Efficacy of integrating surgical interventions with chemoradiotherapy in managing stage IIIC cervical cancer.

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI:10.62347/GLOU3149
Xingshao Hu, Chenhong Ye, Jiaqiong Peng, Mingju Huang
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Abstract

Objective: This research is principally dedicated to exploring the therapeutic outcomes of integrating surgical intervention with chemoradiotherapy in patients diagnosed with stage IIIC cervical cancer (CC).

Methods: A cohort of 141 patients with stage IIIC CC admitted to Chongqing University Three Gorges Hospital were enrolled. Among them, 47 patients underwent radical chemoradiotherapy alone (control group), while 94 patients received surgical intervention in addition to radical chemoradiotherapy (research group). Treatment outcomes were comprehensively evaluated, including short-term therapeutic response, safety profiles, radiotherapy-related complications, long-term treatment efficacy - measured by progression-free survival (PFS) and overall survival (OS) and quality of life (QOL). Univariate and multivariate analyses were performed to identify independent predictors of long-term treatment outcomes.

Results: The research group exhibited significantly superior short-term efficacy compared to the control group. Additionally, the research group showed a notably lower rate of treatment-associated adverse events, but radiotherapy-induced complications occurred at a similar frequency as in the control group. Long-term outcomes, including PFS, OS, and QOL scores, were also significantly better in the research group. Both univariate and multivariate analyses identified body mass index (BMI) and treatment modality as independent prognostic factors for long-term outcomes in patients with stage IIIC CC.

Conclusions: The integration of surgical intervention with radical chemoradiotherapy yields superior therapeutic outcomes compared to chemoradiotherapy alone in the management of stage IIIC cervical cancer, highlighting its potential as a more effective treatment strategy.

手术联合放化疗治疗IIIC期宫颈癌的疗效观察。
目的:本研究主要探讨IIIC期宫颈癌(CC)患者手术联合放化疗的治疗效果。方法:选取重庆大学三峡医院IIIC期CC患者141例为研究对象。其中单纯根治性放化疗47例(对照组),在根治性放化疗的基础上进行手术干预94例(研究组)。综合评估治疗结果,包括短期治疗反应、安全性、放疗相关并发症、长期治疗疗效(以无进展生存期(PFS)、总生存期(OS)和生活质量(QOL)衡量)。进行单因素和多因素分析以确定长期治疗结果的独立预测因素。结果:研究组近期疗效明显优于对照组。此外,研究组的治疗相关不良事件发生率明显较低,但放疗引起的并发症发生率与对照组相似。长期预后,包括PFS、OS和QOL评分,研究组也明显更好。单因素和多因素分析均表明,体重指数(BMI)和治疗方式是影响IIIC期宫颈癌患者长期预后的独立因素。结论:在IIIC期宫颈癌的治疗中,手术干预联合根治性放化疗的治疗效果优于单纯放化疗,这凸显了其作为一种更有效的治疗策略的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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552
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