Aging Clinical and Experimental Research最新文献

{"title":"Food as medicine: white and whole-grain bread consumption in relation to sarcopenia among older adults, insights from the Birjand Longitudinal Aging Study (BLAS)","authors":"Zohreh Sajadi Hezaveh,&nbsp;Farshad Sharifi,&nbsp;Hossein Fakhrzadeh,&nbsp;Huriye Khodabakhshi,&nbsp;Masoumeh Khorashadizadeh,&nbsp;Moloud Payab,&nbsp;Mahbube Ebrahimpur,&nbsp;Hanieh-Sadat Ejtahed,&nbsp;Mitra Moodi","doi":"10.1007/s40520-025-03162-w","DOIUrl":"10.1007/s40520-025-03162-w","url":null,"abstract":"<div><p>This study aimed to examine the association between energy-adjusted consumption patterns of different types of bread, including whole-grain and white bread, and the risk of sarcopenia in older adults. In this cross-sectional study, sarcopenia was assessed using three tests: appendicular skeletal muscle mass (ASMM), handgrip strength, and gait speed, in 1,325 older adults from the Birjand Longitudinal Aging Study (BLAS), conducted between September 2018 and April 2019. Bread consumption was evaluated through a semi-quantitative food frequency questionnaire. Consumption patterns of whole-grain and white bread were identified via factor analysis, adjusted for energy intake, and categorized into quartiles. In total, 28% of participants had sarcopenia. The highest quartile of the white bread pattern was associated with a 56% increased risk of low ASMM (OR: 1.56; 95% CI: 1.03 to 2.37, <i>P</i> = 0.04) and a twofold increase in the risk of low handgrip strength (OR: 2.00; 95% CI: 1.47 to 2.74, <i>P</i> &lt; 0.001). In contrast, higher adherence to the whole-grain bread pattern significantly reduced the risk of low handgrip strength (OR: 0.68; 95% CI: 0.48 to 0.95, <i>P</i> = 0.02). No significant association was found between either bread pattern and gait speed. Higher whole-grain bread intake was inversely associated with sarcopenia (OR: 0.63; 95% CI: 0.44 to 0.90, <i>P</i> = 0.01), while white bread intake increased the odds (OR: 1.64; 95% CI: 1.14 to 2.37, <i>P</i> = 0.01). Overall, greater whole-grain bread consumption was linked to better muscle strength, whereas white bread intake was associated with weaker muscles, muscle loss, and sarcopenia in older adults. Given the cross-sectional nature of this study, further research is needed to explore the underlying mechanisms and clarify the direction of these associations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03162-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remimazolam versus propofol for postoperative delirium prevention in geriatric surgery: A systematic review and meta-analysis of randomized controlled trials","authors":"Rui-jun Tong,&nbsp;Yue-zhong Lv,&nbsp;Ya-fen Shi,&nbsp;Lan Lai,&nbsp;Qi-hong Shen","doi":"10.1007/s40520-025-03166-6","DOIUrl":"10.1007/s40520-025-03166-6","url":null,"abstract":"<div><h3>Background</h3><p>As a novel ultra-short-acting benzodiazepine derivative, remimazolam’s impact on postoperative neurocognitive recovery remains poorly characterized. Our research specifically evaluated its influence on postoperative delirium (POD) incidence compared with propofol in the geriatric surgical population.</p><h3>Methods</h3><p>A comprehensive literature search was performed across four electronic databases, including the Cochrane Library, PubMed, Embase, and Web of Science, to identify eligible randomized controlled trials (RCTs). The methodological quality of the included studies was assessed using the Cochrane Collaboration’s risk of bias tool. Statistical analyses were performed using Review Manager 5.3 software; effect estimates were expressed as risk ratios (RR), standardized mean differences (SMD), and 95% confidence intervals (CI). The overall quality of the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.</p><h3>Results</h3><p>The meta-analysis incorporated five RCTs encompassing 1,368 patients. Pooled analysis revealed no statistically significant difference in POD incidence between the remimazolam and propofol groups (RR = 0.88, 95% CI: 0.58–1.33; <i>P</i> = 0.53). However, remimazolam administration was associated with a significant reduction in hypotensive events (RR = 0.55, 95% CI: 0.34–0.90; <i>P</i> &lt; 0.05). No between-group differences were detected in postoperative nausea and vomiting incidence.</p><h3>Conclusion</h3><p>The current meta-analysis provided evidence that perioperative remimazolam administration did not significantly increase the risk of POD in elderly surgical patients, while demonstrating clinically significant benefits in hemodynamic stability.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03166-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directional postural sway tendencies and static balance among community-dwelling older adults with depression and without cognitive impairment","authors":"Jethro Raphael M. Suarez,&nbsp;Veronica B. Decker,&nbsp;Joon-Hyuk Park,&nbsp;Nichole R. Lighthall,&nbsp;Michael Joseph S. Dino,&nbsp;Ladda Thiamwong","doi":"10.1007/s40520-025-03144-y","DOIUrl":"10.1007/s40520-025-03144-y","url":null,"abstract":"<div><h3>Background</h3><p>Depression is prevalent among older adults and is known to negatively affect balance, ultimately leading to falls. However, few studies have investigated the effect of depression on static balance metrics beyond postural sway distance and area of older adults without mild cognitive impairment (MCI).</p><h3>Aims</h3><p>To investigate if postural sway distance, sway area, medial-lateral (ML) sway range, anterior-posterior (AP) sway range, and center-of-pressure (COP) sway speed variability differed between non-cognitively impaired older adults with minimal-to-no depression (Minimally Depressive group) and mild-to-severe depression (Mildly-to-Severely Depressive group).</p><h3>Methods</h3><p>A total of 204 community-dwelling older adults were included. Depression was measured using the Patient Health Questionnaire-9 (PHQ-9), MCI using the Rowland Universal Dementia Assessment Scale (RUDAS), and static balance metrics using the Balance Tracking System (BTrackS). Mann-Whitney U tests determined differences between groups.</p><h3>Results</h3><p>Sway area, AP sway range, and ML sway range were significantly greater in the Mildly-to-Severely Depressive group than the Minimally Depressive group (<i>p</i> = 0.010, <i>p</i> = 0.016, and <i>p</i> = 0.031, respectively). Sway distance (<i>p</i> = 0.445) and COP sway speed variability (<i>p</i> = 0.193) were not significantly different between groups.</p><h3>Discussion</h3><p>The findings revealed greater sway area, as well as greater ranges in the AP and ML directions, in the Mildly-to-Severely Depressive group when compared to the Minimally Depressive Group. Reduced concentration and affected postural stabilization mechanisms driven by depression may have attributed to these results.</p><h3>Conclusions</h3><p>This study highlights the need for further understanding of how static balance metrics, such as directional sway, are affected by depression, thereby creating interventions tailored to individual’s postural sway characteristics to help reduce fall risk and improve balance.</p><h3>Trial registration</h3><p>ClinicalTrials.gov (NCT05778604).</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03144-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between intrinsic capacity and sarcopenia in older adults with type 2 diabetes: A cross-sectional study","authors":"Chia-Ling Lin,&nbsp;Hsueh-Ching Wu,&nbsp;Neng-Chun Yu,&nbsp;Yuan-Ching Liu,&nbsp;Chia-Ling Wu,&nbsp;Wu-Chien Chien","doi":"10.1007/s40520-025-03160-y","DOIUrl":"10.1007/s40520-025-03160-y","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the association between intrinsic capacity (IC) and sarcopenia among older adults with type 2 diabetes mellitus (T2D).</p><h3>Methods</h3><p>This cross-sectional study included 409 community-dwelling older adults with T2D (mean age: 71.2 ± 5.8 years; 207 men, 202 women). IC was assessed using the WHO framework across five domains: cognition (Brain Health Test), locomotion (Short Physical Performance Battery), vitality (Mini Nutritional Assessment–Short Form), sensory (vision and hearing tests), and psychological function (15-item Geriatric Depression Scale). Each impaired domain contributed one point to the total IC impairment score (range: 0–5), with higher scores indicating greater IC decline. Sarcopenia was defined based on the 2019 Asian Working Group for Sarcopenia (AWGS) criteria, including muscle mass, grip strength, and physical performance. Multiple logistic regression was used to examine associations between IC impairment and sarcopenia.</p><h3>Results</h3><p>The prevalence of sarcopenia was 13.4%, and the average IC impairment score was 0.8 ± 0.8. The most common impairments were hearing (42.1%) and vision (13.2%). Participants with sarcopenia had a significantly higher number of IC impairments. A greater number of impaired IC domains was associated with increased odds of sarcopenia. While locomotion and visual impairments showed a positive association, they were not statistically significant after adjusting for confounders.</p><h3>Conclusions</h3><p>Declines in IC, particularly in locomotion and sensory domains, were associated with higher likelihood of sarcopenia in older adults with T2D. Routine IC assessment may support early detection and preventive interventions in this high-risk population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03160-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity patterns and mortality in older adults: a two-cohort pooled analysis","authors":"Cecilia Damiano,&nbsp;Simona Costanzo,&nbsp;Benedetta Marcozzi,&nbsp;Teresa Panzera,&nbsp;Chiara Donfrancesco,&nbsp;Augusto Di Castelnuovo,&nbsp;Cinzia Lo Noce,&nbsp;Sara Magnacca,&nbsp;Federico Triolo,&nbsp;Maria Beatrice Zazzara,&nbsp;Luigi Palmieri,&nbsp;Licia Iacoviello,&nbsp;Graziano Onder,&nbsp;Davide Liborio Vetrano,&nbsp;for the BIO-SIGN Study Investigators","doi":"10.1007/s40520-025-03150-0","DOIUrl":"10.1007/s40520-025-03150-0","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background\u0000 <p>Different multimorbidity patterns can affect health trajectories and influence survival.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Aims\u0000 <p>We investigated their association with mortality in two population-based cohorts of older adults.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>Two Italian cohorts of randomly selected individuals (60–79 years old) from general population: CUORE (baseline 2008–2012) and Moli-sani (baseline 2005–2010). Latent Class Analysis used to identify homogeneous groups of multimorbid individuals (≥ 2 diseases) with similar underlying disease patterns. Cox regression models used to assess the association of multimorbidity patterns and all-cause mortality (end of follow-up 12/31/2019). Results pooled in a random-effects meta-analysis.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results\u0000 <p>Total samples of 3,695 individuals in CUORE (48% male, mean age 68.8 years [SD 5.6]) and 7,801 in Moli-sani (51% male, mean age 68.2 years [SD 5.4]). In both cohorts, six multimorbidity patterns were identified and named after their overexpressed diseases: <i>hypercholesterolemia; metabolic</i>,<i> depression and cancer; cardiometabolic and respiratory; gastrointestinal</i>,<i> genitourinary and depression; respiratory; unspecific</i> (i.e., no diseases overexpressed). Overall mortality rates were 1.66 per 100 person/years in CUORE and 1.85 per 100 person/years in Moli-sani. Compared to the multimorbidity-free group (&lt; 2 diseases), individuals displaying a <i>cardiometabolic and respiratory</i> pattern showed the highest mortality (pooled HR 2.62, 95% CI 2.15–3.10), followed by <i>unspecific</i> (pooled HR 1.45, 95% CI 1.21–1.68), <i>respiratory</i> (pooled HR 1.33, 95% CI 1.01–1.64) and <i>gastrointestinal</i>,<i> genitourinary and depression</i> (pooled HR 1.33, 95% CI 1.06–1.60).</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Discussion\u0000 <p>Multimorbidity patterns in older adults are differentially associated to shorter survival.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusions\u0000 <p>Their identification may help optimize clinical management by improving risk stratification, allowing for more targeted prevention and intervention strategies.</p>\u0000 \u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03150-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex‑specific effects of aging and glycemic control on the association of possible sarcopenia in older adults with type 2 diabetes: a cross-sectional study","authors":"Yi-Fang Huang,&nbsp;Shih-Ping Liu,&nbsp;Chih-Hsin Muo,&nbsp;Chen-Yi Lai,&nbsp;Chung-Ta Chang","doi":"10.1007/s40520-025-03159-5","DOIUrl":"10.1007/s40520-025-03159-5","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to investigate sex-specific associations and the synergistic effects of aging and glycemic control on the correlation of possible sarcopenia in older adults with type 2 diabetes mellitus (T2DM).</p><h3>Methods</h3><p>In the cross-sectional study of community-dwelling adults aged ≥ 60 years in New Taipei City, Taiwan, Sarcopenia status was classified using the Asian Working Group for Sarcopenia 2019 criteria into possible sarcopenia, sarcopenia, and severe sarcopenia. Categorical and continuous variables were compared using chi-square/Fisher’s exact tests and ANOVA. Sex-specific associations between glycemic control and sarcopenia were examined using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).</p><h3>Results</h3><p>5,728 participants (mean age 72.1 ± 6.1 years; 47.9% men) were enrolled. After adjustment, older women with T2DM had a higher odds of possible sarcopenia (OR = 2.07, 95% CI = 1.57–2.72). In women aged ≥ 70 years, both good and poor glycemic control were significantly correlated with possible sarcopenia (OR = 1.87 and 2.10; 95% CI = 1.16–3.04 and 1.43–3.07; p for trend &lt; 0.0001). T2DM patients with hypertension, ischemic heart disease (IHD), or depression showed increased sarcopenia association (OR = 1.71, 1.81, and 2.45, respectively). Poor glycemic control revealed increased odds of sarcopenia in those with hypertension (OR = 1.80) or IHD (OR = 2.42).</p><h3>Conclusions</h3><p>Glycemic control could be crucial in preventing possible sarcopenia, especially among older women with T2DM. Comorbid hypertension, IHD, or depression are significantly associated with sarcopenia in T2DM patients, particularly in the presence of poor glycemic control.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03159-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote monitoring in older adults with cancer, opportunities and challenges: a narrative review","authors":"Evelyne Liuu,&nbsp;Nicolò Matteo Luca Battisti,&nbsp;Angeline Galvin,&nbsp;Sarah Compton,&nbsp;Tania Kalsi,&nbsp;Marc Paccalin,&nbsp;Simon Valero,&nbsp;Pierre Soubeyran,&nbsp;Carly Welch","doi":"10.1007/s40520-025-03161-x","DOIUrl":"10.1007/s40520-025-03161-x","url":null,"abstract":"<div><h3>Background</h3><p>The ageing population has led to more cancer cases among older adults, who face higher risks of treatment-related adverse events, functional decline, and unplanned healthcare use. Traditional assessments like Eastern Cooperative Oncology Group and Karnofsky Performance Status lack sensitivity for this group, highlighting the need for new methods to monitor symptoms and functional changes in cancer care. This review examines remote monitoring technologies for older adults with cancer, focusing on their potential and challenges.</p><h3>Main body</h3><p>E-health tools such as electronic patient-reported outcomes (ePROs) and wearable devices enable continuous monitoring of symptoms, treatment toxicity, functional status, and adherence. Although benefits like fewer hospitalisations and better survival are shown in younger populations, evidence for older adults is limited. Early studies indicate these technologies are feasible and well-received by older patients but face barriers including digital literacy, cognitive and physical impairments, and healthcare system readiness. Devices like activity trackers and smartphones may detect functional decline and fall risk, though optimal intervention criteria remain unclear. Incorporating e-health into geriatric assessment and survivorship care could foster personalized, proactive management.</p><h3>Conclusion</h3><p>Remote monitoring technologies hold promise for enhancing symptom and functional assessment in older adults with cancer, supporting age-appropriate care. However, robust geriatric-specific evidence is lacking. Future research should address technological challenges, validate clinical thresholds, and assess long-term outcomes. Integrating these tools within multidisciplinary frameworks can improve care delivery throughout the cancer journey.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03161-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing mobile app design for older adults: systematic review of age-friendly design","authors":"Elahe Amouzadeh,&nbsp;Iman Dianat,&nbsp;Javad Faradmal,&nbsp;Mohammad Babamiri","doi":"10.1007/s40520-025-03157-7","DOIUrl":"10.1007/s40520-025-03157-7","url":null,"abstract":"<div><h3>Background</h3><p>With the rapid growth of mobile technology, ensuring accessibility and usability for older adults has become a critical concern. This systematic review evaluates existing age-friendly mobile app design research, identifying key usability barriers and effective strategies for improving accessibility.</p><h3>Methods</h3><p>This study reviews English-language research (Published between Jun. 2014 and Mar. 2025) on mobile applications for adults aged 60 + , focusing on user-centered design, usability testing, and age-friendly adaptations. It compares different levels of accessibility features and evaluates their impact on usability, satisfaction, and engagement across various settings. Studies were retrieved from four online databases (PubMed, Scopus, Web of Science, and IEEE Xplore).</p><h3>Results</h3><p>This systematic review initially reviewed 1,556 records. From these, 132 articles met the inclusion criteria. The findings highlight several essential design elements, including simplified navigation, enlarged text and touch targets, voice interaction, and error-tolerant interfaces. Participatory design methods enhanced usability and satisfaction, demonstrating the importance of co-designing applications with older users. However, challenges like cognitive overload, lack of digital literacy, and accessibility barriers persist.</p><h3>Conclusion</h3><p>The review emphasizes the need for future research on Artificial Intelligence-driven personalization, long-term usability studies, and culturally inclusive mobile applications. By integrating age-friendly design principles, developers can enhance digital inclusion, promote independence, and improve the overall well-being of older adults in an increasingly digital world.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03157-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term (current) aspirin use and sepsis-related delirium in elderly patients: a retrospective cohort study","authors":"Xin Liang,&nbsp;Lubin Sun,&nbsp;Na Jiang,&nbsp;Xinya Li,&nbsp;Tanjian Li,&nbsp;Jun Lyu,&nbsp;Yu Wang","doi":"10.1007/s40520-025-03152-y","DOIUrl":"10.1007/s40520-025-03152-y","url":null,"abstract":"<div><h3>Background</h3><p>Driven by the global aging trend, the prognosis of elderly patients with sepsis has garnered increasing attention. Sepsis-associated delirium (SAD), a common manifestation of elderly patients with sepsis, is frequently linked to poor clinical outcomes. Despite its prevalence, effective preventive measures remain lacking. Pharmacological interventions have emerged as promising components of a comprehensive strategy for the treatment and prevention of delirium. Among them, aspirin—renowned for its anti-inflammatory properties, affordability, and safety—may hold particular promise, given the central role of inflammation in the pathogenesis of both sepsis and delirium. Early initiation of anti-inflammatory therapy may offer a more effective approach to preventing SAD and enhancing patient outcomes.</p><h3>Aims</h3><p>To investigate the association between long-term (current) aspirin use and the incidence of SAD in elderly septic patients.</p><h3>Methods</h3><p>We extracted and analyzed data from 9145 elderly septic patients. The primary outcome, SAD, was analyzed using multivariable logistic regression to explore the correlation between long-term (current) aspirin use and the incidence of SAD. To ensure the robustness of the results, inverse probability of treatment weighting was used to adjust Intergroup relations. Finally, subgroup analyses were conducted.</p><h3>Results</h3><p>765 elderly septic patients were long-term (current) aspirin users, with a SAD incidence rate of 31.9% (244/765). In contrast, 8380 elderly septic patients without a history of long-term (current) aspirin use had a SAD incidence rate of 46.1% (3863/8380). After adjusting for 49 covariates, the multivariable logistic regression results showed that long-term (current) aspirin use was negatively associated with the risk of SAD (adjusted OR: 0.78, <i>p</i> &lt; 0.001). Even after balancing group differences through inverse probability treatment weighting, the results remained stable.</p><h3>Conclusions</h3><p>In elderly patients, long-term (current) aspirin use is negatively associated with the incidence of SAD and is also linked to improved clinical outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03152-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture","authors":"Varvara Chatzipetrou,&nbsp;Thierry Chevalley,&nbsp;Ivan Padlina,&nbsp;Marina Portela,&nbsp;Serge Ferrari,&nbsp;Emmanuel Biver","doi":"10.1007/s40520-025-03154-w","DOIUrl":"10.1007/s40520-025-03154-w","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background and aims\u0000 <p>The incidence of fragility fractures is increasing among community-dwelling postmenopausal women. Sarcopenia and obesity are significant risk factors for fractures, independent of osteoporosis. This study aims to investigate the prevalence of sarcopenia and obesity, as well as bone microstructure, according to osteoporotic status and fracture sites in older women with recent low-trauma fractures.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>This cross-sectional study included 135 community-dwelling postmenopausal women aged 65 and older, evaluated within six months of experiencing a low-trauma fracture (resulting from a fall from standing height or less) occurring at the humerus, proximal femur, vertebrae, pelvis, forearm, or ankle. Participants were recruited either prospectively through the Fracture Liaison Service (FLS) at the Bone Disease Department of Geneva University Hospitals (HUG) (<i>n</i> = 90) or retrospectively from the Geneva Retirees Cohort (GERICO) (<i>n</i> = 45). Bone mineral density (BMD) and body composition were assessed using dual-energy X-ray absorptiometry (DXA), muscle strength was measured by handgrip strength (HGS), and bone microstructure was evaluated using high-resolution peripheral quantitative computed tomography (HR-pQCT).</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results and discussion\u0000 <p>The prevalence of sarcopenia varied, with the overall prevalence across all definitions being 25%. It was significantly higher in osteoporotic women than in women with normal BMD (39% versus 6%, respectively, <i>p</i> = 0.014) and osteopenia (39% versus 20% respectively, <i>p</i> &lt; 0.05). The prevalence of obesity was 24%, with particularly high rates observed among women with normal BMD (61%) and those with ankle or humerus fractures (43%, and 38%, respectively). Notably, 33% of women with major osteoporotic fractures (MOF) presented with normal BMD and without sarcopenia or obesity.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusions\u0000 <p>A significant proportion of women with apparent low-trauma MOF does not have osteoporosis nor alterations of body composition (sarcopenia or obesity). The determinants of fracture risk in these women remain unclear and further investigations are required to better address secondary fracture prevention in this context.</p>\u0000 \u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03154-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}