Aging Clinical and Experimental Research最新文献

{"title":"World congress on osteoporosis, osteoarthritis and musculoskeletal disease","authors":"","doi":"10.1007/s40520-025-03118-0","DOIUrl":"10.1007/s40520-025-03118-0","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1 supplement","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03118-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)","authors":"","doi":"10.1007/s40520-025-03119-z","DOIUrl":"10.1007/s40520-025-03119-z","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1 supplement","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03119-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Prevalence and future estimates of frailty and pre-frailty in a population-based sample of people 70 years and older in norway: the HUNT study","authors":"Ingebjørg Lavrantsdatter Kyrdalen, Heine Bjørn Strand, Geir Selbaek, Pernille Thingstad, Heidi Ormstad, Emiel O. Hoogendijk, Håvard Kjesbu Skjellegrind, Gro Gujord Tangen","doi":"10.1007/s40520-025-03165-7","DOIUrl":"10.1007/s40520-025-03165-7","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03165-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combinations of intrinsic capacity and frailty and their associations with self-rated health in community-dwelling older adults","authors":"Daijo Shiratsuchi,&nbsp;Hyuma Makizako,&nbsp;Shoma Akaida,&nbsp;Yuto Miyake,&nbsp;Ryoji Kiyama,&nbsp;Takayuki Tabira,&nbsp;Mana Tateishi,&nbsp;Rei Otsuka,&nbsp;Toshihiro Takenaka,&nbsp;Takuro Kubozono,&nbsp;Mitsuru Ohishi","doi":"10.1007/s40520-025-03189-z","DOIUrl":"10.1007/s40520-025-03189-z","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background\u0000 <p>Intrinsic capacity (IC) and frailty are distinct but complementary frameworks for understanding the heterogeneity of aging. Although both have been linked to self-rated health, little is known about how their combined status relates to older adults’ health perceptions. This cross-sectional study investigated how combinations of IC and frailty status were associated with self-rated health among community-dwelling older adults.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Method\u0000 <p>Data from 593 participants (mean age: 73.9 years, female: 62.2%) in the 2019 Tarumizu Study were analyzed. <i>IC was evaluated across five key screening domains (cognition</i>,<i> vitality</i>,<i> sensory</i>,<i> locomotion</i>,<i> and psychological) using a 10-point scale</i>, with scores ≥ 9 classified as high IC. Frailty was assessed using the Japanese version of the Cardiovascular Health Study criteria and dichotomized into robustness and frailty (pre-frailty or frailty). Self-rated health was assessed with a four-point item and dichotomized into good or poor. Participants were classified into four groups: robust with high IC, frailty with high IC, robust with low IC, and frailty with low-IC.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results\u0000 <p>Group proportions were: 30.0% (robust with high IC), 23.1% (frailty with high IC), 15.9% (robust with low IC), and 31.0% (frailty with low IC). Multivariable logistic regression showed that only the frailty with low-IC group had significantly greater odds of poor self-rated health compared to the robust with high-IC group (OR = 3.55, 95% CI: 1.34–9.36).</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusions\u0000 <p>Co-occurrence of low IC and frailty was significantly associated with poor self-rated health. These findings suggest that considering IC and frailty may enhance understanding of self-rated health in later life.</p>\u0000 \u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03189-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of ankle torque fluctuations and intramuscular coherence in gait function among older adults","authors":"Akira Yaguchi-Horiuchi,&nbsp;Toshiaki Tsuji,&nbsp;Hiroki Takeuchi,&nbsp;Yoshiharu Yokokawa,&nbsp;Eiji Yamanaka,&nbsp;Ippei Nojima","doi":"10.1007/s40520-025-03188-0","DOIUrl":"10.1007/s40520-025-03188-0","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the relationship between ankle joint function and walking performance in older adults by assessing qualitative ankle functions through torque fluctuation analysis and tibialis anterior (TA) intramuscular coherence during isometric dorsiflexion.</p><h3>Methods</h3><p>Thirty-eight community-dwelling older adults participated in this study. Ankle torque fluctuations and intramuscular coherence were evaluated during a dorsiflexion task at 30% of maximum voluntary torque (MVT). Walking performance was assessed using the 5-meter walk test and the Timed Up and Go (TUG) test. Torque fluctuation indicators, including the coefficient of variation (CV), frequency components, and the primary component calculated by an autoregressive (AR) model, were derived from time-series data. Intramuscular coherence was analyzed in the δ (0–5 Hz) and β (16–35 Hz) frequency bands. Multiple regression analyses adjusted for age were conducted to explore associations between walking performance, torque indicators, and intramuscular coherence.</p><h3>Results</h3><p>The TUG test demonstrated a significant relationship with the AR principal component of torque fluctuations, independent of age (<i>p</i> = 0.031), suggesting that temporal variability in ankle torque contributes to dynamic balance. While no significant relationship was observed between gait function and intramuscular coherence, δ-band coherence showed significant correlations with torque variability (CV, <i>r</i> = 0.598, <i>p</i> &lt; 0.001) and spectral power in both the 0.5–5 Hz (<i>r</i> = 0.62, <i>p</i> &lt; 0.001) and 5–10 Hz (<i>r</i> = 0.544, <i>p</i> = 0.001) bands.</p><h3>Discussion</h3><p>The AR principal component appears to capture kinematic features to motor control and dynamic balance, as evidenced by its association with TUG performance. Furthermore, the relationship between δ-band coherence and torque fluctuations highlights its potential as a maker of neuromuscular function. Although torque fluctuation characteristics and δ-band coherence did not directly correlate with walking speed, they offer valuable insights into the neurophysiological mechanisms underpinning motor control.</p><h3>Conclusion</h3><p>This study demonstrated that temporal variability in ankle torque, as quantified by the AR principal component, contributes to walking ability and dynamic balance in older adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03188-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lipid accumulation product and cognitive impairment: a community-based 4-year prospective cohort study","authors":"Wang Yanyu,&nbsp;Liu Jie,&nbsp;Zhou Rong,&nbsp;Dang Liangjun,&nbsp;Gao Ling,&nbsp;Wei Shan,&nbsp;Shang Suhang,&nbsp;Wang Jin,&nbsp;Wang Jingyi,&nbsp;Qu Qiumin,&nbsp;Deng Yongning","doi":"10.1007/s40520-025-03143-z","DOIUrl":"10.1007/s40520-025-03143-z","url":null,"abstract":"<div><h3>Objectives</h3><p>The relationship between abdominal obesity and cognitive impairment is not fully understood. The lipid accumulation product (LAP) is a convenient and cost-effective indicator for abdominal obesity. In the present study, we investigated the association between the LAP and cognitive impairment in a community-based 4-year prospective cohort study.</p><h3>Methods</h3><p>A total of 1349 (≥ 40 years) participants without cognitive impairment from the village of Xi’an, China were followed for 4 years. Cognitive impairment was diagnosed using a three-step protocol. The LAP was calculated using waist circumference and serum triglyceride levels. Multivariate logistic regression analysis and interaction analysis were used to assess the relationship between the LAP and cognitive impairment.</p><h3>Results</h3><p>The mean age of the participants at baseline was 55.0 ± 9.3 years, 816(60.5%) were female, and 46 (3.4%) were diagnosed as cognitive impairment during the 4-year follow-up. Multivariate logistic regression analysis revealed that lnLAP was not associated with the cognitive impairment in the total population. After stratification by sex, cognitive impairment was associated with lnLAP (OR = 1.85, 95% CI: 1.058–3.257, <i>P</i> = 0.031) in females but not in males (OR = 1.142, 95% CI: 0.503–2.594, <i>P</i> = 0.751). In the females, cognitive impairment was 4.09-fold greater in the highest LAP quartile than that in the lowest LAP quartile (OR = 4.098, 95% CI: 1.135–14.792, <i>P</i> = 0.031).</p><h3>Conclusion</h3><p>High LAP was associated with cognitive impairment in females but not in males. These findings indicate that the effects of abdominal obesity on cognitive impairment may differ between males and females.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03143-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive and emotional benefits of choir singing and their mediating factors across adulthood","authors":"Nella Moisseinen,&nbsp;Alli Haavisto,&nbsp;Silja Heimala,&nbsp;Noelia Martínez-Molina,&nbsp;Boris Kleber,&nbsp;Aleksi J. Sihvonen,&nbsp;Teppo Särkämö","doi":"10.1007/s40520-025-03187-1","DOIUrl":"10.1007/s40520-025-03187-1","url":null,"abstract":"<div><h3>Background</h3><p>Our understanding on how cognitive and socioemotional well-being factors interact throughout adulthood has increased remarkably over the past decades, encouraging the use of cognitively engaging leisure activities, such as music, to promote healthy ageing. Choir singing has attracted particular interest in this regard with its established benefits on socioemotional well-being. Outside the clinical context, however, the cognitive and well-being effects induced by musical activities are often studied separately, leaving it unclear to what extent they interact in contributing to healthy ageing.</p><h3>Aims &amp; methods</h3><p>Using a balanced sample (<i>N</i> = 95) of healthy adults (aged 21–88 years) with neuropsychological test data (verbal fluency, processing speed, executive function, working memory) and questionnaire data (depression and quality of life, QOL), the present study mapped the benefits of choir singing (duration and frequency) on cognitive functions and well-being and their mediating mechanisms across adulthood.</p><h3>Results</h3><p>Choir singing frequency was associated with reduced depressive symptoms, which also mediated effects with QOL. Lifetime duration of choir singing was associated with enhanced episodic memory and verbal fluency, with a mediating effect of semantic verbal fluency on the relationship between choir singing and episodic memory.</p><h3>Discussion &amp; conclusions</h3><p>These findings convey the co-occurrence of singing-associated benefits and characterise shared mechanisms by which these effects interact in promoting healthy ageing.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03187-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive frailty and cardiometabolic risk in middle-aged and older adults: evidence from the UK and China","authors":"Haiyang Yan,&nbsp;Jingjing Lang,&nbsp;Chengfeng Li,&nbsp;Samaneh Eftekhariranjbar,&nbsp;Guoyan Jiang,&nbsp;Jing Lei,&nbsp;Lixin Sun,&nbsp;Carlos J. Toro-Huamanchumo,&nbsp;Zhongyang Guan","doi":"10.1007/s40520-025-03179-1","DOIUrl":"10.1007/s40520-025-03179-1","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive frailty, a novel construct integrating cognitive and physical deficits, is increasingly recognized in aging research.</p><h3>Aims</h3><p>This study aimed to examine the associations between cognitive frailty and cardiometabolic risk in two nationally representative cohorts from China and the United Kingdom.</p><h3>Methods</h3><p>We analyzed data from 7,628 participants in the China Health and Retirement Longitudinal Study (CHARLS) and 4,703 participants from the English Longitudinal Study of Ageing (ELSA), all aged ≥ 50 years. Frailty was assessed using the frailty index (FI) in the main analysis. Cox proportional hazards models were applied to estimate hazard ratios (HRs) for incident cardiometabolic diseases (CMDs), cardiovascular diseases (CVDs), and diabetes. Subgroup and interaction analyses were performed to examine effect modification. Restricted cubic spline (RCS) models were used to assess the shape of the association between FI and cardiometabolic risk. Sensitivity analyses employed competing risk models and the physical frailty phenotype (PFP) as an alternative frailty measure.</p><h3>Results</h3><p>Cognitive frailty was associated with higher risks of CMDs (HR 1.58, 95% CI 1.39–1.79), CVDs (HR 1.64, 95% CI 1.42–1.89), and diabetes (HR 1.39, 95% CI 1.11–1.75). Cognitive impairment alone showed no significant association with these outcomes in the main analysis. Dose–response associations were significant between the FI and CMDs and CVDs among individuals with and without cognitive impairment. Results were consistent across cohorts and robust in sensitivity analyses.</p><h3>Conclusions</h3><p>Cognitive frailty is a consistent predictor of cardiometabolic risk across distinct populations, supporting integrated screening and prevention strategies targeting both cognitive and physical deficits in aging populations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03179-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proportion of participants meeting falls prevention guidelines in an evidence-based community-based exercise program","authors":"Maria Fernanda Fuentes Diaz,&nbsp;Kathryn M. Sibley,&nbsp;Kate Giberson,&nbsp;Martin Sénéchal,&nbsp;Danielle R. Bouchard","doi":"10.1007/s40520-025-03172-8","DOIUrl":"10.1007/s40520-025-03172-8","url":null,"abstract":"<div><h3>Background</h3><p>Although exercise is strongly recommended to prevent falls in older adults (exercise that challenges balance, performed three hours per week on an ongoing basis), few community-based programs meet these recommendations.</p><h3>Aims</h3><p>Assess the proportion of participants meeting fall prevention exercise recommendations in a community-based program and explore how adherence varies by individual characteristics and participation mode (in-person, tele-exercise, or hybrid).</p><h3>Methods</h3><p>A cross-sectional analysis of Zoomers in Balance participants who completed an online questionnaire about their demographic data, mode of participation, and their perceived balance intensity in a 12-week series using the Balance Intensity Scale (1-no effort at all to 5-maximal effort). Weekly attendance was self-reported after each 12-week series, and ongoing participation was assessed using registration data over one year.</p><h3>Results</h3><p>The average perceived balance intensity was 3.2 ± 0.7 (range 1–5), the average attendance was 1.3 ± 0.6 h/week (range 0.2–4.2), and participants attended an average of 3.4 ± 0.6 series/year (range 2–4). None of the participants met all three guidelines. The most fulfilled recommendation was ongoing participation (43%), which was greater in the hybrid (<i>B</i> = 2.68; <i>p</i> &lt; 0.001) and tele-exercise (<i>B</i> = 1.28; <i>p</i> &lt; 0.001) groups compared with the in-person mode. In addition, the mode of participation was associated with meeting one or more guidelines (χ² = 23.05; <i>p</i> &lt; 0.001), without any significant difference between modes.</p><h3>Discussion</h3><p>Offering hybrid participation options could lead to greater adherence to evidence-based guidelines, thereby reducing the risk of falls.</p><h3>Conclusion</h3><p>The proportion of participants meeting fall prevention guidelines in a community-based program is low, with a trend indicating that hybrid options are more effective.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03172-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: “Slow gait speed is associated with frailty, activities of daily living and nutritional status in in-patient pulmonology patients.”","authors":"Qing-Qing Shan,&nbsp;Yangke Li","doi":"10.1007/s40520-025-03128-y","DOIUrl":"10.1007/s40520-025-03128-y","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03128-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}