Association of heparin-binding protein with risk of in-hospital heart failure in patients with acute coronary syndrome.

Objectives: To investigate the relationship between heparin-binding protein (HBP) levels and the risk of involving heart failure occurring during hospitalization in patients with acute coronary syndrome (ACS).

Methods: This single-center retrospective study included 274 patients with ACS hospitalized at the Third Affiliated Hospital of Zunyi Medical University between June and December 2023. The primary outcome was the occurrence of in-hospital heart failure (HF). Multivariable logistic regression and restricted cubic spline (RCS) models were used to assess the relationship between HBP and HF. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of HBP for HF events.

Results: During hospitalization, 56 patients (20.4%) developed HF. Patients with HF patients had higher HBP levels (p < 0.01). HBP was significantly associated with in-hospital HF risk (Model 3 OR = 4.232, P < 0.001). ROC analysis showed that HBP had a predictive value for HF events (AUC = 0.696, sensitivity = 55.36, specificity = 76.61, P < 0.001). The RCS model indicated a nonlinear dose-response relationship between HBP levels and in-hospital HF (P for nonlinearity = 0.007).

Conclusion: HBP levels are associated with an increased risk of in-hospital HF in patients with ACS and serve as a superior predictor compared to traditional parameters and inflammatory markers.