American journal of translational research最新文献

{"title":"Insulin plus metformin for gestational diabetes mellitus: impacts on blood glucose, coagulation function, and pregnancy outcomes.","authors":"Yunping Wang, Nianling Yao, Lu Bai","doi":"10.62347/XVKR4141","DOIUrl":"10.62347/XVKR4141","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study focused on the impacts of insulin plus metformin (MET) on blood glucose (BG), coagulation function, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>The subjects were 129 GDM patients visiting The First Affiliated Hospital of Air Force Medical University, including 60 patients receiving insulin aspart (IA; control group) and 69 cases given MET+insulin aspart (observation group). General information and treatment outcomes were compared. Pre- and post-treatment BG (fasting plasma glucose [FPG], 2-hour postprandial plasma glucose [2hPG], glycosylated hemoglobin [HbA1c]), islet function (fasting insulin [FINS], Homeostasis Model Assessment-Insulin Resistance Index (HOMA-IR), HOMA-Beta Cell Function Index [HOMA-β]), coagulation function (activated partial thromboplastin time [APTT], prothrombin time [PT], thrombin time [TT]), adverse drug reactions, pregnancy outcomes, and fetal and neonatal conditions were compared between the two groups. Efficacy determinants were analyzed using univariate and multivariate methods.</p><p><strong>Results: </strong>Compared to controls, MET+IA-treated patients showed superior curative effects, lower post-treatment BG indexes, FINS, and HOMA-IR, higher HOMA-β and various coagulation function parameters, as well as reduced rates of overall adverse pregnancy outcomes, total neonatal adverse events, and macrosomia. The groups were comparable in the adverse drug reaction rate. An abortion history increased the risk of ineffective treatment.</p><p><strong>Conclusion: </strong>Insulin+MET benefits BG control, coagulation function, and pregnancy outcomes in GDM patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7025-7033"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannitol plus pilocarpine for primary acute angle-closure glaucoma: efficacy and safety analysis.","authors":"Shengmei Huang, Shiyi Tang, Wuyi Lu","doi":"10.62347/WXLV4056","DOIUrl":"10.62347/WXLV4056","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively analyze the efficacy and safety of mannitol (MAN) combined with pilocarpine (PC) in patients with primary acute angle-closure glaucoma (PAACG).</p><p><strong>Methods: </strong>A total of 103 PAACG patients were retrospectively enrolled and assigned to either the control group (PC alone) or the research group (MAN + PC). Treatment response, safety profiles, intraocular pressure (IOP), visual acuity (VA), hemodynamic parameters (end diastolic velocity [EDV], peak systolic velocity [PSV], and resistance index [RI]), anxiety/depression, and quality of life (Short-Form 36-Item Health Survey [SF-36]) were compared between the two groups. Furthermore, factors potentially associated with therapeutic efficacy and safety were analyzed.</p><p><strong>Results: </strong>The overall response rate was significantly higher in the research group than in the control group, whereas the incidence of adverse events were comparable between the two groups. After treatment, patients in the research group showed markedly lower IOP, PSV RI, and anxiety and depression scores, as well as significantly higher VA, EDV, and SF-36 scores, compared with the control group. However, none of these variables were independently associated with treatment efficacy or safety.</p><p><strong>Conclusion: </strong>MAN combined with PC is an effective and safe therapeutic strategy for PAACG patients. This combination therapy can improve patients' quality of life, reduce IOP, enhance VA, and improve central retinal artery hemodynamics.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6691-6699"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total parathyroidectomy with autotransplantation vs. subtotal parathyroidectomy for secondary hyperparathyroidism: lower recurrence rates but comparable cardiovascular outcomes.","authors":"Chenjun Guo, Jianjun Wang, Li Li","doi":"10.62347/FFOR6223","DOIUrl":"10.62347/FFOR6223","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the long-term efficacy and cardiovascular outcomes of total parathyroidectomy with autotransplantation (TPTX+AT) versus subtotal parathyroidectomy (SPTX) in maintenance hemodialysis (MHD) patients with refractory secondary hyperparathyroidism (SHPT).</p><p><strong>Methods: </strong>This retrospective cohort study enrolled MHD patients with SHPT who underwent parathyroidectomy between January 2020 and December 2022, with follow-up through December 2025. Patients were divided into TPTX+AT and SPTX groups. Serum intact parathyroid hormone (iPTH), corrected calcium, phosphorus, alkaline phosphatase, and 25-hydroxyvitamin D were measured preoperatively, on postoperative day 1, and at 3, 6, 12, and 36 months. Operative time, hospital stay, early complications, and long-term outcomes including SHPT recurrence, mortality, cardiovascular events, and permanent hypoparathyroidism were recorded.</p><p><strong>Results: </strong>Of 217 patients, 113 underwent TPTX+AT and 104 underwent SPTX. Operative time was longer with TPTX+AT (129.42 ± 34.74 min vs. 114.49 ± 29.71 min, <i>P</i> < 0.001). At 36 months, iPTH levels were significantly lower in the TPTX+AT group (209.74 ± 103.51 pg/mL vs. 464.53 ± 184.60 pg/mL, <i>P</i> < 0.001). SHPT recurrence was lower with TPTX+AT (14.16% vs. 36.54%, <i>P</i> < 0.001), while permanent hypoparathyroidism occurred only in the TPTX+AT group (5.31% vs. 0%, <i>P</i> = 0.049). All-cause mortality (13.27% vs. 13.46%), cardiovascular mortality (7.08% vs. 6.73%), and cardiovascular events (19.47% vs. 16.35%) were similar between groups (all <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>TPTX+AT achieves more durable biochemical control and lower SHPT recurrence but carries a definite risk of permanent hypoparathyroidism, with equivalent survival and cardiovascular outcomes, underscoring the need for individualized surgical selection.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7271-7284"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Xuebijing combined with ulinastatin in the treatment of sepsis complicated by acute lung injury: a meta-analysis.","authors":"Ting Zhang, Zhenfei Yuan","doi":"10.62347/BGCR6053","DOIUrl":"10.62347/BGCR6053","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of Xuebijing injection combined with ulinastatin in patients with sepsis complicated by acute lung injury.</p><p><strong>Methods: </strong>PubMed, Web of Science, the Cochrane Library, VIP Database, China National Knowledge Infrastructure and Wanfang Database were searched from inception to January 2026. Two reviewers independently screened studies, extracted data and assessed the risk of bias using the revised Cochrane Risk-of-Bias Tool for Randomized Trials, Version 2, for randomized controlled trials (RCTs) and the Risk Of Bias In Non-randomized Studies of Interventions tool for the retrospective study. Meta-analyses were performed using R version 4.2.0.</p><p><strong>Results: </strong>Thirteen studies involving 1,158 patients (670 in the combination therapy group and 488 in the control group) were included. Compared with control therapy, Xuebijing plus ulinastatin significantly reduced TNF-α, IL-6, HMGB-1, PCT and CRP levels; improved the oxygenation index; reduced the extravascular lung water index and Acute Physiology and Chronic Health Evaluation II score and shortened mechanical ventilation duration (all P < 0.05). The total effective rate (RD 0.179, 95% CI 0.101-0.257; NNT = 5.6; P < 0.001) and 28-day survival rate (RD 0.118, 95% CI 0.002-0.234; NNT = 8.5; P = 0.047) were significantly higher in the combination group, whereas the incidence of adverse events did not differ significantly between groups (RD -0.004, 95% CI -0.049-0.042; P = 0.881). Sensitivity analyses supported the robustness of the findings.</p><p><strong>Conclusion: </strong>Xuebijing combined with ulinastatin may reduce inflammation, improve lung function and disease severity, shorten mechanical ventilation duration and increase response and survival rates without increasing adverse events. Owing to heterogeneity in treatment regimens and inclusion criteria, these findings require validation in large-scale, multicenter RCTs.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7346-7364"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative anesthetic management characteristics associated with early postoperative voiding recovery and short-term urinary outcomes after HoLEP in elderly frail patients: a retrospective study.","authors":"Yuan Su, Yulin Wu, Chen Bao, Jian Dong, Chonglei Wang","doi":"10.62347/FWGW5106","DOIUrl":"10.62347/FWGW5106","url":null,"abstract":"<p><strong>Objective: </strong>To identify anesthetic factors associated with early voiding recovery after holmium laser enucleation of the prostate (HoLEP) in elderly frail patients, and to compare short-term urinary outcomes by recovery status.</p><p><strong>Methods: </strong>This single-center retrospective study included frail patients (aged ≥75 years, Clinical Frailty Scale score ≥5) who underwent HoLEP between January 2021 and December 2024. Patients were classified into good recovery, defined as spontaneous voiding after first catheter removal, and poor recovery defined as the inability to void or the need for re-catheterization. Baseline characteristics, perioperative variables, short-term outcomes were compared. Stepwise logistic regression was used to identify factors associated with early voiding recovery. Multivariable logistic regression was used to assess the association between recovery status and a composite adverse outcome including postoperative incontinence, urinary tract infection, hematuria or clot retention, and 30-day readmission.</p><p><strong>Results: </strong>Among 194 frail patients, 136 (70.1%) had poor early voiding recovery. In multivariable analysis, poor recovery was independently associated with higher postvoid residual volume (PVR, <i>P</i><0.001), intraoperative hypotension (OR 27.483, <i>P</i><0.001), greater intraoperative fluid administration (per 100-mL increase: OR 1.627, <i>P</i><0.001), and general anesthesia (OR 3.231, <i>P</i>=0.023). Patients with poor recovery had longer catheterization duration, longer hospital stay, and higher rates of incontinence, urinary tract infection, and readmission (all <i>P</i><0.05). Poor recovery was independently associated with the composite adverse outcome (adjusted OR 4.301, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>Early voiding status after catheter removal serves as a simple and practical clinical indicator to identify elderly frail HoLEP patients at risk of adverse short-term urinary outcomes.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6746-6758"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for catheter-related infections in neck tumor patients undergoing chemotherapy through peripherally inserted central catheters.","authors":"Ying Wu, Liandai Chen, Jinai He, Guohua Huang, Yutong Li","doi":"10.62347/NPWO2015","DOIUrl":"10.62347/NPWO2015","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the risk factors for catheter-related infections (CRI) in patients undergoing chemotherapy through tunneled peripherally inserted central catheters (PICCs) following neck tumor lymph node dissection. To provide evidence for clinical intervention strategies.</p><p><strong>Methods: </strong>A retrospective review was conducted on the medical records from 495 patients who underwent tunneled PICC placement for chemotherapy after neck tumor lymph node dissection. Patients were divided into a CRI group (n=55) and a non-CRI group (n=440). The incidence of CRI, infection type, and pathogen distribution were statistically analyzed. Multivariate logistic regression was employed to identify independent risk factors. A logistic regression-based predictive model was established and its performance was evaluated.</p><p><strong>Results: </strong>Among the 495 patients, the incidence of CRI was 11.11% (55/495), with exit-site infections being the predominant type (25 cases, 45.45%). A total of 11 pathogenic strains were isolated. Multivariate logistic regression analysis revealed that PICC indwelling duration >30 days, catheter displacement, concomitant diabetes mellitus, and white blood cell count ≤3.0×10⁹/L were independent risk factors for CRI (all P<0.05). The area under the curve (AUC) for the logistic regression model for predicting CRI efficacy was 0.896 [95% CI, 0.845, 0.947], with a sensitivity of 91.0% and a specificity of 79.0%. Calibration curves demonstrated good agreement with the ideal predictions.</p><p><strong>Conclusions: </strong>Patients undergoing chemotherapy through tunneled PICC after neck tumor lymph node dissection exhibit a relatively high incidence of CRI. Clinicians should implement targeted interventions for patients with prolonged catheterization, catheter displacement, diabetes mellitus, and leukopenia to reduce the incidence of CRI and improve patient outcome.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6580-6590"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of endometriosis by long non-coding RNA SRA through estrogen receptor: research progress.","authors":"Jin Li","doi":"10.62347/RJTS1592","DOIUrl":"10.62347/RJTS1592","url":null,"abstract":"<p><p>Endometriosis (EMS) is an estrogen-dependent chronic gynecologic condition that affects approximately 10%-15% of women of childbearing age. Long non-coding RNA SRA (lncRNA SRA) was the first identified non-coding RNA that possesses dual functions: it acts as an RNA scaffold and also encodes the SRAP protein. It participates in estrogen signaling by co-activating estrogen receptors. Recent studies have revealed a distinct expression pattern in ectopic lesions of EMS: lncRNA SRA and ERα are coordinately downregulated, whereas SRAP and ERβ are coordinately upregulated. This inverse correlation highlights a unique dual-function switching mechanism of the SRA/SRAP axis in the pathogenesis of EMS. In this review, we systematically summarize the conserved domain features of lncRNA SRA and its dual roles as an RNA scaffold and a protein-coding transcript. We then dissect the molecular mechanisms by which SRA/SRAP influences the ERα/ERβ balance, thereby modulating cell proliferation, apoptosis, and the inflammatory microenvironment in EMS. Based on current evidence, we propose a dual-function switching model: the EMS microenvironment drives alternative splicing of the SRA gene, shifting the output from lncRNA SRA toward SRAP protein. These two products selectively couple with ERα and ERβ, respectively, and jointly reshape estrogen receptor signaling in ectopic endometrial cells. Furthermore, we discuss the clinical translational potential of the lncRNA SRA/SRAP ratio as both a diagnostic biomarker and a therapeutic target, aiming to provide new insight for precision diagnosis and treatment of EMS.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6791-6806"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and a predictive nomogram for in-hospital deep vein thrombosis in elderly patients with multiple chronic conditions.","authors":"Ying Luo, Manyu Xu, Zhiying Xu, Hongmei Ji, Yalei Wu, Huan Shen, Caifeng Guan","doi":"10.62347/GFEV3120","DOIUrl":"10.62347/GFEV3120","url":null,"abstract":"<p><strong>Objective: </strong>To explore the independent influencing factors of deep venous thrombosis (DVT) in elderly patients with multiple chronic conditions (MCCs) and construct a predictive nomogram for this population.</p><p><strong>Methods: </strong>A total of 689 elderly patients with MCCs who were hospitalized from January 2023 to March 2025 were retrospectively enrolled in this study. Patients were categorized into a DVT group (73 cases) and a non-DVT group (616 cases). The overall cohort was randomly split into a training set (482 cases) and an internal validation set (207 cases) at a 7:3 ratio. An additional 360 patients admitted from April 2025 to April 2026 were enrolled as an external validation cohort. Receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) were used to evaluate the performance of the predictive model.</p><p><strong>Results: </strong>Age, MCCs number, polypharmacy, Padua score, limb muscle strength and DPR were identified as independent predicting factors for in-hospital DVT. The nomogram achieved an area under the curve (AUC) of 0.848. The AUC was 0.846 for the training set and 0.831 for the internal validation set, with good calibration. The external validation AUC was 0.807 with satisfactory calibration efficiency, and the DeLong test verified no significant difference in AUC values (P > 0.05). Furthermore, the model presented favorable clinical net benefits.</p><p><strong>Conclusion: </strong>The validated nomogram established based on six routinely accessible clinical indicators can effectively and reliably predict the risk of in-hospital DVT in elderly patients with MCCs.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7189-7200"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimetazidine combined with metoprolol improves therapeutic outcomes in patients with coronary heart disease complicated by heart failure.","authors":"Xiaoyan Liang, Feifei Wang, Zechen Bai","doi":"10.62347/WTNY7047","DOIUrl":"10.62347/WTNY7047","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic efficacy and influencing factors of metoprolol combined with trimetazidine in the treatment of heart failure secondary to coronary heart disease (CHD).</p><p><strong>Methods: </strong>A retrospective analysis was performed on 142 patients with CHD complicated by heart failure (HF) who were treated at the First Affiliated Hospital of Xinjiang Medical University from July 2023 to July 2025. Patients were allocated into a control group (trimetazidine monotherapy, n=70) and a joint group (metoprolol combined with trimetazidine, n=72). Clinical outcomes were compared between the two groups, including overall treatment efficacy, QT dispersion (QTd) before and after treatment, heart rate (HR), hemodynamic parameters [hematocrit (Hct), plasma fibrinogen (Fib), plasma specific viscosity], vascular endothelial function markers [calcitonin gene-related peptide (CGRP), plasma endothelin (ET), nitric oxide (NO)], cardiac function indicators [left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD)], and incidence of adverse reactions. Logistic multivariate regression analysis was performed to identify independent factors affecting therapeutic efficacy in CHD patients complicated by HF.</p><p><strong>Results: </strong>The total effective rate was significantly higher in the joint group than the control group (86.11% vs. 71.43%, P=0.032). After treatment, QTd, HR, ET, and hemodynamic parameters were significantly decreased in both groups compared with baseline, whereas CGRP, NO, and LVEF were significantly increased. Moreover, the improvement in the joint group was significantly superior to that in the control group (P<0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (13.89% vs. 12.86%, P=0.857). Multivariate logistic regression analysis identified treatment regimen, diabetes mellitus, and age as independent factors affecting therapeutic efficacy (P<0.05).</p><p><strong>Conclusion: </strong>Trimetazidine combined with metoprolol demonstrates superior efficacy without increasing adverse reactions in CHD patients complicated by HF. This combination therapy may improve hemodynamic status, endothelial function, and cardiac function, supporting its clinical application.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"7226-7235"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diuretic resistance during emergency treatment of acute heart failure: incidence and correlation with 30-day readmission.","authors":"Yan Liu, Lijie Ren, Junyu Wang","doi":"10.62347/UCRE7173","DOIUrl":"10.62347/UCRE7173","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the incidence of diuretic resistance (DR) during emergency treatment of acute heart failure (AHF) and its correlation with 30-day readmission.</p><p><strong>Methods: </strong>We retrospectively collected data from 198 AHF patients admitted to Beijing Chao-Yang Hospital, Capital Medical University between 2021 and 2025. Patients were allocated into a DR group and non-DR group according to the presence of diuretic resistance. Baseline characteristics, laboratory values, echocardiographic indices, and readmission rate were compared between the two groups. Logistic regression was performed to analyze the correlation between DR and short-term readmission rate. A nomogram was constructed to develop a clinical prediction model for readmission, and SHapley Additive exPlanations (SHAP) were used for model interpretation.</p><p><strong>Results: </strong>DR occurred in 48 patients (24.24%). The 30-day readmission rate was higher in the DR group than in the non-DR group (37.5% vs. 18.0%, <i>P</i><0.05). Multivariate logistic regression analysis identified DR (OR=4.69, 95% CI: 2.17-10.16, <i>P</i><0.001), New York Heart Association (NYHA) functional class (OR=5.05, 95% CI: 2.26-11.26, <i>P</i><0.001), and left ventricular ejection fraction (LVEF) (OR=0.90, 95% CI: 0.86-0.94, <i>P</i><0.001) as independent risk factors for readmission. The combined model demonstrated a significantly higher area under the receiver operating characteristic curve (ROC-AUC) compared to individual predictors (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The incidence of DR in AHF patients during emergency treatment is closely associated with an increased risk of 30-day readmission. Early identification and intervention for DR may improve short-term prognosis.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"18 8","pages":"6974-6987"},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}