Aging Clinical and Experimental Research最新文献

{"title":"Human-animal relationships in older persons: from pet companionship to animal-assisted interventions. A position statement","authors":"Andrea Ungar,&nbsp;I. Ambrosino,&nbsp;G. Rivasi,&nbsp;L. Ceolin,&nbsp;G. Bellelli,&nbsp;E. Bisconti,&nbsp;M. C. Catalani,&nbsp;A. Cherubini,&nbsp;L. Colombo,&nbsp;L. Contalbrigo,&nbsp;A. M. Cotroneo,&nbsp;C. Mariti,&nbsp;L. Mechelli,&nbsp;M. Melosi,&nbsp;A. Morandi,&nbsp;F. Mutinelli,&nbsp;C. Mussi","doi":"10.1007/s40520-026-03386-4","DOIUrl":"10.1007/s40520-026-03386-4","url":null,"abstract":"<div>\u0000 \u0000 <p>The rising awareness of how animal companionship enhances human well-being has drawn significant attention from people of all ages. Literature data about the impact of human-animal relationships is still limited by the number of studies and the settings explored, especially among older adults. However, encouraging results were provided by some preliminary studies investigating pet ownership and AAI in old age. In this manuscript we provide a detailed overview of the effects of the human-animal relationship in older people. We review data on the benefits of pet ownership in later life and on Animal-Assisted Interventions (AAI) as a non-pharmacological strategy to support traditional approaches to the most prevalent disabling conditions in the older population, focusing on the technical requirements that guarantee the quality and safety of AAI. Indeed, AAI may allow for the advantages of the positive effects of the human-animal bond in the older population without the challenges of pet companionship ownership, which may not always be suitable for some older adults.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic control in the context of frailty: a mortality risk assessment in older diabetic patients","authors":"Hong-jie Yu,&nbsp;Eric Tsz-Chun Lai,&nbsp;Ruby Yu,&nbsp;Jean Woo","doi":"10.1007/s40520-026-03385-5","DOIUrl":"10.1007/s40520-026-03385-5","url":null,"abstract":"<div><h3>Background</h3><p>Glycemia control in older diabetic adults is complicated by uncertainty regarding how intensive glycemic control should be, particularly in those with frailty. This study investigated the association between HbA1c levels and all-cause mortality, assessing the modifying effect of frailty.</p><h3>Methods/design</h3><p>This retrospective study used Hong Kong hospitalization data (2012–2021) for older adults. Patients with first-recorded diabetes during 2014–2020 were classified as index cases. Frailty was evaluated using the Hospital Frailty Risk Score (HFRS), derived from two years of hospitalization diagnoses before the index diabetes and categorized as follows: no (HFRS = 0), mild (HFRS &lt;5), and moderate andsevere frailty (HFRS ≥5). Glycemic control was assessed via time-weighted mean HbA1c and early variability of the first three measurements. The relationship between HbA1c, variability, and mortality was examined using multivariable Cox regression, with nonlinear relationships modeled via restricted cubic splines.</p><h3>Results</h3><p>A J-shaped curve was observed for HbA1c-mortality association (<i>p</i>-nonlinearity &lt;0.001), with increased risk at low/high extremes, significantly influenced by frailty (<i>p</i>-interaction &lt;0.001). In non-frail patients, lower mortality was noted across an HbA1c range of 5.4%–10.5%, with a minimum at 7.8% (HR = 0.59, 95% CI: 0.56–0.61). For those with moderate andsevere frailty, the safety zone narrowed to 6.1%–9.3%, with a nadir at 7.7% (HR = 0.73, 95% CI: 0.68–0.79). Early glycemic variability significantly affected mortality risk only in non-frail individuals.</p><h3>Conclusion</h3><p>Frailty alters the mortality risk associated with glycemic control, highlighting the need for frailty-stratified management strategies in older diabetic adults to optimize health outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From meta-analysis to knowledge graphs: reimagining social isolation research in older adults","authors":"Zian Shou,&nbsp;Yisheng Liang,&nbsp;Chang Lin,&nbsp;Yibo He","doi":"10.1007/s40520-026-03394-4","DOIUrl":"10.1007/s40520-026-03394-4","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03394-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of eight insulin resistance surrogate indices in predicting incident stroke among middle-aged and older individuals without diabetes: a nationwide prospective cohort study","authors":"Jun Ran,&nbsp;Jinxi Wang,&nbsp;Xuemei Zhao,&nbsp;Qiong Zhou,&nbsp;Yan Huang,&nbsp;Mei Zhai,&nbsp;Xin Quan,&nbsp;Yuhui Zhang","doi":"10.1007/s40520-026-03376-6","DOIUrl":"10.1007/s40520-026-03376-6","url":null,"abstract":"<div><h3>Background</h3><p>Although insulin resistance (IR) surrogate indices have demonstrated associations with and predictive value for incident stroke, previous studies focused mainly on diabetic or general populations, with limited comprehensive comparisons in non-diabetic populations.</p><h3>Aims</h3><p>To systematically compare eight IR surrogate indices for predicting incident stroke in middle-aged and older individuals without diabetes.</p><h3>Methods</h3><p>Using data from the China Health and Retirement Longitudinal Study (CHARLS), we analyzed 6,377 non-diabetic participants aged ≥ 45 years followed from 2011 to 2020. Multivariate Cox proportional hazards regression models and restricted cubic spline (RCS) analyses were used to assess associations between IR surrogate indices and incident stroke. Harrell’s C-index, time-dependent C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate and compare the predictive performance of different IR surrogate indices for incident stroke. Subgroup and sensitivity analyses were conducted to verify robustness.</p><h3>Results</h3><p>Over 9 years of follow-up, 550 incident stroke events (8.6%) were recorded. All eight IR surrogate indices were significantly associated with incident stroke. Regarding predictive performance, the estimated glucose disposal rate (eGDR) model significantly outperformed the base model and other IR surrogate index models across multiple evaluation dimensions, including overall C-index (0.660, 95% CI: 0.638–0.681), time-dependent C-index, NRI, and IDI. Subgroup analyses and sensitivity analyses confirmed the robustness of the eGDR model’s predictive advantages.</p><h3>Conclusions</h3><p>eGDR outperformed other IR surrogate indices in predicting incident stroke among middle-aged and older individuals without diabetes, suggesting potential utility for early stroke risk assessment.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons","authors":"Laurence Lapauw,&nbsp;Lode Vermeiren,&nbsp;Laura Vercauteren,&nbsp;Nadjia Amini,&nbsp;Lisa Peeters,&nbsp;Sebastiaan Dalle,&nbsp;Katrien Koppo,&nbsp;Muriel Derrien,&nbsp;Jolan Dupont,&nbsp;Jeroen Raes,&nbsp;Evelien Gielen","doi":"10.1007/s40520-026-03368-6","DOIUrl":"10.1007/s40520-026-03368-6","url":null,"abstract":"<div><h3>Backgrounds</h3><p>Serum and fecal biological markers that reflect underlying drivers of sarcopenia, may aid in novel predictive or diagnostic tools for sarcopenia.</p><h3>Aims</h3><p>To explore the potential of five specific myokines and fecal calprotectin (fCPT) as biomarkers for diagnosing the presence of at least probable sarcopenia in community-dwelling individuals aged ≥ 65 years.</p><h3>Methods</h3><p>This cross-sectional, exploratory study included 156 participants (median age 73y), of whom 59 (20♂, 39♀) had at least probable sarcopenia per EWGSOP2 criteria, and 97 (33♂, 64♀) controls. Myostatin, irisin, Brain-Derived Neurotrophic Factor (BDNF), Insulin-like Growth Factor-1 (IGF-1), Fibroblast Growth Factor-21 (FGF-21), and fCPT were measured using Enzyme-Linked ImmunoSorbent Assay (ELISA). Muscle mass and function were assessed via appendicular lean mass (ALM), hand grip strength (HGS), 5-time chair stand test (CST), gait speed, and the Short Physical Performance Battery (SPPB). Linear and logistic regressions analyses were performed. Diagnostic accuracy was evaluated using Area’s Under the Curve (AUC).</p><h3>Results</h3><p>Participants with fCPT &lt; 50 µg/g walked faster than those with fCPT ≥ 200 µg/g. Higher fCPT associated with slower gait speed (β: -0.003; 95% CI [-0.001; -0.00002]), while IGF-1 associated with higher HGS (β: 0.077; 95% CI [0.039; 0.116]). BDNF alone diagnosed at least having probable sarcopenia (AUC: 0.63; sensitivity 53%, specificity 71%). A multi-biomarker panel comprising BDNF, irisin, FGF-21 and fCPT modestly improved accuracy (AUC: 0.71; sensitivity 64%, specificity 77%), but this improvement was not statistically significant compared with the single biomarkers BDNF (<i>p</i> = 0.330) and fCPT (<i>p</i> = 0.180).</p><h3>Discussion</h3><p>The multi-biomarker panel significantly diagnosed at least having probable sarcopenia, but with high false negative (36%) and positive (23%) rates, respectively.</p><h3>Conclusion</h3><p>The clinical relevance of this specific multi-biomarker panel may be limited due to moderate diagnostic accuracy. Validation in larger cohorts is needed.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review","authors":"Fanny Buckinx,&nbsp;Anne-Françoise Rousseau,&nbsp;Edouard Louis,&nbsp;Arnaud De Roover,&nbsp;Olivier Detry,&nbsp;Rodolphe Durieux,&nbsp;Sophie Gillain,&nbsp;Abdourahamane Kaba,&nbsp;Jean-François Kaux,&nbsp;Vincent Tchana-Sato,&nbsp;Olivier Bruyère","doi":"10.1007/s40520-025-03314-y","DOIUrl":"10.1007/s40520-025-03314-y","url":null,"abstract":"<div><h3>Background</h3><p>Older adults undergoing major abdominal, cardiac, or vascular surgery are highly vulnerable to postoperative complications, prolonged hospitalisation, functional decline, and mortality. Sarcopenia and frailty reduce physiological reserve, underscoring the potential role of prehabilitation in improving resilience to surgical stress and postoperative outcomes.</p><h3>Objective</h3><p>To evaluate the effects of exercise-based prehabilitation, alone or combined with nutritional, psychological, or educational components, on postoperative outcomes, including complications, length of stay, readmissions, mortality, quality of life, and economic indicators, as well as on body composition, functional reserve, and biological markers, in adults aged ≥ 65 years undergoing major abdominal, cardiac, or vascular surgery.</p><h3>Methods</h3><p>Medline, Scopus and EMBASE were searched for Randomised Controlled trials assessing prehabilitation programmes in older adults undergoing major abdominal, cardiac or vascular surgery. Data on study characteristics, interventions, outcomes, and methodological quality were extracted and synthesized narratively.</p><h3>Results</h3><p>Nine studies (<i>n</i> = 36–182; mean/median age 68–82) were included. Interventions lasted 2–6 weeks and involved exercise alone or multimodal programmes, delivered in-person, remotely, or via hybrid approaches. Vascular surgery studies showed modest reductions in complications and hospital stay, whereas abdominal surgery studies generally reported no significant improvements, except for isolated reductions in severe complications or gains in functional reserve. No studies involving cardiac surgery were identified.</p><h3>Conclusion</h3><p>Prehabilitation in older adults remains understudied, especially in frail patients, the oldest old, and cardiac surgery. Robust trials are needed to assess individualized, multimodal, sarcopenia-targeted interventions and to integrate biological markers to clarify underlying mechanisms.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of resistance training combined with carbohydrate and protein supplementation on the HOMA-IR, glycemic, lipid profile and hypertrophy of older adults with Type II Diabetes: secondary data analysis of a triple-blind RCT","authors":"Juliana Leme Rosa,&nbsp;Matheus Henrique dos Santos Lino,&nbsp;Marcus Vinicius Grecco,&nbsp;Adriana Machado Saldiba de Lima,&nbsp;Joselma Rodrigues dos Santos,&nbsp;Vanderlei Carneiro da Silva,&nbsp;Julia Maria D’Andréa Greve,&nbsp;Félix Salvador Chavane,&nbsp;Guilherme Eustáquio Furtado,&nbsp;Angelica Castilho Alonso","doi":"10.1007/s40520-026-03374-8","DOIUrl":"10.1007/s40520-026-03374-8","url":null,"abstract":"<div><h3>Introduction</h3><p>Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease associated with major health complications, including cardiovascular risk.</p><h3>Objective</h3><p>To evaluate the effects of resistance training (RT) combined with protein or carbohydrate supplementation on muscle strength, hypertrophy, and glycemic and lipid profiles in older adults with T2DM.</p><h3>Methods</h3><p>A triple-blind randomized clinical trial was conducted with 60 men with T2DM, allocated into three groups: Protein Group (20 g whey protein), Maltodextrin Group (20 g maltodextrin), and Control Group (colored water). All participants completed a 12-week RT program performed twice weekly. Each session included six exercises, with three sets of 8–12 repetitions, guided by subjective perception of effort. Muscle strength progression was monitored through training loads. Glycemic response, HOMA-IR, and lipid profile were analyzed, while muscle thickness of the biceps brachii and vastus lateralis was measured using ultrasound.</p><h3>Results</h3><p>The Protein Group showed a significant reduction in HOMA-IR (<i>p</i> = 0.03), indicating improved insulin resistance. Lipid profile variables showed no significant changes across groups. Most exercises demonstrated significant load progression, except rowing and standing curls. Muscle thickness did not show significant differences in either muscle evaluated. RT improved muscle strength regardless of supplementation type but did not produce significant hypertrophy. Protein supplementation significantly reduced HOMA-IR, indicating early improvements in insulin sensitivity, whereas carbohydrate supplementation showed no metabolic effect. Lipid profile parameters remained unchanged, and no significant changes were observed in HbA1c or fasting glycemia.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical facility preferences among older patients with diabetes: A discrete choice experiment in a Japanese primary care setting","authors":"Rie Tanaka,&nbsp;Gerelmaa Gunsmaa,&nbsp;Shinobu Motohashi,&nbsp;Katsuya Yamazaki,&nbsp;Masao Ichikawa","doi":"10.1007/s40520-026-03369-5","DOIUrl":"10.1007/s40520-026-03369-5","url":null,"abstract":"<div><h3>Background</h3><p>To support aging patients living with diabetes, understanding their medical facility preferences is relevant, considering their healthcare needs and mobility status.</p><h3>Aims</h3><p>We conducted a discrete choice experiment among adult patients with diabetes in a Japanese primary care setting.</p><h3>Methods</h3><p>A binary logit model was used to estimate the relative importance of medical facility attributes based on age group, driving status, and presence of companions during medical visits.</p><h3>Results</h3><p>Of 1,027 participants with the median age of 70 years (interquartile range: 60, 75), 29% were aged ≥ 75 years, 65% were men, 21% developed diabetic complications, and 51% had multimorbidity. Generally, the participants preferred clinics over hospitals, face-to-face consultations over online consultations, and shorter travel and waiting times. Older patients were more flexible with travel and waiting times than younger patients. Although online consultations were less preferred overall, older patients who do not drive were relatively receptive to online consultations, and those who were accompanied by someone during medical visits showed a preference for large hospitals.</p><h3>Discussion</h3><p>Patient preferences vary by age and mobility status and may influence medical facility choices. Online consultations and having a companion during medical visits would be helpful for older patients with diabetes and mobility challenges.</p><h3>Conclusions</h3><p>The discrete choice experiment revealed the medical facility preferences among older patients with mobility challenges. Our findings suggest new avenues for older patients with diabetes to access optimal care.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03369-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use and in-hospital complications in patients aged ≥ 80 years admitted to Internal medicine: a multicentre observational study in Spain","authors":"Iván Fernández Castro,&nbsp;Victoria Lobo Antuña,&nbsp;Sonia Martín Rodríguez,&nbsp;José López Castro,&nbsp;Elena Caro Martínez,&nbsp;María Belén Alonso Ortiz,&nbsp;Guillem Policarpo-Torres,&nbsp;José Miguel Seguí Ripoll,&nbsp;Sandra Inés Revuelta,&nbsp;Candelaria Martín González,&nbsp;Julia Casado-Carbajo,&nbsp;Cristina Macía-Rodríguez,&nbsp;Lucía Alvela Suárez,&nbsp;Ignacio Novo-Veleiro","doi":"10.1007/s40520-026-03373-9","DOIUrl":"10.1007/s40520-026-03373-9","url":null,"abstract":"<div><h3>Background</h3><p>Alcohol consumption among older adults aged ≥ 80 years remains insufficiently characterised, despite increased susceptibility to alcohol-related harm. This study aimed to assess the prevalence of alcohol use and alcohol use disorder (AUD) and to examine associations with in-hospital complications in patients aged ≥ 80 years admitted to Internal Medicine.</p><h3>Methods</h3><p>This multicentre prospective observational study was conducted from June 2022 to July 2023 across 19 hospitals. Consecutive patients aged ≥ 80 years admitted to Internal Medicine were included. Alcohol use was assessed through structured interviews and validated screening instruments, including the Alcohol Use Disorders Identification Test (AUDIT) and the CAGE questionnaire. Data on comorbidities, medication use, functional status, laboratory parameters, and in‐hospital complications were collected. Multivariable logistic regression was performed to identify independent predictors of in-hospital complications.</p><h3>Results</h3><p>A total of 916 patients (median age 86 years; 54% female) were analysed. Active alcohol use at admission was reported by 28%, and 8% met AUDIT criteria for AUD. Alcohol use was documented in medical records in 36% of cases. Overall, 47% developed ≥ 1 complication. Alcohol withdrawal syndrome (9%) and insomnia (36%) were significantly more frequent among active drinkers. Independent predictors of in-hospital complications included AUDIT score ≥ 8 [Odds Ratio (OR) 3.8; 95% Confidence Interval (CI) 1.8–8.3], in‐hospital benzodiazepine use (OR 2.3; 95% CI 1.7–3.2), neuroleptic use (OR 4.1; 95% CI 2.9–5.7), and discharge diagnoses of infection or neurological disease.</p><h3>Conclusions</h3><p>Alcohol consumption is common yet under-recognised in patients aged ≥ 80 years and is associated with increased odds of in‐hospital complications. Routine screening with the AUDIT in this population may improve risk stratification and facilitate early identification of patients at elevated risk of in-hospital complications.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach","authors":"Nicholas Fuggle,&nbsp;François Rannou,&nbsp;Emmanuel Maheu,&nbsp;Alberto Migliore,&nbsp;Nasser Al-Daghri,&nbsp;Majed Alokail,&nbsp;Patrick Ammann,&nbsp;Francis Berenbaum,&nbsp;Angie Botto-van Bemden,&nbsp;Maria Luisa Brandi,&nbsp;Nansa Burlet,&nbsp;Roland Chapurlat,&nbsp;Cyrus Cooper,&nbsp;Elaine Dennison,&nbsp;Nicholas C Harvey,&nbsp;Gun-il Im,&nbsp;Andreas Kurth,&nbsp;Radmila Matijevic,&nbsp;Daniel Messina,&nbsp;Jordi Monfort Faure,&nbsp;Régis P. Radermecker,&nbsp;Ralf Schmidmaier,&nbsp;Stuart Silverman,&nbsp;Julien Wegrzyn,&nbsp;Leith Zakraoui,&nbsp;René Rizzoli,&nbsp;Jean-Yves Reginster,&nbsp;Olivier Bruyère,&nbsp;Ali Mobasheri","doi":"10.1007/s40520-026-03366-8","DOIUrl":"10.1007/s40520-026-03366-8","url":null,"abstract":"<div>\u0000 \u0000 <p>Hyaluronic acid (HA) is a linear polysaccharide which occurs naturally as a constituent of synovial fluid. The HA concentration in the joint decreases inexorably during the progression of knee osteoarthritis (OA) and so, for nearly five decades, HA has been trialled and used in the treatment of knee OA. There are strong data from clinical trials, meta-analyses and umbrella reviews to support the use of intra-articular hyaluronic acid (IAHA) in the treatment of patients with knee OA, though not in patients with acute, active OA experiencing a flare. The majority of the literature suggests that IAHA has a positive safety profile despite a few meta-analyses suggesting an increased risk of serious adverse effects. Further qualitative analysis integrating patient preferences for multi-modal and/or non-surgical management is required in order to further explore these findings. IAHA has been combined with a number of additional agents, including mannitol, sorbitol, chondroitin sulphate, tranexamic acid, polynucleotides and hybrid IAHA formulations. These show variable performance beyond the baseline effect of their constituents. It is crucial to consider the patient’s preference when considering treatments for knee OA. Specific to IAHA, patients seek minimally invasive, lower-risk, and non-steroidal options with at least moderate efficacy and advantageous safety profiles.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03366-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}