Aging Clinical and Experimental Research最新文献

{"title":"Metabolic dysfunction over a life course key to healthy ageing inequality.","authors":"Katie Littlewood, Jasleen Gegic, Mike Hickman, Richard C J Henson, Jaime R Bishop, Tim Kershaw, Patrick Diamond, Greg Slabaugh, Emmanouil Tranos, Aphrodite Vasilaki, Daniel Tennant, Emilie Courtin, Li F Chan, Sian M Henson","doi":"10.1007/s40520-025-03034-3","DOIUrl":"10.1007/s40520-025-03034-3","url":null,"abstract":"<p><p>The UK is experiencing a decline in healthy life expectancy, now at 62.4 years for men and 60.9 years for women. Socioeconomic deprivation plays a significant role in health disparities, affecting individuals across the life arc. Girls born in the most deprived areas may live 19 fewer years in good health compared to those in wealthier areas. Health inequalities are particularly severe for ethnic minorities, with Black and Asian individuals reporting poorer health at a younger age. Health inequalities correlate with socioeconomic status. In old age, 2.1 million older adults live in poverty, with Black and Asian communities again disproportionately affected. While ageing increases the risk of morbidities, poor health is not inevitable; however, disadvantaged populations face early-life risk factors, such as low birth weight, linked to future conditions like diabetes and cardiovascular disease. CELLO, an interdisciplinary network, focuses on cellular metabolism throughout life in disadvantaged populations, examining how both genetic and environmental factors shape metabolic dysfunction and contribute to social health inequalities. This review stems from discussions within the network, aiming to advance understanding of healthy ageing across the life course.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"191"},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reported prevalence and risk factors of malignant tumors in the elderly population in China: a nationwide cross-sectional study.","authors":"Tianjie Li, Dan Jiang, Meng Fu, Xinye Qian, Zhong Wang, Haifeng Song, Deping Liu, Jianxing Li, Xiaodong Liu","doi":"10.1007/s40520-025-03109-1","DOIUrl":"10.1007/s40520-025-03109-1","url":null,"abstract":"<p><strong>Background: </strong>Malignant tumors are one of the most challenging public health problems facing mankind. It is of great significance to systematically, comprehensively, and fully understand and analyze the prevalence and distribution of malignant tumors in the elderly population.</p><p><strong>Aims: </strong>To evaluate the prevalence and associated factors of malignant tumors in the elderly population in China, and quantify the differences in prevalence and associated factors by urban and rural area, sex, and age.</p><p><strong>Method: </strong>The data is based on Chinese citizens aged 60 and above, using a self-weighted sampling design of stratified, multi-stage, Probability Proportionate to Size Sampling (PPS), and equal-probability sampling at the end of the stage. The analysis included 224,142 valid questionnaires.</p><p><strong>Results: </strong>Among the 215,041 elderly people who participated in the survey, a total of 2,463 participants reported the diagnosis of malignant neoplasms, with a prevalence rate of 1.2%. Urban and rural areas, marital status, living alone, drinking, medical insurance, income, education level and economic status were associated with malignant tumors. Rural household registration, living alone, moderate alcohol consumption, without medical insurance and having income were associated with a lower prevalence of malignant tumors.</p><p><strong>Conclusions: </strong>The prevalence of malignant tumors in urban residents is higher than that in rural residents. There was no significant difference in the overall prevalence of malignancies between sexes. Urban residence, not living alone, higher education level, and poor economic conditions were found to be associated with a higher prevalence of malignant tumors among the elderly, while widowhood and moderate alcohol consumption appeared to be associated with lower prevalence.They could inform future prevention strategies for malignancies and highlight unresolved health disparities.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"194"},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of oral health in older adults aged 65 or over: prevalence, risk factors and prevention.","authors":"Xiao Huang, Lin Kang, Jianghan Bi","doi":"10.1007/s40520-025-03110-8","DOIUrl":"10.1007/s40520-025-03110-8","url":null,"abstract":"<p><p>Oral diseases have emerged as one of the most prevalent non-communicable diseases (NCDs) worldwide, with a high global average prevalence of 45%, affecting an estimated 3.5 billion people globally. With the acceleration of global aging, oral health issues among the older adults have become increasingly prominent. According to the global multi-country epidemiological survey and the WHO report, the prevalence of oral diseases in the elderly aged 65 and above showed a significant increase, and the burden of disease was concentrated on dental caries, periodontal disease and tooth loss. This article synthesizes recent epidemiological data on the rising prevalence of oral health problems in older adults(aged ≥ 65), including inflammatory or non-inflammatory oral diseases, such as dental caries, periodontal disease, tooth loss, oral cancer, dry mouth and dysphagia, illustrates their multidirectional connections with systemic health, their risk factors and prevention, finally advocates for integrating oral health into holistic geriatric care frameworks.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"193"},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of professional environment with loneliness and perceived social isolation among individuals in their second half of life.","authors":"André Hajek, Razak M Gyasi, Dong Keon Yon, Supa Pengpid, Karl Peltzer, Hans-Helmut König","doi":"10.1007/s40520-025-03095-4","DOIUrl":"10.1007/s40520-025-03095-4","url":null,"abstract":"<p><strong>Background: </strong>Little attention has been paid to the association of job-related factors with loneliness and perceived social isolation. More specifically, studies are missing examining how professional environment is associated with loneliness and perceived social isolation.</p><p><strong>Aims: </strong>To examine how the professional environment is associated with loneliness and perceived social isolation (also stratified by sex and age group).</p><p><strong>Methods: </strong>Data were taken from the latest wave of the nationally representative German Ageing Survey (focusing on individuals aged 43 and older living in private households, n = 3,576, mean age: 68.6 years, SD: 11.1 years, with 52.1% being female). Occupations were grouped into six professional environments (realistic, investigative, artistic, social, enterprising, and conventional professions) grounded on Holland's model. More than 550 occupations were classified to one of those six categories based on Stuth's approach. Loneliness and perceived social isolation were quantified using established tools.</p><p><strong>Results: </strong>Our findings revealed that individuals in social (β=-0.08, p < 0.01), enterprising (β=-0.09, p < 0.01), and conventional professions (β=-0.07, p < 0.05) had lower perceived social isolation scores compared to those in realistic professions among the total sample (and particularly among those aged 65 and older); however, no differences in loneliness were observed. Notably, some effects were sex-specific, with men in conventional professions and women in artistic professions experiencing lower perceived social isolation scores. Enterprising professions in particular mainly yielded positive outcomes across groups.</p><p><strong>Discussion: </strong>Our findings underlined the association between professional environment and perceived social isolation, varying by age and sex.</p><p><strong>Conclusions: </strong>Enterprising professions in particular may assist in avoiding perceived social isolation, pending longitudinal evidence. Studies from other countries are recommended.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"195"},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors for falls among nursing home residents in Italy: a retrospective cohort study.","authors":"Pietro Ferrara, Chiara Carla Monti, Davide Rozza, Carla Fornari, Ippazio Cosimo Antonazzo, Maria Cristina Ferrara, Giuseppe Bellelli, Maria Luisa Brandi, Lorenzo G Mantovani, Giampiero Mazzaglia","doi":"10.1007/s40520-025-03111-7","DOIUrl":"10.1007/s40520-025-03111-7","url":null,"abstract":"<p><strong>Background: </strong>Falls are a public health concern among older adults, particularly in nursing home (NH) residents, but in Italy data on fall incidence and risk factors remain limited.</p><p><strong>Aims: </strong>To estimate the incidence of falls, identify associated risk factors, and evaluate the predictive value of the Tinetti Performance-Oriented Mobility Assessment (T-POMA) in a large cohort of NH residents.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using electronic health records from 32 NHs managed by Kos Care company across Italy. Residents aged ≥ 65 years with at least one functional assessment were included. Fall incidence was calculated per 100 person-years. Cox proportional hazards regression models were used to identify predictors of time to first fall.</p><p><strong>Results: </strong>Overall, 754 residents (19.2%) experienced a fall. A T-POMA score ≤ 18 was a strong predictor of falls (HR 2.13; 95% CI: 1.61-2.81), along with age ≥ 85 years (HR 1.39; 1.02-1.90), male sex (HR 1.47; 1.27-1.71), cognitive impairment (HR 1.30; 1.10-1.53), hearing impairment (HR 1.26; 1.01-1.58), mood and behavioural disorders (HR 1.29; 1.09-1.54), and therapies known to increase fall risk (HR 1.29; 1.09-1.52). Poor general health (HR 0.63; 0.52-0.77) and frequent physical restraint (HR 0.70; 0.58-0.86) use were associated with lower fall risk. Severe fall consequences occurred in 15.9% of fallers and were significantly associated with low T-POMA scores and restraint use.</p><p><strong>Discussion and conclusion: </strong>Falls are highly prevalent among Italian NH residents and influenced by multiple clinical and functional factors. These findings support the implementation of multifactorial fall prevention strategies and real-time risk monitoring in NH settings.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"192"},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts.","authors":"Nazario Carrabba, Mattia Alexis Amico, Gherardo Busi, Matteo Vannini, Filippo Bruscoli, Salvatore Fortunato, Luciano Arcari, Emilio Di Lorenzo, Giampaolo Luzi, Francesco Clemenza, Francesco Amico, Giuseppe Pes, Marco Merlo, Gianfranco Sinagra, Giovambattista Desideri, Francesco Vetta, Alessandro Mugelli, Niccolo Marchionni, Alessandro Boccanelli","doi":"10.1007/s40520-025-03085-6","DOIUrl":"10.1007/s40520-025-03085-6","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"190"},"PeriodicalIF":3.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypharmacy and sarcopenia in patients on hemodialysis: results from the SARC-HD study.","authors":"Marvery P Duarte, Nicolle P Marinheiro, Odimar Q Junior, Otávio T Nóbrega, Jéssica G Roure, Fábio A Vieira, Jacqueline F Santana, Maryanne Z C Silva, Dario R Mondini, Henrique S Disessa, Angélica N Adamoli, Daiana C Bündchen, Antonio Vinicius Soares, Rodrigo R Krug, Maristela Bohlke, Antônio J Inda-Filho, Maycon M Reboredo, Moises Wesley, Heitor S Ribeiro","doi":"10.1007/s40520-025-03101-9","DOIUrl":"10.1007/s40520-025-03101-9","url":null,"abstract":"<p><strong>Background: </strong>We investigated the association between polypharmacy and sarcopenia in patients on hemodialysis.</p><p><strong>Methods: </strong>Cross-sectional data from the SARC-HD study were analyzed. Patients were classified according to the number of prescribed medications as no polypharmacy (0-4), polypharmacy (5-9), and hyperpolypharmacy (≥ 10). Sarcopenia was diagnosed and staged according to the adapted EWGSOP2 consensus.</p><p><strong>Results: </strong>955 patients (48% ≥ 60 years, 61% male) were analyzed. Polypharmacy and hyperpolypharmacy were observed in 50% and 26% of patients, respectively. Patients with hyperpolypharmacy had poorer physical function compared to the no polypharmacy group. Low muscle strength was found in 45%, while sarcopenia (confirmed and severe stages) in 21% of the cohort. Patients in the polypharmacy groups had higher prevalence of low muscle strength, but similar sarcopenia rates to those in the no polypharmacy group. Only hyperpolypharmacy was independently associated with low muscle strength (64% higher adjusted odds, 95% CI 1.10-2.46), whereas no significant associations were observed with sarcopenia. Also, each addition of two medications was independently associated with 10% higher adjusted odds (95% CI 1.02-1.20) of low muscle strength.</p><p><strong>Conclusions: </strong>In patients on hemodialysis, the number of medications and hyperpolypharmacy were independently associated with low muscle strength, but not with sarcopenia per se.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"189"},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary live microbes intake and PhenoAge in US non-diabetes adults and the mediating effect of insulin resistance: NHANES 2007-2018.","authors":"Yuhan Yang, Ziyi Sun, Jianguo Lin, Qingqing Wang, Xiaoning Sun, Tong Tong, Xiaoxiao Zhang, Cheng Li, Kuiwu Yao","doi":"10.1007/s40520-025-03104-6","DOIUrl":"10.1007/s40520-025-03104-6","url":null,"abstract":"<p><strong>Background/objectives: </strong>Diets enriched with live microbes offer multiple health benefits. This study aimed to investigate the relationship between dietary intake of live microbes and accelerated biological age, as well as to examine the mediating role of insulin resistance.</p><p><strong>Methods: </strong>The study included 4,909 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. Dietary live microbes intake was assessed using a self-report questionnaire. Insulin resistance was measured using the HOMA-IR and plasma insulin levels. Biological age and accelerated aging were assessed using PhenoAge and PhenoAgeAccel. We performed weighted multiple linear regression, logistic regression, restricted cubic spline (RCS) analysis, mediation analyses, and interaction analyses to explore the relationships between dietary live microbe intake, insulin resistance, and accelerated aging.</p><p><strong>Results: </strong>Higher intake of live dietary microbes, compared to lower intake, was associated with a slower rate of accelerated aging after full adjustment for confounders (β = 0.15; 95% CI: - 0.26 to - 0.04; P = 0.008). RCS curves indicated an L-shaped dose-response relationship (P-nonlinear = 0.0003). Insulin resistance-related metrics (HOMA-IR and insulin) partially mediated these effects, with mediation proportions ranging from 24.65% to 30.03%. Interaction analyses revealed no significant interaction between dietary live microbe intake and other stratification factors regarding phenotypic age.</p><p><strong>Conclusions: </strong>The intake of dietary live microbes is nonlinearly associated with accelerated biological age. IR partially mediated the relationship.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"188"},"PeriodicalIF":3.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between metabolic score for insulin resistance and hypertension in middle-aged and older adults: a nationwide cross-sectional and longitudinal study.","authors":"Weicheng Lai, Lerui Wang, Xiao Chen, Shenshen Du, Yupeng Wu, Liangyan Wu, Huayang Qin, Xin Li, Liangxiu Wu, Boda Zhou","doi":"10.1007/s40520-025-03099-0","DOIUrl":"10.1007/s40520-025-03099-0","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic score for insulin resistance (METS-IR) is a promising and reliable non-insulin-based method for assessing insulin resistance and cardiovascular disease risk. Through cross-sectional and longitudinal analyses, we evaluated the predictive ability of METS-IR for hypertension risk, aiming to provide a basis for early screening and intervention strategies to reduce hypertension-related complications.</p><p><strong>Methods: </strong>Data were utilized from the China Health and Retirement Longitudinal Study (CHARLS), involving participants aged 45 and above with complete METS-IR and self-reported hypertension records. A combination of cross-sectional (waves 1 and 3) and longitudinal designs was used to track hypertension incidence, with 10,738 participants in the cross-sectional analysis and 6,788 participants in the longitudinal analysis. Data collection included health behaviors, physical measurements, and blood tests. METS-IR was calculated using a standardized formula, and hypertension was defined according to established criteria. Statistical analyses assessed associations, with a significance level set at p < 0.05.</p><p><strong>Results: </strong>The cross-sectional analysis, after adjusting for confounders, showed that each unit increase in METS-IR was associated with a threefold increase in the risk of hypertension (adjusted OR = 3.48, 95% CI: 2.87, 4.21, P < 0.0001). A significant nonlinear relationship between METS-IR and hypertension risk was observed, particularly beyond a value of 2.0, where the risk significantly increased. Subgroup analysis revealed that smoking and sex significantly affected this association. Longitudinal analysis demonstrated that each unit increase in METS-IR was significantly associated with increased hypertension incidence at 2 years (OR = 1.54, 95% CI: 1.09, 2.18, P < 0.05), 5 years (OR = 1.52, 95% CI: 1.17, 1.97, P < 0.05), and 7 years (OR = 1.71, 95% CI: 1.38, 2.12,, P < 0.0001), respectively.</p><p><strong>Conclusion: </strong>Using CHARLS data, we found that higher METS-IR independently predicts hypertension incidence and prevalence in Chinese older adults.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"187"},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the quality of life and resilience of family caregivers of stroke survivors through education based on the Roy's adaptation model: a randomized controlled trial.","authors":"Amin Monjezi, Arezou Karampourian, Salman Khazaei, Mojtaba Khazaei","doi":"10.1007/s40520-025-03096-3","DOIUrl":"10.1007/s40520-025-03096-3","url":null,"abstract":"<p><strong>Objective: </strong>The dependence of stroke survivors on family caregivers negatively affects the quality of life, resilience, and adaptation of these caregivers. This study was conducted to identify the effect of education on the quality of life, resilience, and adaptation of family caregivers of stroke survivors based on Roy's adaptation model (RAM).</p><p><strong>Study design and methodology: </strong>This randomized clinical trial, conducted in 2023, enrolled 104 family caregivers of stroke survivors. Participants were chosen using the available method and then assigned to either the intervention or control groups through the random block method. In the intervention group, participants received four education sessions and telephone follow-ups. Tools, including a demographic information form, the Roy's Adaptation Model Assessment Form (RAM-AF), the Adult Carers Quality of Life Questionnaire (AC-QOL), and the Connor and Davidson Resilience Questionnaire (CD-RISC), were used. The final evaluation was performed two months after the intervention.</p><p><strong>Findings: </strong>Most participants in both groups were female (56.1%), married (59.2%), and had a son or daughter relationship with the patient (73.5%). The average age of the participants was 40.61 ± 10.77 years. The scores for quality of life, resilience, and adaptation did not exhibit significant differences between the intervention and control groups before the intervention (P > 0.05). However, a significant difference emerged after the intervention (P < 0.001).</p><p><strong>Conclusion: </strong>The results indicate that education based on RAM can enhance the adaptive response of family caregivers of stroke survivors and improve their physical, mental, and social health. (IRCT20230208057360N2 and date: 2023-06-21).</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"185"},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}