Aging Clinical and Experimental Research最新文献

{"title":"Slow gait speed is associated with frailty, activities of daily living and nutritional status in in-patient pulmonology patients","authors":"Asli Gorek Dilektasli,&nbsp;Nilüfer Aylin Acet Öztürk,&nbsp;Demet Kerimoğlu,&nbsp;Ayten Odabaş,&nbsp;Mine Tül Yaman,&nbsp;Abdurrahman Dogan,&nbsp;Ezgi Demirdogen,&nbsp;Ozge Aydın Guclu,&nbsp;Funda Coşkun,&nbsp;Ahmet Ursavas,&nbsp;Mehmet Karadağ","doi":"10.1007/s40520-025-03040-5","DOIUrl":"10.1007/s40520-025-03040-5","url":null,"abstract":"<div><h3>Background and aim</h3><p>The 4-meter gait speed (4MGS), a functional performance test, is increasingly used to predict health outcomes. This study investigated 4MGS, nutritional status, frailty, and daily living activities in tertiary care pulmonary diseases ward patients.</p><h3>Methods</h3><p>Patients were assessed for nutritional status, activities of daily living, and frailty using the Mini Nutritional Assessment (MNA) Test, Barthel Questionnaire, and FRAIL scale. Those with 4MGS &lt; 1 m/sec were classified as having slow gait speed.</p><h3>Results</h3><p>80 patients (F/M: 21/59, mean age 58 ± 19) were included. Diagnoses included pneumonia, chronic obstructive pulmonary disease, pleural effusion, and interstitial lung disease. Patients had a 4MGS of 0,74 ± 0,24 m/sn, MNA score of 14.0 [IQR 25–75:11.0–19.8] points, Barthel index of 95 [IQR 25–75:70–100] points, FRAIL scale of 3 [IQR 25–75:1.0–4.0], and a hand-grip strength of 18.8 [IQR 25–75:15.7–25.9] kg. Slow gait speed patients had lower MNA, FRAIL scores, and handgrip strength. Multivariable regression analysis showed that slower gait speed was associated with lower serum protein level (B = 0.013, SE = 0.005, 95% CI: 0.004 to 0.022, <i>p</i> = 0.004), lower hand grip strength (B = -0.002, SE = 0.001, 95% CI: -0.003 to -0.00006, <i>p</i> = 0.041) and malnutrition risk (B = 0.024, SE = 0.007, 95% CI: 0.011 to 0.038, <i>p</i> &lt; 0.001).</p><h3>Discussion and conclusion</h3><p>4MGS correlates with comorbidities, frailty, grip strength, and nutritional status in hospitalized pulmonary patients. Slow gait patients are more malnourished despite similar age, sex, BMI, and comorbidities.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03040-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary quality and biological aging: two-mediation analysis","authors":"Li-Sha Zeng,&nbsp;Yi-Ting Wu,&nbsp;Feng-Ping Zhang","doi":"10.1007/s40520-025-03038-z","DOIUrl":"10.1007/s40520-025-03038-z","url":null,"abstract":"<div><h3>Aims</h3><p>Previous research has emphasized the firm link between diet and human health. However, the connection between comprehensive dietary patterns and biological aging has not been fully investigated. Our aim was to explore the potential association between dietary quality and delaying aging.</p><h3>Methods</h3><p>A total of 20,763 participants from the National Health and Nutrition Examination Survey were included in this cross-sectional study. The Mediterranean diet score (MDS), dietary approaches to stop hypertension index (DASHI), and healthy eating index 2020 (HEI2020) were utilized to assess dietary quality. Biological age was determined using the Klemera-Doubal method (KDM) biological age and phenotypic age (Levine’s), with the difference between biological age and chronological age representing aging acceleration. Independent relationships between dietary quality and biological aging were analyzed using weighted adjusted linear and logistic regression. Nonlinear trends and robustness of conclusions were examined. A secondary objective was to examine the role of Klotho and γ-glutamyltransferase (GGT) in mediation analyses.</p><h3>Results</h3><p>Dietary quality exhibited a negative association with biological aging, as evidenced by the interplay between three dietary patterns and two aging measures (The β of the linear regressions were all &lt; 0). Restricted cubic splines confirmed the linear relationship, while subgroup interactions bolstered the stability of the results. Mediation analysis indicated that klotho and GGT partially mediated the association between dietary quality and biological aging (combined proportion mediation: 4.1-8.0%).</p><h3>Conclusion</h3><p>Dietary quality is closely associated with biological aging, with anti-aging proteins and oxidative stress potentially serving as underlying mediation mechanisms.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03038-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a text message + pedometer intervention to increase steps after emergency department discharge: a pilot study","authors":"Brian Suffoletto,&nbsp;Waverly Mayer,&nbsp;Caitlin Toth,&nbsp;Nick Ashenburg,&nbsp;Michelle Lin,&nbsp;Michael Losak,&nbsp;David Kim","doi":"10.1007/s40520-025-03030-7","DOIUrl":"10.1007/s40520-025-03030-7","url":null,"abstract":"<div><h3>Background</h3><p>Older adults face increased risk of functional impairments after Emergency Department (ED) discharge, yet no evidence-based interventions exist for this population.</p><h3>Objective</h3><p>To evaluate the feasibility, safety, and effectiveness of Safe Steps, a text message + pedometer intervention designed to motivate individuals to meet step count goals.</p><h3>Methods</h3><p>We recruited ED patients aged ≥ 60 with low physical activity. Participants received a pedometer in the ED, daily text messages to report steps, and weekly prompts to set step goals over 4 weeks. We assessed step count reporting rates, falls, and change in steps over time.</p><h3>Results</h3><p>Among analyzed participants (<i>n</i> = 40), daily step reporting was high (95% of weeks with 2 + readings). No participants had falls due to the intervention. Step count increased by a mean of 359 steps per week (95% confidence interval 182–536).</p><h3>Conclusion</h3><p>Safe Steps appears feasible, safe, and may be effective for promoting activity after ED discharge.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03030-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study","authors":"Jili Liu,&nbsp;Xin Xia,&nbsp;Zhaolin Wang,&nbsp;Yanqin Wang,&nbsp;Gang Qin","doi":"10.1007/s40520-025-03012-9","DOIUrl":"10.1007/s40520-025-03012-9","url":null,"abstract":"<div><h3>Background</h3><p>Musculoskeletal disease, which has a complicated relationship with frailty, is a common clinical problem among elderly individuals.</p><h3>Aims</h3><p>This study evaluated the potential causal relationships between osteosarcopenia, osteoarthritis and frailty by Mendelian Randomization (MR) analysis.</p><h3>Methods</h3><p>This study employed a two-sample MR approach to investigate the causal relationships among osteosarcopenia, osteoarthritis and frailty. Published summary statistics were used to obtain instrumental variables at the genome-wide significance level.</p><h3>Results</h3><p>Among the age groups with osteoporosis, high total bone mineral density (TBMD) (45—60, OR = 0.966, 95% CI 0.940–0.993, <i>P</i> = 0.013) and TBMD (over 60, OR = 0.974, 95% CI 0.954–0.994, <i>P</i> = 0.011) reduced the risk of frailty. Similarly, high forearm BMD (FA-BMD), high ultradistal forearm BMD (UFA-BMD), and high Heel-BMD at different sites also reduced the risk of frailty (OR = 0.966, 95% CI 0.936–0.996, <i>P</i> = 0.028; OR = 0.975, 95% CI 0.953–0.997, <i>P</i> = 0.029; OR = 0.981, 95% CI 0.967–0.995, <i>P</i> = 0.008). Among the characteristics related to sarcopenia, grip strength in the left hand, grip strength in the right hand, appendicular lean mass, and walking pace were all protective factors for frailty (OR = 0.788, 95% CI 0.721–0.862, <i>P</i> &lt; 0.001; OR = 0.800, 95% CI 0.737–0.869, <i>P</i> &lt; 0.001; OR = 0.955, 95% CI 0.937–0.974, <i>P</i> = 0.000; OR = 0.480, 95% CI 0.388–0.593, <i>P</i> &lt; 0.001), with low grip strength in those over 60 years of age significantly positively correlated with frailty (OR = 1.168, 95% CI 1.059–1.289, <i>P</i> = 0.002). The MR results of osteoarthritis and frailty revealed a causal relationship between specific joint sites and frailty, including KOA (OR = 1.086, 95% CI 1.017–1.160, <i>P</i> = 0.014), HOA (OR = 1.028, 95% CI 1.007–1.049, <i>P</i> = 0.009), and KOA/HOA (OR = 1.082, 95% CI 1.053–1.113, <i>P</i> = 0.000), increasing the risk of frailty.</p><h3>Conclusion</h3><p>Osteosarcopenia, osteoarthritis and frailty exhibit significant causal effects, rendering them risk factors for frailty. Therefore, in clinical practice, patients with osteosarcopenia and osteoarthritis should be required to undergo relevant interventions to reduce the risk of frailty.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03012-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China","authors":"Caihong He,&nbsp;Yihan Wang,&nbsp;Chengfan Qin,&nbsp;Nan Hua,&nbsp;Yichen Yang,&nbsp;Jing Chen,&nbsp;Qin Zhang","doi":"10.1007/s40520-025-03032-5","DOIUrl":"10.1007/s40520-025-03032-5","url":null,"abstract":"<div><h3>Background</h3><p>Tooth loss was linked to health status, with substantial implications for malnutrition and chronic inflammation risks in older adults, especially among vulnerable groups. This study aimed to explore the associations between tooth loss severity, denture status, and geriatric syndromes.</p><h3>Methods</h3><p>In 2019, 1094 participants were recruited and subjected to face-to-face interview to assess tooth loss severity, along with grip strength and body composition. In 2023, a follow-up was conducted with a subsample of the participants. Logistic regression analysis was utilized to explore the association between tooth loss severity at baseline and geriatric syndromes (sarcopenia, malnutrition risk, frailty, fall) at fourth year follow-up, as well as association between denture status and geriatric syndromes.</p><h3>Results</h3><p>The multivariate analyses showed that having tooth loss affecting daily life at baseline was associated with a 1.80-fold higher prevalence of sarcopenia and 2.31-fold higher prevalence of malnutrition risk after four years. Participants with fewer than 10 teeth had significantly higher odds of geriatric syndromes compared to those with 21 or more teeth: 1.87-fold for sarcopenia (95% CI: 1.07 to 3.26), 2.99-fold for malnutrition risk (95% CI: 1.93 to 4.62), and 1.68-fold for frailty (95% CI: 1.10 to 2.56). Older adults with tooth loss who did not have dentures exhibited a significantly higher odds of sarcopenia, malnutrition risk, frailty, and falls, more number of geriatric syndromes.</p><h3>Conclusion</h3><p>Higher severity level of tooth loss at baseline were associated with higher odds of geriatric syndromes at fourth year in older adults. Dentures partially mitigate the association between tooth loss and the higher odds of geriatric syndromes. Screening and intervening oral health is important for the prevention of geriatric syndromes in older adults.</p><h3>Clinical trial number</h3><p>Not applicable.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03032-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visuospatial impairment in dementia: a new index to improve the clinical diagnosis of Alzheimer’s disease","authors":"Francesca Santagata,&nbsp;Stefano F. Cappa,&nbsp;Roberto Presta,&nbsp;Caterina Burgio,&nbsp;Chiara Luppi,&nbsp;Massimiliano Massaia,&nbsp;Elisa Calvi,&nbsp;Patrizia D’Amelio","doi":"10.1007/s40520-025-03028-1","DOIUrl":"10.1007/s40520-025-03028-1","url":null,"abstract":"<div><h3>Background</h3><p>The differential diagnosis between Alzheimer’s disease (AD) and other causes of dementia is essential but challenging. Therefore, there is an increasing need for early, reliable, and non-invasive tests to distinguish between different forms of dementia.</p><h3>Aims</h3><p>To determine whether neuropsychological tests assessing visuospatial function can improve confidence in the clinical diagnosis of AD.</p><h3>Methods</h3><p>Retrospective observational single-center cohort study involving all patients consecutively referred to our outpatient clinic for cognitive disorders who underwent neuropsychological assessment between 2013 and 2018. In addition to demographic and functional variables, each patient underwent neuropsychological tests to assess cognitive performance, memory, and executive, language, and visuospatial ability, according to clinical protocols. The clinical diagnosis of cognitive disorders, based on standard diagnostic criteria, served as the gold standard. Accuracy measures of visuospatial tests to diagnose AD were calculated. Additionally, a new index derived from the sum of four items (Rey-Osterrieth figure copying, Copy of Drawings, Clock Drawing Test, and years of schooling) was tested (ReDCOOL).</p><h3>Results</h3><p>Of the 342 patients analyzed, 308 were diagnosed with dementia or mild cognitive impairment, including 60 with AD. AD patients exhibited the worst performance in visuospatial tests, and the utilization of the ReDCOOL index proved to be more dependable in identifying AD compared to other tests (AUROC 0.729, 95%CI 0.659–0.799; <i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>The ReDCOOL index appears to increase confidence in the clinical diagnosis of AD compared to each of the visuospatial tests considered. Furthermore, this index is easily calculated and does not prolong the time needed for clinical evaluation, as it does not require a customized patient assessment.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03028-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sarcopenic obesity and depression in middle-aged and elderly U.S. adults: insights from the NHANES study","authors":"Xiaoming Zhang,&nbsp;Rui Zeng,&nbsp;Wenwu Zhang,&nbsp;Fayi Xie,&nbsp;Aizhang Zhu,&nbsp;Lihuan Chen,&nbsp;Ke Zhu,&nbsp;Tenghui Fan,&nbsp;Yishan Wu,&nbsp;Xu Luo,&nbsp;Yuxu Huang,&nbsp;Dongmei Ye,&nbsp;Jiahui Bian,&nbsp;Wan Zhu,&nbsp;Jiang Wang,&nbsp;Qingli Dou,&nbsp;Conghua Wang","doi":"10.1007/s40520-025-02947-3","DOIUrl":"10.1007/s40520-025-02947-3","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to explore the association between sarcopenia, obesity, and sarcopenic obesity with depression in a middle-aged and elderly population in the United States.</p><h3>Methods</h3><p>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2006 and from 2011 to 2018, including 5155 participants aged 45 years and older. Obesity was defined by a body mass index (BMI) ≥ 30 or waist circumference (WC) ≥ 102 cm in men or ≥ 88 cm in women. Sarcopenia was assessed using dual-energy X-ray absorptiometry (DXA) to calculate appendicular skeletal muscle mass index (ASMI), with gender-specific cut-offs. Multivariate logistic regression models adjusted for various covariates were used to assess the associations.</p><h3>Results</h3><p>Participants classified into the sarcopenia-only, obesity-only, and sarcopenic obesity groups exhibited multivariable-adjusted odds ratios (ORs) for depression of 1.35 (95% CI 0.60–2.18; P = 0.371), 1.37 (95% CI 1.03–1.82; P = 0.031), and 2.07 (95% CI 1.36–3.16; P &lt; 0.001), respectively, compared to the robust group. Sensitivity analyses using alternative definitions of obesity and multiple imputation for missing data confirmed these findings. Subgroup analyses revealed that the association between sarcopenic obesity and depression was more pronounced in middle-aged women (aged ≤ 52 years).</p><h3>Conclusion</h3><p>This study underscores the significant relationship between sarcopenic obesity and depression in a large U.S. middle-aged and elderly population. Interventions focusing on weight control and muscle mass enhancement through proper nutrition and physical activity may reduce depression incidence, thereby promoting healthy aging.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02947-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia","authors":"Huixian Lu,&nbsp;Caixia Xu,&nbsp;Jiaquan Liang","doi":"10.1007/s40520-025-03023-6","DOIUrl":"10.1007/s40520-025-03023-6","url":null,"abstract":"<div><h3>Aim</h3><p>Alzheimer’s disease (AD) is a major cause of dementia, marked by cognitive decline and behavioral and psychological symptoms of dementia (BPSD). Early differentiation between AD, mild cognitive impairment (MCI), and healthy controls (HC) is essential for improving diagnostic accuracy and guiding effective treatment strategies.</p><h3>Methods</h3><p>This retrospective study included 120 participants divided into AD (<i>n</i> = 40), MCI (<i>n</i> = 40), and HC (<i>n</i> = 40) groups. Brain MRI data were analyzed using the AccuBrain system to quantify AD Resemblance Atrophy Index (AD-RAI), Quantitative Medial Temporal Atrophy (QMTA), hippocampal volume, and white matter hyperintensities. Correlation analyses were conducted between imaging biomarkers and cognitive function scores (Mini-Mental State Examination, MMSE; Neuropsychiatric Inventory, NPI). Receiver operating characteristic (ROC) curve analysis was used to evaluated the diagnostic performance of the biomarkers.</p><h3>Results</h3><p>AD patients had significantly higher AD-RAI (0.91 ± 0.25) and more pronounced hippocampal atrophy (0.36 ± 0.09) compared to MCI and HC (<i>P</i> &lt; 0.001). Correlation analyses showed that AD-RAI and QMTA were negatively correlated with MMSE scores (<i>r</i> = -0.718, <i>P</i> &lt; 0.001; <i>r</i> = -0.463, <i>P</i> &lt; 0.001), while hippocampal volume was positively correlated with MMSE (<i>r</i> = 0.408, <i>P</i> &lt; 0.001). ROC analysis revealed that AD-RAI had an AUC of 0.777 for distinguishing AD from MCI, while QMTA had an AUC of 0.938 for distinguishing AD from HC. BPSD patients exhibited higher AD-RAI (1.09 ± 0.18) and greater hippocampal atrophy, with ROC AUC &gt; 0.9 for distinguishing BPSD from non-BPSD patients.</p><h3>Conclusion</h3><p>The AccuBrain MRI system demonstrated high sensitivity and diagnostic value in distinguishing AD from MCI and HC, as well as in identifying patients with BPSD. Correlation and ROC analyses support the use of these imaging biomarkers for early diagnosis and personalized treatment strategies in AD.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03023-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging, longevity, and healthy aging: the public health approach","authors":"Vincenza Gianfredi,&nbsp;Daniele Nucci,&nbsp;Flavia Pennisi,&nbsp;Stefania Maggi,&nbsp;Nicola Veronese,&nbsp;Pinar Soysal","doi":"10.1007/s40520-025-03021-8","DOIUrl":"10.1007/s40520-025-03021-8","url":null,"abstract":"<div><h3>Background</h3><p>Population aging is one of the most significant global demographic changes of the 21st century, driven by increased life expectancy and declining fertility rates. This phenomenon presents both achievements and challenges for public health systems worldwide.</p><h3>Aims</h3><p>On the one hand, advances in healthcare and socio-economic conditions have contributed to longer lives and improved quality of life for older adults. On the other hand, aging populations are increasingly affected by chronic diseases, greriatric syndromes, and multimorbidity, leading to greater healthcare demands and higher associated costs.</p><h3>Methods</h3><p>This manuscript explores evidence on regards of the impact of aging on healthcare and economic systems, emphasizing the need for a paradigm shift toward healthy aging.</p><h3>Results</h3><p>Healthy aging, as defined by the World Health Organization, focuses on the maintenance of intrinsic capacity, physical, mental, and social well-being throughout life. It highlights the importance of preventive healthcare, proper nutrition, and regular physical activity in delaying the onset of chronic conditions and maintaining functional independence. Furthermore, the manuscript addresses the challenges faced by healthcare infrastructures and pension systems as they adapt to aging populations, with particular attention to the strain caused by workforce shortages and the rising need for long-term care.</p><h3>Discussion</h3><p>A coordinated public health approach is essential to promote healthy aging and mitigate the economic and societal impacts of population aging.</p><h3>Conclusions</h3><p>This paper underscores the need for integrated health policies and multidisciplinary care models to ensure that longer life expectancy is accompanied by better quality of life for older individuals.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03021-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of corticosteroid withdrawal on bone mineral density after kidney transplantation","authors":"Antoine Bouquegneau,&nbsp;Marie Ernst,&nbsp;Olivier Malaise,&nbsp;Laurence Seidel,&nbsp;Jean-François Kaux,&nbsp;Jean-Yves Reginster,&nbsp;Etienne Cavalier,&nbsp;Clio Ribbens,&nbsp;François Jouret,&nbsp;Laurent Weekers,&nbsp;Pierre Delanaye","doi":"10.1007/s40520-025-03018-3","DOIUrl":"10.1007/s40520-025-03018-3","url":null,"abstract":"<div><h3>Background</h3><p>Bone abnormalities are common after kidney transplantation (KTx) and are associated with an increased risk of fractures. The pathophysiology of post-KTx bone disorders is multifactorial, with corticosteroid (CS) therapy being a contributor to the loss of bone mineral density (BMD). This study aimed to evaluate the impact of CS withdrawal versus continued CS therapy on BMD evolution in a kidney transplant recipients (KTRs) cohort.</p><h3>Methods</h3><p>We retrospectively analyzed BMD data from 132 patients who underwent KTx between 2005 and 2021. BMD was assessed using dual-energy X-ray absorptiometry at the time of KTx (T0) and two-years post-KTx (2yT). Patients were categorized into two groups: those who discontinued CS (CS−) within the first-year post KTx and those who continued CS therapy (CS+).</p><h3>Results</h3><p>The mean age at KTx was 52.2 (± 12.6) years, and 62.1% of the patients were male. Overall, BMD increased significantly at the lumbar spine (LS) but decreased at the radius at 2yT, while BMD at the hip site remained stable. CS was discontinued in 44.7% of patients between T0 and 2yT, with an average discontinuation time of 6.3 (± 4.9) months post-KTx. The CS− group showed significant BMD improvements at LS and hip sites. In a multivariate analysis, a higher cumulative CS dose was independently associated with a larger BMD decline.</p><h3>Conclusions</h3><p>CS withdrawal after KTx positively impacts BMD, while higher cumulative CS doses are associated with a greater BMD loss. These findings underscore the importance of minimizing CS exposure to preserve bone health in KTRs.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03018-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}