American journal of translational research最新文献

{"title":"Serum levels of Galectin-1 and Galectin-3 for monitoring rheumatoid arthritis severity: a meta-analysis.","authors":"Chunyan Zhu, Yushi Li, Honglei Wang, Xiaomei Yang, Qingqing Wang","doi":"10.62347/XGUP6698","DOIUrl":"10.62347/XGUP6698","url":null,"abstract":"<p><strong>Background: </strong>Galectin-1 (Gal-1) and galectin-3 (Gal-3) have emerged as promising biomarkers for diagnosing and managing rheumatoid arthritis (RA). This study aims to synthesize current evidence through a systematic review and meta-analysis to evaluate the clinical effectiveness of serum Gal-1 and Gal-3 as biomarkers for monitoring disease severity and predicting clinical outcomes in RA patients.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search in PubMed, Web of Science, and the Cochrane Library, including studies published up to March 2024. Eleven observational studies were selected based on predefined inclusion criteria. The risk of bias in these studies was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Data synthesis and meta-analysis were performed using RevMan 5.3 software, with the study protocol registered at INPLASY (ID: 202460103).</p><p><strong>Results: </strong>The meta-analysis included 1213 participants (comprising 809 RA patients and 404 healthy controls) from 11 studies. Serum levels of Gal-1 and Gal-3 were significantly higher in RA patients compared to controls (MD=25.09 ng/ml, 95% CI: 24.18-26.00 ng/ml, P<0.00001; MD=30.51 ng/ml, 95% CI: 29.10-31.93 ng/ml, P<0.00001). Moreover, Gal-1 levels exhibited a positive correlation with RA disease activity markers, such as the Erythrocyte Sedimentation Rate (ESR) and the Disease Activity Score 28 (DAS28). The analysis demonstrated a correlation coefficient of r=0.24 (95% CI: 0.14-0.33, P<0.00001) between Gal-1 and RA disease activity, highlighting a notable association. Similarly, Gal-3 showed significant positive correlations with ESR (r=0.29, 95% CI: 0.18-0.40, P<0.00001), DAS28 (r=0.25, 95% CI: 0.13-0.37, P<0.00001), and C-reactive protein (CRP) (r=0.15, 95% CI: 0.05-0.26, P<0.00001). The overall correlation between circulating Gal-3 levels and RA disease severity indices was r=0.23 (95% CI: 0.16-0.29, P<0.00001).</p><p><strong>Conclusion: </strong>Gal-1 demonstrates significant potential as a biomarker for diagnosing and managing RA. Monitoring Gal-1 and Gal-3 levels may provide valuable insights into early disease assessment and progression, potentially improving treatment outcomes for RA patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3252-3260"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional electrical stimulation enhances motor control in stroke rehabilitation.","authors":"Yingjiao Liu, Wenjun Fu, Yejing Ren, Huiping Li, Ailian Chen","doi":"10.62347/THME3127","DOIUrl":"10.62347/THME3127","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effectiveness of functional electrical stimulation (FES) in enhancing motor control in stroke survivors.</p><p><strong>Methods: </strong>A retrospective study was conducted on clinical data from 150 stroke patients with lower-limb motor dysfunction, treated at Hunan Provincial People's Hospital from January 2023 to January 2024. Patients were divided into three groups: a control group (conventional rehabilitation), a CPN-FES group (conventional rehabilitation + calf muscle functional stimulation), and a TA-FES group (conventional rehabilitation + tibialis anterior functional stimulation). The data collected included F-wave latency and amplitude, H-reflex changes, lower-limb motor function, walking and balance abilities, mental status, and activities of daily living. The outcomes across the groups were compared to assess the efficacy of FES in improving motor control in stroke patients.</p><p><strong>Results: </strong>The study found that integrating electrical stimulation with early rehabilitation markedly enhanced stroke patients' recovery. After 8 weeks, improvements were observed in lower-limb motor function, walking and balance, cognitive status, and daily living activities. The CPN-FES group showed the greatest improvements, followed by the TA-FES group, while the control group demonstrated the least improvement. Additionally, FES therapy improved nerve conduction and reduced muscle spasticity, as evidenced by changes in F-wave and H-reflex measurements.</p><p><strong>Conclusion: </strong>The use of functional electrical stimulation in stroke rehabilitation appears to enhance motor control and improve functional outcomes. This approach merits further investigation in a clinical setting.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3889-3897"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rg3 exerts anticancer effects in lung cancer through metabolite Histon H3.","authors":"Huiyan Xiao, Yongcong Zhang, Banghui Zhang, Jian Wu, Xu Li","doi":"10.62347/YJZW4664","DOIUrl":"10.62347/YJZW4664","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of ginsenoside Rg3 on metabolites in lung cancer cells.</p><p><strong>Methods: </strong>A549 cells were inoculated into nude BALB/c mice. Ginsenoside Rg3 (0.2 mL) or normal saline was orally administered daily for 12 days. LC/MS-based metabolomics was performed to analyze the metabolite profiles across three groups.</p><p><strong>Results: </strong>In serum samples, 143 metabolites were significantly different between the model and ginsenoside Rg3 groups. In fecal samples, 44 metabolites differed significantly between the two groups. Levels of Lamin A/C and Histon H3 were upregulated in model tissues. Ginsenoside Rg3 treatment significantly inhibited the expression of Lamin A/C and Histon H3, suggesting inhibition of histidine metabolism activation in lung cancer. Furthermore, ginsenoside Rg3 or Lamin A knockdown inhibited histamine-induced proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in lung cancer cells.</p><p><strong>Conclusions: </strong>Ginsenoside Rg3 significantly altered the metabolic profile in lung cancer mice. Mechanistically, ginsenoside Rg3 downregulated Lamin A/C through histidine metabolic pathway and suppressed histamine-induced progression of lung cancer.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3994-4007"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High platelet distribution width affects the detection of fetal fraction of cell-free DNA detected by non-invasive prenatal testing.","authors":"Yu-Qiong Zhang, Long-Wei Qiao, Wen-Jing Li, Ya-Nan Wang, Jing-Jing Gao","doi":"10.62347/MTQT6463","DOIUrl":"10.62347/MTQT6463","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the effect of platelet distribution width (PDW) on fetal fraction (FF) of cell-free DNA (cfDNA) within non-invasive prenatal testing (NIPT) during pregnancy.</p><p><strong>Methods: </strong>The study subjects were pregnant women who voluntarily underwent NIPT and had antenatal examinations at the Affiliated Suzhou Hospital of Nanjing Medical University from January 2016 to January 2021. They underwent routine blood tests before and after NIPT. Univariate and multivariate regression models were used to evaluate the correlation between complete blood count indices and FF.</p><p><strong>Results: </strong>Multivariate linear regression analysis revealed that hemoglobin (Hb), white blood cell count (WBC), platelet count (PLT), red blood cell distribution width (RDW), PDW, and body mass index (BMI) were negatively correlated with FF, while the interval between the two tests was positively correlated with FF. Notably, PDW (standardized β: -0.097) was the second most significant factor after BMI (standardized β: -0.292). Further grouping by PDW showed that compared to PDW ≤ 12.0 fL, FF decreased by 0.070 (95% CI: -0.111 to -0.030; <i>P</i> = 0.001) and 0.191 (95% CI: -0.260 to -0.123; <i>P</i> < 0.001) in women with PDW levels of 12.1-15.0 fL and > 15.0 fL, respectively, showing a gradual decreasing trend (<i>P_trend</i> < 0.001).</p><p><strong>Conclusion: </strong>Higher PDW values altered the FF detection, with an observed decrease in FF as PDW levels increased.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3649-3657"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The multikinetic fusion feature of PPG was combined with MCNN_vision_transformer for diabetes detection.","authors":"Ming-Xia Xiao, An-Yao Zhang, Ting-Ting Jin, Shi-Dong Fang","doi":"10.62347/ZRMW1346","DOIUrl":"10.62347/ZRMW1346","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a chronic condition that significantly impacts the cardiovascular system and various other organs. Photoplethysmogram (PPG) signals have been shown to correlate with variations in vascular blood flow and the presence of atherosclerosis. To effectively explore the complex nonlinear relationship between PPG signals and diabetes, we propose an automatic detection model based on the fusion of PPG features.</p><p><strong>Methods: </strong>The proposed model consists of two main components: 1. Dynamic Fusion Feature Extraction: Short PPG signal window segments are processed using the SGR spatial encoding algorithm to extract dynamic fusion features. 2. Feature Representation Learning: Multi-scale convolutional layers (MCNN) are employed to learn feature representations, while the Vision Transformer (ViT) model is utilized to capture global contextual semantic features.</p><p><strong>Results: </strong>The model was trained and validated on a self-collected medical dataset. The experimental results demonstrate that the classification model, which integrates short time window information, significantly improves detection performance. Specifically, the multi-period sequence input model achieves an accuracy of 91.11%, with a Receiver Operating Characteristic (ROC) curve area of 0.9341, indicating strong diagnostic capability.</p><p><strong>Conclusion: </strong>This study is a retrospective case-control study that collected clinical data from three groups of people: those with normal glucose levels, those with poorly controlled diabetes, and those with well-controlled diabetes. The study aims to utilize deep learning algorithms for the early prevention and screening of diabetes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3951-3960"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum toxin type A injections demonstrate remarkable efficacy in treating hemifacial spasm in elderly patients.","authors":"Lihua Cao, Min Bai, Chao Li, Weiwei Sheng, Dingjie Zhou, Xiaolei Wang","doi":"10.62347/JQNB3235","DOIUrl":"10.62347/JQNB3235","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effectiveness of botulinum toxin type A (BTX-A) injections in elderly patients with hemifacial spasm (HFS).</p><p><strong>Methods: </strong>In this retrospective study, a total of 120 elderly patients diagnosed with HFS were recruited and divided into two groups: a research group (n=65) receiving multi-point BTX-A injections and a control group (n=55) undergoing conventional treatment. Comparative analyses were conducted to evaluate therapeutic efficacy, duration of efficacy, adverse reactions, Hamilton Anxiety Scale (HAMA) scores, and Hamilton Depression Scale (HAMD) scores between the two groups. Furthermore, factors influencing treatment outcomes in elderly HFS patients were investigated.</p><p><strong>Results: </strong>The research group demonstrated significantly higher overall efficacy, prolonged durations of therapeutic efficacy in grades II, III, and IV, a lower incidence of adverse reactions, and more pronounced improvements in HAMA and HAMD scores. Additionally, Cohen grading, HAMA and HAMD scores, and the treatment approach were independently correlated with treatment failure in elderly patients.</p><p><strong>Conclusion: </strong>Multi-point BTX-A injections are highly effective in treating HFS in elderly patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3674-3682"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiologic evaluation of the IntraSPINE non-fusion technique for lumbar degenerative disease.","authors":"Yang Li, Si-Peng Li, Ming-Zuo Guo, Lai-Zhou Ji, Meng Chen, Da-Yong Peng, Wen-Xiu Hou, Hao-Xuan Zhang","doi":"10.62347/VDDB8522","DOIUrl":"10.62347/VDDB8522","url":null,"abstract":"<p><strong>Objective: </strong>To compare the clinical and radiographic outcomes of the non-fusion IntraSPINE technique with patients receiving traditional lumbar fusion.</p><p><strong>Methods: </strong>A prospective study was conducted on patients with lumbar degenerative disease who failed to respond to conservative treatment. Clinical and radiologic evaluations were performed preoperatively and at 7 days, 6 months, and 12 months postoperatively. Clinical outcomes were assessed using the Japanese Orthopaedic Association (JOA) score, Visual Analogue Scale (VAS), and Oswestry Disability Index (ODI). Radiographic parameters included range of motion (ROM), posterior disc height (PDH), and foraminal height (FH) at the treated and adjacent segments.</p><p><strong>Results: </strong>Both groups demonstrated significant postoperative improvements in VAS, JOA, and ODI scores. However, the fusion group demonstrated complete loss of motion at the treated segment and increased motion at adjacent segments. In contrast, the non-fusion group retained partial ROM at the treated segment while maintaining adjacent segment motion close to preoperative levels. PDH and FH remained stable in the non-fusion group, whereas the fusion group experienced significant reductions in these measures at the adjacent segments.</p><p><strong>Conclusion: </strong>The IntraSPINE non-fusion technique yields clinical outcomes comparable to those of lumbar fusion, while preserving ROM, PDH, and FH in both the treated and adjacent segments. This preservation may reduce the risk of adjacent segment degeneration, supporting the use of IntraSPINE as a viable alternative to traditional fusion surgery.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3738-3752"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cullin family genes in rectal adenocarcinoma: expression, prognostic significance, and therapeutic implications.","authors":"Yifei Gao, Lei Yang, Ximo Wang","doi":"10.62347/UNVS8140","DOIUrl":"10.62347/UNVS8140","url":null,"abstract":"<p><strong>Objectives: </strong>Cullin family genes play a critical role in ubiquitin-mediated protein degradation and have been implicated in various cancers. However, their expression patterns, prognostic significance, and functional roles in rectal adenocarcinoma (READ) remain unclear. This study aims to comprehensively analyze the expression, prognostic value, and potential biological functions of culllin genes in READ.</p><p><strong>Methods: </strong>We analyzed the transcriptional expression of CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, and CUL9 in READ using publicly available databases, including UALCAN and HOA. The prognostic significance of CUL genes was evaluated using Kaplan-Meier survival analysis. Functional enrichment analysis was performed to determine the biological pathways associated with cullin gene expression. Additionally, siRNA-mediated knockdown of CUL genes was done to assess the effect on cell proliferation, migration, and colony formation.</p><p><strong>Results: </strong>The analysis revealed significant overexpression of cullin genes in READ compared to normal tissues. Survival analysis indicated that higher expression of specific CUL2 and CUL7 genes correlated with poor prognosis in READ patients. Functional enrichment analysis demonstrated that cullin genes were associated with diverse enrichment terms. In vitro experiments showed that siRNA-mediated knockdown of CUL2 and CUL47 led to a significant reduction in cell proliferation, migration, and colony formation, highlighting their potential oncogenic role in READ.</p><p><strong>Conclusion: </strong>This study provides novel insight into the role of cullin genes in READ, suggesting that CUL2 and CUL7 may be biomarkers and therapeutic targets. Further research is warranted to explore their underlying mechanisms and clinical applications in READ management.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3842-3861"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a predictive model for postoperative recurrence and metastasis in breast cancer using an artificial intelligence ultrasound breast system.","authors":"Xiuli Cheng, Lili Shen, Xinyu Tang, Fang Ma","doi":"10.62347/MECC4748","DOIUrl":"10.62347/MECC4748","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility and efficacy of developing a predictive model for postoperative recurrence and metastasis in breast cancer using the Artificial Intelligence Ultrasound Breast System (AIUBS).</p><p><strong>Methods: </strong>A retrospective study was conducted with 120 breast cancer patients who underwent surgery between January 2022 and December 2023. Patients were divided into two groups based on postoperative outcomes: recurrence/metastasis (n = 58) and non-recurrence/non-metastasis (n = 62). Logistic regression was used to identify independent predictors, and a nomogram model was constructed. Model performance was assessed using Receiver Operating Characteristic curves, calibration curves, and decision curve analysis (DCA). The optimal cutoff value was determined through confusion matrix analysis.</p><p><strong>Results: </strong>Univariate analysis identified lymph node metastasis (OR = 8.17, 95% CI: 3.51-18.99), estrogen receptor (ER) status (OR = 0.46, 95% CI: 0.21-0.99), and human epidermal growth factor receptor 2 status (OR = 5.32, 95% CI: 2.32-12.22) as significant predictors. Multivariate analysis confirmed lymph node metastasis (OR = 8.81, 95% CI: 3.68-21.07) and ER status (OR = 0.39, 95% CI: 0.16-0.94) as independent predictors. The nomogram model demonstrated an Area Under the Curve of 0.77 (95% CI: 0.68-0.85). The optimal cutoff value, derived from confusion matrix analysis, was 0.572, confirming the model's clinical utility.</p><p><strong>Conclusion: </strong>The AIUBS-based predictive model for postoperative recurrence and metastasis in breast cancer demonstrates high predictive accuracy and clinical utility, providing valuable support for personalized treatment and follow-up decisions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"4038-4053"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endorectal ultrasound with elastography for differentiating benign and malignant rectal tumors: a systematic review and meta-analysis.","authors":"Qinyi Qian, Xinxian Gu, Bo Shi, Chen Shen, Yinkai Xu, Wen Gu","doi":"10.62347/BJMS2565","DOIUrl":"10.62347/BJMS2565","url":null,"abstract":"<p><strong>Background: </strong>Timely and precise diagnosis of rectal tumors is pivotal for improving patient outcomes. Despite advances in imaging technologies, differentiating benign adenomas from early-stage rectal cancer remains a significant challenge. The aim of this study was to assess the effectiveness of endorectal ultrasound (ERUS) elastography in differentiating rectal adenomas from cancer.</p><p><strong>Methods: </strong>In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search of the PubMed, Embase, and Cochrane databases was performed to identify studies that used ERUS elastography to assess rectal adenomas and cancer. A random effects model was employed to pool the sensitivity, specificity, and diagnostic odds ratio (DOR) for ERUS elastography in the diagnosis of rectal tumors.</p><p><strong>Results: </strong>Ten studies encompassing a total of 722 patients with rectal tumors were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and DOR of ERUS elastography for distinguishing benign from malignant rectal tumors were 93% (95% confidence intervals (CI), 88%-96%), 86% (95% CI, 78%-92%), 6.71 (95% CI, 4.14-10.86), 0.08 (95% CI, 0.05-0.14), and 84 (95% CI, 38-186), respectively. The summary receiver operating characteristic (SROC) curve demonstrated an area under the curve (AUC) of 0.95 (95% CI, 0.93-0.97).</p><p><strong>Conclusion: </strong>ERUS elastography greatly enhances diagnostic precision by distinguishing rectal adenomas from cancer, providing an effective approach to differentiate benign from malignant rectal lesions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3830-3841"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}