Aging Clinical and Experimental Research最新文献

{"title":"The association between playing Ma-jong, chess, and card games and cognitive function improvement in middle-aged and elderly Chinese: cross-sectional evidence from CHARLS","authors":"Yingshi Du,&nbsp;Gejing Liu,&nbsp;Jing Wang,&nbsp;Jinli Chen,&nbsp;Jinggang Yang","doi":"10.1007/s40520-025-03103-7","DOIUrl":"10.1007/s40520-025-03103-7","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between participation in Ma-jong, chess, and card games (PMCC) and cognitive function improvement among middle-aged and elderly adults in China is not well-established. This study aims to investigate the potential association between PMCC participation and cognitive function improvement in this demographic, using data from the China Health and Retirement Longitudinal Study (CHARLS).</p><h3>Methods</h3><p>Data from the 2018 wave of CHARLS were analyzed. Participants aged 45 and above who met the inclusion criteria were categorized based on their participation in PMCC activities. Cognitive function was assessed using a composite score incorporating episodic memory and mental status, alongside CESD-10 and CSI-D measures. Cross-sectional associations between PMCC engagement and cognitive function were examined using t-tests, chi-square tests, and one-way ANOVA. Group differences were assessed to evaluate the relationship between activity frequency and cognitive outcomes.</p><h3>Results</h3><p>A total of 19,816 participants (47.13% male; mean age 61.7 ± 10.3 years) were included in the study. The cognitive function related scores were significantly higher in the PMCC group (16.45%) compared to the non-PMCC group (83.55%) (<i>P</i> &lt; 0.001). Moreover, the findings revealed significant associations between PMCC frequency and overall cognitive function scores (<i>P</i> &lt; 0.001).</p><h3>Conclusions</h3><p>PMCC activities are associated with cognitive function improvement in middle-aged and elderly adults in China. These findings suggest that engaging in PMCC activities could serve as a potential protective factor for enhancing cognitive health in this population, providing a basis for incorporating PMCC into strategies aimed at promoting cognitive well-being and healthy aging.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03103-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing SARS-CoV-2 case numbers and clustering to predict a nursing home outbreak","authors":"Yasin Abul,&nbsp;Kevin McConeghy,&nbsp;Frank DeVone,&nbsp;Christopher Halladay,&nbsp;Stefan Gravenstein,&nbsp;James Rudolph","doi":"10.1007/s40520-025-03155-9","DOIUrl":"10.1007/s40520-025-03155-9","url":null,"abstract":"<div><p>The COVID-19 pandemic devastated nursing homes, highlighting the urgent need for effective outbreak control measures. This study analyzed twice-weekly PCR surveillance data from 134 Veteran Affairs Community Living Centers (December 2021-June 2022) to identify early predictors of SARS-CoV-2 outbreaks. Among 16,353 residents (mean age 74, 96% male, 68% white), we identified 1,868 infections and evaluated neighborhood ward-level case counts and their association with subsequent infections over two-week periods. Epidemic unit-days with no initial cases had an 87.49% likelihood of remaining case-free, while those with ≥ 4 initial cases demonstrated a 38.5% probability of developing ≥ 4 additional cases. These findings indicate that early case clusters strongly predict larger outbreaks, underscoring the importance of rapid detection and intervention. Study limitations include demographic homogeneity and reliance on frequent PCR testing, potentially limiting generalizability. This research provides a valuable framework for refining outbreak definitions and improving infection control strategies for respiratory virus outbreaks in nursing homes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03155-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of temporalis muscle thickness and frailty in an Australian memory clinic cohort","authors":"Andrew L. H. Huynh,&nbsp;Sophia Avramoudas,&nbsp;James Andrews,&nbsp;Nan Jordan,&nbsp;Paul Yates","doi":"10.1007/s40520-025-03173-7","DOIUrl":"10.1007/s40520-025-03173-7","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia and frailty are associated with cognitive impairment, and both are associated with adverse clinical outcomes. Current assessments of sarcopenia are not routinely performed in memory clinics. Temporalis muscle thickness (TMT), which can be measured on routine memory clinic brain magnetic resonance imaging (MRI), has been proposed as a surrogate biomarker of sarcopenia. However, the association of TMT and frailty has not been previously elucidated.</p><h3>Aims</h3><p>To explore the relationship between TMT, measured on coronal T1-weighted brain MRI and frailty, as assessed using a Frailty Index (FI), in a memory clinic cohort.</p><h3>Methods</h3><p>Retrospective cohort study of 140 patients who attended a memory clinic in a tertiary referral hospital in Melbourne, Australia in 2014. TMT and FI of patients with an adequate coronal T1-weighted brain MRI for assessment were collected. Comparisons of TMT between frail (FI ≥ 0.25) and non-frail patients were explored.</p><h3>Results</h3><p>140 patients, median age 75.3 years old (interquartile range [IQR] 67.1–83.2 years old), 55% female. The median TMT was 5.5 mm (IQR 4.4–6.8 mm) and 34% were frail. People who were frail were more likely to be older (<i>p</i> &lt; 0.001), have a lower MMSE (<i>p</i> = 0.003), and reduced TMT thickness (<i>p</i> = 0.011) compared to people who were not frail.</p><h3>Discussion and conclusion</h3><p>Reduced TMT, measured in coronal T1-weighted brain MRI is associated with frailty in this cohort. Future studies incorporating additional measures of sarcopenia (e.g. DXA, dynamometry) to validate the use of TMT in coronal T1-weighted brain MRI are warranted.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03173-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of high body fat and low muscle mass on bone mineral density in postmenopausal women with type 2 diabetes: A DXA-based cross-sectional study","authors":"Yu-Lu Sun,&nbsp;Lei Zhang,&nbsp;Yong-Hong Cao,&nbsp;Wu Dai,&nbsp;Tian-Run Gu","doi":"10.1007/s40520-025-03163-9","DOIUrl":"10.1007/s40520-025-03163-9","url":null,"abstract":"<div><h3>Background and objective</h3><p>Sarcopenic obesity, defined as the coexistence of reduced muscle mass and excess adiposity, may adversely affect bone health, especially in postmenopausal women with type 2 diabetes mellitus (T2DM). This study aimed to explore the association between different body composition phenotypes, particularly sarcopenic obesity, and bone mineral density (BMD) in this population.</p><h3>Methods</h3><p>We retrospectively analyzed 573 postmenopausal women with T2DM hospitalized between September 2020 and October 2024. Based on appendicular skeletal muscle mass index (ASMI) and body fat percentage (BFP) measured by dual-energy X-ray absorptiometry (DXA), participants were classified into control, obesity alone, sarcopenia alone, and sarcopenic obesity groups. Associations between phenotypes and BMD were assessed using Spearman correlation, logistic regression, and restricted cubic spline (RCS) models.</p><h3>Results</h3><p>The obesity group had the highest BMD, while the sarcopenia group had the lowest. Sarcopenic obesity was associated with significantly lower lumbar spine and hip BMD and a higher risk of osteoporosis. Obesity showed a protective effect (OR = 0.515, <i>P</i> = 0.002), whereas sarcopenic obesity increased osteoporosis risk (OR = 3.368, <i>P</i> = 0.007). RCS analysis revealed nonlinear relationships between ASMI, BFP, and BMD.</p><h3>Conclusion</h3><p>Sarcopenic obesity significantly increases osteoporosis risk in postmenopausal women with T2DM, while isolated obesity may protect bone mass. Routine body composition assessment is essential for early identification and targeted intervention.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03163-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does intergenerational support from adult children shape the intrinsic capacity of older adults? Empirical evidence from the CHARLS","authors":"Zhi Zeng,&nbsp;Guiqiong Xie,&nbsp;Yazhi He,&nbsp;Sumei Zhou","doi":"10.1007/s40520-025-03175-5","DOIUrl":"10.1007/s40520-025-03175-5","url":null,"abstract":"<div><h3>Background</h3><p>As China undergoes a rapid demographic shift toward population aging, a critical challenge has emerged for healthy aging policy: how can intergenerational support from adult children be leveraged to maintain and improve the functional ability of older adults? Drawing on nationally representative data, this study investigates the association between such support and the intrinsic capacity of older adults, and explores the pathways through which it operates.</p><h3>Methods</h3><p>This study utilizes data from the 2015, 2018, and 2020 waves of the China health and retirement longitudinal study (CHARLS). A multidimensional index of intergenerational support from adult children is constructed, incorporating financial support, emotional closeness, and caregiving. Two-way fixed effects models are employed to estimate the impact of such support on the intrinsic capacity of older adults. Furthermore, a mediation analysis is conducted—using the bootstrap method—to examine potential pathways through social participation, activities of daily living (ADL), and instrumental activities of daily living (IADL).</p><h3>Results</h3><p>The empirical findings indicate that all three forms of intergenerational support from adult children—financial, emotional, and caregiving—have significant positive effects on the intrinsic capacity of older adults, with caregiving showing the strongest impact. the effects vary across subgroups defined by urban–rural residence, educational attainment, and co-residence status, suggesting substantial heterogeneity. Mediation analysis reveals that social participation partially mediates the effect of financial support (accounting for 14.63% of the total effect), while ADL and IADL explain 60.28% and 53.90% of the effect of caregiving support, respectively.</p><h3>Conclusion</h3><p>intergenerational support from adult children significantly enhances the intrinsic capacity of older adults by promoting social engagement and maintaining functional ability. To advance healthy and active aging, policy efforts should adopt a function-oriented approach that strengthens both family-based support systems and community care infrastructure, while fostering cross-generational resource sharing and coordinated support</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03175-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying latent classes of longitudinal change in picture naming in a population-based sample","authors":"Deborah Finkel,&nbsp;Ying Liu,&nbsp;Margaret Gatz,&nbsp;Stefan Schneider,&nbsp;Raymond Hernandez,&nbsp;Bart Orriens,&nbsp;Arie Kapteyn","doi":"10.1007/s40520-025-03169-3","DOIUrl":"10.1007/s40520-025-03169-3","url":null,"abstract":"<div><p>Although cognitive changes may not become apparent until after age 65, many factors associated with late-life decline are already well-established in midlife. In particular, deficits in picture naming have been associated with early and accelerated cognitive change. A measure of picture vocabulary, requiring participants to name drawings of objects, was collected in 4 waves (each separated by 2 years) of the Understanding America Study, a nationally representative internet panel (mean follow-up = 5.60 years). Participants were 5005 adults ranging in age from 18 to 98 at intake (mean = 48.81); 58% women. Growth mixture models were used to identify latent class structure in age-based quadratic growth models (centered at median age of 53). The best-fitting model identified 3 classes: high intercept and scores increase with age (60% of the sample), medium intercept and scores increase with age (37%), low intercept and no change with age (3%). Analyses of variance indicated that the class for which picture naming did not change with age had a significantly elevated probability of cognitive impairment. Multinomial logistic regression indicated that probability of cognitive impairment contributed to estimation of class membership even in the context of related demographic and cognitive variables. Tasks like Picture Vocabulary may be useful early indicators of onset of cognitive impairment.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03169-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China”","authors":"Efsun Somay","doi":"10.1007/s40520-025-03177-3","DOIUrl":"10.1007/s40520-025-03177-3","url":null,"abstract":"<div><p>I found the study by He et al. quite engaging, as it offers substantial longitudinal evidence linking dental health with various geriatric syndromes in a cohort of 1,094 individuals, specifically sarcopenia, malnutrition risk, frailty, and falls. The authors conducted rigorous clinical evaluations, including assessments of handgrip strength and body composition. They also utilized validated tools, such as the Mini Nutritional Assessment Short-Form (MNA-SF) and the FRAIL scale. The study's findings are significant: individuals with fewer than 10 teeth or those whose tooth loss has affected their daily activities demonstrated markedly increased odds of sarcopenia (OR 1.87–3.25), malnutrition risk (OR 2.31–3.64), and frailty. The absence of proper dentures significantly exacerbated these health risks, highlighting the importance of prosthetic rehabilitation, which, while beneficial, has its limitations in fully restoring oral function. This research strongly advocates for the prioritization of comprehensive oral health assessments and accessible denture provision as essential components of elderly care. The findings are particularly relevant to this rural cohort, emphasizing the need for targeted interventions in geriatric oral health, especially in resource-constrained environments where access to dental care might be limited. To further strengthen the study's relevance and scientific rigor, I propose several constructive recommendations that could enhance the research's overall impact.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03177-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor- The association between sarcopenic obesity and depression in middle-aged and elderly U.S. adults: insights from the NHANES study","authors":"Jiang-yu Tu","doi":"10.1007/s40520-025-03079-4","DOIUrl":"10.1007/s40520-025-03079-4","url":null,"abstract":"<div><p>After reading “The association between sarcopenic obesity and depression in middle-aged and elderly U.S. adults: insights from the NHANES study”, we sincerely appreciate Zhang et al.‘s exploration of the relationship between sarcopenic obesity and depression in middle-aged and elderly populations, which provides new clinical perspectives for preventing sarcopenic obesity and depression. However, to more rigorously and clearly elucidate this relationship, several concerns must be addressed.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03079-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regular glucosamine supplementation and risk of age-related chronic diseases: evidence from a propensity score-matched cohort study","authors":"Jing He,&nbsp;Yue Ma,&nbsp;Yan Jiang,&nbsp;Jianguang Ji,&nbsp;Fengju Song","doi":"10.1007/s40520-025-03171-9","DOIUrl":"10.1007/s40520-025-03171-9","url":null,"abstract":"<div><h3>Background</h3><p>Glucosamine is a widely used dietary supplement, particularly among middle-aged and older adults, with potential health benefits beyond joint health. However, its potential role in the prevention of chronic diseases remains uncertain.</p><h3>Aims</h3><p>To investigate the association between regular glucosamine use and the risk of age-related non-communicable diseases (NCDs) in a large prospective cohort.</p><h3>Methods</h3><p>269,033 participants in the large prospective cohort (UK Biobank) without NCDs at baseline were included. 1:1 propensity-score matching (PSM) was used to match glucosamine users with non-users. Cox proportional hazard regression was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).</p><h3>Results</h3><p>During a median follow-up of 13.8 years, 52,556 participants reported regular glucosamine use. After PSM, 52,525 users and 52,525 non-users were included in the matched cohort. After false discovery rate correction, regular glucosamine use was associated with a significantly lower risk of seven NCDs: esophageal cancer (HR, 0.73; 95% CI, 0.58–0.92), gout (HR, 0.81; 95% CI, 0.72–0.91), chronic obstructive pulmonary disease (HR, 0.86; 95% CI, 0.80–0.93), colorectal cancer (HR, 0.86; 95% CI, 0.78–0.94), chronic liver disease (HR, 0.87; 95% CI, 0.80–0.94), heart failure (HR, 0.88; 95% CI, 0.81–0.96), and coronary heart disease (HR, 0.92; 95% CI, 0.88–0.96).</p><h3>Conclusions</h3><p>Regular use of glucosamine was associated with a reduced risk of several age-related chronic diseases. Further studies are needed to confirm these findings and to clarify its potential role in supporting healthy aging.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03171-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia – the need for an Asian perspective","authors":"Jean Woo","doi":"10.1007/s40520-025-03174-6","DOIUrl":"10.1007/s40520-025-03174-6","url":null,"abstract":"<div><p>Sarcopenia research started in Asia about 25 years ago, and is now a rapidly developing field of research. The Asian Working Group in Sarcopenia was formed in 2014 with the publication of the first Consensus definition, followed and an update in 2019, with a most recent update in 2025. Cut off values used in the definition are different from those in Europe or the US, possibly due to a combination of social determinants of body composition and ethnicity. The importance of detection of sarcopenia in community and hospital settings is recognized; however a gap exists between research, public health and clinical practice in terms of case finding and management.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03174-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}