{"title":"眼动参数作为帕金森病患者左旋多巴反应性和诊断的生物标志物","authors":"Qibing Luo, Ziqi Gao, Qi Qi, Siming Rong, Rui Yang, Chentao He, Mengfei Cai, Piao Zhang, Yuhu Zhang","doi":"10.1007/s40520-025-03089-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Abnormalities in characteristic eye movements have been identified in Parkinson's disease (PD) patients.</p><p><strong>Aim: </strong>To determine if eye movement parameters can serve as biomarkers for diagnosing PD and predicting therapeutic responses to levodopa.</p><p><strong>Methods: </strong>We enrolled 128 PD patients and 28 healthy controls, assessing eye movements before and after levodopa administration.</p><p><strong>Results: </strong>Specific eye movement parameters robustly differentiated PD patients from controls, with an AUC of 0.856, and maintained robustness post-levodopa. Correlations were found between changes in eye movement parameters and motor symptom improvements, leading to a predictive model for levodopa responsiveness with an AUC of 0.783.</p><p><strong>Discussion and conclusions: </strong>Eye movement assessments offer an objective tool for PD diagnosis and levodopa responsiveness prediction.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"182"},"PeriodicalIF":3.4000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144069/pdf/","citationCount":"0","resultStr":"{\"title\":\"Eye movement parameters as biomarkers for diagnosis and levodopa responsiveness in patients with Parkinson's disease.\",\"authors\":\"Qibing Luo, Ziqi Gao, Qi Qi, Siming Rong, Rui Yang, Chentao He, Mengfei Cai, Piao Zhang, Yuhu Zhang\",\"doi\":\"10.1007/s40520-025-03089-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Abnormalities in characteristic eye movements have been identified in Parkinson's disease (PD) patients.</p><p><strong>Aim: </strong>To determine if eye movement parameters can serve as biomarkers for diagnosing PD and predicting therapeutic responses to levodopa.</p><p><strong>Methods: </strong>We enrolled 128 PD patients and 28 healthy controls, assessing eye movements before and after levodopa administration.</p><p><strong>Results: </strong>Specific eye movement parameters robustly differentiated PD patients from controls, with an AUC of 0.856, and maintained robustness post-levodopa. Correlations were found between changes in eye movement parameters and motor symptom improvements, leading to a predictive model for levodopa responsiveness with an AUC of 0.783.</p><p><strong>Discussion and conclusions: </strong>Eye movement assessments offer an objective tool for PD diagnosis and levodopa responsiveness prediction.</p>\",\"PeriodicalId\":7720,\"journal\":{\"name\":\"Aging Clinical and Experimental Research\",\"volume\":\"37 1\",\"pages\":\"182\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144069/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging Clinical and Experimental Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40520-025-03089-2\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Clinical and Experimental Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40520-025-03089-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Eye movement parameters as biomarkers for diagnosis and levodopa responsiveness in patients with Parkinson's disease.
Background: Abnormalities in characteristic eye movements have been identified in Parkinson's disease (PD) patients.
Aim: To determine if eye movement parameters can serve as biomarkers for diagnosing PD and predicting therapeutic responses to levodopa.
Methods: We enrolled 128 PD patients and 28 healthy controls, assessing eye movements before and after levodopa administration.
Results: Specific eye movement parameters robustly differentiated PD patients from controls, with an AUC of 0.856, and maintained robustness post-levodopa. Correlations were found between changes in eye movement parameters and motor symptom improvements, leading to a predictive model for levodopa responsiveness with an AUC of 0.783.
Discussion and conclusions: Eye movement assessments offer an objective tool for PD diagnosis and levodopa responsiveness prediction.
期刊介绍：
Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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