Aging Clinical and Experimental Research最新文献

{"title":"Mediterranean diet and spirituality/religion: eating with meaning","authors":"Ligia J. Dominguez,&nbsp;Nicola Veronese,&nbsp;Francesco Saverio Ragusa,&nbsp;Valentina Petralia,&nbsp;Stefano Ciriminna,&nbsp;Giovanna Di Bella,&nbsp;Piero Schirò,&nbsp;Shaun Sabico,&nbsp;Nasser M. Al-Daghri,&nbsp;Mario Barbagallo","doi":"10.1007/s40520-024-02873-w","DOIUrl":"10.1007/s40520-024-02873-w","url":null,"abstract":"<div><p>The interest in the Mediterranean diet has grown considerably due to its potential health benefits on the prevention of diverse age-related chronic diseases and its association with longevity. This dietary pattern, considered among the healthiest in the world, is not simply a combination of healthy foods but goes further in its historical and cultural roots. Mediterranean diet is not intrinsically tied to any specific religion or spiritual system, but its cultural and geographical context has influenced the dietary practices of its inhabitants, encompassing the history of Western civilization and of the three Monotheistic religions Christianity, Judaism, and Islam. These religions may have some impact on dietary choices due to religious customs and practices. In 2010 the Mediterranean diet was inscribed on the UNESCO’s Representative List of Intangible Cultural Heritage of Humanity, highlighting it as a social and cultural expression of the different food cultures of the Mediterranean region and indicating that the importance of this dietary and lifestyle pattern lies not only in its specific foods and nutrients, but in the way in which its characteristic foods are produced, cooked, and eaten. In this narrative review we will discuss the possible connections between the main religions originated in the Mediterranean basin and their influence on the composition of the Mediterranean diet, and the links between spirituality/religion and this dietary pattern. This traditional model can represent a form of conscious healthy eating and lifestyle in contrast to the unhealthy Western lifestyle and ultra-processed food consumption widespread throughout the world.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02873-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychology of sexuality in older adults: bridging gaps in literature and future directions in research","authors":"Federica Taccini,&nbsp;Margherita Rossi,&nbsp;Stefania Mannarini,&nbsp;Marina De Rui,&nbsp;Chiara Ceolin,&nbsp;Biancarosa Volpe,&nbsp;Michela Sarlo,&nbsp;Daniela Mapelli,&nbsp;Giuseppe Sergi,&nbsp;Maria Devita","doi":"10.1007/s40520-024-02885-6","DOIUrl":"10.1007/s40520-024-02885-6","url":null,"abstract":"<div><p>Sexuality is a fundamental part of human existence and it encompasses thoughts, desires, behaviors, relationships, as well as neuropsychological and physiological components. However, sexuality in older adults is under-researched from the neuropsychological and psychophysiological perspectives and is often neglected by healthcare providers in the clinical practice. This article aims to explore the state of the art on the neuropsychology and psychophysiology of older adults’ sexuality, proposing future research directions and emphasizing its significance. By summarizing current knowledge on the sexuality of younger individuals, it was possible to lay the groundwork for formulating research questions about older adults’ sexuality. The implications proposed in this article will potentially impact both the scientific and also the clinical field. In fact, gaining insights on the neuropsychological and psychophysiological aspects of sexuality in healthy older adults can also shed light into those with neurocognitive disorders.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02885-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysmagnesemia with acute kidney injury among older adults: clinical characteristics and prognostic importance","authors":"Qinglin Li,&nbsp;Xin Hu,&nbsp;Guanggang Li,&nbsp;Dawei Li,&nbsp;Qiangguo Ao,&nbsp;Feihu Zhou","doi":"10.1007/s40520-024-02872-x","DOIUrl":"10.1007/s40520-024-02872-x","url":null,"abstract":"<div><h3>Purpose</h3><p>The relationship between dysmagnesemia and all-cause mortality probability in individuals with acute kidney injury (AKI) have not been investigated. In this study, we evaluated the correlation of varying magnesium levels with mortality in older adults undergoing AKI.</p><h3>Patients and methods</h3><p>Older adults receiving treatment at the Chinese PLA General Hospital between 2007 and 2018 were retrospectively recruited. All-cause mortality was evaluated at four preset magnesium concentrations: &lt;0.8, 0.8–0.9, 0.9–1.0, and ≥ 1.0 mmol/L. Using multivariable-adjusted Cox assessment, the all-cause mortality risk was approximated by setting the reference magnesium concentration at 0.8–0.9 mmol/L.</p><h3>Results</h3><p>Totally 744 participants were enrolled, whose median age was 88 years, with most of them being male (94.2%). Among them, 184 patients were assigned into the &lt; 0.8 mmol/L group, 156 into the 0.8–0.9 mmol/L group, 206 into the 0.9–1.0 mmol/L group, and 198 into the ≥ 1.0 mmol/L group. After 28 days, the mortality rates in the four strata were 26.6, 17.9, 17.5, and 37.4%, respectively. The corresponding mortalities after 90 days were 42.4, 23.7, 26.7, and 45.5%, respectively. Compared with patients who had magnesium levels of 0.8–0.9 mmol/L, those with magnesium levels &lt; 0.8 mmol/L (<i>P</i> = 0.048), and ≥ 1.0 mmol/L (<i>P</i> &lt; 0.001) exhibited higher 28-day mortalities. Significant correlations also showed that patients with magnesium levels &lt; 0.8 mmol/L (<i>P</i> = 0.017) and ≥ 1.0 mmol/L (<i>P</i> &lt; 0.001) were significantly related to the increased 90-day mortality.</p><h3>Conclusion</h3><p>Magnesium levels outside the interval of 0.8–1.0 mmol/L were related to the higher risks of 28- and 90-day mortalities among older adults with AKI.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02872-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity and risk of adverse outcomes in the Hertfordshire Cohort Study: does sex matter?","authors":"Leo D. Westbury,&nbsp;Roshan Rambukwella,&nbsp;Camille Pearse,&nbsp;Kate A. Ward,&nbsp;Cyrus Cooper,&nbsp;Elaine M. Dennison","doi":"10.1007/s40520-024-02874-9","DOIUrl":"10.1007/s40520-024-02874-9","url":null,"abstract":"<div><h3>Aims</h3><p>We examined whether admission risk increases at a certain threshold of number of systems medicated or whether any increase confers greater admission risk in either sex in a community-dwelling cohort of older persons in Hertfordshire. This study uses a longitudinal retrospective study design.</p><h3>Methods</h3><p>Data from 2997 men and women (aged 59–73 at baseline) were analyzed. Participants were followed up from baseline (1998–2004) until December 2018 using Hospital Episode Statistics and mortality data, reporting clinical outcomes using ICD-10 coding. Number of systems medicated in relation to mortality (all-cause, cancer-related, cardiovascular-related) and admission (any, neurological, cardiovascular, and respiratory) were examined using Cox regression.</p><h3>Results</h3><p>Apart from cancer-related mortality among women, more systems medicated predicted increased risk of all events among both sexes (<i>p</i> ≤ 0.001). For ‘any’, cardiovascular and respiratory admissions, there were increases in risk for each category of number of systems medicated. For example, compared to men with no systems medicated, those with 1, 2 and &gt; 2 systems medicated had hazard ratios (95% CI) for cardiovascular admissions of 1.82 (1.57,2.12), 2.39 (2.00,2.84) and 3.45 (2.84,4.20) respectively; estimates among women were 1.74 (1.44,2.11), 2.35 (1.92,2.88) and 3.40 (2.79,4.13).</p><h3>Conclusions</h3><p>Increases in numbers of systems medicated conferred greater risk of admission in both sexes. Interventions aimed at reducing the burden of chronic disease in mid-late adulthood are required.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02874-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the perceptions and experiences of older people on the use of digital technologies during the COVID-19 pandemic: a qualitative study","authors":"Lesley-Anne Tanhamira,&nbsp;Gurch Randhawa,&nbsp;David Hewson","doi":"10.1007/s40520-024-02878-5","DOIUrl":"10.1007/s40520-024-02878-5","url":null,"abstract":"<div><h3>Background</h3><p>Physical inactivity is an ongoing problem throughout the lifespan. For older people, inactivity has a negative impact on wellbeing, which worsened during the COVID-19 pandemic. Digital technologies can be employed to encourage uptake of social and physical activity through remotely delivered interventions to improve wellbeing, however, we need to understand older people’s perceptions and experiences of using digital technologies before implementing these interventions.</p><h3>Aims</h3><p>To explore the perceptions and experiences of older people on the use of digital technologies during the COVID-19 pandemic.</p><h3>Methods</h3><p>Qualitative semi-structured interviews were conducted with 16 community dwelling older people from Hertfordshire, United Kingdom who were all programme participants in a remotely delivered mind-body physical activity programme called Positive Movement. Interviews were conducted before programme participation. The audio recorded interviews were transcribed and analysed using thematic analysis.</p><h3>Results</h3><p>Four themes emerged from the data. The perceived impact of COVID-19 on social contact, perceived impact of COVID-19 on mental wellbeing, using digital platforms for health or exercise and using digital platforms for social contact.</p><h3>Discussion</h3><p>Participants reported reduced social contact due to COVID-19. Most participants reported using digital technologies for social inclusion rather than health reasons, and there were mixed views on the willingness to use digital technologies for physical activity.</p><h3>Conclusion</h3><p>Digital technologies offered a lifeline during COVID-19 to maintain social contact and their use was found acceptable by older people. Digital platforms such as Zoom can be further employed to conduct remotely delivered interventions with the aim to increase uptake of social and physical activity interventions within this population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02878-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auto-Global Examination of Mental State (Auto-GEMS): a web-based self-administered cognitive screening","authors":"Veronica Pucci,&nbsp;Giulio Contemori,&nbsp;Maria Silvia Saccani,&nbsp;Giorgio Arcara,&nbsp;Sara Mondini,&nbsp;Mario Bonato","doi":"10.1007/s40520-024-02862-z","DOIUrl":"10.1007/s40520-024-02862-z","url":null,"abstract":"<div><p>Recent methodological developments have contributed to a significant advance in computerised neuropsychological instruments and procedures, including those accessible from remote. In this paper we present Auto-GEMS, a newly developed, web-based, self-administered screening test allowing to quickly estimate an individual’s cognitive state also considering their cognitive reserve. Auto-GEMS measures cognitive functioning on eleven items similarly to the in-person paper-and-pencil version (GEMS) and to the remote (phone or video call) version (Tele-GEMS) of the same screening. We collected normative data on a sample of 1308 Italian-speaking participants (age range 18–93) to verify its psychometric properties and computed regression models on demographic variables to establish clinical cut-offs. The psychometric properties of Auto-GEMS have shown good internal consistency, test-retest reliability and convergent validity. This short and user-friendly tool has a number of potential applications. For instance, it can be useful in clinical practice to monitor the cognitive profile of patients or vulnerable individuals, or even administered in a face-to-face, standard clinical setting. It can also be used in research studies to screen participants. The testing materials and the collected data are freely available in a digital archive along with a web App to visualise the test outcome with reference to its normative data.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02862-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the German version of the SarQoL® questionnaire in sarcopenic and probable sarcopenic patients","authors":"Sebastian Martini,&nbsp;Christopher Held,&nbsp;Sabine Schluessel,&nbsp;Olivia Tausendfreund,&nbsp;Anna Schaupp,&nbsp;Michaela Rippl,&nbsp;Benedikt Schoser,&nbsp;Ralf Schmidmaier,&nbsp;Michael Drey","doi":"10.1007/s40520-024-02870-z","DOIUrl":"10.1007/s40520-024-02870-z","url":null,"abstract":"<div><h3>Background</h3><p>The German version of the SarQoL^®, a sarcopenia-specific quality of life (QoL) questionnaire, has not been validated hindering its widespread use. This study aimed to evaluate the psychometric properties of the German SarQoL^®.</p><h3>Methods</h3><p>Via a cross-sectional study participants were recruited in two geriatric outpatient facilities and one acute geriatric ward in Munich (Germany). Sarcopenia and probable sarcopenia were diagnosed with the European Working Group on Sarcopenia in Older People (EWGSOP2) algorithm. From 185 participants (age 79.8 ± 6.1), 77 had probable sarcopenia, and 51 had sarcopenia. Participants completed the SarQoL^® and the European Quality-of-Life 5-Dimension (EQ-5D) questionnaires. The validation included examination of the discriminative power, construct validity, internal consistency, test-retest reliability, and floor/ceiling effects.</p><h3>Results</h3><p>Lower SarQoL^®scores for sarcopenic (p = 0.002) and probable sarcopenic subjects (p &lt; 0.001) compared to controls indicated good discriminative power. Consistent construct validity was found for sarcopenic subjects: moderate to high correlations with domains capturing similar constructs of the EQ-5D: ‘Activities of daily living’ (r = -0.58, p &lt; 0.001), ‘Mobility’ (<i>r</i> = -0.72, <i>p</i> &lt; 0.001) and low correlations with domains related to different constructs like ‘Pain’ (<i>r</i> = -0.32, <i>p</i> &lt; 0.022). Similar correlations were found for probable sarcopenic subjects. The Cronbach’s alpha was 0.8. Test-retest reliability was excellent (intraclass coefficient correlation of = 0.96; 95% CI = 0.91–0.99), and no floor/ceiling effects were observed.</p><h3>Conclusion</h3><p>QoL was similarly reduced in both patient cohorts compared to controls. The German SarQoL^® is a valid and reliable instrument for measuring QoL in patients &gt; 65 years of age with sarcopenia and probable sarcopenia and can now be used in epidemiological studies and clinical trials in a German-speaking population.</p><h3>Trial registration</h3><p>German Clinical Trials Register (DRKS)-ID: DRKS00020504 (March 12th, 2021) .</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02870-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty status and risk of chronic lung disease: an analysis based on two national prospective cohorts","authors":"Gui-Yu Feng,&nbsp;Jing-Xiao Li,&nbsp;Guo-Sheng Li,&nbsp;Jun Liu,&nbsp;Xiang Gao,&nbsp;Guan-Qiang Yan,&nbsp;Nuo Yang,&nbsp;Tao Huang,&nbsp;Hua-Fu Zhou","doi":"10.1007/s40520-024-02867-8","DOIUrl":"10.1007/s40520-024-02867-8","url":null,"abstract":"<div><h3>Background</h3><p>The association between the frailty index (FI) and the risk of chronic lung diseases (CLDs) remains unexplored, warranting further research.</p><h3>Methods and materials</h3><p>This study investigated the relationship between FI and CLD risk using data from the China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA), comprising a combined sample of 9642 individuals. Propensity score weighting was used to ensure similar distribution of covariates across FI groups. The Wilcoxon rank-sum test was used to analyze differences in FI scores between groups with and without CLD. Kaplan–Meier curves and Cox regression analysis were employed to explore the association between frailty status and CLD incidence, with sensitivity analyses conducted for validation.</p><h3>Results</h3><p>Higher FI scores were significantly associated with increased CLD risk in both cohorts (<i>p</i> &lt; .05). Kaplan–Meier survival and Cox regression analyses indicated that frail individuals have a significantly elevated risk of CLD compared to robust individuals, particularly in certain subgroups (e.g., female) within the CHARLS cohort (<i>p</i> &lt; .05). The ELSA cohort yielded similar results (<i>p</i> &lt; .05), affirming FI as a strong predictor of CLD. Additional risk factors identified included age, smoking, and unmarried status (<i>p</i> &lt; .05). Frail individuals consistently exhibited the highest risk in both cohorts (CHARLS HR = 1.54, <i>p</i> = .003; ELSA HR = 6.64, <i>p</i> &lt; .001). The sensitivity analysis did not substantially alter the significant associations.</p><h3>Conclusion</h3><p>These findings emphasize the critical role of frailty in the development of CLD, suggesting that targeted interventions could reduce CLD risk.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02867-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the Brief-BESTest partially instrumented with accelerometry to detect balance deterioration in middle-age","authors":"Guy Baranes,&nbsp;Roee Hayek,&nbsp;Itai Gutman,&nbsp;Silvi Frenkel-Toledo,&nbsp;Shmuel Springer","doi":"10.1007/s40520-024-02868-7","DOIUrl":"10.1007/s40520-024-02868-7","url":null,"abstract":"<div><h3>Background</h3><p>Most standardized balance tests cannot detect subtle balance deterioration in middle age, or identify those at higher risk for accelerated balance decline due to a ceiling effect.</p><h3>Aims</h3><p>To determine whether the Brief Balance Evaluation Systems Test (Brief-BESTest), partially instrumented with accelerometry, can detect balance deterioration in middle age and identify individuals with poor balance.</p><h3>Methods</h3><p>We studied young (25.3 ± 2.3 years), early middle-aged (47.7 ± 2.6 years), and late middle-aged adults (60.6 ± 3.6 years), with 25 participants in each age group. Subjects wore an accelerometer on their lower back while performing the Brief-BESTest. Balance measurements included the Brief-BESTest total and sub-measures scores, and postural sway during the Brief-BESTest standing tasks, calculated by the 95% confidence ellipse trajectory of the center of mass (COM-95% ellipse).</p><h3>Results</h3><p>Compared to the two middle-aged groups, young adults had better total Brief-BESTest and sub-measures scores, apart from the Stability-in-Gait sub-measure, and less postural sway during the Sensory-Orientation sub-measure. The total Brief-BESTest scores as well as the Biomechanical-Constraints and Sensory-Orientation sub-measures differed also between early and late middle-aged adults. Both the Brief-BESTest total scores and the Sensory-Orientation postural sway values demonstrated increased variation with age, allowing to identify subjects with poor balance. A moderate negative correlation (<i>r</i> = -0.43) was found between the Brief-BESTest total score and the COM-95% ellipse size, and a moderate agreement (<i>k</i> = 0.56) in identifying subjects with poor performance in the early but not the late middle age group.</p><h3>Conclusions</h3><p>The Brief-BESTest test combined with accelerometry could be a suitable screening tool to identify middle-aged people with early balance deterioration and potentially identify those with poor balance and a possible higher risk for falls. Clinicians and policymakers can use our findings to implement balance assessment programs in patients &lt; 65 years, leading to preventive strategies before the risk increases.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02868-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes in hs-CRP and risk of all-cause mortality among middle-aged and elderly adults: findings from a nationwide prospective cohort and mendelian randomization","authors":"Zhonghai Wang,&nbsp;Feng Xiong,&nbsp;Quanbo Zhang,&nbsp;Han Wang","doi":"10.1007/s40520-024-02865-w","DOIUrl":"10.1007/s40520-024-02865-w","url":null,"abstract":"<div><h3>Introduction</h3><p>The general population experiences mortality rates that are related to high levels of high-sensitivity C-reactive protein (hs-CRP). We aim to assess the linkage of longitudinal trajectories in hs-CRP levels with all-cause mortality in Chinese participants.</p><h3>Methods</h3><p>We utilized data from the China Health and Retirement Longitudinal Study (CHARLS). The exposures were dynamic changes in the hs-CRP and cumulative hs-CRP from 2012 to 2015, and the outcome was all-cause mortality. All participants were categorized into four trajectories according to hs-CRP levels. Multivariable logistic regression analysis, adjusted for potential confounders, was employed to evaluate the relationship of different trajectories of hs-CRP with mortality risk. A two-sample Mendelian randomization (TSMR) method and SHapley Additive exPlanations (SHAP) for identifying determinants of mortality risk were also employed.</p><h3>Results</h3><p>The study included 5,445 participants with 233 deaths observed, yielding a mortality proportion of 4.28%. Compared to individuals maintaining low, stable levels of hs-CRP (Class 1), individuals with sustained elevated levels of hs-CRP (Class 4), those experiencing a progressive rise in hs-CRP levels (Class 2), or those transitioning from elevated to reduced hs-CRP levels (Class 3) all faced a significantly heighted death risk, with adjusted Odds Ratios (ORs) ranging from 2.34 to 2.47 across models. Moreover, a non-linear relationship was found between them. Further TSMR analysis also supported these findings. SHAP showed that hs-CRP was the fifth most important determinant of mortality risk.</p><h3>Conclusions</h3><p>Our study shows all-cause mortality increases with dynamic changes in hs-CRP levels among middle-aged and elderly adults in China, and cumulative hs-CRP shows an L-shaped relationship with all-cause mortality.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02865-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}