Aging Clinical and Experimental Research最新文献

Correspondence for the article: “Association between gut microbiota and sarcopenia in older adults: a cross-sectional analysis from the second wave of the Birjand Longitudinal Aging Study (BLAS)” 文章对应：“老年人肠道微生物群与肌肉减少症之间的关系：来自Birjand纵向衰老研究（BLAS）第二波的横断面分析”。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-10-15 DOI: 10.1007/s40520-026-03430-3

Maajid Mohi Ud. Din Malik, Supriya S. Desai

引用次数: 0

Stroke burden and associated predictors: A methodological reflection 脑卒中负担及相关预测因素：方法学反思。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-10-15 DOI: 10.1007/s40520-026-03497-y

Aria Hosseini, Rayeheh Bozorgi, Amir Molavi zad, Kosim Rakhmanov, Guloyim Avezova, Shukhrat Teshayev

引用次数: 0

Refining risk prediction in geriatric heart failure: the emergency heart failure mortality risk grade‑BI model under scrutiny 改进老年心力衰竭的风险预测：紧急心力衰竭死亡率风险等级- BI模型正在审查中。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-10-15 DOI: 10.1007/s40520-026-03537-7

Kianoush A. h. Saberi L., Durdona Alimova, Sherzod Niyazov, Kholmurod Qayumov, Parvina Gaffarova, Xamida Juraqobilova, Zaynura Kadirova

{"title":"Refining risk prediction in geriatric heart failure: the emergency heart failure mortality risk grade‑BI model under scrutiny","authors":"Kianoush A. h. Saberi L., Durdona Alimova, Sherzod Niyazov, Kholmurod Qayumov, Parvina Gaffarova, Xamida Juraqobilova, Zaynura Kadirova","doi":"10.1007/s40520-026-03537-7","DOIUrl":"10.1007/s40520-026-03537-7","url":null,"abstract":"<div><p>Risk stratification is critical for managing acute heart failure in older adults, yet existing tools often underperform in geriatric populations. Özdemir recently introduced the EHMRG‑BI model, integrating brain natriuretic peptide and endotracheal intubation with the Emergency Heart Failure Mortality Risk Grade score to improve 30‑day mortality prediction. While the model demonstrates improved discrimination in a single‑center derivation cohort, several methodological considerations warrant attention. The inclusion of intubation, a treatment decision rather than a baseline characteristic, may introduce bias and limit its utility as an arrival‑time tool. The absence of key geriatric domains such as frailty, functional status, and cognitive impairment may result in residual confounding. Additionally, modelling BNP as a linear predictor disregards its well‑documented non‑linear association with mortality. This Matters Arising offers a perspective on these challenges and proposes refinements, including external validation, integration of geriatric assessments, and flexible BNP modelling, to strengthen the model’s clinical applicability.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03537-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OsteoStrong and dynamic exercise in older women: rethinking comparative effectiveness 老年妇女的强健骨和动态运动：重新思考比较效果。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-10-15 DOI: 10.1007/s40520-026-03536-8

Furkat Ruzmetov, Rizaev Jasur, Laziz Jumayev, Aminjon Amonov, Xondamir Ahmadov, Baxodir Usmanov, Farrukh Narzullayev, Tarazi Naghashidi

{"title":"OsteoStrong and dynamic exercise in older women: rethinking comparative effectiveness","authors":"Furkat Ruzmetov, Rizaev Jasur, Laziz Jumayev, Aminjon Amonov, Xondamir Ahmadov, Baxodir Usmanov, Farrukh Narzullayev, Tarazi Naghashidi","doi":"10.1007/s40520-026-03536-8","DOIUrl":"10.1007/s40520-026-03536-8","url":null,"abstract":"<div><p>Exercise is a cornerstone of osteoporosis management, yet the comparative effectiveness of isometric machine‑based training versus dynamic multicomponent exercise remains unclear. Lindberg and colleagues conducted a randomized trial comparing OsteoStrong (OS) to dynamic multicomponent exercise (DME) in 194 older women with osteopenia or osteoporosis, finding superior improvements in gait speed, back endurance, and balance with DME. While these findings are clinically relevant, several methodological considerations warrant attention: the six‑fold difference in training volume (20 vs. 120 min/week) confounds modality comparisons; functional outcomes were interpreted as superiority evidence despite the trial’s non‑inferiority design; participants’ high baseline activity may limit generalizability; and unblinded follow‑up assessments risk detection bias. We offer a perspective on these methodological challenges and proposes directions for future research to refine exercise recommendations for this population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03536-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Hospital-associated complications in older adults: methodological considerations 预测老年人医院相关并发症：方法学考虑

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-10-15 DOI: 10.1007/s40520-026-03507-z

Shukhrat Valiev, Dilnavoz Yuldasheva, Malika Khojimatova, Dilorom Saidova, Shaxlo R. Sodiqova, Nizom Ermatov, Zeynab Afzali

{"title":"Predicting Hospital-associated complications in older adults: methodological considerations","authors":"Shukhrat Valiev, Dilnavoz Yuldasheva, Malika Khojimatova, Dilorom Saidova, Shaxlo R. Sodiqova, Nizom Ermatov, Zeynab Afzali","doi":"10.1007/s40520-026-03507-z","DOIUrl":"10.1007/s40520-026-03507-z","url":null,"abstract":"<div><p>Machine learning is increasingly used to predict post-surgical complications, but predictive performance does not guarantee clinical readiness. Shimizu and colleagues developed a promising model for older adults undergoing tibial fracture surgery using a large Japanese database. However, four methodological pitfalls warrant attention. First, the composite outcome was not validated in this population, and excluding in-hospital deaths introduced survivorship bias, underestimating the true burden of severe complications. Second, days to surgery, a variable not known at admission, created target leakage that inflates performance and undermines the admission-time claim. Third, using the test set for feature selection violated TRIPOD guidelines and likely overstated the scorecard’s utility. Fourth, the Super Learner exhibited substantial overfitting, with a 0.110 drop between training (AUC = 0.850) and test (AUC = 0.740) performance, while offering only marginal improvement over simpler models. We suggest redeveloping the model with proper internal validation, excluding leakage-prone predictors, treating death as a competing risk, and prioritizing interpretability when complex ensembles offer limited added value. External validation remains essential before clinical implementation.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03507-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can grip strength capture what chair standing does? methodological considerations on functional measures and successful aging in three international cohorts 握力能抓住椅子站立做什么？三个国际队列的功能测量和成功老龄化的方法学考虑。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-10-15 DOI: 10.1007/s40520-026-03523-z

Zebo Kudratova, Azamat Karabaev, Vazira Raxmanova, Arofat Sadikova, Shahlo Axmadjonova, Farzan Vira Bagheri

{"title":"Can grip strength capture what chair standing does? methodological considerations on functional measures and successful aging in three international cohorts","authors":"Zebo Kudratova, Azamat Karabaev, Vazira Raxmanova, Arofat Sadikova, Shahlo Axmadjonova, Farzan Vira Bagheri","doi":"10.1007/s40520-026-03523-z","DOIUrl":"10.1007/s40520-026-03523-z","url":null,"abstract":"<div><p>Population aging has accelerated globally, making successful aging a key public health priority. Zhuang and Gao address the prospective association between cumulative average grip strength and successful aging using three international cohorts. While their multi-cohort design offers valuable cross-population insights, several methodological choices warrant consideration. Grip strength may not fully capture functional determinants of successful aging. Self-reported chronic disease introduces misclassification bias varying across socioeconomic groups. The two-stage temporal design does not fully address selection bias and cross-cohort comparability from heterogeneous exposure windows. Additionally, the cohort-relative cognitive threshold undermines cross-population comparability. These considerations highlight the need for methodological reflection and suggest directions for strengthening future multi-cohort studies.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03523-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to pacemaker insertion in older adults: A perspective on mortality and functional outcomes 老年人心脏起搏器植入时间：死亡率和功能结局的观点。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-09-23 DOI: 10.1007/s40520-026-03514-0

Rezam Kazemerof, Maria Mikhailova, Sarboz Nurov, Adham Akhmedov, Farhad Akilov, Oybek Ismailov

引用次数: 0

Reducing concerns about falling in older adults: evaluation of a multi-component intervention and the role of stress and inflammation markers - long-term effects of the FEARFALL randomized controlled trial 减少老年人对跌倒的担忧：多组分干预的评估以及应激和炎症标志物的作用——FEARFALL随机对照试验的长期影响

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-09-19 Epub Date: 2026-09-23 DOI: 10.1007/s40520-026-03515-z

Sabine Britting, Anja Müller, Robert Kob, Ellen Freiberger, Nicolas Rohleder

{"title":"Reducing concerns about falling in older adults: evaluation of a multi-component intervention and the role of stress and inflammation markers - long-term effects of the FEARFALL randomized controlled trial","authors":"Sabine Britting, Anja Müller, Robert Kob, Ellen Freiberger, Nicolas Rohleder","doi":"10.1007/s40520-026-03515-z","DOIUrl":"10.1007/s40520-026-03515-z","url":null,"abstract":"<div><h3>Background</h3><p>Concerns about falling (CaF) are common in older adults and associated with reduced activity and poorer health. This study investigated, for the first time, the long-term effects of a multi-component intervention targeting CaF on psychological, functional, biophysiological, and anthropometric outcomes.</p><h3>Methods</h3><p>160 community-dwelling older adults (≥ 70 years) were randomly assigned to a 4-month intervention featuring exercise and cognitive-behavioral training or to a sham control group. CaF and related psychological outcomes were assessed using validated questionnaires. Salivary cortisol and α-amylase, physical function, activity, body composition and inflammatory markers (C-reactive protein [CRP]-, interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-1β [IL-1β] and tumor necrosis factor-alpha [TNF-α]) were analyzed at baseline, post-intervention, and 8-month follow-up.</p><h3>Results</h3><p>All estimates represent T0–T2 estimated marginal mean differences. There was no intervention effect or long-term superiority between the groups. Significant time effects were observed for CaF and physiological biomarkers for stress axis activity and inflammatory markers. Functional outcomes changed only marginally.</p><h3>Conclusion</h3><p>CaF improved similarly in both groups. Changes in basal stress system activity and inflammatory cytokines were highly comparable between groups. Contrary to our hypothesis, the intervention did not confer additional benefits over the sham control intervention in reducing CaF.</p><h3>Trial registration</h3><p>German Clinical Trials Register (DRKS): DRKS00029171. Registered 22 July 2022, https://drks.de/search/de/trial/DRKS00029171.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03515-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: Food insecurity and mortality in older adults: a prospective reconstruction 老年人的粮食不安全和死亡率：一个前瞻性的重建。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-09-08 DOI: 10.1007/s40520-026-03506-0

Vincenza Gianfredi, Daniele Nucci, Pinar Soysal, Stefania Maggi, Alberto Castagna, Andrea Cozza, Vincenzo Baldo, Nicola Veronese

引用次数: 0

Social vulnerability and psychological resources in aging: the role of index weighting and attrition bias 老龄化中的社会脆弱性与心理资源：指标加权和损耗偏差的作用。

IF 4.7 3区医学

Aging Clinical and Experimental Research Pub Date : 2026-09-08 DOI: 10.1007/s40520-026-03491-4

Kianoush Saberi, Mahgol Jahanfar, Nikki Ghadiminia, Sepideh Amin Afshari, Hosein Haghirinezhad

引用次数: 0