Aging Clinical and Experimental Research最新文献

{"title":"Cross-sectional and longitudinal associations of activity diversity with physical function in community-dwelling older adults","authors":"Daijo Shiratsuchi,&nbsp;Shoma Akaida,&nbsp;Yuto Miyake,&nbsp;Kento Tabira,&nbsp;Ryota Kuratsu,&nbsp;Hiroki Nishi,&nbsp;Shoko Atae,&nbsp;Manami Fukumori,&nbsp;Takanori Iko,&nbsp;Hyuma Makizako","doi":"10.1007/s40520-026-03446-9","DOIUrl":"10.1007/s40520-026-03446-9","url":null,"abstract":"<div><h3>Background</h3><p>The role of activity diversity across physical, cognitive, and social domains in preserving physical function remains unexplored.</p><h3>Aims</h3><p>To investigate the associations between multidomain activity diversity and physical function in community-dwelling older adults.</p><h3>Methods</h3><p>We analyzed data from 763 participants (mean age: 74.8 ± 6.2 years; 63.8% female) in the 2018 Tarumizu Study. Activity diversity was assessed using 12 items (physical, cognitive, and social activities; four per domain). High engagement was defined as participation in ≥ 3 within a domain. Participants were categorized by the number of highly engaged domains (0–1, 2, and 3). Low physical function was defined as low grip strength (&lt; 28 kg for males; &lt;18 kg for females) and/or slow gait speed (&lt; 1.0 m/s). Logistic regression analyses examined cross-sectional (<i>n</i> = 763) and 5-year longitudinal (<i>n</i> = 175 among those without low physical function at baseline) associations.</p><h3>Results</h3><p>Cross-sectionally, low physical function occurred in 45.3%, 29.1%, and 21.4% in the 0–1, 2, and 3 domain groups, respectively. Participants engaged in two or three domains had significantly lower odds of low physical function than those engaged in 0–1 domains. Over 5 years, incident low physical function occurred in 35.1%, 16.2%, and 11.4% of the 0–1, 2, and 3 domain groups, respectively, with significantly lower risks in the 2 and 3 domain groups, and a linear trend (<i>p</i> for trend = 0.023).</p><h3>Discussion</h3><p>Engagement in ≥ 2 activity domains was associated with reduced risk of low physical function in older adults.</p><h3>Conclusions</h3><p>Maintaining diverse lifestyle activities supports physical function in later life.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03446-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain and the aging brain: beyond association toward action","authors":"Kianoush saberi,&nbsp;Nikki Ghadiminia,&nbsp;Roya Yadkar,&nbsp;Arman Abroumand Gholami,&nbsp;Dadabayeva Mukhlisakhon,&nbsp;Radjabov Akhtam,&nbsp;Daminov Feruz,&nbsp;Nasiba Sabirova","doi":"10.1007/s40520-026-03449-6","DOIUrl":"10.1007/s40520-026-03449-6","url":null,"abstract":"<div><p>Chronic pain affects more than half of older adults and has been increasingly linked to cognitive decline, a relationship with profound implications for healthy aging. Ramezani and colleagues examined this association in 1,343 Iranian older adults from the Birjand Longitudinal Aging Study, a well‑characterised cohort from an understudied population. The study has notable strengths: a large sample size, population‑based recruitment, and DAG‑guided covariate selection. However, three methodological limitations warrant consideration. First, pain was measured only once, but longitudinal evidence shows that pain trajectories and multisite chronic pain, not single‑timepoint intensity, drive cognitive decline. Second, adjusting for employment, wealth, and living arrangement without distinguishing confounders from mediators may have introduced overadjustment bias. Third, the composite cognitive definition (failure on all three tests) has never been validated, raising questions about the 59.6% prevalence reported. Future studies should incorporate repeated pain assessments, distinguish single‑site from multisite pain, use careful causal modelling, and validate composite cognitive definitions.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03449-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions, motivations, needs and experiences of geriatricians with regard to research and research consortia","authors":"Julia Minnema,&nbsp;Isabelle S. Moens,&nbsp;Yvonne M. Drewes,&nbsp;Floor J. A. van Deudekom,&nbsp;Jacobijn Gussekloo,&nbsp;Mirella M. N. Minkman,&nbsp;Simon P. Mooijaart,&nbsp;Sarah H. M. Robben,&nbsp;Hanna C. Willems,&nbsp;Hugo P. M. van der Kuy,&nbsp;Francesco Mattace-Raso,&nbsp;Harmke A. Polinder-Bos,&nbsp;Miriam C. Faes","doi":"10.1007/s40520-026-03426-z","DOIUrl":"10.1007/s40520-026-03426-z","url":null,"abstract":"<div><h3>Background</h3><p>With the aging population, there is a growing need for research in geriatrics. Currently, participation of geriatricians in research is behind that of other specialties.</p><h3>Aim</h3><p>We aim to investigate the perceptions, motivations, needs and experiences of geriatricians with regard to research and their willingness to contribute to research consortia in the Netherlands.</p><h3>Methods</h3><p>The study was a sequential explanatory mixed-methods study. Between March 2024 and May 2024, all Dutch geriatricians were invited to participate in an online survey, then semi-structured interviews were conducted. An inductive thematic analysis was used to identify, analyse, and report patterns in the qualitative data.</p><h3>Results</h3><p>171 geriatricians (80.6% female) participated in the survey (31.8% response rate). According to the survey, all geriatricians felt a shared responsibility to participate in research. However, 101/171 (59.1%) geriatricians did not participate. Of the 70 geriatricians that participated in research, 20 (28.6%) joined a research consortium. Following the survey, 21 semi-structured interviews were conducted. Lack of time, financial resources, and inadequate training during geriatric residency were identified as barriers to participate in research. Interviews revealed that earlier positive experiences with research and synergic collaboration with colleagues encourage participation of geriatricians in research.</p><h3>Discussion</h3><p>More focus on research during geriatric medicine residency could foster long-term research involvement. This can be achieved by providing increased exposure to research, positive experiences with research, and access to skilled supervisors.</p><h3>Conclusion</h3><p>Barriers and facilitators should be addressed in policies to promote greater involvement of geriatricians in research and research consortia.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03426-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond hospice: the burden of palliative care needs in hospitals and long-term care facilities. A nationwide multicenter study","authors":"Graziano Onder,&nbsp;Alberto Zucchelli,&nbsp;Alba Malara,&nbsp;Gilda Borselli,&nbsp;Angela Iurlaro,&nbsp;Claudia Bauco,&nbsp;Angelo Bianchetti,&nbsp;Christian Bracco,&nbsp;Carmine Cafariello,&nbsp;Stefania Cartesio,&nbsp;Luca Cipriani,&nbsp;Giulia Deias,&nbsp;Diego De Leo,&nbsp;Elisa Durante,&nbsp;Gianpaolo Fortini,&nbsp;Fabio Gilioli,&nbsp;Stefania Giordano,&nbsp;Guido Horn,&nbsp;Myriam Macaluso,&nbsp;Lorenzo Palleschi,&nbsp;Elena Pinardi,&nbsp;Claudio Santini,&nbsp;Gianlorenzo Scaccabarozzi,&nbsp;Roberto Tarquini,&nbsp;Monica Torrini,&nbsp;Edoardo Varratta,&nbsp;Nicola Veronese,&nbsp;Maria Beatrice Zazzara,&nbsp;Dario Leosco,&nbsp;Giuseppe Bellelli,&nbsp;Palliative Care Day 2025 Working Group","doi":"10.1007/s40520-026-03445-w","DOIUrl":"10.1007/s40520-026-03445-w","url":null,"abstract":"<div><h3>Introduction</h3><p>Palliative care is traditionally associated with hospice and cancer care, yet older adults admitted to hospitals and long-term care facilities (LTCF) frequently experience multimorbidity, frailty, and high symptom burden. We aimed to estimate the prevalence and characteristics of palliative care needs in Internal Medicine and Geriatrics hospital wards and LTCF in Italy.</p><h3>Methods</h3><p>We conducted a national cross-sectional point-prevalence study. Adults aged ≥ 18 years hospitalized in participating wards or residing in LTCF were eligible. NECPAL 4.0 tool was used to identify patients and residents with palliative care needs. Additional indicators included functional and nutritional decline, repeated hospitalizations, dysphagia, pressure ulcers, delirium, and pain.</p><h3>Results</h3><p>A total of 5,389 participants were included (3,303 hospital patients, median age 81 years; 2,086 LTCF residents, median age 86 years) from 235 facilities. Overall, 58.3% of hospitalized patients and 48.1% of LTCF residents had a positive NECPAL assessment. Prevalence was higher among patients with cancer (77.2% in hospital; 61.5% in LTCF), but remained substantial among those without cancer (50.8% in hospital; 46.8% in LTCF). Functional decline (56.2% hospital; 48.7% LTCF), nutritional decline (36.6%; 23.9%), dysphagia (17.6%; 28.8%), delirium (19.2%; 36.4%), and moderate-to-severe pain (25.9%; 20.3%) were common across settings.</p><h3>Conclusion</h3><p>Palliative care needs are highly prevalent among hospitalized patients and LTCF residents and are not limited to oncology. These findings support systematic screening and integration of a needs-based palliative care approach within hospital and long-term care systems.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03445-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of spiritual transcendence and kinesiophobia on successful aging in older adults","authors":"Fatoş Uncu,&nbsp;Hasan Evci̇men,&nbsp;Metin Yildiz,&nbsp;Muhammed Ali Aydin,&nbsp;Eren Polat","doi":"10.1007/s40520-026-03414-3","DOIUrl":"10.1007/s40520-026-03414-3","url":null,"abstract":"<div><h3>Background</h3><p>With the aging population increasing, it is important to identify effective psychological and spiritual support factors to help individuals experience the aging process in a healthier and more meaningful way. This study aims to examine the effect of spiritual transcendence and kinesiophobia on successful aging.</p><h3>Methods</h3><p>A quantitative cross-sectional descriptive survey method was used in this research. The study was conducted between February and July 2025 with 871 elderly individuals. Hierarchical regression analysis was performed using SPSS 25.0. Machine learning analysis and estimation were performed using the R programming language version 4.1.3.</p><h3>Results</h3><p>The mean age of the participants was 70.75 ± 5.40. According to regression analysis, the level of spiritual transcendence explains 51.9% of the level of successful aging (R²=0.519), and this relationship was found to be statistically significant (t = 30.619, p&lt;0.001). When spiritual transcendence and kinesiophobia levels were evaluated together, the explained variance ratio reached 67.5% (R²=0.675). An increase in spiritual transcendence (t = 14.122, p&lt;0.001) and a decrease in kinesiophobia (t=–20.418, p&lt;0.001) show a statistically significant relationship with the level of successful aging. SHAP values show the extent to which each variable influences the model’s predictions and the magnitude of this influence. According to these values, kinesiophobia is identified as the most important variable in predicting the successful aging variable.</p><h3>Conclusions</h3><p>The findings from our study indicate that supporting the psychological and spiritual resources of older adults plays an important role in strengthening the successful aging process. Longitudinal studies on successful aging are recommended.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13572338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediagnosis frailty and survival after cancer in middle-aged and older adults: a population-based cohort study","authors":"Guangzhi Wan,&nbsp;Chunyan Ma,&nbsp;Chunqiao Ma,&nbsp;Jingzhi Guan","doi":"10.1007/s40520-026-03440-1","DOIUrl":"10.1007/s40520-026-03440-1","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Frailty is a multidimensional syndrome reflecting diminished physiological reserve and has been associated with adverse outcomes in middle-aged and older adults with cancer. However, its long-term prognostic significance when assessed prior to cancer diagnosis remains insufficiently characterized.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;We conducted a population-based prospective cohort study using data from the 2006 wave of the Health and Retirement Study (HRS), with follow-up through December 31, 2020. Participants were middle-aged and older adults aged 52 years or older, were cancer-free at baseline, and subsequently developed incident cancer. Frailty was assessed a median of 6.0 years before diagnosis using a 33-item deficit accumulation frailty index (FI) and categorized as non-frail (≤ 0.10), pre-frail (&gt; 0.10 to ≤ 0.21), and frail (&gt; 0.21). The primary outcome was all-cause mortality after cancer diagnosis. Weighted Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for age, sex, race/ethnicity, education, residential setting, smoking status, alcohol consumption, hypertension, diabetes, chronic obstructive pulmonary disease, heart disease, psychiatric disorders, rheumatic disease, and persistent pain.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Among 1,882 participants, 819 deaths occurred over a median follow-up of 8.7 years after diagnosis. In the fully adjusted model, both pre-frailty and frailty were independently associated with higher mortality compared with non-frailty (HR 1.35, 95% CI 1.05–1.73; and HR 1.87, 95% CI 1.34–2.59, respectively). When modeled continuously, each 0.01-unit increase in FI was associated with an approximately 2% higher mortality risk (HR 1.02, 95% CI 1.01–1.03). At baseline, 740 participants (39.3%) were younger than 65 years, whereas 1,142 participants (60.7%) were aged 65 years or older. Age-stratified fully adjusted weighted Cox analyses demonstrated that each 0.01-unit increment in FI was associated with elevated mortality in the total population (HR 1.022, 95% CI 1.015–1.030; &lt;i&gt;P&lt;/i&gt; &lt; 0.001), adults aged ≥ 65 years (HR 1.017, 95% CI 1.008–1.026; &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and participants &lt; 65 years (HR 1.023, 95% CI 1.011–1.036; &lt;i&gt;P&lt;/i&gt; = 0.003). Significant nonlinear associations were observed for the total population and those aged ≥ 65 years (both P-nonlinear &lt; 0.001), whereas nonlinearity was not statistically significant among participants &lt; 65 years (P-nonlinear = 0.124; Fig. 3, Supplementary Table S10).&lt;/p&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;These findings suggest that prediagnosis frailty may serve as a marker of underlying vulnerability and may provide modest incremental prognostic information for longitudinal risk assessment in geriatric oncology. Future interventional studies are needed to test whether frailty-targeted assessment and management before or after cancer diagnosis can improve survival, functional outcomes, or quality of ","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building healthier communities: effectiveness and cost-sustainability of the ASL3 GENESIS program for chronic diseases prevention","authors":"Luigi C. Bottaro,&nbsp;Enrico Torre,&nbsp;Andrea Giusti,&nbsp;Marta Caltabellotta,&nbsp;Isabella Cevasco,&nbsp;Dario Camellino,&nbsp;Gianni Testino,&nbsp;Simona Bottino,&nbsp;Sergio Di Matteo,&nbsp;Stefano Grego,&nbsp;Luca Degli Esposti","doi":"10.1007/s40520-026-03429-w","DOIUrl":"10.1007/s40520-026-03429-w","url":null,"abstract":"<div><h3>Background</h3><p>Population aging leads to rising chronic disease burden and healthcare costs. The metropolitan area of Genoa (Liguria), the oldest in Italy, is particularly affected. Since 2017, ASL3 has implemented a comprehensive health promotion strategy including risk-factor reduction initiatives and multidisciplinary care pathways for multimorbid patients.</p><h3>Aims</h3><p>To evaluate the impact of the comprehensive health promotion program on the prevalence of heart failure (HF), chronic kidney disease (CKD), and chronic liver disease (CLD), and on healthcare resource use.</p><h3>Methods</h3><p>Using the ASL3 data warehouse, we analyzed trends in HF, CKD, and CLD prevalence from 2011 to 2023 and compared yearly prevalence between 2011 and 2019 and 2020–2023. Hospitalization, outpatient activity and drug-prescription data were assessed; production and pharmaceutical costs were calculated. Regression models evaluated changes in prevalence trajectories.</p><h3>Results</h3><p>The resident population and average age increased slightly (from 704,355 to 711,133 people; from 49 to 51 years old). The unadjusted and standardized prevalence of HF, CKD and CLD rose significantly over the study period. However, after regression analysis, significance was confirmed only for the period 2011–2019. In 2020–2023, prevalence continued to rise, but at a substantially slower rate, suggesting an attenuation of the upward trend.</p><h3>Conclusions</h3><p>A multifaceted, system-wide prevention and care model may attenuate the upward trend in chronic-disease prevalence in highly aged populations. These findings support integrated health-promotion strategies as a sustainable approach to chronic disease management and resource stewardship.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03429-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-head comparison of neurodegeneration biomarkers across two analytical platforms in Alzheimer’s disease","authors":"Carolin Kurz,&nbsp;Daniela Hattenkofer,&nbsp;Maximilian Pihale-Haug,&nbsp;Anna Hufnagel,&nbsp;Selim Üstün Gürsel,&nbsp;Matthias Brendel,&nbsp;Boris-Stephan Rauchmann,&nbsp;Johannes Levin,&nbsp;Günter Höglinger,&nbsp;Robert Perneczky","doi":"10.1007/s40520-026-03420-5","DOIUrl":"10.1007/s40520-026-03420-5","url":null,"abstract":"<div><h3>Background</h3><p>Blood-based biomarkers are increasingly used to support the identification of Alzheimer’s disease (AD) in clinical and research settings. However, variability between analytical platforms limits their interchangeability and may affect their clinical interpretation. Direct head-to-head comparisons across assays and their alignment with clinical phenotypes remain limited.</p><h3>Objective</h3><p>To compare the inter-test agreement of blood-based biomarkers measured using Roche and Fujirebio assays and to determine which biomarker shows the most robust analytical concordance and clinical relevance in AD.</p><h3>Methods</h3><p>Participants with AD (n = 86) and cognitively healthy controls (HC; n = 56) underwent blood biomarker assessment using Roche and Fujirebio platforms. Plasma phosphorylated tau at threonine 217 (pTau217), plasma phosphorylated tau at threonine 181 (pTau181), Amyloid-β42 (Aβ42), amyloid-β40 (Aβ40), and the amyloid-β42/amyloid-β40 ratio (Aβ42/Aβ40) and glial fibrillary acidic protein (GFAP) were analyzed. Inter-test agreement was assessed using intraclass correlation coefficients, concordance analyses, and regression-based methods. Clinical relevance was evaluated by association with measures of cognitive and functional impairment evaluated using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB). Analyses were adjusted for age and sex and complemented by sensitivity and stability analyses.</p><h3>Results</h3><p>Inter-test agreement varied across biomarkers, with pTau217 demonstrating the highest and most stable concordance between Roche and Fujirebio assays. Among the evaluated markers, pTau217 also showed the strongest and most consistent associations with global cognition measures across diagnostic groups and best discriminated between individuals with AD and HC. GFAP demonstrated robust inter-test agreement but weaker alignment with clinical measures, while amyloid-based markers showed lower concordance and greater variability across platforms.</p><h3>Conclusions</h3><p>Head-to-head comparison of Roche and Fujirebio assays revealed biomarker-specific differences in inter-test agreement, limiting the direct interchangeability of measurements across platforms. Plasma pTau217 showed the most consistent analytical concordance and clinical associations in this setting, supporting its potential utility in cross-platform applications. However, these findings also highlight the need for assay-specific calibration and cautious interpretation of biomarker thresholds in clinical and research use and the need for further validation across diverse populations.</p><h3>Trial registration</h3><p>NCT05059158, NCT05317871</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03420-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the regular physical exercise adherence scale (REPEAS) in Brazilian older adults","authors":"Leiane Mota Costa,&nbsp;Aldair Darlan Santos-de-Araújo,&nbsp;Victória Pereira Frutuoso,&nbsp;Fabio Henrique Ferreira Pereira,&nbsp;Marinete Rodrigues de Farias Diniz,&nbsp;Abraão Albino Mendes Júnior,&nbsp;Almir Vieira Dibai-Filho,&nbsp;Daniela Bassi-Dibai","doi":"10.1007/s40520-026-03441-0","DOIUrl":"10.1007/s40520-026-03441-0","url":null,"abstract":"<div><h3>Background</h3><p>The objective of this cross-sectional observational study was to validate a scale that highlights the personal and environmental barriers that hinder adherence to regular physical exercise in older adults.</p><h3>Methods</h3><p>Individuals aged 60 years or over, sedentary and/or ex-practitioners, regular practitioners of physical exercise, with Brazilian Portuguese as their mother tongue. In addition to the Regular Physical Exercise Adherence Scale (REPEAS), the following instruments were applied: sociodemographic data sheet and Baecke Habitual Physical Activity Questionnaire. The measurement properties tested were: structural validity, construct validity, reliability, consistency internal and ceiling and floor effects.</p><h3>Results</h3><p>This research involved 200 older adults’ participants, predominantly women. The confirmatory factor analysis supported the two-domain, 12-item structure of the REPEAS, demonstrating good model fit with the following indices: chi-square/degrees of freedom = 1.60, comparative fit index = 0.965, Tucker-Lewis index = 0.957, root mean square error of approximation = 0.078, and standardized root mean square residual = 0.078. Construct validity was evidenced by a statistically significant difference (<i>p</i> &lt; 0.05) in the personal factors domain between groups. Additionally, the domains of the REPEAS showed appropriate correlations with the items in the factor analysis. Reliability was acceptable, with composite reliability ≥ 0.84 and intraclass correlation coefficient ≥ 0.89.</p><h3>Conclusion</h3><p>This scale presented adequate measurement properties when tested on Brazilian older adults to assess environmental and personal barriers to regular physical exercise. However, as this was a study conducted with a convenience sample, generalization of the findings should be made with caution. Despite this, the REPEAS can serve as a practical tool for health professionals and researchers to identify modifiable barriers and guide strategies to promote physical activity among older adults.</p><h3>Trial registration</h3><p>Not applicable.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03441-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old","authors":"Konstantinos Prokopidis,&nbsp;Hanne Nygaard,&nbsp;Rikke S Kamper,&nbsp;Pernille Hansen,&nbsp;Sofie K Hansen,&nbsp;Eckart Pressel,&nbsp;Jens Rasmussen,&nbsp;Charlotte Suetta","doi":"10.1007/s40520-026-03442-z","DOIUrl":"10.1007/s40520-026-03442-z","url":null,"abstract":"<div><h3>Background</h3><p>Hospital-associated deconditioning is a contributor to secondary sarcopenia, which may be driven by prolonged hospital length of stay (LoS). This study investigated the bidirectional association of LoS and sarcopenia indices (lean soft tissue, muscle strength, physical function) in older inpatients, with a focus on age- and sex-specific differences.</p><h3>Methods</h3><p>Using cross-sectional data from the Copenhagen PROTECT study, 1071 older inpatients (aged ≥ 65 years) were included. Appendicular lean soft tissue index (ALSTI), handgrip strength (HGS), gait speed, and 30-second chair stand test (30CST) were assessed within 24 h of admission and sarcopenia was defined per the EWGSOP2 criteria. Linear and logistic regressions examined associations between LoS and sarcopenia indices, stratified by age and sex.</p><h3>Results</h3><p>In patients ≥ 80 years, longer LoS (based on the cohort’s median) was associated with lower gait speed and 30CST in both sexes (<i>p</i> &lt; 0.01), and lower HGS in women (<i>p</i> = 0.03). In men &lt; 80 years, longer LoS correlated with lower HGS and 30CST (<i>p</i> &lt; 0.01), with higher odds of sarcopenia (Low ALSTI and low 30CST; OR = 3.14, <i>p</i> = 0.03). Higher 30CST and HGS were consistently associated with shorter LoS, particularly in men ≥ 80 years and women across both age groups.</p><h3>Conclusions</h3><p>HGS and 30CST are strongly associated with LoS in older inpatients, with more pronounced effects in those ≥ 80 years. Future longitudinal studies and trials are warranted to confirm causality, that may guide rehabilitation strategies to reduce LoS through targeted interventions.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03442-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}