Aging Clinical and Experimental Research最新文献

{"title":"Neurobiological effects of music-making interventions for older adults: a systematic review","authors":"Nicole Espinosa,&nbsp;Zoe Menczel Schrire,&nbsp;Andrew C. McKinnon,&nbsp;Hannes Almgren,&nbsp;Loren Mowszowski,&nbsp;Sharon L. Naismith","doi":"10.1007/s40520-025-03006-7","DOIUrl":"10.1007/s40520-025-03006-7","url":null,"abstract":"<div><h3>Background</h3><p>Evidence on the impact of music-making interventions on brain plasticity in older adults is limited.</p><h3>Aims</h3><p>To investigate whether music-making interventions in older adults induce neurobiological changes and if such changes relate to cognitive improvements.</p><h3>Methods</h3><p>A systematic search was conducted in Medline, PsycINFO, and Scopus. Inclusion criteria targeted randomised controlled trials with older adults (with and without mild cognitive impairment [MCI]), music-making interventions as exposure, and neurobiological measures as the primary outcome.</p><h3>Results</h3><p>Six studies (555 cognitively intact older adults) met inclusion criteria—five used piano training, one used choral singing. Three studies had overlapping cohorts, and four had a high risk of bias. One study employed electroencephalography (EEG) to measure frontal and parietal activity, while five used structural MRI to assess cortical, subcortical, and white matter integrity. Methodological heterogeneity limited comparability. Findings in the piano group included increased frontal theta power during an improvisation task, greater grey matter volume in the dorsolateral prefrontal cortex and cerebellum, slower fibre density decline in the fornix and preserved grey matter volume in the right auditory cortex and hippocampus. Only one study reported a positive correlation between neurobiological changes and executive functioning improvements. No studies assessed neurobiological outcomes in MCI.</p><h3>Discussion</h3><p>Evidence on music-making interventions and neuroplasticity in older adults remains inconclusive due to limited studies, high risk of bias, and methodological variability. While preliminary findings suggest potential neurobiological changes with music-making interventions, there is insufficient evidence to draw firm conclusions.</p><h3>Conclusions</h3><p>High-quality trials are needed to clarify the neurobiological impact of music-making, particularly in MCI populations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03006-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength as a predictor of one-year mortality in elderly patients with fragility hip fracture","authors":"Francesco Salis,&nbsp;Irene Buffoli,&nbsp;Maristella Belfiori,&nbsp;Alice Bellisai,&nbsp;Benedetta Gianoglio,&nbsp;Giuseppe Marongiu,&nbsp;Monia Marzuolo,&nbsp;Giuseppe Navarra,&nbsp;Veronica Piras,&nbsp;Benedetta Puxeddu,&nbsp;Luisa Sanna,&nbsp;Chiara Scudu,&nbsp;Antonio Capone,&nbsp;Antonella Mandas","doi":"10.1007/s40520-025-03019-2","DOIUrl":"10.1007/s40520-025-03019-2","url":null,"abstract":"<div><h3>Background</h3><p>Fragility fractures occur on porotic bones due to minor trauma and are associated with high rates of disability and mortality.</p><h3>Aims</h3><p>To evaluate the ability of handgrip strength to predict one-year mortality in elderly patients with fragility hip fracture.</p><h3>Methods</h3><p>We enrolled patients aged 65 years and older with fragility hip fractures admitted to an Italian orthopedic unit. They underwent a comprehensive geriatric assessment, including handgrip strength measurement, and all received surgical intervention.</p><h3>Results</h3><p>Among the 322 enrolled patients (median age: 84 years; 75.2% women), the one-year mortality rate was 15.5%. According to the European Working Group on Sarcopenia in Older People 2 guidelines, 235 subjects (73.0%) exhibited low handgrip strength. This group revealed HR: 2.36 (95%CI: 1.06–5.24) for one-year mortality compared to the group with adequate handgrip strength (<i>p</i> = 0.036). After adjusting for age and risk of adverse event, through Multidimensional Prognostic Index, the HR decreased to 1.31 (95%CI: 0.56–3.07), with a lower validity.</p><h3>Discussion</h3><p>Our study found a slightly lower one-year mortality than other studies with similar samples, probably due to the co-management of orthopedic and geriatric teams. As for the main outcome, low handgrip strength was significantly associated with one-year mortality. However, the significance diminished when considering possible confounding variables, despite a lower precision of the model.</p><h3>Conclusions</h3><p>Low handgrip strength predicts one-year mortality in elderly people with fragility hip fractures. Further studies are needed to explore the possible influence of confounders.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03019-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with mild cognitive impairment and dementia amongst the oldest old: findings based on the nationally representative “old age in Germany (D80+)” study","authors":"André Hajek,&nbsp;Razak M. Gyasi,&nbsp;Liang-Kung Chen,&nbsp;Karl Peltzer,&nbsp;Hans-Helmut König","doi":"10.1007/s40520-025-03022-7","DOIUrl":"10.1007/s40520-025-03022-7","url":null,"abstract":"<div><h3>Background/Aims</h3><p>Particularly among the oldest old, there is restricted knowledge regarding the factors associated with mild cognitive impairment and dementia using data from large, nationally representative samples. Thus, our aim was to address this knowledge gap.</p><h3>Methods/Design</h3><p>We used data from the nationally representative “Old Age in Germany (D80+)” study covering community-dwelling and institutionalized individuals in the entire country (<i>n</i> = 2,555). Mean age was 85.5 years (SD: 4.2), ranging from 80 to 100 years (61.7% of the participants were female). The DemTect was used to measure cognitive impairment in terms of probable mild cognitive impairment and probable dementia. Sociodemographic, lifestyle-related, psychosocial and health-related independent variables were included in the multinomial regression analysis.</p><h3>Results</h3><p>In the analytic sample, 57.8% of the individuals did not have cognitive impairment, 24.2% of the individuals had mild cognitive impairment and 18.0% had probable dementia. Regression analysis identified some sociodemographic (e.g., advanced age, being male, lower education), lifestyle-related (lower cognitive activities), psychosocial (higher loneliness and absence of meaning in life), as well as health-related (e.g., functional impairment) factors associated with probable MCI and probable dementia. Loneliness was only associated with these outcomes among women, but not men.</p><h3>Discussions</h3><p>Based on large, nationally representative data, this study revealed several factors associated with probable MCI and dementia – which enhances our current understanding mainly based on small or selective samples.</p><h3>Conclusion</h3><p>Such knowledge may help to address those at risk for cognitive impairment. Longitudinal studies are required to gain further insights.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03022-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship among socioeconomic status, social support and frailty: is there a gender difference?","authors":"Ping Dong,&nbsp;Xian-qi Zhang,&nbsp;Wen-qiang Yin,&nbsp;Zi-yuan Li,&nbsp;Xiao-na Li,&nbsp;Min Gao,&nbsp;Yong-li Shi,&nbsp;Hong-wei Guo,&nbsp;Zhong-ming Chen","doi":"10.1007/s40520-025-03013-8","DOIUrl":"10.1007/s40520-025-03013-8","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to determine the relationship among socioeconomic status, social support and frailty, and its gender difference.</p><h3>Methods</h3><p>Education and income were combined to indicate the socioeconomic status. The Social Support Rating Scale (SSRS) was used to measure the level of social support. Frailty was measured by the FRAIL Scale. Mediation effects were analyzed using the PROCESS 4.1 macro in SPSS version 26.0.</p><h3>Results</h3><p>Among the 936 participants, socioeconomic status had a direct effect on frailty (effect = − 0.088, 95% <i>CI</i>: − 0.142, − 0.021). Social support was an indirect pathway for the relationship between socioeconomic status and frailty (effect = − 0.011, 95% <i>CI</i>: − 0.023, − 0.003), accounting for 11.11% of the total effect. Stratified by gender, we found that the total, direct and indirect effects of socioeconomic status on frailty were significant only in the female subsample.</p><h3>Conclusion</h3><p>Overall, there was a significant association between socioeconomic status and frailty among the rural older adults, and social support mediated this relationship. However, there were gender differences in the association among socioeconomic status, social support and frailty. Specifically, the correlation between socioeconomic status and frailty and the mediating role of social support were found only in the female subsample. The public health sector should focus on the rural older adults with low socioeconomic status and lack of social support, taking targeted interventions to avoid and delay the occurrence and progress of frailty.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03013-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does a high body mass index remain a protective factor in hip fracture patients with hypertension and diabetes?","authors":"Zhening Guo,&nbsp;Weicheng Wu,&nbsp;Bo Lv,&nbsp;Yongtao Mao,&nbsp;Chang She,&nbsp;Wei Xu,&nbsp;Jun Gu,&nbsp;Liubing Li,&nbsp;Jie Pan","doi":"10.1007/s40520-025-03010-x","DOIUrl":"10.1007/s40520-025-03010-x","url":null,"abstract":"<div><h3>Background</h3><p>Body mass index (BMI) was used to classify overweight or obesity. The obesity paradox was observed in elderly hip fracture patients. However, obesity has been implicated as one of the major risk factors for hypertension and diabetes. This study aims to determine whether a high body mass index (BMI) remains a protective factor in hip fracture patients with comorbid hypertension or diabetes, and to identify the optimal BMI threshold that best supports motor function recovery.</p><h3>Methods</h3><p>This study included patients aged 65 years and older who have underwent hip fracture surgery. Harris Hip Score (HHS) was utilized to evaluate the functional recovery, the relationship between BMI and HHS was examined using both linear and generalized additive model (GAM). A threshold model was established with BMI of 24 kg/m² and the difference between the threshold model and the GAM was compared utilizing the likelihood ratio test (LRT).</p><h3>Results</h3><p>A total of 213 patients were enrolled in the study. A nonlinear relationship was identified between BMI and HHS in patients with either hypertension or diabetes and the HHS demonstrated a significant downward trend with increasing BMI. The LRT revealed no significant difference between the threshold effect model with a BMI value of 24 kg/m² and the GAM.</p><h3>Conclusions</h3><p>This study reveals that the protective effect of high BMI on postoperative motor function in hip fracture patients is significantly modulated by comorbidities. We recommend modulating the BMI to approximately 24 kg/m² for elderly patients with hip fractures and comorbid conditions such as hypertension and diabetes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03010-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further insights into influence factors of hypertension in older patients with obstructive sleep apnea syndrome: a model based on multiple centers","authors":"Libo Zhao,&nbsp;Xin Xue,&nbsp;Yinghui Gao,&nbsp;Weihao Xu,&nbsp;Zhe Zhao,&nbsp;Weimeng Cai,&nbsp;Dong Rui,&nbsp;Xiaoshun Qian,&nbsp;Lin Liu,&nbsp;Li Fan","doi":"10.1007/s40520-025-02986-w","DOIUrl":"10.1007/s40520-025-02986-w","url":null,"abstract":"<div><h3>Objective</h3><p>To construct a novel model or a scoring system to predict hypertension comorbidity in older patients with obstructive sleep apnea syndrome (OSAS).</p><h3>Methods</h3><p>A total of 1290 older patients with OSAS from six tertiary hospitals in China were enrolled. The sample was randomly divided into a modeling set (80%) and validation set (20%) using a bootstrap method. Binary logistic regression analysis was used to identify influencing factors. According to the regression coefficients, a vivid nomogram was drawn, and an intuitive score was determined. The model and score were evaluated for discrimination and calibration. The <i>Z</i>-test was utilized to compare the predictive ability between the model and scoring system.</p><h3>Results</h3><p>In the multivariate analysis, age, body mass index (BMI), apnea–hypopnea index (AHI), total bilirubin (TB), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG) were significant predictors of hypertension. The area under the receiver operating characteristic curve of the model in the modeling and validation sets was 0.714 and 0.662, respectively. The scoring system had predictive ability equivalent to that of the model. Moreover, the calibration curve showed that the risk predicted by the model and the score was in good agreement with the actual hypertension risk.</p><h3>Conclusions</h3><p>This accessible and practical correlation model and diagram can reliably identify older patients with OSAS at high risk of developing hypertension and facilitate solutions on modifying this risk most effectively.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02986-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study","authors":"Chunhua Liang,&nbsp;Xueqin Yan,&nbsp;Jing Tian,&nbsp;Yunzhu Yang,&nbsp;Xiaohua Xiao,&nbsp;Yaohui Huang,&nbsp;Tianfu Wang","doi":"10.1007/s40520-025-03001-y","DOIUrl":"10.1007/s40520-025-03001-y","url":null,"abstract":"<div><h3>Background</h3><p>Although blood-based biomarkers can be used to detect early Alzheimer’s disease (AD), population differences affect their clinical value in early diagnosis of the disease spectrum.</p><h3>Aims</h3><p>To examine the potential of plasma biomarkers to detect different stages along the AD continuum in a Chinese population.</p><h3>Methods</h3><p>We enrolled 113 adults from the Shenzhen community (53 cognitively unimpaired [CU], 45 with mild cognitive impairment [MCI], and 15 with AD). We used the single-molecule array technique to detect the levels of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated-tau181 (p-tau181), and performed <i>APOE</i> genotyping. We assessed the association between plasma biomarkers and cognitive scores, and used receiver operating characteristic curves to measure performance for early AD diagnosis.</p><h3>Results</h3><p>The plasma GFAP, NfL, and p-tau181 levels increased significantly in AD and were slightly higher in MCI than in CU (GFAP <i>p</i> = 0.811, NfL <i>p</i> = 0.909, p-tau181 <i>p</i> = 0.696). The plasma GFAP and p-tau181 levels negatively correlated with cognitive scores. Blood markers demonstrated higher performance in identifying AD than CU or MCI. Plasma p-tau181 displayed the highest diagnostic value for AD. Predictions of cognitive impairment were more robust when blood markers were combined with clinical indicators for AD (age, sex, body mass index, years of education, and <i>APOE ε4</i> carrier status).</p><h3>Discussion</h3><p>The expression of plasma GFAP, NfL, and p-tau181 increased in the AD continuum. Importantly, plasma p-tau181 could identify individuals with AD from the general population, with superior predictive performance when combined with age or sex.</p><h3>Conclusions</h3><p>Plasma biomarkers are useful screening indicators for early AD in Chinese adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03001-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and gender differences in health characteristics of older people with visual impairment","authors":"Salvatore Metanmo,&nbsp;Charnel Mbianda,&nbsp;Marie-Josiane Ntsama-Ebode,&nbsp;Callixte Kuate-Tegueu,&nbsp;Melanie Annick Magnerou,&nbsp;Nadine Simo,&nbsp;Antoine Gbessemehlan,&nbsp;Maturin Tabue-Teguo","doi":"10.1007/s40520-025-02998-6","DOIUrl":"10.1007/s40520-025-02998-6","url":null,"abstract":"<div><h3>Background</h3><p>Africa’s population is ageing, with an attendant increase in the number and duration of health problems such as visual impairment (VI). Few data are available from sub-Saharan Africa concerning age and gender differences in this population of people suffering from VI. The aim of this study was to examine age and gender differences in the health characteristics of older people with VI in Cameroon.</p><h3>Methods</h3><p>This was a cross-sectional study carried out in Douala, Cameroon, among people aged 55 and over. Participants had to be free of blindness, neurological disorders or other severe health problems. Sociodemographic and clinical variables were collected, including VI. We investigated differences between men and women in different age strata (&lt; 65, 65–75, &gt; 75 years) among people with VI.</p><h3>Results</h3><p>Among 403 participants, 356 (88.3%) had VI and, regardless of age group, there were significantly more women, who lived alone, were professionally active, overweight, had frailty syndrome and were less likely to drive a car. For other variables (education, chronic alcoholism, cognitive impairment, basic and instrumental activities of daily living, depression and falls), differences between men and women were only significant in certain age groups, with women generally at higher risk.</p><h3>Conclusion</h3><p>The prevalence of VI is high older (&gt; 55 years) adults in Cameroon, with clear differences between men and women. The oldest individuals, and women appear to be most vulnerable. The identification of at-risk groups/persons through this cross-sectional study should make it possible to adapt public health strategies to contribute to the WHO objective of healthy ageing.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02998-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia-related traits and risk of falls in older adults: results from meta-analysis of cohort studies and Mendelian randomization analyses","authors":"Haohan Yang,&nbsp;Yu Jiang,&nbsp;Dingfa Liang,&nbsp;Chang Yang,&nbsp;Kaihua Qin,&nbsp;Yong Xie,&nbsp;Licheng Zhang,&nbsp;Peifu Tang,&nbsp;Xiang Cui,&nbsp;Houchen Lyu","doi":"10.1007/s40520-025-02997-7","DOIUrl":"10.1007/s40520-025-02997-7","url":null,"abstract":"<div><h3>Background</h3><p>Observational studies examining sarcopenia-related traits and fall risk remain controversial. Herein, we conducted meta-analyses of cohort studies triangulated with Mendelian randomization (MR) analyses to examine the potential causality between sarcopenia-related traits and risk of falls in older adults.</p><h3>Methods</h3><p>Literature search across PubMed, Embase, and Cochrane Library was performed from inception to February 2023 to identify cohort studies examining sarcopenia-related traits (including hand strength, appendicular lean mass, and walking speed) and falls. We assessed the association between these traits and fall risk using random-effects models to calculate pooled odds ratios (OR) and 95% confidence intervals (CIs). MR analyses were conducted using summary statistics derived from the UK Biobank consortium for sarcopenia-related traits and FinnGen consortium for falls. The inverse-variance weighted method was used as primary analysis.</p><h3>Results</h3><p>Our meta-analysis included 34 cohort studies. The combined analysis of sarcopenia-related traits revealed a 33% reduced fall risk with each unit increase in walking speed (OR 0.67, 95% CI 0.54–0.84) and a 2% decrease with each unit increase in hand strength (OR 0.98, 95% CI 0.97–0.99). However, appendicular lean mass had no significant effect on falls. In the MR analyses, only walking speed was causally associated with falls (OR 0.64, 95% CI 0.48–0.84). Hand strength and appendicular lean mass showed no statistically significant causal effect on falls.</p><h3>Conclusion</h3><p>Evidence from meta-analysis and MR suggests a strong association between walking speed and fall risk in older adults. However, the relationship between hand strength, appendicular lean mass, and falls has not yet been established.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02997-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable sarcopenia and depressive symptoms in community-dwelling older adults: exploring the role of frailty and comorbidities","authors":"Emanuele Rocco Villani,&nbsp;Andrea Salerno,&nbsp;Federico Triolo,&nbsp;Laura Franza,&nbsp;Giulia Vaccari,&nbsp;Barbara Manni,&nbsp;Antonella Rita Vaccina,&nbsp;Lucia Bergamini,&nbsp;Vanda Menon,&nbsp;Davide Zaccherini,&nbsp;Andrea Fabbo","doi":"10.1007/s40520-025-03005-8","DOIUrl":"10.1007/s40520-025-03005-8","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia is a syndrome characterized by the loss of skeletal muscle associated with reduced physical strength/performance and could be correlated with depression, that is the most frequent cause of emotional distress in old age and can reduce the quality of life of the older adults.</p><h3>Aim</h3><p>The aim of the present study is to evaluate the association between probable sarcopenia and depressive symptoms in older adults, and the impact of comorbidity and frailty on this association.</p><h3>Methods</h3><p>This cross-sectional study included community-dwelling older adults at their first geriatric evaluation. Probable sarcopenia was screened according to SARC-F. Clinically significant depressive symptoms (CSDS) were assessed according to the 5-items geriatric depression scale (GDS.) Frailty was determined through the CHSA-clinical frailty scale (CFS). Comorbidity burden was scored through the Cumulative Illness Rating Scale-Geriatric (CIRS-CI).</p><h3>Results</h3><p>We included 238 participants with a mean age of 82.4 (± 6.9) years of age, 152 (63.6%) participants were females. Probable sarcopenia was diagnosed in 131 (55.0%) participants, while CSDS were present in 186 (78.2%) participants. In the multiadjusted model, probable sarcopenia was associated with a higher likelihood of CSDS (OR 2.70, 95% CI 1.03–6.12). No significant interaction of frailty and CIRS were found on the association between probable sarcopenia and CSDS.</p><h3>Conclusions</h3><p>Sarcopenia and depressive symptomatology are highly co-occurring in geriatric patients, and this association may be independent of frailty and comordibity burden.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03005-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}