Aging Clinical and Experimental Research最新文献

{"title":"Association between the coexistence of chronic kidney disease and sarcopenia with cardiovascular disease and mortality","authors":"Lijun Jiang,&nbsp;Liangliang Xu,&nbsp;Wen Sun,&nbsp;Keyu Bian,&nbsp;Yuan Wang","doi":"10.1007/s40520-025-03003-w","DOIUrl":"10.1007/s40520-025-03003-w","url":null,"abstract":"<div><h3>Background</h3><p>Chronic kidney disease (CKD) and sarcopenia are independently associated with adverse cardiovascular and mortality outcomes. However, the combined impact of CKD and sarcopenia remains poorly understood. To evaluate the combined effects of CKD and sarcopenia on cardiovascular disease (CVD) and mortality risks in a large population-based cohort.</p><h3>Methods</h3><p>We analyzed data from 477,380 participants in the UK Biobank, categorized into four groups based on the presence or absence of CKD and sarcopenia: Non-CKD Non-Sarcopenia, Non-CKD Sarcopenia, CKD Non-Sarcopenia, and CKD Sarcopenia. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD and mortality outcomes. Kaplan-Meier survival analyses compared event-free survival across the groups.</p><h3>Results</h3><p>Participants with both CKD and sarcopenia exhibited the highest risks across all outcomes compared to those without either condition. For stroke, the adjusted HR was 2.17 (95% CI: 1.65–2.86), significantly higher than CKD alone (HR: 1.69, 95% CI: 1.47–1.94) or sarcopenia alone (HR: 1.28, 95% CI: 1.03–1.59). Similar trends were observed for coronary artery disease (CAD) and heart failure (HF), with HRs of 1.53 (95% CI: 1.38–1.69) and 2.22 (95% CI: 1.99–2.47), respectively, in the CKD-sarcopenia group. The coexistence of CKD and sarcopenia was also associated with significantly elevated all-cause mortality (HR: 2.59, 95% CI: 2.17–3.09) and cardiovascular-specific mortality (HR: 4.08, 95% CI: 2.95–5.66).</p><h3>Conclusion</h3><p>The coexistence of CKD and sarcopenia significantly amplifies the risks of CVD and mortality, highlighting the need for integrated management strategies to address this high-risk population. Early detection and tailored interventions targeting these dual risk factors may mitigate their compounded burden and improve clinical outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03003-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of alternative healthy eating index with risk of frailty among metabolic syndrome individuals: a cross-sectional study","authors":"Yi Wei,&nbsp;Min Zha,&nbsp;Jiangyi Yu","doi":"10.1007/s40520-025-02992-y","DOIUrl":"10.1007/s40520-025-02992-y","url":null,"abstract":"<div><h3>Background</h3><p>Mounting evidence identifies diet quality as a frailty modifying factor. Individuals suffering from metabolic syndrome (MetS) are more likely to be affected by frailty. Therefore, our research sought to explore the relationship of Alternative Healthy Eating Index (AHEI) with frailty risk among patients with MetS.</p><h3>Methods</h3><p>National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018 were gathered. Frailty Index (FI) was utilized for assessment of frailty status. Weighted multivariate logistic regression model was adopted for investigating the association of AHEI with frailty among patients with MetS. Subgroup analysis, interaction test and restricted cubic spline (RCS) test were also performed in this study.</p><h3>Results</h3><p>When the covariates considered were entirely adjusted for, higher AHEI scores exhibited significant association with reduced frailty risk (OR = 0.99,95%CI = 0.981–0.998, <i>P</i> = 0.022). Relative to the frailty risk among participants belonging to the lowest AHEI quartile(Q1), that of individuals in the highest AHEI quartile(Q4) decreased by 32% (OR = 0.68, 95% CI = 0.51–0.92, <i>P</i> = 0.01). Additionally, the negative association of AHEI with frailty persisted for all subgroup analyses, which also indicates the reliability of the relationship.</p><h3>Conclusion</h3><p>For patients with MetS, higher AHEI scores reduce the risk of developing frailty. This investigation provides valuable knowledge that could be utilized for treating MetS patients clinically and guiding healthy eating program development.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02992-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function in generally healthy adults age 70 years and older in the 5-country DO-HEALTH study: MMSE and MoCA scores by sex, education and country","authors":"Melanie Kistler-Fischbacher,&nbsp;Ghazala Gohar,&nbsp;Caroline de Godoi Rezende Costa Molino,&nbsp;Katharina Geiling,&nbsp;Tatjana Meyer-Heim,&nbsp;Reto W. Kressig,&nbsp;E. John Orav,&nbsp;Bruno Vellas,&nbsp;Sophie Guyonnet,&nbsp;José A.P. da Sliva,&nbsp;René Rizzoli,&nbsp;Gabriele Armbrecht,&nbsp;Elisabeth Steinhagen-Thiessen,&nbsp;Andreas Egli,&nbsp;Heike A. Bischoff-Ferrari","doi":"10.1007/s40520-025-02946-4","DOIUrl":"10.1007/s40520-025-02946-4","url":null,"abstract":"<div><h3>Background</h3><p>Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are validated and frequently used screening tools for cognitive function.</p><h3>Aims</h3><p>To present MMSE and MoCA scores by sex, age and education among community-dwelling older adults.</p><h3>Methods</h3><p>This is a post-hoc observational analysis using data from the DO-HEALTH trial, which included generally healthy adults (≥ 70 years) from Switzerland, Germany, Austria, France, and Portugal who scored at least 24 points on the MMSE at baseline. We present MMSE and MoCA scores overall and by country, sex, age (70–74 years, ≥ 75 years), education (≤ and &gt; median education years).</p><h3>Results</h3><p>2151 DO-HEALTH participants (mean age 74.9 years, 57% aged 70–74 years, 62% women) were included. The median (IQR) years of education was 12 (10–15), median MMSE score was 29 (28–30) and median MoCA score was 26 (23–28) points. In subgroups by sex, age, and education, the median MMSE score remained 29 for all subgroups, except for participants with shorter education (≤ 12 years) and higher age (≥ 75), who scored 28 points. For MoCA, the median score in subgroups ranged from 24 to 27 points. Participants with shorter education (≤ 12 years) and higher age (≥ 75) had lowest scores (men 24, women 25 points).</p><h3>Conclusions</h3><p>We provide MMSE and MoCA scores for generally healthy, community-dwelling older adults from Switzerland, Germany, Austria, France and Portugal. The median MMSE and MoCA scores differed with age and education, and – less consistently – with sex.</p><h3>Trial registration</h3><p>International Trials Registry (clinicaltrials.gov; registration ID: NCT01745263), registered December 2012.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02946-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fruit and vegetable consumption and injurious falls among adults aged ≥ 50 years from low- and middle-income countries","authors":"Lee Smith,&nbsp;Guillermo F. López Sánchez,&nbsp;Nicola Veronese,&nbsp;Mark A Tully,&nbsp;Damiano Pizzol,&nbsp;Laurie Butler,&nbsp;Masoud Rahmati,&nbsp;José Francisco López-Gil,&nbsp;Yvonne Barnett,&nbsp;Louis Jacob,&nbsp;Pinar Soysal,&nbsp;Alberto Castagna,&nbsp;Jae Il Shin,&nbsp;Ai Koyanagi","doi":"10.1007/s40520-025-02966-0","DOIUrl":"10.1007/s40520-025-02966-0","url":null,"abstract":"<div><h3>Objective</h3><p>Inadequate fruit and vegetable consumption may increase risk for falls. However, to date, only one study has examined this association in a sample restricted to females, while the mediators of this association are largely unknown. Therefore, we aimed to examine the association between fruit and vegetable consumption and injurious falls, and to identify potential mediators in a sample including both males and females.</p><h3>Methods</h3><p>Cross-sectional, nationally representative data from the World Health Organization (WHO) Study on global AGEing and adult health (SAGE) were analyzed. Fruit/vegetable consumption was divided into two groups: ≥2 servings of fruits and ≥3 servings of vegetables per day (adequate consumption) or else (inadequate consumption). Fall-related injury referred to those that occurred in the past 12 months. Multivariable logistic regression and mediation analysis were conducted.</p><h3>Results</h3><p>Data on 34,129 individuals aged ≥ 50 years were analyzed (mean age 62.4 years; 52.1% females). Overall, inadequate fruit/vegetable intake was associated with a significant 1.41 (95%CI = 1.05–1.90) times higher odds for injurious falls. This association was only significant among females (OR = 1.96; 95%CI = 1.32–2.85). Mediation analysis showed that affect (mediated percentage 8.8%), cognition (7.2%), and sleep/energy (7.5%) were significant mediators, but vision, grip strength, and gait speed were not.</p><h3>Conclusions</h3><p>Inadequate fruit and vegetable consumption was associated with higher odds for injurious falls among adults aged ≥ 50 years (especially females), and this association was partly mediated by cognition, affect, and sleep/energy. Future longitudinal studies are necessary to provide more insight into the underlying mechanisms, and to assess whether increasing fruit/vegetable consumption may reduce risk for falls.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02966-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia and geriatric syndromes in older patients admitted to an intermediate care unit: prospective observational study","authors":"Francesca Dini,&nbsp;Stefania Mancini,&nbsp;Alessia Girelli,&nbsp;Daniela Perelli Ercolini,&nbsp;Alessandro Reggiani,&nbsp;Yanely Sarduy Alonso,&nbsp;Marco Inzitari,&nbsp;Giuseppe Bellelli,&nbsp;Alessandra Marengoni,&nbsp;Simona Gentile,&nbsp;Alessandro Morandi","doi":"10.1007/s40520-025-02950-8","DOIUrl":"10.1007/s40520-025-02950-8","url":null,"abstract":"<div><h3>Background</h3><p>Dysphagia is a geriatric syndrome often unrecognized or underestimated, and there is a lack of studies in a heterogeneous population in intermediate care (IC) services. This study aims to describe the prevalence of dysphagia and its association with geriatric syndromes in older patients in IC.</p><h3>Methods</h3><p>Prospective cohort study of patients 70 years and older admitted to an IC unit. At admission, the severity of the clinical conditions, comorbidity, delirium, frailty, sarcopenia, nutritional status, and medications were assessed. Each patient was evaluated with the 3-OZ test, and dysphagia was confirmed by a speech therapy consultation. Two multivariable logistic regression models were used to evaluate the association of dysphagia at admission with geriatric syndromes (model 1), along with the severity of illness and admission diagnosis (model 2).</p><h3>Results</h3><p>A total of 455 patients were included. The prevalence of dysphagia was 10% and there was a high prevalence of mild-moderate dysphagia in patients with cognitive impairment and moderate risk of malnutrition. In the univariate analysis, an association was found between dysphagia and sarcopenia, malnutrition, and use of antipsychotics. In Model 1, higher odds of dysphagia were associated with the severity of comorbidity (Odds Ratio 6.49, 95% Confidence Interval: 2.02–20.78), and cognitive impairment (OR 0.91, 95% CI: 0.88–10.62); in Model 2, the severity of clinical conditions-NEWS2 (OR 1.61, 95% CI: 1.23–2.13) was associated with dysphagia, besides the severity of comorbidity and cognitive impairment. In a subset of 300 patients, delirium was also associated with dysphagia.</p><h3>Conclusions</h3><p>The study provides novel information on dysphagia prevalence in patients admitted to an IC unit and its association with geriatric syndromes. Additional research is needed to further define the relationship between geriatric syndromes and dysphagia, and to adequately standardize speech therapist treatments.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02950-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystatin-c / total cholesterol ratio as a predictor of probable sarcopenia in geriatric population from 12 European countries","authors":"Rizwan Qaisar,&nbsp;M. Azhar Hussain,&nbsp;Asima Karim,&nbsp;Firdos Ahmad,&nbsp;Atif Awad,&nbsp;Mohammed Alsaeed,&nbsp;Shaea A. Alkahtani","doi":"10.1007/s40520-025-03007-6","DOIUrl":"10.1007/s40520-025-03007-6","url":null,"abstract":"<div><h3>Background</h3><p>A low handgrip strength (HGS) is associated with several diseases in older adults. However, predictive biomarkers of future low HGS are poorly known. We investigated the prognostic efficacy of the ratio of plasma cystatin-c and total cholesterol (CT ratio) levels for predicting future low HGS in Europe.</p><h3>Methods</h3><p>The data was collected from the Survey of Health, Ageing, and Retirement in Europe (SHARE) between 2015 and 2021-22. The study participants were geriatric adults aged 50 or above (<i>n</i> = 17,698) from 12 European countries. The baseline data in 2015 included the measurements of CT ratio from participants with normal HGS. The participants who developed low HGS in subsequent years were included. We also investigated the quality of life, difficulties performing daily activities, and several comorbidities in the study population.</p><h3>Results</h3><p>In a multivariate-adjusted model, male gender, advancing age, poor quality of life, difficulties performing daily activities, and the presence of depression, high blood pressure, diabetes mellitus, Alzheimer’s disease, and osteoarthritis were associated with a higher risk of developing low HGS. CT ratio exhibited significant prognostic accuracy for low HGS among men and women aged 60–79, irrespective of the quality of life, degree of depression, difficulties performing daily activities, and the presence of comorbidities, including depression, high blood pressure, diabetes mellitus, Alzheimer’s disease, and osteoarthritis.</p><h3>Conclusion</h3><p>Collectively, the CT ratio exhibits adequate prognostic accuracy for low HGS, which is not significantly affected by comorbidities and functional limitations. Our findings have clinical and policy implications in timely identifying older adults at risk of developing low HGS.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03007-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive reserve can impact trajectories in ageing: a longitudinal study","authors":"Sonia Montemurro,&nbsp;Raffaella Ida Rumiati,&nbsp;Veronica Pucci,&nbsp;Massimo Nucci,&nbsp;Sara Mondini","doi":"10.1007/s40520-025-03000-z","DOIUrl":"10.1007/s40520-025-03000-z","url":null,"abstract":"<div><p>Trajectories of decline from healthy aging to dementia are not linear; they may range from a more attenuated to a more accelerated cognitive worsening. This longitudinal study investigates the impact of Cognitive Reserve (CR) on task performance in a cohort of 117 individuals (mean age 74.89; SD = 7.43) who experienced difficulties in everyday life and referred to a neuropsychology unit for cognitive assessment. Only participants assessed three times were included in the study. CR was estimated for each participant based on educational level and occupational complexity. Results revealed a general decline in global cognitive performance over time, in particular from the second to the final assessment (mean years = 2.95 ± 2.11). The two groups (high CR vs. low CR) did not differ for sex or age across assessments. Individuals with high CR not only exhibited greater cognitive efficiency at baseline—consistent with Stern’s (2009) construct—but also maintained a more stable cognitive state over time compared to those with low CR. Post-hoc analyses confirmed that while the two groups did not differ in task performance between the first and the second assessment, they significantly differed from the second to the third. Individuals with high CR (even those who were diagnosed with a major neurocognitive disorder) preserved their cognitive profile whereas the profile of those with low CR declined significantly. This study demonstrates that cognitive trajectories are shaped by CR and that, despite the plausible progression of brain deterioration, individuals with high CR may not experience an accelerated cognitive deterioration. Instead, they may exhibit a more gradual decline and sustain cognitive functioning for a longer period despite age-related changes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03000-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between gut microbiota and accelerated aging and frailty: a Mendelian randomization study","authors":"Zhiliang Yan,&nbsp;Guoyu Guan,&nbsp;Hanqi Jia,&nbsp;Hanyu Li,&nbsp;Sangdan Zhuoga,&nbsp;Songbai Zheng","doi":"10.1007/s40520-025-02971-3","DOIUrl":"10.1007/s40520-025-02971-3","url":null,"abstract":"<div><h3>Background</h3><p>The recent observational studies have unveiled the correlation between the composition and dynamic alterations of the gut microbiome and aging; however, the causal relationship remains uncertain.</p><h3>Aims</h3><p>The objective of this study is to investigate the causal relationship between the gut microbiome and accelerated aging as well as frailty, from a genetic perspective.</p><h3>Methods</h3><p>We obtained data on the gut microbiome, intrinsic epigenetic age acceleration, and Frailty Index from published large-scale genome-wide association studies. A two-sample Mendelian randomization analysis was conducted primarily using inverse variance weighting model. We utilized the MR-Egger intercept analysis, IVW method, the Cochran Q test, and the leave-one-out analysis to assess the robustness of the results.</p><h3>Results</h3><p>IVW analysis indicated a potential association between Peptococcus (OR: 1.231, 95% CI 1.013–1.497, <i>P</i> = 0.037), Dialister (OR: 1.447, 95% CI 1.078–1.941, <i>P</i> = 0.014) and Subdoligranulum (OR: 1.538, 95% CI 1.047–2.257, <i>P</i> = 0.028) with intrinsic epigenetic age acceleration; while Prevotella 7 (OR: 0.792, 95% CI 0.672–0.935, <i>P</i> = 0.006) was associated with a potential protective effect. Allisonella (OR: 1.033, 95% CI 1.005–1.063, <i>P</i> = 0.022), Howardella (OR: 1.026, 95% CI 1.002–1.050, <i>P</i> = 0.031) and Eubacterium coprostanoligenes (OR: 1.037, 95% CI 1.001–1.073, <i>P</i> = 0.042) were associated with an increased risk of frailty; conversely, Flavonifractor (OR: 0.954, 95% CI 0.920–0.990, <i>P</i> = 0.012) and Victivallis (OR: 0.984, 95% CI 0.968-1.000, <i>P</i> = 0.049) appeared to exhibit a potential protective effect against frailty.</p><h3>Conclusion</h3><p>The findings of this study provide further evidence for the genetic correlation between gut microbiota and accelerated aging as well as frailty, enhancing the understanding of the role of gut microbiota in aging-related processes. However, the underlying mechanisms and potential clinical applications require further investigation before any targeted interventions can be developed.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02971-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters, metabolic factors, and quality of life in diabetic sarcopenia: a randomized controlled clinical trial","authors":"Ramin Abdi Dezfouli,&nbsp;Narges Zargar Balajam,&nbsp;Ramin Heshmat,&nbsp;Gita Shafiee","doi":"10.1007/s40520-025-02969-x","DOIUrl":"10.1007/s40520-025-02969-x","url":null,"abstract":"<div><h3>Aim</h3><p>To investigate the efficacy of Sarcomeal® sachet, as a protein supplement, plus vitamin D3 on muscle parameters, metabolic factors, and quality of life (QoL) in individuals with diabetes and sarcopenia.</p><h3>Methods</h3><p>Sixty individuals were randomized into the control or intervention group. The intervention group received a daily dose of one Sarcomeal sachet and 1000 IU of vitamin D and both groups were recommended to consume protein-rich food, be educated about the disease, and perform physical activity for 12 weeks. Various assessments including muscle parameters, blood tests, and QoL were conducted at the beginning and the end of the trial.</p><h3>Results</h3><p>Over 12 weeks, although the intervention group had significant improvements in mean skeletal muscle mass index (SMI) (change: 0.17[0.016, 0.329] kg/m²; <i>p</i> &lt; 0.05) and handgrip strength (change: 1.33[0.256, 2.410] kg; <i>p</i> &lt; 0.05), differences between groups were not statistically significant. However, significant improvements were observed in lean mass (1.70 [0.749, 2.665] kg; <i>P</i> &lt; 0.01) and lean mass index (0.62[0.287, 0.954] kg/m²; <i>P</i> &lt; 0.01) between groups. Weight was maintained in the intervention arm, whereas the control arm experienced significant weight loss (1.87 [0.654, 3.109] kg; <i>P</i> &lt; 0.01). Participants in the intervention arm did not show significant changes in blood parameters. The most reported side effects were loss of appetite (50%) and stomach heaviness (20.8%).</p><h3>Conclusion</h3><p>This mixture of supplements significantly improved lean muscle mass, preserved physical function, and helped maintain weight, supporting its potential as a strategy to counter muscle loss and enhance the QoL in diabetic sarcopenia patients.</p><h3>Clinical trial registration</h3><p>This trial is registered at the Iranian Registry of Clinical Trials (IRCT) with IRCT20230831059311N1 ID.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02969-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention","authors":"Fiona Ecarnot,&nbsp;Jotheeswaran Amuthavalli Thiyagarajan,&nbsp;Mario Barbagallo,&nbsp;Jane Barratt,&nbsp;Tor Biering-Sørensen,&nbsp;Elisabeth Botelho-Nevers,&nbsp;Marco Del Riccio,&nbsp;Marco Goeijenbier,&nbsp;Stefan Gravenstein,&nbsp;Luis Lourenço,&nbsp;Jean-Pierre Michel,&nbsp;Daniela Pedicino,&nbsp;Cornel Sieber,&nbsp;Antoni Torres,&nbsp;Nicola Veronese,&nbsp;Massimo Volpe,&nbsp;Thomas Weinke,&nbsp;Stefania Maggi","doi":"10.1007/s40520-025-02968-y","DOIUrl":"10.1007/s40520-025-02968-y","url":null,"abstract":"<div><p>Cardiovascular and infectious diseases both feature among the leading causes of death among men and women in the world. The pathophysiological pathways of infection and cardiovascular disease intersect, and there is a bidirectional relationship between the two. Vaccines are available for the most common infectious diseases affecting older adults, such as influenza, pertussis, pneumococcal disease, herpes zoster, COVID and respiratory syncytial virus (RSV). In many countries, these vaccines are recommended systematically for older adults and any adults with comorbidities, who are also those most likely to suffer from cardiovascular disease. There is a large body of evidence attesting to the benefits of vaccination on cardio- and cerebrovascular health. The European Interdisciplinary Council for Aging (EICA) and the Italian Society for Cardiovascular Prevention (Società Italiana per la Prevenzione Cardiovascolare, SIPREC) convened a 2-day meeting in June 2024 to review the state of the evidence on the relationship between cardio- and cerebrovascular health and the most common infectious diseases, and the role of vaccines in preventing both infection and its adverse consequences in terms of cardiovascular and cerebrovascular outcomes. We present here the Executive Summary of the proceedings of this meeting.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02968-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}