Aging Clinical and Experimental Research最新文献

{"title":"Correction: The correlation between muscle loss and the severity of vascular stenosis in elderly patients with peripheral artery disease: a retrospective analysis utilizing computed tomography","authors":"Yanyang Zhang, Wenxin Zhao, Zuoguan Chen, Yixuan Wang, Xihao Zhang, Xue Chang, Yongjun Li, Jihong Yang","doi":"10.1007/s40520-025-03044-1","DOIUrl":"10.1007/s40520-025-03044-1","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03044-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gliflozines as add-on to Arni in echocardiographic, sarcopenic and oxidative stress parameters in elderly patients with chronic heart failure","authors":"Giuseppe Armentaro,&nbsp;Velia Cassano,&nbsp;Marcello Magurno,&nbsp;Carlo Alberto Pastura,&nbsp;Marcello Divino,&nbsp;Giandomenico Severini,&nbsp;Domenico Martire,&nbsp;Sofia Miceli,&nbsp;Raffaele Maio,&nbsp;Elisa Mazza,&nbsp;Tiziana Montalcini,&nbsp;Arturo Pujia,&nbsp;Angela Sciacqua","doi":"10.1007/s40520-025-03049-w","DOIUrl":"10.1007/s40520-025-03049-w","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia is common in patients with heart failure (HF) and it is frequently associated with other comorbidities. Sarcopenia has been linked to an increased risk of major adverse cardiovascular events (MACE) in HF patients.</p><h3>Aims</h3><p>The aim of the present study was to evaluate, in a cohort of older adult’s patients affected by HF with reduced ejection fraction (HFrEF) and sarcopenia, already being treated with sacubitril/valsartan, the effect of add-on therapy with SGLT2i on clinical, functional abilities, muscle performance and effects on quality of life.</p><h3>Methods</h3><p>We enrolled 147 outpatients. A simple linear regression analysis was performed to assess the correlation between the change in Cardiac Index (CI) and Short physical performance battery (SPPB) values, expressed as (Δ) between baseline and follow-up (ΔT0-12), and several covariates.</p><h3>Results</h3><p>After 12 months of treatment, we observed an improvement in the inflammatory profile, moreover there was a reduction of the oxidative stress (<i>p</i> &lt; 0.0001) and platelets activation (<i>p</i> &lt; 0.0001) parameters. In addition, there was a significant increase in CI and global longitudinal strain and a statistically significant improvement in cognitive function, as shown by Mini-Mental State examination (MMSE) (<i>p</i> &lt; 0.0001) score and SPPB (<i>p</i> &lt; 0.0001). Considering ΔCI as dependent variation, Δ8-isoprotane resulted the major predictor, justifying 13.3% of its variation. When ΔSPPB was considered as dependent variable, Δ8-Isoprostane was the main predictor of ΔSPPB, justifying 54.6% of its variation.</p><h3>Discussion and conclusions</h3><p>This study demonstrated that the addition of SGLT2i to therapy leads to improvements in echocardiographic and sarcopenia-related parameters and biomarkers of oxidative stress and platelet activation.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03049-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convergence and equating norms between the Telephone Interview for Cognitive Status (TICS), the MMSE and the MoCA in an Italian population sample","authors":"Edoardo Nicolò Aiello,&nbsp;Beatrice Curti,&nbsp;Giulia De Luca,&nbsp;Sara Casartelli,&nbsp;Lorenzo Esposti,&nbsp;Chiara Curatoli,&nbsp;Alice Zanin,&nbsp;Elisa Camporeale,&nbsp;Martina Andrea Sirtori,&nbsp;Federico Verde,&nbsp;Vincenzo Silani,&nbsp;Nicola Ticozzi,&nbsp;Nadia Bolognini,&nbsp;Barbara Poletti","doi":"10.1007/s40520-025-03026-3","DOIUrl":"10.1007/s40520-025-03026-3","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed at testing the convergence and deriving equating norms between the Telephone Interview for Cognitive Status (TICS) and the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) in an Italian population sample.</p><h3>Methods</h3><p>Four-hundred and eighty two healthy Italian native-speaker (300 females; age: 57.8 ± 15.5, <i>range</i> = 20–94; education: 13.1 ± 3.8, <i>range</i> = 5–25) underwent the TICS (<i>range</i> = 1–41), MMSE and MoCA. An additional <i>Delayed Recall</i> of the 10-word list was administered as the last task of the TICS to compute a further total (TICS_&amp;DR; <i>range</i> = 1–51). Convergence between the TICS/TICS_&amp;DR and in-person screeners was tested <i>via</i> Bonferroni-corrected Spearman’s coefficients, whilst equating norms were derived <i>via</i> a Log-linear Smoothing Equipercentile Equating (LSEE) approach. A two one-sided test (TOST) procedure was run to test the equivalence between empirical and LSEE-derived scores.</p><h3>Results</h3><p>TICS scores converged with both MMSE (<i>r</i>_<i>s</i>=0.34; <i>p</i> &lt;.001) and MoCA scores (<i>r</i>_<i>s</i>=0.42; <i>p</i> &lt;.001)– the same being true for the TICS_&amp;DR (MMSE: <i>r</i>_<i>s</i>=0.36; <i>p</i> &lt;.001; MoCA: <i>r</i>_<i>s</i>=0.42; <i>p</i> &lt;.001). Cross-walks were estimated to derive TICS/TICS_&amp;DR scores from the MMSE/MoCA, and vice-versa. The algorithm could not compute the conversions for TICS, MMSE and MoCA scores &lt; 22, &lt;21 and &lt; 14, respectively. TOST procedures revealed that all comparisons yielded equivalence except for those aimed at deriving TICS from MMSE scores and TICS_&amp;DR from both the MMSE and the MoCA.</p><h3>Discussion</h3><p>The Italian TICS validly captures examinees’ cognitive efficiency as measured by MMSE or MoCA; derived cross-walks between the TICS and MMSE/MoCA allows for a flexible use of in-person and telephone-based screeners.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03026-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the 2018 Japan floods and COVID-19 pandemic on cognitive decline among atomic bomb survivors in Hiroshima, Japan: a retrospective cohort study","authors":"Shuhei Yoshida,&nbsp;Daisuke Miyamori,&nbsp;Masanori Ito","doi":"10.1007/s40520-025-03054-z","DOIUrl":"10.1007/s40520-025-03054-z","url":null,"abstract":"<div><h3>Background</h3><p>Atomic bomb survivors (ABSs) in Hiroshima are facing climate change-related natural disasters and emerging infectious diseases. The cognitive function of aging ABSs is vulnerable to the inevitable environmental changes caused by the 2018 Japan floods and COVID-19 pandemic.</p><h3>Aims</h3><p>This study examined the effects of these two disastrous events on cognitive function.</p><h3>Methods</h3><p>This retrospective cohort study included all verified individuals utilizing Long-Term Care Insurance services in Hiroshima Prefecture. The observation period was from January 2018 to December 2022. The participants were divided into three groups: ABSs, welfare recipients (WRs), and others. The objective variable was moderate or severe cognitive deterioration. We performed a difference-in-differences analysis using logistic regression models to investigate the effect of the two disastrous events on cognitive function compared with the effect of the other groups.</p><h3>Results</h3><p>There were 184,252 participants, including 16,306 ABSs (8.8%) and 8,509 WRs (4.6%). The difference-in-differences analysis showed no statistically significant effect of the 2018 Japan floods. The analysis also revealed that moderate cognitive decline among ABSs and WRs decreased during the COVID-19 pandemic (2020, 2021, and 2022). Moreover, severe cognitive decline among ABSs decreased after the onset of the COVID-19 pandemic (2020 and 2021).</p><h3>Discussion</h3><p>Although many older adults experienced cognitive exacerbations during the COVID-19 pandemic, ABSs had a lower risk of cognitive decline than those of non-WRs. However, no significant changes were observed during the 2018 Japan floods.</p><h3>Conclusions</h3><p>ABSs had a reduced risk of cognitive decline during the pandemic compared with that of the other groups.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03054-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal effects of diet quality on healthy aging - Focus on cardiometabolic health: findings from the Canadian longitudinal study on aging (CLSA)","authors":"Farhad Vahid,&nbsp;Piotr Wilk,&nbsp;Torsten Bohn","doi":"10.1007/s40520-025-03058-9","DOIUrl":"10.1007/s40520-025-03058-9","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension, a major concern for older adults, contributes to morbidity and mortality by increasing the risk of cardiovascular disease, stroke, kidney dysfunction, and cognitive decline. A healthy diet plays a vital role in limiting chronic disease progression in aging populations.</p><h3>Aim</h3><p>This study investigated the association between diet quality and healthy aging, focusing on blood pressure measurements (BPMs), using the Canadian Longitudinal Study on Aging (CLSA).</p><h3>Methods</h3><p>Participants aged 45–85 years at baseline were followed for up to nine years. Mediterranean diet score (MDS) was determined based on the validated short diet questionnaire (SDQ). BP and mean arterial pressure (MAP) were measured at baseline (2010), follow-up 1 (2015), and follow-up 2 (2018). Linear regression models (LRMs), linear mixed-effects models (LMMs), and latent change score models (LCSMs) examined the associations and longitudinal effect between MDS and BPMs, adjusted for potential confounders. Individuals who participated in all three waves (<i>n</i> = 25,377) were included.</p><h3>Results</h3><p>Fully adjusted LRMs showed significant (<i>p</i> &lt; 0.001) inverse associations between MDS and all BPMs across all time points, e.g., 1 unit increase in the MDS (min0-max50) was associated with a 0.058 mmHg decrease of diastolic BP (DBP) (β=-0.058), 0.052 mmHg systolic BP (SBP) (β=-0.052), and 0.056 mmHg MAP (β=-0.056). LCSMs indicated that a 1-unit higher baseline MDS was significantly associated with 0.090 mmHg reductions in DBP at follow-up 2 (β=-0.090,<i>p</i> &lt; 0.001), 0.078 mmHg for SBP (β=-0.078,<i>p</i> = 0.002) and 0.076 mmHg for MAP (β=-0.076,<i>p</i> = 0.003). Changes in MDS during follow-ups showed no consistent significant associations with BPMs at follow-up 1 or 2.</p><h3>Discussion and conclusion</h3><p>Higher MDS was associated with lower BPMs over time. This study highlights the role of diet quality in healthy aging and mitigating cardiometabolic risk in older adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03058-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of comprehensive geriatric assessment in older patients affected by knee osteoarthritis: an exploratory randomized controlled trial","authors":"Nicola Veronese,&nbsp;Anna Fazzari,&nbsp;Eleonora Santangelo,&nbsp;Candela Iommi,&nbsp;Pinar Soysal,&nbsp;Carlo Custodero,&nbsp;Lena Pickert,&nbsp;Maria Cristina Polidori,&nbsp;Nicoleta Stolniceanu,&nbsp;Helena Michalkova,&nbsp;Eva Topinkova,&nbsp;Alberto Pilotto,&nbsp;Mario Barbagallo","doi":"10.1007/s40520-025-03061-0","DOIUrl":"10.1007/s40520-025-03061-0","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to assess the effectiveness of Comprehensive Geriatric Assessment (CGA) compared to standard of care in improving pain, physical function, and stiffness in older adults with knee osteoarthritis (OA) over six months. Secondary outcomes included multidimensional frailty and quality of life.</p><h3>Design</h3><p>An exploratory, multicentre, randomized controlled trial (RCT).</p><h3>Setting</h3><p>Five European geriatric centres in Italy, Germany, Turkiye and the Czech Republic.</p><h3>Participants</h3><p>Seventy older adults (mean age 76.1 ± 6.8 years; 80% female) with knee OA (Kellgren-Lawrence Grades 1–2) were randomized into two groups: CGA (<i>n</i> = 35) or standard of care (<i>n</i> = 35).</p><h3>Intervention</h3><p>The CGA group underwent a multidimensional geriatric assessment and intervention, identifying impairments and tailoring interventions accordingly, while the control group received standard of care.</p><h3>Main outcome measures</h3><p>The primary endpoint was improvement in pain, stiffness, and functional limitations measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) over six months. Secondary outcomes included changes in multidimensional frailty (Multidimensional Prognostic Index, MPI), quality of life (SF-36), and adherence to interventions.</p><h3>Results</h3><p>The CGA group showed a non-significant improvement in total WOMAC scores (-4.49 ± 3.40, <i>p</i> = 0.19), with slight reductions in pain (-1.12 ± 0.96) and functional limitations (-3.26 ± 2.21). MPI slightly improved (-0.02 ± 0.04, <i>p</i> = 0.69), but no significant changes were observed in SF-36 scores. No falls, hospitalizations, or severe adverse events were reported.</p><h3>Conclusions</h3><p>CGA may offer potential benefits for managing knee OA in older adults, particularly for pain and function, though statistical significance was not achieved. Larger studies with longer follow-up are warranted to confirm these findings.</p><h3>Trial registration</h3><p>ClinicalTrials.gov Identifier: NCT05659979.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03061-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the number of teeth and frailty among older adults: a systematic review and meta-analysis","authors":"Xiao-Ming Zhang,&nbsp;Simin Cao,&nbsp;Liting Teng,&nbsp;Xiaohua Xie,&nbsp;Xinjuan Wu","doi":"10.1007/s40520-025-03053-0","DOIUrl":"10.1007/s40520-025-03053-0","url":null,"abstract":"<div><h3>Background</h3><p>Tooth loss is common among the elderly and often correlates with aging. Existing studies on the link between tooth loss and frailty in older adults yield inconsistent results. This systematic review and meta-analysis aims to clarify the relationship.</p><h3>Methods</h3><p>A comprehensive search of PubMed, Web of Science, Embase, and Cochrane Library was conducted to find observational studies on tooth count and frailty in older adults. Study quality was assessed using the Newcastle-Ottawa scale. Heterogeneity was evaluated using Cochran’s Q and I² statistics, and subgroup analyses identified factors influencing outcomes. Publication bias and sensitivity analysis confirmed result stability.</p><h3>Results</h3><p>From 1,903 articles, 22 comprising 25 studies with 36,406 participants were included. The meta-analysis showed a pooled odds ratio (OR) of 0.98 (95% CI: 0.97 − 0.99) for tooth count and frailty. Individuals with 20 or fewer teeth had a higher risk of frailty (pooled OR = 1.99, 95% CI: 1.57 − 2.53). The highest frailty risk was observed in Japan (pooled OR = 3.02), followed by China (2.27), the UK and USA (1.90), and other regions (1.25). Subgroup analyses revealed no significant differences by country, study design, setting, adjustment model, or frailty assessment tool (<i>P</i> &gt; 0.05).</p><h3>Conclusions</h3><p>There is a significant association between tooth count and frailty, particularly in those with 20 or fewer teeth. Policymakers should prioritize oral health within aging populations by promoting early preventive care and education to mitigate frailty risk. Robust, large-scale studies are needed to guide evidence-based interventions and public health policy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03053-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of serum irisin, 25(OH)D3 and albumin in older adults with chronic disease and sarcopenia","authors":"Yuxia Ma,&nbsp;Yi Liu,&nbsp;Jiachuang Zheng,&nbsp;Zhixia Zheng,&nbsp;Jingjing Li","doi":"10.1007/s40520-025-03051-2","DOIUrl":"10.1007/s40520-025-03051-2","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia, characterized by progressive muscle mass and strength decline, poses a significant health challenge among older adults, especially those with chronic diseases. Our study aims to evaluate the combined diagnostic potential of irisin, 25(OH)D3, and albumin for sarcopenia in older patients with chronic conditions.</p><h3>Methods</h3><p>A cohort of 393 older patients with chronic diseases, including 117 diagnosed with sarcopenia were included. Fasting blood samples were collected, and serum biomarkers (25(OH)D3, albumin, and irisin) were measured using automated biochemical analyzers and enzyme-linked immunosorbent assay to evaluate nutritional and muscle-related parameters.</p><h3>Results</h3><p>The prevalence of sarcopenia was higher among patients aged 80 or older compared to younger age groups in our study population. Strong associations were observed between sarcopenia and osteoporosis, tumors, and risk of malnutrition. Serum irisin, 25(OH)D3, and albumin levels were significantly lower in sarcopenic patients. Individual biomarkers displayed diagnostic potential, and a combined biomarker test showed superior accuracy. Multivariate logistic regression identified age, osteoporosis, malnutrition, and fatigue as independent risk factors, while higher serum biomarker levels correlated with reduced sarcopenia risk. Positive correlations were observed between serum biomarkers and sarcopenia severity indicators.</p><h3>Conclusions</h3><p>This study highlights the potential of irisin, 25(OH)D3, and albumin as diagnostic and prognostic tools for sarcopenia in older patients with chronic diseases, contributing to early detection and intervention strategies to enhance their quality of life.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03051-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial","authors":"Elena Rolandi,&nbsp;Alessandra Dodich,&nbsp;Sara Mandelli,&nbsp;Nicola Canessa,&nbsp;Clarissa Ferrari,&nbsp;Federica Ribaldi,&nbsp;Giulio Munaretto,&nbsp;Claudia Ambrosi,&nbsp;Roberto Gasparotti,&nbsp;Davide Violi,&nbsp;Sandro Iannaccone,&nbsp;Alessandra Marcone,&nbsp;Andrea Falini,&nbsp;Giovanni B. Frisoni,&nbsp;Samantha Galluzzi,&nbsp;Chiara Cerami,&nbsp;Enrica Cavedo","doi":"10.1007/s40520-025-03062-z","DOIUrl":"10.1007/s40520-025-03062-z","url":null,"abstract":"<div><h3>Background</h3><p>Multidomain lifestyle interventions are a promising approach to prevent cognitive decline, but their effects in subjective cognitive decline (SCD) remain controversial. We investigated the effects of lifestyle interventions on cognition and brain integrity in these at-risk individuals.</p><h3>Methods</h3><p>One-hundred twenty-eight older adults with SCD were randomly assigned to either Active Control Intervention (ACI), i.e. health education; Partial Intervention (PI), i.e. tramiprosate supplementation (100 mg/die) and dietary advice; or Multilevel Intervention (MI), i.e. PI <i>plus</i> computerized cognitive training and physical exercise, for one year. Neuropsychological assessment and MRI were performed at baseline and at 1-year follow-up. Analyses of covariance were used to measure the effects of interventions on predefined outcomes.</p><h3>Results</h3><p>The MI group significantly improved in attention-executive functioning (p = 0.003) compared to ACI (Cohen’s d: 0.47, 95% CI 0.13–0.79). In addition, depressive symptoms (Cohen’s d: – 0.48, 95% C.I. – 0.81 to – 0.14) and memory concerns (Cohen’s d: – 0.77, 95% C.I. – 1.12 to – 0.41) decreased in the MI and PI respectively, relative to the ACI. The MI group also showed increased resting-state (i.e., intrinsic) brain activity in the right fronto-parietal executive network. No significant intervention effects on brain structural or vascular outcomes were found.</p><h3>Conclusion</h3><p>The study shows that a multidomain lifestyle intervention can enhance attention-executive function, ameliorate depressive symptoms and increase functional connectivity in SCD. These findings support the role of lifestyle interventions in public health strategies to mitigate cognitive decline risk.</p><h3>Trial registration</h3><p>The trial has been registered at the United States National Library of Medicine at the National Institutes of Health Registry of Clinical Trials under the code NCT04744922 on December 9th, 2017 (https://www.clinicaltrials.gov/ct2/show/NCT03382353).</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03062-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between cerebral microhemorrhages and cognitive decline across Alzheimer’s continuum","authors":"Homayoon Khaledian,&nbsp;Ali Julaee Rad,&nbsp;Pardis Barjisi,&nbsp;Parsa Saberian,&nbsp;Mehrdad Mozafar,&nbsp;Sahar Ghahramani,&nbsp;Mohammad Sadeghi,&nbsp;Mahsa Mayeli,&nbsp;Seyed Mohammad Amin Alavi,&nbsp;Soorin Berenjian,&nbsp;Shaghayegh Karami,&nbsp;Mohadeseh Andalibian","doi":"10.1007/s40520-025-02988-8","DOIUrl":"10.1007/s40520-025-02988-8","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the associations between cerebral microhemorrhages (CMH) and cognitive decline across the Alzheimer’s dementia continuum.</p><h3>Methods</h3><p>Using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, we studied 619 participants, categorized into 221 cognitively normal (CN) participants, 281 patients with mild cognitive impairment (MCI), and 117 patients with Alzheimer’s disease (AD). CMH prevalence and distribution were determined using T2-weighted magnetic resonance imaging (MRI), focusing on the frontal, occipital, and parietal subcortical regions of interest (ROIs).Clinical dementia rating scale sum of boxes (CDR-SB) and mini-mental state examination (MMSE) were used for diagnosis and composite cognitive scores regarding visuospatial abilities, language, memory, and executive functions were used as outcome variables. Age, gender, and APOE ε4 positivity status were used as covariates.</p><h3>Results</h3><p>The AD group displayed significantly elevated tau and P-tau levels compared to MCI and CN groups (<i>p</i> &lt; 0.001). APOE ε4 positivity was 67.5% in the AD group, surpassing the 50.2% in MCI and 29% in CN individuals (<i>p</i> &lt; 0.001). Cognitive assessments revealed that the AD group’s CDR-SB score and MMSE both significantly differed from these scores in the MCI and CN groups (<i>p</i> &lt; 0.001). Overall, CMH prevalence was 27.7%, with a predominant distribution in the frontal subcortical ROIs. MCI subjects with CMH showed notably diminished ADNI Visuospatial Composite Scores compared to those without CMH. Age significantly predicted CMH in CN and MCI (<i>p</i> &lt; 0.05). In AD participants, APOE ε4 heterozygotes (<i>p</i> = 0.02) and homozygotes (<i>p</i> = 0.01) hadincreased CMH likelihood.</p><h3>Conclusion</h3><p>CMHs are significantly associated with cognitive decline in patients with MCI. This association is more prominent in regard to the decline in visuospatial abilities.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02988-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}