Aging Clinical and Experimental Research最新文献

{"title":"Correction: Frailty and caregiver relationship quality in older patients diagnosed with transthyretin cardiac amyloidosis.","authors":"Carlo Fumagalli, Martina Smorti, Lucia Ponti, Francesca Pozza, Alessia Argirò, Giacomo Credi, Carlo Di Mario, Raffaele Marfella, Niccolò Marchionni, Iacopo Olivotto, Federico Perfetto, Andrea Ungar, Francesco Cappelli","doi":"10.1007/s40520-025-03084-7","DOIUrl":"10.1007/s40520-025-03084-7","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"207"},"PeriodicalIF":3.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there inequity in access to health care for geriatric patients from the perspective of operation waiting time?","authors":"Ozan Baris Namdaroglu, Nurettin Kahramansoy, Selen Ozturk, Fatma Dikiser, Hilmi Yazıcı","doi":"10.1007/s40520-025-03117-1","DOIUrl":"10.1007/s40520-025-03117-1","url":null,"abstract":"<p><strong>Background: </strong>People worldwide face disparities in access to healthcare. Advanced age may be a disadvantage regarding access to healthcare. The reasons for inequity may vary in heterogeneous societies. We aimed to investigate whether advanced age constitutes a disadvantage in a homogeneous population.</p><p><strong>Materials and methods: </strong>Data from a tertiary hospital between January 2021 and November 2023 were retrospectively collected. Patients were diagnosed with cholelithiasis and inguinal hernia. The patients were categorized into groups based on age (< 65 years, ≥ 65 years) and further subdivided into age subgroups (65-74 years, 75-84 years, and ≥ 85 years). Comorbidities, ASA scores, and waiting times before surgery were analyzed across the groups and subgroups.</p><p><strong>Results: </strong>A total of 1401 patients were analyzed, of whom 261 (18.6%) were aged ≥ 65 years. Older patients more frequently had hypertension, diabetes mellitus, and cardiac and pulmonary comorbidities (p < 0.001). The proportion of patients classified as ASA II and III was significantly higher in the older age group. The waiting time for surgery was similar (20 days) between the < 65 and ≥ 65 age groups. Furthermore, there were no significant differences in waiting times among the subgroups within the older age category.</p><p><strong>Conclusion: </strong>Older patients experienced similar waiting times for surgery compared to younger patients, suggesting equity in access to healthcare. This is thought to be associated with the homogeneity of the population and urban residency.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"208"},"PeriodicalIF":3.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccination in older people: a geriatrician's perspective.","authors":"Nicola Veronese, Ligia Juliana Dominguez, Antonina Ganci, Gerlando Speziale, Pasquale Mansueto, Salvatore Piro, Giorgio Basile, Mario Barbagallo","doi":"10.1007/s40520-025-03086-5","DOIUrl":"10.1007/s40520-025-03086-5","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"202"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound- and clinical-defined disease activities are associated with altered bone microarchitecture and lower bone mineral density in patients with rheumatoid arthritis.","authors":"O Malaise, C Rinkin, C Gerard, F Chauveheid, L Seidel, M Malaise, C Ribbens","doi":"10.1007/s40520-025-03105-5","DOIUrl":"10.1007/s40520-025-03105-5","url":null,"abstract":"<p><strong>Background/aims: </strong>We investigate if rheumatoid arthritis (RA) activity, defined clinically and with ultrasound, is associated with bone macro- and micro-architecture impairment on high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual X-ray densitometry (DEXA).</p><p><strong>Methods: </strong>Disease activity was evaluated in 61 RA patients, with clinical indices and ultrasound (hands and wrists). Bone mineral density (BMD) and architecture were analyzed with HR-pQCT and DEXA.</p><p><strong>Results: </strong>Ultrasound RA disease activity parameters [synovitis, power doppler (PD)-positive joints, sum of positive power doppler signals and tenosynovitis] were associated with altered HR-pQCT bone density and structure at tibia or radius (trabecular volumetric BMD, trabecular bone volume fraction, trabecular thickness and cortical porosity). In addition, wrist ultrasound activity was specifically locally associated with impaired local bone microarchitecture at distal ipsilateral radius. Clinical and functional RA disease activity parameters (number of swollen joints, Health Assessment Questionnaire and disease activity score DAS28-CRP) were also correlated with HR-pQCT parameters (total and trabecular volumetric BMD, trabecular thickness and cortical thickness). At the hip, BMD correlated with VAS-fatigue and DAS28-ESR. The number of synovitis detected by ultrasound was higher when total hip T-score was lower than - 1.</p><p><strong>Discussion: </strong>Ultrasound and clinical disease activity parameters were associated with impaired HR-pQCT parameters (distal radius and tibia), with lower trabecular and cortical bone densities and impaired bone microarchitecture (organization of spans and cortical porosity). In addition to systemic contribution to bone impairment, a local correlation between wrist US activity and HR-pQCT at distal radius was observed.</p><p><strong>Conclusion: </strong>Patients with active RA, especially with US evaluation, are at higher risk for altered bone density and structure.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"199"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia association with physical and psychological indices in community-dwelling aged population, Birjand Longitudinal Aging Study (BLAS).","authors":"Amir Nasrollahizadeh, Sepide Javankiani, Pouya Ebrahimi, Farshad Sharifi, Parnian Soltani, Majid Amiri, Mitra Moodi, Masoumeh Khorashadizadeh, Hossein Fakhrzadeh, Pedram Ramezani, Fatemeh Naderi, Maryam Taheri, Mahbube Ebrahimpur, Moloud Payab","doi":"10.1007/s40520-025-03072-x","DOIUrl":"10.1007/s40520-025-03072-x","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a progressive syndrome associated with adverse outcomes in older adults. This study aimed to assess the prevalence of sarcopenia and its associated risk and protective factors among community-dwelling elderly individuals.</p><p><strong>Methods: </strong>As a part of the Birjand Longitudinal Aging Study (BLAS), this retrospective cross-sectional study assesses patients older than 60 years old. Basic characteristics, nutritional status, comorbidities, and sociodemographic data were collected. Logistic regression analyses were performed to identify factors associated with sarcopenia severity.</p><p><strong>Results: </strong>A total of 1,348 participants (mean age: 69.73 ± 7.53 years) were classified into four groups: robust (58.85%), probable sarcopenia (31.03%), sarcopenia (4.76%), and severe sarcopenia (5.36%). On univariate analysis, being overweight or obese, any formal education, regular physical activity, and hypertension were accompanied by lower odds of sarcopenia, whereas dementia and anemia increased its odds. In the fully adjusted model, age > 70 years (OR 1.39, 95% CI 1.05-1.83) and > 80 years (OR 4.93, 95% CI 3.15-7.71), malnutrition risk (OR 1.36, 95% CI 1.02-1.82), living alone (OR 1.88, 95% CI 1.12-3.22) and dementia (OR 1.03 per 6-CIT point, 95% CI 1.01-1.05) were independent risk factors, while education lower than diploma (OR 0.63, 95% CI 0.46-0.86) and diploma (OR 0.39, 95% CI 0.22-0.67), exercise more than once per week (with different ORs regarding variable physical activity frequencies) and hypertension (OR = 0.62, 95% CI: 0.47-0.81, P-value < 0.01) were related to lower odds of sarcopenia.</p><p><strong>Conclusions: </strong>Those aged > 70, at risk of malnutrition, and having dementia had higher odds of sarcopenia. In contrast, having an educational level of a diploma or lower, ≥ one session of physical activity per week, and having hypertension showed a reverse association with sarcopenia. Findings underscore the importance of targeted interventions to mitigate sarcopenia risk in aging populations.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"198"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A concise instrument for screening cognitive impairment: validation in a geriatric population.","authors":"Ayse Dikmeer, Suna Burkuk, Pelin Unsal, Mert Polat, Cafer Balci, Meltem Halil, Mustafa Cankurtaran, Burcu Balam Dogu","doi":"10.1007/s40520-025-03056-x","DOIUrl":"10.1007/s40520-025-03056-x","url":null,"abstract":"<p><strong>Background: </strong>The Short Portable Mental Status Questionnaire (SPMSQ) is a brief instrument designed to evaluate cognitive impairment in older adults. This study evaluates the validity and reliability of the Turkish SPMSQ and determines optimal cut-off values.</p><p><strong>Methods: </strong>Patients aged 65 years and older were enrolled consecutively. Following the translation and cultural adaptation procedure, the Turkish versions of the SPMSQ and Standardised Mini Mental State Examination (SMMSE) were administered to evaluate cognitive status. The SPMSQ's diagnostic accuracy was evaluated by calculating the area under ROC curve (AUC).</p><p><strong>Results: </strong>A total of 197 patients were included, comprising 48 with dementia and 149 controls. In 67% of the study population, total education time was under five years. ROC analysis of the overall study population identified an optimal cut-off point of the SPMSQ for differentiating dementia at ≥ 4 errors, yielding a sensitivity of 83.3% and specificity of 90.6% (AUC: 0.949). The cut-off point was determined as ≥ 4 errors for patients with ≤ 5 years of education time (sensitivity: 87.2%, specificity: 84.9%, AUC: 0.933) and ≥ 3 errors for patients with > 5 years of education time (sensitivity: 100%, specificity: 98.2%, AUC: 0.997). The SPMSQ and SMMSE scores showed a significant positive correlation (r = 0.661, p < 0.001). The cut-off point for the SMMSE was ≤ 25, demonstrating 83.3% sensitivity and 97.3% specificity, with an AUC of 0.947. This was not statistically different from the SPMSQ AUC (p = 0.93).</p><p><strong>Conclusion: </strong>The SPMSQ is a reliable instrument for dementia screening in older adults and is not inferior to SMMSE. These findings suggest that the SPMSQ can be effectively utilized in primary care and geriatric clinics as a quick and reliable cognitive screening tool, especially in populations with varying education levels.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"196"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Work is associated with a more robust rest-activity rhythm and high-intensity physical activity among older adults.","authors":"Pin-Shiuan Lee, Yen-Ling Liu, Yi-Ling Chen, Wan-Ju Cheng","doi":"10.1007/s40520-025-03083-8","DOIUrl":"10.1007/s40520-025-03083-8","url":null,"abstract":"<p><strong>Background: </strong>Work participation is a major element of active aging in aging societies. However, the impact of work on physical activity and rest-activity rhythm has not been well-studied in the older population.</p><p><strong>Aims: </strong>To investigate the association of work status with the distribution of physical activity and rest-activity rhythm.</p><p><strong>Methods: </strong>The study recruited 35 working and 72 non-working community-dwelling adults older than 60 years old. Biological rhythm was evaluated by dim light melatonin onset (DLMO). Activity distribution and rest-activity rhythm indicators were derived from 14-day actigraphy data, and differences between working and non-working groups were analyzed. The association of activity distribution and rest-activity rhythm indicators with mood symptom was examined.</p><p><strong>Results: </strong>Compared to non-working older adults, those who were working exhibited an earlier wake-up time (05:24 h vs. 06:11 h, p = 0.001) and higher levels of daytime activity (most active 10-hour activity count: 25605 vs. 16838, p < 0.001), but similar DLMO (20:20 h vs. 20:24 h, p = 0.914). Work is associated with a more robust rest-activity rhythm as assessed by interdaily stability (β = 0.18, p < 0.001) and autocorrelation coefficients (β = 0.09, p = 0.002). Regarding activity distribution, work is associated with high-intensity activity in shorter bouts, as shown by a lower Gini index (β = -0.04, p = 0.003) and a higher intensity gradient (β = 0.54, p < 0.001).</p><p><strong>Conclusions: </strong>Working and non-working older adults showed similar biological circadian rhythms, but working ones had a more robust rest-activity rhythm and higher levels and intensity of physical activity.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"200"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Dynapenic abdominal obesity and fall risk among older adults: a longitudinal study in Birjand.","authors":"Hadiseh Rahimi Chaksari, Pouya Ebrahimi, Tahereh Yavari, Farshad Sharifi, Pedram Ramezai, Reza Pirdehghan, Fatemeh Naderi, Mitra Moodi, Masoumeh Khorashadizadeh, Moloud Payab, Mahbube Ebrahim Pour","doi":"10.1007/s40520-025-03092-7","DOIUrl":"10.1007/s40520-025-03092-7","url":null,"abstract":"<p><strong>Introduction: </strong>Dynapenic abdominal obesity (DAO) is the coexistence of obesity and dynapenia, defined as muscle weakness. Both abdominal obesity and dynapenia may contribute to falls in older adults. This study assesses the relationship between DAO and the risk of falls in the population ≥ over 60 who participated in the Birjand Longitudinal Aged Study (BLAS) trial.</p><p><strong>Methods: </strong>This prospective cohort study involves 1,418 elderly participants aged ≥ 60. The sample, representative of the aged population BLAS program, was selected using stratified random cluster sampling. Data on fall events - including the date, time, cause, and associated injuries - were collected through a structured researcher-designed data collection form via telephone contact with the participants or their families. Clinical examination findings and paraclinical test results per the study protocol were also available to researchers.</p><p><strong>Results: </strong>Of the 1,418 participants, 697 (51.71%) were women, and 651 (48.29%) were men, with a mean age of 69.73. The presence of DAO was significantly associated with a higher risk of falls, with a coefficient of OR = 2.65 (CI 95% 1.03-6.84, P = 0.044). Among the participants, 757(56.2%), 422 (31.3%), and 169 (12.5%) fell in the age groups between 60 and 69, 70-79, and ≥ 80 years, respectively. Male gender (OR: 0.45, 95%CI: 0.23-0.90, P-value: 0.23), on the other hand, was linked to a lower risk of falls, and this association was statistically significant. Furthermore, a higher risk of falls was observed among those with higher scores on the \"Time to Get Up and Go\" test (OR: 1.80, 95%CI: 1.11-2.92, P-value: 0.16), as well as those with depression (OR: 2.13, 95%CI: 1.30-3.49, P-value: 0.003), and anemia (OR: 1.89, 95%CI: 1.02-3.50, P-value: 0.043), with coefficients of 0.59, 0.75, and 0.63, respectively, all of which were statistically significant.</p><p><strong>Conclusion: </strong>This study's findings suggest that DAO is a significant risk factor for falls in elderly individuals. Moreover, the male gender appears to be protected against falls. In contrast, factors such as depression, higher risk based on the Time to \"Get Up and go\" test, and anemia are associated with elevated risk. These factors may be crucial in understanding the relationship between Dynapenic abdominal obesity and fall risk in the elderly. They can help stratify aged adults to prevent falls more efficiently.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"201"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compared to total serum testosterone, calculated free testosterone has a stronger association with lean mass, muscle strength, power, and physical function in older men.","authors":"Kristian Villars Lolck, Julian Alcazar, Rikke Stefan Kamper, Bryan Haddock, Peter Hovind, Flemming Dela, Charlotte Suetta","doi":"10.1007/s40520-025-03107-3","DOIUrl":"10.1007/s40520-025-03107-3","url":null,"abstract":"<p><strong>Background: </strong>Low serum testosterone concentrations have been associated with low muscle mass and strength in older men. However, the existing literature is inconclusive.</p><p><strong>Aim: </strong>To investigate the differences in the relationship between total and calculated free serum testosterone and muscle status, in young vs. old men.</p><p><strong>Methods: </strong>Body mass index (BMI), fat percentage, appendicular lean mass (ALM), percentage ALM (ALM%), skeletal muscle index (SMI), handgrip strength (HGS), leg extension power (LEP) and 30-s sit-to-stand performance (30-s STS) were measured in 557 healthy Danish men (326 younger (≤ 65 years) and 231 older (> 65 years)) aged 23-92 years. Total serum testosterone, sex hormone binding globulin and albumin were measured (ELISA) and subsequently, calculated free testosterone and free testosterone index (FTI) were computed. A general linear model examined the relationship between testosterone and individual muscle parameters, with age group-interaction, while a pooled effect model examined the relationship between testosterone and a compound of all muscle parameters, adjusted for age, BMI and fat percentage.</p><p><strong>Results: </strong>Total testosterone was negatively associated with 30-s STS in younger men, and positively associated with LEP in older men. Calculated free testosterone was positively associated with LEP in younger and older men, as well as SMI, ALM%, HGS and 30-s STS in older men. Calculated Free testosterone and FTI, but not total testosterone, were positively associated with the muscle compound in older men.</p><p><strong>Conclusion: </strong>The present data indicates that calculated free testosterone, compared to total testosterone, is more closely linked to muscle status and physical performance in older men.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"203"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of pain in older adults with chronic lung disease: analysis of the SHARE database.","authors":"Rodrigo Torres-Castro, Rodrigo Núñez-Cortés, Ana Clara Teixeira Fernandes, Sofía Dávila-Oña, Lilian Solis-Navarro, Joaquín Salazar-Méndez, Isabel Blanco, Luz Alejandra Lorca, Guilherme Augusto de Freitas Fregonezi, Vanessa Regiane Resqueti","doi":"10.1007/s40520-025-03066-9","DOIUrl":"10.1007/s40520-025-03066-9","url":null,"abstract":"<p><strong>Background: </strong>Chronic lung diseases (CLD) frequently present comorbidities. These include musculoskeletal conditions, most notably chronic pain.</p><p><strong>Aim: </strong>To determine whether the prevalence of pain in older adults with CLD is higher compared to the general population.</p><p><strong>Methods: </strong>The study is based on data from the 9th wave of the SHARE database, a representative survey of people aged 50 and over in 27 European countries and Israel. Age, sex, smoking status, education, and history of comorbidities were collected. A multivariable logistic regression analysis was performed to examine the associations of CLD with pain prevalence and severity.</p><p><strong>Results: </strong>A total of 4,129 cases with CLD and 62,608 cases without CLD were included in the analysis. The prevalence of pain was higher in people with CLD compared to people without CLD, with a proportion of 64.8% (95%CI: 63.3-66.2) versus 44.6% (95%CI: 44.2-44.9), respectively (p < 0.001). The location of pain in persons with CLD was greatest in the back region (37.6%, 95%CI: 36.1-39.1) and knees (29%, 95%CI: 27.6-30.4), followed by other joints (24.5%, 95% CI: 23.1-25.8), hips (19.8%, 95%CI: 18.6-21.1), other parts of the body but not joints (18.8%, 95%CI: 17.6-19.9), and all over (4.7%. 95%CI: 4.1-5.4).</p><p><strong>Conclusions: </strong>Older adults with CLD reported a variety of pain locations, with the back and knees being the most commonly affected regions. In addition, the prevalence and severity of pain were higher in older adults with CLD than in the general population.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"197"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}