Jiaxian Zhou, Yinan Yang, Shuyi Li, Ningwen Mao, Xi Chen, Dan Wang, Yanxia Zhang, Xiaoru Shi, Jianmiao Li, Xin Gao, Shengxin Tao, Xuhong Pu, Jie Lu, Xiaobin Hu
{"title":"Patterns of social participation among older adults and their association with self-rated health: the mediating role of activities of daily living.","authors":"Jiaxian Zhou, Yinan Yang, Shuyi Li, Ningwen Mao, Xi Chen, Dan Wang, Yanxia Zhang, Xiaoru Shi, Jianmiao Li, Xin Gao, Shengxin Tao, Xuhong Pu, Jie Lu, Xiaobin Hu","doi":"10.1007/s40520-025-03131-3","DOIUrl":"10.1007/s40520-025-03131-3","url":null,"abstract":"<p><strong>Background: </strong>The aging population poses challenges in various areas, particularly regarding the health of older adults, which is becoming a worldwide issue due to decreasing physical abilities. Social participation improves both mental and physical well-being, making it an important approach for promoting active aging. This research examined the patterns of social participation among the older adults and how these patterns relate to their Activity of Daily Living and their Self-rated Health.</p><p><strong>Methods: </strong>Utilizing data from the 7th National Health Service Survey in Gansu, a potential category analysis was performed to examine the social participation patterns of older adults. To investigate how these patterns influence Self-rated Health and the Activity of Daily Living, mediation effect analysis was carried out, incorporating classical triple regression, structural equation modeling, and Bayesian structural equation modeling.</p><p><strong>Results: </strong>In Gansu Province, the social participation patterns among older adults are categorized as Diverse Participation(9.85%), Agricultural-centered Participation (29.02%), and Low Participation (61.13%). Those engaged in diverse and agricultural participation exhibit better Activities of Daily Living and Self-rated Health compared to those with low participation. Using the Low Participation group as reference, both Diverse Participation (β = 0.038, 95% CI = 0.028-0.047) and Agricultural-centered Participation (β = 0.042, 95% CI = 0.030-0.055) showed that the association between social participation and Self-rated Health was achieved partly through Activities of Daily Living this mediators, accounting for 34.23% (Diverse Participation) and 40.00% (Agricultural-centered Participation) of the total effects respectively.</p><p><strong>Conclusion: </strong>Activities of Daily Living mediates the relationship between social participation and Self-rated Health. Attention should be paid to the Activities of Daily Living of older adults, with particular attention to those living alone and those who are chronically ill, and to social resources to enhance the social participation of older persons.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"221"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Fantin, Serena Nicolussi Paolaz, Anna Giani, Elisa Mattachini, Elena Zoico, Mauro Zamboni
{"title":"Central and peripheral arterial stiffness and sarcopenia in hospitalized older adults.","authors":"Francesco Fantin, Serena Nicolussi Paolaz, Anna Giani, Elisa Mattachini, Elena Zoico, Mauro Zamboni","doi":"10.1007/s40520-025-03122-4","DOIUrl":"10.1007/s40520-025-03122-4","url":null,"abstract":"<p><strong>Objective: </strong>Both sarcopenia and arterial wall stiffening are frequent findings among hospitalized older adults, and further insight should be gained to explore their pathophysiological mechanisms and possible correlations.</p><p><strong>Methods: </strong>90 hospitalized geriatric patients (mean age 83.94 ± 6.6 years, 38.89% female, 36.7% sarcopenic) have been enrolled, and underwent clinical, comorbidity and biochemical assessment. Sarcopenia was investigated following the diagnostic algorithm according to European guidelines assessing muscular strength, using a portable dynamometer, and muscle mass by bio-impedance analysis (BIA); carotid-femoral pulse wave velocity (cfPWV), carotid-radial PWV (crPWV), femoral-pedal PWV (fpPWV) and cardio-ankle vascular index (CAVI) were obtained for each.</p><p><strong>Results: </strong>Sarcopenic patients (n = 33) were older (p < 0.01) than subjects without sarcopenia (n = 57). Sarcopenic patients presented higher CAVI (12.67 ± 3.12 vs. 10.91 ± 1.4, p < 0.01) and fpPWV, but not cfPWV and crPWV. In backward analysis muscle strength and comorbidity index resulted good indipendent variables of fpPWV (R<sup>2</sup> 0.11), muscle strength, comorbidity index and sex could predict CAVI (R<sup>2</sup> 0.22). When examining sarcopenia diagnoses determinants, in a logistic binary regression model and considering several possible covariates, fpPWV resulted a significant indipendent variable of sarcopenia along with age and sex.</p><p><strong>Conclusion: </strong>increased indexes of arterial stiffness are shown in sarcopenic hospitalized older adults as compared to hospitalized patients without sarcopenia; peripheral arterial segments of the lower limb appeared to be more involved in the stiffening process, as compared to central segments.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"223"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clemens Roitzsch, Franziska Beyer, Klaus-Dieter Schaser, Roman Riedel, Marcel Mäder, Anne Postler
{"title":"Unveiling the hidden risks: 90-day mortality and complications in older adults with proximal femur fractures.","authors":"Clemens Roitzsch, Franziska Beyer, Klaus-Dieter Schaser, Roman Riedel, Marcel Mäder, Anne Postler","doi":"10.1007/s40520-025-03134-0","DOIUrl":"10.1007/s40520-025-03134-0","url":null,"abstract":"<p><strong>Background: </strong>Proximal femur fractures (PFF) are the most common fracture type worldwide, particularly in geriatric patients. Despite advancement in treatment, mortality rates in this patient group remain high.</p><p><strong>Aims: </strong>The aim of this study was to analyze potential factors, influencing the 90-day mortality rate and complication rate after PFF surgery in a tertiary care hospital.</p><p><strong>Methods: </strong>Between 2019 and 2022, all patients aged 65 and older with PFF and a positive screening as a geriatric patient were included in this prospective, single-center study. Data collected included gender, age, BMI, fracture type, type and timing of surgery, comorbidities, medication, mobilization and blood loss as well as complications and 90-day mortality.</p><p><strong>Results: </strong>Out of 1217 analyzed geriatric patients, 61% underwent surgery within 24 h. The complication rate was 21.7% with 3% surgical and 20.2% non-surgical complications. Median age was 87 years and 68% were female, while mean Charlson Comorbidity Index was 2.6 points and 84% had ASA 3 or 4. 240 patients (19.7%) died within 90 days after surgery. Higher mortality rates were associated with male gender (OR 1.341), higher age (OR 1.093), lower BMI (OR 0.946), higher Charlson Comorbidity Index (OR 1.202), non-surgical complications (OR 2.541) and if mobilization was impossible (OR 10.013). A delay of surgery beyond 24 h after admission was associated with the development of wound infections (p = 0.022) and internal medicine-related complications (p = 0.002).</p><p><strong>Discussion: </strong>While no correlation was found between surgery timing and 90 days mortality, delays in surgery were associated with adverse effects, including wound infections and internal medicine complications.</p><p><strong>Conclusion: </strong>The mortality rates of patients suffering from PFF maintain high and are mainly influenced by non-modifiable patient-related factors.</p><p><strong>Clinical trials registration: </strong>German Registry for Clinical Trials, ID: DRKS00034048, date of registration: 10.02.2025. Retrospectively registered.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"220"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simone Filomia, Gianluigi Saponara, Marco Giuseppe Del Buono, Alessia d'Aiello, Mattia Brecciaroli, Daniela Pedicino, Rocco Montone, Gaetano Pinnacchio, Lorenzo Genuardi, Jacopo Lenkowicz, Pierluigi Rogati, Carlo Trani, Giovanna Liuzzo, Francesco Burzotta, Tommaso Sanna
{"title":"Admission reasons, procedures, and mortality of elderly patients in CICU: the SAGE-CICU study (study on acute gaps in the elderly - cardiac intensive care unit).","authors":"Simone Filomia, Gianluigi Saponara, Marco Giuseppe Del Buono, Alessia d'Aiello, Mattia Brecciaroli, Daniela Pedicino, Rocco Montone, Gaetano Pinnacchio, Lorenzo Genuardi, Jacopo Lenkowicz, Pierluigi Rogati, Carlo Trani, Giovanna Liuzzo, Francesco Burzotta, Tommaso Sanna","doi":"10.1007/s40520-025-03108-2","DOIUrl":"10.1007/s40520-025-03108-2","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"224"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaodan Guo, Minmin Wu, Huazhen Xiao, Jialin Liu, Xiaoqian Zhu, Shuang Jin, Yuhong Liu, Yuanfan Zhu, Xin Lin, Yan Mu
{"title":"Prognostic impact of multi-domain approaches and the Tilburg frailty indicator in elderly patients with heart failure.","authors":"Xiaodan Guo, Minmin Wu, Huazhen Xiao, Jialin Liu, Xiaoqian Zhu, Shuang Jin, Yuhong Liu, Yuanfan Zhu, Xin Lin, Yan Mu","doi":"10.1007/s40520-025-03121-5","DOIUrl":"10.1007/s40520-025-03121-5","url":null,"abstract":"<p><strong>Backgrounds: </strong>The optimal multidimensional frailty assessment approach in heart failure (HF) remains uncertain. This study aimed to compare the prognostic value of a multi-domain approach versus the Tilburg Frailty Indicator (TFI) in elderly HF patients.</p><p><strong>Methods: </strong>This prospective single-center cohort study consecutively enrolled 461 elderly HF patients at Fuzhou University Affiliated Provincial Hospital, China. Frailty was assessed using both the TFI and a multi-domain approach. The primary outcome was the composite of heart failure hospitalization or all-cause death within six months. Clinical outcomes were analyzed using Kaplan-Meier and Cox proportional hazards regression models, with predictive performance compared by receiver operating characteristic curves.</p><p><strong>Results: </strong>Among 461 participants, physical, psychological, and social frailty prevalence rates were 41.0%, 59.9%, and 56.8%, respectively. Multidimensional frailty, assessed by the TFI, was present in 77.4% of the cohort. The risk of composite outcome increased significantly with the number of frailty domains [2 domains: adjusted HR = 1.74 (95% CI: 1.08-2.79); 3 domains: HR = 2.07 (1.28-3.35)]. TFI-based analysis yielded consistent results. Notably, the predictive accuracy of frailty domains (area under the curve (AUC) = 0.63, 95% CI: 0.58-0.69) did not significantly differ from that of the TFI (AUC = 0.64, 95% CI: 0.59-0.70; P = 0.713), indicating comparable discriminative ability.</p><p><strong>Conclusions: </strong>In elderly HF patients, both the multi-domain frailty assessment and the TFI demonstrated comparable predictive value for heart failure hospitalization or all-cause death within six months.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"225"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hélio José Coelho-Júnior, Alejandro Álvarez-Bustos, Andrea Russo, Leocadio Rodriguez-Mañas, Francesco Landi, Emanuele Marzetti
{"title":"Operationalizing Short Physical Performance Battery (SPPB) with muscle strength and power: predicting adverse events in older adults from the ilsirente study.","authors":"Hélio José Coelho-Júnior, Alejandro Álvarez-Bustos, Andrea Russo, Leocadio Rodriguez-Mañas, Francesco Landi, Emanuele Marzetti","doi":"10.1007/s40520-025-03120-6","DOIUrl":"10.1007/s40520-025-03120-6","url":null,"abstract":"<p><strong>Background and aims: </strong>The present study examined associations between Short Physical Performance Battery (SPPB) indexes operationalized according to lower limb muscle strength and power and the incidence of adverse events in older community-dwellers.</p><p><strong>Methods: </strong>This was a prospective cohort study of octogenarians who lived in the mountain community of the Sirente geographic area in Central Italy. Participants completed the SPPB under standardized conditions. Lower limb muscle power was estimated according to results from the 5-time sit-to-stand (5STS) test using validated equations. Then, four SPPB indexes were created by replacing 5STS test results with muscle power measures. Outcomes were assessed 24 months after baseline and included falls, fractures, and death.</p><p><strong>Results: </strong>Data of 255 older adults (mean age: 85.8 ± 4.8 years; women: 67.0%) were examined. Binary regression analysis indicated that conventional SPPB was significantly associated with the incidence of falls (Odds ratio [OR] = 0.841, [95% confidence interval [CI]] = 0.758, 0.934), fractures (OR = 0.837, 95%CI = 0.702, 0.998), and death (hazard ratio = 0.961, 95%CI = 0.934, 0.999). However, no significant results were found when SPPB was operationalized according to muscle power parameters. Area under the curve (AUC) results indicated that SPPB indexes had lower accuracy for distinguishing participants at higher risk of negative events.</p><p><strong>Discussion and conclusions: </strong>Results of the present study indicate that conventional SPPB, but not SPPB indexes operationalized according to lower limb muscle power, was significantly associated with the incidence of negative events in older adults. However, SPPB indexes were not good to identify older adults at higher risk of experiencing negative events.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"222"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations of cadmium exposure within heavy metal combinations with osteoporosis risk: an analysis of NHANES data (2013-2014 and 2017-2018).","authors":"Zhongshan Li, Rui Jiang, Qi Qu, Shuanglin Mou, Zheng Zhang, Wensheng Zhu","doi":"10.1007/s40520-025-03047-y","DOIUrl":"10.1007/s40520-025-03047-y","url":null,"abstract":"<p><strong>Background: </strong>Environmental pollution is widely acknowledged as a critical contributor to osteoporosis. Previous studies confirmed that heavy metal exposure is closely associated with decreased bone mineral density.</p><p><strong>Objective: </strong>This study aimed to evaluate the relationship between cadmium (Cd) and the incidence of osteoporosis, and to explore the mediating role of inflammatory response and oxidative stress in the relationship.</p><p><strong>Methods: </strong>We examined the relationship between blood Cd levels and osteoporosis risk using data from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013-2014 and 2017-2018, employing three statistical methods to evaluate these associations. Mediation analysis was conducted to investigate how inflammation and oxidative stress mediate Cd exposure-induced osteoporosis.</p><p><strong>Results: </strong>Among the 1290 individuals included in this study, 79 (6.12%) were diagnosed with osteoporosis. Our logistic regression analysis revealed a positive correlation between log10 Cd concentration and osteoporosis risk. Furthermore, heavy metal combinations showed a positive correlation with osteoporosis risk, with Cd identified as the primary factor in the Weighted Quantile Sum (WQS) and Bayesian Kernel Machine Regression (BKMR) models. Additionally, inflammation and oxidative stress acted as mediators in the correlation between Cd exposure and osteoporosis risk, accounting for 10.10% (OR: 0.002, 0.3, P = 0.042) and 4.06% (OR: 0.003, 0.11, P = 0.018) of the effect, respectively.</p><p><strong>Conclusion: </strong>Our findings suggest that excessive Cd exposure increases osteoporosis risk, with inflammation and oxidative stress as key mediators. These results highlight the need for targeted strategies to reduce Cd exposure and protect bone health.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"219"},"PeriodicalIF":3.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and validation of a nomogram model for predicting MDRO infections in elderly ICU patients with pulmonary infections.","authors":"Bo Wang, Suming Zhang, Lei Meng, Jingjing Feng","doi":"10.1007/s40520-025-03136-y","DOIUrl":"10.1007/s40520-025-03136-y","url":null,"abstract":"<p><strong>Background: </strong>MDRO infections are increasingly problematic in ICUs, especially among elderly patients with lung infections, but knowledge about these infections in this group is limited. This study aimed to assess the status and risk factors of MDRO infections in elderly ICU patients and develop a risk prediction model to aid clinical decisions.</p><p><strong>Methods: </strong>Using a retrospective cohort study, a total of 494 elderly patients with lung infections admitted to the ICU from January 2017 to December 2022 were selected, and the patients were divided into the MDRO group (259) and the non-MDRO group (235) based on whether or not the patients developed MDRO infections. Lasso and multifactorial logistic regression were applied to analyze the independent risk factors for multidrug-resistant bacterial infections in elderly patients with pulmonary infections, and to construct a nomogram model of the risk of MDRO infections. The differentiation, consistency and clinical benefit of the model were evaluated by receiver operating characteristic curve(ROC), calibration curves and decision curve analysis, respectively, and the stability of the model was verified by Bootstrap method.</p><p><strong>Results: </strong>Duration of hospitalization before MDRO diagnosis, chronic obstructive pulmonary disease, personal history of cerebrovascular disease, tracheotomy and prior carbapenem exposure were found to be independent risk factors for multidrug-resistant bacterial infections in elderly patients with pulmonary infections in the intensive care unit (all p < 0.05). The nomogram model, constructed based on the results of logistic regression analysis, exhibited an area under the ROC curve of 0.748 with a 95% confidence interval of 0.705-0.790. The Hosmer-Lemeshow test indicated that the model predicted a good fit (p = 0.75), and the DCA curve suggested that the model had a good clinical utility.</p><p><strong>Conclusion: </strong>Risk prediction model is effective in predicting the risk of MDRO infection in the ICU elderly pulmonary infection population and can be used to assess risk and inform preventive treatment and nursing interventions.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"218"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Lu, Frank Mastaglia, Andrew Chi Pang Tai, Max K Bulsara, William G Blakeney, Charles A Inderjeeth, Minghao Zheng, Jun Yuan
{"title":"Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank.","authors":"Jun Lu, Frank Mastaglia, Andrew Chi Pang Tai, Max K Bulsara, William G Blakeney, Charles A Inderjeeth, Minghao Zheng, Jun Yuan","doi":"10.1007/s40520-025-03100-w","DOIUrl":"10.1007/s40520-025-03100-w","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis and dementia are two common disorders mainly affecting ageing population, and heel estimated bone mineral density (eBMD) measured by quantitative ultrasound (QUS) has been demonstrated to be a reliable and non-invasive method for assessing skeletal health. The aim of this study is to determine the association between eBMD and incident dementia in older adults.</p><p><strong>Methods: </strong>This retrospective cohort study employs UK Biobank data of 131,030 adults aged ≥ 60 years without dementia at baseline. Cox proportional-hazards models were used to investigate the association between eBMD and incident dementia, with the C-index evaluating the discriminative potential of eBMD.</p><p><strong>Results: </strong>Among participants (52.1% women, median [IQR] age was 64 [62-66] years), there were 4,572 cases (3.5%) of incident dementia. Minimal model showed that participants with low eBMD (< 0.467 g/cm<sup>2</sup>) had a 14% increase in the rate of dementia incidence (HR 1.14, 95% CI 1.06-1.23; P <.001), and each standard deviation (SD) decrease in eBMD was associated with a 49% increase in dementia risk (HR 1.49, 95% CI 1.19-1.86; P <.001). Such association remained significant after further adjustment for potential confounders. Stratified analyses revealed that lower eBMD increased dementia risk in male participants (HR 1.17, 95% CI 1.06-1.31; P =.003) and in participants with neutral (HR 1.18, 95% CI 1.05-1.33; P =.007) or low genetic risk (HR 1.36, 95% CI 1.01-1.83; P =.04). Sensitivity analyses showed similar results. However, discriminative analyses showed minimal improvement after adding eBMD to dementia prediction models.</p><p><strong>Conclusion: </strong>Lower heel eBMD is independently associated with increased dementia risk among older adults.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"217"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Menéndez-Granda, Nadine Schmidt, Michael Orth, Sebastian Horn, Matthias Kliegel, Jessica Peter
{"title":"Incentives and practice improve prospective memory performance in older adults.","authors":"Marta Menéndez-Granda, Nadine Schmidt, Michael Orth, Sebastian Horn, Matthias Kliegel, Jessica Peter","doi":"10.1007/s40520-025-03127-z","DOIUrl":"10.1007/s40520-025-03127-z","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"212"},"PeriodicalIF":3.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}