Aging Clinical and Experimental Research最新文献

{"title":"Association between dynapenic abdominal obesity and arthritis among the middle-aged and older Chinese: a longitudinal study","authors":"Shengliang Zhou,&nbsp;Naijia Luo,&nbsp;Haibo Si,&nbsp;Wacili Da,&nbsp;Yuan Liu,&nbsp;Limin Wu,&nbsp;Mingyang Li,&nbsp;Bin Shen","doi":"10.1007/s40520-024-02847-y","DOIUrl":"10.1007/s40520-024-02847-y","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to assess the longitudinal association between dynapenic abdominal obesity and new-onset arthritis among the middle-aged and older Chinese population.</p><h3>Methods</h3><p>We included 6863 participants from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS). Dynapenia was defined as handgrip strength &lt; 28 kg for males, and &lt; 18 kg for females. Abdominal obesity was defined as a waist circumference ≥ 90 cm for males and ≥ 85 cm for females. Based on the definitions, all participants were divided into four groups: no dynapenia and no abdominal obesity (ND/NAO), abdominal obesity alone (ND/AO), dynapenia alone (D/NAO), and dynapenia and abdominal obesity (D/AO). The association between dynapenic abdominal obesity and new-onset arthritis was assessed by sex using the Poisson regression models.</p><h3>Results</h3><p>After a four-year follow-up, 1272 (18.53%) participants reported new-onset arthritis. Those in the D/AO group had a significantly increased risk of new-onset arthritis compared to those in the ND/NAO group (adjusted relative risk (RR): 1.34, 95% confidence interval (CI): 1.01–1.77). In females, the ND/AO (RR: 1.21, 95% CI: 1.03–1.43) and D/AO (RR: 1.39, 95% CI: 1.01–1.93) groups were associated with a higher risk of arthritis. This significant association was not observed in males.</p><h3>Conclusions</h3><p>Our results indicated that the combined effect of dynapenia and abdominal obesity significantly increased the risk of new-onset arthritis in females, but this association was not observed in males.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms","authors":"Antonio Martocchia,&nbsp;Manuela Stefanelli,&nbsp;Maurizio Gallucci,&nbsp;Marianna Noale,&nbsp;Stefania Maggi,&nbsp;Maurizio Cassol,&nbsp;Demetrio Postacchini,&nbsp;Antonella Proietti,&nbsp;Mario Barbagallo,&nbsp;Ligia J. Dominguez,&nbsp;Claudio Ferri,&nbsp;Giovambattista Desideri,&nbsp;Lavinia Toussan,&nbsp;Francesca Pastore,&nbsp;Giulia M. Falaschi,&nbsp;Giuseppe Paolisso,&nbsp;Paolo Falaschi,&nbsp;The AGICO Investigators","doi":"10.1007/s40520-024-02849-w","DOIUrl":"10.1007/s40520-024-02849-w","url":null,"abstract":"<div><h3>Background</h3><p>The mechanisms at the basis of depression are still matter of debate, but several studies in the literature suggest common pathways with dementia (genetic predispositions, metabolic and inflammatory mechanisms, neuropathological changes) and other geriatric syndromes.</p><h3>Aims</h3><p>To evaluate the role of cortisol (as marker of the HPA, hypothalamus–pituitary–adrenal axis hyperactivity) in elderly subjects with depressive symptoms (by the means of the AGICO, AGIng and COrtisol, study), in relationship to the presence of the major geriatric syndromes.</p><h3>Methods</h3><p>The AGICO study enrolled patients from ten Geriatric Units in Italy. Every subject received a comprehensive geriatric assessment or CGA (including the Mini Mental State Examination or MMSE, Geriatric Depression Scale or GDS and Cornell Scale for Depression in Dementia or CSDD), the neurological examination (with a computed tomography scan or magnetic resonance imaging of the brain), the assessment of the metabolic syndrome (MetS), the evaluation of the cortisol activity by two consecutive urine collections (diurnal and nocturnal), a CGA-derived frailty index (FI) and a modified measure of allostatic load (AL).</p><h3>Results</h3><p>The MMSE scores were significantly and inversely related to the values of GDS (p &lt; 0.001) and CSDD (p &lt; 0.05), respectively. The patients with depressive symptoms (GDS/CSDD &gt; 8) showed significantly increased disability, MetS, inflammation, FI and AL and significantly reduced MMSE and renal function.</p><p>The diurnal and nocturnal urinary cortisol levels in the patients with depressive symptoms (GDS/CSDD &gt; 8) were higher with respects to controls (p &lt; 0.05 for nocturnal difference).</p><h3>Discussion</h3><p>The AGICO study showed that the stress response is activated in the patients with depression.</p><h3>Conclusion</h3><p>The depression in elderly patient should be reconsidered as a systemic disease, with coexisting major geriatric syndromes (disability, dementia, frailty) and combined pathogenetic mechanisms (metabolic syndrome, impaired renal function, low-grade inflammation, and allostatic load). Cortisol confirmed its role as principal mediator of the aging process in both dementia and metabolic syndrome.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which stakeholders should be addressed to promote Geriatric Medicine among healthcare professionals, educationalists and policy-makers in European countries? – the PROGRAMMING COST 21,122 action experience","authors":"Sumru Savas,&nbsp;Nilufer Demiral Yilmaz,&nbsp;Marina Kotsani,&nbsp;Karolina Piotrowicz,&nbsp;Sofia Duque","doi":"10.1007/s40520-024-02841-4","DOIUrl":"10.1007/s40520-024-02841-4","url":null,"abstract":"<div><h3>Background</h3><p>Geriatric Medicine (GM), concerned with well-being and health of older adults, can play a crucial role in the alignment of healthcare systems to the needs of the aged populations. However, countries have varying GM development backgrounds. The goal of PROGRAMMING- COST 21,122 Action is to propose the content of education and training activities in GM for healthcare professionals across various clinical settings, adapted to local context, needs, and assets. Defining relevant stakeholders and addressing them on both an international as well as a country-specific level is crucial for this purpose. In this paper we are describing the methods used in the PROGRAMMING Action 21,122 to map the different categories of stakeholders to be engaged in the Action.</p><h3>Methods</h3><p>Through conceptualizing a model for stakeholders by literature research, and online discussion group meetings, a synthesis for the potential stakeholders was defined as a template, and pilot applications were requested from participant countries.</p><h3>Results</h3><p>There were 24 members from 14 countries (6 males/18 females) of multidisciplinary professions involved in this study. A model for the list of stakeholders to be addressed was developed and, after seven online discussion meetings, a consensus framework was provided. Invited countries completed the templates to pilot such operationalization.</p><h3>Conclusion</h3><p>Our framework of stakeholders will support the research coordination and capacity-building objectives of PROGRAMMING, including the participation into the assessment of educational needs of healthcare professionals. Identified stakeholders will also be mobilized for purposes of dissemination and maximization of the Action’s impact. By defining and mapping multidisciplinary stakeholders involved in older people’s care specific to countries, particularly where GM is still emerging, GM tailored educational activities will be facilitated and optimally targeted.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted vs. laparoscopic right hemicolectomy in octogenarians and nonagenarians: an analysis of the US nationwide inpatient sample 2005–2018","authors":"Chien-Chang Lu,&nbsp;Chi-Tung Lu,&nbsp;Kai-Yen Chang,&nbsp;Wang Chun-Li,&nbsp;Chien-Ying Wu","doi":"10.1007/s40520-024-02833-4","DOIUrl":"10.1007/s40520-024-02833-4","url":null,"abstract":"<div><h3>Background</h3><p>Colorectal cancer (CRC) is a significant health concern, particularly among older adults. Outcomes between laparoscopic and robot-assisted surgeries for right-sided colon cancers in the oldest old population have yet to be evaluated despite increased use of these surgeries.</p><h3>Aim</h3><p>This study aimed to compare clinical outcomes after robot-assisted right hemicolectomy (RARH) versus laparoscopic right hemicolectomy (LRH) in octogenarian and nonagenarian patients.</p><h3>Methods</h3><p>This population-based, retrospective and observational study analyzed the data of adults ≥ 80 years old diagnosed with right-side colon cancer who received RARH or LRH. All data were extracted from the US National Inpatient Sample (NIS) database 2005–2018. Associations between type of surgery and in-hospital outcomes were determined using univariate and multivariable logistic regression and linear regression analysis.</p><h3>Results</h3><p>Data of 7,550 patients (representing 37,126 hospitalized patients in the U.S.) were analyzed. Mean age of the study population was 84.8 years, 61.4% were females, and 79.1% were non-smokers. After adjusting for relevant confounders, regression analysis showed that patients undergoing RARH had a significantly shorter LOS (adjusted Beta (aBeta), -0.24, 95% CI: -0.32, -0.15) but greater total hospital costs (aBeta, 26.54, 95% CI: 24.64, 28.44) than patients undergoing LRH. No significant differences in mortality, perioperative complications, and risk of unfavorable discharge were observed between the two procedures (<i>p</i> &gt; 0.05). Stratified analyses by frailty status revealed consistent results.</p><h3>Conclusions</h3><p>RARH is associated with a significantly shorter LOS but higher total hospital costs than LRH among octogenarians and nonagenarians. Other short-term outcomes for this population are similar between the two procedures, including in-hospital mortality, perioperative complications, and unfavorable discharge. These findings also apply to frail patients.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Prevention at home in older persons with (pre-)frailty: analysis of participants’ recruitment and characteristics of the randomized controlled PromeTheus trial","authors":"Tim Fleiner,&nbsp;Corinna Nerz,&nbsp;Michael Denkinger,&nbsp;Jürgen M. Bauer,&nbsp;Christian Grüneberg,&nbsp;Judith Dams,&nbsp;Martina Schäufele,&nbsp;Gisela Büchele,&nbsp;PromeTheus Study Group,&nbsp;Kilian Rapp,&nbsp;Christian Werner","doi":"10.1007/s40520-024-02837-0","DOIUrl":"10.1007/s40520-024-02837-0","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contribution of cognitive reserve in explaining the dual-task walking performance in iNPH patients: comparison with other cognitive, functional, and socio-demographic variables","authors":"Elodie Piche,&nbsp;Stephane Armand,&nbsp;Gilles Allali,&nbsp;Frederic Assal","doi":"10.1007/s40520-024-02829-0","DOIUrl":"10.1007/s40520-024-02829-0","url":null,"abstract":"<div><h3>Background</h3><p>Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent neurological disorder, but its diagnosis remains challenging. Dual-task (DT) walking performance is a reliable indicator of iNPH but less is known about the role of cognitive reserve (CR) in predicting DT walking performance.</p><h3>Aims</h3><p>The objective of this study was to evaluate the contribution of CR on DT walking in healthy controls (HC) and in iNPH patients (iNPH-P).</p><h3>Methods</h3><p>68 iNPH-P (77.2 +/- 6.7 years old) and 28 HC (74.5 +/- 5.7 years old) were evaluated on their single-task walking (<i>Vsimple</i>) and on 4 DT walking (walking and counting or counting backwards, naming animals, naming words beginning with the letter P) (<i>Vcount</i>,<i> VcountB</i>,<i> Vanimals and Vletter</i> respectively). The contribution of CR on the different DT walking speeds was compared between HC and iNPH-P. In iNPH-P, the contribution of CR on the walking speeds was compared with regard to other cognitive, functional, and socio-demographic variables.</p><h3>Results</h3><p>Simple linear regression demonstrated a moderate influence of CR on single and DT walking speed in iNPH-P (β &gt; 0.3, <i>p</i> &lt; .001) but not in HC where the relation was not significant. In iNPH-P, results showed that CR played a major role in explaining each of the single and DT walking speeds with NPH-scale.</p><h3>Conclusion</h3><p>As CR could be improved through the life cycle, these results support the idea of developing and supporting physical activity programs that will enrich social, physical, and cognitive resources to protect against age-related functional decline, especially in iNPH-P patients where the age-related deficits are greater.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02829-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study","authors":"Zuying Liu,&nbsp;Jiaming Fan,&nbsp;Huilian Bu,&nbsp;Lijun Fu,&nbsp;Cong Li,&nbsp;Letian Ma,&nbsp;Cunlong Kong,&nbsp;Zhongyuan Lu,&nbsp;Xinxin Li,&nbsp;Jian Wang,&nbsp;Qingying Liu,&nbsp;Jingjing Yuan,&nbsp;Xiaochong Fan","doi":"10.1007/s40520-024-02843-2","DOIUrl":"10.1007/s40520-024-02843-2","url":null,"abstract":"<div><h3>Background</h3><p>Previous observational studies have revealed a potentially robust bidirectional relationship between frailty and low back pain (LBP). However, the precise causal relationship remains unclear.</p><h3>Methods</h3><p>To examine the potential causal association between frailty and LBP, we conducted bidirectional two-sample Mendelian randomization analysis (MR) study. Genetic data on frailty index (FI) and LBP were acquired from publicly available genome-wide association studies (GWAS). Various MR methodologies were utilized, such as inverse variance weighting (IVW), weighted median, and MR-Egger, to evaluate causality. Additionally, sensitivity analyses were conducted to evaluate the robustness of the findings.</p><h3>Results</h3><p>Genetically predicted higher FI (IVW, odds ratio [OR] = 1.66, 95% CI 1.17–2.36, <i>p</i> = 4.92E-03) was associated with a higher risk of LBP. As for the reverse direction, genetic liability to LBP showed consistent associations with a higher FI (IVW, OR = 1.13, 95% CI 1.07–1.19, <i>p</i> = 2.67E-05). The outcomes from various MR techniques and sensitivity analyses indicate the robustness of our findings.</p><h3>Conclusion</h3><p>Our research findings provide additional evidence bolstering the bidirectional causal relationship between frailty and LBP.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02843-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between physical activity and delayed neurocognitive recovery in elderly patients: a mediation analysis of pro-inflammatory cytokines","authors":"Junfang Niu,&nbsp;Yanan Li,&nbsp;Qi Zhou,&nbsp;Xiang Liu,&nbsp;Peixia Yu,&nbsp;Fang Gao,&nbsp;Xia Gao,&nbsp;Qiujun Wang","doi":"10.1007/s40520-024-02846-z","DOIUrl":"10.1007/s40520-024-02846-z","url":null,"abstract":"<div><h3>Background</h3><p>Delayed neurocognitive recovery (dNCR) can result in unfavorable outcomes in elderly surgical patients. Physical activity (PA) has been shown to improve cognitive function, potentially by reducing systemic inflammatory responses. However, there is a lack of supportive data indicating whether PA has a protective effect against dNCR.</p><h3>Aims</h3><p>To examine the correlation between dNCR and PA, and to further analyze if pro-inflammatory cytokines mediate this relationship.</p><h3>Methods</h3><p>This study is a prospective nested case-control investigation of elderly patients who had knee replacement surgery. dNCR was defined as a decline in cognitive function compared with baseline by using a battery of neuropsychological tests. PA was assessed with the Physical Activity Scale for the Elderly (PASE). Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum concentrations of IL-6, IL-1β, and TNF-α. Multivariable logistic regression analysis was conducted to assess the association between PA and dNCR. Mediation analysis was employed to evaluate whether pro-inflammatory cytokines mediate the relationship between them.</p><h3>Results</h3><p>A cohort of 152 patients was included, resulting in an incidence rate of dNCR of 23.68%. PA was associated with dNCR after full adjustment [OR = 0.199, (95% CI, 0.061; 0.649), <i>P</i> = 0.007]. Mediation analysis showed that the IL-6 mediated the statistical association between PA and dNCR, with mediation proportions (%) of 77.68 (postoperative concentration of IL-6) or 27.58 (the absolute change in IL-6 before and after surgery).</p><h3>Conclusions</h3><p>PA serves as a protective factor against dNCR, possibly through the reduction of pro-inflammatory cytokine concentrations.</p><h3>The Chinese Clinical Trail Registry</h3><p>: www.http://chictr.org.cn, Registration No. ChiCTR2300070834, Registration date: April 24, 2023.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02846-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pre-stroke frailty status and stroke risk and impact on outcomes: a systematic review and meta-analysis of 1,660,328 participants","authors":"Shu-Fan Chen,&nbsp;Hai-Han Li,&nbsp;Zi-Ning Guo,&nbsp;Ke-Yu Ling,&nbsp;Xiao-Li Yu,&nbsp;Fei Liu,&nbsp;Xiao-Ping Zhu,&nbsp;Xiaoping Zhu","doi":"10.1007/s40520-024-02845-0","DOIUrl":"10.1007/s40520-024-02845-0","url":null,"abstract":"<div><p>The prevalence of frailty is increasing, and it is associated with increased risk of diseases and adverse outcomes. Although substantial research has focused on post-stroke frailty, understanding of pre-stroke frailty remains limited. Our aim was to synthesize literature on pre-stroke frailty and stroke risk to explore their relationship and impact on prognosis. A systematic search of multiple databases was conducted to identify cohort studies published until October 28, 2023. Meta-analysis was conducted using a random effects model. Heterogeneity was assessed with the I² statistic, and publication bias was evaluated using Begg’s test. Finally, we included 11 studies (<i>n</i> = 1,660,328 participants). The pooled hazard ratios (HRs) for stroke risk associated with pre-stroke frailty compared to non-frail individuals was 1.72 (95% confidence interval, CI: 1.46–2.02, <i>p</i> = 0.002, <i>I</i>^<i>2</i> = 69.2%, Begg’s test: <i>p</i> = 0.536). The pooled HRs for mortality and the pooled relative risk (RRs) modified Rankin Scale (mRs) associated with pre-stroke frailty were 1.68 (95% CI: 1.10–2.56, <i>p</i> = 0.136, <i>I</i>^<i>2</i> = 49.9%, Begg’s test: <i>p</i> = 0.296) and 3.11 (95% CI: 1.77–5.46, <i>p</i> = 0.192, <i>I</i>^<i>2</i> = 39.4%, Begg’s test: <i>p</i> = 1.000), respectively. In conclusion, pre-stroke frailty is strongly associated with stroke risk and impacts its prognosis, irrespective of the measurement method. Future research should focus on prospective studies to assess the effects of early intervention for frailty. This has significant implications for primary healthcare services and frailty management.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02845-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and future estimates of frailty and pre-frailty in a population-based sample of people 70 years and older in Norway: the HUNT study","authors":"Ingebjørg Lavrantsdatter Kyrdalen,&nbsp;Bjørn Heine Strand,&nbsp;Geir Selbæk,&nbsp;Pernille Thingstad,&nbsp;Heidi Ormstad,&nbsp;Emiel O. Hoogendijk,&nbsp;Håvard Kjesbu Skjellegrind,&nbsp;Gro Gujord Tangen","doi":"10.1007/s40520-024-02839-y","DOIUrl":"10.1007/s40520-024-02839-y","url":null,"abstract":"<div><h3>Background</h3><p>Frailty in older people is a rising global health concern; therefore, monitoring prevalence estimates and presenting projections of future frailty are important for healthcare planning.</p><h3>Aim</h3><p>To present current prevalence estimates of frailty and pre-frailty and future projections according to both dominant frailty models in a large population-based observational study including adults ≥ 70 years in Norway.</p><h3>Methods</h3><p>In this population-based observational study, we included 9956 participants from the HUNT4 70 + study, conducting assessments at field stations, homes, and nursing homes. Frailty was assessed using Fried criteria and a 35-item frailty index (HUNT4-FI). Inverse probability weighting and calibration using post-stratification weights and aggregated register data for Norway according to age, sex, and education ensured representativeness, and population projection models were used to estimate future prevalence.</p><h3>Results</h3><p>According to Fried criteria, the current prevalence rates of frailty and pre-frailty in people ≥ 70 years were 10.6% and 41.9%, respectively, and for HUNT4-FI 35.8% and 33.2%, respectively. Compared to previous European estimates we identified higher overall frailty prevalence, but lower prevalence in younger age groups. Projections suggest the number of Norwegian older adults living with frailty will close to double by 2040.</p><h3>Conclusion</h3><p>Frailty in older people in Norway is more prevalent than previous European estimates, emphasising the imperative for effective interventions aimed to delay and postpone frailty and ensure healthcare system sustainability in an ageing population. Future planning should consider the great heterogeneity in health and functioning within the 70 + population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02839-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}