Aging Clinical and Experimental Research最新文献

{"title":"Comparison of surgical and radiotherapy outcomes in octogenarians with early-stage non-small cell lung cancer: a SEER database retrospective cohort study","authors":"Wenxuan Hua,&nbsp;Zhigang Zhang,&nbsp;Lianfang Ni,&nbsp;Xinmin Liu","doi":"10.1007/s40520-025-02948-2","DOIUrl":"10.1007/s40520-025-02948-2","url":null,"abstract":"<div><h3>Background</h3><p>Lung cancer remains the leading cause of death worldwide, yet optimal treatment strategies for octogenarians with early-stage non-small cell lung cancer (NSCLC) remain unclear.</p><h3>Aims</h3><p>To investigate treatment patterns and survival outcomes in octogenarians and older with early-stage NSCLC.</p><h3>Methods</h3><p>A retrospective cohort study was conducted using Surveillance, Epidemiology, and End Results database. Patients aged ≥ 80 years with stage I–IIA NSCLC diagnosed between 2011 and 2020 were included. Primary treatments included surgery, radiation, and no treatment. Kaplan–Meier curves were used to evaluate overall survival (OS) and cancer-specific survival (CSS) stratified by treatment and year. Propensity score matching balanced clinical characteristics between surgery and radiation groups, followed by Cox regression analysis. Survival outcomes were further compared within matched subgroups stratified by tumor size.</p><h3>Results</h3><p>Among 7,372 patients, median survival was 67 months for surgery and 33 months for radiotherapy. Radiotherapy use increased from 31.2% in 2011 to 49.4% in 2020, while surgery rates declined. Multivariate analysis (<i>N</i> = 2,434) showed radiotherapy was associated with worse OS (hazard ratio = 1.96, 95% CI = 1.78–2.15, <i>P</i> &lt; 0.001) compared to surgery.</p><h3>Discussion</h3><p>Radiotherapy is increasingly used to treat early-stage NSCLC in octogenarians, yet surgery provides superior long-term survival. Limitations of lack of detailed comorbidity data and differentiation between conventional radiotherapy and stereotactic ablative radiotherapy (SABR) may have expanded the advantages of surgery. Meanwhile, patient performance status and preferences must be considered in treatment decisions.</p><h3>Conclusions</h3><p>Surgery remains the preferred treatment option for eligible octogenarians with early-stage NSCLC.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02948-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year atherosclerotic cardiovascular disease risk score in post-menopausal women with low bone mineral density","authors":"Kaiser Wani,&nbsp;Shaun Sabico,&nbsp;Nicola Veronese,&nbsp;Abeer A. Al-Masri,&nbsp;Nasser M. Al-Daghri","doi":"10.1007/s40520-025-02957-1","DOIUrl":"10.1007/s40520-025-02957-1","url":null,"abstract":"<div><h3>Background</h3><p>Reports on the association between cardiovascular disease (CVD) risk and bone mineral density (BMD) remain inconsistent and hence more population-based studies on this subject are needed.</p><h3>Aims</h3><p>This cross-sectional study aimed to evaluate the association between bone mineral density (BMD) at the lumbar spine (L1-L4) and femoral neck (right and left) with 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores in Saudi postmenopausal women.</p><h3>Methods</h3><p>A cohort of 1,450 postmenopausal women with risk factors for bone loss were analyzed using the data from the Chair for Biomarkers of Chronic Diseases (CBCD) Osteoporosis database. BMD at the lumbar spine and femoral neck was assessed using dual-energy X-ray absorptiometry (DXA). Anthropometric and biochemical parameters, including fasting glucose and lipid profiles, were measured. ASCVD risk scores were calculated using the ASCVD Risk Estimator Plus tool. BMD tertiles were analyzed for their association with ASCVD risk.</p><h3>Results</h3><p>Women with osteoporosis had significantly lower BMI, waist and hip circumferences, and metabolic dysfunction markers compared to those with normal BMD. Significant negative correlations were observed between ASCVD risk scores and BMD at femoral neck sites in women with osteopenia and osteoporosis. Multivariate logistic regression indicated that women in the lowest BMD tertiles had significantly higher odds of intermediate to high ASCVD risk scores, with adjusted odds ratios of 1.90 for the lumbar spine, 2.19 for the right femoral neck, and 2.04 for the left femoral neck.</p><h3>Conclusions</h3><p>The study identified significant associations between lower BMD at the lumbar spine and femoral neck sites and elevated 10-year ASCVD risk scores in postmenopausal women, particularly among those with osteopenia and osteoporosis. These findings demonstrate the importance of assessing cardiovascular risk in women with low BMD to enable early prevention and management strategies.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02957-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between inflammatory markers, walking speed, and metabolic syndrome in older Chinese adults","authors":"Dabing Dai,&nbsp;Lican Zhao,&nbsp;Shuai Li,&nbsp;Yu Xu,&nbsp;Aiping Du","doi":"10.1007/s40520-025-02984-y","DOIUrl":"10.1007/s40520-025-02984-y","url":null,"abstract":"<div><h3>Objective</h3><p>As China’s ageing process accelerates, the annual prevalence of Metabolic Syndrome (MetS) among older Chinese adults continues to rise. This study seeks to assess the relationship between inflammatory markers, walking pace, and MetS in old Chinese adults.</p><h3>Methods</h3><p>This study utilised a cross-sectional design, drawing on data from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS) conducted by Peking University, encompassing 3587 older adults aged over 60. Data regarding inflammatory markers (CRP), walking speed, and variables associated with MetS (including waist circumference and blood pressure) were gathered. Multiple linear regression analysis was used to evaluate the relationship between CRP, walking speed, and MetS.</p><h3>Results</h3><p>In a cohort of 3587 older Chinese adults, slower walking speed (β = 0.414) and elevated CRP levels (β = 0.209) were significantly correlated with MetS, with the association persisting after controlling for confounding variables. Furthermore, females, urban residents, individuals with a higher BMI, and smokers exhibited an increased risk of developing MetS.</p><h3>Conclusion</h3><p>Walking speed and CRP levels are critical determinants in evaluating the risk of MetS in older adults; improving walking speed and mitigating inflammation may contribute to a decreased risk of MetS.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02984-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study","authors":"Yuxuan Zhan,&nbsp;Zhiyun Zhang,&nbsp;Siyi Lin,&nbsp;Bang Du,&nbsp;Kai Zhang,&nbsp;Jian Wu,&nbsp;Hongxia Xu","doi":"10.1007/s40520-025-02977-x","DOIUrl":"10.1007/s40520-025-02977-x","url":null,"abstract":"<div><h3>Background</h3><p>Patients with sarcopenia often experience cognitive decline, affecting cortical structures, but the causal link remains unclear. We used bidirectional Mendelian randomization (MR) to explore the relationship between sarcopenia-related traits and cortical structure.</p><h3>Methods</h3><p>We selected genetic variables from genome-wide association study data. Three different MR methods were used: inverse-variance weighted analysis, MR-Egger regression, and the weighted median test. For significant estimates, we further conducted Cochran’s Q test, MR-Egger intercept test, leave-one-out analyses, and MR-PRESSO to assess heterogeneity.</p><h3>Results</h3><p>In forward MR analysis, appendicular lean mass (ALM) decreased the thickness (TH) of lateral occipital gyrus and increased the TH of pars opercularis gyrus (β = -0.0079 mm, 95% CI: -0.0117 mm to -0.0041 mm, <i>P</i> &lt; 0.0001; β = 0.0080 mm, 95% CI: 0.0042 mm to 0.0117 mm, <i>P</i> &lt; 0.0001). In reverse MR analysis, a significant negative correlation was found between the TH of bankssts and ALM, while positive correlations were observed between the TH of frontal pole, rostral anterior cingulate, temporal pole, and ALM. The TH of temporal pole was positively correlated with right hand grip strength (HGS-R) (β = 0.1596 mm, 95% CI: 0.1349 mm to 0.1843 mm, <i>P</i> &lt; 0.0001), and the TH of pars triangularis was positively correlated with left-hand grip strength (HGS-L) (β = 0.3251 mm, 95% CI: 0.2339 mm to 0.4163 mm, <i>P</i> &lt; 0.0001).</p><h3>Conclusions</h3><p>Sarcopenia-related traits and cortical structure have bidirectional effects, supporting the muscle-brain axis theory. This links sarcopenia to neurocognitive diseases and provides new strategies for the prevention and intervention of both sarcopenia and cognitive decline.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02977-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study","authors":"Shan Ding,&nbsp;Fengling Yang,&nbsp;Pan Lai,&nbsp;Jiang Weiwen,&nbsp;Minze Chen,&nbsp;Yijun Ge,&nbsp;Liting Zhou,&nbsp;Shaozhuang Chen,&nbsp;Jiaqi Zhang,&nbsp;Ye Yanrong","doi":"10.1007/s40520-024-02900-w","DOIUrl":"10.1007/s40520-024-02900-w","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02900-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty as an independent risk factor for sepsis-associated delirium: a cohort study of 11,740 older adult ICU patients","authors":"Guoqiang Zheng,&nbsp;Jiajian Yan,&nbsp;Wanyue Li,&nbsp;Zhuoming Chen","doi":"10.1007/s40520-025-02956-2","DOIUrl":"10.1007/s40520-025-02956-2","url":null,"abstract":"<div><h3>Background</h3><p>Sepsis-associated delirium (SAD) is a common complication in intensive care unit (ICU) patients and is associated with increased mortality. Frailty, characterized by diminished physiological reserves, may influence the development of SAD, but this relationship remains poorly understood.</p><h3>Aims</h3><p>To comprehensively analyze the assessment of frailty as a predictive factor for sepsis-associated delirium in older adults.</p><h3>Methods</h3><p>A retrospective cohort analysis was performed on sepsis patients aged ≥ 65 years admitted to the ICU. Frailty was assessed using the Modified Frailty Index based on 11 items including comorbidities and functional status. Patients were categorized into non-frail (MFI: 0–2) and frail (MFI ≥ 3) groups. Delirium was assessed using the ICU Confusion Assessment Method (CAM-ICU) and retrospective nursing notes. Logistic regression analysis was used to examine the relationship between frailty in older patients and the risk of delirium, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated.</p><h3>Results</h3><p>Among 11,740 patients (median age approximately 76 years [interquartile range: 70.47–83.14], 44.3% female), frail patients tended to have longer ICU stays, higher severity scores, and potentially worse clinical outcomes. The study found a significant positive association between MFI and the risk of developing SAD (OR: 1.13, 95% CI: 1.09–1.17, <i>p</i> &lt; 0.001). Additionally, frail patients had a higher risk of developing SAD compared to non-frail patients (OR: 1.31, 95% CI: 1.20–1.43, <i>p</i> &lt; 0.001).</p><h3>Conclusions</h3><p>Frailty independently predicts SAD development in older adults with sepsis in the ICU, emphasizing the importance of early recognition and prevention.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02956-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary 4-pyridoxic acid as a non-invasive biomarker for evaluating osteoarthritis severity: findings from the ROAD study","authors":"Noriko Yoshimura,&nbsp;Aiko Miyazaki,&nbsp;Toshiko Iidaka,&nbsp;Nobuo Ando,&nbsp;Gaku Tanegashima,&nbsp;Shigeyuki Muraki,&nbsp;Horiyuki Oka,&nbsp;Sakae Tanaka","doi":"10.1007/s40520-025-02944-6","DOIUrl":"10.1007/s40520-025-02944-6","url":null,"abstract":"<div><h3>Background</h3><p>The early detection of osteoarthritis (OA) requires reliable biomarkers; however, reports identifying such biomarkers remain limited.</p><h3>Aims</h3><p>This study aimed to evaluate the potential of urinary 4-pyridoxic acid (4PA) as a biomarker for the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS) in Japanese adults, using data from the population-based cohort study.</p><h3>Methods</h3><p>Data were analysed from 1566 participants (510 men and 1,056 women) aged ≥ 40 years, who were enrolled in the Research on Osteoarthritis/Osteoporosis against Disability (ROAD) cohort, a population-based study initiated in 2005. Participants underwent radiographic assessments of the knees and lumbar spine, and urinary 4PA levels were measured using high-performance liquid chromatography. Logistic regression analyses were performed to evaluate the association between urinary 4PA levels and the Kellgren–Lawrence (KL) grade of KOA and LS, adjusting for age, sex, body mass index (BMI), and lifestyle factors.</p><h3>Results</h3><p>Urinary 4PA levels were significantly higher in participants with KL grade 4 KOA compared to those with lower KL grades (p &lt; 0.001). This association remained significant after adjusting for confounding factors. In contrast, no significant differences in 4PA levels were observed across the KL grades for LS, although a slight increase in 4PA levels was noted in KL grade 4 cases.</p><h3>Discussion and conclusions</h3><p>These findings suggest that urinary 4PA could serve as a biomarker for assessing KOA severity, particularly in advanced stages. While the detection of early OA using 4PA remains challenging, the significant increase in KL grade 4 cases highlights its potential role in guiding treatment decisions, such as surgical intervention.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02944-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health beliefs mediates the association between the number of non-communicable diseases and preventive behaviors in middle-aged and older adults in southern China","authors":"Yali Huang,&nbsp;Tingjun Wang,&nbsp;Huajun Wang,&nbsp;Yongjun Zeng,&nbsp;Liangdi Xie","doi":"10.1007/s40520-025-02939-3","DOIUrl":"10.1007/s40520-025-02939-3","url":null,"abstract":"<div><h3>Background</h3><p>The triadic relationship among the number of NCDs, preventive behaviors and health beliefs has not been fully explored, especially the role of health beliefs.</p><h3>Aims</h3><p>To explore the association between the number of NCDs and preventive behaviors, as well as the mediating effect of health beliefs and its dimensions among middle-aged and older adults. Provide scientific evidence for developing targeted behavior intervention.</p><h3>Methods</h3><p>Data from 2095 middle-aged and older adults who completed demographic information, health beliefs and preventive behaviors questionnaire. Mediation analysis was used to explore the association of health beliefs and its dimensions between the number of NCDs and preventive behaviors.</p><h3>Results</h3><p>Health beliefs and self-efficacy positively impacted preventive behaviors, whereas perceived severity, while perceived barriers had negative effects. Health beliefs (<i>β</i> = − 0.1809, 95% CI − 0.2658 to − 0.0960) and its dimensions(Perceived barriers:<i>β</i> = − 0.0881, 95% CI − 0.1533 to − 0.0232, self-efficacy: <i>β</i> = − 0.2706, 95% CI − 0.3592 to − 0.1892) partially mediated the associations between the number of NCDs and preventive behaviors. The negative mediation effects indicates that as the number of NCDs increases, preventive behaviors decrease, partly due to a decline in health beliefs and self-efficacy, as well as an increase in perceived barriers (scored inversely, meaning higher barriers). These mediation pathways exhibited modest strength, highlighting the importance of health beliefs on behavior change.</p><h3>Conclusions</h3><p>An increasing number of NCDs is associated with reduced engagement in preventive behaviors. Health beliefs and its dimensions play a partial mediating role in this relationship. Effective intervention targeting health beliefs may help promote positive behavioral changes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02939-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falls and physical function in older patients with Benign Paroxysmal Positional Vertigo (BPPV): findings from a placebo controlled, double blinded randomized control trial (RCT) investigating efficacy of vitamin D treatment in lowering the recurrence rate of BPPV","authors":"Xiaoting Huang,&nbsp;Kenneth Wei De Chua,&nbsp;Shirlene Pei Shi Moh,&nbsp;Heng Wai Yuen,&nbsp;David Yong Ming Low,&nbsp;Poongkulali Anaikatti,&nbsp;Arshad Iqbal,&nbsp;Barbara Helen Rosario","doi":"10.1007/s40520-025-02938-4","DOIUrl":"10.1007/s40520-025-02938-4","url":null,"abstract":"<div><h3>Background</h3><p>Benign Paroxysmal Positional Vertigo (BPPV) is the commonest cause of vertigo in older adults. Due to its high incidence in older adults presenting with falls, vestibular assessment is recommended in the World Guidelines for Falls Prevention. There is a paucity of evidence in well conducted randomised controlled trials (RCTs) to evaluate vitamin D for prevention of BPPV recurrence in relation to falls and function.</p><h3>Aims</h3><p>Primary outcome: does vitamin D supplementation and dietary interventions in combination with standard care impact falls, fear of falling and function in patients with BPPV.</p><h3>Methods</h3><p>Post hoc analyses of phase IIa single centre, placebo controlled, double blind RCT evaluating vitamin D supplementation with diet and Canalith Repositioning Procedure (CRP) [Group A] versus diet alone with CRP [Group B] in reducing BPPV recurrence rates and the consequent effects on falls and function.</p><h3>Results</h3><p>53 participants were recruited. 14 were vitamin D replete at baseline (Group C) with remaining 39 randomised into Groups A and B. Group A had better 5x sit to stand time and 0.75 fewer clinical BPPV recurrences per one person year (<i>P</i> = 0.035) compared to Group B. 25% of participants who fell reported fear of falling compared to 43% in those without falls in the 12 month follow up.</p><h3>Discussion</h3><p>Vitamin D supplementation alongside standard BPPV improved 5xchair stand test and reduced BPPV recurrence. Participants without an incident fall during follow up experience fear of falling, prompting further consideration.</p><h3>Conclusion</h3><p>Vitamin D replacement was associated with fewer BPPV recurrences and improved function assessed with 5x chair stand test.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02938-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of postmenopausal osteoporosis with recombinant human parathyroid hormone and electromagnetic field","authors":"Miao Xuan,&nbsp;Bo Wang,&nbsp;Wanrong Bi,&nbsp;Ying Li,&nbsp;Lige Song,&nbsp;Zhuangli Xie,&nbsp;Qi Liu,&nbsp;Xiuzhen Zhang","doi":"10.1007/s40520-025-02932-w","DOIUrl":"10.1007/s40520-025-02932-w","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the effect of electromagnetic field (EMF) combined with recombinant human parathyroid hormone (rhPTH) on bone mineral density (BMD) and bone turnover indicators in postmenopausal osteoporosis (PMOP) patients.</p><h3>Methods</h3><p>A total of 336 PMOP patients were randomly assigned into three groups: EMF + rhPTH group (<i>n</i> = 115), rhPTHx group (<i>n</i> = 113) and EMF group (<i>n</i> = 108). The lumbar spine and femoral neck BMDs were measured before treatment and at 6, 12, and 18 months after treatment. Blood calcium, bone alkaline phosphatase (BSAP), type I procollagen N-terminal peptide (PINP), and type I collagen C-terminal peptide/creatinine ratio (CTX/Cr) levels were measured before treatment and at 3, 6, 12, and 18 months after treatment.</p><h3>Results</h3><p>The lumbar spine BMD was significantly increased at 6, 12, and 18 months after treatment, and the neck BMD was increased markedly at 18 months in both EMF + rhPTH group and rhPTH group as compared to those before treatment. There was significant difference in the lumbar spine BMD between EMF + rhPTH group and EMF group and between rhPTH group and EMF group at 6, 12, and 18 months after treatment. In the EMF + rhPTH group, at 3, 6, 12, and 18 months after treatment, blood calcium level was increased by 5.2%, 2.8%, 2.7%, and 3.1%, respectively; BASP level was increased by 80.9%, 120.3%, 84.1%, and 67.7%, respectively; PINP level was increased by 65.4%, 79.7%, 89.7%, and 74.5%, respectively; CTX/Cr was increased by 80.9%, 120.3%, 84.1%, and 67.7%, respectively; the bone metabolism indicators were markedly higher than those before treatment. In the rhPTH group, at 3, 6, 12, and 18 months after treatment, blood calcium level was increased by 5.1%, 3.3%, 3.0%, and 2.1%, respectively; BSAP level was increased by 51.6%, 81.4%, 101.1% and 56.3% respectively; PINP level was increased by 48.5%, 69.8%, 80.7% and 70.5% respectively; CTX/Cr was increased by 29.8%, 29.9%, 55.7%, and 44.8% respectively; the bone turnover indicators were significantly different from those before treatment (<i>P</i> &lt; 0.01).</p><h3>Conclusion</h3><p>The combination of EMF and rhPTH can significantly improve the bone turnover and BMD of PMOP patients, and may serve as a clinical treatment of PMOP.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02932-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}