"<p><strong>Objective: </strong>To construct and evaluate a predictive model for radiation-induced lung injury (RILI) in lung cancer patients based on a meta-analysis of observational studies.</p><p><strong>Methods: </strong>A systematic search was conducted across various databases to identify observational studies on the prevalence and risk factors of RILI in lung cancer from the inception of each database up until June 2024. Meta-analysis was performed using Review Manager 5.3 software to calculate the latest prevalence data and pooled risk values for significant risk factors associated with RILI. A logistic regression model was developed using the natural logarithmic transformation of the combined risk values. External validation was performed with 180 lung cancer patients who underwent radiotherapy at Yinzhou Affiliated Hospital from July 2023 to June 2024. The predictive performance of the model was assessed using the area under the receiver operating characteristic (ROC) curve (AUC), and clinical practicability was evaluated by decision curve analysis.</p><p><strong>Results: </strong>A total of 27 studies were included in the analysis. The meta-analysis revealed that the prevalence of RILI in lung cancer patients was 33.0% (95% confidence interval [CI]: 23.0%-42.0%). Key risk factors identified for RILI included age, mean lung dose (MLD), volume of the lung receiving P20 Gray (V20), chronic obstructive pulmonary disease (COPD), radiotherapy dose, and volume of normal lung spared from irradiation at doses > 5 Gy (AVS5). The combined odds ratios (ORs) for these factors were 2.42 (95% CI: 1.08, 5.43) for age, 1.31 (95% CI: 1.16, 1.48) for MLD, and 1.64 (95% CI: 1.02, 2.64) for V20, among others. The resulting predictive model was: Logit(P) = -0.955 + 0.884X1 + 0.270X2 + 0.495X3 + 1.688X4 + 1.147X5 - 1.966X6, where X1, X2, X3, X4, X5, and X6 represent age, MLD, V20, COPD, radiotherapy dose, and AVS5, respectively. The model's AUC was 0.875 (95% CI: 0.799-0.951), with a sensitivity of 83.3% and specificity of 91.7%.</p><p><strong>Conclusion: </strong>Age, MLD, V20, COPD, radiotherapy dose, and AVS5 are significant risk factors for RILI in lung cancer patients. The constructed predictive model based on these factors demonstrates strong performance, with good evaluation results, making it useful for clinical risk assessment and management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"722-735"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified oral implant restoration improves dental aesthetics, function, and patient satisfaction in maxillary anterior tooth loss.","authors":"Fang Liu, Yu-Hong Wang, Yan-Jie Xiong, Yi-Liang Ni","doi":"10.62347/BDFY3122","DOIUrl":"https://doi.org/10.62347/BDFY3122","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of modified oral implant restoration in patients with maxillary anterior tooth loss.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 98 patients (119 affected teeth) with maxillary anterior tooth loss from August 2021 to November 2023. Among these, 50 cases (63 affected teeth) received modified oral implant restoration (research group), while 48 cases (56 affected teeth) underwent routine dental restoration (control group). Treatment efficacy, safety, peri-implant bone resorption, periodontal pocket depth, dental aesthetics (Pink Esthetic Score, PES; White Esthetic Score, WES), masticatory function, oral function recovery, and patient satisfaction were compared between the two groups.</p><p><strong>Results: </strong>The research group demonstrated a significantly higher rate of excellent and good outcomes, with superior PES and WES scores and greater patient satisfaction compared to the control group. Additionally, the research group exhibited a significantly lower incidence of adverse events, reduced peri-implant bone resorption, and shallower periodontal pocket depths compared to the control group. Furthermore, masticatory function and oral function recovery were also notably better in the research group.</p><p><strong>Conclusions: </strong>Modified oral implant restoration for maxillary anterior tooth loss can effectively enhance restoration outcomes, improve dental aesthetics, and promote better masticatory function and patient satisfaction. It also helps prevent peri-implant bone resorption and gingival atrophy, lowers the risk of adverse events, and supports oral function recovery, making it a valuable clinical option.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"983-991"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondrogenesis in primitive tracheal neocartilage: insights from 3D-printed silicone grafts in a large-scale animal model.","authors":"Sen-Ei Shai, Yi-Ling Lai, Yi-Wen Hung, Chi-Wei Hsieh, Kuo-Chih Su, Chun-Hsiang Wang, Te-Hsin Chao, Yung-Tsung Chiu, Chia-Ching Wu, Shih-Chieh Hung","doi":"10.62347/AFVA1238","DOIUrl":"https://doi.org/10.62347/AFVA1238","url":null,"abstract":"<p><strong>Objectives: </strong>Tracheal cartilage has limited regenerative potential in adults, posing a significant challenge for tracheal repair. Here, we observed marked neocartilage growth in a porcine model after transplanting it with a three-dimensional (3D)-printed silicone tracheal graft.</p><p><strong>Methods: </strong>Virtual silicone tracheal grafts of 2 cm in length were first generated using a 3D printer, and simulated a 3-month-old porcine trachea based on data from physical stress tests. After a segmental resection, a graft underwent end-to-end anastomosis at both the proximal and distal tracheal sections. Neotissue samples were later examined macroscopically, and their histologic properties were assessed based on results from the following: protein expression using H&E staining, alcian blue and safranin O/fast green staining for glycosaminoglycans (GAGs), and immunohistochemistry (IHC) assays for Sox9, type II collagen, aggrecan, and proliferating cell nuclear antigen (PCNA).</p><p><strong>Results: </strong>These primitive cartilages displayed chondrogenesis with an initial surplus of chondrocytes, evolving into a mature, stable state with cartilage corrosion facilitated by interim perichondrium-derived chondro-modulators, like perichondrial papillae (PPs), preresorptive layers (PRLs), and vascular canals (VCs). Results of alcian blue staining revealed the removal of matrix degradation products, specifically in the vicinity of the mucosal and submucosal glands.</p><p><strong>Conclusions: </strong>Chondrogenesis underwent an initial burst of growth together with the perichondrium, constituting a gradual consolidation process. Such a consolidation was supported by the emission of matrix degradation products in the mucosa and submucosa. To summarize our results, we propose a four-stage scheme to characterize the regenerative chondrogenesis of tracheal neocartilage.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"856-867"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation indices for predicting hypertensive pregnancy disorders.","authors":"Xuejun Kou, Qirong Li, Zhonggui Pan, Jing Yang","doi":"10.62347/NBXU9802","DOIUrl":"https://doi.org/10.62347/NBXU9802","url":null,"abstract":"<p><strong>Objectives: </strong>To study the correlation between coagulation function indicators at 28-34 weeks of gestation and the occurrence, progression, and severity of hypertensive disorders in pregnancy (HDP), and to explore their potential predictive value for HDP. By analyzing the changes in coagulation function indicators during pregnancy, HDP can be detected early, the progression of HDP can be delayed, and the prognosis of mothers and infants can be improved.</p><p><strong>Methods: </strong>This retrospective analysis encompassed 300 pregnant women who underwent antenatal examinations at the obstetrics outpatient department of Jinan Maternity and Child Care Hospital between October 2020 and October 2023. A total of 182 pregnant women diagnosed with HDP were selected as the observation group. Meanwhile, 118 healthy pregnant women from the same period served as the control group. General clinical data of all participants, such as age, gestational age, number of pregnancies, and number of deliveries, were collected. After an overnight fast, blood samples were drawn from all participants and immediately sent for testing to assess coagulation function indicators. Subsequently, these indicators were analyzed to explore their potential predictive value for the occurrence and severity of HDP.</p><p><strong>Results: </strong>Platelet count (PLT), thrombin time (TT), and fibrinogen (Fib) were identified as independent prognostic factors for pregnant women with HDP. Additionally, pregnant women with HDP had a higher incidence of premature delivery, full-term birth, vaginal delivery, cesarean section, postpartum hemorrhage, fetal growth restriction, neonatal asphyxia, and perinatal death.</p><p><strong>Conclusion: </strong>PT (Prothrombin Time), activated partial thromboplastin time (APTT), TT, Fib, and international normalized ratio can reflect the severity of hypertensive disorders in pregnancy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1106-1113"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative dynamic contrast-enhanced MRI parameters effectively predict treatment efficacy of neoadjuvant chemotherapy in breast cancer.","authors":"Ling Xu, Fangfang Zhou, Lianzi Su, Longsheng Wang","doi":"10.62347/GTIX2261","DOIUrl":"https://doi.org/10.62347/GTIX2261","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the predictive value of quantitative DCE-MRI parameters for estimating the treatment efficacy of neoadjuvant chemotherapy (NACT) in breast carcinoma (BC).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 178 pathologically confirmed cases of BC, diagnosed via puncture biopsy, at The Second Affiliated Hospital of Anhui Medical University between January 2019 and June 2023. All patients received preoperative NACT. Based on postoperative pathological inspection results, 53 patients with grade IV-V pathological responses were included in the major histological response (MHR) group, and the remaining 125 with grade I-III pathological responses were assigned to the non-major histological response (NMHR) group. The pre- and post-chemotherapy early-phase enhancement rate (E₁), peak enhancement rate (E_max), and time to peak (T_max) on DCE-MRI were compared between the two patient cohorts. Quantitative parameters such as volume transfer constant (K^trans), rate constant (K_ep) and extravascular extracellular volume fraction (V_e) were obtained, and the post-NACT maximum tumor diameter (D-max) reduction rate and tumor volume reduction rate (TVRR) were calculated. Furthermore, the predictive efficacy of pre- and post-NACT quantitative DCE-MRI parameters for treatment responses was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The MHR group showed statistically higher post-NACT D-max reduction rate and TVRR than the NMHR group. The two patient cohorts were similar in pre-chemotherapy K_ep, but the pre-chemotherapy K^trans and V_e were lower in MHR; the post-chemotherapy K^trans, K_ep and V_e were all statistically different between groups (P < 0.05). The MHR group presented markedly lower E₁ and E_max values and statistically longer T_max compared to the NMHR group after NACT (all P < 0.05). The pre-NACT quantitative DCE-MRI parameters demonstrated limited prediction performance, with V_e showing the highest efficacy (AUC = 0.612); in contrast, post-NACT quantitative DCE-MRI parameters exhibited improved predictive accuracy, with K^trans demonstrating the best predictive performance (AUC = 0.801).</p><p><strong>Conclusions: </strong>The pre-NACT quantitative DCE-MRI parameters are not effective in predicting the therapeutic outcome of NACT. However, the post-NACT DCE-MRI parameters provide accurate and reliable predictions of pathological responses, with K^trans showing the highest predictive value and considerable clinical applicability.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1039-1048"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Prolyl 3-Hydroxylase 1 (P3H1) in tumor development and prognosis: a pan-cancer analysis with validation in colonic adenocarcinoma.","authors":"Yanqin Chen, Moazzam Ali, Muhammad Bilal Tayyab, Muhammad Majid Nazir, Muhammad Umar, Salman Khan, Danyah Mohamed Ismail, Mostafa A Abdel-Maksoud, Hossam Ebaid, Abdulaziz Alamri, Saeedah Almutairi, Taghreed N Almanaa, Bushra Hafeez Kiani","doi":"10.62347/SUVC1606","DOIUrl":"https://doi.org/10.62347/SUVC1606","url":null,"abstract":"<p><strong>Background: </strong>Cancer is a multifaceted disease characterized by unregulated cell proliferation, evasion of apoptosis, and metastasis. Recent studies have highlighted the importance of extracellular matrix remodeling and post-translational modifications in tumorigenesis. Prolyl 3-hydroxylase 1 (P3H1), an enzyme involved in collagen hydroxylation, has gained attention for its role in cancer progression.</p><p><strong>Methods: </strong>This study investigates P3H1 expression, prognostic value, and functional relevance across multiple human cancers using a combination of bioinformatic and experimental approaches.</p><p><strong>Results: </strong>Using The Cancer Genome Atlas (TCGA) data from TIMER2.0 and UALCAN databases, we observed a significant upregulation of P3H1 mRNA and protein in various cancers. Prognostic analysis using GEPIA2 and KM plotter revealed that high P3H1 expression correlates with poorer overall survival in colon adenocarcinoma (COAD), kidney renal clear cell carcinoma (KIRC), and liver hepatocellular carcinoma (LIHC). Further, genetic and promoter methylation analyses showed low mutation frequencies and reduced methylation of P3H1 in specific cancer types. Functional and pathway enrichment analyses indicated that P3H1 is involved in collagen formation, endoplasmic reticulum activity, and pathways such as ECM-receptor interaction and PI3K-Akt signaling. Validation by enzyme linked immunosorbent assay in COAD patient serum samples demonstrated significantly elevated P3H1 levels compared to healthy controls, with an AUC approaching 1.0 by receiver operating characteristic (ROC) curve analysis. This suggests its potential as a diagnostic biomarker. Additionally, functional experiments were conducted in COAD cells to assess P3H1's role in tumorigenesis. Knockdown of P3H1 in HCT116 cells resulted in a significant reduction in cell proliferation, colony formation, and migratory abilities of these cells.</p><p><strong>Conclusion: </strong>These findings emphasize P3H1's relevance in COAD, KIRC, and LIHC pathogenesis and possible utility in clinical diagnosis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"770-790"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nursing risk management on treatment compliance and family psychological status in pediatric patients with idiopathic thrombocytopenic purpura.","authors":"Dan Chen, Wei Zhang","doi":"10.62347/WGMP4124","DOIUrl":"https://doi.org/10.62347/WGMP4124","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of nursing risk management on treatment adherence and family psychological status in pediatric idiopathic thrombocytopenic purpura (ITP).</p><p><strong>Methods: </strong>In this retrospective study, a total of 102 children with ITP admitted to Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University from January 2021 to March 2024 were selected as the research subjects and divided into two groups according to the order of admission and the different nursing protocols, with 50 cases in the control group (routine nursing management) and 52 cases in the observation group (risk management along with routine nursing care). Comparisons were made between the two groups of children in terms of treatment adherence, symptom improvement after intervention, time to symptom relief, length of hospitalization, platelet counts, incidence of rebleeding, family psychological status, and family satisfaction with care.</p><p><strong>Results: </strong>The compliance in the observation group was significantly higher than that in the control group (P<0.05). The scores of hemacelinosis, hemorrhage, and febrile symptoms in both groups at 7 days after admission were notably lower than those at admission (all P<0.05), with the observation group showing significantly lower scores than the control group (P<0.05). The duration of symptom relief and the length of hospitalization in the observation group were considerably shorter than those in the control group (P<0.05). The incidence of platelet counts below 50×10⁹/L three months after discharge and the incidence of rebleeding in the observation group were significantly lower than those in the control group (P<0.05). Three months after discharge, the families in both groups showed significant reductions in anxiety and depression compared to admission (P<0.05), with the observation group showing milder negative emotions than the control group (P<0.05). The overall satisfaction rate in the observation group was higher than that of the control group (P<0.05).</p><p><strong>Conclusion: </strong>Nursing risk management improves treatment adherence in pediatric ITP, reduces negative emotions in families, and increases family satisfaction with care.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1049-1056"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between β2-microglobulin level and risk of cardiovascular events and prognosis in hemodialysis patients.","authors":"Peng Qiu, Chun-Lei Lu, Yan-Ling Wang, Wei Wang","doi":"10.62347/FLPF7627","DOIUrl":"https://doi.org/10.62347/FLPF7627","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the effect of β2-microgolobulin (β2-MG) on the occurrence of cardiovascular events (CVE) in hemodialysis patients and its relationship with prognosis.</p><p><strong>Methods: </strong>In this retrospective study, we included 102 hemodialysis patients treated at Jinan People's Hospital Affiliated with Shandong First Medical University from September 2020 to January 2023. Clinical and follow-up data were collected. Logistic regression was used to evaluate the relationship between β2-MG and CVEs, while Cox proportional hazards regression analysis was used to assess the possible correlation between β2-MG and prognosis.</p><p><strong>Results: </strong>CVEs occurred in 41 of the 102 patients (40.20%). Of the patients, 72 patients survived, and 30 patients died, with an average survival time of 22.47±7.41 months (range: 7-38 months). Univariate analysis revealed no significant differences in age, albumin, serum soluble growth stimulating expression gene 2 protein (ST2), β2-MG, or urea clearance index (Kt/V) between the CVE group and the non-CVE group, nor between the death and survival groups (<i>P</i>>0.05). However, logistic regression analysis showed that elevated serum ST2 and β2-MG levels >30.1 mg/L were independent risk factors for CVE in hemodialysis patients (<i>P</i><0.05). Cox regression analysis revealed that an increase in β2-MG level was an independent risk factor for mortality in these patients (OR=3.385, <i>P</i><0.05). Survival analysis demonstrated a significant difference in survival among patients with different β2-MG levels (Log-rank²=18.230, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>Elevated β2-MG level is an independent risk factor for CVEs and mortality in hemodialysis patients, serving as an effective indicator for predicting the occurrence and prognosis of these outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1428-1436"},"PeriodicalIF":1.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}