Aging Clinical and Experimental Research最新文献

{"title":"Association between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults.","authors":"Lee Smith, Guillermo F López Sánchez, Pinar Soysal, Nicola Veronese, Masoud Rahmati, Karel Kostev, Louis Jacob, Mark A Tully, Fiona Richardson, Laurie Butler, Yvonne Barnett, Helen Keyes, Jae Il Shin, Ai Koyanagi","doi":"10.1007/s40520-025-03135-z","DOIUrl":"10.1007/s40520-025-03135-z","url":null,"abstract":"<p><strong>Objectives: </strong>Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa).</p><p><strong>Methods: </strong>We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer's Association criteria were used to define MCI. Multivariable logistic regression was performed.</p><p><strong>Results: </strong>Data on 32,715 individuals aged ≥ 50 years were analyzed [mean (SD) age 62.1 (15.6) years; 48.3% males]. Among those aged 50-64 years, dynapenia alone and DAO were significantly associated with MCI with the OR for DAO (OR = 1.79; 95%CI = 1.26-2.56) being higher than that of dynapenia alone (OR = 1.40; 95%CI = 1.15-1.71). In those aged ≥ 65 years, only dynapenia alone (OR = 1.53; 95%CI = 1.23-1.89) was significantly associated with MCI but not DAO. Abdominal obesity alone was not significantly associated with MCI in both age groups.</p><p><strong>Conclusions: </strong>Among community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"235"},"PeriodicalIF":3.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of abuse among older adults registered with health centers in Southern Tehran: a population-based study.","authors":"Mohammadreza Askari, Fatemeh Bahramnezhad, Farshad Sharifi, Elham Navab","doi":"10.1007/s40520-025-03137-x","DOIUrl":"10.1007/s40520-025-03137-x","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"234"},"PeriodicalIF":3.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight of time: exploring the link between obesity and aging.","authors":"Francesco Saverio Ragusa, Toshiko Tanaka, Nicola Veronese, Pasquale Mansueto, Ligia J Dominguez, Mario Barbagallo, Luigi Ferrucci","doi":"10.1007/s40520-025-03106-4","DOIUrl":"10.1007/s40520-025-03106-4","url":null,"abstract":"<p><p>Obesity and aging are interrelated public health concerns, with growing prevalence, especially as global demographics shift toward an older population. This narrative review explores the mechanisms through which obesity accelerates the aging process, focusing on major aging pathways affected by obesity, including deregulated nutrient sensing, telomeres attrition, epigenetic alterations, mitochondrial dysfunction, stem cell exhaustion, and altered intercellular communication. Evidence suggests that these disruptions not only drive age-related diseases, such as cardiovascular disease, type 2 diabetes, and neurodegenerative conditions, but also exacerbate mobility limitations, cognitive decline, and reduced quality of life in older adults. The role of lifestyle interventions, particularly adherence to the Mediterranean diet, is emphasized for its anti-inflammatory and metabolic benefits, alongside strategies to address the social and psychological impacts of obesity on aging. By recognizing obesity as a significant modifiable risk factor for accelerated aging, this review advocates comprehensive and targeted interventions to promote healthier aging and improve quality of life in older populations globally.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"236"},"PeriodicalIF":3.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with hospitalization from a geriatric short-stay unit (OBI-GER): a retrospective cohort study.","authors":"Laura Orlandini, Benedetta Maisano, Alice Margherita Ornago, Elena Pinardi, Alberto Finazzi, Andrea Bonini, Maurizio Corsi, Giacomo Mosca, Ernesto Contro, Andrea Staglianò, Martina Manna, Antonio Piscitelli, Aida Andreassi, Maria Cristina Ferrara, Chukwuma Okoye, Giuseppe Bellelli","doi":"10.1007/s40520-025-03125-1","DOIUrl":"10.1007/s40520-025-03125-1","url":null,"abstract":"<p><strong>Background: </strong>Geriatric Short-Stay Observation Units (G-SSU) are specialized units designed to improve care for older adults within the emergency department (ED). At our hospital, the Osservazione Breve Intensiva Geriatrica (OBI-GER) was established as a dedicated G-SSU.</p><p><strong>Aims: </strong>This study aims to characterize the clinical profile of older adults admitted to OBI-GER and identify factors associated with hospitalization within the first 24 h of admission.</p><p><strong>Methods: </strong>Retrospective, single-center study including individuals aged ≥ 75 years, admitted to OBI-GER between August 2023 and August 2024, with frailty and/or delirium during ED stay. Multivariable logistic regression model with stepwise selection was used to assess associations between hospitalization and clinical, functional, laboratory, and organizational variables.</p><p><strong>Results: </strong>Overall, 353 patients (mean age 86.8 ± 5.5 years, 47.9% male) were included, of whom 109 (30.8%) required hospitalization. The cohort exhibited moderate frailty (median Clinical Frailty Scale = 6, IQR 6-7) and a considerable comorbidity burden (median Charlson Comorbidity Index [CCI] = 6, IQR 5-8), along with a high prevalence of dementia (45%) and polypharmacy (mean 7.1 ± 3.4 medications). Independent risk factors for hospitalization included higher CCI (OR 1.19, 95% CI 1.05-1.35), delirium on the first day of OBI-GER (OR 2.03, 95% CI 1.13-3.64), frequent faller profile (OR 2.66; 95% CI 1.38-5.12), and lower hemoglobin levels at ED admission (OR 0.89, 95% CI 0.79-0.99).</p><p><strong>Conclusions: </strong>Despite their clinical complexity, only one-third of patients admitted to OBI-GER required hospitalization. CCI, delirium, fall history, and hemoglobin levels may serve to stratify hospitalization risk and optimize patient selection for G-SSU.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"231"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal link between osteoarthritis and falls: the mediating role of paracetamol.","authors":"Jian Huang, Xiaodong Hu, Tianrui Wang, Yingze Zhang, Lu Wang","doi":"10.1007/s40520-025-03138-w","DOIUrl":"10.1007/s40520-025-03138-w","url":null,"abstract":"<p><strong>Background: </strong>Some observational studies have indicated that osteoarthritis (OA) is a fall risk factor. However, the causal relationship between OA and falls remains unclear.</p><p><strong>Methods: </strong>We conducted a two-step Mendelian randomization (MR) to investigate the causal relationships between OA, paracetamol use, and the risk of falls and to estimate the mediating effect of paracetamol use. Publicly accessible data for hip OA, knee OA, paracetamol use, and falling risk were sourced from Genome-Wide Association Studies (GWAS).</p><p><strong>Result: </strong>In the forward MR analysis, the Inverse Variance Weighted (IVW) method indicated that a genetic predisposition to hip OA was significantly associated with an increased risk of falls (OR: 1.053, 95% CI: 1.014 to 1.094, P = 0.007). Consistent directions of effect were observed across other MR analysis methods. The mediated proportion of paracetamol use on the relationship between hip OA and falling risk was 21.70% (β = 0.0113, 95% CI: 5.73-37.8%, P = 0.0078). No causal relationship was observed between knee OA and falling risk, nor between knee OA and the use of paracetamol. In the reversed MR analysis, the IVW method showed that a genetic predisposition to falls may not increase the risk of developing hip and knee OA.</p><p><strong>Conclusion: </strong>These results provide genetic evidence for a causal effect of hip OA on fall risk, partially mediated by paracetamol, and underscore the importance of fall prevention education and cautious paracetamol use for patients with hip OA.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"232"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical prediction models using artificial intelligence approaches in dementia.","authors":"Nicola Veronese, Francesco Bolzetta, Livia Gallo, Giorgia Durante, Laura Vernuccio, Carlo Saccaro, Caterina Maria Gambino, Carlo Custodero, Piero Portincasa, Andrea Morotti, Alice Galli, Chiara Trasciatti, Alessandro Padovani, Andrea Pilotto, Mario Barbagallo","doi":"10.1007/s40520-025-03112-6","DOIUrl":"10.1007/s40520-025-03112-6","url":null,"abstract":"<p><strong>Background: </strong>While nearly half of all dementia cases are potentially preventable, early detection and targeted interventions are critical. Artificial intelligence (AI)-enhanced clinical prediction models offer promising tools to improve diagnostic and prognostic accuracy by leveraging machine learning (ML) to integrate diverse data sources. This systematic review evaluates the development, performance, and clinical applicability of AI-based prediction models in dementia.</p><p><strong>Methods: </strong>Searches of PubMed, Embase, and Web of Science identified peer-reviewed studies up to October 2024, focusing on AI-based models predicting dementia onset. Included studies were assessed for model accuracy, bias, and generalizability using the PROBAST tool. Data extraction adhered to the TRIPOD and CHARMS frameworks, capturing study design, participant demographics, predictor variables, and performance metrics.</p><p><strong>Results: </strong>Among 2699 articles initially screened, 21 studies were included, encompassing over 1 million participants. AI models, extremely heterogenous for their nature, demonstrated good predictive accuracy, with a mean area under the curve of 0.845. While internal validation was conducted in all studies, external validation was limited. Models incorporating ML methods like random forests and support vector machines outperformed traditional approaches. The most used parameters were clinical and cognitive data, whilst data about biomarkers were the less used. Risk of bias was generally low, though calibration and generalizability remained challenges.</p><p><strong>Conclusions: </strong>AI-based prediction models show strong potential for early dementia detection and personalized care. However, their integration into clinical practice requires addressing issues of external validation, data representativeness, and model interpretability. Further research should focus on robust validation and ethical implementation to optimize their utility in dementia care.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"233"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram-based prediction model for motoric cognitive risk syndrome in patients with coronary artery disease: a cross-sectional study.","authors":"Yiyi Chai, Qingfang Ye, Xiaomin Wu, Yanrong Gu, Zheng Zhang, Dou Zhu, Yini Wang, Ping Lin, Ling Li","doi":"10.1007/s40520-025-03132-2","DOIUrl":"10.1007/s40520-025-03132-2","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) is well known to be associated with dementia, motoric cognitive risk syndrome (MCR) has been identified as a predictor of dementia, with MCR and CAD potentially sharing common pathophysiological mechanisms. Identifying MCR in CAD patients is beneficial for the prevention of dementia. This study aims to investigate the incidence and identify the risk factors of MCR in CAD patients, and further establish a visual risk prediction model.</p><p><strong>Methods: </strong>A cross-sectional study. From September 2023 to December 2023, we enrolled 413 CAD patients for this study. Patients were randomly grouped into a training cohort (80%) and a validation cohort (20%). The least absolute shrinkage and selection operator regression model and multivariate logistic regression analysis were used to select variables and develop a prediction model in the training cohort. In both the training and validation cohorts: ROC curve was used to evaluate the differentiation of the nomogram model; the calibration curve was used to evaluate the consistency of the model; the decision curve analysis was used to evaluate the efficiency of the nomogram.</p><p><strong>Results: </strong>In this study, the prevalence of MCR was 13.8%. Four risk predictors, namely polypharmacy, handgrip strength, Gensini score, and neutrophil counts, were screened and used to develop a nomogram model. The ROC curve of the training set was 0.781 (95%CI: 0.71, 0.86). Similar ROC curve was achieved at validation set 0.780 (95%CI: 0.62, 0.94). The Hosmer-Lemeshow test in the training, and testing cohorts were p = 0.993, and p = 0.782, calibration curve analysis demonstrated that the model was well-calibrated. DCA exhibited this model with clinical utility.</p><p><strong>Conclusion: </strong>We developed a nomogram that could help clinicians identify high-risk groups of MCR in middle-aged and elderly CAD patients for early intervention.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"229"},"PeriodicalIF":3.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone status in patients with chronic hypoparathyroidism: results from the Italian HypoparaNET database.","authors":"Francesca Marini, Francesca Giusti, Blandine Weiss, Michel Ovize, Salvatore Benvenga, Filomena Cetani, Annamaria Colao, Sabrina Corbetta, Marta Bondanelli, Maurizio Iacobone, Andrea Lenzi, Giovanna Mantovani, Rosaria Maddalena Ruggeri, Luigi di Filippo, Andrea Giustina, Dalal S Ali, Aliya A Khan, Gemma Marcucci, Maria Luisa Brandi","doi":"10.1007/s40520-025-03139-9","DOIUrl":"10.1007/s40520-025-03139-9","url":null,"abstract":"<p><strong>Background: </strong>Chronic hypoparathyroidism (HypoPT) is a rare endocrine condition, having variable etiology, characterized by low parathyroid hormone levels, leading to reduced calcium levels and increased phosphorus values in the blood. Bone health is an important clinical aspect to be considered in patients with HypoPT, whose skeleton is exposed both to the HypoPT-induced alteration of bone mass and microarchitecture, and to the natural occurrence and progression of bone mass loss due to menopause and ageing.</p><p><strong>Aim: </strong>Investigating bone status in a cohort of Italian HypoPT patients from the HypoparaNET database.</p><p><strong>Methods: </strong>In this cross-sectional study, we retrospectively analyzed bone status in 162 adult, and 11 children and adolescent HypoPT cases, based to their sex, age, HypoPT etiology, urinary excretion of calcium and phosphate, and serum level of 25(OH)-vitamin D.</p><p><strong>Results: </strong>Overall prevalence of osteoporosis in adult HypoPT patients was found to be slightly lower to that of the general population (17.3% vs 18.3%), increasing with ageing and being more frequent in postmenopausal women. Data from our HypoPT cohort confirmed that ageing and female sex are independent risk factors for osteoporosis, even among individuals with HypoPT.</p><p><strong>Discussion: </strong>Results from this study suggest the importance of a regular follow-up of bone health in HypoPT, especially in postmenopausal women and young patients with a genetic form of HypoPT.</p><p><strong>Conclusions: </strong>Medical therapies aim at restoring a balanced bone turnover and preventing bone tissue loss could be indicated in HypoPT cases with reduced bone mass to grant a better bone health at any age.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"230"},"PeriodicalIF":3.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization.","authors":"Chenke Jiang, Yihong Gan, Shengyu Chen, Jie Yao, Yilin Zhang, Yongsheng Fan, Xinchang Wang, Li Xu","doi":"10.1007/s40520-025-03043-2","DOIUrl":"10.1007/s40520-025-03043-2","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have shown that physical activity and sedentary behavior are associated with aging. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess the genetic correlation and causal relationships between genetically predicted physical activity, sedentary behavior, and aging.</p><p><strong>Methods: </strong>Using linkage disequilibrium score regression (LDSC) and Mendelian Randomization (MR). Genetic variants associated with leisure screen time (LST, as an indicator of sedentary behavior), moderate-to-vigorous physical activity (MVPA), and four aging-related traits (90th survival percentile, facial aging, telomere length, and frailty index) were obtained from genome-wide association studies (GWAS). The primary MR analyses were performed using the inverse variance weighted (IVW) method, followed by various sensitivity and validation analyses.</p><p><strong>Results: </strong>Univariable MR analysis indicated significant associations of LST with telomere length (β = - 0.04, P = 4.95E-06), and facial aging (β = 0.11, P = 2.28E-09), frailty index (β = 0.17, P = 1.93E-35). MVPA had a significant causality with the frailty index (β = - 0.28, P = 6.46E-09). These associations weakened in Multivariable MR Analysis, but the frailty index remained significantly correlated after adjustment. LDSC further supported the genetic correlations identified in the MR analysis. Additionally, pathway analyses, including the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO), highlighted potential mechanisms linking LST and aging outcomes.</p><p><strong>Conclusions: </strong>This study reveals that LST and MVPA may play a causal role in the process of aging. Accordingly, public health efforts to promote increased physical activity and reduce sedentary time can effectively combat accelerated aging.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"227"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of colorectal cancer attributable to diet low in milk among middle-aged and elderly population from 1990 to 2021: a population-based study.","authors":"Juan Liu, Haolin Sun, Xixi Zheng, Nina Ma, Xiaoling Liu, Ruizhen Cao, Mudan Yang, Bangwei Cao","doi":"10.1007/s40520-025-03129-x","DOIUrl":"10.1007/s40520-025-03129-x","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the global burden of colorectal cancer (CRC) attributable to diet low in milk among middle-aged and elderly populations from 1990 to 2021 and projects future trends to 2050.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease (GBD) 2021 study were obtained via the Global Health Data Exchange. The burden was assessed using number of cases and rates of Disability-Adjusted Life Years (DALY) and death, stratified by age, sex, region, nation, and Socio-Demographic Index (SDI). Temporal trends were analyzed using estimated annual percentage change (EAPC), and future trends were projected using the Bayesian Age-Period-Cohort (BAPC) model.</p><p><strong>Results: </strong>In 2021, the global DALY and death cases of CRC attributable to a diet low in milk among middle-aged and elderly populations was 2.71 million and 0.14 million, respectively, representing increases of 92.81% and 103.02% from 1990. However, the corresponding DALY and death rates decreased from 209.65 to 182.64 per 100,000 population and from 9.96 to 9.13 per 100,000 population, respectively, with EAPCs of - 0.54 and - 0.36. The DALY and death rates rise with age, peaking in the 95 + age group. From 1990 to 2021, among regions, Southern Sub-Saharan Africa and Eastern Europe saw the largest increases in these rates, while Australasia, High-income North America, and Western Europe had the largest decreases. At the national level, Lesotho, Cabo Verde, and Georgia saw the largest increases in the DALY and death rates, while Austria, Australia, and Germany experienced the largest decreases. The correlation analysis showed that the DALY and death rates across 21 regions increased with rising SDI levels up to approximately 0.67, then declined and stabilized. Projections suggest a significant rise in DALY and death cases, with a slight increase in DALY and death rates.</p><p><strong>Conclusions: </strong>The burden of CRC attributable to a diet low in milk remains substantial among middle-aged and elderly populations globally, with significant age, sex, regional and national disparities. These findings highlight the need for targeted dietary interventions to mitigate the growing burden of CRC among middle-aged and elderly populations.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":"228"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}