Aging Clinical and Experimental Research最新文献

{"title":"Exploring the mediating role of telomere length in the association between physical activity and bone mineral density","authors":"Xiang Zhao,&nbsp;Yinhui Shi,&nbsp;Mengling Tang","doi":"10.1007/s40520-025-03176-4","DOIUrl":"10.1007/s40520-025-03176-4","url":null,"abstract":"<div><h3>Background</h3><p>Physical activity may mitigate osteoporosis progression by modulating telomere shortening processes.</p><h3>Aims</h3><p>To explore the mediating role of telomere length (TL) in the relationship between physical activity and bone mineral density (BMD).</p><h3>Methods</h3><p>This study enrolled 2,394 participants aged 50 years and older from the U.S. National Health and Nutrition examination Surveys. TL was measured by quantitative polymerase chain reaction (qPCR) method (TeloMean) and DNA methylation data (HorvathTelo), and accelerated telomere attrition was assessed through residual-based indices of TeloMeanAccel and HorvathTeloAccel. Physical activity was assessed via questionnaire and BMD was measured at multiple body sites. Multiple linear regression models were utilized to evaluate associations between TL metrics, physical activity, and BMD. Mediation analysis, restrict cubic spline (RCS) modeling, subgroup analyses and sensitivity analyses were further conducted.</p><h3>Results</h3><p>After adjusting for covariates, TL metrics of TeloMean and HorvathTelo were found significantly positive correlations with BMD. HorvathTeloAccel, reflecting accelerated telomere shortening, also exhibited significant association with BMD. Physical activity demonstrated a significant positive association with total BMD (β = 0.046, 95%CI: 0.004–0.088). Mediation analysis revealed that TeloMean and HorvathTelo accounted for 4.78% and 20.86% of the total effect of physical activity on BMD, respectively, while HorvathTeloAccel explained 5.24% of the observed association.</p><h3>Conclusion</h3><p>Reduced physical activity and accelerated telomere attrition were related with BMD decline, and TL partially mediated the association. These findings suggest that enhancing physical activity could mitigate telomere shortening and promote bone health.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03176-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between preoperative blood–brain barrier permeability and postoperative delirium in older patients undergoing cardiac surgery: a pilot study","authors":"Lichao Di,&nbsp;Peiying Huang,&nbsp;Yeju He,&nbsp;Jie Li,&nbsp;Yu Liu,&nbsp;Liwei Chi,&nbsp;Na Sun,&nbsp;Lining Huang","doi":"10.1007/s40520-025-03140-2","DOIUrl":"10.1007/s40520-025-03140-2","url":null,"abstract":"<div><h3>Background</h3><p>Postoperative delirium (POD) is a frequent and serious complication in older adults after cardiac surgery. Blood–brain barrier (BBB) dysfunction is implicated in cognitive decline, but its preoperative role in POD remains underexplored. This pilot study aimed to investigate the association between preoperative regional BBB permeability, assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and POD in older patients undergoing off-pump coronary artery bypass grafting (OPCABG). </p><h3>Methods</h3><p>This prospective observational pilot study, registered in the Chinese Clinical Trial Registry (ChiCTR2200063774), included patients aged ≥ 65 years scheduled for OPCABG. Preoperative BBB permeability (quantified as Ktrans) in the hippocampus, thalamus, frontal lobe, and temporal lobe, along with regional brain volumes and Montreal Cognitive Assessment-Basic (MoCA-B) scores, were assessed. POD was diagnosed using the 3-Minute Diagnostic Confusion Assessment Method (3D-CAM) or CAM-ICU for 5 postoperative days. Univariable and multivariable logistic regression analyses were performed to identify predictors of POD. Correlations between Ktrans, volume, and POD severity (CAM-S) were examined.</p><h3>Results</h3><p>Fifty patients (mean age 69.0 ± 3.3 years) were analyzed; 19 (38%) developed POD. In univariable analysis, higher preoperative Ktrans in the hippocampus (Odds Ratio [OR] 1.350, 95%CI 1.048–1.740, <i>P</i> = 0.020) and thalamus (OR 1.466, 95%CI 1.017–2.113, <i>P</i> = 0.040), lower MoCA-B scores (P = 0.020), and smaller hippocampal (OR 0.297, 95%CI 0.131–0.672, <i>P</i> = 0.004) and thalamic volumes (OR 0.304, 95%CI 0.121–0.766, <i>P</i> = 0.012) were associated with POD. However, in multivariable logistic regression including MoCA-B, Ktrans, and volumes, only lower MoCA-B scores (OR 0.697, 95%CI 0.513–0.947, <i>P</i> = 0.021) and smaller hippocampal volume (OR 0.322, 95%CI 0.105–0.992, P = 0.048) remained independent predictors of POD incidence. Preoperative hippocampal Ktrans correlated significantly with POD severity (CAM-S, r = 0.673, <i>P</i> = 0.002).</p><h3>Conclusion</h3><p>In this pilot study, while increased preoperative BBB permeability in the hippocampus and thalamus was associated with POD univariably, baseline cognitive function and hippocampal volume were stronger independent preoperative predictors of POD incidence after OPCABG. Higher preoperative hippocampal BBB permeability was associated with greater POD severity, suggesting a role for pre-existing BBB vulnerability in exacerbating delirium. These preliminary and exploratory findings warrant validation in larger, adequately powered cohorts and highlight the complex interplay of pre-existing brain vulnerabilities in POD development.</p><h3>Trial registration</h3><p>Chinese Clinical Trial Registry (ChiCTR2200063774; registered on 09/16/2022).</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03140-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticholinergic medication use and falls in Australian residential aged care: a retrospective multisite cohort study","authors":"Ying Xu,&nbsp;Magdalena Z. Raban,&nbsp;Ling Li,&nbsp;Amy D. Nguyen,&nbsp;S. Sandun Malpriya Silva,&nbsp;Guogui Huang,&nbsp;Gaston Arnolda,&nbsp;Johanna I. Westbrook,&nbsp;Nasir Wabe","doi":"10.1007/s40520-025-03147-9","DOIUrl":"10.1007/s40520-025-03147-9","url":null,"abstract":"<div><h3>Background</h3><p>Associations between anticholinergic load and falls remain understudied in residential aged care facilities (RACFs).</p><h3>Aims</h3><p>To examine associations between anticholinergic load and falls in the first year after entry to an RACF.</p><h3>Methods</h3><p>We aggregated routinely collected data from 27 RACFs in New South Wales, Australia. Anticholinergic load and falls were repeatedly measured for one year after residents first entered an RACF. Thirteen 28-day review periods were set. Associations between anticholinergic load in a review period and any falls in the next review period were examined, comprising 12 repeated measurements of associations. We included new residents aged ≥ 65 years, who entered an RACF between 1 July 2014 and 2 September 2021. Six scales were used: Anticholinergic Cognitive Burden (ACB), Anticholinergic Drug Scale (ADS), Anticholinergic Loading Scale (ALS), Anticholinergic Risk Scale (ARS), Chew’s list, and Clinician-rated Anticholinergic Score (CrAS). We used mixed-effect logistic regression models, adjusting for potential confounders. Facility was used as a cluster variable.</p><h3>Results</h3><p>For the 2300 residents (67.7% females), there were steady increases in mean anticholinergic load from the first to the 12th review period. Per one-point higher anticholinergic load was associated with an increased risk of falls, adjusted odds ratios: 1.08 (95% confidence interval[CI] 1.04, 1.12) using ACB, 1.11 (95%CI 1.06, 1.15) using ADS, 1.15 (95%CI 1.10, 1.21) using ALS, 1.10 (95%CI 1.04, 1.17) using ARS, 1.18 (95%CI 1.09, 1.27) using Chew’s list, and 1.14 (95%CI 1.10, 1.19) using CrAS.</p><h3>Conclusion</h3><p>Anticholinergic scales may be useful to inform falls prevention programs for new RACF residents.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03147-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a better understanding of patient expectations: ONCOPREMs-1 study—a qualitative study","authors":"Loubna Diouri,&nbsp;Fiona Ecarnot,&nbsp;Sophie Berjot,&nbsp;Alexandre Popiolek,&nbsp;Olivier Bouché,&nbsp;Damien Botsen,&nbsp;Amélie Lemoine,&nbsp;Stéphane Vignot,&nbsp;Coralie Barbe","doi":"10.1007/s40520-025-03148-8","DOIUrl":"10.1007/s40520-025-03148-8","url":null,"abstract":"<div><h3>Introduction</h3><p>As part of a broader study entitled OncoPREMs, which aims to develop a tool to assess patients’ experiences throughout their oncology care pathway, we explored patients’ perceptions and expectations from the first signs of illness to the post-cancer phase, as well as their experience of living with cancer.</p><h3>Methods</h3><p>A qualitative study was conducted using semi-structured interviews with patients who had been treated or were undergoing treatment for cancer in various healthcare facilities in France. Patients were recruited by healthcare professionals at their care sites.</p><h3>Results</h3><p>A total of 28 interviews were conducted between May and August 2023 (14 men, 14 women). The most common types of cancer were breast, digestive, and urological cancers. Thematic analysis identified several key themes related to the patient experience: the period of disease discovery and diagnosis; treatment follow-up and management of side effects; and the post-cancer phase or “living with cancer.”</p><h3>Conclusion</h3><p>The results of this study show that the different stages of the care pathway generally meet the expectations and needs of patients treated for cancer. However, patients expressed hopes for further developments, such as more support and guidance for their caregivers from healthcare professionals.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03148-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food as medicine: white and whole-grain bread consumption in relation to sarcopenia among older adults, insights from the Birjand Longitudinal Aging Study (BLAS)","authors":"Zohreh Sajadi Hezaveh,&nbsp;Farshad Sharifi,&nbsp;Hossein Fakhrzadeh,&nbsp;Huriye Khodabakhshi,&nbsp;Masoumeh Khorashadizadeh,&nbsp;Moloud Payab,&nbsp;Mahbube Ebrahimpur,&nbsp;Hanieh-Sadat Ejtahed,&nbsp;Mitra Moodi","doi":"10.1007/s40520-025-03162-w","DOIUrl":"10.1007/s40520-025-03162-w","url":null,"abstract":"<div><p>This study aimed to examine the association between energy-adjusted consumption patterns of different types of bread, including whole-grain and white bread, and the risk of sarcopenia in older adults. In this cross-sectional study, sarcopenia was assessed using three tests: appendicular skeletal muscle mass (ASMM), handgrip strength, and gait speed, in 1,325 older adults from the Birjand Longitudinal Aging Study (BLAS), conducted between September 2018 and April 2019. Bread consumption was evaluated through a semi-quantitative food frequency questionnaire. Consumption patterns of whole-grain and white bread were identified via factor analysis, adjusted for energy intake, and categorized into quartiles. In total, 28% of participants had sarcopenia. The highest quartile of the white bread pattern was associated with a 56% increased risk of low ASMM (OR: 1.56; 95% CI: 1.03 to 2.37, <i>P</i> = 0.04) and a twofold increase in the risk of low handgrip strength (OR: 2.00; 95% CI: 1.47 to 2.74, <i>P</i> &lt; 0.001). In contrast, higher adherence to the whole-grain bread pattern significantly reduced the risk of low handgrip strength (OR: 0.68; 95% CI: 0.48 to 0.95, <i>P</i> = 0.02). No significant association was found between either bread pattern and gait speed. Higher whole-grain bread intake was inversely associated with sarcopenia (OR: 0.63; 95% CI: 0.44 to 0.90, <i>P</i> = 0.01), while white bread intake increased the odds (OR: 1.64; 95% CI: 1.14 to 2.37, <i>P</i> = 0.01). Overall, greater whole-grain bread consumption was linked to better muscle strength, whereas white bread intake was associated with weaker muscles, muscle loss, and sarcopenia in older adults. Given the cross-sectional nature of this study, further research is needed to explore the underlying mechanisms and clarify the direction of these associations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03162-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remimazolam versus propofol for postoperative delirium prevention in geriatric surgery: A systematic review and meta-analysis of randomized controlled trials","authors":"Rui-jun Tong,&nbsp;Yue-zhong Lv,&nbsp;Ya-fen Shi,&nbsp;Lan Lai,&nbsp;Qi-hong Shen","doi":"10.1007/s40520-025-03166-6","DOIUrl":"10.1007/s40520-025-03166-6","url":null,"abstract":"<div><h3>Background</h3><p>As a novel ultra-short-acting benzodiazepine derivative, remimazolam’s impact on postoperative neurocognitive recovery remains poorly characterized. Our research specifically evaluated its influence on postoperative delirium (POD) incidence compared with propofol in the geriatric surgical population.</p><h3>Methods</h3><p>A comprehensive literature search was performed across four electronic databases, including the Cochrane Library, PubMed, Embase, and Web of Science, to identify eligible randomized controlled trials (RCTs). The methodological quality of the included studies was assessed using the Cochrane Collaboration’s risk of bias tool. Statistical analyses were performed using Review Manager 5.3 software; effect estimates were expressed as risk ratios (RR), standardized mean differences (SMD), and 95% confidence intervals (CI). The overall quality of the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.</p><h3>Results</h3><p>The meta-analysis incorporated five RCTs encompassing 1,368 patients. Pooled analysis revealed no statistically significant difference in POD incidence between the remimazolam and propofol groups (RR = 0.88, 95% CI: 0.58–1.33; <i>P</i> = 0.53). However, remimazolam administration was associated with a significant reduction in hypotensive events (RR = 0.55, 95% CI: 0.34–0.90; <i>P</i> &lt; 0.05). No between-group differences were detected in postoperative nausea and vomiting incidence.</p><h3>Conclusion</h3><p>The current meta-analysis provided evidence that perioperative remimazolam administration did not significantly increase the risk of POD in elderly surgical patients, while demonstrating clinically significant benefits in hemodynamic stability.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03166-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directional postural sway tendencies and static balance among community-dwelling older adults with depression and without cognitive impairment","authors":"Jethro Raphael M. Suarez,&nbsp;Veronica B. Decker,&nbsp;Joon-Hyuk Park,&nbsp;Nichole R. Lighthall,&nbsp;Michael Joseph S. Dino,&nbsp;Ladda Thiamwong","doi":"10.1007/s40520-025-03144-y","DOIUrl":"10.1007/s40520-025-03144-y","url":null,"abstract":"<div><h3>Background</h3><p>Depression is prevalent among older adults and is known to negatively affect balance, ultimately leading to falls. However, few studies have investigated the effect of depression on static balance metrics beyond postural sway distance and area of older adults without mild cognitive impairment (MCI).</p><h3>Aims</h3><p>To investigate if postural sway distance, sway area, medial-lateral (ML) sway range, anterior-posterior (AP) sway range, and center-of-pressure (COP) sway speed variability differed between non-cognitively impaired older adults with minimal-to-no depression (Minimally Depressive group) and mild-to-severe depression (Mildly-to-Severely Depressive group).</p><h3>Methods</h3><p>A total of 204 community-dwelling older adults were included. Depression was measured using the Patient Health Questionnaire-9 (PHQ-9), MCI using the Rowland Universal Dementia Assessment Scale (RUDAS), and static balance metrics using the Balance Tracking System (BTrackS). Mann-Whitney U tests determined differences between groups.</p><h3>Results</h3><p>Sway area, AP sway range, and ML sway range were significantly greater in the Mildly-to-Severely Depressive group than the Minimally Depressive group (<i>p</i> = 0.010, <i>p</i> = 0.016, and <i>p</i> = 0.031, respectively). Sway distance (<i>p</i> = 0.445) and COP sway speed variability (<i>p</i> = 0.193) were not significantly different between groups.</p><h3>Discussion</h3><p>The findings revealed greater sway area, as well as greater ranges in the AP and ML directions, in the Mildly-to-Severely Depressive group when compared to the Minimally Depressive Group. Reduced concentration and affected postural stabilization mechanisms driven by depression may have attributed to these results.</p><h3>Conclusions</h3><p>This study highlights the need for further understanding of how static balance metrics, such as directional sway, are affected by depression, thereby creating interventions tailored to individual’s postural sway characteristics to help reduce fall risk and improve balance.</p><h3>Trial registration</h3><p>ClinicalTrials.gov (NCT05778604).</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03144-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between intrinsic capacity and sarcopenia in older adults with type 2 diabetes: A cross-sectional study","authors":"Chia-Ling Lin,&nbsp;Hsueh-Ching Wu,&nbsp;Neng-Chun Yu,&nbsp;Yuan-Ching Liu,&nbsp;Chia-Ling Wu,&nbsp;Wu-Chien Chien","doi":"10.1007/s40520-025-03160-y","DOIUrl":"10.1007/s40520-025-03160-y","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the association between intrinsic capacity (IC) and sarcopenia among older adults with type 2 diabetes mellitus (T2D).</p><h3>Methods</h3><p>This cross-sectional study included 409 community-dwelling older adults with T2D (mean age: 71.2 ± 5.8 years; 207 men, 202 women). IC was assessed using the WHO framework across five domains: cognition (Brain Health Test), locomotion (Short Physical Performance Battery), vitality (Mini Nutritional Assessment–Short Form), sensory (vision and hearing tests), and psychological function (15-item Geriatric Depression Scale). Each impaired domain contributed one point to the total IC impairment score (range: 0–5), with higher scores indicating greater IC decline. Sarcopenia was defined based on the 2019 Asian Working Group for Sarcopenia (AWGS) criteria, including muscle mass, grip strength, and physical performance. Multiple logistic regression was used to examine associations between IC impairment and sarcopenia.</p><h3>Results</h3><p>The prevalence of sarcopenia was 13.4%, and the average IC impairment score was 0.8 ± 0.8. The most common impairments were hearing (42.1%) and vision (13.2%). Participants with sarcopenia had a significantly higher number of IC impairments. A greater number of impaired IC domains was associated with increased odds of sarcopenia. While locomotion and visual impairments showed a positive association, they were not statistically significant after adjusting for confounders.</p><h3>Conclusions</h3><p>Declines in IC, particularly in locomotion and sensory domains, were associated with higher likelihood of sarcopenia in older adults with T2D. Routine IC assessment may support early detection and preventive interventions in this high-risk population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03160-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity patterns and mortality in older adults: a two-cohort pooled analysis","authors":"Cecilia Damiano,&nbsp;Simona Costanzo,&nbsp;Benedetta Marcozzi,&nbsp;Teresa Panzera,&nbsp;Chiara Donfrancesco,&nbsp;Augusto Di Castelnuovo,&nbsp;Cinzia Lo Noce,&nbsp;Sara Magnacca,&nbsp;Federico Triolo,&nbsp;Maria Beatrice Zazzara,&nbsp;Luigi Palmieri,&nbsp;Licia Iacoviello,&nbsp;Graziano Onder,&nbsp;Davide Liborio Vetrano,&nbsp;for the BIO-SIGN Study Investigators","doi":"10.1007/s40520-025-03150-0","DOIUrl":"10.1007/s40520-025-03150-0","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background\u0000 <p>Different multimorbidity patterns can affect health trajectories and influence survival.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Aims\u0000 <p>We investigated their association with mortality in two population-based cohorts of older adults.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>Two Italian cohorts of randomly selected individuals (60–79 years old) from general population: CUORE (baseline 2008–2012) and Moli-sani (baseline 2005–2010). Latent Class Analysis used to identify homogeneous groups of multimorbid individuals (≥ 2 diseases) with similar underlying disease patterns. Cox regression models used to assess the association of multimorbidity patterns and all-cause mortality (end of follow-up 12/31/2019). Results pooled in a random-effects meta-analysis.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results\u0000 <p>Total samples of 3,695 individuals in CUORE (48% male, mean age 68.8 years [SD 5.6]) and 7,801 in Moli-sani (51% male, mean age 68.2 years [SD 5.4]). In both cohorts, six multimorbidity patterns were identified and named after their overexpressed diseases: <i>hypercholesterolemia; metabolic</i>,<i> depression and cancer; cardiometabolic and respiratory; gastrointestinal</i>,<i> genitourinary and depression; respiratory; unspecific</i> (i.e., no diseases overexpressed). Overall mortality rates were 1.66 per 100 person/years in CUORE and 1.85 per 100 person/years in Moli-sani. Compared to the multimorbidity-free group (&lt; 2 diseases), individuals displaying a <i>cardiometabolic and respiratory</i> pattern showed the highest mortality (pooled HR 2.62, 95% CI 2.15–3.10), followed by <i>unspecific</i> (pooled HR 1.45, 95% CI 1.21–1.68), <i>respiratory</i> (pooled HR 1.33, 95% CI 1.01–1.64) and <i>gastrointestinal</i>,<i> genitourinary and depression</i> (pooled HR 1.33, 95% CI 1.06–1.60).</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Discussion\u0000 <p>Multimorbidity patterns in older adults are differentially associated to shorter survival.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusions\u0000 <p>Their identification may help optimize clinical management by improving risk stratification, allowing for more targeted prevention and intervention strategies.</p>\u0000 \u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03150-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex‑specific effects of aging and glycemic control on the association of possible sarcopenia in older adults with type 2 diabetes: a cross-sectional study","authors":"Yi-Fang Huang,&nbsp;Shih-Ping Liu,&nbsp;Chih-Hsin Muo,&nbsp;Chen-Yi Lai,&nbsp;Chung-Ta Chang","doi":"10.1007/s40520-025-03159-5","DOIUrl":"10.1007/s40520-025-03159-5","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to investigate sex-specific associations and the synergistic effects of aging and glycemic control on the correlation of possible sarcopenia in older adults with type 2 diabetes mellitus (T2DM).</p><h3>Methods</h3><p>In the cross-sectional study of community-dwelling adults aged ≥ 60 years in New Taipei City, Taiwan, Sarcopenia status was classified using the Asian Working Group for Sarcopenia 2019 criteria into possible sarcopenia, sarcopenia, and severe sarcopenia. Categorical and continuous variables were compared using chi-square/Fisher’s exact tests and ANOVA. Sex-specific associations between glycemic control and sarcopenia were examined using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).</p><h3>Results</h3><p>5,728 participants (mean age 72.1 ± 6.1 years; 47.9% men) were enrolled. After adjustment, older women with T2DM had a higher odds of possible sarcopenia (OR = 2.07, 95% CI = 1.57–2.72). In women aged ≥ 70 years, both good and poor glycemic control were significantly correlated with possible sarcopenia (OR = 1.87 and 2.10; 95% CI = 1.16–3.04 and 1.43–3.07; p for trend &lt; 0.0001). T2DM patients with hypertension, ischemic heart disease (IHD), or depression showed increased sarcopenia association (OR = 1.71, 1.81, and 2.45, respectively). Poor glycemic control revealed increased odds of sarcopenia in those with hypertension (OR = 1.80) or IHD (OR = 2.42).</p><h3>Conclusions</h3><p>Glycemic control could be crucial in preventing possible sarcopenia, especially among older women with T2DM. Comorbid hypertension, IHD, or depression are significantly associated with sarcopenia in T2DM patients, particularly in the presence of poor glycemic control.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03159-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}