Aging Clinical and Experimental Research最新文献

{"title":"Prevalence and characteristics of older adults with type 2 diabetes mellitus living in French Caribbean nursing homes: results from the baseline KASEHPAD study","authors":"Maturin Tabué-Teguo,&nbsp;Nadine Simo,&nbsp;Christine Rambhojan,&nbsp;Laurys Letchimy,&nbsp;Michel Bonnet,&nbsp;Fritz-Line Vélayoudom,&nbsp;Denis Boucaud-Maitre","doi":"10.1007/s40520-025-03008-5","DOIUrl":"10.1007/s40520-025-03008-5","url":null,"abstract":"<div><h3>Background</h3><p>The management of older adults with type 2 diabetes mellitus (T2DM) has not been previously assessed in nursing homes within the Caribbean region.</p><h3>Aims</h3><p>To investigate the prevalence of T2DM among residents of French Caribbean nursing homes and to characterize their health and functional status.</p><h3>Methods</h3><p>This cross-sectional study is based on baseline screening data from the KASEHPAD (Karukera Study of Ageing in Nursing Homes) cohort. Clinical characteristics and standard geriatric parameters were systematically collected and analyzed. Hemoglobin A1c (HbA1c) levels of older adults with diabetes were retrospectively extracted from patient records.</p><h3>Results</h3><p>A total of 332 participants aged 60 years or older were recruited from six nursing homes between September 2020 and November 2022. The prevalence of T2DM among residents was 28.3% (95% CI: 23.5–33.2). Among older adults with T2DM, 85.1% had hypertension, 17.1% had heart failure, and 24.1% had a history of stroke. The mean HbA1c level was 7.32 ± 1.5%. Of the 35 individuals (42.7%) with HbA1c &lt; 7%, 19 (54.3%) were receiving antidiabetic medications. Multivariate analysis identified HbA1c as the sole factor significantly associated with antidiabetic medication use (OR: 1.76, 95% CI: 1.12–3.04).</p><h3>Discussion</h3><p>Older adults with T2DM residing in French Caribbean nursing homes exhibit a high prevalence of cardiovascular risk factors and are at risk of overtreatment. The management of T2DM in this population appears to be driven primarily by blood glucose levels.</p><h3>Conclusion</h3><p>As the prevalence of older adults with T2DM is expected to rise in the Caribbean region, this trend will present significant challenges in delivering tailored care within future nursing home settings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03008-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant intervention to possibly delay disease progression and frailty in elderly idiopathic pulmonary fibrosis patients: a clinical trial","authors":"Hongyan Ren,&nbsp;Zheng Wang,&nbsp;Yafen Jiang,&nbsp;Qing Mu,&nbsp;Yaxin Li,&nbsp;Jing Wang,&nbsp;Tiantian Cui,&nbsp;Qijie Sun,&nbsp;Xiaojv Zhang","doi":"10.1007/s40520-025-03009-4","DOIUrl":"10.1007/s40520-025-03009-4","url":null,"abstract":"<div><h3>Background</h3><p>Idiopathic pulmonary fibrosis (IPF) is more likely to occur in the elderly population, and these patients often become depressed. It has been recognized that psychological disorders are not conducive to the control of many diseases. Thus, this study aims to determine whether alleviating depression can delay the progression of IPF and frailty in elderly patients with IPF.</p><h3>Methods</h3><p>IPF patients over 60 years old were included in the study. None had a prior history of psychological disorders. All developed depression after being diagnosed with IPF. During the 12-month follow-up, some patients received anti-depression interventions and the rest didn’t. Depression, IPF, frailty and peripheral inflammation at baseline and after follow-up were evaluated by indicators and scales such as BDI-II, FVC %pred, 6MWT, mMRC, CFS, TFI, SGRQ, K-BILD, IL-6, and TNF-α. Multivariate logistic regression was employed for data analysis.</p><h3>Results</h3><p>There were 213 elderly patients with IPF. Among the 89 patients who received anti-depression interventions, the above-mentioned indicators and scales did not deteriorate during the follow-up period (P &gt; 0.05). Among the remaining 124 patients, the FVC %pred, and 6MWT levels decreased, and the mMRC grade, CFS, TFI, SGRQ and K-BILD scores, and peripheral IL-6 and TNF-α levels increased during the follow-up period (P &lt; 0.05).</p><h3>Discussion</h3><p>Compared with non-intervened IPF patients, those receiving anti-depression interventions seemed to maintain a certain stability in IPF, frailty, and peripheral inflammation over a period.</p><h3>Conclusion</h3><p>Improving depression may help delay the deterioration of patients' IPF and frailty at certain stages.</p><p>Trial registration: Registration on UMIN-CTR. Registration number: UMIN000057161. Date of registration: February 27th, 2025.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03009-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anemia-related mortality trends in US older subjects, 1999 to 2019","authors":"Marco Zuin,&nbsp;Luigi Ferrucci,&nbsp;Giovanni Zuliani","doi":"10.1007/s40520-025-02982-0","DOIUrl":"10.1007/s40520-025-02982-0","url":null,"abstract":"<div><h3>Background</h3><p>Previous investigations showed that the prevalence of iron deficiency is increasing in United States (US). However, data regarding iron deficiency anemia-related mortality trends are lacking. We assess the trends in iron deficiency anemia-related mortality in US adults aged 65 years or older over the last two decades.</p><h3>Methods</h3><p>Iron-deficiency anemia-related deaths were ascertained using ICD-10 codes in the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2019. Age-adjusted mortality rates (AAMRs) were assessed using the Joinpoint regression modelling and expressed as estimated average annual percentage change (AAPC) and annual percent change (APC) with relative 95% confidence interval (95% CI), stratified by level of urbanization, sex, age, and race.</p><h3>Results</h3><p>Between 1999 and 2019, 30,540 US subjects aged ≥ 65 years old (11,986 men and 18,554 women) equating to 77.8 deaths per 100,000 or 27.9 deaths per week, had iron deficiency anemia listed as a cause of death. The AAMR remained stable from 1999 to 2013 [APC: -0.3, (95%CI: -0.9 to 0.1, <i>p</i> = 0.11)] and then sharply increased from 2013 to 2019 [APC: +9.7% (95%CI: 7.8 to 11.6), <i>p</i> &lt; 0.0001) without differences in sex, race, ethnicity or level of urbanization. The higher AAMRs were clustered in the Midwest [4.29 per 100,000 (95% CI: 4.20 to 4.38)] and in the South [3.35 per 100,000, 95% CI: 3.28 to 3.35)].</p><h3>Conclusions</h3><p>Over the last two decades the iron deficiency anemia-related mortality trends increased among US older subjects, without differences by sex, race, ethnicity or urbanicity.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02982-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health outcomes of sarcopenia: a consensus report by the outcome working group of the Global Leadership Initiative in Sarcopenia (GLIS)","authors":"Charlotte Beaudart,&nbsp;Julian Alcazar,&nbsp;Ivan Aprahamian,&nbsp;John A. Batsis,&nbsp;Yosuke Yamada,&nbsp;Carla M. Prado,&nbsp;Jean-Yves Reginster,&nbsp;Dolores Sanchez-Rodriguez,&nbsp;Wee Shiong Lim,&nbsp;Marc Sim,&nbsp;Stephan von Haehling,&nbsp;Jean Woo,&nbsp;Gustavo Duque,&nbsp;The Global Leadership Initiative in Sarcopenia (GLIS) group","doi":"10.1007/s40520-025-02995-9","DOIUrl":"10.1007/s40520-025-02995-9","url":null,"abstract":"<div><p>The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the GLIS has organized three different working groups (WGs), with the WG on outcomes of sarcopenia focusing on reporting its health outcomes to be measured in clinical practice once a diagnosis has been established. This includes sarcopenia definitions that better predict health outcomes, the preferred tools for measuring these outcomes, and the cutoffs defining normal and abnormal values. The present article synthesizes discussions and conclusions from this WG, composed of 13 key opinion leaders from different continents worldwide. Results rely on systematic reviews, meta-analyses, and relevant cohort studies in the field. With a high level of evidence, sarcopenia is significantly associated with a reduced quality of life, a higher risk of falls and fractures and a higher risk of mortality. Sarcopenia has been moderately associated with a higher risk of reduced instrumental activities of daily living (IADL). However, the GLIS WG found only inconclusive level of evidence to support associations between sarcopenia and higher risks of hospitalization, nursing home admission, mobility impairments, and reduced basic activities of daily living (ADL). This limitation underscores the scarcity of longitudinal studies, highlighting a barrier to understanding its progression and implications over time.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02995-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting countries to ensure the continuum of integrated care for older people","authors":"Yuka Sumi,&nbsp;Rachel Albone,&nbsp;Matteo Cesari","doi":"10.1007/s40520-025-02970-4","DOIUrl":"10.1007/s40520-025-02970-4","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02970-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts","authors":"Nazario Carrabba,&nbsp;Mattia Alexis Amico,&nbsp;Gherardo Busi,&nbsp;Matteo Vannini,&nbsp;Filippo Bruscoli,&nbsp;Salvatore Fortunato,&nbsp;Luciano Arcari,&nbsp;Emilio Di Lorenzo,&nbsp;Giampaolo Luzi,&nbsp;Francesco Clemenza,&nbsp;Francesco Amico,&nbsp;Giuseppe Pes,&nbsp;Marco Merlo,&nbsp;Gianfranco Sinagra,&nbsp;Giovambattista Desideri,&nbsp;Francesco Vetta,&nbsp;Alessandro Mugelli,&nbsp;Niccolo Marchionni,&nbsp;Alessandro Boccanelli,&nbsp;the PREVASC Working Group, Italian Society of Geriatrica Cardiology (SICGe)","doi":"10.1007/s40520-025-02937-5","DOIUrl":"10.1007/s40520-025-02937-5","url":null,"abstract":"<div><h3>Aims</h3><p>Valvular heart disease (VHD) is the third leading cause of cardiovascular morbidity, with its incidence and public health impact projected to increase significantly. This study adopts a novel perspective, focusing on elderly individuals residing in rural areas, highlighting the unique dynamics of small-town settings.</p><h3>Methods</h3><p>This multicenter, observational study was conducted from May 2022 to September 2023, under the coordination of the AOU Careggi Echo Core-Lab, which managed the entire screening program. In 10 small Italian villages, each municipality facilitated the enrollment of asymptomatic individuals aged ≥ 65 years, with no prior VHD history, through voluntary participation. Participants were grouped into three age categories (65–69, 70–74, and ≥ 75 years) and underwent a thorough evaluation, including a Quality of Life (QoL) questionnaire and comprehensive echocardiographic assessment focusing on VHD detection and grading.</p><h3>Results</h3><p>Among 1,113 participants, the prevalence and severity of VHD showed a significant increase with age (<i>p</i> &lt; 0.0001). Remarkably, 94% of individuals aged ≥ 75 years had at least one valvular defect, with 22.5% presenting moderate or severe valvulopathy, including a prevalence of 4.8% for moderate or severe aortic valve stenosis and 7.5% for mitral regurgitation. Right-sided valvulopathies followed a similar trend, affecting 71.9% of elderly participants. QoL evaluations revealed a generally positive perceived health status, with a mean score of 77 ± 16.</p><h3>Conclusions</h3><p>Our registry highlights that the prevalence of VHD in asymptomatic individuals over 65 years living in small Italian communities is substantial, increases with age, and is predominantly degenerative in etiology. Notably, most individuals with undiagnosed VHD perceived themselves as healthy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02937-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and waist circumference as key determinants of postoperative thrombosis and squatting recovery after unicompartmental knee arthroplasty","authors":"Xuyang Cao,&nbsp;Mengsha Wang,&nbsp;Zizi Zhao,&nbsp;Taotao Kong","doi":"10.1007/s40520-025-02974-0","DOIUrl":"10.1007/s40520-025-02974-0","url":null,"abstract":"<div><h3>Background</h3><p>Thrombosis is a common postoperative complication after unicompartmental knee arthroplasty (UKA), and the ability to squat is an important functional outcome reflecting recovery of knee function. This study aimed to investigate the factors influencing postoperative thrombosis as well as the ability to squat within 1 year after UKA.</p><h3>Methods</h3><p>Data from UKA patients were retrospectively analyzed and grouped based on the occurrence of thrombosis (including deep vein thrombosis and superficial vein thrombosis) and the ability to squat within 1 year. Factors affecting thrombosis and squatting were compared and analyzed using multifactorial logistic regression.</p><h3>Results</h3><p>Univariate analysis revealed that age (<i>P</i> = 0.014), pre-operative haemoglobin (<i>P</i> = 0.044), and gender (<i>P</i> = 0.047) were associated with thrombosis, while multifactorial analysis found age (<i>P</i> = 0.024) as the key factor. Regarding squatting ability, univariate analysis identified age (<i>P</i> = 0.018), body weight (<i>P</i> = 0.001), BMI (<i>P</i> = 0.001), waist circumference (<i>P</i> &lt; 0.001), pre-operative VAS score (<i>P</i> = 0.002), and family living conditions (<i>P</i> = 0.019) as influencing factors, with multifactorial analysis identifying waist circumference (<i>P</i> = 0.002) as a significant factor.</p><h3>Conclusions</h3><p>Older age increases the likelihood of thrombosis after UKA. Additionally, a larger waist circumference decreases the likelihood of squatting within 1 year after surgery.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02974-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Skill-Based multimodal intervention for dementia caregivers: impact on burden and anxiety","authors":"Doaa Said Amin Abdelhalim,&nbsp;Marwa Mostafa Ahmed,&nbsp;Hoda Abdou Hussein,&nbsp;Mai Diaa Sarhan,&nbsp;Ola Osama Khalaf","doi":"10.1007/s40520-025-02985-x","DOIUrl":"10.1007/s40520-025-02985-x","url":null,"abstract":"<div><h3>Background</h3><p>Dementia is a global health challenge affecting both patients and their caregivers, with family members often bearing the primary caregiving burden. In Egypt, where research on caregiver mental health is limited, interventions addressing caregiver burden and anxiety is critical.</p><h3>Aim</h3><p>To determine the effect of a psychoeducation and skill-based multimodal intervention on caregiver burden and anxiety.</p><h3>Methods</h3><p>A randomized controlled trial (RCT) involving 84 family caregivers. Participants were assigned to either the intervention group (<i>n</i> = 42), which received structured psychoeducation and skill-based training over six biweekly sessions, or the control group (<i>n</i> = 42), which received routine outpatient care. Caregiver burden and anxiety were assessed using the Zarit Burden Interview (ZBI) and the Generalized Anxiety Disorder Scale (GAD-7). Behavioral and psychological symptoms of dementia were evaluated using the Neuropsychiatric Inventory Questionnaire (NPI-Q).</p><h3>Results</h3><p>The sample consisted predominantly of women (79% in the intervention group, 69% in the control group), with daughters forming the largest caregiver subgroup (66.6% and 52.4%, respectively). The mean age of caregivers was 39.2 ± 4.2 years. After three months, caregivers in the intervention group exhibited a significant reduction in burden (ZBI median score: 24 vs. 34, <i>p</i> &lt; 0.0001) and anxiety (GAD-7 mean score: 6.15 vs. 9.4, <i>p</i> &lt; 0.0001) compared to the control group, however, NPI-Q scores remained unchanged.</p><h3>Conclusion</h3><p>A structured psychoeducation and skill-based intervention significantly reduces caregiver burden and anxiety. Implementing such programs in Egypt could improve the well-being of caregivers and individuals with dementia.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02985-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults produce more verbal false memories than younger adults: is it semantics or executive functioning?","authors":"Martina Cangelosi,&nbsp;Luca Rinaldi,&nbsp;Ton Dijkstra,&nbsp;Paola Palladino,&nbsp;Elena Cavallini","doi":"10.1007/s40520-024-02914-4","DOIUrl":"10.1007/s40520-024-02914-4","url":null,"abstract":"<div><h3>Background</h3><p>A verbal false memory occurs when one remembers a word (called “critical lure”) as part of a previously presented list despite its absence. This phenomenon may be linked to the semantic associations of the critical lure with actual list items.</p><h3>Aims</h3><p>We aimed to investigate the mechanisms behind the increase in verbal false memories with aging, evaluating whether this is due to a greater reliance on semantic processing or impaired executive functioning.</p><h3>Methods</h3><p>We employed the Deese-Roediger-McDermott (DRM) paradigm, presenting DRM word lists to two age groups: young adults and older adults. In addition, participants completed the Hayling Sentence Completion Test to assess inhibition and the Backward Digit Span Task to evaluate working memory.</p><h3>Results</h3><p>Our findings confirm that older adults experience more verbal false memories than younger participants. Results suggest that both semantic processing reliance and inhibition impairment contribute to the increase in false memories with aging, while working memory was not significantly related to false memory production.</p><h3>Discussion</h3><p>Older adults’ increased susceptibility to false memories appears to arise from an interplay between enhanced semantic reliance and inhibition deficits.</p><h3>Conclusions</h3><p>This study proposes a novel integration of semantic and executive mechanisms underlying the observed increase in false memories during aging, with inhibition playing an unexpected role in enhancing false memory susceptibility.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02914-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the coexistence of chronic kidney disease and sarcopenia with cardiovascular disease and mortality","authors":"Lijun Jiang,&nbsp;Liangliang Xu,&nbsp;Wen Sun,&nbsp;Keyu Bian,&nbsp;Yuan Wang","doi":"10.1007/s40520-025-03003-w","DOIUrl":"10.1007/s40520-025-03003-w","url":null,"abstract":"<div><h3>Background</h3><p>Chronic kidney disease (CKD) and sarcopenia are independently associated with adverse cardiovascular and mortality outcomes. However, the combined impact of CKD and sarcopenia remains poorly understood. To evaluate the combined effects of CKD and sarcopenia on cardiovascular disease (CVD) and mortality risks in a large population-based cohort.</p><h3>Methods</h3><p>We analyzed data from 477,380 participants in the UK Biobank, categorized into four groups based on the presence or absence of CKD and sarcopenia: Non-CKD Non-Sarcopenia, Non-CKD Sarcopenia, CKD Non-Sarcopenia, and CKD Sarcopenia. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD and mortality outcomes. Kaplan-Meier survival analyses compared event-free survival across the groups.</p><h3>Results</h3><p>Participants with both CKD and sarcopenia exhibited the highest risks across all outcomes compared to those without either condition. For stroke, the adjusted HR was 2.17 (95% CI: 1.65–2.86), significantly higher than CKD alone (HR: 1.69, 95% CI: 1.47–1.94) or sarcopenia alone (HR: 1.28, 95% CI: 1.03–1.59). Similar trends were observed for coronary artery disease (CAD) and heart failure (HF), with HRs of 1.53 (95% CI: 1.38–1.69) and 2.22 (95% CI: 1.99–2.47), respectively, in the CKD-sarcopenia group. The coexistence of CKD and sarcopenia was also associated with significantly elevated all-cause mortality (HR: 2.59, 95% CI: 2.17–3.09) and cardiovascular-specific mortality (HR: 4.08, 95% CI: 2.95–5.66).</p><h3>Conclusion</h3><p>The coexistence of CKD and sarcopenia significantly amplifies the risks of CVD and mortality, highlighting the need for integrated management strategies to address this high-risk population. Early detection and tailored interventions targeting these dual risk factors may mitigate their compounded burden and improve clinical outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03003-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}