Aging Clinical and Experimental Research最新文献

{"title":"Loneliness and social support in cardiovascular aging: a closer look at the reported positive correlation","authors":"Arman Abroumand Gholami,&nbsp;Karimova Mavluda,&nbsp;Dilovar Karshiyeva,&nbsp;Oybek Eshmamatov,&nbsp;Gulnoz Khasanova","doi":"10.1007/s40520-026-03438-9","DOIUrl":"10.1007/s40520-026-03438-9","url":null,"abstract":"<div><p>This correspondence offers a methodological reflection on the cross-sectional study by Darabi and colleagues, which examines loneliness and social support in older Iranian adults with cardiovascular disease. The study addresses an important gap in Middle Eastern aging research. However, the reported positive correlation between loneliness and social support invites closer methodological consideration. We invite readers to consider four methodological aspects: whether shared method variance may have influenced the observed correlation, why subgroup findings do not follow the reported trends, whether the instruments perform similarly in a low-literacy population, and what the cross-sectional design can, and cannot, tell us about directionality. These considerations suggest the observed association might benefit from further investigation with longitudinal designs and objective measures. We hope these reflections support the continued study of social health in aging populations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03438-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing disability-adjusted life years (DALY) from multiple medication use and multiple illnesses of older adults in rural Thailand","authors":"Warinmad Kedthongma,&nbsp;Suajin Kasawong,&nbsp;Nitikorn Phoosuwan,&nbsp;Wuttiphong Phakdeekul","doi":"10.1007/s40520-026-03435-y","DOIUrl":"10.1007/s40520-026-03435-y","url":null,"abstract":"<div><h3>Background</h3><p>Geriatric syndromes including polypharmacy and multimorbidity represent growing public health challenges in aging rural populations, yet their population-level burden remains poorly quantified in low- and middle-income countries.</p><h3>Objective</h3><p>This study aimed to quantify gross disease burden, expressed as disability-adjusted life years (DALYs), across 25 conditions in a large rural Thai older adult population. Particular emphasis was placed on polypharmacy, multimorbidity, and potentially inappropriate medications, alongside the identification of disease clustering patterns to inform integrated care planning.</p><h3>Methods</h3><p>Population-based cross-sectional study of 587,905 older adults (aged ≥ 60 years) from 46 secondary hospitals in the 8th Health Service Region of northeastern Thailand. DALYs were calculated using Global Burden of Disease 2017 methodology. Polypharmacy was defined as concurrent use of ≥ 5 unique active pharmaceutical ingredients (APIs) for ≥ 90 consecutive days, assessed over both 2-year and 3-year lookback windows. Multimorbidity was defined as ≥ 2 chronic conditions. Potentially inappropriate medications were assessed using 2019 American Geriatrics Society Beers Criteria and Thai Rational Drug Use (RDU) criteria. DALY estimates represent gross population-level burden attributable to each condition or syndrome, without adjustment for co-occurring conditions.</p><h3>Results</h3><p>Total disease burden was 48.4 million DALYs (8,240,612 DALYs per 100,000 population). Diabetes mellitus accounted for the highest burden (16,511,859 DALYs; 2,910,112 per 100,000), followed by hypertension (8,331,200 DALYs; 1,417,720 per 100,000). Polypharmacy affected 59.5% (<i>n</i> = 349,803) contributing 4,035,612 DALYs (686,408 per 100,000), with YLL comprising 54.3% of this burden. Multimorbidity affected 48.6% (<i>n</i> = 285,721) contributing 3,301,572 DALYs. Potentially inappropriate medications were present in 32.1% (<i>n</i> = 188,718). The most common disease clusters were diabetes, hypertension, renal failure and respiratorycardiovascular combinations.</p><h3>Conclusions</h3><p>Polypharmacy and multimorbidity represent substantial gross population-level burdens in rural Thai older adults. These findings apply specifically to older adults accessing outpatient services at secondary hospitals in the 8th Health Service Region and should not be generalized to the entire rural older adult population. High prevalence of potentially inappropriate medications indicates urgent need for medication optimization interventions. Diabetes emerges as the leading disease burden despite lower prevalence than hypertension, highlighting the importance of DALY-based priority setting. These gross DALY estimates should be interpreted as descriptive measures of population health loss associated with each condition, rather than causal or adjusted effect estimates.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03435-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory of frailty among the older people in a community setting: A cohort study from the Shizuoka Kokuho Database","authors":"Shiori Nishimura,&nbsp;Kazuki Morohoshi,&nbsp;Ryo Nakamaru,&nbsp;Hisateru Tachimori,&nbsp;Hiroyuki Yamamoto,&nbsp;Eiji Nakatani,&nbsp;Masato Takeuchi,&nbsp;Yoshiki Miyachi,&nbsp;Shun Kohsaka,&nbsp;Hiroaki Miyata,&nbsp;Hiraku Kumamaru","doi":"10.1007/s40520-026-03434-z","DOIUrl":"10.1007/s40520-026-03434-z","url":null,"abstract":"<div><h3>Background</h3><p>Long-term population-level evidence on frailty trajectories, particularly among the oldest-old, remains limited.</p><h3>Aims</h3><p>To evaluate 6-year frailty trajectories in community-dwelling adults aged ≥ 50 years.</p><h3>Methods</h3><p>We conducted a cohort study using a regional Japanese administrative claims database from 2012 to 2020. Frailty was measured using the electronic Frailty Index. Inverse probability of censoring weighting accounted for insurance-plan disenrollment, and weighted multinomial logistic regression estimated adjusted 6-year transition probabilities.</p><h3>Results</h3><p>The cohort included 1,040,663 adults aged ≥ 50 years (mean age, 73.2 years; 58.6% women). Six-year final status worsened with baseline frailty severity: death increased from 12.7% among fit individuals to 23.8%, 34.7%, and 49.1% among those with mild, moderate, and severe frailty. Among those with severe frailty, recovery to fit status occurred in 2.6%, and recovery to fit or mild frailty in 9.0%; 91.0% died or were in moderate-to-severe frailty. Age- and sex-specific patterns differed. Among fit adults aged 65–74 years, women had lower mortality than men (4.3% vs. 8.7%) and higher probabilities of being alive with mild or moderate frailty (26.6% vs. 21.8%; 6.1% vs. 4.9%). Among fit adults aged ≥ 85 years, death was the dominant final state, although women had lower mortality (53.9% vs. 59.0%) and higher fit status (21.7% vs. 18.8%).</p><h3>Discussion</h3><p>Severe frailty was rarely followed by recovery to fit or mild status. Sex differences in frailty trajectories varied across age groups.</p><h3>Conclusions</h3><p>These findings highlight severe frailty as a late high-risk state and may inform age- and sex-specific frailty risk stratification and care planning.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03434-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific body composition changes and muscle performance decline: a 5-year prospective study","authors":"Ling Wang,&nbsp;Yandong Liu,&nbsp;Wenshuang Zhang,&nbsp;Bo Hu,&nbsp;Kangkang Ma,&nbsp;Fengyun Zhou,&nbsp;Zitong Cheng,&nbsp;Qingyu Zhang,&nbsp;Xiaoguang Cheng,&nbsp;Yi Yuan,&nbsp;Giuseppe Guglielmi,&nbsp;Ling Oei","doi":"10.1007/s40520-026-03425-0","DOIUrl":"10.1007/s40520-026-03425-0","url":null,"abstract":"<div><h3>Objective</h3><p>The change of muscle performance plays an important role in sarcopenia. Our objective was to examine longitudinal changes in body composition in older individuals in relation to changes in physical performance.</p><h3>Methods</h3><p>120 individuals were recruited from the neighborhood of the hospital. Computed tomography (CT) scans, handgrip strength (HGS) and the Timed Up and Go test (TUG) were obtained at baseline and follow-up after 5 years. Changes in muscle cross-sectional area and muscle density and adipose area were evaluated. Associations of changes in body composition with changes in HGS and TUG were tested in logistic regression models after adjusting for baseline age, height, weight and type 2 diabetes.</p><h3>Results</h3><p>Among females, each decrease (per cm²) of anterior compartment of thigh muscle size was associated with a 101% decrease of HGS (95% confidence interval [CI], 1.10–3.67; <i>P</i> = 0.02) and an 121% longer TUG (95%CI, 1.16–4.24; <i>P</i> = 0.02). Among males, each decrease (per HU) of psoas major muscle density (OR, 0.37; <i>P</i> = 0.04) would decrease the risk of decreased HGS.</p><h3>Conclusions</h3><p>CT-based body composition changes, atrophy of thigh muscles in particular, are associated with loss of muscle strength and physical performance.</p><h3>Advances in knowledge</h3><p>Key findings include significant reductions in muscle size and density across multiple compartments (paraspinal, pelvic and thigh muscles), greater adipose tissue increase in females, and sex-specific associations between thigh muscle atrophy and declines in HGS and TUG performance. These results align with prior cross-sectional evidence of age-related sarcopenia but extend them by quantifying longitudinal changes and their functional consequences.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital-initiated community pharmacist medication review post-discharge","authors":"Louise Clarkson,&nbsp;Bernadette Pollard,&nbsp;Shu-Kay Ng,&nbsp;Eve Finn,&nbsp;Alfred K Lam,&nbsp;Tien K Khoo","doi":"10.1007/s40520-026-03416-1","DOIUrl":"10.1007/s40520-026-03416-1","url":null,"abstract":"<div><h3>Background</h3><p>Drug related problems (DRPs) are commonly encountered by elderly patients on discharge from hospital. Further research is needed into interventions for risk reduction.</p><h3>Aims</h3><p>To investigate DRPs post-discharge and assess the Australian hospital-initiated community pharmacist medication review (HIMR) service for benefit.</p><h3>Methods</h3><p>Retrospective analysis of the Ballina Hospital HIMR service from 20/02/2023 to 20/02/2024 was completed. Data included patients baseline demographics, discharge medications, time to HIMR, DRPs identified, actions taken, and pharmacists’ recommendations for medication changes.</p><h3>Results</h3><p>The study cohort (<i>n</i> = 143) had a mean age of 82.2 ± 10.9 years and were prescribed an average of 9.4 ± 4.0 regular medications with 6.0 ± 4.6 medication changes at discharge. The initial HIMR (HIMR1) was completed 7.6 ± 6.1 days (median: 6.0) post-discharge, identifying non-adherence in 43% and possible adverse drug reactions in 22% of patients. Eleven patients (7.7%) received pharmacist interventions of moderate/high significance. Eighty-three follow-up visits (HIMR2) were attended. The HIMR2 reports showed 18.8% of medication change recommendations suggested by the pharmacist at HIMR1 were implemented.</p><h3>Discussion</h3><p>Significant interventions at HIMR1 were more likely to be experienced by patients ≥ 80 years, when comorbidity increased and when patients were reviewed sooner. Although multiple DRPs were identified, medication change suggestions made at HIMR1 were infrequently actioned in primary care.</p><h3>Conclusions</h3><p>DRPs and non-adherence were common in the population reviewed. HIMR was valuable for resolving immediate DRPs and assisting medication management, especially when performed nearest discharge. Further optimisation of this service to strengthen engagement with primary care practitioners is recommended.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and human burden of respiratory syncytial virus in older adults: a narrative review with emphasis on Italian data","authors":"Nicola Veronese,&nbsp;Ligia Dominguez,&nbsp;Giovanni M. Giammanco,&nbsp;Pietro Giuseppe Innocenti,&nbsp;Ida Mancuso,&nbsp;Francesco Saverio Ragusa,&nbsp;Francesco Vitale,&nbsp;Mario Barbagallo","doi":"10.1007/s40520-026-03424-1","DOIUrl":"10.1007/s40520-026-03424-1","url":null,"abstract":"<div><p>Respiratory syncytial virus (RSV) is a well-known driver of bronchiolitis and hospital admissions in infants. It is also a major threat for adults aged ≥ 60 years, causing acute respiratory infection with substantial morbidity and mortality. Only recently RSV surveillance programs have been implemented in Europe. In Italy, InfluNet, which has monitored influenza-like illness since 2000, began systematic RSV surveillance in the 2022–2023 season, now integrated within the national RespiVirNet framework. Interest in the burden of RSV infection in older patients has increased rapidly, particularly with new preventive tools. This narrative review summarizes recent evidence on the epidemiology and clinical features of RSV in older people, focusing on Italian data. The burden associated with hospitalization, functional and cognitive sequelae is emphasized, and comparisons with influenza are made. Evidence shows that RSV plays a significant role in winter hospital admissions among older adults, often leading to complications and lingering functional deficits beyond discharge. Those with preexisting conditions are especially at risk, and recent findings point to potential associations with cognitive deterioration. Numerous studies reveal that the severity of RSV-related hospitalisations matches that seen with influenza. Although more robust and harmonized data are needed, current evidence supports implementing targeted prevention strategies to lessen the impact of RSV in older adults. An integrated approach—combining rapid and sensitive diagnostics, routine surveillance, and access to preventive measures such as immunisation, particularly for frail individuals—holds promise for reducing the burden of RSV infection and alleviating pressures on national health services.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03424-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)","authors":"","doi":"10.1007/s40520-026-03383-7","DOIUrl":"10.1007/s40520-026-03383-7","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03383-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“The sound of silence”: when the brain doesn’t hear","authors":"Elisa Martinelli,&nbsp;Pasqualina Sapone,&nbsp;Pietro Gareri,&nbsp;Massimiliano Massaia,&nbsp;Anna Abbaldo,&nbsp;Angelo Di Stefano,&nbsp;Filomena Padulo,&nbsp;Laura Schiara,&nbsp;Rosaria Carlucci,&nbsp;Enrico Maria Cotroneo,&nbsp;Ilaria Gareri,&nbsp;Antonino Maria Cotroneo","doi":"10.1007/s40520-026-03412-5","DOIUrl":"10.1007/s40520-026-03412-5","url":null,"abstract":"<div><p>Cognitive impairment is one of the leading causes of disability worldwide and it affects about 6.5% of the population over the age of 65. Hearing impairment is a significant health problem and a possible cause for dementia. Preventing hearing loss or at least correcting it by the use of acoustic prosthesis may reduce the onset of dementia in old age. Indeed, hearing loss has been proposed as a risk factor for dementia, even if the mechanisms that correlate the two diseases are not yet fully understood. It can accelerate existing mild cognitive impairment by increasing the cognitive burden and/or exhausting existing cognitive compensatory strategies, and it could also increase social isolation. Peripheral hearing impairments and Central Auditory Processing (CAP) dysfunction should both be evaluated. Indeed, although peripheral auditory function impairment is perhaps the primary pathological component of early age-related hearing loss (ARHL), CAP dysfunction becomes increasingly important in the later stages of ARHL. The assessment of peripheral hearing function includes self-reporting and some screening tests (such as the 10-item Hearing Handicap Inventory for the Elderly - Short Form), a first-level clinical assessment for hearing loss (such as spoken voice or finger friction tests), audiometric screening tests (portable audiometers, portable audio) and diagnostic audiometric tests (such as pure tone audiometry in a soundproof booth to test the acoustic threshold). The present article focuses on the possible connection between sensory deprivation and the development of cognitive impairment in late age. The use of hearing aids and cognitive training could help delay or prevent the onset of cognitive decline. Furthermore, the use of hearing aids can be an effective tool not only to minimize perceived disability in older individuals, but also to reduce the caregiver’s burden by improving the patients’ ability to communicate.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03412-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between time to urgent or emergency pacemaker implantation and entry into residential aged care or death in older adults","authors":"Diane Nguyen,&nbsp;Madeleine Landwehr,&nbsp;Caitlyn Taylor,&nbsp;Eng Sim,&nbsp;Stephen Bacchi,&nbsp;Graham S. Hillis,&nbsp;Leon Flicker,&nbsp;Carl Schultz,&nbsp;Lucy Kilshaw,&nbsp;Nikola Stoyanov,&nbsp;Jamie W. Bellinge","doi":"10.1007/s40520-026-03413-4","DOIUrl":"10.1007/s40520-026-03413-4","url":null,"abstract":"<div><h3>Background</h3><p>Older adults often require permanent pacemaker (PPM) insertion. Delays to PPM insertion may associate with poor health outcomes.</p><h3>Aims</h3><p>To investigate the association between delayed PPM insertion and adverse outcomes in older adults.</p><h3>Methods</h3><p>Patients aged ≥65 years who underwent non-elective inpatient PPM insertion at Royal Perth Hospital between April 2019 and January 2022 were included in this retrospective cohort study. The relationship between time from admission to PPM insertion (exposure) and death or residential aged care facility (RACF) admission was examined using Cox modelling.</p><h3>Results</h3><p>In 375 patients, with a mean age of 80.8±7.5 years, the median [25th – 75th ] duration from admission to PPM insertion was 47 [22–90] hours. Time from admission to PPM insertion (days) was associated with an increased risk of death at 1635 [1048–1931] days follow-up in univariate regression models (HR 1.05, 95% CI [1.03–1.07], <i>p</i> &lt; 0.001) and after adjusting for comorbidities, demographics, clinical presentation characteristics and number of inpatient complications (HR 1.03 [1.00–1.05], <i>p</i> = 0.027). Time from admission to PPM insertion was associated with an increased risk of RACF admission at 1789 [1546–2128] days follow-up in univariate (HR 1.03 [1.00–1.07], <i>p</i> = 0.049), but not in multivariable regression models (HR 1.00 [0.96–1.04], <i>p</i> = 0.92).</p><h3>Discussion</h3><p>These findings support the existing literature associating delays to medical intervention and poor health outcomes in older adults.</p><h3>Conclusion</h3><p>In older adults, prolonged time from admission to PPM insertion was associated with higher mortality. Future research is needed to determine if reducing time to PPM insertion may improve their health outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03413-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between frailty dimensions and quality of life in older adults with Type 2 diabetes Mellitus: A cross-sectional study","authors":"Dimitra Natsina,&nbsp;Fotini Malli,&nbsp;Maria Malliarou,&nbsp;Georgios Tsioumanis,&nbsp;Maria Saridi,&nbsp;Katerina Toska,&nbsp;Theodosios Paralikas","doi":"10.1007/s40520-026-03428-x","DOIUrl":"10.1007/s40520-026-03428-x","url":null,"abstract":"<div><h3>Introduction</h3><p>Frailty is increasingly recognized as a clinically relevant condition in older adults with Type 2 Diabetes Mellitus (T2DM), with important implications for functional outcomes and individualized care. This study examined the association between multidimensional frailty and quality of life in older adults with T2DM.</p><h3>Methods</h3><p>A cross-sectional study was conducted among 112 older adults aged ≥ 65 years in the Trikala Regional Unit, Central Greece. Frailty was assessed using the Tilburg Frailty Indicator (TFI), and quality of life was measured using the Older People’s Quality of Life Questionnaire (OPQOL-35). Overall quality of life was operationalized as the OPQOL-35 mean score. Pearson correlation analysis was performed to examine the association between quality of life and frailty components, and multiple linear regression analysis was used to examine independent associations with quality of life.</p><h3>Results</h3><p>The sample demonstrated a moderate level of frailty (<i>M</i> = 7.88, <i>SD</i> = 2.78), exceeding the established cut-off for frailty. Physical fatigue and upper limb weakness were the most frequently reported physical limitations. All frailty components (physical, psychological, and social) were significantly associated with poorer OPQOL-35 mean scores (<i>p</i> &lt; .01). The strongest correlation was observed for physical health-related problems (<i>r</i> = .690, <i>p</i> &lt; .001), followed by social (<i>r</i> = .582, <i>p</i> &lt; .001) and psychological components (<i>r</i> = .486, <i>p</i> &lt; .001). The regression model explained 77.2% of the variance in quality of life (<i>R</i>² = 0.772), with physical frailty emerging as the strongest associated factor (β = 0.459, <i>p</i> &lt; .001), followed by social (β = 0.303, <i>p</i> &lt; .001) and psychological components (β = 0.202, <i>p</i> = .005).</p><h3>Conclusions</h3><p>Frailty shows a strong multidimensional association with quality of life in older adults with T2DM. These findings highlight the importance of early frailty screening and support the implementation of individualized, multidisciplinary management strategies in primary care to preserve functional ability and overall well-being in this vulnerable population.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03428-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}