Aging Clinical and Experimental Research最新文献

{"title":"Does a high body mass index remain a protective factor in hip fracture patients with hypertension and diabetes?","authors":"Zhening Guo,&nbsp;Weicheng Wu,&nbsp;Bo Lv,&nbsp;Yongtao Mao,&nbsp;Chang She,&nbsp;Wei Xu,&nbsp;Jun Gu,&nbsp;Liubing Li,&nbsp;Jie Pan","doi":"10.1007/s40520-025-03010-x","DOIUrl":"10.1007/s40520-025-03010-x","url":null,"abstract":"<div><h3>Background</h3><p>Body mass index (BMI) was used to classify overweight or obesity. The obesity paradox was observed in elderly hip fracture patients. However, obesity has been implicated as one of the major risk factors for hypertension and diabetes. This study aims to determine whether a high body mass index (BMI) remains a protective factor in hip fracture patients with comorbid hypertension or diabetes, and to identify the optimal BMI threshold that best supports motor function recovery.</p><h3>Methods</h3><p>This study included patients aged 65 years and older who have underwent hip fracture surgery. Harris Hip Score (HHS) was utilized to evaluate the functional recovery, the relationship between BMI and HHS was examined using both linear and generalized additive model (GAM). A threshold model was established with BMI of 24 kg/m² and the difference between the threshold model and the GAM was compared utilizing the likelihood ratio test (LRT).</p><h3>Results</h3><p>A total of 213 patients were enrolled in the study. A nonlinear relationship was identified between BMI and HHS in patients with either hypertension or diabetes and the HHS demonstrated a significant downward trend with increasing BMI. The LRT revealed no significant difference between the threshold effect model with a BMI value of 24 kg/m² and the GAM.</p><h3>Conclusions</h3><p>This study reveals that the protective effect of high BMI on postoperative motor function in hip fracture patients is significantly modulated by comorbidities. We recommend modulating the BMI to approximately 24 kg/m² for elderly patients with hip fractures and comorbid conditions such as hypertension and diabetes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03010-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further insights into influence factors of hypertension in older patients with obstructive sleep apnea syndrome: a model based on multiple centers","authors":"Libo Zhao,&nbsp;Xin Xue,&nbsp;Yinghui Gao,&nbsp;Weihao Xu,&nbsp;Zhe Zhao,&nbsp;Weimeng Cai,&nbsp;Dong Rui,&nbsp;Xiaoshun Qian,&nbsp;Lin Liu,&nbsp;Li Fan","doi":"10.1007/s40520-025-02986-w","DOIUrl":"10.1007/s40520-025-02986-w","url":null,"abstract":"<div><h3>Objective</h3><p>To construct a novel model or a scoring system to predict hypertension comorbidity in older patients with obstructive sleep apnea syndrome (OSAS).</p><h3>Methods</h3><p>A total of 1290 older patients with OSAS from six tertiary hospitals in China were enrolled. The sample was randomly divided into a modeling set (80%) and validation set (20%) using a bootstrap method. Binary logistic regression analysis was used to identify influencing factors. According to the regression coefficients, a vivid nomogram was drawn, and an intuitive score was determined. The model and score were evaluated for discrimination and calibration. The <i>Z</i>-test was utilized to compare the predictive ability between the model and scoring system.</p><h3>Results</h3><p>In the multivariate analysis, age, body mass index (BMI), apnea–hypopnea index (AHI), total bilirubin (TB), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG) were significant predictors of hypertension. The area under the receiver operating characteristic curve of the model in the modeling and validation sets was 0.714 and 0.662, respectively. The scoring system had predictive ability equivalent to that of the model. Moreover, the calibration curve showed that the risk predicted by the model and the score was in good agreement with the actual hypertension risk.</p><h3>Conclusions</h3><p>This accessible and practical correlation model and diagram can reliably identify older patients with OSAS at high risk of developing hypertension and facilitate solutions on modifying this risk most effectively.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02986-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study","authors":"Chunhua Liang,&nbsp;Xueqin Yan,&nbsp;Jing Tian,&nbsp;Yunzhu Yang,&nbsp;Xiaohua Xiao,&nbsp;Yaohui Huang,&nbsp;Tianfu Wang","doi":"10.1007/s40520-025-03001-y","DOIUrl":"10.1007/s40520-025-03001-y","url":null,"abstract":"<div><h3>Background</h3><p>Although blood-based biomarkers can be used to detect early Alzheimer’s disease (AD), population differences affect their clinical value in early diagnosis of the disease spectrum.</p><h3>Aims</h3><p>To examine the potential of plasma biomarkers to detect different stages along the AD continuum in a Chinese population.</p><h3>Methods</h3><p>We enrolled 113 adults from the Shenzhen community (53 cognitively unimpaired [CU], 45 with mild cognitive impairment [MCI], and 15 with AD). We used the single-molecule array technique to detect the levels of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated-tau181 (p-tau181), and performed <i>APOE</i> genotyping. We assessed the association between plasma biomarkers and cognitive scores, and used receiver operating characteristic curves to measure performance for early AD diagnosis.</p><h3>Results</h3><p>The plasma GFAP, NfL, and p-tau181 levels increased significantly in AD and were slightly higher in MCI than in CU (GFAP <i>p</i> = 0.811, NfL <i>p</i> = 0.909, p-tau181 <i>p</i> = 0.696). The plasma GFAP and p-tau181 levels negatively correlated with cognitive scores. Blood markers demonstrated higher performance in identifying AD than CU or MCI. Plasma p-tau181 displayed the highest diagnostic value for AD. Predictions of cognitive impairment were more robust when blood markers were combined with clinical indicators for AD (age, sex, body mass index, years of education, and <i>APOE ε4</i> carrier status).</p><h3>Discussion</h3><p>The expression of plasma GFAP, NfL, and p-tau181 increased in the AD continuum. Importantly, plasma p-tau181 could identify individuals with AD from the general population, with superior predictive performance when combined with age or sex.</p><h3>Conclusions</h3><p>Plasma biomarkers are useful screening indicators for early AD in Chinese adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03001-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and gender differences in health characteristics of older people with visual impairment","authors":"Salvatore Metanmo,&nbsp;Charnel Mbianda,&nbsp;Marie-Josiane Ntsama-Ebode,&nbsp;Callixte Kuate-Tegueu,&nbsp;Melanie Annick Magnerou,&nbsp;Nadine Simo,&nbsp;Antoine Gbessemehlan,&nbsp;Maturin Tabue-Teguo","doi":"10.1007/s40520-025-02998-6","DOIUrl":"10.1007/s40520-025-02998-6","url":null,"abstract":"<div><h3>Background</h3><p>Africa’s population is ageing, with an attendant increase in the number and duration of health problems such as visual impairment (VI). Few data are available from sub-Saharan Africa concerning age and gender differences in this population of people suffering from VI. The aim of this study was to examine age and gender differences in the health characteristics of older people with VI in Cameroon.</p><h3>Methods</h3><p>This was a cross-sectional study carried out in Douala, Cameroon, among people aged 55 and over. Participants had to be free of blindness, neurological disorders or other severe health problems. Sociodemographic and clinical variables were collected, including VI. We investigated differences between men and women in different age strata (&lt; 65, 65–75, &gt; 75 years) among people with VI.</p><h3>Results</h3><p>Among 403 participants, 356 (88.3%) had VI and, regardless of age group, there were significantly more women, who lived alone, were professionally active, overweight, had frailty syndrome and were less likely to drive a car. For other variables (education, chronic alcoholism, cognitive impairment, basic and instrumental activities of daily living, depression and falls), differences between men and women were only significant in certain age groups, with women generally at higher risk.</p><h3>Conclusion</h3><p>The prevalence of VI is high older (&gt; 55 years) adults in Cameroon, with clear differences between men and women. The oldest individuals, and women appear to be most vulnerable. The identification of at-risk groups/persons through this cross-sectional study should make it possible to adapt public health strategies to contribute to the WHO objective of healthy ageing.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02998-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia-related traits and risk of falls in older adults: results from meta-analysis of cohort studies and Mendelian randomization analyses","authors":"Haohan Yang,&nbsp;Yu Jiang,&nbsp;Dingfa Liang,&nbsp;Chang Yang,&nbsp;Kaihua Qin,&nbsp;Yong Xie,&nbsp;Licheng Zhang,&nbsp;Peifu Tang,&nbsp;Xiang Cui,&nbsp;Houchen Lyu","doi":"10.1007/s40520-025-02997-7","DOIUrl":"10.1007/s40520-025-02997-7","url":null,"abstract":"<div><h3>Background</h3><p>Observational studies examining sarcopenia-related traits and fall risk remain controversial. Herein, we conducted meta-analyses of cohort studies triangulated with Mendelian randomization (MR) analyses to examine the potential causality between sarcopenia-related traits and risk of falls in older adults.</p><h3>Methods</h3><p>Literature search across PubMed, Embase, and Cochrane Library was performed from inception to February 2023 to identify cohort studies examining sarcopenia-related traits (including hand strength, appendicular lean mass, and walking speed) and falls. We assessed the association between these traits and fall risk using random-effects models to calculate pooled odds ratios (OR) and 95% confidence intervals (CIs). MR analyses were conducted using summary statistics derived from the UK Biobank consortium for sarcopenia-related traits and FinnGen consortium for falls. The inverse-variance weighted method was used as primary analysis.</p><h3>Results</h3><p>Our meta-analysis included 34 cohort studies. The combined analysis of sarcopenia-related traits revealed a 33% reduced fall risk with each unit increase in walking speed (OR 0.67, 95% CI 0.54–0.84) and a 2% decrease with each unit increase in hand strength (OR 0.98, 95% CI 0.97–0.99). However, appendicular lean mass had no significant effect on falls. In the MR analyses, only walking speed was causally associated with falls (OR 0.64, 95% CI 0.48–0.84). Hand strength and appendicular lean mass showed no statistically significant causal effect on falls.</p><h3>Conclusion</h3><p>Evidence from meta-analysis and MR suggests a strong association between walking speed and fall risk in older adults. However, the relationship between hand strength, appendicular lean mass, and falls has not yet been established.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02997-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable sarcopenia and depressive symptoms in community-dwelling older adults: exploring the role of frailty and comorbidities","authors":"Emanuele Rocco Villani,&nbsp;Andrea Salerno,&nbsp;Federico Triolo,&nbsp;Laura Franza,&nbsp;Giulia Vaccari,&nbsp;Barbara Manni,&nbsp;Antonella Rita Vaccina,&nbsp;Lucia Bergamini,&nbsp;Vanda Menon,&nbsp;Davide Zaccherini,&nbsp;Andrea Fabbo","doi":"10.1007/s40520-025-03005-8","DOIUrl":"10.1007/s40520-025-03005-8","url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia is a syndrome characterized by the loss of skeletal muscle associated with reduced physical strength/performance and could be correlated with depression, that is the most frequent cause of emotional distress in old age and can reduce the quality of life of the older adults.</p><h3>Aim</h3><p>The aim of the present study is to evaluate the association between probable sarcopenia and depressive symptoms in older adults, and the impact of comorbidity and frailty on this association.</p><h3>Methods</h3><p>This cross-sectional study included community-dwelling older adults at their first geriatric evaluation. Probable sarcopenia was screened according to SARC-F. Clinically significant depressive symptoms (CSDS) were assessed according to the 5-items geriatric depression scale (GDS.) Frailty was determined through the CHSA-clinical frailty scale (CFS). Comorbidity burden was scored through the Cumulative Illness Rating Scale-Geriatric (CIRS-CI).</p><h3>Results</h3><p>We included 238 participants with a mean age of 82.4 (± 6.9) years of age, 152 (63.6%) participants were females. Probable sarcopenia was diagnosed in 131 (55.0%) participants, while CSDS were present in 186 (78.2%) participants. In the multiadjusted model, probable sarcopenia was associated with a higher likelihood of CSDS (OR 2.70, 95% CI 1.03–6.12). No significant interaction of frailty and CIRS were found on the association between probable sarcopenia and CSDS.</p><h3>Conclusions</h3><p>Sarcopenia and depressive symptomatology are highly co-occurring in geriatric patients, and this association may be independent of frailty and comordibity burden.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03005-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of elderly myocarditis (1992–2021) and projections of future disease burden trends","authors":"Weichun Wang,&nbsp;Xiaofeng Chen","doi":"10.1007/s40520-025-02979-9","DOIUrl":"10.1007/s40520-025-02979-9","url":null,"abstract":"<div><h3>Objective</h3><p>Geriatric myocarditis represents a significant public health concern, directly influencing overall health and potentially leading to various cardiac diseases. This study seeks to quantify the burden of geriatric myocarditis over three decades (1992–2021) and provide forecasts for future disease burden.</p><h3>Methods</h3><p>Data on geriatric myocarditis from 1992 to 2021 was obtained from the Global Burden of Disease study, offering insights into the incidence of the condition, categorized by gender. The Joinpoint regression model was utilized to identify shifts in epidemiological trends, while decomposition analysis helped identify the underlying factors contributing to these trends. To project future incidence, deaths and DALYs (Disability-Adjusted Life Years), the Norpred and Bayesian Age-Period-Cohort (BAPC) models were employed.</p><h3>Results</h3><p>In 2021, the global ASIR (per 100,000) of elderly myocarditis was 47.57 (27.52–73.08), with 505,147 (292,319–774,561) cases. Age-standardized deaths(per 100,000) were 2.07 (1.55–2.51), totaling 20,718 (15,525–25,085) deaths, and age-standardized DALYs(per 100,000) were 29.77 (22.60–35.81), with 308,101 (234,226–370,674) DALYs. Greenland, Canada, and Austria had the highest ASIR(per 100,000), while Romania, Kazakhstan, and Croatia had the highest age-standardized deaths(per 100,000), and Romania, Kazakhstan, and Guyana had the highest age-standardized DALYs(per 100,000). Joinpoint Regression analysis revealed a recent upward trend in global incidence after a previous decline, consistent across genders and SDI regions. Deaths and DALYs showed declining trends globally, though male deaths recently increased. Decomposition analysis identified population growth and aging as key drivers of increased cases, deaths, and DALYs. Based on the nordpred model, by 2045, the global ASIR(per 100,000) is predicted to be 47.27, with 1,005,593 cases, age-standardized deaths(per 100,000) of 2.02, totaling 48,501 deaths, and age-standardized DALYs(per 100,000) of 26.21, with 595,694 DALYs. The BAPC model predicts a global ASIR(per 100,000) of 51.82, with 1,091,195 cases, age-standardized deaths(per 100,000) of 3.67, totaling 87,145 deaths, and age-standardized DALYs(per 100,000) of 49.09, with 1,084,738 DALYs.</p><h3>Conclusion</h3><p>As of 2021, the ASIR(per 100,000) of myocarditis in the elderly population showed a decline compared to 1992; however, a recent upward trend has been identified. Considering ongoing population growth, the number of myocarditis cases among the elderly is anticipated to increase.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02979-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characteristics of older adults with type 2 diabetes mellitus living in French Caribbean nursing homes: results from the baseline KASEHPAD study","authors":"Maturin Tabué-Teguo,&nbsp;Nadine Simo,&nbsp;Christine Rambhojan,&nbsp;Laurys Letchimy,&nbsp;Michel Bonnet,&nbsp;Fritz-Line Vélayoudom,&nbsp;Denis Boucaud-Maitre","doi":"10.1007/s40520-025-03008-5","DOIUrl":"10.1007/s40520-025-03008-5","url":null,"abstract":"<div><h3>Background</h3><p>The management of older adults with type 2 diabetes mellitus (T2DM) has not been previously assessed in nursing homes within the Caribbean region.</p><h3>Aims</h3><p>To investigate the prevalence of T2DM among residents of French Caribbean nursing homes and to characterize their health and functional status.</p><h3>Methods</h3><p>This cross-sectional study is based on baseline screening data from the KASEHPAD (Karukera Study of Ageing in Nursing Homes) cohort. Clinical characteristics and standard geriatric parameters were systematically collected and analyzed. Hemoglobin A1c (HbA1c) levels of older adults with diabetes were retrospectively extracted from patient records.</p><h3>Results</h3><p>A total of 332 participants aged 60 years or older were recruited from six nursing homes between September 2020 and November 2022. The prevalence of T2DM among residents was 28.3% (95% CI: 23.5–33.2). Among older adults with T2DM, 85.1% had hypertension, 17.1% had heart failure, and 24.1% had a history of stroke. The mean HbA1c level was 7.32 ± 1.5%. Of the 35 individuals (42.7%) with HbA1c &lt; 7%, 19 (54.3%) were receiving antidiabetic medications. Multivariate analysis identified HbA1c as the sole factor significantly associated with antidiabetic medication use (OR: 1.76, 95% CI: 1.12–3.04).</p><h3>Discussion</h3><p>Older adults with T2DM residing in French Caribbean nursing homes exhibit a high prevalence of cardiovascular risk factors and are at risk of overtreatment. The management of T2DM in this population appears to be driven primarily by blood glucose levels.</p><h3>Conclusion</h3><p>As the prevalence of older adults with T2DM is expected to rise in the Caribbean region, this trend will present significant challenges in delivering tailored care within future nursing home settings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03008-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant intervention to possibly delay disease progression and frailty in elderly idiopathic pulmonary fibrosis patients: a clinical trial","authors":"Hongyan Ren,&nbsp;Zheng Wang,&nbsp;Yafen Jiang,&nbsp;Qing Mu,&nbsp;Yaxin Li,&nbsp;Jing Wang,&nbsp;Tiantian Cui,&nbsp;Qijie Sun,&nbsp;Xiaojv Zhang","doi":"10.1007/s40520-025-03009-4","DOIUrl":"10.1007/s40520-025-03009-4","url":null,"abstract":"<div><h3>Background</h3><p>Idiopathic pulmonary fibrosis (IPF) is more likely to occur in the elderly population, and these patients often become depressed. It has been recognized that psychological disorders are not conducive to the control of many diseases. Thus, this study aims to determine whether alleviating depression can delay the progression of IPF and frailty in elderly patients with IPF.</p><h3>Methods</h3><p>IPF patients over 60 years old were included in the study. None had a prior history of psychological disorders. All developed depression after being diagnosed with IPF. During the 12-month follow-up, some patients received anti-depression interventions and the rest didn’t. Depression, IPF, frailty and peripheral inflammation at baseline and after follow-up were evaluated by indicators and scales such as BDI-II, FVC %pred, 6MWT, mMRC, CFS, TFI, SGRQ, K-BILD, IL-6, and TNF-α. Multivariate logistic regression was employed for data analysis.</p><h3>Results</h3><p>There were 213 elderly patients with IPF. Among the 89 patients who received anti-depression interventions, the above-mentioned indicators and scales did not deteriorate during the follow-up period (P &gt; 0.05). Among the remaining 124 patients, the FVC %pred, and 6MWT levels decreased, and the mMRC grade, CFS, TFI, SGRQ and K-BILD scores, and peripheral IL-6 and TNF-α levels increased during the follow-up period (P &lt; 0.05).</p><h3>Discussion</h3><p>Compared with non-intervened IPF patients, those receiving anti-depression interventions seemed to maintain a certain stability in IPF, frailty, and peripheral inflammation over a period.</p><h3>Conclusion</h3><p>Improving depression may help delay the deterioration of patients' IPF and frailty at certain stages.</p><p>Trial registration: Registration on UMIN-CTR. Registration number: UMIN000057161. Date of registration: February 27th, 2025.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03009-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anemia-related mortality trends in US older subjects, 1999 to 2019","authors":"Marco Zuin,&nbsp;Luigi Ferrucci,&nbsp;Giovanni Zuliani","doi":"10.1007/s40520-025-02982-0","DOIUrl":"10.1007/s40520-025-02982-0","url":null,"abstract":"<div><h3>Background</h3><p>Previous investigations showed that the prevalence of iron deficiency is increasing in United States (US). However, data regarding iron deficiency anemia-related mortality trends are lacking. We assess the trends in iron deficiency anemia-related mortality in US adults aged 65 years or older over the last two decades.</p><h3>Methods</h3><p>Iron-deficiency anemia-related deaths were ascertained using ICD-10 codes in the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2019. Age-adjusted mortality rates (AAMRs) were assessed using the Joinpoint regression modelling and expressed as estimated average annual percentage change (AAPC) and annual percent change (APC) with relative 95% confidence interval (95% CI), stratified by level of urbanization, sex, age, and race.</p><h3>Results</h3><p>Between 1999 and 2019, 30,540 US subjects aged ≥ 65 years old (11,986 men and 18,554 women) equating to 77.8 deaths per 100,000 or 27.9 deaths per week, had iron deficiency anemia listed as a cause of death. The AAMR remained stable from 1999 to 2013 [APC: -0.3, (95%CI: -0.9 to 0.1, <i>p</i> = 0.11)] and then sharply increased from 2013 to 2019 [APC: +9.7% (95%CI: 7.8 to 11.6), <i>p</i> &lt; 0.0001) without differences in sex, race, ethnicity or level of urbanization. The higher AAMRs were clustered in the Midwest [4.29 per 100,000 (95% CI: 4.20 to 4.38)] and in the South [3.35 per 100,000, 95% CI: 3.28 to 3.35)].</p><h3>Conclusions</h3><p>Over the last two decades the iron deficiency anemia-related mortality trends increased among US older subjects, without differences by sex, race, ethnicity or urbanicity.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02982-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}