Aging Clinical and Experimental Research最新文献

{"title":"Remote monitoring in older adults with cancer, opportunities and challenges: a narrative review","authors":"Evelyne Liuu,&nbsp;Nicolò Matteo Luca Battisti,&nbsp;Angeline Galvin,&nbsp;Sarah Compton,&nbsp;Tania Kalsi,&nbsp;Marc Paccalin,&nbsp;Simon Valero,&nbsp;Pierre Soubeyran,&nbsp;Carly Welch","doi":"10.1007/s40520-025-03161-x","DOIUrl":"10.1007/s40520-025-03161-x","url":null,"abstract":"<div><h3>Background</h3><p>The ageing population has led to more cancer cases among older adults, who face higher risks of treatment-related adverse events, functional decline, and unplanned healthcare use. Traditional assessments like Eastern Cooperative Oncology Group and Karnofsky Performance Status lack sensitivity for this group, highlighting the need for new methods to monitor symptoms and functional changes in cancer care. This review examines remote monitoring technologies for older adults with cancer, focusing on their potential and challenges.</p><h3>Main body</h3><p>E-health tools such as electronic patient-reported outcomes (ePROs) and wearable devices enable continuous monitoring of symptoms, treatment toxicity, functional status, and adherence. Although benefits like fewer hospitalisations and better survival are shown in younger populations, evidence for older adults is limited. Early studies indicate these technologies are feasible and well-received by older patients but face barriers including digital literacy, cognitive and physical impairments, and healthcare system readiness. Devices like activity trackers and smartphones may detect functional decline and fall risk, though optimal intervention criteria remain unclear. Incorporating e-health into geriatric assessment and survivorship care could foster personalized, proactive management.</p><h3>Conclusion</h3><p>Remote monitoring technologies hold promise for enhancing symptom and functional assessment in older adults with cancer, supporting age-appropriate care. However, robust geriatric-specific evidence is lacking. Future research should address technological challenges, validate clinical thresholds, and assess long-term outcomes. Integrating these tools within multidisciplinary frameworks can improve care delivery throughout the cancer journey.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03161-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing mobile app design for older adults: systematic review of age-friendly design","authors":"Elahe Amouzadeh,&nbsp;Iman Dianat,&nbsp;Javad Faradmal,&nbsp;Mohammad Babamiri","doi":"10.1007/s40520-025-03157-7","DOIUrl":"10.1007/s40520-025-03157-7","url":null,"abstract":"<div><h3>Background</h3><p>With the rapid growth of mobile technology, ensuring accessibility and usability for older adults has become a critical concern. This systematic review evaluates existing age-friendly mobile app design research, identifying key usability barriers and effective strategies for improving accessibility.</p><h3>Methods</h3><p>This study reviews English-language research (Published between Jun. 2014 and Mar. 2025) on mobile applications for adults aged 60 + , focusing on user-centered design, usability testing, and age-friendly adaptations. It compares different levels of accessibility features and evaluates their impact on usability, satisfaction, and engagement across various settings. Studies were retrieved from four online databases (PubMed, Scopus, Web of Science, and IEEE Xplore).</p><h3>Results</h3><p>This systematic review initially reviewed 1,556 records. From these, 132 articles met the inclusion criteria. The findings highlight several essential design elements, including simplified navigation, enlarged text and touch targets, voice interaction, and error-tolerant interfaces. Participatory design methods enhanced usability and satisfaction, demonstrating the importance of co-designing applications with older users. However, challenges like cognitive overload, lack of digital literacy, and accessibility barriers persist.</p><h3>Conclusion</h3><p>The review emphasizes the need for future research on Artificial Intelligence-driven personalization, long-term usability studies, and culturally inclusive mobile applications. By integrating age-friendly design principles, developers can enhance digital inclusion, promote independence, and improve the overall well-being of older adults in an increasingly digital world.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03157-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term (current) aspirin use and sepsis-related delirium in elderly patients: a retrospective cohort study","authors":"Xin Liang,&nbsp;Lubin Sun,&nbsp;Na Jiang,&nbsp;Xinya Li,&nbsp;Tanjian Li,&nbsp;Jun Lyu,&nbsp;Yu Wang","doi":"10.1007/s40520-025-03152-y","DOIUrl":"10.1007/s40520-025-03152-y","url":null,"abstract":"<div><h3>Background</h3><p>Driven by the global aging trend, the prognosis of elderly patients with sepsis has garnered increasing attention. Sepsis-associated delirium (SAD), a common manifestation of elderly patients with sepsis, is frequently linked to poor clinical outcomes. Despite its prevalence, effective preventive measures remain lacking. Pharmacological interventions have emerged as promising components of a comprehensive strategy for the treatment and prevention of delirium. Among them, aspirin—renowned for its anti-inflammatory properties, affordability, and safety—may hold particular promise, given the central role of inflammation in the pathogenesis of both sepsis and delirium. Early initiation of anti-inflammatory therapy may offer a more effective approach to preventing SAD and enhancing patient outcomes.</p><h3>Aims</h3><p>To investigate the association between long-term (current) aspirin use and the incidence of SAD in elderly septic patients.</p><h3>Methods</h3><p>We extracted and analyzed data from 9145 elderly septic patients. The primary outcome, SAD, was analyzed using multivariable logistic regression to explore the correlation between long-term (current) aspirin use and the incidence of SAD. To ensure the robustness of the results, inverse probability of treatment weighting was used to adjust Intergroup relations. Finally, subgroup analyses were conducted.</p><h3>Results</h3><p>765 elderly septic patients were long-term (current) aspirin users, with a SAD incidence rate of 31.9% (244/765). In contrast, 8380 elderly septic patients without a history of long-term (current) aspirin use had a SAD incidence rate of 46.1% (3863/8380). After adjusting for 49 covariates, the multivariable logistic regression results showed that long-term (current) aspirin use was negatively associated with the risk of SAD (adjusted OR: 0.78, <i>p</i> &lt; 0.001). Even after balancing group differences through inverse probability treatment weighting, the results remained stable.</p><h3>Conclusions</h3><p>In elderly patients, long-term (current) aspirin use is negatively associated with the incidence of SAD and is also linked to improved clinical outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03152-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture","authors":"Varvara Chatzipetrou,&nbsp;Thierry Chevalley,&nbsp;Ivan Padlina,&nbsp;Marina Portela,&nbsp;Serge Ferrari,&nbsp;Emmanuel Biver","doi":"10.1007/s40520-025-03154-w","DOIUrl":"10.1007/s40520-025-03154-w","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background and aims\u0000 <p>The incidence of fragility fractures is increasing among community-dwelling postmenopausal women. Sarcopenia and obesity are significant risk factors for fractures, independent of osteoporosis. This study aims to investigate the prevalence of sarcopenia and obesity, as well as bone microstructure, according to osteoporotic status and fracture sites in older women with recent low-trauma fractures.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>This cross-sectional study included 135 community-dwelling postmenopausal women aged 65 and older, evaluated within six months of experiencing a low-trauma fracture (resulting from a fall from standing height or less) occurring at the humerus, proximal femur, vertebrae, pelvis, forearm, or ankle. Participants were recruited either prospectively through the Fracture Liaison Service (FLS) at the Bone Disease Department of Geneva University Hospitals (HUG) (<i>n</i> = 90) or retrospectively from the Geneva Retirees Cohort (GERICO) (<i>n</i> = 45). Bone mineral density (BMD) and body composition were assessed using dual-energy X-ray absorptiometry (DXA), muscle strength was measured by handgrip strength (HGS), and bone microstructure was evaluated using high-resolution peripheral quantitative computed tomography (HR-pQCT).</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results and discussion\u0000 <p>The prevalence of sarcopenia varied, with the overall prevalence across all definitions being 25%. It was significantly higher in osteoporotic women than in women with normal BMD (39% versus 6%, respectively, <i>p</i> = 0.014) and osteopenia (39% versus 20% respectively, <i>p</i> &lt; 0.05). The prevalence of obesity was 24%, with particularly high rates observed among women with normal BMD (61%) and those with ankle or humerus fractures (43%, and 38%, respectively). Notably, 33% of women with major osteoporotic fractures (MOF) presented with normal BMD and without sarcopenia or obesity.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusions\u0000 <p>A significant proportion of women with apparent low-trauma MOF does not have osteoporosis nor alterations of body composition (sarcopenia or obesity). The determinants of fracture risk in these women remain unclear and further investigations are required to better address secondary fracture prevention in this context.</p>\u0000 \u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03154-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty","authors":"Fan Yang,&nbsp;Mengjuan Xue,&nbsp;Han Xu,&nbsp;Ouyang Li,&nbsp;Dayoung Kim,&nbsp;Bin Lu,&nbsp;Zhijun Bao","doi":"10.1007/s40520-025-03149-7","DOIUrl":"10.1007/s40520-025-03149-7","url":null,"abstract":"<div>\u0000 \u0000 <p>Aging-related frailty increases the risk of falls, disability, and mortality. Frailty is linked to abnormalities in whole-body metabolism. However, the causal relationship between circulating metabolic traits and frailty remains unclear. This study aims to clarify the causal effects of circulating metabolites on frailty. We used bidirectional two sample and multivariable Mendelian Randomization (MVMR) methods to assess associations between circulating metabolites and the Frailty Index (FI). Genetic data on relevant single-nucleotide polymorphisms (SNPs) were obtained from publicly available genome-wide association studies (GWAS). Five MR methods were employed: Inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods were used for Mendelian Randomization (MR) analysis. MVMR analyses examined the effects of selected circulating metabolites (identified via multivariate LASSO regression), obesity, alcohol consumption, and sleep disorders on FI. Preliminary analyses identified 12 circulating metabolites as potential frailty risk factors, while secondary analyses revealed 25 circulating metabolites. Notably, MVMR established a causal relationship between free cholesterol in large low-density lipoprotein (LDL) and frailty. This study establishes a causal link between free cholesterol in large LDL and frailty risk based on genetic evidence, potentially guiding targeted prevention strategies.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03149-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic bacteria enriched in the oral microbiota might be associated with recurrent pulmonary infections in elderly individuals","authors":"Jingyi Xu,&nbsp;Ruyi Qu,&nbsp;Keke Yang,&nbsp;Yuezhu Wang,&nbsp;Meiyun Nie,&nbsp;Xiaodong Qi,&nbsp;Huajun Zheng,&nbsp;Ling Yang","doi":"10.1007/s40520-025-03141-1","DOIUrl":"10.1007/s40520-025-03141-1","url":null,"abstract":"<div><h3>Background and aims</h3><p>Pulmonary infections are a major health concern for the elderly, because of their high morbidity and mortality rates. With the growing world’s aging population, it is crucial to prioritize the health of elderly individuals. This study aimed to explore the associations between oral and gut microbiota and pulmonary infections.</p><h3>Methods</h3><p>Throat swabs and stool samples were collected from elderly patients aged 78–98 years and divided into four groups: Control, Infection, Re-Infection, and Re-None. The microbiota were analyzed via 16S rRNA gene sequencing, and the functional predictions were imputed using PICRUSt with MetaCyc pathway annotation.</p><h3>Results</h3><p>Significant differences were observed in oral and gut microbiota diversity between the control and test groups. Patients with pneumonia showed a significant increase in <i>Staphylococcus aureus</i> abundance in the oral microbiota compared to the Control group, while those with recurrent pneumonia showed elevated, <i>Klebsiella pneumoniae</i> levels. In the gut microbiota, <i>Enterococcus hirae</i> alone that was significantly enriched in all three test groups. Furthermore, PICRUSt2 analysis indicated an increased relative abundance of genes associated with the degradation of D-glucarate and D-galactarate pathways in patients with recurrent infections.</p><h3>Conclusion</h3><p>Oral and gut microbiota diversity showed significant differences between patients with recurrent pneumonia and common pneumonia pneumonia-infected patients. The higher prevalence of both <i>S. aureus</i> and <i>K. pneumoniae</i> in the oral microbiota offers crucial insights into the pneumonia etiology. Specifically, the increased abundance of <i>K. pneumoniae</i> may contribute significantly to the heightened lung infections susceptibility among elderly individuals.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03141-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of pulmonary function with the risk of incident Alzheimer’s disease: a prospective cohort and Mendelian randomization study","authors":"Ya-Nan Zheng,&nbsp;Peng Qiu,&nbsp;Hui-Huan Luo,&nbsp;Ren-Jie Chen,&nbsp;Xue-Qiang Wang,&nbsp;Pei-Jie Chen","doi":"10.1007/s40520-025-03151-z","DOIUrl":"10.1007/s40520-025-03151-z","url":null,"abstract":"<div><h3>Introduction</h3><p>The causal association between pulmonary function and Alzheimer’s disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.</p><h3>Methods</h3><p>We conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), FEV₁/FVC ratio, percentage of predicted normal value of FEV₁ (FEV₁% pred), and peak expiratory flow (PEF) were measured at baseline. Longitudinal associations were investigated using cox-proportional hazard models. We conducted univariate and multivariable MR analyses on genome-wide association study (GWAS) data from 421,986 Europeans for FEV₁, FVC, and PEF. Inverse-variance weighting was employed as the primary MR analysis approach.</p><h3>Results</h3><p>Over a median follow-up of 12.8 years (10.3–15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32–2.48; FEV₁), 1.97 (1.44–2.69; FVC), and 1.86 (1.39–2.47; PEF). In the MR study, genetically determined high FEV₁ was associated with a decreased risk of AD (odds ratio: 0.68, 95% CI: 0.53–0.88). The results remained robust after sensitivity and multivariable MR analyses.</p><h3>Conclusion</h3><p>Our findings suggest the potential causal association between high FEV₁ and decreased risk of AD.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03151-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elder abuse in Europe’s “most elderly” city: an update of the phenomenon based on the cases reported to the Penal Court of Genoa from 2020 to 2023 and literature review","authors":"Martina Drommi,&nbsp;Rosario Barranco,&nbsp;Francesco Ventura,&nbsp;Andrea Molinelli","doi":"10.1007/s40520-025-03153-x","DOIUrl":"10.1007/s40520-025-03153-x","url":null,"abstract":"<div><h3>Background</h3><p>Elder abuse is a global problem, with literature indicating that one in six elderly individuals is a potential victim.</p><h3>Aims</h3><p>In this study, we delve into reported cases of elder abuse brought to the attention of the Judicial Authority in the Genoa area between 2020 and 2023. Our objective is twofold: first, to conduct a detailed analysis of epidemiological data to quantify the incidence and characteristics of this phenomenon; second, to critically examine the medico-legal and clinical aspects emerging from these cases, aiming to contribute to a deeper understanding and improved management of this social and health issue.</p><h3>Methods</h3><p>We analysed data on reports of abuse processed by the Court of Genoa from 2020 to 2023. These findings were then compared with data from the previous 10-year period and with existing literature.</p><h3>Results</h3><p>A total of 1011 reports related to offenses concerning violations of family assistance obligations, abuse of means of correction or discipline, maltreatment of family members and cohabitants, personal injury, abandonment of minors or incapacitated persons, and circumvention of incapacitated persons were identified. Among 24,144 judgments, 200 relevant to potential elder abuse situations were examined.</p><h3>Discussion</h3><p>The findings indicate that abuse was predominantly perpetrated within the domestic setting and primarily by the victims’ relatives. Key risk factors identified included the victim’s female gender, their dependency on others, and the perpetrator’s concurrent mental illness or substance abuse.</p><h3>Conclusion</h3><p>Elder abuse, therefore, constitutes an extremely complex and heterogeneous problem, presenting an infinite number of manifestations and facets, making it difficult to perceive and identify.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing active aging, its predictors and consequences","authors":"Taina Rantanen,&nbsp;Katja Lindeman,&nbsp;Erja Portegijs","doi":"10.1007/s40520-025-03123-3","DOIUrl":"10.1007/s40520-025-03123-3","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global burden of varicella and herpes zoster in adults aged 65 years and older: a comprehensive analysis based on the global burden of disease 2021","authors":"Jiang Li,&nbsp;Zhaofeng Jin,&nbsp;Wei Yang,&nbsp;Meichen Jin,&nbsp;Jun Niu","doi":"10.1007/s40520-025-03142-0","DOIUrl":"10.1007/s40520-025-03142-0","url":null,"abstract":"<div><h3>Background</h3><p>The global population is aging at an accelerated rate. There is a lack of data on the burden of varicella and herpes zoster in adults aged 65 years and older.</p><h3>Objective</h3><p>This study assesses the global burden of varicella and herpes zoster among adults aged 65 and older from 1992 to 2021.</p><h3>Methods</h3><p>We used Global Burden of Disease (GBD) 2021 to identify the number and rates of incidence and disability-adjusted life years (DALYs) of varicella and herpes zoster in adults aged 65 and older.</p><h3>Results</h3><p>From 1992 to 2021, The age-standardized incidence rate (ASIR) of varicella and herpes zoster increased among adults aged 65 years and older, while the age-standardized death rate (ASDR) decreased. There were differences in the burden of varicella-zoster among adults aged 65 years and older by among sexes, ages, and regions. The health inequalities analysis showed an improvement among countries.</p><h3>Conclusion</h3><p>From 1992 to 2021, the global burden of varicella zoster among adults aged 65 and older has changed significantly. The ASIR of varicella and herpes zoster increased, but ASDR decreased. Despite the notable advancement in health equity across countries, the burden persists disproportionately among populations in low-SDI regions.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}