Eye movement parameters as biomarkers for diagnosis and levodopa responsiveness in patients with Parkinson's disease.

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-06-06 DOI:10.1007/s40520-025-03089-2

Qibing Luo, Ziqi Gao, Qi Qi, Siming Rong, Rui Yang, Chentao He, Mengfei Cai, Piao Zhang, Yuhu Zhang

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引用次数: 0

Abstract

Background: Abnormalities in characteristic eye movements have been identified in Parkinson's disease (PD) patients.

Aim: To determine if eye movement parameters can serve as biomarkers for diagnosing PD and predicting therapeutic responses to levodopa.

Methods: We enrolled 128 PD patients and 28 healthy controls, assessing eye movements before and after levodopa administration.

Results: Specific eye movement parameters robustly differentiated PD patients from controls, with an AUC of 0.856, and maintained robustness post-levodopa. Correlations were found between changes in eye movement parameters and motor symptom improvements, leading to a predictive model for levodopa responsiveness with an AUC of 0.783.

Discussion and conclusions: Eye movement assessments offer an objective tool for PD diagnosis and levodopa responsiveness prediction.

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眼动参数作为帕金森病患者左旋多巴反应性和诊断的生物标志物

背景：帕金森病（PD）患者的特征性眼球运动异常已被确定。目的：确定眼动参数是否可以作为帕金森病诊断和左旋多巴治疗反应预测的生物标志物。方法：我们招募了128名PD患者和28名健康对照者，评估左旋多巴给药前后的眼动。结果：特定眼动参数能将PD患者与对照组区分开来，AUC为0.856，且在左旋多巴后仍能保持稳健性。眼动参数的变化与运动症状的改善之间存在相关性，因此建立了左旋多巴反应性的预测模型，AUC为0.783。讨论与结论：眼动评估为PD诊断和左旋多巴反应性预测提供了客观的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.