Aging Clinical and Experimental Research最新文献

{"title":"Causal factors for osteoarthritis risk revealed by mendelian randomization analysis","authors":"Qingfeng Luo,&nbsp;Shiyong Zhang,&nbsp;Qiyuan Yang,&nbsp;Yuyi Deng,&nbsp;Hengjing Yi,&nbsp;Xingsheng Li","doi":"10.1007/s40520-024-02812-9","DOIUrl":"10.1007/s40520-024-02812-9","url":null,"abstract":"<div><p>Osteoarthritis (OA), a prevalent chronic disease among the elderly, presents a complex pathogenesis and currently lacks effective treatment. Traditional observational studies are time-consuming, labor-intensive, susceptible to confounding factors, and cannot establish causal relationships. Mendelian randomization (MR) analysis, leveraging genetic variation to assess causal associations between exposures and outcomes, offers a cost-effective and efficient alternative. Over the past decade, large-scale genome-wide association studies have identified numerous genetic variants linked to OA risk factors, facilitating MR study design. In this review, we systematically identified 52 MR studies meeting specific criteria and evaluated their quality, exploring the impact of lifestyle, nutrition, comorbidities, circulating metabolites, plasma proteins, and other health factors on OA risk. We discuss the results and potential mechanisms of MR findings, addressing conflicting evidence based on existing literature and our prior research. With the ongoing expansion of genome-wide association data, we anticipate MR’s role in future OA studies to broaden, particularly in drug development research using targeted MR approaches. We thus aim for this paper to offer valuable insights for researchers and clinicians in related fields.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of detraining on neuromuscular function and structural adaptations following once- or twice-weekly eccentric resistance training in older adults","authors":"Brett A. Baxter,&nbsp;Anthony W. Baross,&nbsp;Declan J. Ryan,&nbsp;Anthony D. Kay","doi":"10.1007/s40520-024-02828-1","DOIUrl":"10.1007/s40520-024-02828-1","url":null,"abstract":"<div><h3>Background</h3><p>Eccentric resistance training elicits greater preservation of training-induced muscular adaptations compared with other training modalities, however the detraining profiles of different training dosages remain unknown.</p><h3>Aims</h3><p>To examine the detraining effects following once- or twice-weekly eccentric-specific resistance training in older adults.</p><h3>Methods</h3><p>Twenty-one older adults (age = 70.5 ± 6.0 year) completed a 12-week detraining period following the 12-week eccentric training programmes with neuromuscular function and muscle structure assessed six (mid-detraining) and 12 (post-detraining) weeks following training cessation.</p><h3>Results</h3><p>From post-training to post-detraining, no significant regression of the training-induced improvements (collapsed group data reported) occurred in power (0%), strength (eccentric = 0%, isometric = 39%), or explosive strength over numerous epochs (0–32%), resulting in values that remained significantly greater than at pre-training. However, significant regression in the improvements in muscle thickness (91%) and fascicle angle (100%) occurred, resulting in values that were not significantly greater than pre-training.</p><h3>Discussion</h3><p>The limited regression in neuromuscular function following a 12-week detraining period has important implications for supporting eccentric exercise prescription in older adults who often face periods of inactivity. However, further work is required to develop an effective maintenance dosage strategy that preserves improvements in muscle structure.</p><h3>Conclusions</h3><p>Eccentric resistance training elicits improvements in the neuromuscular function of older adults, which are sustained for at least 12 weeks after eccentric training cessation.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress hyperglycemia ratio and its influence on mortality in elderly patients with severe community-acquired pneumonia: a retrospective study","authors":"Lei Miao,&nbsp;Xiaozhu Shen,&nbsp;Zhiqiang Du,&nbsp;Jingxian Liao","doi":"10.1007/s40520-024-02831-6","DOIUrl":"10.1007/s40520-024-02831-6","url":null,"abstract":"<div><h3>Background</h3><p>Community-acquired pneumonia (CAP) is a significant health issue among the elderly, with severe cases (SCAP) having high mortality rates. This study assesses the predictive significance of the stress hyperglycemia ratio (SHR) in elderly SCAP patients and its impact on outcomes in both diabetic and non-diabetic patients.</p><h3>Methods and materials</h3><p>This retrospective study included 406 SCAP patients aged 65 or older from the Second People’s Hospital of Lianyungang (January 2020 to December 2023). Data collected included demographics, medical history, vital signs, and lab results. SHR was calculated from initial blood glucose and estimated average glucose (HbA1c). Statistical analyses, including Cox regression and Kaplan-Meier analysis, evaluated SHR’s impact on mortality. Mediation models explored the effects of neutrophil-lymphocyte ratio (NLR) and SHR.</p><h3>Results</h3><p>The 28-day mortality rate was 21.67%. Deceased patients had higher age, Charlson Comorbidity Index, procalcitonin, NLR, glucose, and SHR levels compared to survivors (<i>P</i> &lt; 0.05). Both SHR and NLR significantly increased mortality risk, particularly in non-diabetic patients. Combining NLR and SHR improved ROC AUC to 0.898, with 89.80% sensitivity and 81.10% specificity. Kaplan-Meier analysis showed higher cumulative survival for SHR &lt; 1.14, regardless of diabetes status (<i>P</i> &lt; 0.05). NLR mediated 13.02% of the SHR-survival relationship, while SHR mediated 14.06% of the NLR-survival relationship.</p><h3>Conclusion</h3><p>Elevated SHR is a significant mortality risk factor in elderly SCAP patients, independent of diabetes status. Stringent glucose control and careful monitoring of SHR may improve outcomes in elderly patients with acute respiratory conditions.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis","authors":"Xiaoran Wang,&nbsp;Wenjing Chen,&nbsp;Wenxia Zhao,&nbsp;Mingsan Miao","doi":"10.1007/s40520-024-02811-w","DOIUrl":"10.1007/s40520-024-02811-w","url":null,"abstract":"<div><h3>Background</h3><p>Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated.</p><h3>Objective</h3><p>This study was aimed to assess whether glaucoma increase the risk of dementia or cognitive impairment.</p><h3>Methods</h3><p>PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort or case-control studies were searched from inception to March 10, 2024. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to the risk of bias. Heterogeneity was rigorously evaluated using the <i>I</i>² test, while publication bias was assessed by visual inspection of the funnel plot and by Egger’ s regression asymmetry test. Subgroup analyses were applied to determine the sources of heterogeneity.</p><h3>Results</h3><p>Twenty-seven studies covering 9,061,675 individuals were included. Pooled analyses indicated that glaucoma increased the risk of all-cause dementia, Alzheimer’s disease, vascular dementia, and cognitive impairment. Subgroup analysis showed that the prevalence of dementia was 2.90 (95% CI: 1.45–5.77) in age ≥ 65 years and 2.07 (95% CI: 1.18–3.62) in age&lt;65 years; the incidence rates in female glaucoma patients was 1.46 (95% CI: 1.06-2.00), respectively, which was no statistical significance in male patients. Among glaucoma types, POAG was more likely to develop dementia and cognitive impairment. There were also differences in regional distribution, with the highest prevalence in the Asia region, while glaucoma was not associated with dementia in Europe and North America regions.</p><h3>Conclusion</h3><p>Glaucoma increased the risk of subsequent cognitive impairment and dementia. The type of glaucoma, gender, age, and region composition of the study population may significantly affect the relationship between glaucoma and dementia.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies","authors":"Justyna Godos,&nbsp;Agnieszka Micek,&nbsp;Walter Currenti,&nbsp;Carlotta Franchi,&nbsp;Andrea Poli,&nbsp;Maurizio Battino,&nbsp;Alberto Dolci,&nbsp;Cristian Ricci,&nbsp;Zoltan Ungvari,&nbsp;Giuseppe Grosso","doi":"10.1007/s40520-024-02823-6","DOIUrl":"10.1007/s40520-024-02823-6","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.</p><h3>Aims</h3><p>To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.</p><h3>Methods</h3><p>A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs).</p><h3>Results</h3><p>The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95% CI: 0.75, 0.90, <i>I</i>^<i>2</i> = 61.1%), dementia (RR = 0.82, 95% CI: 0.73, 0.93, <i>I</i>^<i>2</i> = 38.7%), and Alzheimer’s disease (RR = 0.80, 95% CI: 0.67, 0.96, <i>I</i>^<i>2</i> = 20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR = 0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ε4 allele status was mixed based on the outcome investigated.</p><h3>Conclusions</h3><p>Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer’s disease there is a need for further studies to improve the strength of evidence.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2024)","authors":"","doi":"10.1007/s40520-024-02766-y","DOIUrl":"10.1007/s40520-024-02766-y","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World congress on osteoporosis, osteoarthritis and musculoskeletal diseases 2024","authors":"","doi":"10.1007/s40520-024-02774-y","DOIUrl":"10.1007/s40520-024-02774-y","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02774-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis","authors":"Weichu Sun,&nbsp;Hui Xiao,&nbsp;Yayun Li","doi":"10.1007/s40520-024-02813-8","DOIUrl":"10.1007/s40520-024-02813-8","url":null,"abstract":"<div><h3>Background</h3><p>Previous observational studies indicated a complex association between frailty and arthritis.</p><h3>Aims</h3><p>To investigate the genetic causal relationship between the frailty index and the risk of common arthritis.</p><h3>Methods</h3><p>We performed a large-scale Mendelian randomization (MR) analysis to assess frailty index associations with the risk of common arthritis in the UK Biobank (UKB), and the FinnGen Biobank. Summary genome-wide association statistics for frailty, as defined by the frailty index, and common arthritis including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PSA), and ankylosing spondylitis (AS). The inverse-variance weight (IVW) method served as the primary MR analysis. Heterogeneity testing and sensitivity analysis were also conducted.</p><h3>Results</h3><p>Our results denoted a genetic association between the frailty index with an increased risk of OA, the odds ratio (OR)_IVW in the UKB was 1.03 (95% confidence interval [CI]: 1.01–1.05; <i>P</i> = 0.007), and OR_IVW was 1.55 (95% CI: 1.16–2.07; <i>P</i> = 0.003) in the FinnGen. For RA, the OR_IVW from UKB and FinnGen were 1.03 (1.01–1.05, <i>P</i> = 0.006) and 4.57 (1.35–96.49; <i>P</i> = 0.025) respectively. For PSA, the frailty index was associated with PSA (OR_IVW = 4.22 (1.21–14.67), <i>P</i> = 0.023) in FinnGen, not in UKB (<i>P</i> &gt; 0.05). However, no association was found between frailty index and AS (<i>P</i> &gt; 0.05). These results remained consistent across sensitivity assessments.</p><h3>Conclusion</h3><p>This study demonstrated a potential causal relationship that genetic predisposition to frailty index was associated with the risk of arthritis, especially RA, OA, and PSA, not but AS. Our findings enrich the existing body of knowledge on the subject matter.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and recent falls in adults 80 years and older living in the community: results from the ilSIRENTE Study","authors":"Stefano Cacciatore,&nbsp;Emanuele Marzetti,&nbsp;Riccardo Calvani,&nbsp;Anna Picca,&nbsp;Sara Salini,&nbsp;Andrea Russo,&nbsp;Matteo Tosato,&nbsp;Francesco Landi","doi":"10.1007/s40520-024-02822-7","DOIUrl":"10.1007/s40520-024-02822-7","url":null,"abstract":"<div><h3>Background</h3><p>Falls in older adults significantly impact overall health and healthcare costs. Intrinsic capacity (IC) reflects functional reserve and is an indicator of healthy aging.</p><h3>Aims</h3><p>To explore the association between IC and recent falls (≤ 90 days) in community-dwelling octogenarians from the Aging and Longevity in the Sirente geographic area (IlSIRENTE) study.</p><h3>Methods</h3><p>The Minimum Data Set for Home Care (MDS−HC) and supplementary questionnaires and tests were used to assess the five IC domains: locomotion, cognition, vitality, psychology, and sensory. Scores in each domain were rescaled using the percent of maximum possible score method and averaged to obtain an overall IC score (range 0−100).</p><h3>Results</h3><p>The study included 319 participants (mean age 85.5 ± 4.8 years, 67.1% women). Mean IC score was 80.5 ± 14.2. The optimal IC score cut-off for predicting the two-year risk of incident loss of at least one activity of daily living (ADL) was determined and validated in a subset of 240 individuals without ADL disability at baseline (mean age 84.7 ± 4.4 years, 67.1% women). Participants were then stratified into low (&lt; 77.6) and high (≥ 77.6) IC categories. Those with high IC (63.9%) were younger, more often males, and had lower prevalence of recent falls, disability, multimorbidity, and polypharmacy. Logistic regression models including IC as a continuous variable revealed a significant association between higher IC and lower odds of falls. This association was significant in the unadjusted (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.94–0.98, <i>p</i> &lt; 0.001), age- and sex-adjusted (OR 0.96, 95% CI 0.94–0.98, <i>p</i> &lt; 0.001), and fully adjusted models (OR 0.96, 95% CI 0.93–0.99, <i>p</i> = 0.003). When considering IC as a categorical variable, unadjusted logistic regression showed a strong association between high IC and lower odds of falls (OR 0.31, 95% CI 0.16–0.60, <i>p</i> &lt; 0.001). This association remained significant in both the age- and sex-adjusted (OR 0.30, 95% CI 0.15–0.59, <i>p</i> &lt; 0.001) and fully adjusted models (OR 0.33, 95% CI 0.16–0.82, <i>p</i> = 0.007). The locomotion domain was independently associated with falls in the unadjusted (OR 0.98, 95% CI 0.97–0.99, <i>p</i> &lt; 0.001), age- and sex-adjusted (OR 0.97, 95% CI 0.96–0.99, <i>p</i> &lt; 0.001), and fully adjusted model (OR 0.98, 95% CI 0.96–0.99, <i>p</i> &lt; 0.001).</p><h3>Discussion</h3><p>This is the first study using an MDS−HC-derived instrument to assess IC. Individuals with higher IC were less likely to report recent falls, with locomotion being an independently associated domain.</p><h3>Conclusions</h3><p>Lower IC is linked to increased odds of falls. Interventions to maintain and improve IC, especially the locomotion domain, may reduce fall risk in community-dwelling octogenarians.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of functional performance outcomes between oral patented crystalline glucosamine sulfate and platelet-rich plasma among knee osteoarthritis patients: a propensity score matching analysis","authors":"Chavarin Amarase,&nbsp;Aree Tanavalee,&nbsp;Srihatach Ngarmukos,&nbsp;Chotetawan Tanavalee,&nbsp;Nonn Jaruthien,&nbsp;Pakpoom Somrak,&nbsp;Saran Tantavisut","doi":"10.1007/s40520-024-02814-7","DOIUrl":"10.1007/s40520-024-02814-7","url":null,"abstract":"<div><h3>Background</h3><p>Among the medications used to treat knee osteoarthritis (OA), oral patented crystalline glucosamine sulfate (pCGS) and platelet-rich plasma (PRP) have become popular alternatives to painkillers or nonsteroidal anti-inflammatory drugs (NSAIDs). Although studies have shown that pCGS and PRP improve clinical outcomes, no study has compared outcomes between these optional treatments. We compared functional performance outcomes from baseline to the 1-year follow-up (FU) between oral pCGS and PRP in patients with knee OA.</p><h3>Materials and methods</h3><p>Three hundred eighty-two patients receiving oral pCGS and 122 patients receiving PRP injections were enrolled for a review of functional performance outcomes, including a five-time sit-to-stand test (5xSST), time up-and-go test (TUGT), and 3-minute walk distance test (3MWDT). The patients were followed up for one year. The pCGS group received 1500 mg daily, whereas the PRP group received 2 cycles of intra-articular injections at week 0 and week 6. Using propensity score matching based on age, sex, height, weight, BMI, and Kellgren and Lawrence (KL) classification, all three functional performance outcomes were compared between the baseline (pretreatment), 6-week, 12-week, 24-week, and 1-year FUs.</p><h3>Results</h3><p>With a ratio of 2:1 (pCGS: PRP), 204 patients in the pCGS group were matched with 102 patients in the PRP group. Compared with the baseline levels, the PRP group showed significant improvements in 5xSST and TUGT outcomes from 6 weeks and significant improvements in 3MWDT outcomes from 12 weeks, whereas the pCGS group showed significant improvements in TUGT outcomes from 6 weeks and significant improvements in 5xSST and 3MWDT outcomes from 12 weeks. At the 24-week and 1-year FU, both groups showed significant improvements in all three functional performance tests without adverse events.</p><h3>Conclusions</h3><p>Although the PRP group showed faster improvements in 5xSST outcomes at six weeks, from the 12-week to 1-year FU, both the pCGS and PRP groups showed significant improvements in 5xSST, TUGT, and 3MWDT outcomes. As the use of PRP is more complicated and invasive than the use of oral pCGS, the benefits and drawbacks of selecting PRP over pCGS in knee OA treatment should be examined.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}