Aging Clinical and Experimental Research最新文献

{"title":"Independent and joint associations of psychological resilience and social support with cognitive impairment among middle-aged and older Chinese adults.","authors":"Xiaoxia Wei, Fangqin Tan, Weihao Shao, Ji Zhang, Yihao Zhao, Yue Zhang, Jean-Pierre Michel, Enying Gong, Philipe de Souto Barreto, Ruitai Shao","doi":"10.1007/s40520-026-03348-w","DOIUrl":"https://doi.org/10.1007/s40520-026-03348-w","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment poses a major public health concern in ageing societies. This study investigated the independent and joint associations of resilience and social support with cognitive function among community-dwelling middle-aged and older Chinese adults, and explored gender-specific differences.</p><p><strong>Methods: </strong>A total of 3,058 Chinese adults aged ≥ 50 years from both urban and rural communities were included. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Resilience was assessed using the 10-item Connor-Davidson Resilience Scale (CD-RISC-10), and social support by the 6-item Lubben Social Network Scale (LSNS-6). Logistic regression models stratified by gender were applied with adjustment for demographic, behavioral, and health-related variables. Generalized additive models were used to test non-linear associations, and joint effects were examined with combined categories.</p><p><strong>Results: </strong>Overall, 18.4% of participants (20.1% women, 16.3% men) had cognitive impairment. Higher resilience and social support were independently associated with lower odds of cognitive impairment, with some variation in effect strength across sex, age group, and educational attainment in sensitivity and stratified analyses. Curvilinear associations were observed in generalized additive models. Compared with low resilience and low support, participants with moderate resilience and high support had the lowest risk (OR = 0.25, 95% CI: 0.11-0.51).</p><p><strong>Conclusions: </strong>Resilience and social support were independently and jointly associated with cognitive function among middle-aged and older adults. These associations appeared to be stronger in women, although variation by sex was observed. Given the cross-sectional design, the findings should be interpreted as exploratory, and further longitudinal and interventional studies are needed to clarify the role of psychosocial resources in cognitive ageing.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very short-term monitoring of Romosozumab longitudinal effects in a cohort of postmenopausal women by means of Radiofrequency Echographic Multi-Spectrometry (REMS) technology.","authors":"Angelo Semeraro, Angela Chialà, Andrea Carafa, Rosalinda Fanizzi, Elisabetta Di Tano, Maria Palmisano, Carmela Santoro, Federica Dibenedetto, Nicola Napoli","doi":"10.1007/s40520-026-03391-7","DOIUrl":"https://doi.org/10.1007/s40520-026-03391-7","url":null,"abstract":"<p><strong>Background: </strong>Romosozumab/AMG785 (Evenity^®, Amgen and UCB pharma, RMZ) is a sclerostin-neutralizing antibody that rapidly increases BMD, but very short-term monitoring in clinical routine is limited by specific issues of available ionizing techniques.</p><p><strong>Aims: </strong>To assess the effectiveness of the radiation-free Radiofrequency Echographic Multi Spectrometry (REMS) for very short-term monitoring of RMZ in postmenopausal women.</p><p><strong>Methods: </strong>Seventy-four postmenopausal women starting RMZ and 52 postmenopausal women not receiving anti-osteoporosis drugs underwent proximal femur REMS scans at baseline and after 6 months, assessing total hip (TH) and femoral neck (FN) BMD. Exploratory analyses were also performed in treatment-naïve patients and in women with ≥ 2 prior fragility fractures.</p><p><strong>Results: </strong>After six months of RMZ, BMD significantly increased at both TH (+ 3.7%; 0.718 ± 0.103 g/cm² vs. 0.698 ± 0.116 g/cm²; p < 0.01) and FN (+ 4.1%, 0.572 ± 0.092 g/cm² vs. 0.556 ± 0.105 g/cm²; p ≤ 0.01). In treatment-naïve patients (n = 33), BMD gains were larger (TH + 4.7%; FN + 4.6%), as also in women with ≥ 2 prior fractures (n = 36), where TH BMD increased by 4.1% and FN BMD by 4.8%. In untreated controls, no significant changes were observed at either TH (-0.8%; p > 0.05) or FN (-0.6%; p > 0.05). Weight and BMI did not change significantly over the considered 6-month interval.</p><p><strong>Conclusions: </strong>REMS detected clinically-relevant 6-month increases in femoral BMD during RMZ therapy, while BMD remained stable in untreated controls. These findings, together with anthropometric stability, support the feasibility of REMS for very short-term follow-up in real-world settings.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption and brain structure: a comprehensive systematic review of observational studies.","authors":"Justyna Godos, Giuseppe Caruso, Agnieszka Micek, Alberto Dolci, Zoltan Ungvari, Andrea Lehoczki, Lisandra Leon, Evelyn Frias-Toral, Andrea Di Mauro, Mario Siervo, Michelino Di Rosa, Giuseppe Grosso","doi":"10.1007/s40520-026-03363-x","DOIUrl":"https://doi.org/10.1007/s40520-026-03363-x","url":null,"abstract":"<p><strong>Background: </strong>Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel-related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking.</p><p><strong>Aims: </strong>The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies.</p><p><strong>Methods: </strong>Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations.</p><p><strong>Results: </strong>A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet).</p><p><strong>Conclusions: </strong>Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac resynchronization therapy in very old patients with pacemakers: a cardiogeriatric, physiology-based approach.","authors":"Rémi Esser, Marc Harboun, Alejandro Mondragon, Marine Larbaneix, Christine Farges, Marlène Esteban, Vincenzo Palermo, Sophie Nisse Durgeat, Olivier Maurou, David Perrot","doi":"10.1007/s40520-026-03393-5","DOIUrl":"https://doi.org/10.1007/s40520-026-03393-5","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory research on cognitive fluency design for the older adults through Nostalgia-based empowerment.","authors":"Yingjia Zhou, Xianhua Sun","doi":"10.1007/s40520-026-03396-2","DOIUrl":"https://doi.org/10.1007/s40520-026-03396-2","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and prescribing patterns of antiosteoporosis medicines in Chinese patients: a real-world retrospective study.","authors":"Shuo Zhang, Yuqing Fan, Mengyao Xue, Linfeng Jiang, Chen Mu, Nan Peng, Dongning Yao","doi":"10.1007/s40520-026-03382-8","DOIUrl":"https://doi.org/10.1007/s40520-026-03382-8","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-animal relationships in older persons: from pet companionship to animal-assisted interventions. A position statement.","authors":"Andrea Ungar, I Ambrosino, G Rivasi, L Ceolin, G Bellelli, E Bisconti, M C Catalani, A Cherubini, L Colombo, L Contalbrigo, A M Cotroneo, C Mariti, L Mechelli, M Melosi, A Morandi, F Mutinelli, C Mussi","doi":"10.1007/s40520-026-03386-4","DOIUrl":"https://doi.org/10.1007/s40520-026-03386-4","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic control in the context of frailty: a mortality risk assessment in older diabetic patients.","authors":"Hong-Jie Yu, Eric Tsz-Chun Lai, Ruby Yu, Jean Woo","doi":"10.1007/s40520-026-03385-5","DOIUrl":"https://doi.org/10.1007/s40520-026-03385-5","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From meta-analysis to knowledge graphs: reimagining social isolation research in older adults","authors":"Zian Shou,&nbsp;Yisheng Liang,&nbsp;Chang Lin,&nbsp;Yibo He","doi":"10.1007/s40520-026-03394-4","DOIUrl":"10.1007/s40520-026-03394-4","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03394-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of eight insulin resistance surrogate indices in predicting incident stroke among middle-aged and older individuals without diabetes: a nationwide prospective cohort study.","authors":"Jun Ran, Jinxi Wang, Xuemei Zhao, Qiong Zhou, Yan Huang, Mei Zhai, Xin Quan, Yuhui Zhang","doi":"10.1007/s40520-026-03376-6","DOIUrl":"https://doi.org/10.1007/s40520-026-03376-6","url":null,"abstract":"<p><strong>Background: </strong>Although insulin resistance (IR) surrogate indices have demonstrated associations with and predictive value for incident stroke, previous studies focused mainly on diabetic or general populations, with limited comprehensive comparisons in non-diabetic populations.</p><p><strong>Aims: </strong>To systematically compare eight IR surrogate indices for predicting incident stroke in middle-aged and older individuals without diabetes.</p><p><strong>Methods: </strong>Using data from the China Health and Retirement Longitudinal Study (CHARLS), we analyzed 6,377 non-diabetic participants aged ≥ 45 years followed from 2011 to 2020. Multivariate Cox proportional hazards regression models and restricted cubic spline (RCS) analyses were used to assess associations between IR surrogate indices and incident stroke. Harrell's C-index, time-dependent C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate and compare the predictive performance of different IR surrogate indices for incident stroke. Subgroup and sensitivity analyses were conducted to verify robustness.</p><p><strong>Results: </strong>Over 9 years of follow-up, 550 incident stroke events (8.6%) were recorded. All eight IR surrogate indices were significantly associated with incident stroke. Regarding predictive performance, the estimated glucose disposal rate (eGDR) model significantly outperformed the base model and other IR surrogate index models across multiple evaluation dimensions, including overall C-index (0.660, 95% CI: 0.638-0.681), time-dependent C-index, NRI, and IDI. Subgroup analyses and sensitivity analyses confirmed the robustness of the eGDR model's predictive advantages.</p><p><strong>Conclusions: </strong>eGDR outperformed other IR surrogate indices in predicting incident stroke among middle-aged and older individuals without diabetes, suggesting potential utility for early stroke risk assessment.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}