Aging Clinical and Experimental Research最新文献

{"title":"The distribution of the frailty index among different arthritis patients and the association between the frailty index and mortality in rheumatoid arthritis patients among U.S. adults (results from NHANES 1999-2018).","authors":"Shi-Chao Tang, Lei Jin, Yong-Qi Hu, Jun-Feng Peng, Yan-Qing Wang, Chong Shao, Yu Liu","doi":"10.1007/s40520-025-03091-8","DOIUrl":"10.1007/s40520-025-03091-8","url":null,"abstract":"<p><strong>Background: </strong>We conducted to examine the prevalence of frailty among different arthritis populations and to elucidate the associations between frailty and all-cause and cause-specific mortality among rheumatoid arthritis (RA) in the American adults.</p><p><strong>Method: </strong>National Health and Nutrition Examination Survey (NHANES) database spanning 1999 to 2018 was collected, supplemented with pertinent mortality records from the U.S. National Death Index (NDI) up to December 31, 2019. The Frailty Index defined by Searle was adopted. Different types of arthritis include: RA, Osteoarthritis (OA), Psoriatic Arthritis (PsA), and others. Statistical methods mainly included maximum selected rank statistics, univariate and multivariate COX regression models, and Restricted Cubic Spline (RCS).</p><p><strong>Results: </strong>The frailty indices of different arthritis populations were 0.24, 0.21, 0.21, and 0.20, respectively. The cut-off value for the frailty index was 0.3. Compared to those with a lower frailty index, participants with a higher frailty index exhibited higher risks of all-cause mortality (HR = 2.11, 95% CI 1.70-2.62), heart disease mortality (HR = 2.38, 95% CI 1.53-3.70), lower respiratory disease mortality (HR = 3.79, 95% CI 1.62-8.88), and influenza and pneumonia mortality (HR = 6.08, 95% CI 2.12-17.42). Frailty-associated all-cause mortality risks increased with age among different age groups.</p><p><strong>Conclusion: </strong>Frailty was particularly pronounced among RA patients. Relatively high frailty index could predict higher all-cause and cause-specific mortality among RA adults in America, and the all-cause mortality related to frailty increased with age. Frailty index could be utilized as a prognostic marker in RA management. Timely interventions are paramount for optimizing patient outcomes.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"186"},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review.","authors":"Konstantinos Prokopidis, Alyssa N Varanoske, Nicola Veronese, Ben Kirk, Konstantinos Katsikas Triantafyllidis, Christoforos D Giannaki, Pinelopi S Stavrinou, David D Church, Gustavo Duque","doi":"10.1007/s40520-025-03097-2","DOIUrl":"10.1007/s40520-025-03097-2","url":null,"abstract":"<p><strong>Background: </strong>Intermuscular (InterMAT) and intramuscular (IntraMAT) adipose tissues are key contributors to skeletal muscle function and metabolic health.</p><p><strong>Objective: </strong>In this systematic review, we aimed to investigate the impact of different types of exercise with or without a hypocaloric diet on reducing InterMAT and IntraMAT in various muscle tissues.</p><p><strong>Method: </strong>A literature search was performed via PubMed, Cochrane Library, Scopus, and Web of Science from inception until February 2025. Eligible RCTs examined the effects of exercise compared to control in adults > 18 years. A narrative synthesis was employed with a registered protocol at CRD42024511531.</p><p><strong>Results: </strong>Nineteen RCTs were included in the systematic review. Resistance and aerobic exercise alongside a hypocaloric diet displayed inconsistent results in reducing thigh InterMAT. Under non-hypocaloric conditions there were consistently no alterations of InterMAT and IntraMAT irrespective of muscle tissue. When concurrent exercise was followed, no statistically significant changes were observed with or without a hypocaloric diet on thigh InterMAT and IntraMAT. Results were overall lacking in regards to resistance or aerobic exercise and IntraMAT due to the low number of studies.</p><p><strong>Conclusion: </strong>There is potential in reducing thigh InterMAT following resistance or aerobic exercise combined with a hypocaloric diet, although inconsistencies among studies were presented. However, irrespective of exercise type, under non-hypocaloric conditions no benefits were conferred on InterMAT and IntraMAT of any muscle tissue. Further research is warranted to determine the effects of different exercise intensities employing an adequate dietary and hypocaloric control on skeletal muscle InterMAT and particularly IntraMAT.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"183"},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of a new digital version of the MPI-SVaMA (MPI-SVaMA Digit) in predicting short- and long-term mortality in community-dwelling older people.","authors":"Wanda Morganti, Emanuele Seminerio, Nicola Veronese, Romina Custureri, Carolina Massone, Peter Fielding, Maria Chiara Corti, Stefania Maggi, Luigi Ferrucci, Alberto Pilotto","doi":"10.1007/s40520-025-03098-1","DOIUrl":"10.1007/s40520-025-03098-1","url":null,"abstract":"<p><strong>Background: </strong>The Multidimensional Evaluation of Elderly Person Form (SVaMA) is the official Comprehensive Geriatric Assessment (CGA) tool in most Italian regions for assessing medical, social, and functional needs of community-dwelling older people and developing an integrated care plan to meet them. The Multidimensional Prognostic Index (MPI) is a validated CGA-based tool for predicting mortality, other negative health outcomes and assessing multidimensional frailty. SVaMA's wide diffusion in clinical practice prompted the development of an MPI version based on its data (MPI-SVaMA).</p><p><strong>Aims: </strong>Assessing the usefulness in predicting mortality of a new digital version of the MPI-SVaMA (MPI-SVaMA Digit) through a simpler model.</p><p><strong>Methods: </strong>In this retrospective cohort study, 12.020 community-dwelling older people (≥ 65 years) who underwent the SVaMA in Veneto, Italy were included. One-month and one-year mortality rates were retrieved from Registry Offices. The MPI-SVaMA Digit was obtained by assigning a risk category to each domain assessed in the SVaMA. Accuracy and precision were assessed using Area Under the Curve (AUC) and concordance index (C-index). The association between MPI-SVaMA Digit and mortality was evaluated through Cox regression analysis.</p><p><strong>Results: </strong>The MPI-SVaMA Digit showed good accuracy and precision in predicting 1-month (AUC = 0.78; 95%CI 0.75-0.81, C-index = 0.78 95%CI 9.75-0.81) and 1-year mortality (AUC = 0.77; 95%CI 0.76-0.78, C-index = 0.72 95%CI 0.71-0.74). People at moderate and severe risk of multidimensional frailty showed, respectively a 4-fold and 12-fold increased mortality risk than the group at mild risk.</p><p><strong>Conclusion: </strong>The new MPI-SVaMA Digit is an accurate prognostic tool for short- and long-term mortality useful to address clinical and organizational demands in community-dwelling older people.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"184"},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye movement parameters as biomarkers for diagnosis and levodopa responsiveness in patients with Parkinson's disease.","authors":"Qibing Luo, Ziqi Gao, Qi Qi, Siming Rong, Rui Yang, Chentao He, Mengfei Cai, Piao Zhang, Yuhu Zhang","doi":"10.1007/s40520-025-03089-2","DOIUrl":"10.1007/s40520-025-03089-2","url":null,"abstract":"<p><strong>Background: </strong>Abnormalities in characteristic eye movements have been identified in Parkinson's disease (PD) patients.</p><p><strong>Aim: </strong>To determine if eye movement parameters can serve as biomarkers for diagnosing PD and predicting therapeutic responses to levodopa.</p><p><strong>Methods: </strong>We enrolled 128 PD patients and 28 healthy controls, assessing eye movements before and after levodopa administration.</p><p><strong>Results: </strong>Specific eye movement parameters robustly differentiated PD patients from controls, with an AUC of 0.856, and maintained robustness post-levodopa. Correlations were found between changes in eye movement parameters and motor symptom improvements, leading to a predictive model for levodopa responsiveness with an AUC of 0.783.</p><p><strong>Discussion and conclusions: </strong>Eye movement assessments offer an objective tool for PD diagnosis and levodopa responsiveness prediction.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"182"},"PeriodicalIF":3.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimagrumab and sarcopenia.","authors":"Busra Can, Asli Tufan","doi":"10.1007/s40520-024-02915-3","DOIUrl":"10.1007/s40520-024-02915-3","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"180"},"PeriodicalIF":3.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vigorous physical activity does not lower all-cause and cardio-cerebrovascular mortality more than moderate physical activity in aged hypertensive patients.","authors":"Cairong Li, Zhi Zhang, Jinjin Zhu, Changqing Du, Hongfeng Jin, Beimi Jiang, Zhikui Sun, Jiangjie Lou, Xiaowei Liu","doi":"10.1007/s40520-025-03093-6","DOIUrl":"10.1007/s40520-025-03093-6","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is becoming more common worldwide, with a significant portion of the adult population affected and expected to grow substantially in the coming decades. Physical activity is widely recognized as an essential non-pharmacological intervention for managing hypertension. However, there remains controversy regarding the optimal intensity of physical activity, particularly for aged with hypertension.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (1999-2018) were analyzed, including 5,461 hypertensive participants aged 65 and older. Participants were categorized into three groups based on their physical activity levels: sedentary, moderate, and vigorous. Mortality rates, including all-cause, cardiovascular, and cardio-cerebrovascular mortality, were compared across these groups using multivariate logistic regression models, adjusting for potential confounders.</p><p><strong>Results: </strong>The study included 5,461 hypertensive participants with a mean age of 74.36 years, split almost evenly by gender. The sedentary group had the highest mean age (74.76 years), while the vigorous activity group was the youngest (72.64 years). The majority (59.85%) were non-Hispanic White, and nearly half (49.86%) had lower incomes. Mortality rates were highest in the sedentary group (37.63% all-cause, 11.01% cardiovascular, 13.19% cardio-cerebrovascular). The vigorous activity group showed no significant reduction in mortality compared to the moderate activity group.</p><p><strong>Conclusions: </strong>Vigorous physical activity does not confer additional mortality benefits over moderate physical activity in older hypertensive patients and may even pose risks in certain subgroups. These findings suggest that moderate physical activity may be more appropriate for this population, emphasizing the need for individualized exercise recommendations.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"181"},"PeriodicalIF":3.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory frailty index improves prediction of in-hospital falls among older adults.","authors":"Hirotaka Nakashima, Takahiro Imaizumi, Hitoshi Komiya, Akemi Morohashi, Kazuhisa Watanabe, Chisato Fujisawa, Yosuke Yamada, Yoshimasa Nagao, Hiroyuki Umegaki","doi":"10.1007/s40520-025-03090-9","DOIUrl":"10.1007/s40520-025-03090-9","url":null,"abstract":"<p><strong>Aims: </strong>To explore the association between Frailty Index based on laboratory tests (FI-lab) and in-hospital fall risk in older adults, and to explore whether incorporating FI-lab improves the predictive accuracy of a traditional fall risk prediction tool.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using electronic medical records from patients aged ≥ 60 years who were admitted to Nagoya University Hospital in 2020. We assessed fall risk using the St. Thomas's Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY). We calculated FI-lab based on 35 common laboratory parameters tested on admission. Each fall was reported prospectively by nurses through computer-based incident report forms. The relationship between FI-lab and in-hospital falls was analyzed using multivariate binomial logistic regression. Predictive performance was compared using the area under the receiver operating characteristic curve (AUROC) and net reclassification improvement (NRI). Missing data were not imputed and internal validation used 1000-bootstrap optimism-correction.</p><p><strong>Results: </strong>Data for 5984 patients were included (mean age 73 years, 63.5% male). The mean FI-lab score was 0.31 ± 0.16. Falls occurred in 175 patients (2.9%) during a median hospital stay of 9 days. FI-lab was associated with falls independently of STRATIFY. Adding FI-lab to STRATIFY significantly improved its predictive accuracy, increasing AUROC from 0.674 to 0.715 (p = 0.018), with NRI of 0.413 (p < 0.001). Calibration slope after internal validation was 0.97.</p><p><strong>Conclusions: </strong>FI-lab on admission was independently associated with in-hospital fall risk and improved the predictive ability of STRATIFY. FI-lab could be a valuable component in more accurate fall prediction.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"179"},"PeriodicalIF":3.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between weight change in adulthood and risk of frailty among middle-aged and older adults: a cross-sectional study from NHANES.","authors":"Linsen Li, Junkun Zhan, Yanjiao Wang, Yi Wang, Shuang Li, Youshuo Liu","doi":"10.1007/s40520-025-03082-9","DOIUrl":"10.1007/s40520-025-03082-9","url":null,"abstract":"<p><strong>Background: </strong>There is limited research on the relationship between weight changes and the risk of frailty. This study aimed to investigate the association between weight changes throughout adulthood and frailty risk among middle-aged and older adults using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>We analyzed data from 12,009 adults aged 50 years and older from the 2007-2018 NHANES. Weighted logistic regression models were used to examine the associations between weight changes and frailty risk. In addition, restricted cubic splines (RCS) were applied to explore potential non-linear relationships.</p><p><strong>Results: </strong>Over the course of adulthood, participants in the categories of maximum overweight, obese to non-obese, non-obese to obese, and stable obese demonstrated a significantly higher risk of frailty compared to the stable normal. The corresponding odds ratios were of 1.28 (95% CI: 1.07, 1.55), 2.50 (95% CI: 1.56, 4.01), 2.57 (95% CI: 2.15, 3.08), and 5.26 (95% CI: 4.03, 6.85), respectively. Additionally, weight loss of ≥ 2.5 kg within the 10 years prior to recruitment was associated with increased frailty risk, with an odds ratio of 1.24 (95% CI: 1.03, 1.50).</p><p><strong>Conclusion: </strong>This study found that patterns of weight change, including maximum overweight, obese to non-obese, non-obese to obese, and stable obesity, were significantly associated with an increased risk of frailty. Weight loss from middle to late adulthood and weight gain throughout adulthood were significant associated with an increased risk of frailty. These findings highlight the importance of maintaining a healthy body weight throughout adulthood.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"178"},"PeriodicalIF":3.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of behavioral patterns on accelerated aging in the UK biobank.","authors":"Jinhua Zhou, Xin Meng, Fan Wang, Yun Zhong, Tongtong Zhang, Rui Mao, Hu Zhang","doi":"10.1007/s40520-025-03074-9","DOIUrl":"10.1007/s40520-025-03074-9","url":null,"abstract":"<p><strong>Background: </strong>Biological Age Acceleration (BAA), as quantified by epigenetic clocks, is a well-established biomarker for mortality and age-related morbidity. This study aimed to investigate the independent and combined associations of sleep duration, sedentary behavior, and physical activity with BAA risk.</p><p><strong>Methods: </strong>Leveraging the UK Biobank cohort, we conducted multiple linear regression analyses to assess the relationships between modifiable lifestyle factors and BAA. Nonlinear associations were evaluated using restricted cubic spline models, while causal inference was reinforced through two-sample Mendelian randomization analyses.</p><p><strong>Results: </strong>A total of 241,125 participants (mean [SD] age, 55.99 [8.11] years; 124,029 female) were included in this analysis. Distinct non-linear patterns were discernible in the relationship of sedentary behavior, sleep duration, and physical activity with BAA risk. Sleep duration was correlated with BAA in a U-shaped pattern, with an apex of benefit at 7 h nightly. Leisure-time physical activity related to BAA in an L-shaped curve, suggesting limited benefits beyond a threshold of activity. Conversely, sedentary behavior exhibited a linear relationship with BAA, characterized by a progressively escalating risk. Interaction analyses revealed that a combination of 7 h of sleep, moderate-to-high leisure-time physical activity, and minimal sedentary behavior offered substantial protection against BAA (β = -0.775; 95% Confidence Interval, -0.849 to -0.702). These findings were substantiated by subsequent Mendelian randomization analysis.</p><p><strong>Conclusions: </strong>Our findings demonstrate that modifiable lifestyle patterns-specifically increased leisure-time physical activity, optimized sleep duration, and reduced sedentary behavior-are significantly associated with attenuated biological aging. These results suggest behavioral modifications may represent viable strategies for decelerating aging.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"177"},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of plant-based diets in relation to all-cause and cardiovascular disease mortality in US adults with sarcopenia: a population-based study.","authors":"Shaoyang Liu, Lei Zhang, Shuo Ge, Jixiang Shi, Jianjun Qiu, Xiaoxu Ge, Qingge Fu","doi":"10.1007/s40520-025-03080-x","DOIUrl":"10.1007/s40520-025-03080-x","url":null,"abstract":"<p><strong>Purpose: </strong>This observational study aimed to examine the relationship between three plant-based diet (PBD) indices and the risk of all-cause and cardiovascular disease (CVD) mortality in patients with sarcopenia.</p><p><strong>Methods: </strong>Adults with sarcopenia from the 1999-2006 and 2011-2018 National Health and Nutrition Examination Survey were included. A total plant-based diet index (PDI), a healthful PDI (hPDI) and an unhealthful PDI (uPDI) were created based on 17 food groups and were assessed for their associations with all-cause and CVD mortality risk using Cox proportional hazards regression models, restricted cubic spine analysis, and interaction analysis.</p><p><strong>Results: </strong>A total of 684 (222 from CVD) deaths were documented in 2218 participants (mean age 51.36 years; 53.90% men) during a median follow-up of 117 months. Compared with the lowest quartile, the hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality in the highest quartile were 0.49 (0.33-0.75) for total PDI, 0.27 (0.19-0.39) for hPDI, and 1.85 (1.30-2.65) for uPDI. Similarly, for CVD mortality, the HRs and 95% CIs in the highest quartile were 0.29 (0.12-0.69) for total PDI, 0.30 (0.18-0.50) for hPDI, and 2.65 (1.21-5.77) for uPDI, compared to the lowest quartile. The protective associations of hPDI with all-cause and CVD mortality were more pronounced in participants younger than 45 years.</p><p><strong>Conclusion: </strong>Higher adherence to PDI and hPDI is associated with a lower risk of all-cause and CVD mortality, whereas higher adherence to uPDI is linked to an increased risk of mortality in US adults with sarcopenia.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"176"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}