Aging Clinical and Experimental Research最新文献

{"title":"Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture","authors":"Varvara Chatzipetrou,&nbsp;Thierry Chevalley,&nbsp;Ivan Padlina,&nbsp;Marina Portela,&nbsp;Serge Ferrari,&nbsp;Emmanuel Biver","doi":"10.1007/s40520-025-03154-w","DOIUrl":"10.1007/s40520-025-03154-w","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background and aims\u0000 <p>The incidence of fragility fractures is increasing among community-dwelling postmenopausal women. Sarcopenia and obesity are significant risk factors for fractures, independent of osteoporosis. This study aims to investigate the prevalence of sarcopenia and obesity, as well as bone microstructure, according to osteoporotic status and fracture sites in older women with recent low-trauma fractures.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>This cross-sectional study included 135 community-dwelling postmenopausal women aged 65 and older, evaluated within six months of experiencing a low-trauma fracture (resulting from a fall from standing height or less) occurring at the humerus, proximal femur, vertebrae, pelvis, forearm, or ankle. Participants were recruited either prospectively through the Fracture Liaison Service (FLS) at the Bone Disease Department of Geneva University Hospitals (HUG) (<i>n</i> = 90) or retrospectively from the Geneva Retirees Cohort (GERICO) (<i>n</i> = 45). Bone mineral density (BMD) and body composition were assessed using dual-energy X-ray absorptiometry (DXA), muscle strength was measured by handgrip strength (HGS), and bone microstructure was evaluated using high-resolution peripheral quantitative computed tomography (HR-pQCT).</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results and discussion\u0000 <p>The prevalence of sarcopenia varied, with the overall prevalence across all definitions being 25%. It was significantly higher in osteoporotic women than in women with normal BMD (39% versus 6%, respectively, <i>p</i> = 0.014) and osteopenia (39% versus 20% respectively, <i>p</i> &lt; 0.05). The prevalence of obesity was 24%, with particularly high rates observed among women with normal BMD (61%) and those with ankle or humerus fractures (43%, and 38%, respectively). Notably, 33% of women with major osteoporotic fractures (MOF) presented with normal BMD and without sarcopenia or obesity.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusions\u0000 <p>A significant proportion of women with apparent low-trauma MOF does not have osteoporosis nor alterations of body composition (sarcopenia or obesity). The determinants of fracture risk in these women remain unclear and further investigations are required to better address secondary fracture prevention in this context.</p>\u0000 \u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03154-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty","authors":"Fan Yang,&nbsp;Mengjuan Xue,&nbsp;Han Xu,&nbsp;Ouyang Li,&nbsp;Dayoung Kim,&nbsp;Bin Lu,&nbsp;Zhijun Bao","doi":"10.1007/s40520-025-03149-7","DOIUrl":"10.1007/s40520-025-03149-7","url":null,"abstract":"<div>\u0000 \u0000 <p>Aging-related frailty increases the risk of falls, disability, and mortality. Frailty is linked to abnormalities in whole-body metabolism. However, the causal relationship between circulating metabolic traits and frailty remains unclear. This study aims to clarify the causal effects of circulating metabolites on frailty. We used bidirectional two sample and multivariable Mendelian Randomization (MVMR) methods to assess associations between circulating metabolites and the Frailty Index (FI). Genetic data on relevant single-nucleotide polymorphisms (SNPs) were obtained from publicly available genome-wide association studies (GWAS). Five MR methods were employed: Inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods were used for Mendelian Randomization (MR) analysis. MVMR analyses examined the effects of selected circulating metabolites (identified via multivariate LASSO regression), obesity, alcohol consumption, and sleep disorders on FI. Preliminary analyses identified 12 circulating metabolites as potential frailty risk factors, while secondary analyses revealed 25 circulating metabolites. Notably, MVMR established a causal relationship between free cholesterol in large low-density lipoprotein (LDL) and frailty. This study establishes a causal link between free cholesterol in large LDL and frailty risk based on genetic evidence, potentially guiding targeted prevention strategies.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03149-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic bacteria enriched in the oral microbiota might be associated with recurrent pulmonary infections in elderly individuals","authors":"Jingyi Xu,&nbsp;Ruyi Qu,&nbsp;Keke Yang,&nbsp;Yuezhu Wang,&nbsp;Meiyun Nie,&nbsp;Xiaodong Qi,&nbsp;Huajun Zheng,&nbsp;Ling Yang","doi":"10.1007/s40520-025-03141-1","DOIUrl":"10.1007/s40520-025-03141-1","url":null,"abstract":"<div><h3>Background and aims</h3><p>Pulmonary infections are a major health concern for the elderly, because of their high morbidity and mortality rates. With the growing world’s aging population, it is crucial to prioritize the health of elderly individuals. This study aimed to explore the associations between oral and gut microbiota and pulmonary infections.</p><h3>Methods</h3><p>Throat swabs and stool samples were collected from elderly patients aged 78–98 years and divided into four groups: Control, Infection, Re-Infection, and Re-None. The microbiota were analyzed via 16S rRNA gene sequencing, and the functional predictions were imputed using PICRUSt with MetaCyc pathway annotation.</p><h3>Results</h3><p>Significant differences were observed in oral and gut microbiota diversity between the control and test groups. Patients with pneumonia showed a significant increase in <i>Staphylococcus aureus</i> abundance in the oral microbiota compared to the Control group, while those with recurrent pneumonia showed elevated, <i>Klebsiella pneumoniae</i> levels. In the gut microbiota, <i>Enterococcus hirae</i> alone that was significantly enriched in all three test groups. Furthermore, PICRUSt2 analysis indicated an increased relative abundance of genes associated with the degradation of D-glucarate and D-galactarate pathways in patients with recurrent infections.</p><h3>Conclusion</h3><p>Oral and gut microbiota diversity showed significant differences between patients with recurrent pneumonia and common pneumonia pneumonia-infected patients. The higher prevalence of both <i>S. aureus</i> and <i>K. pneumoniae</i> in the oral microbiota offers crucial insights into the pneumonia etiology. Specifically, the increased abundance of <i>K. pneumoniae</i> may contribute significantly to the heightened lung infections susceptibility among elderly individuals.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03141-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of pulmonary function with the risk of incident Alzheimer’s disease: a prospective cohort and Mendelian randomization study","authors":"Ya-Nan Zheng,&nbsp;Peng Qiu,&nbsp;Hui-Huan Luo,&nbsp;Ren-Jie Chen,&nbsp;Xue-Qiang Wang,&nbsp;Pei-Jie Chen","doi":"10.1007/s40520-025-03151-z","DOIUrl":"10.1007/s40520-025-03151-z","url":null,"abstract":"<div><h3>Introduction</h3><p>The causal association between pulmonary function and Alzheimer’s disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.</p><h3>Methods</h3><p>We conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), FEV₁/FVC ratio, percentage of predicted normal value of FEV₁ (FEV₁% pred), and peak expiratory flow (PEF) were measured at baseline. Longitudinal associations were investigated using cox-proportional hazard models. We conducted univariate and multivariable MR analyses on genome-wide association study (GWAS) data from 421,986 Europeans for FEV₁, FVC, and PEF. Inverse-variance weighting was employed as the primary MR analysis approach.</p><h3>Results</h3><p>Over a median follow-up of 12.8 years (10.3–15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32–2.48; FEV₁), 1.97 (1.44–2.69; FVC), and 1.86 (1.39–2.47; PEF). In the MR study, genetically determined high FEV₁ was associated with a decreased risk of AD (odds ratio: 0.68, 95% CI: 0.53–0.88). The results remained robust after sensitivity and multivariable MR analyses.</p><h3>Conclusion</h3><p>Our findings suggest the potential causal association between high FEV₁ and decreased risk of AD.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03151-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elder abuse in Europe's \"most elderly\" city: an update of the phenomenon based on the cases reported to the Penal Court of Genoa from 2020 to 2023 and literature review.","authors":"Martina Drommi, Rosario Barranco, Francesco Ventura, Andrea Molinelli","doi":"10.1007/s40520-025-03153-x","DOIUrl":"10.1007/s40520-025-03153-x","url":null,"abstract":"<p><strong>Background: </strong>Elder abuse is a global problem, with literature indicating that one in six elderly individuals is a potential victim.</p><p><strong>Aims: </strong>In this study, we delve into reported cases of elder abuse brought to the attention of the Judicial Authority in the Genoa area between 2020 and 2023. Our objective is twofold: first, to conduct a detailed analysis of epidemiological data to quantify the incidence and characteristics of this phenomenon; second, to critically examine the medico-legal and clinical aspects emerging from these cases, aiming to contribute to a deeper understanding and improved management of this social and health issue.</p><p><strong>Methods: </strong>We analysed data on reports of abuse processed by the Court of Genoa from 2020 to 2023. These findings were then compared with data from the previous 10-year period and with existing literature.</p><p><strong>Results: </strong>A total of 1011 reports related to offenses concerning violations of family assistance obligations, abuse of means of correction or discipline, maltreatment of family members and cohabitants, personal injury, abandonment of minors or incapacitated persons, and circumvention of incapacitated persons were identified. Among 24,144 judgments, 200 relevant to potential elder abuse situations were examined.</p><p><strong>Discussion: </strong>The findings indicate that abuse was predominantly perpetrated within the domestic setting and primarily by the victims' relatives. Key risk factors identified included the victim's female gender, their dependency on others, and the perpetrator's concurrent mental illness or substance abuse.</p><p><strong>Conclusion: </strong>Elder abuse, therefore, constitutes an extremely complex and heterogeneous problem, presenting an infinite number of manifestations and facets, making it difficult to perceive and identify.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"242"},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing active aging, its predictors and consequences.","authors":"Taina Rantanen, Katja Lindeman, Erja Portegijs","doi":"10.1007/s40520-025-03123-3","DOIUrl":"10.1007/s40520-025-03123-3","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"241"},"PeriodicalIF":3.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global burden of varicella and herpes zoster in adults aged 65 years and older: a comprehensive analysis based on the global burden of disease 2021.","authors":"Jiang Li, Zhaofeng Jin, Wei Yang, Meichen Jin, Jun Niu","doi":"10.1007/s40520-025-03142-0","DOIUrl":"10.1007/s40520-025-03142-0","url":null,"abstract":"<p><strong>Background: </strong>The global population is aging at an accelerated rate. There is a lack of data on the burden of varicella and herpes zoster in adults aged 65 years and older.</p><p><strong>Objective: </strong>This study assesses the global burden of varicella and herpes zoster among adults aged 65 and older from 1992 to 2021.</p><p><strong>Methods: </strong>We used Global Burden of Disease (GBD) 2021 to identify the number and rates of incidence and disability-adjusted life years (DALYs) of varicella and herpes zoster in adults aged 65 and older.</p><p><strong>Results: </strong>From 1992 to 2021, The age-standardized incidence rate (ASIR) of varicella and herpes zoster increased among adults aged 65 years and older, while the age-standardized death rate (ASDR) decreased. There were differences in the burden of varicella-zoster among adults aged 65 years and older by among sexes, ages, and regions. The health inequalities analysis showed an improvement among countries.</p><p><strong>Conclusion: </strong>From 1992 to 2021, the global burden of varicella zoster among adults aged 65 and older has changed significantly. The ASIR of varicella and herpes zoster increased, but ASDR decreased. Despite the notable advancement in health equity across countries, the burden persists disproportionately among populations in low-SDI regions.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"240"},"PeriodicalIF":3.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The trajectory of frailty index and its association with rapid decline in kidney function and the incidence of chronic kidney disease: evidence from the China health and retirement longitudinal study.","authors":"Wei-Zhen Tang, Bo-Yuan Deng, Qin-Yu Cai, Yong-Heng Wang, Qin-Hao Yang, Hong-Yu Xu, Wang Qi Rui Liu, Tai-Hang Liu, Fei Han, Yu-Ming Zhu","doi":"10.1007/s40520-025-03146-w","DOIUrl":"10.1007/s40520-025-03146-w","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the association between the frailty index trajectory in older adults from a longitudinal cohort and rapid decline in kidney function as well as the incidence of chronic kidney disease (CKD).</p><p><strong>Method: </strong>This study included 4,207 participants aged 45 and above from the China Health and Retirement Longitudinal Study (CHARLS), who underwent baseline assessments in 2011-2012 and were followed up in 2013 and 2015. The study selected 31 items to construct the frailty index (FI), with the FI value positively correlated with the degree of frailty in individuals. The FI trajectories were determined using latent class trajectory modeling (LCTM). The primary outcome event was rapid decline in kidney function, with the incidence of CKD also being explored. Binary logistic regression analysis was used to examine the association between these trajectories and kidney disease. The covariates include basic demographic variables, medical history, and biochemical indicators. In addition, the dose-response relationship between cumulative frailty indicators and rapid decline in kidney function and CKD was explored within each frailty index trajectory group. We conducted subgroup and interaction analyses to explore the impact of various characteristics on this relationship. Finally, eGFRcr was used to assess kidney function and validate the consistency of previous findings.</p><p><strong>Results: </strong>Participants were divided into three FI trajectories: Low-stable trajectory, Moderate-stable frailty index trajectory, and Moderate-increase trajectory, which accounted for 50.68%, 37.58%, and 11.74% of the study population, respectively. Compared to participants in the Low-stable frailty index trajectory group, those in the Moderate-increase FI trajectory group had a significantly higher risk of rapid decline in kidney function, with an adjusted OR of 1.589 (95% CI, 1.013-2.442). However, the trend ORs for cumulative FI within each FI group did not show statistical significance, suggesting the reasonableness of the trajectory classification. Finally, the analysis using eGFRcr to assess kidney function was consistent with the primary results.</p><p><strong>Conclusion: </strong>A higher FI trajectory is associated with an increased risk of rapid decline in kidney function. The findings underscore the critical importance of monitoring the dynamic changes in frailty among middle-aged and older adults.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"238"},"PeriodicalIF":3.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household solid fuel use heightens the risk of dual sensory impairment in middle-aged and older Chinese adults.","authors":"Jinglei Jiang, Huijuan Lou, Yu Yao, Chenxuan Dong, Yuanyuan Ji, Yahui Sun, Wanning Gao, Yufeng Wang, Deyu Cong","doi":"10.1007/s40520-025-03088-3","DOIUrl":"10.1007/s40520-025-03088-3","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of dual sensory impairment (DSI), which encompasses both hearing impairment (HI) and vision impairment (VI), exceeds 10% among middle-aged and older populations worldwide. Recently, the impact of environmental factors on DSI has drawn more attention. Limited knowledge exists regarding the impact of household solid fuel use on the prevalence of DSI among Chinese adults. Therefore, the objective of this study is to investigate the implications of household solid fuel utilization on the prevalence of DSI, as well as on individual VI or HI.</p><p><strong>Methods: </strong>We conducted a retrospective analysis using data from the most recent four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study (CHARLS), which started its survey in 2011. Using time-dependent Cox regression, we examined the association between household solid fuel use and the prevalence of DSI. The models included multiplicative interaction terms for stratified analysis, and likelihood-ratio tests were conducted to complete the interaction analysis. Additionally, decision tree models were employed to identify individuals at high risk of DSI.</p><p><strong>Results: </strong>Among the 1,228 respondents, 587 (47.80%) were female, and median age of 55 years. Over a 7-year follow-up period, 774 (68.62%) participants developed DSI. In comparison to individuals who use clean fuel, those who utilize solid fuel for cooking had an elevated risk of DSI (HR = 1.191; 95% CI: 1.018-1.391). Similarly, the risk of HI was 17.7% higher (95% CI: 1.015-1.365) among individuals using solid fuels for cooking compared to those using clean fuels, and 24.9% higher (95% CI: 1.032-1.512) among those using solid fuels for both heating and cooking. Notably, compared to clean fuel users for cooking, solid fuel users for 7 or more years were 1.328 times more likely to develop DSI. We found that the risk of DSI steadily increased with longer duration of solid fuel use (P for trend = 0.008).</p><p><strong>Conclusion: </strong>Household solid fuel use increased the risk of DSI and HI for middle-aged and older Chinese adults, suggesting that reducing household solid fuel use and decreasing household air pollution may help prevent the development of sensory impairments.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"239"},"PeriodicalIF":3.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of population ageing on stroke-related disability-adjusted life years: a global decomposition analysis.","authors":"Yannan Wang, Hexi Wang, Yue Fang","doi":"10.1007/s40520-025-03145-x","DOIUrl":"10.1007/s40520-025-03145-x","url":null,"abstract":"<p><strong>Background: </strong>This study aims to analyze the global impact of population ageing on stroke-related disability-adjusted life years (DALYs) from 1990 to 2021.</p><p><strong>Methods: </strong>Decomposition analysis was conducted using Global Burden of Disease (GBD) data to isolate the contributions of population size, ageing, and age-specific stroke rates to stroke-related DALYs.</p><p><strong>Results: </strong>Population ageing was found to be the dominant driver of stroke-related DALYs globally. From 1990 to 2021, population ageing contributed to an increase of 55.24 million stroke-related DALYs. The greatest impact was observed in Middle-SDI regions, where stroke-related DALYs attributable to population ageing rose significantly. Among the GBD regions, East Asia had the highest contribution to stroke-related DALYs attributed to population ageing for males (100.41%), while High-income Asia Pacific recorded the highest for females (97.49%). In stroke subtypes, ischemic stroke was the most significantly affected by population ageing, while subarachnoid hemorrhage (SAH) was the least affected.</p><p><strong>Conclusions: </strong>Population ageing is a dominant driver of the growing global stroke burden, necessitating targeted public health interventions for ageing populations.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"237"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}