Aging Clinical and Experimental Research最新文献

{"title":"Calf circumference was negatively associated with all-cause mortality among the Chinese centenarians: a prospective study with a 5-year follow-up","authors":"Zhigao Sun,&nbsp;Hengbo Zhang,&nbsp;Xiaofei Liu,&nbsp;Xiaobing Wang,&nbsp;Qiong Liu,&nbsp;Yali Zhao,&nbsp;Yan Nie,&nbsp;Dongzong Huang,&nbsp;Shihui Fu","doi":"10.1007/s40520-024-02850-3","DOIUrl":"10.1007/s40520-024-02850-3","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia is an aging-related disorder characterized by a loss of muscle mass and function. Calf circumference (CC) is a useful surrogate marker of muscle mass and function. This prospective study was designed to investigate the association between CC and all-cause mortality during a follow-up for 5 years in the Chinese centenarians.</p><h3>Methods</h3><p>The China Hainan Centenarian Cohort Study (CHCCS) is conducted in 18 cities and counties of Hainan, China.</p><h3>Results</h3><p>All 231 centenarians had a mean age of 103.03 years. Survival participants had a longer CC and were often living alone compared with others (<i>P</i>&lt;0.05 for all). Multivariate Cox regression models showed that CC was negatively associated with all-cause mortality (<i>P</i> &lt; 0.05 for all). Participants with a longer CC had a lower mortality risk compared with others [Exp(β): 0.918; 95%confidence interval: 0.863–0.977]. Participants with a longer CC had a lower mortality risk whether they were males or females and lived with family members or alone.</p><h3>Conclusion</h3><p>CC was negatively associated with all-cause mortality and could be an indicator of future mortality among the Chinese centenarians. Further researches should focus on preventing a decline in the CC in order to promote human longevity.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of accelerated aging in the association between depression and mortality risk: findings from NHANES","authors":"Cheng Xu,&nbsp;Jia-ni Wang,&nbsp;Zhen Song,&nbsp;Han-yu Deng,&nbsp;Chong-chao Li","doi":"10.1007/s40520-024-02854-z","DOIUrl":"10.1007/s40520-024-02854-z","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the association between depression, accelerated biological aging, and mortality risk, and to assess whether accelerated aging mediates the relationship between major depression and mortality risk.</p><h3>Methods</h3><p>A prospective cohort of 12,761 participants aged 20 years or older from the 2005–2010 cycle of the National Health and Nutrition Examination Survey (NHANES) was analyzed. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with scores of ≥ 10 indicating major depression. Accelerated biological aging was measured using phenotypic age acceleration (PhenoAgeAccel). Multivariable linear regression models and subgroup analyses were used to examine the association between depression and accelerated aging, while weighted multivariable Cox proportional hazards regression models and subgroup analyses assessed the impact of major depression on mortality risk. Mediation analysis was performed to assess whether PhenoAgeAccel mediated the relationship between major depression and mortality outcomes.</p><h3>Results</h3><p>Among the 12,761 adults, the weighted mean age was 46.6 years, with 48.8% being male, and 6.9% experiencing major depression. The results showed a positive association between major depression and PhenoAgeAccel (β: 0.61, 95% CI: 0.06–1.16). Over a median follow-up duration of 11.3 years (interquartile range: 9.9–13.1), major depression was associated with increased all-cause mortality (HR: 1.35, 95% CI: 1.13–1.62) and cardiovascular mortality (HR: 1.73, 95% CI: 1.18–2.54). However, the relationship with cancer mortality was not statistically significant after full adjustment for confounding factors. The mediation analysis further revealed that PhenoAgeAccel accounted for 10.32% and 5.12% of the associations between major depression and all-cause mortality, and cardiovascular mortality, respectively.</p><h3>Conclusion</h3><p>Depression is associated with accelerated aging and contributes to increased all-cause and cardiovascular mortality. Accelerated aging partially mediates the association between major depression and mortality risk. Our findings highlight the urgent need to incorporate mental health care into public health strategies to delay population aging and reduce mortality risk.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The negative association between sodium-driven nutrient pattern and telomere length: the chain mediating role of diastolic pressure and waist circumference","authors":"Baodi Xing,&nbsp;Jie Yu,&nbsp;Yiwen Liu,&nbsp;Shuli He,&nbsp;Qi Gao,&nbsp;Xinyue Chen,&nbsp;Fan Ping,&nbsp;Lingling Xu,&nbsp;Wei Li,&nbsp;Huabing Zhang,&nbsp;Yuxiu Li","doi":"10.1007/s40520-024-02852-1","DOIUrl":"10.1007/s40520-024-02852-1","url":null,"abstract":"<div><h3>Background</h3><p>Numerous single nutrients have been suggested to be linked with leukocyte telomere length (LTL). However, data on nutrient patterns (NPs), particularly in Chinese population, are scarce. This study aimed to examine the relationship between nutrient-based dietary patterns and LTL, and the potential role of metabolic factors.</p><h3>Methods</h3><p>Dietary data was obtained via 24-hour food recalls, and principal component analysis (PCA) was used to identify NPs. LTL was assessed using a real-time PCR assay. Multiple linear regression was conducted to determine the association between NPs and LTL. The potential role of metabolism among them was analyzed using mediation models.</p><h3>Results</h3><p>A total of 779 individuals from northern China were included in this cross-sectional analysis. Five main nutrient patterns were identified. Adjusted linear regression showed that the “high sodium” pattern was inversely associated with LTL (<i>B</i>=-0.481(-0.549, -0.413), <i>P</i> &lt; 0.05). The “high vitamin E-fat” pattern exhibited a positive correlation (<i>B</i> = 0.099(0.029, 0.170), <i>P</i> &lt; 0.05), whereas the “high vitamin A-vitamin B2” pattern was negatively correlated with LTL (<i>B</i>=-0.120(-0.183, -0.057), <i>P</i> &lt; 0.05), respectively. No significant associations were observed for the remaining nutrient patterns. The mediation model demonstrated that diastolic blood pressure and waist circumference could individually and collectively mediate the negative impact of the “high sodium” pattern on LTL (<i>B</i>_DBP=-0.0173(-0.0333, -0.0041), <i>B</i>_WC=-0.0075(-0.0186, -0.0004), <i>B</i>_joint=-0.0033 (-0.0072, -0.0006), all <i>P</i> &lt; 0.05). Moreover, glycosylated hemoglobin and non-high-density lipoprotein cholesterol mediate the relationship between the “high vitamin E-fat” pattern and LTL (<i>B</i>_HbA1c=0.0170(0.0010,0.0347), <i>B</i>_non-HDL-C= 0.0335 (0.0067, 0.0626), all <i>P</i> &lt; 0.05), respectively.</p><h3>Conclusions</h3><p>The “high sodium” and “high vitamin E-fat” nutrient patterns demonstrated negative and positive associations with LTL and metabolic indicators may play complex mediating roles in these relationships.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram for predicting pulmonary complications in elderly patients undergoing thoracic surgery","authors":"Jingjing Liu,&nbsp;Dinghao Xue,&nbsp;Long Wang,&nbsp;Yanxiang Li,&nbsp;Luyu Liu,&nbsp;Guosong Liao,&nbsp;Jiangbei Cao,&nbsp;Yanhong Liu,&nbsp;Jingsheng Lou,&nbsp;Hao Li,&nbsp;Yongbin Yang,&nbsp;Weidong Mi,&nbsp;Qiang Fu","doi":"10.1007/s40520-024-02844-1","DOIUrl":"10.1007/s40520-024-02844-1","url":null,"abstract":"<div><h3>Background</h3><p>Postoperative pulmonary complications (PPCs) remain a prevalent concern among elderly patients undergoing surgery, with a notably higher incidence observed in elderly patients undergoing thoracic surgery. This study aimed to develop a nomogram to predict the risk of PPCs in this population.</p><h3>Methods</h3><p>A total of 2963 elderly patients who underwent thoracic surgery were enrolled and randomly divided into a training cohort (80%, <i>n</i> = 2369) or a validation cohort (20%, <i>n</i> = 593). Univariate and multivariate logistic regression analyses were conducted to identify risk factors for PPCs, and a nomogram was developed based on the findings from the training cohort. The validation cohort was used to validate the model. The predictive accuracy of the model was evaluated by receiver operating characteristic (ROC) curve, area under ROC (AUC), calibration curve, and decision curve analysis (DCA).</p><h3>Results</h3><p>A total of 918 (31.0%) patients reported PPCs. Nine independent risk factors for PPCs were identified: preoperative presence of chronic obstructive pulmonary disease (COPD), elevated leukocyte count, higher partial pressure of arterial carbon dioxide (PaCO₂) level, surgical site, thoracotomy, intraoperative hypotension, blood loss &gt; 100 mL, surgery duration &gt; 180 min, and malignant tumor. The AUC value for the training cohort was 0.739 (95% <i>CI</i>: 0.719–0.762), and it was 0.703 for the validation cohort (95% <i>CI</i>: 0.657–0.749). The <i>P-</i>values for the Hosmer-Lemeshow test were 0.633 and 0.144 for the training and validation cohorts, respectively, indicating a notable calibration curve fit. The DCA curve indicated that the nomogram could be applied clinically if the risk threshold was between 12% and 84%, which was found to be between 8% and 82% in the validation cohort.</p><h3>Conclusion</h3><p>This study highlighted the pressing need for early detection of PPCs in elderly patients undergoing thoracic surgery. The nomogram exhibited promising predictive efficacy for PPCs in elderly patients undergoing thoracic surgery, enabling the identification of high-risk patients and consequently aiding in the implementation of preventive interventions.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study","authors":"Shan Ding,&nbsp;Fengling Yang,&nbsp;Pan Lai,&nbsp;Weiwen Jiang,&nbsp;Minze Chen,&nbsp;Yijun Ge,&nbsp;Liting Zhou,&nbsp;Shaozhuang Chen,&nbsp;Jiaqi Zhang,&nbsp;Yanrong Ye","doi":"10.1007/s40520-024-02851-2","DOIUrl":"10.1007/s40520-024-02851-2","url":null,"abstract":"<div><h3>Background</h3><p>The population of Aging cancer survivors in the United States has surged to over 16.9 million. Research on the relationship between statin usage and post-cancer survival rates remains limited.</p><h3>Aims</h3><p>This study aims to investigate the association between statin use and various causes of mortality among aging cancer survivors.</p><h3>Methods</h3><p>We analyzed NHANES data from 1999 to 2018, Statin usage, both hydrophilic and lipophilic, was derived from NHANES prescription records. We utilized Cox proportional hazards models to associate statin utilization with mortality, differentiating causes of death according to statin type and patterns of use.</p><h3>Results</h3><p>Within a cohort of 2,968 participants, statin usage was categorized into non-users (1,738), hydrophilic statin users (216), and lipophilic statin users (982). Compared to those who did not use statins, individuals prescribed hydrophilic statins did not show a reduced risk of all-cause mortality (adjusted hazard ratio [HR] 1.01; 95% confidence interval [CI] 0.72–1.41; <i>P</i> = 0.960), as outlined in Model 3. In contrast, the group receiving lipophilic statins exhibited a notable decrease in all-cause mortality risk (adjusted HR, 0.77; <i>P</i> = 0.003). Nonetheless, both hydrophilic and lipophilic statins were effective in diminishing the risk associated with cancer from its onset until death, with hydrophilic statins showing a greater level of efficacy.</p><h3>Discussion</h3><p>The potential of statins to reduce cancer-related mortality may provide avenues for targeted clinical interventions and management strategies.</p><h3>Conclusions</h3><p>Our study reveals that the use of lipophilic statins is significantly associated with lower all-cause and cancer-cause mortality risks among aging cancer survivors.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dynapenic abdominal obesity and arthritis among the middle-aged and older Chinese: a longitudinal study","authors":"Shengliang Zhou,&nbsp;Naijia Luo,&nbsp;Haibo Si,&nbsp;Wacili Da,&nbsp;Yuan Liu,&nbsp;Limin Wu,&nbsp;Mingyang Li,&nbsp;Bin Shen","doi":"10.1007/s40520-024-02847-y","DOIUrl":"10.1007/s40520-024-02847-y","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to assess the longitudinal association between dynapenic abdominal obesity and new-onset arthritis among the middle-aged and older Chinese population.</p><h3>Methods</h3><p>We included 6863 participants from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS). Dynapenia was defined as handgrip strength &lt; 28 kg for males, and &lt; 18 kg for females. Abdominal obesity was defined as a waist circumference ≥ 90 cm for males and ≥ 85 cm for females. Based on the definitions, all participants were divided into four groups: no dynapenia and no abdominal obesity (ND/NAO), abdominal obesity alone (ND/AO), dynapenia alone (D/NAO), and dynapenia and abdominal obesity (D/AO). The association between dynapenic abdominal obesity and new-onset arthritis was assessed by sex using the Poisson regression models.</p><h3>Results</h3><p>After a four-year follow-up, 1272 (18.53%) participants reported new-onset arthritis. Those in the D/AO group had a significantly increased risk of new-onset arthritis compared to those in the ND/NAO group (adjusted relative risk (RR): 1.34, 95% confidence interval (CI): 1.01–1.77). In females, the ND/AO (RR: 1.21, 95% CI: 1.03–1.43) and D/AO (RR: 1.39, 95% CI: 1.01–1.93) groups were associated with a higher risk of arthritis. This significant association was not observed in males.</p><h3>Conclusions</h3><p>Our results indicated that the combined effect of dynapenia and abdominal obesity significantly increased the risk of new-onset arthritis in females, but this association was not observed in males.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms","authors":"Antonio Martocchia,&nbsp;Manuela Stefanelli,&nbsp;Maurizio Gallucci,&nbsp;Marianna Noale,&nbsp;Stefania Maggi,&nbsp;Maurizio Cassol,&nbsp;Demetrio Postacchini,&nbsp;Antonella Proietti,&nbsp;Mario Barbagallo,&nbsp;Ligia J. Dominguez,&nbsp;Claudio Ferri,&nbsp;Giovambattista Desideri,&nbsp;Lavinia Toussan,&nbsp;Francesca Pastore,&nbsp;Giulia M. Falaschi,&nbsp;Giuseppe Paolisso,&nbsp;Paolo Falaschi,&nbsp;The AGICO Investigators","doi":"10.1007/s40520-024-02849-w","DOIUrl":"10.1007/s40520-024-02849-w","url":null,"abstract":"<div><h3>Background</h3><p>The mechanisms at the basis of depression are still matter of debate, but several studies in the literature suggest common pathways with dementia (genetic predispositions, metabolic and inflammatory mechanisms, neuropathological changes) and other geriatric syndromes.</p><h3>Aims</h3><p>To evaluate the role of cortisol (as marker of the HPA, hypothalamus–pituitary–adrenal axis hyperactivity) in elderly subjects with depressive symptoms (by the means of the AGICO, AGIng and COrtisol, study), in relationship to the presence of the major geriatric syndromes.</p><h3>Methods</h3><p>The AGICO study enrolled patients from ten Geriatric Units in Italy. Every subject received a comprehensive geriatric assessment or CGA (including the Mini Mental State Examination or MMSE, Geriatric Depression Scale or GDS and Cornell Scale for Depression in Dementia or CSDD), the neurological examination (with a computed tomography scan or magnetic resonance imaging of the brain), the assessment of the metabolic syndrome (MetS), the evaluation of the cortisol activity by two consecutive urine collections (diurnal and nocturnal), a CGA-derived frailty index (FI) and a modified measure of allostatic load (AL).</p><h3>Results</h3><p>The MMSE scores were significantly and inversely related to the values of GDS (p &lt; 0.001) and CSDD (p &lt; 0.05), respectively. The patients with depressive symptoms (GDS/CSDD &gt; 8) showed significantly increased disability, MetS, inflammation, FI and AL and significantly reduced MMSE and renal function.</p><p>The diurnal and nocturnal urinary cortisol levels in the patients with depressive symptoms (GDS/CSDD &gt; 8) were higher with respects to controls (p &lt; 0.05 for nocturnal difference).</p><h3>Discussion</h3><p>The AGICO study showed that the stress response is activated in the patients with depression.</p><h3>Conclusion</h3><p>The depression in elderly patient should be reconsidered as a systemic disease, with coexisting major geriatric syndromes (disability, dementia, frailty) and combined pathogenetic mechanisms (metabolic syndrome, impaired renal function, low-grade inflammation, and allostatic load). Cortisol confirmed its role as principal mediator of the aging process in both dementia and metabolic syndrome.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which stakeholders should be addressed to promote Geriatric Medicine among healthcare professionals, educationalists and policy-makers in European countries? – the PROGRAMMING COST 21,122 action experience","authors":"Sumru Savas,&nbsp;Nilufer Demiral Yilmaz,&nbsp;Marina Kotsani,&nbsp;Karolina Piotrowicz,&nbsp;Sofia Duque","doi":"10.1007/s40520-024-02841-4","DOIUrl":"10.1007/s40520-024-02841-4","url":null,"abstract":"<div><h3>Background</h3><p>Geriatric Medicine (GM), concerned with well-being and health of older adults, can play a crucial role in the alignment of healthcare systems to the needs of the aged populations. However, countries have varying GM development backgrounds. The goal of PROGRAMMING- COST 21,122 Action is to propose the content of education and training activities in GM for healthcare professionals across various clinical settings, adapted to local context, needs, and assets. Defining relevant stakeholders and addressing them on both an international as well as a country-specific level is crucial for this purpose. In this paper we are describing the methods used in the PROGRAMMING Action 21,122 to map the different categories of stakeholders to be engaged in the Action.</p><h3>Methods</h3><p>Through conceptualizing a model for stakeholders by literature research, and online discussion group meetings, a synthesis for the potential stakeholders was defined as a template, and pilot applications were requested from participant countries.</p><h3>Results</h3><p>There were 24 members from 14 countries (6 males/18 females) of multidisciplinary professions involved in this study. A model for the list of stakeholders to be addressed was developed and, after seven online discussion meetings, a consensus framework was provided. Invited countries completed the templates to pilot such operationalization.</p><h3>Conclusion</h3><p>Our framework of stakeholders will support the research coordination and capacity-building objectives of PROGRAMMING, including the participation into the assessment of educational needs of healthcare professionals. Identified stakeholders will also be mobilized for purposes of dissemination and maximization of the Action’s impact. By defining and mapping multidisciplinary stakeholders involved in older people’s care specific to countries, particularly where GM is still emerging, GM tailored educational activities will be facilitated and optimally targeted.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted vs. laparoscopic right hemicolectomy in octogenarians and nonagenarians: an analysis of the US nationwide inpatient sample 2005–2018","authors":"Chien-Chang Lu,&nbsp;Chi-Tung Lu,&nbsp;Kai-Yen Chang,&nbsp;Wang Chun-Li,&nbsp;Chien-Ying Wu","doi":"10.1007/s40520-024-02833-4","DOIUrl":"10.1007/s40520-024-02833-4","url":null,"abstract":"<div><h3>Background</h3><p>Colorectal cancer (CRC) is a significant health concern, particularly among older adults. Outcomes between laparoscopic and robot-assisted surgeries for right-sided colon cancers in the oldest old population have yet to be evaluated despite increased use of these surgeries.</p><h3>Aim</h3><p>This study aimed to compare clinical outcomes after robot-assisted right hemicolectomy (RARH) versus laparoscopic right hemicolectomy (LRH) in octogenarian and nonagenarian patients.</p><h3>Methods</h3><p>This population-based, retrospective and observational study analyzed the data of adults ≥ 80 years old diagnosed with right-side colon cancer who received RARH or LRH. All data were extracted from the US National Inpatient Sample (NIS) database 2005–2018. Associations between type of surgery and in-hospital outcomes were determined using univariate and multivariable logistic regression and linear regression analysis.</p><h3>Results</h3><p>Data of 7,550 patients (representing 37,126 hospitalized patients in the U.S.) were analyzed. Mean age of the study population was 84.8 years, 61.4% were females, and 79.1% were non-smokers. After adjusting for relevant confounders, regression analysis showed that patients undergoing RARH had a significantly shorter LOS (adjusted Beta (aBeta), -0.24, 95% CI: -0.32, -0.15) but greater total hospital costs (aBeta, 26.54, 95% CI: 24.64, 28.44) than patients undergoing LRH. No significant differences in mortality, perioperative complications, and risk of unfavorable discharge were observed between the two procedures (<i>p</i> &gt; 0.05). Stratified analyses by frailty status revealed consistent results.</p><h3>Conclusions</h3><p>RARH is associated with a significantly shorter LOS but higher total hospital costs than LRH among octogenarians and nonagenarians. Other short-term outcomes for this population are similar between the two procedures, including in-hospital mortality, perioperative complications, and unfavorable discharge. These findings also apply to frail patients.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Prevention at home in older persons with (pre-)frailty: analysis of participants’ recruitment and characteristics of the randomized controlled PromeTheus trial","authors":"Tim Fleiner,&nbsp;Corinna Nerz,&nbsp;Michael Denkinger,&nbsp;Jürgen M. Bauer,&nbsp;Christian Grüneberg,&nbsp;Judith Dams,&nbsp;Martina Schäufele,&nbsp;Gisela Büchele,&nbsp;PromeTheus Study Group,&nbsp;Kilian Rapp,&nbsp;Christian Werner","doi":"10.1007/s40520-024-02837-0","DOIUrl":"10.1007/s40520-024-02837-0","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}