Aging Clinical and Experimental Research最新文献

{"title":"Sarcopenia-related traits and risk of falls in older adults: results from meta-analysis of cohort studies and Mendelian randomization analyses","authors":"Haohan Yang,&nbsp;Yu Jiang,&nbsp;Dingfa Liang,&nbsp;Chang Yang,&nbsp;Kaihua Qin,&nbsp;Yong Xie,&nbsp;Licheng Zhang,&nbsp;Peifu Tang,&nbsp;Xiang Cui,&nbsp;Houchen Lyu","doi":"10.1007/s40520-025-02997-7","DOIUrl":"10.1007/s40520-025-02997-7","url":null,"abstract":"<div><h3>Background</h3><p>Observational studies examining sarcopenia-related traits and fall risk remain controversial. Herein, we conducted meta-analyses of cohort studies triangulated with Mendelian randomization (MR) analyses to examine the potential causality between sarcopenia-related traits and risk of falls in older adults.</p><h3>Methods</h3><p>Literature search across PubMed, Embase, and Cochrane Library was performed from inception to February 2023 to identify cohort studies examining sarcopenia-related traits (including hand strength, appendicular lean mass, and walking speed) and falls. We assessed the association between these traits and fall risk using random-effects models to calculate pooled odds ratios (OR) and 95% confidence intervals (CIs). MR analyses were conducted using summary statistics derived from the UK Biobank consortium for sarcopenia-related traits and FinnGen consortium for falls. The inverse-variance weighted method was used as primary analysis.</p><h3>Results</h3><p>Our meta-analysis included 34 cohort studies. The combined analysis of sarcopenia-related traits revealed a 33% reduced fall risk with each unit increase in walking speed (OR 0.67, 95% CI 0.54–0.84) and a 2% decrease with each unit increase in hand strength (OR 0.98, 95% CI 0.97–0.99). However, appendicular lean mass had no significant effect on falls. In the MR analyses, only walking speed was causally associated with falls (OR 0.64, 95% CI 0.48–0.84). Hand strength and appendicular lean mass showed no statistically significant causal effect on falls.</p><h3>Conclusion</h3><p>Evidence from meta-analysis and MR suggests a strong association between walking speed and fall risk in older adults. However, the relationship between hand strength, appendicular lean mass, and falls has not yet been established.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02997-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable sarcopenia and depressive symptoms in community-dwelling older adults: exploring the role of frailty and comorbidities","authors":"Emanuele Rocco Villani,&nbsp;Andrea Salerno,&nbsp;Federico Triolo,&nbsp;Laura Franza,&nbsp;Giulia Vaccari,&nbsp;Barbara Manni,&nbsp;Antonella Rita Vaccina,&nbsp;Lucia Bergamini,&nbsp;Vanda Menon,&nbsp;Davide Zaccherini,&nbsp;Andrea Fabbo","doi":"10.1007/s40520-025-03005-8","DOIUrl":"10.1007/s40520-025-03005-8","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia is a syndrome characterized by the loss of skeletal muscle associated with reduced physical strength/performance and could be correlated with depression, that is the most frequent cause of emotional distress in old age and can reduce the quality of life of the older adults.</p><h3>Aim</h3><p>The aim of the present study is to evaluate the association between probable sarcopenia and depressive symptoms in older adults, and the impact of comorbidity and frailty on this association.</p><h3>Methods</h3><p>This cross-sectional study included community-dwelling older adults at their first geriatric evaluation. Probable sarcopenia was screened according to SARC-F. Clinically significant depressive symptoms (CSDS) were assessed according to the 5-items geriatric depression scale (GDS.) Frailty was determined through the CHSA-clinical frailty scale (CFS). Comorbidity burden was scored through the Cumulative Illness Rating Scale-Geriatric (CIRS-CI).</p><h3>Results</h3><p>We included 238 participants with a mean age of 82.4 (± 6.9) years of age, 152 (63.6%) participants were females. Probable sarcopenia was diagnosed in 131 (55.0%) participants, while CSDS were present in 186 (78.2%) participants. In the multiadjusted model, probable sarcopenia was associated with a higher likelihood of CSDS (OR 2.70, 95% CI 1.03–6.12). No significant interaction of frailty and CIRS were found on the association between probable sarcopenia and CSDS.</p><h3>Conclusions</h3><p>Sarcopenia and depressive symptomatology are highly co-occurring in geriatric patients, and this association may be independent of frailty and comordibity burden.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03005-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of elderly myocarditis (1992–2021) and projections of future disease burden trends","authors":"Weichun Wang,&nbsp;Xiaofeng Chen","doi":"10.1007/s40520-025-02979-9","DOIUrl":"10.1007/s40520-025-02979-9","url":null,"abstract":"<div><h3>Objective</h3><p>Geriatric myocarditis represents a significant public health concern, directly influencing overall health and potentially leading to various cardiac diseases. This study seeks to quantify the burden of geriatric myocarditis over three decades (1992–2021) and provide forecasts for future disease burden.</p><h3>Methods</h3><p>Data on geriatric myocarditis from 1992 to 2021 was obtained from the Global Burden of Disease study, offering insights into the incidence of the condition, categorized by gender. The Joinpoint regression model was utilized to identify shifts in epidemiological trends, while decomposition analysis helped identify the underlying factors contributing to these trends. To project future incidence, deaths and DALYs (Disability-Adjusted Life Years), the Norpred and Bayesian Age-Period-Cohort (BAPC) models were employed.</p><h3>Results</h3><p>In 2021, the global ASIR (per 100,000) of elderly myocarditis was 47.57 (27.52–73.08), with 505,147 (292,319–774,561) cases. Age-standardized deaths(per 100,000) were 2.07 (1.55–2.51), totaling 20,718 (15,525–25,085) deaths, and age-standardized DALYs(per 100,000) were 29.77 (22.60–35.81), with 308,101 (234,226–370,674) DALYs. Greenland, Canada, and Austria had the highest ASIR(per 100,000), while Romania, Kazakhstan, and Croatia had the highest age-standardized deaths(per 100,000), and Romania, Kazakhstan, and Guyana had the highest age-standardized DALYs(per 100,000). Joinpoint Regression analysis revealed a recent upward trend in global incidence after a previous decline, consistent across genders and SDI regions. Deaths and DALYs showed declining trends globally, though male deaths recently increased. Decomposition analysis identified population growth and aging as key drivers of increased cases, deaths, and DALYs. Based on the nordpred model, by 2045, the global ASIR(per 100,000) is predicted to be 47.27, with 1,005,593 cases, age-standardized deaths(per 100,000) of 2.02, totaling 48,501 deaths, and age-standardized DALYs(per 100,000) of 26.21, with 595,694 DALYs. The BAPC model predicts a global ASIR(per 100,000) of 51.82, with 1,091,195 cases, age-standardized deaths(per 100,000) of 3.67, totaling 87,145 deaths, and age-standardized DALYs(per 100,000) of 49.09, with 1,084,738 DALYs.</p><h3>Conclusion</h3><p>As of 2021, the ASIR(per 100,000) of myocarditis in the elderly population showed a decline compared to 1992; however, a recent upward trend has been identified. Considering ongoing population growth, the number of myocarditis cases among the elderly is anticipated to increase.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02979-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characteristics of older adults with type 2 diabetes mellitus living in French Caribbean nursing homes: results from the baseline KASEHPAD study","authors":"Maturin Tabué-Teguo,&nbsp;Nadine Simo,&nbsp;Christine Rambhojan,&nbsp;Laurys Letchimy,&nbsp;Michel Bonnet,&nbsp;Fritz-Line Vélayoudom,&nbsp;Denis Boucaud-Maitre","doi":"10.1007/s40520-025-03008-5","DOIUrl":"10.1007/s40520-025-03008-5","url":null,"abstract":"<div><h3>Background</h3><p>The management of older adults with type 2 diabetes mellitus (T2DM) has not been previously assessed in nursing homes within the Caribbean region.</p><h3>Aims</h3><p>To investigate the prevalence of T2DM among residents of French Caribbean nursing homes and to characterize their health and functional status.</p><h3>Methods</h3><p>This cross-sectional study is based on baseline screening data from the KASEHPAD (Karukera Study of Ageing in Nursing Homes) cohort. Clinical characteristics and standard geriatric parameters were systematically collected and analyzed. Hemoglobin A1c (HbA1c) levels of older adults with diabetes were retrospectively extracted from patient records.</p><h3>Results</h3><p>A total of 332 participants aged 60 years or older were recruited from six nursing homes between September 2020 and November 2022. The prevalence of T2DM among residents was 28.3% (95% CI: 23.5–33.2). Among older adults with T2DM, 85.1% had hypertension, 17.1% had heart failure, and 24.1% had a history of stroke. The mean HbA1c level was 7.32 ± 1.5%. Of the 35 individuals (42.7%) with HbA1c &lt; 7%, 19 (54.3%) were receiving antidiabetic medications. Multivariate analysis identified HbA1c as the sole factor significantly associated with antidiabetic medication use (OR: 1.76, 95% CI: 1.12–3.04).</p><h3>Discussion</h3><p>Older adults with T2DM residing in French Caribbean nursing homes exhibit a high prevalence of cardiovascular risk factors and are at risk of overtreatment. The management of T2DM in this population appears to be driven primarily by blood glucose levels.</p><h3>Conclusion</h3><p>As the prevalence of older adults with T2DM is expected to rise in the Caribbean region, this trend will present significant challenges in delivering tailored care within future nursing home settings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03008-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant intervention to possibly delay disease progression and frailty in elderly idiopathic pulmonary fibrosis patients: a clinical trial","authors":"Hongyan Ren,&nbsp;Zheng Wang,&nbsp;Yafen Jiang,&nbsp;Qing Mu,&nbsp;Yaxin Li,&nbsp;Jing Wang,&nbsp;Tiantian Cui,&nbsp;Qijie Sun,&nbsp;Xiaojv Zhang","doi":"10.1007/s40520-025-03009-4","DOIUrl":"10.1007/s40520-025-03009-4","url":null,"abstract":"<div><h3>Background</h3><p>Idiopathic pulmonary fibrosis (IPF) is more likely to occur in the elderly population, and these patients often become depressed. It has been recognized that psychological disorders are not conducive to the control of many diseases. Thus, this study aims to determine whether alleviating depression can delay the progression of IPF and frailty in elderly patients with IPF.</p><h3>Methods</h3><p>IPF patients over 60 years old were included in the study. None had a prior history of psychological disorders. All developed depression after being diagnosed with IPF. During the 12-month follow-up, some patients received anti-depression interventions and the rest didn’t. Depression, IPF, frailty and peripheral inflammation at baseline and after follow-up were evaluated by indicators and scales such as BDI-II, FVC %pred, 6MWT, mMRC, CFS, TFI, SGRQ, K-BILD, IL-6, and TNF-α. Multivariate logistic regression was employed for data analysis.</p><h3>Results</h3><p>There were 213 elderly patients with IPF. Among the 89 patients who received anti-depression interventions, the above-mentioned indicators and scales did not deteriorate during the follow-up period (P &gt; 0.05). Among the remaining 124 patients, the FVC %pred, and 6MWT levels decreased, and the mMRC grade, CFS, TFI, SGRQ and K-BILD scores, and peripheral IL-6 and TNF-α levels increased during the follow-up period (P &lt; 0.05).</p><h3>Discussion</h3><p>Compared with non-intervened IPF patients, those receiving anti-depression interventions seemed to maintain a certain stability in IPF, frailty, and peripheral inflammation over a period.</p><h3>Conclusion</h3><p>Improving depression may help delay the deterioration of patients' IPF and frailty at certain stages.</p><p>Trial registration: Registration on UMIN-CTR. Registration number: UMIN000057161. Date of registration: February 27th, 2025.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03009-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anemia-related mortality trends in US older subjects, 1999 to 2019","authors":"Marco Zuin,&nbsp;Luigi Ferrucci,&nbsp;Giovanni Zuliani","doi":"10.1007/s40520-025-02982-0","DOIUrl":"10.1007/s40520-025-02982-0","url":null,"abstract":"<div><h3>Background</h3><p>Previous investigations showed that the prevalence of iron deficiency is increasing in United States (US). However, data regarding iron deficiency anemia-related mortality trends are lacking. We assess the trends in iron deficiency anemia-related mortality in US adults aged 65 years or older over the last two decades.</p><h3>Methods</h3><p>Iron-deficiency anemia-related deaths were ascertained using ICD-10 codes in the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2019. Age-adjusted mortality rates (AAMRs) were assessed using the Joinpoint regression modelling and expressed as estimated average annual percentage change (AAPC) and annual percent change (APC) with relative 95% confidence interval (95% CI), stratified by level of urbanization, sex, age, and race.</p><h3>Results</h3><p>Between 1999 and 2019, 30,540 US subjects aged ≥ 65 years old (11,986 men and 18,554 women) equating to 77.8 deaths per 100,000 or 27.9 deaths per week, had iron deficiency anemia listed as a cause of death. The AAMR remained stable from 1999 to 2013 [APC: -0.3, (95%CI: -0.9 to 0.1, <i>p</i> = 0.11)] and then sharply increased from 2013 to 2019 [APC: +9.7% (95%CI: 7.8 to 11.6), <i>p</i> &lt; 0.0001) without differences in sex, race, ethnicity or level of urbanization. The higher AAMRs were clustered in the Midwest [4.29 per 100,000 (95% CI: 4.20 to 4.38)] and in the South [3.35 per 100,000, 95% CI: 3.28 to 3.35)].</p><h3>Conclusions</h3><p>Over the last two decades the iron deficiency anemia-related mortality trends increased among US older subjects, without differences by sex, race, ethnicity or urbanicity.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02982-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health outcomes of sarcopenia: a consensus report by the outcome working group of the Global Leadership Initiative in Sarcopenia (GLIS)","authors":"Charlotte Beaudart,&nbsp;Julian Alcazar,&nbsp;Ivan Aprahamian,&nbsp;John A. Batsis,&nbsp;Yosuke Yamada,&nbsp;Carla M. Prado,&nbsp;Jean-Yves Reginster,&nbsp;Dolores Sanchez-Rodriguez,&nbsp;Wee Shiong Lim,&nbsp;Marc Sim,&nbsp;Stephan von Haehling,&nbsp;Jean Woo,&nbsp;Gustavo Duque,&nbsp;The Global Leadership Initiative in Sarcopenia (GLIS) group","doi":"10.1007/s40520-025-02995-9","DOIUrl":"10.1007/s40520-025-02995-9","url":null,"abstract":"<div><p>The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the GLIS has organized three different working groups (WGs), with the WG on outcomes of sarcopenia focusing on reporting its health outcomes to be measured in clinical practice once a diagnosis has been established. This includes sarcopenia definitions that better predict health outcomes, the preferred tools for measuring these outcomes, and the cutoffs defining normal and abnormal values. The present article synthesizes discussions and conclusions from this WG, composed of 13 key opinion leaders from different continents worldwide. Results rely on systematic reviews, meta-analyses, and relevant cohort studies in the field. With a high level of evidence, sarcopenia is significantly associated with a reduced quality of life, a higher risk of falls and fractures and a higher risk of mortality. Sarcopenia has been moderately associated with a higher risk of reduced instrumental activities of daily living (IADL). However, the GLIS WG found only inconclusive level of evidence to support associations between sarcopenia and higher risks of hospitalization, nursing home admission, mobility impairments, and reduced basic activities of daily living (ADL). This limitation underscores the scarcity of longitudinal studies, highlighting a barrier to understanding its progression and implications over time.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02995-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting countries to ensure the continuum of integrated care for older people","authors":"Yuka Sumi,&nbsp;Rachel Albone,&nbsp;Matteo Cesari","doi":"10.1007/s40520-025-02970-4","DOIUrl":"10.1007/s40520-025-02970-4","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02970-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts","authors":"Nazario Carrabba,&nbsp;Mattia Alexis Amico,&nbsp;Gherardo Busi,&nbsp;Matteo Vannini,&nbsp;Filippo Bruscoli,&nbsp;Salvatore Fortunato,&nbsp;Luciano Arcari,&nbsp;Emilio Di Lorenzo,&nbsp;Giampaolo Luzi,&nbsp;Francesco Clemenza,&nbsp;Francesco Amico,&nbsp;Giuseppe Pes,&nbsp;Marco Merlo,&nbsp;Gianfranco Sinagra,&nbsp;Giovambattista Desideri,&nbsp;Francesco Vetta,&nbsp;Alessandro Mugelli,&nbsp;Niccolo Marchionni,&nbsp;Alessandro Boccanelli,&nbsp;the PREVASC Working Group, Italian Society of Geriatrica Cardiology (SICGe)","doi":"10.1007/s40520-025-02937-5","DOIUrl":"10.1007/s40520-025-02937-5","url":null,"abstract":"<div><h3>Aims</h3><p>Valvular heart disease (VHD) is the third leading cause of cardiovascular morbidity, with its incidence and public health impact projected to increase significantly. This study adopts a novel perspective, focusing on elderly individuals residing in rural areas, highlighting the unique dynamics of small-town settings.</p><h3>Methods</h3><p>This multicenter, observational study was conducted from May 2022 to September 2023, under the coordination of the AOU Careggi Echo Core-Lab, which managed the entire screening program. In 10 small Italian villages, each municipality facilitated the enrollment of asymptomatic individuals aged ≥ 65 years, with no prior VHD history, through voluntary participation. Participants were grouped into three age categories (65–69, 70–74, and ≥ 75 years) and underwent a thorough evaluation, including a Quality of Life (QoL) questionnaire and comprehensive echocardiographic assessment focusing on VHD detection and grading.</p><h3>Results</h3><p>Among 1,113 participants, the prevalence and severity of VHD showed a significant increase with age (<i>p</i> &lt; 0.0001). Remarkably, 94% of individuals aged ≥ 75 years had at least one valvular defect, with 22.5% presenting moderate or severe valvulopathy, including a prevalence of 4.8% for moderate or severe aortic valve stenosis and 7.5% for mitral regurgitation. Right-sided valvulopathies followed a similar trend, affecting 71.9% of elderly participants. QoL evaluations revealed a generally positive perceived health status, with a mean score of 77 ± 16.</p><h3>Conclusions</h3><p>Our registry highlights that the prevalence of VHD in asymptomatic individuals over 65 years living in small Italian communities is substantial, increases with age, and is predominantly degenerative in etiology. Notably, most individuals with undiagnosed VHD perceived themselves as healthy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02937-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and waist circumference as key determinants of postoperative thrombosis and squatting recovery after unicompartmental knee arthroplasty","authors":"Xuyang Cao,&nbsp;Mengsha Wang,&nbsp;Zizi Zhao,&nbsp;Taotao Kong","doi":"10.1007/s40520-025-02974-0","DOIUrl":"10.1007/s40520-025-02974-0","url":null,"abstract":"<div><h3>Background</h3><p>Thrombosis is a common postoperative complication after unicompartmental knee arthroplasty (UKA), and the ability to squat is an important functional outcome reflecting recovery of knee function. This study aimed to investigate the factors influencing postoperative thrombosis as well as the ability to squat within 1 year after UKA.</p><h3>Methods</h3><p>Data from UKA patients were retrospectively analyzed and grouped based on the occurrence of thrombosis (including deep vein thrombosis and superficial vein thrombosis) and the ability to squat within 1 year. Factors affecting thrombosis and squatting were compared and analyzed using multifactorial logistic regression.</p><h3>Results</h3><p>Univariate analysis revealed that age (<i>P</i> = 0.014), pre-operative haemoglobin (<i>P</i> = 0.044), and gender (<i>P</i> = 0.047) were associated with thrombosis, while multifactorial analysis found age (<i>P</i> = 0.024) as the key factor. Regarding squatting ability, univariate analysis identified age (<i>P</i> = 0.018), body weight (<i>P</i> = 0.001), BMI (<i>P</i> = 0.001), waist circumference (<i>P</i> &lt; 0.001), pre-operative VAS score (<i>P</i> = 0.002), and family living conditions (<i>P</i> = 0.019) as influencing factors, with multifactorial analysis identifying waist circumference (<i>P</i> = 0.002) as a significant factor.</p><h3>Conclusions</h3><p>Older age increases the likelihood of thrombosis after UKA. Additionally, a larger waist circumference decreases the likelihood of squatting within 1 year after surgery.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02974-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}