Aging Clinical and Experimental Research最新文献

{"title":"Social Interaction as a vital factor in alleviating depressive symptoms among middle-aged and elderly adults: evidence from the CHARLS","authors":"Chao Wang,&nbsp;Zhipeng Huang,&nbsp;Zuxun Lu,&nbsp;Peigang Wang","doi":"10.1007/s40520-025-02941-9","DOIUrl":"10.1007/s40520-025-02941-9","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the effect of social interaction on depressive symptoms in middle-aged and elderly adults in China.</p><h3>Methods</h3><p>Data from the 2020 China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Participants were divided into social interaction and non-social interaction groups. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CESD-10). Propensity score matching (PSM) was employed to balance confounding factors, and the average treatment effect (ATT) of social interaction on depressive symptoms was estimated. Binary logistic regression analyzed influencing factors.</p><h3>Results</h3><p>A total of 14,741 subjects (76.26%) were included; 9,869 (66.91%) participated in social interaction, and 5,593 (37.94%) had depressive symptoms. After PSM, social interaction significantly negatively affected depressive symptoms (ATT=-0.04, <i>P</i> &lt; 0.05). Binary logistic regression revealed that those with social interaction had a lower risk of depressive symptoms (OR = 0.87, <i>P</i> &lt; 0.05), particularly males (OR = 0.53, <i>P</i> &lt; 0.05). However, older age (60–69: OR = 1.20; 70–79: OR = 1.24), poorer self-rated health (general: OR = 2.20; poor: OR = 4.48; very poor: OR = 7.70), lower satisfaction (general: OR = 1.67; dissatisfaction: OR = 8.10), and infrequent meetings with children (every six months: OR = 1.20; less than half a year: OR = 1.27) were associated with a higher risk of depressive symptoms (<i>P</i> &lt; 0.05).</p><h3>Conclusion</h3><p>Middle-aged and elderly Chinese adults have a high risk of depressive symptoms, and social interaction significantly reduces this risk. Promoting social interaction and mental health initiatives can improve the health of middle-aged and elderly individuals.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02941-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis","authors":"Hui Yu,&nbsp;Junxiang Wang,&nbsp;Xin Xu,&nbsp;Hui Li,&nbsp;Junfei Guo","doi":"10.1007/s40520-025-03035-2","DOIUrl":"10.1007/s40520-025-03035-2","url":null,"abstract":"<div><h3>Background</h3><p>Despite well-documented associations between Body mass index (BMI) and Osteoarthritis (OA), the specific biological pathways and mediators involved remain poorly understood. This study aims to explore mediators through which BMI influences OA risk, particularly knee osteoarthritis (KOA), using Mendelian Randomization (MR) and mediation analysis.</p><h3>Methods</h3><p>We used a two-step MR approach with data from the IEU OpenGWAS and FinnGen version 7 databases. BMI (<i>N</i> = 322,154) was the primary exposure, with knee disorders (KD), total bone mineral density (TBMD), metabolic disorders (MD), and anxiety disorders (AD) as potential mediators. Outcomes included KOA (<i>N</i> = 22,347), hip OA (HOA) (<i>N</i> = 11,989), and all OA (AllOA) (<i>N</i> = 50,508). Univariate MR evaluated causal relationships, followed by multivariate MR to quantify mediation effects. Multiple sensitivity analyses were conducted to validate robustness, while horizontal pleiotropy and heterogeneity were assessed using MR-Egger intercept and Cochran’s Q statistic.</p><h3>Results</h3><p>BMI significantly increased the risk of KOA (odds ratio [OR]: 2.00, 95% confidence interval [CI]: 1.56–2.56), HOA (OR: 2.05, 95% CI: 1.40–2.98), and AllOA (OR: 1.66, 95% CI: 1.41–1.95). KD and TBMD significantly mediated the effect on KOA, with mediation proportions of 20.89% and 3.59%, respectively. MD and AD showed no significant effects. Sensitivity analyses supported the robustness of these findings. Horizontal pleiotropy and heterogeneity tests indicated minimal evidence of bias, supporting the reliability of our results.</p><h3>Conclusions</h3><p>BMI increases OA risk, with KD and TBMD partially mediating the effect, particularly for KOA. The direct impact of BMI remains predominant, emphasizing the importance of weight reduction, joint protection, and physical activity as preventive measures.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03035-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rate of advance care planning practice during the COVID-19 outbreak in Japan: a cross-sectional survey study","authors":"Hungu Jung,&nbsp;Masahiro Akishita,&nbsp;Yuji Iwamoto,&nbsp;Junpei Tanabe,&nbsp;Kenta Hirohama,&nbsp;Shinya Ishii","doi":"10.1007/s40520-025-03004-9","DOIUrl":"10.1007/s40520-025-03004-9","url":null,"abstract":"<div><h3>Background</h3><p>Advance care planning (ACP) ensures that future care is provided during serious illness, considering an individual’s wishes; it is particularly important for older adults. Regarding ACP practices during the coronavirus disease (COVID-19) outbreak, although there are reports on patients, reports on geriatricians are scarce.</p><h3>Aim</h3><p>This study evaluated the rate of ACP practice during the COVID-19 outbreak through a questionnaire survey of geriatricians.</p><h3>Methods</h3><p>This cross-sectional study surveyed geriatric specialists, who were members of the Japanese Geriatric Society, between October and December 2022 using an anonymous online questionnaire. The questionnaire covered the treatment of COVID-19 patients, difficulties encountered when caring for older patients with COVID-19 infection, and COVID-19 sequelae. Multiple logistic regression with a forward stepwise method was performed to determine the factors associated with ACP practices.</p><h3>Results</h3><p>Of the 258 surveyed doctors, 74 (28.7%) practiced ACP. Multiple logistic regression identified that age 20–49 years and experience in treating (or visiting facilities to treat) patients with COVID-19 infection were factors related to doctors that were significantly and positively associated with ACP practice. Additionally, a significant decline in the patients’ cognitive functions and difficulties in preventing COVID-19 infection were positively associated with ACP practiced by doctors.</p><h3>Conclusions</h3><p>This study suggested that ACP should be practiced for older patients with dementia before COVID-19 infection, which would worsen their dementia symptoms. Moreover, ACP should be emphasized for older patients admitted to facilities. Our results could help devise effective measures to facilitate ACP practices.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03004-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical modalities for the treatment of knee osteoarthritis: a network meta-analysis","authors":"Xiangzhou Lan,&nbsp;Lingjia Li,&nbsp;Qing Jia,&nbsp;Fangyi He,&nbsp;Gaoyan Kuang,&nbsp;Weike Zeng,&nbsp;Miao Chen,&nbsp;Cheng Guo,&nbsp;Zhi Wen,&nbsp;Qing Chen","doi":"10.1007/s40520-025-03015-6","DOIUrl":"10.1007/s40520-025-03015-6","url":null,"abstract":"<div><h3>Objective</h3><p>This network meta-analysis (NMA) aimed to compare the efficacy of various physical modalities in alleviating pain, stiffness, and functional impairment in patients with knee osteoarthritis (KOA).</p><h3>Methods</h3><p>In accordance with PRISMA-P guidelines, we systematically searched nine databases(CNKI, VIP Database, Wanfang Database, SinoMed, PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library) from inception to October 2024 to identify randomized controlled trials (RCTs) evaluating physical therapies for KOA. The interventions assessed included electrical stimulation therapy (EST), low-level light therapy (LLLT), thermotherapy (TT), cryotherapy (CT), and extracorporeal shock wave therapy (ESWT), with resistance and range of motion exercises (RRE) serving as comparators. Outcome measures comprised the Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and 6-minute walk test (6 MWT). Bayesian network meta-analyses and pairwise meta-analyses were performed using Stata 17.0 and R 4.4.1 software.</p><h3>Results</h3><p>32 RCTs involving 2,078 participants were included. LLLT demonstrated the highest efficacy for pain reduction (VAS: MD=–3.32, 95% CI:–3.82 to–0.75; WOMAC pain: MD=–3.74, 95% CI:–6.68 to–0.72) and joint function improvement (SUCRA = 79.8). ESWT ranked second for pain relief (VAS: MD=–1.31, 95% CI:–2.42 to–0.16) and mobility enhancement (6 MWT: SUCRA = 71.5), while TT showed superior efficacy in reducing stiffness (WOMAC stiffness: MD=–2.09, 95%CI:–3.06 to–0.94; SUCRA = 98.1). In contrast, ultrasonic therapy (UT) did not provide significant benefits.</p><h3>Conclusions</h3><p>The findings suggest that LLLT and ESWT may be optimal for pain relief and functional improvement in patients with KOA, whereas TT appears to be the most effective in reducing stiffness. Optimal dosing parameters of these physical modalities are crucial for maximizing clinical benefits. Clinicians should individualize treatment strategies based on patient-specific factors. Future large-scale RCTs are warranted to validate these protocols and address the heterogeneity of existing evidence.</p><h3>Clinical trial number</h3><p>Not applicable.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03015-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep characteristics and physical functioning in middle-aged and elderly adults: findings from Chinese cohorts","authors":"ZhaoLiang Zhang,&nbsp;LieHui Yao","doi":"10.1007/s40520-025-03020-9","DOIUrl":"10.1007/s40520-025-03020-9","url":null,"abstract":"<div><h3>Aims</h3><p>Aging is associated with declines in muscle strength and physical function, and sleep plays a crucial role in maintaining musculoskeletal health. This cohort study, based on the China Health and Retirement Longitudinal Study (CHARLS), aims to explore the relationship between sleep characteristics and physical performance in middle-aged and elderly individuals.</p><h3>Methods</h3><p>A total of 2,998 participants from the CHARLS cohort were included, with baseline data from the 2011 survey and follow-up data from the 2015 survey. Nighttime sleep and napping patterns were assessed, and changes in sleep duration over time were categorized. Physical functioning was assessed through handgrip strength, the chair stand test, the walking test, appendicular skeletal muscle mass, and SPPB scores. Multiple linear regression and restricted cubic spline models were employed to analyze the effects of sleep patterns on muscle health.</p><h3>Results</h3><p>After adjusting for all confounding factors, multifactor liner regression indicated that napping durations exceeding 90 min were associated with reduced grip strength (<i>β</i> = -0.39, 95% CI: -1.43, -0.01, <i>P</i> &lt; 0.05) and longer chair stand test times (<i>β</i> = 0.59, 95% CI: 0.18, 0.99, <i>P</i> &lt; 0.01). The restricted cubic spline indicated a clear U-shaped relationship between nap duration and grip strength (non-linear <i>P</i> &lt; 0.05), whereas no such relationship was observed between nap duration and performance on the chair stand test. In subgroup analyses addressing significant confounding factors, it was found that participants older than 65 years, males, and those with low levels of daily activity exhibited greater sensitivity to the effects of sleep on physical function. The joint analysis showed that compared to individuals with less than 6 h of nighttime sleep and no napping, those with 6–8 h of nighttime sleep and 30–90 min of napping exhibited longer chair stand test durations (<i>β</i> = 0.63, 95% CI: 0.06, 1.20, <i>P</i> &lt; 0.05). Additionally, individuals with 6–8 h of nighttime sleep and naps exceeding 90 min showed longer walking times (<i>β</i> = 1.44, 95% CI: 0.68, 2.21, <i>P</i> &lt; 0.01).</p><h3>Conclusions</h3><p>Both insufficient and excessive nighttime sleep at baseline were linked to diminished physical performance. For older adults, a nap duration approximately 50 min may be potentially optimal for maintaining grip strength. These findings highlight the importance of proper sleep management, particularly for men over 65 years old with low activity levels, in preserving physical function and reducing the risk of mobility decline.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03020-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of residential greenness and ambient particulate matter with hearing impairment in Chinese middle-aged and elderly adults: a nationwide cohort study","authors":"Jia-min Yan,&nbsp;Min-zhe Zhang,&nbsp;Hong-jie Yu,&nbsp;Qi-qiang He","doi":"10.1007/s40520-025-03002-x","DOIUrl":"10.1007/s40520-025-03002-x","url":null,"abstract":"<div><h3>Objective</h3><p>To examine the association of residential greening and atmospheric particulate matter (PM_2.5, PM₁₀) with the risk of hearing impairment in Chinese middle-aged and elderly adults.</p><h3>Methods</h3><p>Data from the China Health and Retirement Longitudinal Study (2011 to 2018 wave) were used. The degree of greening of residential areas were quantified using the Normalized Difference Vegetation Index (NDVI) from the Moderate Resolution Imaging Spectroradiometer (MODIS). PM concentrations were obtained from the CHAP dataset. Hearing impairment was self-reported by the participants. Cox proportional hazards models were used to assess the risk of hearing impairment associated with exposure to residential green spaces and PM. Additionally, the study investigated the potential modifying and mediating role between residential greenery, PM exposure and hearing impairment.</p><h3>Results</h3><p>A total of 13,585 participants aged 61.84 years (Standard deviation: 9.17) were included in this study. Over a span of 7 years, 2,527 cases of hearing impairment were reported, with an incidence rate of 18.6%. A higher degree of residential greenness was inversely associated with the risk of hearing impairment, showing a HR of 0.688 (95%CI: 0.659–0.719) for every 0.1 unit increment in NDVI. In contrast, a 10 µg/m³ elevation in PM_2.5 and PM₁₀ concentration was linked to a 67.6% (HR: 1.676; 95%CI: 1.625–1.729) and 30.4% (HR: 1.304; 95%CI: 1.284–1.324) increased risk of hearing impairment, respectively. The harmful effects of PM_2.5 and PM₁₀ were attenuated with higher levels of residential greenness. Furthermore, the mediation analysis revealed that PM_2.5 and PM₁₀ played a significant mediating role in the association between residential greenery exposure and hearing impairment, with mediation proportions of 47.91% for PM_2.5 and 52.83% for PM₁₀.</p><h3>Conclusions</h3><p>High residential greenness was associated with a reduced risk of hearing impairment, whereas exposure to PM_2.5 and PM₁₀ may increase the risk of hearing impairment. Additionally, residential greenness may modify the relationship between PM exposure and hearing impairment by reducing exposure to PM_2.5 and PM₁₀.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03002-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological effects of music-making interventions for older adults: a systematic review","authors":"Nicole Espinosa,&nbsp;Zoe Menczel Schrire,&nbsp;Andrew C. McKinnon,&nbsp;Hannes Almgren,&nbsp;Loren Mowszowski,&nbsp;Sharon L. Naismith","doi":"10.1007/s40520-025-03006-7","DOIUrl":"10.1007/s40520-025-03006-7","url":null,"abstract":"<div><h3>Background</h3><p>Evidence on the impact of music-making interventions on brain plasticity in older adults is limited.</p><h3>Aims</h3><p>To investigate whether music-making interventions in older adults induce neurobiological changes and if such changes relate to cognitive improvements.</p><h3>Methods</h3><p>A systematic search was conducted in Medline, PsycINFO, and Scopus. Inclusion criteria targeted randomised controlled trials with older adults (with and without mild cognitive impairment [MCI]), music-making interventions as exposure, and neurobiological measures as the primary outcome.</p><h3>Results</h3><p>Six studies (555 cognitively intact older adults) met inclusion criteria—five used piano training, one used choral singing. Three studies had overlapping cohorts, and four had a high risk of bias. One study employed electroencephalography (EEG) to measure frontal and parietal activity, while five used structural MRI to assess cortical, subcortical, and white matter integrity. Methodological heterogeneity limited comparability. Findings in the piano group included increased frontal theta power during an improvisation task, greater grey matter volume in the dorsolateral prefrontal cortex and cerebellum, slower fibre density decline in the fornix and preserved grey matter volume in the right auditory cortex and hippocampus. Only one study reported a positive correlation between neurobiological changes and executive functioning improvements. No studies assessed neurobiological outcomes in MCI.</p><h3>Discussion</h3><p>Evidence on music-making interventions and neuroplasticity in older adults remains inconclusive due to limited studies, high risk of bias, and methodological variability. While preliminary findings suggest potential neurobiological changes with music-making interventions, there is insufficient evidence to draw firm conclusions.</p><h3>Conclusions</h3><p>High-quality trials are needed to clarify the neurobiological impact of music-making, particularly in MCI populations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03006-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength as a predictor of one-year mortality in elderly patients with fragility hip fracture","authors":"Francesco Salis,&nbsp;Irene Buffoli,&nbsp;Maristella Belfiori,&nbsp;Alice Bellisai,&nbsp;Benedetta Gianoglio,&nbsp;Giuseppe Marongiu,&nbsp;Monia Marzuolo,&nbsp;Giuseppe Navarra,&nbsp;Veronica Piras,&nbsp;Benedetta Puxeddu,&nbsp;Luisa Sanna,&nbsp;Chiara Scudu,&nbsp;Antonio Capone,&nbsp;Antonella Mandas","doi":"10.1007/s40520-025-03019-2","DOIUrl":"10.1007/s40520-025-03019-2","url":null,"abstract":"<div><h3>Background</h3><p>Fragility fractures occur on porotic bones due to minor trauma and are associated with high rates of disability and mortality.</p><h3>Aims</h3><p>To evaluate the ability of handgrip strength to predict one-year mortality in elderly patients with fragility hip fracture.</p><h3>Methods</h3><p>We enrolled patients aged 65 years and older with fragility hip fractures admitted to an Italian orthopedic unit. They underwent a comprehensive geriatric assessment, including handgrip strength measurement, and all received surgical intervention.</p><h3>Results</h3><p>Among the 322 enrolled patients (median age: 84 years; 75.2% women), the one-year mortality rate was 15.5%. According to the European Working Group on Sarcopenia in Older People 2 guidelines, 235 subjects (73.0%) exhibited low handgrip strength. This group revealed HR: 2.36 (95%CI: 1.06–5.24) for one-year mortality compared to the group with adequate handgrip strength (<i>p</i> = 0.036). After adjusting for age and risk of adverse event, through Multidimensional Prognostic Index, the HR decreased to 1.31 (95%CI: 0.56–3.07), with a lower validity.</p><h3>Discussion</h3><p>Our study found a slightly lower one-year mortality than other studies with similar samples, probably due to the co-management of orthopedic and geriatric teams. As for the main outcome, low handgrip strength was significantly associated with one-year mortality. However, the significance diminished when considering possible confounding variables, despite a lower precision of the model.</p><h3>Conclusions</h3><p>Low handgrip strength predicts one-year mortality in elderly people with fragility hip fractures. Further studies are needed to explore the possible influence of confounders.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03019-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with mild cognitive impairment and dementia amongst the oldest old: findings based on the nationally representative “old age in Germany (D80+)” study","authors":"André Hajek,&nbsp;Razak M. Gyasi,&nbsp;Liang-Kung Chen,&nbsp;Karl Peltzer,&nbsp;Hans-Helmut König","doi":"10.1007/s40520-025-03022-7","DOIUrl":"10.1007/s40520-025-03022-7","url":null,"abstract":"<div><h3>Background/Aims</h3><p>Particularly among the oldest old, there is restricted knowledge regarding the factors associated with mild cognitive impairment and dementia using data from large, nationally representative samples. Thus, our aim was to address this knowledge gap.</p><h3>Methods/Design</h3><p>We used data from the nationally representative “Old Age in Germany (D80+)” study covering community-dwelling and institutionalized individuals in the entire country (<i>n</i> = 2,555). Mean age was 85.5 years (SD: 4.2), ranging from 80 to 100 years (61.7% of the participants were female). The DemTect was used to measure cognitive impairment in terms of probable mild cognitive impairment and probable dementia. Sociodemographic, lifestyle-related, psychosocial and health-related independent variables were included in the multinomial regression analysis.</p><h3>Results</h3><p>In the analytic sample, 57.8% of the individuals did not have cognitive impairment, 24.2% of the individuals had mild cognitive impairment and 18.0% had probable dementia. Regression analysis identified some sociodemographic (e.g., advanced age, being male, lower education), lifestyle-related (lower cognitive activities), psychosocial (higher loneliness and absence of meaning in life), as well as health-related (e.g., functional impairment) factors associated with probable MCI and probable dementia. Loneliness was only associated with these outcomes among women, but not men.</p><h3>Discussions</h3><p>Based on large, nationally representative data, this study revealed several factors associated with probable MCI and dementia – which enhances our current understanding mainly based on small or selective samples.</p><h3>Conclusion</h3><p>Such knowledge may help to address those at risk for cognitive impairment. Longitudinal studies are required to gain further insights.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03022-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship among socioeconomic status, social support and frailty: is there a gender difference?","authors":"Ping Dong,&nbsp;Xian-qi Zhang,&nbsp;Wen-qiang Yin,&nbsp;Zi-yuan Li,&nbsp;Xiao-na Li,&nbsp;Min Gao,&nbsp;Yong-li Shi,&nbsp;Hong-wei Guo,&nbsp;Zhong-ming Chen","doi":"10.1007/s40520-025-03013-8","DOIUrl":"10.1007/s40520-025-03013-8","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to determine the relationship among socioeconomic status, social support and frailty, and its gender difference.</p><h3>Methods</h3><p>Education and income were combined to indicate the socioeconomic status. The Social Support Rating Scale (SSRS) was used to measure the level of social support. Frailty was measured by the FRAIL Scale. Mediation effects were analyzed using the PROCESS 4.1 macro in SPSS version 26.0.</p><h3>Results</h3><p>Among the 936 participants, socioeconomic status had a direct effect on frailty (effect = − 0.088, 95% <i>CI</i>: − 0.142, − 0.021). Social support was an indirect pathway for the relationship between socioeconomic status and frailty (effect = − 0.011, 95% <i>CI</i>: − 0.023, − 0.003), accounting for 11.11% of the total effect. Stratified by gender, we found that the total, direct and indirect effects of socioeconomic status on frailty were significant only in the female subsample.</p><h3>Conclusion</h3><p>Overall, there was a significant association between socioeconomic status and frailty among the rural older adults, and social support mediated this relationship. However, there were gender differences in the association among socioeconomic status, social support and frailty. Specifically, the correlation between socioeconomic status and frailty and the mediating role of social support were found only in the female subsample. The public health sector should focus on the rural older adults with low socioeconomic status and lack of social support, taking targeted interventions to avoid and delay the occurrence and progress of frailty.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03013-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}