Aging Clinical and Experimental Research最新文献

{"title":"Predictive value of geriatric nutritional risk indexes for hospital readmission and mortality in older patients","authors":"Yajun Chen,&nbsp;Jin Wei,&nbsp;Ming Zhang,&nbsp;Dongping Xu,&nbsp;Yuheng Lang,&nbsp;Yumei Qi","doi":"10.1007/s40520-024-02899-0","DOIUrl":"10.1007/s40520-024-02899-0","url":null,"abstract":"<div><p>The Geriatric Nutritional Risk Index (GNRI) plays a crucial role in assessing nutritional status and predicting clinical outcomes in older patients. This study explores the GNRI as a prognostic tool for clinical outcomes in older inpatients. Spanning from August 2013 to December 2020, the research involved 573 older patients at Tianjin Third Central Hospital, China. The study assessed the association of GNRI with 6-month hospital readmission and 3-year all-cause mortality rates. Our findings reveal that higher GNRI scores significantly correlate with reduced hospital readmissions and mortality, underscoring the utility of GNRI in predicting clinical outcomes and guiding interventions in geriatric care. The study highlights the potential of integrating GNRI assessments into routine clinical evaluations to enhance patient care and optimize resource utilization in healthcare settings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02899-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia diagnosed by computed tomography predicts postoperative complications in advanced epithelial ovarian cancer","authors":"Shuyue Su,&nbsp;Rongrong Shao,&nbsp;Mengxiao Sun,&nbsp;Jingying Bai,&nbsp;Haote Jiang,&nbsp;Yuyang Zhang","doi":"10.1007/s40520-024-02901-9","DOIUrl":"10.1007/s40520-024-02901-9","url":null,"abstract":"<div><h3>Background &amp; aims</h3><p>Surgery combined with chemotherapy remains the mainstay of treatment for advanced epithelial ovarian cancer. It is important to evaluate the occurrence of postoperative complications before operation and to prevent them. The purpose of this study is to investigate the role of sarcopenia diagnosed by CT scans in predicting postoperative complications in patients with ovarian cancer.</p><h3>Methods</h3><p>Patients with PDS or IDS in the First Affiliated Hospital of Wenzhou Medical University from August 2017 to August 2022 were included. Sarcopenia was identified using CT scans at the T12 level. According to the Clavien-Dindo classification, postoperative complications are considered to have occurred in grades 2 and above. Logistic regression analysis was used to identify risk factors contributing to postoperative complications. <i>P</i> &lt; 0.05 was considered statistically significant.</p><h3>Results</h3><p>A total of 139 patients were included. Sarcopenia was observed in 24(17.27%) patients with advanced epithelial ovarian cancer. Compared to the non-sarcopenia group, the sarcopenia group had a higher incidence of postoperative complications (62.50% VS 42.61%, <i>p</i> = 0.032). Multivariate logistic analysis confirmed sarcopenia (OR = 3.241, <i>p</i> = 0.026), age over 65 years (OR = 3.296, <i>p</i> = 0.005), and intraoperative bleeding (OR = 1.002, <i>p</i> &lt; 0.001) as independent predictors of postoperative complications in ovarian cancer.</p><h3>Discussion &amp; conclusions</h3><p>Sarcopenia diagnosed based on CT body composition analysis may serve as a potential predictor for postoperative complications. Further research is warranted to explore preventive strategies and interventions to improve outcomes in this population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02901-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of osteosarcopenia on musculoskeletal health, risks of falls and fractures, and activities of daily living among population aged 50 and above: an age- and sex-matched cross-sectional analysis","authors":"Bao Tu Thai Nguyen,&nbsp;Ashleigh Peng Lin,&nbsp;Wan-Wan Yang,&nbsp;Shun-Jen Cheng,&nbsp;Yi-Jie Kuo,&nbsp;Tan Thanh Nguyen,&nbsp;Yu-Pin Chen","doi":"10.1007/s40520-024-02902-8","DOIUrl":"10.1007/s40520-024-02902-8","url":null,"abstract":"<div><h3>Aims</h3><p>We conducted this study to investigate the impact of muscle loss on musculoskeletal health, fall and fracture risks, and activities of daily living (ADL) in elderly patients with osteoporosis.</p><h3>Materials and methods</h3><p>This age- and sex-matched cross-sectional study analyzed data from a medical center involving patients aged ≥ 50 from 2020 to 2022. The included participants were formed into three groups: 100 with osteoporosis only, 100 with osteosarcopenia, and 50 control individuals without osteoporosis and sarcopenia. We compared groups based on their baseline characteristics, bone and muscle health measurements, and the risks of falls and fractures using the STRATIFY scale and FRAX, respectively. Additionally, ADL was assessed using the Barthel Index. A multivariate analysis was performed to identify factors associated with declined ADL in osteosarcopenic patients.</p><h3>Results</h3><p>The mean age was 76.17 years, and 82% were female. The osteosarcopenic group demonstrated poorer bone and muscle quality and quantity, with greater risks of major osteoporotic-related fractures, hip fractures, and falls, as well as significantly decreased ADL than other groups. When comparing sexes, females exhibited worse performance than males across groups. Slow gait speed and high STRATIFY score are independent predictors of declined ADL in osteosarcopenic patients.</p><h3>Conclusion</h3><p>Sarcopenia exacerbates osteoporotic patients, particularly women, worsening bone deterioration, increasing fall and fracture risks, and significantly impairing daily activities. Enhancing walking speed and reducing fall risk can boost independence in individuals with osteosarcopenia. Early detection, proper management, and preventive measures are essential for mitigating these adverse outcomes in high-risk individuals.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02902-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social engagement decline and cognitive function changes: mediating effect of depressive symptoms","authors":"Ping Ni,&nbsp;Hongxiu Chen,&nbsp;Xiuying Hu","doi":"10.1007/s40520-024-02897-2","DOIUrl":"10.1007/s40520-024-02897-2","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive decline is a significant public health problem worldwide, but little is known about social engagement’s impact on cognitive changes over time. This study aimed to explore the relationship between social engagement decline and cognitive function change in Chinese adults, and to analyze the effect of changes in depressive symptoms on this relationship.</p><h3>Methods</h3><p>Participants were selected from the China Health and Retirement Longitudinal Study. Multiple linear regression was conducted to determine the association between social engagement decline and cognitive function changes, and a three-step method was used to test the mediating role of changes in depressive symptoms.</p><h3>Results</h3><p>During the four-year follow-up, participants’ overall cognitive function decreased by an average of 0.41 points (3.0%). The decline in social engagement was significantly associated with subsequent poorer global cognitive function (Model 1: β = − 0.060, <i>P</i> =.005; Model 2: β = − 0.056, <i>P</i> =.009), and changes in depressive symptoms partially mediated this effect, accounting for 15.3% of the total effect in Model 1 and 13.8% in Model 2. Model 1 adjusted for sociodemographic characteristics, and Model 2 adjusted for health-related factors based on Model 1.</p><h3>Conclusion</h3><p>When developing programs for cognitive improvement in middle-aged and older adults, measures to enhance social engagement should be considered. This may not only reduce depressive symptoms but also help to minimize cognitive decline.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02897-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal association between asthma and the risk of frailty: A two-sample Mendelian randomization study","authors":"Pingping Ning,&nbsp;Xin Mu,&nbsp;Xingzhi Guo,&nbsp;Rong Zhou,&nbsp;Ge Tian,&nbsp;Rui Li","doi":"10.1007/s40520-024-02906-4","DOIUrl":"10.1007/s40520-024-02906-4","url":null,"abstract":"<div><h3>Background</h3><p>The correlation between asthma and frailty is increasingly garnering attention. The association between asthma and frailty remains inconclusive in observational studies, and the causality of this relationship still needs to be established.</p><h3>Aims</h3><p>Therefore, we employed two-sample Mendelian randomization analyses using genetic instruments to determine the causal association of asthma on frailty.</p><h3>Methods</h3><p>Two-sample Mendelian randomization (MR) analyses were performed to assess the causal effect of asthma on frailty. The genetic variants strongly associated with asthma (<i>P</i> &lt; 5E-08) during the discovery and replication stages were derived from a recent meta-analysis of genome-wide association studies (GWAS) (N = 408,442) in the UK Biobank and a GWAS in the FinnGen Consortium (N = 217,421), respectively. Summary statistics of the frailty index (N = 175,226) are derived from the latest released GWAS dataset on frailty index. The inverse variance weighted (IVW) method was employed as the primary approach for calculating estimated values, with additional sensitivity analyses and heterogeneity analyses utilized to further validate the results.</p><h3>Results</h3><p>Using the IVW method, genetic susceptibility to asthma was associated with an increased risk of frailty in the discovery stage (odds ratio [OR] = 1.092, 95% confidence interval [CI] = 1.075–1.109, <i>P</i> = 5.00E-28), which was also validated in the replication stage (OR = 1.073, 95% CI = 1.052–1.096, <i>P</i> = 1.41E-11). Sensitivity analyses yielded consistent causal estimate, and no significant pleiotropy was found throughout the MR study.</p><h3>Conclusion</h3><p>The present study demonstrated that asthma is causally associated with an elevated risk of frailty. Further studies are needed to elucidate the potential pathophysiological mechanisms between asthma and frailty.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02906-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a prediction model for Alzheimer’s disease using an AI-driven eye-tracking task on mobile devices","authors":"Qinjie Li,&nbsp;Jiaxin Yan,&nbsp;Jianfeng Ye,&nbsp;Hao Lv,&nbsp;Xiaochen Zhang,&nbsp;Zhilan Tu,&nbsp;Yunxia Li,&nbsp;Qihao Guo","doi":"10.1007/s40520-024-02882-9","DOIUrl":"10.1007/s40520-024-02882-9","url":null,"abstract":"<div><h3>Background</h3><p>Eye-movement can reflect cognition and provide information on the neurodegeneration, such as Alzheimer’s disease (AD). The high cost and limited accessibility of eye-movement recordings have hindered their use in clinics.</p><h3>Aims</h3><p>We aim to develop an AI-driven eye-tracking tool for assessing AD using mobile devices with embedded cameras.</p><h3>Methods</h3><p>166 AD patients and 107 normal controls (NC) were enrolled. The subjects completed eye-movement tasks on a pad. We compared the demographics and clinical features of two groups. The eye-movement features were selected using least absolute shrinkage and selection operator (LASSO). Logistic regression (LR) model was trained to classify AD and NC, and its performance was evaluated. A nomogram was established to predict AD.</p><h3>Results</h3><p>In training set, the model showed a good area under curve (AUC) of 0.85 for identifying AD from NC, with a sensitivity of 71%, specificity of 84%, positive predictive value of 0.87, and negative predictive value of 0.65. The validation of the model also yielded a favorable discriminatory ability with the AUC of 0.91, sensitivity, specificity, positive predictive value, and negative predictive value of 82%, 91%, 0.93, and 0.77 to identify AD patients from NC.</p><h3>Discussion and Conclusions</h3><p>This novel AI-driven eye-tracking technology has the potential to reliably identify differences in eye-movement abnormalities in AD. The model shows excellent diagnostic performance in identifying AD based on the current data collected. The use of mobile devices makes it accessible for AD patients to complete tasks in primary clinical settings or follow up at home.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02882-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry for the diagnosis of sarcopenia in the older adults with metabolic syndrome: equipment-specific equation development","authors":"Younji Kim,&nbsp;Jaewon Beom,&nbsp;Sang Yoon Lee,&nbsp;Hak Chul Jang,&nbsp;Keewon Kim,&nbsp;Miji Kim,&nbsp;Ga Yang Shim,&nbsp;Chang Won Won,&nbsp;Jae-Young Lim","doi":"10.1007/s40520-024-02898-1","DOIUrl":"10.1007/s40520-024-02898-1","url":null,"abstract":"<div><h3>Objective</h3><p>Metabolic syndrome (MetS) and sarcopenia together pose significant health risks, increasing frailty, falls, and fractures in older adults. This study compared muscle mass measurements obtained using two different dual-energy X-ray absorptiometry (DXA) machines and bioelectrical impedance analysis (BIA), and evaluated the accuracy of these measurements in these older adults.</p><h3>Methods</h3><p>In this prospective multicenter cohort study, patients aged ≥ 65 years with MetS had their muscle mass assessed using both BIA and DXA. Two DXA devices, Hologic Horizon and GE Lunar Prodigy, were used as clinical standards for sarcopenia diagnosis. Statistical analyses generated equations for transforming BIA results to match those from DXA, enhancing comparability.</p><h3>Results</h3><p>Participants had a mean age of 73.2 ± 5.3 years. The mean appendicular skeletal muscle mass (ASM) measured by BIA and DXA was 19.7 ± 3.1 kg (BIA) and 18.1 ± 2.9 kg (DXA) for males, and 13.7 ± 2.2 kg (BIA) and 12.6 ± 1.8 kg (DXA) for females. Device-specific equations were developed to estimate DXA-measured ASM based on BIA results. These equations are presented for all participants and for each DXA device, highlighting significant differences in prediction models between the two DXA machines.</p><h3>Conclusion</h3><p>The study developed device-specific equations for sarcopenia diagnosis in older adults with MetS, highlighting substantial differences between Hologic and GE Lunar devices. While BIA may offer a more accessible alternative to DXA, the variation in prediction formulas underscores the need for standardized equipment to ensure consistency in sarcopenia diagnosis.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02898-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dementia and mild cognitive impairment on bone health in older people","authors":"Elizabeth M. Curtis,&nbsp;Mario Miguel,&nbsp;Claire McEvoy,&nbsp;Andrea Ticinesi,&nbsp;Carla Torre,&nbsp;Nasser Al-Daghri,&nbsp;Majed Alokail,&nbsp;Ewa Bałkowiec-Iskra,&nbsp;Olivier Bruyère,&nbsp;Nansa Burlet,&nbsp;Etienne Cavalier,&nbsp;Francesca Cerreta,&nbsp;Patricia Clark,&nbsp;Antonio Cherubini,&nbsp;Cyrus Cooper,&nbsp;Patrizia D’Amelio,&nbsp;Nicholas Fuggle,&nbsp;Celia Gregson,&nbsp;Philippe Halbout,&nbsp;John A. Kanis,&nbsp;Jean Kaufman,&nbsp;Andrea Laslop,&nbsp;Stefania Maggi,&nbsp;Andrea Maier,&nbsp;Radmila Matijevic,&nbsp;Eugene McCloskey,&nbsp;Sif Ormarsdóttir,&nbsp;Concha Prieto Yerro,&nbsp;Régis P. Radermecker,&nbsp;Yves Rolland,&nbsp;Andrea Singer,&nbsp;Nicola Veronese,&nbsp;René Rizzoli,&nbsp;Jean-Yves Reginster,&nbsp;Nicholas C. Harvey","doi":"10.1007/s40520-024-02871-y","DOIUrl":"10.1007/s40520-024-02871-y","url":null,"abstract":"<div><p>Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly ageing global population, are increasing in prevalence. These conditions are closely associated, with shared risk factors, common underlying biological mechanisms and potential direct causal pathways. In this review, the epidemiological and mechanistic links between mild cognitive impairment, dementia and skeletal health are explored. Discussion will focus on how changes in brain and bone signalling can underly associations between these conditions, and will consider the molecular and cellular drivers in the context of inflammation and the gut microbiome. There is a complex interplay between nutritional changes, which may precede or follow the onset of mild cognitive impairment (MCI) or dementia, and bone health. Polypharmacy is common in patients with MCI or dementia, and there are difficult prescribing decisions to be made due to the elevated risk of falls associated with many drugs used for associated problems, which can consequently increase fracture risk. Some medications prescribed for cognitive impairment may directly impact bone health. In addition, patients may have difficulty remembering medication without assistance, meaning that osteoporosis drugs may be prescribed but not taken. Cognitive impairment may be improved or delayed by physical activity and exercise, and there is evidence for the additional benefits of physical activity on falls and fractures. Research gaps and priorities with the aim of reducing the burden of osteoporosis and fractures in people with MCI or dementia will also be discussed.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02871-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes from robotic transabdominal preperitoneal inguinal hernia repair in patients under and over 70 years old: a single institution retrospective cohort study with a comprehensive systematic review on behalf of TROGSS - The Robotic Global Surgical Society","authors":"Yeisson Rivero-Moreno,&nbsp;Aman Goyal,&nbsp;Samantha Redden-Chirinos,&nbsp;Halil Bulut,&nbsp;Rebeca Dominguez-Profeta,&nbsp;Pujita Munnangi,&nbsp;Jason Shenoi,&nbsp;Paulamy Ganguly,&nbsp;Pierre Blanc,&nbsp;Khalid Alkadam,&nbsp;Sjaak Pouwels,&nbsp;Safwan Taha,&nbsp;Beniamino Pascotto,&nbsp;Juan Santiago Azagra,&nbsp;Wah Yang,&nbsp;Andrea Garcia,&nbsp;Kathia Dayana Morfin-Meza,&nbsp;Clotilde Fuentes-Orozco,&nbsp;Alejandro González-Ojeda,&nbsp;Luis Osvaldo Suárez-Carreón,&nbsp;Luigi Marano,&nbsp;Adel Abou-Mrad,&nbsp;Rodolfo J. Oviedo","doi":"10.1007/s40520-024-02890-9","DOIUrl":"10.1007/s40520-024-02890-9","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to assess and compare outcomes of robotic inguinal hernia repair (RIHR) in patients under and over 70 years old, performed by a fellowship-trained robotic surgeon at a single institution.</p><h3>Methods</h3><p>A retrospective analysis of patients undergoing robotic primary transabdominal preperitoneal inguinal hernia repair between 2020 and 2022 was conducted. Patients were categorized into two age groups: those under 70 years and 70 years and older. Data were collected through chart reviews with a mean follow-up of 30 days. Concurrently, a systematic review (SR) of relevant high-level literature was carried out.</p><h3>Results</h3><p>Among the 37 patients studied, 75.7% (n = 28) were male, with a mean age of 64.8 years. Demographic features did not significantly differ based on age groups. Patients &gt; 70 years had a higher incidence of reported complications (52.3% vs. 87.5%, p &lt; 0.461). There were no differences in operative time or length of stay between the groups. In the SR, only 23.7% (n = 9) of studies provided age-related conclusions. Three studies identified age over 70 as a risk factor for postoperative complications, while two studies suggested that RIHR is feasible and safe in patients aged 80 years and older.</p><h3>Conclusion</h3><p>Patients over 70 years old demonstrated a higher incidence of complications compared to younger patients. However, current literature indicates that the robotic approach may offer a safe and minimally invasive option for inguinal hernia repair in both younger and older adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02890-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis","authors":"Hongmei Huang,&nbsp;Mengxia Lu,&nbsp;Pan Zhang,&nbsp;Lulu Xiao,&nbsp;Wanqiu Zhang,&nbsp;Yingjie Xu,&nbsp;Jinghui Zhong,&nbsp;Yiran Dong,&nbsp;Xian Chao,&nbsp;Yirong Fang,&nbsp;Jinjing Wang,&nbsp;Shiyi Jiang,&nbsp;Wusheng Zhu,&nbsp;Xinfeng Liu,&nbsp;Wen Sun","doi":"10.1007/s40520-024-02892-7","DOIUrl":"10.1007/s40520-024-02892-7","url":null,"abstract":"<div><h3>Background</h3><p>Malnutrition, post-stroke depression (PSD), post-stroke anxiety (PSA), and post-stroke fatigue (PSF) in stroke survivors have complex relationships and are associated with adverse stroke outcomes.</p><h3>Aims</h3><p>This research aims to explore the temporal and directional relationships between malnutrition, PSD, PSA, and PSF after stroke in older adults.</p><h3>Methods</h3><p>Patients aged 65 years and older with their first ischemic stroke from two centers were selected and assessed at baseline, 3 months and 12 months. Malnutrition was evaluated using the Controlling Nutritional Status (CONUT) score, the Geriatric Nutritional Risk Index (GNRI), and the Prognostic Nutritional Index (PNI). PSD, PSA and PSF were measured with 24-item Hamilton Depression Scale (HAMD-24), 14-item Hamilton Anxiety Scale (HAMA-14) and Fatigue Severity Scale (FSS), respectively. The cross-lagged panel model (CLPM) was employed to investigate the temporal and directional relationships among these variables.</p><h3>Results</h3><p>Among the 381 older patients included, 54.33%, 43.57%, and 7.87% were found to have malnutrition according to the CONUT, GNRI, and PNI scores, respectively. Significant bidirectional relationships were found between malnutrition and PSD, as well as between PSD, PSA, and PSF, but no significant bidirectional relationships between malnutrition, PSA and PSF were observed, irrespective of the malnutrition index used (CONUT, GNRI, or PNI).</p><h3>Conclusions</h3><p>Nutritional status and post-stroke neuropsychiatric disorders in older stroke survivors are worthy of attention. Specifically, early malnutrition after stroke can predict later PSD and vice versa. PSD, PSA, and PSF are mutually predictable. Further studies are required to investigate the mechanisms of these findings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02892-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}