Therapeutic effects of transverse tibial bone transport in lower limb thromboangiitis obliterans.

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI:10.62347/HAAJ5979
Minyou Hong, Qi Jin
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引用次数: 0

Abstract

Objective: To investigate the treatment efficacy of transverse tibial bone transport (TTT) technique in patients with lower-limb thromboangiitis obliterans (LLTAO).

Methods: A total of 119 patients diagnosed with LLTAO were selected for this retrospective study. Among them, 55 patients treated with conventional methods were assigned into the control group, while the other 64 patients treated with TTT technique were classified into the observation group. Systematic comparative evaluations were conducted between the two patient cohorts, analyzing four key domains: clinical recovery, hemorheological profile alterations, quality of life metrics, and treatment efficacy. Furthermore, we performed an exploratory analysis to identify determinants affecting therapeutic outcome.

Results: The observation group showed significantly better outcomes than the control group in terms of functional recovery, hemorheological improvement, quality of life scores, and overall treatment effectiveness following the intervention. Univariate and multivariate analyses further demonstrated that age, pretreatment HBV, and treatment approach were all independent factors influencing treatment efficacy in these patients.

Conclusion: The TTT technique exhibits superior therapeutic benefits for LLTAO patients over conventional intervention, establishing it as an effective treatment for this challenging condition.

胫骨横骨转运治疗下肢血栓闭塞性脉管炎的疗效。
目的:探讨胫横骨转运(TTT)技术治疗下肢血栓闭塞性脉管炎的疗效。方法:选取119例确诊为LLTAO的患者进行回顾性研究。其中55例采用常规方法治疗为对照组,64例采用TTT技术治疗为观察组。在两组患者之间进行了系统的比较评估,分析了四个关键领域:临床恢复、血液流变学改变、生活质量指标和治疗效果。此外,我们进行了探索性分析,以确定影响治疗结果的决定因素。结果:观察组干预后在功能恢复、血液流变学改善、生活质量评分、整体治疗效果等方面均明显优于对照组。单因素和多因素分析进一步表明,年龄、HBV预处理、治疗方式均是影响患者治疗效果的独立因素。结论:TTT技术对LLTAO患者的治疗效果优于常规干预,是治疗这种具有挑战性疾病的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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