American journal of translational research最新文献

{"title":"Collateral circulation significantly improves prognosis in cerebral infarction: a meta-analysis.","authors":"Huafei Liu, Nengyun Yao, Haoyue Hu, Zhiwen Xiao, Yidi Tang, Songlin Tang","doi":"10.62347/XCXK6861","DOIUrl":"10.62347/XCXK6861","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the association between collateral circulation and prognosis in patients with cerebral infarction through a meta-analysis.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases to identify studies examining the relationship between collateral circulation and outcomes in cerebral infarction. Studies were screened based on predefined inclusion and exclusion criteria. Data were extracted and pooled using standard meta-analytic techniques.</p><p><strong>Results: </strong>A total of 41 studies encompassing 10,510 patients were included. Meta-analysis revealed that good collateral circulation was significantly associated with a favorable prognosis (pooled odds ratio [OR] = 1.67, 95% confidence interval [CI]: 1.35-2.07; P < 0.001). Subgroup analyses confirmed this association across different geographic regions and sample sizes.</p><p><strong>Conclusion: </strong>Collateral circulation is a critical determinant of prognosis in cerebral infarction. Enhancing collateral circulation may serve as a promising therapeutic strategy to improve clinical outcomes in affected patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4546-4561"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory training reduces postoperative pulmonary complications in elderly gynecological patients undergoing general anesthesia.","authors":"Yina Zhang, Fengcheng Cai, Zhiqiang Ruan","doi":"10.62347/VXSR1449","DOIUrl":"10.62347/VXSR1449","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of respiratory training in reducing postoperative pulmonary complications (PPCs) in elderly gynecological patients undergoing general anesthesia.</p><p><strong>Methods: </strong>A total of 240 elderly gynecological patients who underwent surgery under general anesthesia were included. Among them, 120 patients received standard postoperative care (control group), while the other 120 received additional respiratory training (research group). The incidence of PPCs, length of hospital stay, treatment costs, pulmonary function parameters, arterial blood gas indices, mean arterial pressure (MAP), and respiratory rate (RR) were compared between the two groups. Risk factors associated with PPCs were also identified through univariate and binary logistic regression analyses.</p><p><strong>Results: </strong>The research group had a significantly lower overall incidence of PPCs, shorter hospital stays, and reduced treatment costs compared to the control group (all P < 0.05). Postoperative pulmonary function was better preserved, and arterial blood gas parameters improved more markedly in the research group (both P < 0.05). Although MAP showed no significant change, RR was significantly lower (both P < 0.05). Regression analyses identified body mass index, and treatment modality as independent risk factors for PPCs.</p><p><strong>Conclusions: </strong>Respiratory training significantly reduces the risk of postoperative pulmonary complications in elderly gynecological patients undergoing general anesthesia and contributes to better recovery outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4612-4621"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DTI-ALPS index as a predictor of glymphatic system dysfunction in cerebral infarction.","authors":"Bomiao Lin, Yuh Yang Leong, Mazlyfarina Mohamad","doi":"10.62347/ANQP2661","DOIUrl":"10.62347/ANQP2661","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate glymphatic system (GS) dysfunction in patients with cerebral infarction using diffusion tensor imaging - along the perivascular space (DTI-ALPS), and to investigate factors associated with glymphatic function impairment following stroke.</p><p><strong>Methods: </strong>A retrospective study was conducted on 82 patients diagnosed with cerebral infarction at Zhujiang Hospital of Southern Medical University between July 2019 and June 2022. Based on 90-day modified Rankin Scale (mRS) scores, patients were categorized into a good prognosis group (n = 40) and a poor prognosis group (n = 42). Clinical data, National Institutes of Health Stroke Scale (NIHSS) scores, DTI-ALPS indices (L-ALPS, R-ALPS, mean-ALPS), 90-day mRS scores, and infarct location were compared between groups.</p><p><strong>Results: </strong>At admission, the L-ALPS, R-ALPS, and mean-ALPS values were significantly higher in the good prognosis group compared to the poor prognosis group (all P < 0.05). At 90 days post-onset, Hamilton Depression (HAMD) and Anxiety (HAMA) scores were significantly lower than baseline in the good prognosis group, indicating better psychological recovery compared to the poor prognosis group (both P < 0.05). Additionally, NIHSS scores were lower, while Glasgow Coma Scale (GCS) and activities of daily living (ADL) scores were higher in the good prognosis group (both P < 0.05). Logistic regression analysis identified L-ALPS, R-ALPS, mean-ALPS, 90-day mRS, ADL, and GCS scores as independent predictors of poor prognosis. Furthermore, ADL, 90-day mRS, and GCS scores were independently associated with GS dysfunction.</p><p><strong>Conclusion: </strong>Patients with poor prognosis after cerebral infarction exhibit significant GS dysfunction. This dysfunction correlates with the severity of neurological impairment, suggesting that glymphatic impairment is both a marker and a potential contributor to stroke outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4306-4314"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and adverse reactions of remimazolam and propofol in patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis.","authors":"Rong Wang, Weiwei Peng, Juncai Li, Fan Xiao, Xuefen Yuan, Salman Khan","doi":"10.62347/RKAA9956","DOIUrl":"10.62347/RKAA9956","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal (GI) endoscopy is crucial for detecting suspicious gastric lesions, screening for gastric cancer, and providing early diagnosis. With an aging population, an increasing number of elderly individuals require gastrointestinal endoscopy.</p><p><strong>Methods: </strong>Four databases were searched to acquire controlled clinical trials on the effects of remimazolam and propofol in patients undergoing GI endoscopy. A meticulous evaluation of the literature quality and data was then performed using Stata software.</p><p><strong>Results: </strong>Seventeen studies reported significantly lower respiratory depression in the experimental group compared to the control group (odds ratio: OR 0.28; 95% confidence interval (CI): 0.18-0.45; P<0.01). Injection pain (OR: 0.11; 95% CI: 0.06-0.20; P<0.01), hypotension (OR: 0.41; 95% CI: 0.33-0.52; P<0.01), and hypoxemia (OR: 0.38; 95% CI: 0.22-0.63; P<0.01) were also significantly lower in the experimental group. However, propofol was associated with improved sedation success (OR: 0.99; 95% CI: 0.98-1.00; P=0.048) and longer sedation time (SMD: 24.19; 95% CI: 14.60-33.79; P<0.01). Recovery time showed no significant difference between groups (SMD: -0.27; 95% CI: -1.46-0.92; P=0.657).</p><p><strong>Conclusion: </strong>This study suggests that both remimazolam and propofol are efficacious in patients undergoing gastrointestinal endoscopy. Remimazolam significantly reduces complications such as respiratory depression, injection pain, hypotension, and hypoxemia. However, propofol has advantages in improving sedation success and sedation time. These findings are supported by high-quality randomized controlled trials.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4362-4374"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of integrating surgical interventions with chemoradiotherapy in managing stage IIIC cervical cancer.","authors":"Xingshao Hu, Chenhong Ye, Jiaqiong Peng, Mingju Huang","doi":"10.62347/GLOU3149","DOIUrl":"10.62347/GLOU3149","url":null,"abstract":"<p><strong>Objective: </strong>This research is principally dedicated to exploring the therapeutic outcomes of integrating surgical intervention with chemoradiotherapy in patients diagnosed with stage IIIC cervical cancer (CC).</p><p><strong>Methods: </strong>A cohort of 141 patients with stage IIIC CC admitted to Chongqing University Three Gorges Hospital were enrolled. Among them, 47 patients underwent radical chemoradiotherapy alone (control group), while 94 patients received surgical intervention in addition to radical chemoradiotherapy (research group). Treatment outcomes were comprehensively evaluated, including short-term therapeutic response, safety profiles, radiotherapy-related complications, long-term treatment efficacy - measured by progression-free survival (PFS) and overall survival (OS) and quality of life (QOL). Univariate and multivariate analyses were performed to identify independent predictors of long-term treatment outcomes.</p><p><strong>Results: </strong>The research group exhibited significantly superior short-term efficacy compared to the control group. Additionally, the research group showed a notably lower rate of treatment-associated adverse events, but radiotherapy-induced complications occurred at a similar frequency as in the control group. Long-term outcomes, including PFS, OS, and QOL scores, were also significantly better in the research group. Both univariate and multivariate analyses identified body mass index (BMI) and treatment modality as independent prognostic factors for long-term outcomes in patients with stage IIIC CC.</p><p><strong>Conclusions: </strong>The integration of surgical intervention with radical chemoradiotherapy yields superior therapeutic outcomes compared to chemoradiotherapy alone in the management of stage IIIC cervical cancer, highlighting its potential as a more effective treatment strategy.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4351-4361"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDKN2A and matrix metalloproteinases: key regulators of cellular senescence in squamous cell carcinoma.","authors":"Qiuju Tian, Minghui Wang, Faiqa Mubeen, Ayesha Sundas, Rida Naz, Xin Hu, Xi Chen","doi":"10.62347/FKDS7259","DOIUrl":"10.62347/FKDS7259","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the role of cellular senescence in the progression of squamous cell carcinoma (SCC) and to identify key senescence-associated biomarkers and pathways that contribute to tumor aggressiveness.</p><p><strong>Methods: </strong>RNA sequencing data from SCC and normal skin tissues (GSE191334) were analyzed using the DESeq2 package to identify differentially expressed genes (DEGs). Upregulated DEGs were cross-referenced with the CellAge database to identify senescence-related biomarkers. Functional enrichment analyses were conducted using EnrichR, GeneCodis4, and KEGG databases. Protein-protein interaction networks were mapped using STRING, and mutational profiling of CDKN2A was performed via the G2P portal and UCSC Xena.</p><p><strong>Results: </strong>A total of 1,448 genes were upregulated and 1,700 downregulated in SCC. Among these, 38 upregulated genes were associated with cellular senescence. Notably, CDKN2A was prominently expressed, suggesting a stress-induced senescence response. CDKN2A, along with MMP3 and MMP12, formed central hubs within interaction networks, implicating them in extracellular matrix remodeling and tumor invasiveness. Enrichment analyses highlighted activation of epithelial-to-mesenchymal transition (EMT), inflammatory signaling, and senescence-associated secretory phenotype (SASP). Immune-modulatory genes such as ULBP2 and IL6 were also elevated. Mutation analysis revealed alterations in the CDKN2A-encoded p16^INK4a^, potentially disrupting its tumor-suppressive functions.</p><p><strong>Conclusions: </strong>Cellular senescence in SCC exhibits a dual role - initially tumor-suppressive, later promoting invasion and metastasis. Key biomarkers such as CDKN2A and MMPs may serve as therapeutic targets. These findings lay the groundwork for future translational research to improve SCC diagnosis and treatment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4573-4589"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy with otilonium bromide and trimebutine maleate demonstrates significant clinical advantages in irritable bowel syndrome patients.","authors":"Dingfeng Chen, Dongqiong Ni, Haiyan Yang","doi":"10.62347/JFCI2618","DOIUrl":"10.62347/JFCI2618","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of combined otilonium bromide (OB) and trimebutine maleate (TM-906) therapy in patients with irritable bowel syndrome (IBS).</p><p><strong>Methods: </strong>Data from 105 IBS patients treated at the Affiliated Hospital of Shaoxing University were retrospectively analyzed. Patients were divided into two groups: the control group (n=50), receiving OB alone, and the observation group (n=55), receiving both OB and TM-906. A comprehensive set of data, including treatment efficacy, safety profiles, clinical symptom improvements, serum markers, and quality of life, were collected from both groups.</p><p><strong>Results: </strong>The observation group exhibited significantly higher treatment efficacy and greater improvement in quality of life compared to the control group (P<0.05). The incidence of adverse reactions was similar between groups (7.27% vs. 6.00%, P>0.05). Additionally, the observation group experienced faster symptom relief and a more substantial reduction in inflammatory markers post-treatment (P<0.05).</p><p><strong>Conclusions: </strong>Combined therapy with OB and TM-906 is a safe and effective treatment for IBS, offering quicker symptom relief and substantial improvement in quality of life.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4859-4866"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of Braden scale combined with hemoglobin and hematocrit for oral mucosal pressure injury risk in ICU patients.","authors":"Fulin Hu, Lunlan Li, Yelan Gao, Caipeng Yue, Chengwei Xu, Changyu Jin","doi":"10.62347/XJAM4799","DOIUrl":"10.62347/XJAM4799","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the predictive value of the Braden scale and laboratory indicators for oral mucosal pressure injury (OMPI) in patients admitted to the Emergency Intensive Care Unit (ICU).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 238 intubated patients admitted to the First Affiliated Hospital of Anhui Medical University. Patients were divided into a training set (n = 166) and a validation set (n = 72). The training set was further classified into OMPI (n = 67) and non-OMPI (n = 99) groups. Clinical data were compared between the two groups, and a logistic regression model was constructed to develop a predictive nomogram. Model performance was assessed using discrimination and calibration metrics, and internal validation was performed with the validation cohort.</p><p><strong>Results: </strong>The training and validation sets were comparable. Significant predictors of OMPI included Braden scale score (P < 0.001), ICU length of stay (P < 0.001), intubation duration (P = 0.039), and hemoglobin (P < 0.001). Logistic regression identified Braden scale, intubation duration, hemoglobin, and hematocrit as independent risk factors.</p><p><strong>Conclusion: </strong>The combination of Braden scale score, hemoglobin, and hematocrit demonstrated good predictive value for OMPI in EICU patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4744-4753"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for in-hospital heart failure in patients with acute myocardial infarction and construction of predictive models.","authors":"Binbin Zhang, Fengqiu Sui, Peng Yuan","doi":"10.62347/ZDQC6925","DOIUrl":"10.62347/ZDQC6925","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors and develop a predictive model for heart failure in patients with acute myocardial infarction (AMI).</p><p><strong>Methods: </strong>Clinical data from 312 AMI patients were retrospectively collected. Patients were divided into a Heart failure group and a non-heart failure group based on the occurrence of heart failure during hospitalization. Comparative analyses were performed between the two groups. Multivariate logistic regression analysis was used to identify risk factors of in-hospital heart failure. A nomogram prediction model was constructed using R software. The model's performance was evaluated by receiver operating characteristic (<i>ROC</i>) curve analysis, 10-fold cross-validation (repeated 100 times), and decision curve analysis.</p><p><strong>Results: </strong>Among the 312 AMI patients, 94 (30.13%) developed heart failure during hospitalization. Multivariate logistic regression identified advanced age (<i>OR</i> = 2.158, <i>P</i> = 0.004), diabetes (<i>OR</i> = 1.964, <i>P</i> = 0.002), higher Gensini score (<i>OR</i> = 2.869, <i>P</i> = 0.001), left ventricular ejection fraction (LVEF) < 50% (<i>OR</i> = 2.581, <i>P</i> = 0.007), and elevated N-terminal pro B-type natriuretic peptide (NT-proBNP) levels (<i>OR</i> = 3.593, <i>P</i> < 0.001) as risk factors for heart failure in AMI patients. The constructed nomogram model demonstrated an area under the <i>ROC</i> curve (AUC) of 0.882, indicating good discriminative ability. The model demonstrated high stability through 100 repetitions of 10-fold cross-validation. Decision curve analysis confirmed its clinical utility.</p><p><strong>Conclusion: </strong>In-hospital heart failure in AMI patients is associated with older age, diabetes, elevated Gensini score, reduced LVEF, and increased NT-proBNP levels. The developed nomogram model effectively predicts the risk of heart failure in this population and may assist in early clinical risk stratification.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4323-4330"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum magnesium levels as a predictor of coronary artery stenosis and their association with oxidative stress biomarkers.","authors":"Hasidaer Midilibieke, Ying Gao, Juledezi Hailati, Yunchun Yang, Lei Zhang, Madina Mahesutihan, Jiao Wang, Meijuan Zheng, Muhuyati, Zhiqiang Liu","doi":"10.62347/APEX4060","DOIUrl":"10.62347/APEX4060","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between serum magnesium (Mg) levels and the presence of coronary artery stenosis, as well as their correlation with oxidative stress biomarkers malondialdehyde (MDA) and superoxide dismutase (SOD).</p><p><strong>Methods: </strong>In this retrospective study, a total of 42 patients diagnosed with coronary artery stenosis at the First Affiliated Hospital of Xinjiang Medical University between January 2022 and October 2024 were included as the coronary artery experimental group, while another 42 cases with no significant stenosis confirmed by coronary angiography during the same period served as the control group. Demographic and clinical characteristics, as well as serum Mg levels and oxidative stress markers were compared between the two groups. The correlations between serum Mg levels and both coronary artery stenosis and oxidative stress factors (MDA and SOD) were analyzed using the Spearman rank correlation coefficient. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic performance of serum Mg levels on coronary artery stenosis.</p><p><strong>Results: </strong>There were no significant differences in the baseline demographic characteristics between the two groups (all P>0.05), including age, gender distribution, body mass index (BMI), educational background, smoking and alcohol consumption history, systolic blood pressure (SBP), diastolic blood pressure (DBP), DM course, fasting plasma glucose (FPG), glycated hemoglobin (GHb), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), creatinine (Cr), and blood urea nitrogen (BUN). The stenosis group had significantly lower serum Mg levels (1.57±0.37 vs. 2.02±0.33 mmol/L, P<0.001) and higher SOD (86.11±21.59 vs. 59.02±17.36 U/mL, P<0.001), while MDA was elevated in controls (24.52±8.33 vs. 18.82±6.37 nmol/mL, P=0.001). The ROC analysis of serum Mg levels for predicting coronary artery stenosis yielded an area under the curve (AUC) of 0.825 (95% CI: 0.757-0.923), with an optimal cutoff value of 1.88 mmol/L (standard error: 0.3265), achieving a sensitivity of 80% and specificity of 75%. Spearman correlation analysis demonstrated a negative association between Mg and MDA (r=-0.506, P=0.041) and a positive association with SOD (r=0.288, P=0.008) in patients with coronary stenosis.</p><p><strong>Conclusions: </strong>Lower serum magnesium levels are significantly associated with an increased risk of coronary artery stenosis. Moreover, reduced serum Mg correlates with elevated MDA levels and decreased SOD activity, indicating enhanced oxidative stress.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 6","pages":"4779-4787"},"PeriodicalIF":1.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}