Aging Clinical and Experimental Research最新文献

{"title":"3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.","authors":"Sabine Schluessel, Benedikt Mueller, Michael Drey, Olivia Tausendfreund, Michaela Rippl, Linda Deissler, Sebastian Martini, Ralf Schmidmaier, Sophia Stoecklein, Michael Ingrisch","doi":"10.1007/s40520-025-03206-1","DOIUrl":"https://doi.org/10.1007/s40520-025-03206-1","url":null,"abstract":"<p><strong>Background: </strong>In order to identify patients with sarcopenia, the use of routine imaging could provide valuable support. One of the most common radiological examinations, especially in geriatric inpatient care, is CT thoracic imaging. Therefore, it would be desirable to generate muscle volumes from these images using automated body composition analysis. The aim of this study is to determine the muscle volumes of geriatric patients and to investigate to what extent these correspond to the values of one of the current reference standards in diagnosing sarcopenia, the Dual-energy X-ray Absorptiometry (DXA) measurement.</p><p><strong>Methods: </strong>This retrospective study included 208 geriatric patients (mean age: 81 ± 7 years, 53.4% women) treated at the Acute Geriatric Ward at LMU University Hospital between 2015 and 2022. All participants underwent DXA measurement to assess appendicular skeletal muscle mass (ASM). Pretrained deep learning models were used to analyze body composition from routinely obtained thoracic CT images. Correlations between CT and DXA data were calculated using Pearson correlations, taking into account different normalization variants (height², weight, bone volume and total volume). Multivariable linear regression analysis was performed to predict DXA-measured ASM.</p><p><strong>Results: </strong>Women and men differed significantly in bone volume, muscle volume, and intramuscular fat. A reliable correlation was found between muscle volume from CT-thorax analysis and ASM from DXA, especially for absolute muscle volume (r = 0.669, p < 0.001) and muscle volume normalized to height² (r = 0.529, p < 0.001). In regression analysis, CT muscle volume alone explained 44.5% of the variance in ASM (R² = 0.445, p < 0.001). When body weight was added, the model's explanatory power increased significantly to 68.9% (R² = 0.689, p < 0.001). The fully adjusted model, which included height, age, and sex, further improved the explained variance only slightly (R² = 0.713, p < 0.001). Among all predictors, body weight showed the strongest effect, followed by CT muscle volume, while sex had no significant influence.</p><p><strong>Conclusion: </strong>The results show that the automated analysis of CT thoracic scans is a useful method for determining muscle volume and agrees well with the DXA analysis. Furthermore, the predictive value of CT muscle volume is significantly enhanced in combination with anthropometric parameters, particularly body weight. Further prospective studies are required to validate the findings and refine CT-based sarcopenia diagnostics.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"296"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet and Cantonese cuisine for human health: report from a Sino-Italian bilateral meeting","authors":"Stefania Maggi,&nbsp;Fiona Ecarnot,&nbsp;Vincenza Gianfredi,&nbsp;Daniele Nucci,&nbsp;Nicola Veronese,&nbsp;Liang Lei,&nbsp;Min Hu,&nbsp;Christelle Avart,&nbsp;Antonio Capurso,&nbsp;Limin Chen,&nbsp;Fatima Hachem,&nbsp;Haibin Yang,&nbsp;Antonio F. Logrieco,&nbsp;Massimiliano Magli,&nbsp;Quansheng Mai,&nbsp;Federico Palla,&nbsp;Stefano Predieri,&nbsp;René Rizzoli,&nbsp;Domenico Rogoli,&nbsp;Angelo Santino,&nbsp;Marco Silano,&nbsp;Milena Simeoni,&nbsp;Antonia Trichopoulou,&nbsp;Roberto Volpe,&nbsp;Yong Wang,&nbsp;Juhua Wu,&nbsp;Ma Xiaohui,&nbsp;Xiaoyan Chen,&nbsp;Xuhui Zhang,&nbsp;Li Yujie,&nbsp;Michela Zanetti,&nbsp;Giorgio Picci","doi":"10.1007/s40520-025-03199-x","DOIUrl":"10.1007/s40520-025-03199-x","url":null,"abstract":"<div><p>This article explores the traditional Mediterranean and Cantonese diets through historical, cultural, and scientific lenses. Drawing from expert presentations delivered during a multi-day international symposium, we examine the culinary practices, nutritional components, and health implications of both dietary traditions. The comparative analysis addresses cardiovascular and metabolic health, cancer prevention, functional foods, public policy, and the emerging role of traditional foods in modern preventive medicine. By analyzing the synergy between dietary elements and lifestyle factors, we highlight how these long-standing traditions can inform contemporary strategies for health promotion and chronic disease prevention.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03199-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal maximal tubular reabsorption of phosphate as a novel biomarker of physical dysfunction in older adults","authors":"Mengzhen Sun,&nbsp;Shixuan Zhang,&nbsp;Hui Zhang,&nbsp;Na Zhang,&nbsp;Weicheng Wu,&nbsp;Yuanfei Cao,&nbsp;Mengjing Wang,&nbsp;Jing Chen,&nbsp;Xiaoyan Jiang,&nbsp;Xuehui Sun,&nbsp;Xiaofeng Wang,&nbsp;Qi Zhang","doi":"10.1007/s40520-025-03198-y","DOIUrl":"10.1007/s40520-025-03198-y","url":null,"abstract":"<p>Abnormal TmP/GFR as a novel biomarker of physical dysfunction in older adults. Abnormal TmP/GFR facilitates the early detection of physical dysfunction, enabling the prevention of severe adverse outcomes. Future studies targeting improvements in physical function can use measurements of TmP/GFR biomarkers as intermediate outcomes.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03198-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypharmacy appropriateness in Italian Long-Term Care Facilities: the nationwide prescription day point survey","authors":"Alba Malara,&nbsp;Alberto Zucchelli,&nbsp;Caterina Trevisan,&nbsp;Gilda Borselli,&nbsp;Raffaele Antonelli Incalzi,&nbsp;Graziano Onder,&nbsp;Antonio Cherubini,&nbsp;Alessandra Marengoni,&nbsp;Alessandro Morandi,&nbsp;Anna Castaldo,&nbsp;Dario Leosco,&nbsp;Giuseppe Dario Testa,&nbsp;Andrea Ungar,&nbsp;Prescription Day LTCFs Workgroup","doi":"10.1007/s40520-025-03183-5","DOIUrl":"10.1007/s40520-025-03183-5","url":null,"abstract":"<div><p>Global population aging is increasing the demand for Long-Term Care Facilities to support older adults with complex health needs. The Prescription Day LTCFs project is a national multicenter point-prevalence study, conducted by the Italian Society of Gerontology and Geriatrics in collaboration with the ANASTE Humanitas Foundation, investigated medication prescription patterns and administration practices in 3,400 residents across 82 facilities in Italy. Participants had a mean age of 84.7 years, with a high prevalence of frailty (49.7%) and polypharmacy (84.8% taking five or more medications). Common chronic conditions included hypertension, dementia, and dysphagia. The study highlighted the complexity of pharmacological regimens, emphasizing risks related to potentially inappropriate medications, drug-drug interactions, and frequent modifications of solid oral dosage forms to facilitate administration in residents with swallowing difficulties or cognitive impairment. These complexities contribute to increased nursing workload. Despite advances in deprescribing research, polypharmacy remains highly prevalent, underlining the need for tailored prescribing guidelines. Variability among Long Term Care Facilities reflects differences in organization and regional healthcare frameworks. The findings provide a valuable foundation for developing strategies to optimize medication management, enhance safety, and improve quality of care in Italian Long Term Care Facilities. This study also offers insights to inform healthcare policies and best practices in pharmacological care for older adults in Long Term Care settings. PRE BIO CE n. 0027032 (20/06/2024), National Ethics Committee, Istituto Superiore di Sanità, Rome, Italy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03183-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynapenic abdominal obesity and the risk of cardiovascular diseases: findings from the China Health and Retirement Longitudinal Study","authors":"Shanghong Zhang,&nbsp;Xiangming Hu,&nbsp;Mingqin Liu,&nbsp;Junguo Jin,&nbsp;Jieliang Liu,&nbsp;Guang Li,&nbsp;Yanqiu Ou,&nbsp;Haojian Dong","doi":"10.1007/s40520-025-03094-5","DOIUrl":"10.1007/s40520-025-03094-5","url":null,"abstract":"<div><h3>Background</h3><p>Dynapenic abdominal obesity (DAO) is a health indicator associating with aging-related disease in older adults. However, no research has clarified the impact of DAO on cardiovascular diseases (CVD). We aim to investigate the distribution of DAO status and its association with subsequent CVD in middle-aged and older adults.</p><h3>Methods</h3><p>Data were derived from 2011 to 2018 in China Health and Retirement Longitudinal Study. The participants were classified as dynapenic abdominal obesity (D/AO), dynapenic non-abdominal obesity (D/NAO), non-dynapenic abdominal obesity (ND/AO) and non-dynapenic non-abdominal obesity (ND/NAO) based on waist circumference (≥ 90 cm for men or ≥ 85 cm for women) and handgrip strength (&lt;28 kg for men or &lt;18 kg for women). CVD was confirmed by medical diagnosis including heart diseases and stroke. Cox proportional hazards regression models were conducted to examine the effect of different DAO status on CVD.</p><h3>Results</h3><p>Among 9150 participants without CVD history, ND/NAO, ND/AO, D/NAO and D/AO accounted for 51.92%, 35.55%, 8.46% and 4.07%, respectively. D/AO (HR 1.63, 95% CI: 1.21–2.20) and ND/AO (HR 1.56, 95% CI: 1.33–1.84) individuals had higher risk of CVD compared to ND/NAO participants. The association between D/AO and ND/AO and risk of CVD were more significant in people less than 65 years old (<i>P</i> = 0.044).</p><h3>Conclusions</h3><p>D/AO and ND/AO were both associated with higher risk of CVD among middle-aged and older adults, which was more pronounced in people younger than 65 years old. The presence of dynapenia further increased the risk of CVD in individuals with AO.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03094-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sarcopenia and its developed status with chronic lung disease in the middle-aged and older Chinese people","authors":"Yi Zhang,&nbsp;Kemeng Zhang,&nbsp;Sui Huang,&nbsp;Mengchen Liu,&nbsp;Wenhan Li,&nbsp;Bijin Luo,&nbsp;Ping He","doi":"10.1007/s40520-025-03192-4","DOIUrl":"10.1007/s40520-025-03192-4","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between sarcopenia and chronic lung disease (CLD) has not been widely studied. We conducted a retrospective cohort study using the China Health and Retirement Longitudinal Study (CHARLS) data to investigate the relationship between sarcopenia status and its developed status and CLD in the middle-aged and older Chinese people.</p><h3>Method</h3><p>We selected 4444 participants over the age of 45 from CHARLS in 2011. Sarcopenia status was defined according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria. CLD was defined as the presence of physician-diagnosed chronic lung disease. We retrospectively assessed their sarcopenia during 2011 and 2013, which were classified into never and newly developed sarcopenia, and these participants were followed from 2013 to 2018.</p><h3>Results</h3><p>During the 2011–2018 follow-up, 554 (12.4%) CLD events were identified. The new incidence rate of CLD in the sarcopenia group, newly developed sarcopenia group, low muscle mass alone group respectively 17.9% (54/302), 17.3% (39/226), and 13.8% (80/576). In the longitudinal analysis, individuals with sarcopenia [HR (95% CI): 1.468(1.068–2.017)] (<i>P</i>&lt;0.01), newly developed sarcopenia [HR (95% CI): 1.486(1.031–2.141)] (<i>P</i>&lt;0.05) and low muscle mass alone [HR (95% CI):1.555(1.174–2.059)] (<i>P</i>&lt;0.01) were more likely to have new onset CLD.</p><h3>Conclusion</h3><p>Sarcopenia, newly developed sarcopenia, and low muscle mass alone were associated with higher CLD risk among middle-aged and older Chinese adults. Therefore, early prevention and treatment of sarcopenia and avoiding its progression may help decrease the incidence of CLD.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03192-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding hand grip measures in geriatric inpatients: associations with frailty, daily functioning and fatigue","authors":"Geeske Peeters,&nbsp;Myrthe M. Swart,&nbsp;Liza De Dobbeleer,&nbsp;Ivan Bautmans,&nbsp;Marcel G.M. Olde Rikkert,&nbsp;René J.F. Melis","doi":"10.1007/s40520-025-03195-1","DOIUrl":"10.1007/s40520-025-03195-1","url":null,"abstract":"<div><h3>Background</h3><p>Hand grip measures are promising candidate markers for recovery in geriatric patients.</p><h3>Aims</h3><p>To advance interpretation of these measures, we examined: (1) the associations between grip measures at admission and measures of frailty, daily functioning and fatigue to understand the constructs they measure; (2) alternate operational definitions of grip measures.</p><h3>Methods</h3><p>181 geriatric inpatients completed twice daily grip measurements using the Eforto^® vigorimeter, including maximum grip strength (GSmax), fatigue resistance (FR), grip work (GW) and capacity to perceived vitality ratio (CPV). Associations with each of these measures and the outcomes frailty index (range 0-100), functional limitations (10–40), and total (4–20) and physical (20–100) fatigue were examined using linear regression. Analyses were repeated for the baseline value, average of first two measurements, within-person standard deviation of all values, and the coefficient of variation of all values for each of the grip measures.</p><h3>Results</h3><p>Associations approached statistical significance for baseline GSmax and the outcomes frailty (B=-0.09, 99%CI=--0.21, 0.02), functional limitations (B=-0.10, 99%CI=-0.20, 0) and physical fatigue (B=-0.07, 99%CI=-0.14, 0). Baseline, average and standard deviation values for FR, GW and CPV showed trends towards associations with functional limitations, but not with frailty or fatigue.</p><h3>Conclusions</h3><p>GSmax and CPV constructs overlapped more strongly with the construct of frailty than FR and GW. FR, GW and CPV overlapped with functional limitations, supporting their potential as early markers of recovery. Average values are more reliable than single values and variance measures may add additional information.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03195-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study","authors":"Elisa Fabbri,&nbsp;Virginia Boccardi,&nbsp;Anna Giulia Guazzarini,&nbsp;Ilenia Murasecco,&nbsp;Francesco Melis,&nbsp;Patrizia Bastiani,&nbsp;Paolo Muratori,&nbsp;Carmelinda Ruggiero,&nbsp;Patrizia Mecocci","doi":"10.1007/s40520-025-03133-1","DOIUrl":"10.1007/s40520-025-03133-1","url":null,"abstract":"<div><h3>Objective</h3><p>To examine the association between burden of multimorbidity and cognitive function in older adults with normal cognition or mild cognitive impairment (MCI).</p><h3>Methods</h3><p>Data from electronic health records of 898 individuals cognitively healthy or with MCI were included. Burden of multimorbidity was assessed using Cumulative Illness Rating Scale-Geriatrics (CIRS-G) total score, while cognitive function was evaluated using a comprehensive battery of neuropsychological tests. Age, sex, education, basic activities of daily living and instrumental activities of daily living scores, and total number of current medications were covariates. Spearmen’s correlations and multivariate regression models investigated the cross-sectional association between burden of multimorbidity and cognitive function.</p><h3>Results</h3><p>At a first exploratory analysis, higher CIRS-G score was significantly and negatively correlated with Addenbrooke’s Cognitive Examination Revised (ACE-R) total score, ACE-R Fluency Score, ACE-R Visual-spatial score, Digit Span Test Forward, Verbal Fluency Test, Visual Search Test and Coloured Progressive Matrices, while it was positively correlated with Trail Making Test A. Fitting fully-adjusted models and independent of all covariates, the inverse association between CIRS-G score and Verbal Fluency Test was confirmed (<i>P</i> &lt;.001), while no significant association was found with other cognitive tests. Noteworthy, we excluded that specific disease categories could have driven the association.</p><h3>Conclusions</h3><p>The burden of multimorbidity is associated with impaired verbal phonemic fluency in individuals with normal cognition or MCI. Although further studies are required to confirm it, impaired verbal phonemic fluency may be an early sign of cognitive decline in older adults with multimorbidity, with potential implications for prevention strategies.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03133-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of unhealthy lifestyle and the risk of type 2 diabetes mellitus with arthritis in middle-aged and elderly Chinese individuals: evidence from the CHARLS","authors":"KaiJian Zhang,&nbsp;Hui Li,&nbsp;JingHan Chu,&nbsp;Nan Chen,&nbsp;HongLi Yan,&nbsp;BuChun Zhang","doi":"10.1007/s40520-025-03196-0","DOIUrl":"10.1007/s40520-025-03196-0","url":null,"abstract":"<div><h3>Background</h3><p>Multimorbidity is an emerging global public health concern. However, the relationship between a healthy lifestyle, type 2 diabetes mellitus (T2DM) and arthritis remains unclear. Our study aimed to evaluate the impact of a healthy lifestyle on the comorbidity of T2DM and arthritis in the Chinese population.</p><h3>Methods</h3><p>The data originated from the China Health and Retirement Longitudinal Study (CHARLS) and comprised 4,706 participants aged 45 years or over. The healthy lifestyle score (0–5) was determined by factors including smoking, drinking, physical activity, sleep and body mass index (BMI). T2DM was assessed using a self-reported physician diagnosis, fasting blood glucose levels ≥ 7.0 mmol/L, or a history of taking hypoglycaemic medication. Arthritis was evaluated using a self-reported physician diagnosis at baseline. Multivariate logistic regression models and stratified analyses were used to estimate the relationship between healthy lifestyles and the risk of T2DM in patients with arthritis. Receiver operating characteristic (ROC) curves were analysed to investigate the association between an unhealthy lifestyle, T2DM and arthritis risk.</p><h3>Results</h3><p>Compared with healthy lifestyle participants, those with unhealthy lifestyles had an increased risk of diabetes (OR = 1.41, 95% CI: 1.01–1.95) and comorbid diabetes‒arthritis (OR = 1.73, 95% CI: 1.01–2.96), but no significant associations with arthritis were detected. In the stratified analysis, stronger associations were found between an unhealthy lifestyle and diabetes-arthritis comorbidity in people aged 45–65 years and in those who were married. ROC analysis revealed high diagnostic accuracy of unhealthy lifestyle for both diabetes (AUC = 0.894) and diabetes-arthritis comorbidity (AUC = 0.894).</p><h3>Conclusion</h3><p>An unhealthy lifestyle was significantly associated with diabetes-arthritis comorbidity among participants ≥ 45 years of age in China, which suggesting that promoting healthy lifestyle may be important for reducing the burden of chronic disease.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03196-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond BMI: central obesity measures and cardiovascular risk in late life","authors":"Onur Erdoğan,&nbsp;Tuğba Erdoğan,&nbsp;Neslihan Hazel Önür,&nbsp;Serdar Özkök,&nbsp;Mehmet Akif Karan,&nbsp;Gülistan Bahat","doi":"10.1007/s40520-025-03197-z","DOIUrl":"10.1007/s40520-025-03197-z","url":null,"abstract":"<div><h3>Background</h3><p>In older adults, age-related changes in body composition may limit the predictive value of traditional obesity measures such as body mass index (BMI). The “obesity paradox,” in which higher BMI appears protective, further complicates cardiovascular risk stratification in this population.</p><h3>Aims</h3><p>To assess the predictive value of various anthropometric indices for ischemic heart disease (IHD) in older adults.</p><h3>Methods</h3><p>This cross-sectional observational study included 1174 community-dwelling adults aged ≥ 65 years evaluated at the university geriatrics outpatient clinic. Anthropometric measures included BMI, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI), relative fat mass (RFM), body fat percentage, and skeletal muscle mass. Multivariate logistic regression analyses were conducted to assess associations with IHD. Receiver operating characteristics (ROC) curve analyses were used to assess discriminatory power.</p><h3>Results</h3><p>The mean age was 75.6 ± 6.9 years; 68.8% were female. IHD was present in 20.3% of participants. WHR(OR = 1.839; 95% CI:1.255–2.695; <i>p</i> = 0.002), WHtR (OR = 1.746; 95% CI:1.250–2.437; <i>p</i> = 0.001), WC (OR = 1.463; 95% CI:1.060–2.020; <i>p</i> = 0.021), and RFM (OR = 1.740; 95% CI:1.257–2.408; <i>p</i> = 0.001), were independently associated with IHD, while BMI, BAI and fat percentage were not. WHR (AUC = 0.611, <i>p</i> &lt; 0.001), WHtR (AUC = 0.561, <i>p</i> = 0.005), and RFM (AUC = 0.555, <i>p</i> = 0.010) demonstrated significant discriminatory performance.</p><h3>Discussion</h3><p>In this geriatric cohort, central obesity measures such as WHR, WHtR and RFM appeared to be more predictive of IHD than BMI. However, the modest discriminatory ability observed suggests these indices may be more valuable when incorporated into multifactorial cardiovascular risk models rather than as standalone screening tools. While BMI’s limitations in older adults are increasingly recognized, our findings provide direct comparative evidence supporting the clinical utility of fat distribution measures in cardiovascular risk assessment.</p><h3>Conclusion</h3><p>These findings support the use of fat distribution indices as part of comprehensive cardiovascular risk assessment in older adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03197-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}