Aging Clinical and Experimental Research最新文献

{"title":"Blood transfusion in older surgical patients: the only option or is there a better approach?","authors":"Mariagiovanna Cozza,&nbsp;Virginia Boccardi,&nbsp;Ruslan Duka,&nbsp;Yogesh Vashist,&nbsp;Luigi Marano","doi":"10.1007/s40520-025-03033-4","DOIUrl":"10.1007/s40520-025-03033-4","url":null,"abstract":"<div><p>Anemia is a common clinical condition that can significantly affect patient outcomes, particularly in those undergoing surgery. In older adults, the presence of anemia combined with cardiovascular disease can increase surgical morbidity and mortality, influencing surgical decisions and creating a cascade of complications that may negatively impact recovery. Blood transfusion remains the primary response to anemia in the perioperative setting, despite evidence suggesting potential adverse effects on survival and recovery. However, older adults present unique challenges due to age-related physiological changes anda reduced tolerance to anemia and blood loss. The debate between restrictive and liberal blood transfusion strategies in this population remains unresolved. Patient Blood Management (PBM) protocols have been developed to systematically address perioperative anemia. This review emphasizes the need for a nuanced approach to transfusion in older adults, suggesting that while a restrictive strategy may not be universally applicable, decisions should be guided by thorough clinical evaluations. These assessments should prioritize not only hemoglobin levels but also patient-specific factors, including life expectancy, comorbidities, and patient preferences, with the involvement of a multidisciplinary team to tailor the best approach for everyone.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03033-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of different dual task mode interventions on cognitive function in older adults with mild cognitive impairment or dementia: a systematic review and network meta-analysis","authors":"Yuqing Hao,&nbsp;Yajie Zhao,&nbsp;Huanhuan Luo,&nbsp;Lanying Xie,&nbsp;Huixiu Hu,&nbsp;Chao Sun","doi":"10.1007/s40520-025-03016-5","DOIUrl":"10.1007/s40520-025-03016-5","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate and compare the effects of different dual task interventions on cognitive function in older adults with cognitive impairment or dementia.</p><h3>Methods</h3><p>We searched eight databases, including PubMed, Cochrane Library, and EMBASE, to obtain studies exclusively comprising randomized controlled trials on dual task interventions in individuals aged 60 and older with mild cognitive impairment or dementia, up to July 28, 2024. Study quality was evaluated using the Cochrane Risk of Bias Tool. Analyses included pairwise meta-analyses via Review Manager 5.4 and network meta-analyses via Stata 14.0.</p><h3>Results</h3><p>A total of 32 RCTs involving 2370 participants were included. Dual cognitive task training had the most significant impact on global cognition (SUCRA = 79.2%, mean rank = 1.6) and motor-cognitive dual task training was the only dual task intervention with a notable improvement in executive function (SMD = 1.53, 95% CI 0.06–3.01). For physical function, dual motor task training was most effective, improving gait performance (SMD = 0.34), muscle strength (SMD = 0.28), and balance (SMD = 0.90). Motor-cognitive dual task training demonstrated the greatest effectiveness in enhancing activities of daily living (SMD = 1.50) and quality of life (SMD = 1.20), while reducing depressive symptoms (SMD = − 0.96).</p><h3>Conclusions</h3><p>Dual cognitive task training is the most effective dual task intervention for enhancing global cognition. Motor-cognitive dual task training is the only dual task mode that significantly improves executive cognition.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03016-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of extreme weather events on food security among older people: a systematic review","authors":"Daniele Nucci,&nbsp;Flavia Pennisi,&nbsp;Antonio Pinto,&nbsp;Emanuele De Ponti,&nbsp;Giovanni Emanuele Ricciardi,&nbsp;Carlo Signorelli,&nbsp;Nicola Veronese,&nbsp;Alberto Castagna,&nbsp;Stefania Maggi,&nbsp;Chiara Cadeddu,&nbsp;Vincenza Gianfredi","doi":"10.1007/s40520-025-03050-3","DOIUrl":"10.1007/s40520-025-03050-3","url":null,"abstract":"<div><h3>Background</h3><p>Climate change has intensified the frequency and severity of extreme weather events, disproportionately affecting vulnerable populations, including older people for which the literature is still limited. This systematic review investigated the impact of extreme weather events on malnutrition and food security among individuals aged 60 and older.</p><h3>Methods</h3><p>A systematic search of PubMed/MEDLINE, Scopus, and Web of Science was conducted without restrictions (October 2024), and following PRISMA guidelines. Observational studies examining older adults exposed to extreme weather events (e.g., droughts, floods, heatwaves, hurricanes) and their effects on malnutrition or food security were included. The Newcastle-Ottawa Scale assessed study quality. Protocol was registered in PROSPERO (ID: CRD42024596910).</p><h3>Results</h3><p>From 1,709 articles, six observational studies involving 265,000 participants (aged 60 years and over) were included. These studies spanned multiple geographies, with a concentration in the United States. Findings revealed a dual impact: while some studies reported protective factors, such as social support and economic stability, others highlighted increased malnutrition risk due to disrupted food supply, economic hardship, and inadequate adaptive responses. Heterogeneity in study designs, exposure definitions, and outcome measures limited comparability.</p><h3>Conclusion</h3><p>Extreme weather events significantly impact malnutrition and food security among older adults, with outcomes influenced by socio-economic and geographical factors. Further longitudinal studies are needed to clarify causal pathways and inform targeted public health interventions to enhance resilience in aging populations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03050-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease","authors":"Shiyi Yang,&nbsp;Jiwei Jiang,&nbsp;Linlin Wang,&nbsp;Min Zhao,&nbsp;Wenyi Li,&nbsp;Yunyun Duan,&nbsp;Qiwei Ren,&nbsp;Tianlin Jiang,&nbsp;Shirui Jiang,&nbsp;Huiying Zhang,&nbsp;Yilong Wang,&nbsp;Weiqi Chen,&nbsp;Jun Xu","doi":"10.1007/s40520-025-03045-0","DOIUrl":"10.1007/s40520-025-03045-0","url":null,"abstract":"<div><h3>Background</h3><p>Gait disturbance is a prevalent characteristic of cerebral small vessel disease (CSVD), yet the underlying mechanisms remain largely unclear.</p><h3>Aimes</h3><p>To test the hypothesis that enlarged perivascular spaces in the basal ganglia (BG-EPVS) are related to gait performance in individuals with CSVD and the elderly.</p><h3>Methods</h3><p>This cross-sectional study included 138 CSVD patients and 62 healthy elderly controls who underwent quantitative gait analysis. Neuroimaging markers, including BG-EPVS, white matter hyperintensities (WMH), lacunes, and cerebral microbleeds (CMB), were assessed using MRI. Principal component analysis (PCA) was used to reduce the dimensionality of multiple gait indicators. Linear regression models were employed to examine the relationship between BG-EPVS and the principal component values of gait performance, with WMH as a potential mediator.</p><h3>Results</h3><p>Compared to healthy controls, CSVD patients exhibited significantly prolonged stance and double-support phases, shortened swing phase, reduced gait speed, increased step width, and decreased stride length and step height (<i>p</i> &lt; 0.05 for all comparisons). Higher BG-EPVS grades were independently associated with poorer gait performance in both CSVD patients (<i>p</i> = 0.012) and all subjects (<i>p</i> = 0.001), even after adjusting for other CSVD markers. WMH partially mediated the relationship between BG-EPVS and gait performance, accounting for 18.2% of the total effect in CSVD patients and 24.9% of the total effects in all subjects.</p><h3>Conclusion</h3><p>BG-EPVS is independently associated with gait disturbances in both CSVD patients and the elderly. These findings underscore the importance of early gait assessment in the aging population. Further longitudinal research is needed to confirm these associations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03045-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal association between chronic pain and frailty occurrence, and the modifiable role of a healthy lifestyle in Chinese middle-aged and older population: a community based, prospective cohort study","authors":"Chao Li,&nbsp;Na Zeng,&nbsp;Fu-Shan Xue","doi":"10.1007/s40520-025-03042-3","DOIUrl":"10.1007/s40520-025-03042-3","url":null,"abstract":"<div><h3>Background</h3><p>While western studies suggest a temporal association between chronic pain and frailty, as well as the impacts of healthy lifestyle interventions, these relationships remain underexplored in the Chinese population.</p><h3>Methods</h3><p>We conducted a longitudinal study with 13,601 participants from the China Health and Retirement Longitudinal Study, covering 2011–2018. Pain was assessed via self-report, and frailty was evaluated using a 29-item deficit-accumulation frailty index. Five lifestyle factors, such as physical activity, alcohol consumption, smoking, body mass index, and sleep duration, were assessed, and the participants were categorized into favorable, intermediate, and unfavorable lifestyle groups.</p><h3>Results</h3><p>During the 7-year follow-up, 3,356 cases of frailty were discerned. Participants who reported pain at baseline assessment had a higher risk of developing frailty compared to those without pain (hazard ratio [HR] = 1.10; 95%confidence interval [CI], 1.03–1.19). This association was particularly evident in middle-aged individuals (HR = 1.13; 95% CI, 1.01–1.26). <i>P</i>articipants with severe pain at baseline assessment had a 1.16-fold higher risk of frailty (95%CI, 1.05–1.28, <i>P</i>_trend= 0.0067). Among the participants with mild or moderate pain at baseline assessment, the risk of developing frailty was significantly reduced by a favorable lifestyle (HR = 0.62; 95% CI, 0.51–0.76) or intermediate lifestyle (HR = 0.83; 95% CI, 0.70–0.98). Additionally, a favorable lifestyle was significantly associated with a decreased risk of developing frailty in the participants with severe pain at baseline assessment (HR = 0.75; 95%CI, 0.59–0.96). Mediation analysis indicated that a healthy lifestyle could mitigate 2.97% of frailty risk associated with chronic pain.</p><h3>Conclusions</h3><p>Chronic pain is strongly associated with an increased risk of developing frailty in Chinese older population, but the implementation of healthy lifestyles can significantly reduce this risk.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03042-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effect between telomere length and thirteen types of cancer in Asian population: a bidirectional Mendelian randomization study","authors":"Bowen Yang,&nbsp;Junming Bi,&nbsp;Weinan Zeng,&nbsp;Mingquan Chen,&nbsp;Zhihao Yao,&nbsp;Shouyu Cheng,&nbsp;Zhaoqiang Jiang,&nbsp;Changzheng Zhang,&nbsp;Hangyu Liao,&nbsp;Xiaokang Gu,&nbsp;Zhiyong Xian,&nbsp;Yuming Yu","doi":"10.1007/s40520-025-03046-z","DOIUrl":"10.1007/s40520-025-03046-z","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between leukocyte telomere length (LTL) and the risk of developing various cancers has always been controversial and predominantly focused on European populations. Hence, Mendelian randomization (MR) was applied to the Asian population to explore the causal relationships between LTL and the risk of developing various cancers.</p><h3>Methods</h3><p>We explored the causal connection between LTL and the risk of developing thirteen types of cancer in Asian populations using freely available genetic variation data. The primary analytical method employed was the inverse variance weighted (IVW) method, complemented by sensitivity and validation analyses. Following Bonferroni correction, <i>P</i> &lt; 0.0038 was considered to indicate statistical significance, and P values ranging from 0.0038 to 0.05 were considered to indicate a nominally significant association.</p><h3>Results</h3><p>The findings indicated significant positive associations between LTL and the risk of developing lung cancer [odds ratio (OR) = 1.6009, 95% confidence interval (CI) 1.3056–1.9629, <i>P</i> = 6.08 × 10⁻⁶] and prostate cancer (OR = 1.4200, 95% CI 1.1489–1.7550, <i>P</i> = 0.0012). Additionally, there was a nominally significant association between LTL and the risk of developing hematological malignancy (OR = 1.5119, 95% CI 1.0810–2.1146, <i>P</i> = 0.0157). No statistically significant relationships between LTL and the risk of developing the other ten kinds of cancer were detected. No causal link between the risk of developing various cancers and LTL was discovered.</p><h3>Conclusions</h3><p>Asians with longer telomeres are more prone to developing lung and prostate cancer. There is also a nominally significant association between longer telomeres and the risk of developing hematological malignancy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03046-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow gait speed is associated with frailty, activities of daily living and nutritional status in in-patient pulmonology patients","authors":"Asli Gorek Dilektasli,&nbsp;Nilüfer Aylin Acet Öztürk,&nbsp;Demet Kerimoğlu,&nbsp;Ayten Odabaş,&nbsp;Mine Tül Yaman,&nbsp;Abdurrahman Dogan,&nbsp;Ezgi Demirdogen,&nbsp;Ozge Aydın Guclu,&nbsp;Funda Coşkun,&nbsp;Ahmet Ursavas,&nbsp;Mehmet Karadağ","doi":"10.1007/s40520-025-03040-5","DOIUrl":"10.1007/s40520-025-03040-5","url":null,"abstract":"<div><h3>Background and aim</h3><p>The 4-meter gait speed (4MGS), a functional performance test, is increasingly used to predict health outcomes. This study investigated 4MGS, nutritional status, frailty, and daily living activities in tertiary care pulmonary diseases ward patients.</p><h3>Methods</h3><p>Patients were assessed for nutritional status, activities of daily living, and frailty using the Mini Nutritional Assessment (MNA) Test, Barthel Questionnaire, and FRAIL scale. Those with 4MGS &lt; 1 m/sec were classified as having slow gait speed.</p><h3>Results</h3><p>80 patients (F/M: 21/59, mean age 58 ± 19) were included. Diagnoses included pneumonia, chronic obstructive pulmonary disease, pleural effusion, and interstitial lung disease. Patients had a 4MGS of 0,74 ± 0,24 m/sn, MNA score of 14.0 [IQR 25–75:11.0–19.8] points, Barthel index of 95 [IQR 25–75:70–100] points, FRAIL scale of 3 [IQR 25–75:1.0–4.0], and a hand-grip strength of 18.8 [IQR 25–75:15.7–25.9] kg. Slow gait speed patients had lower MNA, FRAIL scores, and handgrip strength. Multivariable regression analysis showed that slower gait speed was associated with lower serum protein level (B = 0.013, SE = 0.005, 95% CI: 0.004 to 0.022, <i>p</i> = 0.004), lower hand grip strength (B = -0.002, SE = 0.001, 95% CI: -0.003 to -0.00006, <i>p</i> = 0.041) and malnutrition risk (B = 0.024, SE = 0.007, 95% CI: 0.011 to 0.038, <i>p</i> &lt; 0.001).</p><h3>Discussion and conclusion</h3><p>4MGS correlates with comorbidities, frailty, grip strength, and nutritional status in hospitalized pulmonary patients. Slow gait patients are more malnourished despite similar age, sex, BMI, and comorbidities.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03040-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary quality and biological aging: two-mediation analysis","authors":"Li-Sha Zeng,&nbsp;Yi-Ting Wu,&nbsp;Feng-Ping Zhang","doi":"10.1007/s40520-025-03038-z","DOIUrl":"10.1007/s40520-025-03038-z","url":null,"abstract":"<div><h3>Aims</h3><p>Previous research has emphasized the firm link between diet and human health. However, the connection between comprehensive dietary patterns and biological aging has not been fully investigated. Our aim was to explore the potential association between dietary quality and delaying aging.</p><h3>Methods</h3><p>A total of 20,763 participants from the National Health and Nutrition Examination Survey were included in this cross-sectional study. The Mediterranean diet score (MDS), dietary approaches to stop hypertension index (DASHI), and healthy eating index 2020 (HEI2020) were utilized to assess dietary quality. Biological age was determined using the Klemera-Doubal method (KDM) biological age and phenotypic age (Levine’s), with the difference between biological age and chronological age representing aging acceleration. Independent relationships between dietary quality and biological aging were analyzed using weighted adjusted linear and logistic regression. Nonlinear trends and robustness of conclusions were examined. A secondary objective was to examine the role of Klotho and γ-glutamyltransferase (GGT) in mediation analyses.</p><h3>Results</h3><p>Dietary quality exhibited a negative association with biological aging, as evidenced by the interplay between three dietary patterns and two aging measures (The β of the linear regressions were all &lt; 0). Restricted cubic splines confirmed the linear relationship, while subgroup interactions bolstered the stability of the results. Mediation analysis indicated that klotho and GGT partially mediated the association between dietary quality and biological aging (combined proportion mediation: 4.1-8.0%).</p><h3>Conclusion</h3><p>Dietary quality is closely associated with biological aging, with anti-aging proteins and oxidative stress potentially serving as underlying mediation mechanisms.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03038-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a text message + pedometer intervention to increase steps after emergency department discharge: a pilot study","authors":"Brian Suffoletto,&nbsp;Waverly Mayer,&nbsp;Caitlin Toth,&nbsp;Nick Ashenburg,&nbsp;Michelle Lin,&nbsp;Michael Losak,&nbsp;David Kim","doi":"10.1007/s40520-025-03030-7","DOIUrl":"10.1007/s40520-025-03030-7","url":null,"abstract":"<div><h3>Background</h3><p>Older adults face increased risk of functional impairments after Emergency Department (ED) discharge, yet no evidence-based interventions exist for this population.</p><h3>Objective</h3><p>To evaluate the feasibility, safety, and effectiveness of Safe Steps, a text message + pedometer intervention designed to motivate individuals to meet step count goals.</p><h3>Methods</h3><p>We recruited ED patients aged ≥ 60 with low physical activity. Participants received a pedometer in the ED, daily text messages to report steps, and weekly prompts to set step goals over 4 weeks. We assessed step count reporting rates, falls, and change in steps over time.</p><h3>Results</h3><p>Among analyzed participants (<i>n</i> = 40), daily step reporting was high (95% of weeks with 2 + readings). No participants had falls due to the intervention. Step count increased by a mean of 359 steps per week (95% confidence interval 182–536).</p><h3>Conclusion</h3><p>Safe Steps appears feasible, safe, and may be effective for promoting activity after ED discharge.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03030-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study","authors":"Jili Liu,&nbsp;Xin Xia,&nbsp;Zhaolin Wang,&nbsp;Yanqin Wang,&nbsp;Gang Qin","doi":"10.1007/s40520-025-03012-9","DOIUrl":"10.1007/s40520-025-03012-9","url":null,"abstract":"<div><h3>Background</h3><p>Musculoskeletal disease, which has a complicated relationship with frailty, is a common clinical problem among elderly individuals.</p><h3>Aims</h3><p>This study evaluated the potential causal relationships between osteosarcopenia, osteoarthritis and frailty by Mendelian Randomization (MR) analysis.</p><h3>Methods</h3><p>This study employed a two-sample MR approach to investigate the causal relationships among osteosarcopenia, osteoarthritis and frailty. Published summary statistics were used to obtain instrumental variables at the genome-wide significance level.</p><h3>Results</h3><p>Among the age groups with osteoporosis, high total bone mineral density (TBMD) (45—60, OR = 0.966, 95% CI 0.940–0.993, <i>P</i> = 0.013) and TBMD (over 60, OR = 0.974, 95% CI 0.954–0.994, <i>P</i> = 0.011) reduced the risk of frailty. Similarly, high forearm BMD (FA-BMD), high ultradistal forearm BMD (UFA-BMD), and high Heel-BMD at different sites also reduced the risk of frailty (OR = 0.966, 95% CI 0.936–0.996, <i>P</i> = 0.028; OR = 0.975, 95% CI 0.953–0.997, <i>P</i> = 0.029; OR = 0.981, 95% CI 0.967–0.995, <i>P</i> = 0.008). Among the characteristics related to sarcopenia, grip strength in the left hand, grip strength in the right hand, appendicular lean mass, and walking pace were all protective factors for frailty (OR = 0.788, 95% CI 0.721–0.862, <i>P</i> &lt; 0.001; OR = 0.800, 95% CI 0.737–0.869, <i>P</i> &lt; 0.001; OR = 0.955, 95% CI 0.937–0.974, <i>P</i> = 0.000; OR = 0.480, 95% CI 0.388–0.593, <i>P</i> &lt; 0.001), with low grip strength in those over 60 years of age significantly positively correlated with frailty (OR = 1.168, 95% CI 1.059–1.289, <i>P</i> = 0.002). The MR results of osteoarthritis and frailty revealed a causal relationship between specific joint sites and frailty, including KOA (OR = 1.086, 95% CI 1.017–1.160, <i>P</i> = 0.014), HOA (OR = 1.028, 95% CI 1.007–1.049, <i>P</i> = 0.009), and KOA/HOA (OR = 1.082, 95% CI 1.053–1.113, <i>P</i> = 0.000), increasing the risk of frailty.</p><h3>Conclusion</h3><p>Osteosarcopenia, osteoarthritis and frailty exhibit significant causal effects, rendering them risk factors for frailty. Therefore, in clinical practice, patients with osteosarcopenia and osteoarthritis should be required to undergo relevant interventions to reduce the risk of frailty.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03012-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}