Aging Clinical and Experimental Research最新文献

{"title":"Loneliness, social isolation, and social support in older adults with cardiovascular diseases: a cross-sectional study in a university-affiliated tertiary hospital in western Iran.","authors":"Fatemeh Darabi, Nafiseh Montazeri, Arash Ziapour, Nammamali Azadi, Fakhreddin Chaboksavar, Shokufe Rezazade","doi":"10.1007/s40520-026-03379-3","DOIUrl":"https://doi.org/10.1007/s40520-026-03379-3","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese.","authors":"Weipeng Wu, Chenfeng Fu, Yu Zhao, Jijun Zhao","doi":"10.1007/s40520-026-03398-0","DOIUrl":"https://doi.org/10.1007/s40520-026-03398-0","url":null,"abstract":"<p><strong>Background: </strong>Dynapenic abdominal obesity contributes to multiple detrimental health consequences, but its association with symptomatic knee osteoarthritis (KOA) remains undefined. This research sought to determine its cross-sectional and longitudinal relationships with the prevalence and incidence of KOA in middle-aged and elderly Chinese.</p><p><strong>Methods: </strong>Cross-sectional analysis comprised 12,872 participants from the 2011 China Health and Retirement Longitudinal Study (CHARLS). The longitudinal analysis utilized a cohort of 11,098 participants without KOA in 2011 as the baseline cohort, with subsequent follow-up conducted until 2018. On the basis of the presence of dynapenia (handgrip strength < 26 kg for men, < 16 kg for women) and abdominal obesity (waist circumference ≥ 90 cm for men, ≥ 85 cm for women), participants were categorized into four distinct groups. To examine cross-sectional and longitudinal associations, we employed Logistic regression models and Cox proportional hazards models, respectively.</p><p><strong>Results: </strong>In the fully adjusted cross-sectional analysis, all three dynapenic abdominal obesity groups exhibited significantly elevated odds of symptomatic KOA compared to the ND/NAO reference group: ND/AO (OR = 1.158, 95% CI: 1.031-1.301), D/NAO (OR = 1.957, 95% CI: 1.590-2.408), and D/AO (OR = 1.438, 95% CI: 1.068-1.934). In the longitudinal cohort (n = 11,098), 2,305 new cases of KOA (21.3%) were found during follow-up. In the same way, all three groups were linked to a higher rate of symptomatic KOA: ND/AO (HR = 1.155, 95% CI: 1.059-1.260), D/NAO (HR = 1.434, 95% CI: 1.167-1.761), and D/AO (HR = 1.369, 95% CI: 1.050-1.785).</p><p><strong>Conclusion: </strong>Our findings indicated that dynapenic abdominal obesity emerges as a potentially important risk indicator for symptomatic KOA in the Chinese middle-aged and elderly cohort.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty in middle adulthood and associations with negative health-related outcomes in NHANES.","authors":"Panaiotis Finamore, Claudio Pedone, Magnus Ekström, David M Mannino, Raffaele Antonelli Incalzi, Simone Scarlata","doi":"10.1007/s40520-026-03400-9","DOIUrl":"https://doi.org/10.1007/s40520-026-03400-9","url":null,"abstract":"<p><strong>Background: </strong>Frailty represents a state of compromised ability to cope with environmental stressors and is associated with negative health-related outcomes in older adults. The study objective is to investigate the prevalence and whether frailty associates with negative health-related outcomes in middle-aged adults.</p><p><strong>Methods: </strong>Data were sourced from three 2-year cycles of NHANES surveys and combined with Public-use Linked Mortality Files. A frailty index incorporating thirty variables was developed according to recommended criteria. \"Prefrail\" individuals were defined with a frailty index value ranging from 0.08 to 0.25, while \"Frail\" ≥0.25. A 10-year survival analysis was conducted using the Kaplan-Meier estimator, stratified by frailty state, and hazard ratios were calculated. Associations between frailty and outcomes were quantified using logistic regression models. Bootstrapped C-index and Brier score were calculated in the overall sample and stratified by decades of age.</p><p><strong>Results: </strong>In a sample of 5,745 middle-aged adults, 11% were identified as frail. Over a median follow-up of 5.9 years, 3% of participants died. The frailty index increased with age and its determinants differed across decades of age. Frail, middle aged, individuals faced a three-to-fourfold higher mortality risk, with a C-index of around 65%. Additionally, frailty was associated with a higher likelihood of hospitalization, increased health-care utilization, and changes in health status. Multimorbidity represented a confounder of frailty in the fourth decade, but not in the fifth.</p><p><strong>Conclusion: </strong>Frailty associates with negative health-related outcomes in middle-aged adults, emphasizing the importance of a comprehensive assessment. Multimorbidity only partially accounts for this association.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current use and practices of lung ultrasound in geriatric care: insights from a national survey.","authors":"Alberto Finazzi, Tessa Mazzarone, Emma Esposito, Michele Cerasuolo, Martina Salvati, Lavinia Vitali, Daniela Guarino, Nicoletta Cerundolo, Monica Torrini, Antonio Nouvenne, Fulvio Lauretani, Andrea Ungar, Giuseppe Bellelli, Raffaele Antonelli Incalzi, Dario Leosco, Andrea Ticinesi, Simone Scarlata, Chukwuma Okoye","doi":"10.1007/s40520-026-03399-z","DOIUrl":"https://doi.org/10.1007/s40520-026-03399-z","url":null,"abstract":"<p><strong>Background: </strong>Lung ultrasound (LUS) has gained increasing relevance in the evaluation of respiratory symptoms due to its bedside applicability, diagnostic accuracy, and safety. However, its adoption in geriatric care remains limited.</p><p><strong>Aims: </strong>This study aimed to assess current LUS availability, use, and technical practices among Italian geriatricians.</p><p><strong>Methods: </strong>A nationwide, cross-sectional survey was conducted among members of the Italian Society of Gerontology and Geriatrics. The 44-item questionnaire explored LUS availability, use, indications, and technical practices in acute care. LUS proficiency was operationally defined as the ability to perform the scan, interpret findings and integrate them with clinical data independently or under supervision.</p><p><strong>Results: </strong>Responders (n = 154), representing 57 hospitals in 17 Italian regions, reported wide interest in LUS and recognized its utility for improving the care of older patients with acute respiratory failure. The main indications, which LUS was used for in their clinical experience, were assessment of volume status, pleural effusions and heart failure. Although availability of LUS equipment in the clinical units of responders was generally high (94%), 27.3% of them were non-proficient in LUS and more than 85% reported that a trained operator was not available 24/7. Heterogeneity also emerged in examination techniques and reporting among LUS-proficient responders, with only 6% adopting validated scanning protocols and 13% using standardized reporting formats.</p><p><strong>Conclusion: </strong>This survey reveals limited integration of LUS in geriatric care with heterogeneous practices. Structured training pathways and geriatric-specific standardized LUS protocols are urgently needed to enable broader, safer, and more consistent implementation in acute geriatric care.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in major postoperative morbidity after elective abdominal surgery: independent of chronological age, frailty, and muscle strength in adjusted analysis.","authors":"Eugenia Semeraro, Silvia Malerba, Sergii Girnyi, Elena Montanari, Alessandra Marano, Mauro Santarelli, Jaroslaw Skokowski, Ruslan Duka, Robert Molchanov, Yogesh Vashist, Karol Polom, Virginia Boccardi, Luigi Marano","doi":"10.1007/s40520-026-03387-3","DOIUrl":"https://doi.org/10.1007/s40520-026-03387-3","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological impact of age and comorbidities: findings from the REALISM and SENIOR-HLA-DR cohorts.","authors":"Léa Vieilledent, Sylvain Gaujard, Morgane Gossez, Anne Broyer, Maxime Bodinier, Samuel Le Goff, Karine Di-Valentin, Elisa Renaud, Constance Dumay, Anne-Perrine Foray, Guillaume Monneret, Fabienne Venet","doi":"10.1007/s40520-026-03389-1","DOIUrl":"https://doi.org/10.1007/s40520-026-03389-1","url":null,"abstract":"<p><strong>Background: </strong>The ageing population faces numerous physiological changes, among which immunosenescence plays a central role. Understanding the mechanisms underlying immunosenescence remains a priority. Within this framework, the contribution of comorbidities to immune dysfunction is still poorly characterized, despite growing evidence suggesting that it may represent a critical determinant in the evaluation of immunosenescence. The main objective of this report was to disentangle the respective impacts of age and comorbidities. To this end, we focused on immunological parameters originally developed in the context of sepsis, a condition that shares many immunological defects with immunosenescence.</p><p><strong>Methods: </strong>Data were obtained from two cohorts: the REALISM cohort, including healthy elderly individuals, and the SENIOR-HLA-DR cohort, consisting of a real-life hospitalized geriatric population. Immunological parameters assessed were circulating IL-6, percentage of immature neutrophils, monocyte HLA-DR expression (mHLA-DR), neutrophil-to-lymphocyte ratio (NLR), T lymphocyte count, and interferon-γ release assay (IGRA) in response to phytohemagglutinin (PHA).</p><p><strong>Results: </strong>In the absence of comorbidities, age had no detectable effect on immune parameters in the REALISM cohort (n = 174 individuals). The SENIOR-HLA-DR cohort (n = 76 patients) revealed that cardiovascular comorbidities exerted the greatest influence, being associated with significantly reduced mHLA-DR expression and increased NLR. Infections further triggered substantial alterations in inflammation and innate immunity, characterized by elevated percentages of immature neutrophils and decreased mHLA-DR expression.</p><p><strong>Discussion-conclusions: </strong>Our findings indicate a limited impact of chronological age and comorbidities on the selected immunological parameters. These results suggest that routine clinical tools may be insufficient to fully capture the complexity of immunosenescence.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging without biology: limitations of CT-derived psoas muscle volume as a standalone diagnostic criterion for sarcopenia","authors":"Harsh Jain,&nbsp;Samarth Mittal,&nbsp;Buddhadev Chowdhury","doi":"10.1007/s40520-026-03395-3","DOIUrl":"10.1007/s40520-026-03395-3","url":null,"abstract":"<div>\u0000 \u0000 <p>We comment on the study by Choi et al., which proposes CT-derived psoas muscle volume (PV) as a diagnostic indicator for sarcopenia. The study is well designed, using automated deep-learning-based CT segmentation for psoas muscle volume measurement, and adds to the growing interest in opportunistic CT-based muscle assessment. However, a few points may warrant consideration before wider clinical application. These include differences from current consensus definitions of sarcopenia, limitations related to the use of BIA as a reference standard, and the lack of validation against clinical outcomes. Furthermore, volumetric measures alone may not fully capture the histopathological changes associated with sarcopenia, including muscle fibre atrophy, fat infiltration, and neuromuscular denervation. We also note that applying T-score thresholds from osteoporosis to muscle volume is not straightforward, as no comparable outcome data currently exist to anchor these cut-offs in sarcopenia.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sempreverdità (evergreen vitality): a resilience-based, trajectory-oriented extension of healthy ageing","authors":"Davide Maria Andreucci,&nbsp;Virginia Boccardi","doi":"10.1007/s40520-026-03397-1","DOIUrl":"10.1007/s40520-026-03397-1","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between weight-adjusted waist and incidence of low back pain: evidence from the China Health and Retirement Longitudinal Study.","authors":"Xueru Shen, Dexin Hu, Yixing Lu, Lixin Zhao, Hua Yuan, Xiaolong Sun","doi":"10.1007/s40520-026-03351-1","DOIUrl":"https://doi.org/10.1007/s40520-026-03351-1","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationships between malnutrition, dehydration, frailty, and sarcopenia in older adults with proximal femur fractures: a prospective observational study.","authors":"Belinda Trobec, Gianluca Canton, Emma Spedicato, Eleonora Wabitsch, Paolo De Colle, Michela Zanetti, Andrea Marchetti, Luigi Murena, Chiara Ratti","doi":"10.1007/s40520-026-03364-w","DOIUrl":"https://doi.org/10.1007/s40520-026-03364-w","url":null,"abstract":"<p><strong>Background: </strong>Proximal femur fractures (PFFs) are a hallmark of frailty in patients aged ≥ 65 years. Geriatric frailty is multifactorial, with malnutrition, dehydration, and sarcopenia negatively impacting outcomes after PFF.</p><p><strong>Aims: </strong>The primary aim of this study was to examine the interrelationships between frailty, malnutrition, hydration status, and ultrasound-defined muscle impairment in older patients with proximal femur fracture. As a secondary objective, we explored the association of these vulnerability domains with 3-month mortality as an exploratory outcome.</p><p><strong>Methods: </strong>In this prospective observational study, 108 consecutive patients aged ≥ 65 years undergoing surgical treatment for PFF at Cattinara Hospital (Trieste) were evaluated. Clinical, nutritional (MNA, MUST), functional (ADL, CFS, NHFS, MPI), cognitive (SPMSQ), and dehydration (CDS) assessments were performed. Ultrasound sarcopenia index (USI) measurements were obtained in both upper and lower limbs of 78 patients.</p><p><strong>Results: </strong>Mean age was 85.9 ± 6.6 years. Malnutrition, clinical dehydration, and frailty were present in 2.7%, 38%, and 56% of patients, respectively. Among patients assessed by ultrasound, 39% showed sarcopenic features. Nutritional status was significantly associated with frailty, dehydration, ultrasound-defined sarcopenia, and calf circumference (p < 0.05). At univariate analysis, poorer nutritional, cognitive, and functional status, frailty, and preoperative complications were associated with higher 3-month mortality, whereas surgery within 72 h was protective.</p><p><strong>Discussion: </strong>Malnutrition, dehydration, and sarcopenia frequently coexist and are closely correlated with geriatric frailty and mortality in patients aged ≥ 65 years with PFF.</p><p><strong>Conclusions: </strong>These findings support the relevance of a comprehensive orthogeriatric assessment to better characterize biological vulnerability and guide perioperative care.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}