Aging Clinical and Experimental Research最新文献

筛选
英文 中文
Recommendations for the optimal use of bone forming agents in osteoporosis 关于在骨质疏松症中优化使用骨形成剂的建议。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-09 DOI: 10.1007/s40520-024-02826-3
Nicola Veronese, Karine Briot, Nuria Guañabens, Ben Hur Albergaria, Majed Alokail, Nasser Al-Daghri, Angie Botto-van Bemden, Olivier Bruyère, Nansa Burlet, Cyrus Cooper, Elizabeth M. Curtis, Peter R. Ebeling, Philippe Halbout, Eric Hesse, Mickaël Hiligsmann, Bruno Muzzi Camargos, Nicholas C. Harvey, Adolfo Diez Perez, Régis Pierre Radermecker, Jean-Yves Reginster, René Rizzoli, Heide Siggelkow, Bernard Cortet, Maria Luisa Brandi
{"title":"Recommendations for the optimal use of bone forming agents in osteoporosis","authors":"Nicola Veronese,&nbsp;Karine Briot,&nbsp;Nuria Guañabens,&nbsp;Ben Hur Albergaria,&nbsp;Majed Alokail,&nbsp;Nasser Al-Daghri,&nbsp;Angie Botto-van Bemden,&nbsp;Olivier Bruyère,&nbsp;Nansa Burlet,&nbsp;Cyrus Cooper,&nbsp;Elizabeth M. Curtis,&nbsp;Peter R. Ebeling,&nbsp;Philippe Halbout,&nbsp;Eric Hesse,&nbsp;Mickaël Hiligsmann,&nbsp;Bruno Muzzi Camargos,&nbsp;Nicholas C. Harvey,&nbsp;Adolfo Diez Perez,&nbsp;Régis Pierre Radermecker,&nbsp;Jean-Yves Reginster,&nbsp;René Rizzoli,&nbsp;Heide Siggelkow,&nbsp;Bernard Cortet,&nbsp;Maria Luisa Brandi","doi":"10.1007/s40520-024-02826-3","DOIUrl":"10.1007/s40520-024-02826-3","url":null,"abstract":"<div><p>Bone forming agents, also known as anabolic therapies, are essential in managing osteoporosis, particularly for patients at very high-risk of fractures. Identifying candidates who will benefit the most from these treatments is crucial. For example, this group might include individuals with severe osteoporosis, multiple vertebral fractures, a recent fragility fracture or those unresponsive to antiresorptive treatments. Definitions of patients with a very high fracture risk vary across nations, are often based on fracture history, bone mineral density (BMD), and/or fracture risk calculated by FRAX® or other algorithms. However, for very high-risk patients, anabolic agents such as teriparatide, abaloparatide, or romosozumab are commonly recommended as first-line therapies due to their ability to stimulate new bone formation and improve bone microarchitecture, offering significant benefits in rapid fracture reduction over antiresorptive therapies. The cost-effectiveness of these agents is a critical consideration for decision-makers. Despite their higher costs, their effectiveness in significantly reducing fracture risk and improving quality of life can justify the investment, especially when long-term savings from reduced fracture rates and associated healthcare costs are considered. Additionally, after completing a course of anabolic therapy, transitioning to antiresorptive agents like bisphosphonates or denosumab is crucial to maintain the gains in bone density and minimize subsequent fracture risks. This sequential treatment approach ensures sustained protection and optimal resource utilization. In summary, the effective use of bone forming agents in osteoporosis requires a comprehensive strategy that includes accurate patient identification, consideration of cost-effectiveness, and implementation of appropriate sequential treatments, ultimately maximizing patient outcomes and healthcare efficiency.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respond to the editor regarding “The investigation of effect on foot plantar massage on functional recovery in older adults with general surgery, randomized clinical trial” 就 "足底按摩对普通外科老年人功能恢复的影响调查,随机临床试验 "回复编辑。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-09 DOI: 10.1007/s40520-024-02801-y
Asuman Saltan, Selda Mert, Önder Topbaş, Beyza Aksu
{"title":"Respond to the editor regarding “The investigation of effect on foot plantar massage on functional recovery in older adults with general surgery, randomized clinical trial”","authors":"Asuman Saltan,&nbsp;Selda Mert,&nbsp;Önder Topbaş,&nbsp;Beyza Aksu","doi":"10.1007/s40520-024-02801-y","DOIUrl":"10.1007/s40520-024-02801-y","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor’s note: Climate change and health in aging populations 编者按:气候变化与老龄人口的健康。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-09 DOI: 10.1007/s40520-024-02832-5
Nicola Veronese
{"title":"Editor’s note: Climate change and health in aging populations","authors":"Nicola Veronese","doi":"10.1007/s40520-024-02832-5","DOIUrl":"10.1007/s40520-024-02832-5","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to compensate for frailty? The real life impact of geriatric co-management on morbi-mortality after colorectal cancer surgery in patients aged 70 years or older 如何弥补虚弱?老年病学共同管理对 70 岁或 70 岁以上结直肠癌术后死亡率的实际影响。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-09 DOI: 10.1007/s40520-024-02752-4
A. Pille, H. Meillat, C. Braticevic, B. Lelong, F. Rousseau, M. Cecile, L. Tassy
{"title":"How to compensate for frailty? The real life impact of geriatric co-management on morbi-mortality after colorectal cancer surgery in patients aged 70 years or older","authors":"A. Pille,&nbsp;H. Meillat,&nbsp;C. Braticevic,&nbsp;B. Lelong,&nbsp;F. Rousseau,&nbsp;M. Cecile,&nbsp;L. Tassy","doi":"10.1007/s40520-024-02752-4","DOIUrl":"10.1007/s40520-024-02752-4","url":null,"abstract":"<div><p>In Europe, CRC is the second most common cause of cancer death, and surgery remains the mainstay curative treatment. Age and frailty are associated with an increased risk of postoperative morbidity and 1-year mortality. Chronological age is not sufficient to assess the risk of postoperative complications. The CGA has been developed to better identify frail patients. Geriatric co-management have been developed to optimize the post-operative outcomes. We analyzed the real-life of geriatric co-management within an ERAS program on surgical outcomes at 90 days and oncologic outcomes at 1 year in patients aged 70 years or older after surgery for CRC. This was a retrospective study based on a prospective cohort. Fifty-one patients with a G8 score ≤ 14 were referred to geriatricians for preoperative CGA (Frail Group). They were compared with 151 patients with a G8 score ≥ 15 (Robust Group). In the Frail Group, patients were significantly older with more comorbidities than the patients in the Robust Group. Oncologic characteristics, treatments and global post-operative outcomes were comparable between the two groups. One year after surgery mortality and recurrence rates were similar between the two groups. Our study suggests that geriatric co-management is feasible and contributes to the reduction of postoperative morbimortality. Moreover, performing the CGA after G8 score screening and completion of geriatric interventions resulted in similar 90-day postoperative outcomes, in frail patients than in robust patients. Our results confirmed the benefit of geriatric co-management, involving G8 screening, CGA, and ERAS, for frail older patients undergoing surgery for CRC.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of 24-hour movement behaviors with depressive symptoms in rural-dwelling older adults: a compositional data analysis 农村老年人 24 小时运动行为与抑郁症状的关联:构成数据分析。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-09 DOI: 10.1007/s40520-024-02827-2
Tong Zhao, Rui Liu, Qi Han, Xiaolei Han, Juan Ren, Ming Mao, Jie Lu, Lin Cong, Yongxiang Wang, Shi Tang, Yifeng Du, Chengxuan Qiu
{"title":"Associations of 24-hour movement behaviors with depressive symptoms in rural-dwelling older adults: a compositional data analysis","authors":"Tong Zhao,&nbsp;Rui Liu,&nbsp;Qi Han,&nbsp;Xiaolei Han,&nbsp;Juan Ren,&nbsp;Ming Mao,&nbsp;Jie Lu,&nbsp;Lin Cong,&nbsp;Yongxiang Wang,&nbsp;Shi Tang,&nbsp;Yifeng Du,&nbsp;Chengxuan Qiu","doi":"10.1007/s40520-024-02827-2","DOIUrl":"10.1007/s40520-024-02827-2","url":null,"abstract":"<div><h3>Background</h3><p>We aimed to explore the association of sleep duration with depressive symptoms among rural-dwelling older adults in China, and to estimate the impact of substituting sleep with sedentary behavior (SB) and physical activity (PA) on the association with depressive symptoms.</p><h3>Methods</h3><p>This population-based cross-sectional study included 2001 rural-dwelling older adults (age ≥ 60 years, 59.2% female). Sleep duration was assessed using the Pittsburgh Sleep Quality Index. We used accelerometers to assess SB and PA, and the 15-item Geriatric Depression Scale to assess depressive symptoms. Data were analyzed using restricted cubic splines, compositional logistic regression, and isotemporal substitution models.</p><h3>Results</h3><p>Restricted cubic spline curves showed a U-shaped association between daily sleep duration and the likelihood of depressive symptoms (<i>P</i>-nonlinear &lt; 0.001). Among older adults with sleep duration &lt; 7 h/day, reallocating 60 min/day spent on SB and PA to sleep were associated with multivariable-adjusted odds ratio (OR) of 0.81 (95% confidence interval [CI] = 0.78–0.84) and 0.79 (0.76–0.82), respectively, for depressive symptoms. Among older adults with sleep duration ≥ 7 h/day, reallocating 60 min/day spent in sleep to SB and PA, and reallocating 60 min/day spent on SB to PA were associated with multivariable-adjusted OR of 0.78 (0.74–0.84), 0.73 (0.69–0.78), and 0.94 (0.92–0.96), respectively, for depressive symptoms.</p><h3>Conclusions</h3><p>Our study reveals a U-shaped association of sleep duration with depressive symptoms in rural older adults and further shows that replacing SB and PA with sleep or vice versa is associated with reduced likelihoods of depressive symptoms depending on sleep duration.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of the onset of low handgrip strength in Europe: a longitudinal study of 42,183 older adults from 15 countries 欧洲低握力发病的预测因素:对 15 个国家 42,183 名老年人的纵向研究。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-07 DOI: 10.1007/s40520-024-02800-z
Rizwan Qaisar, M. Azhar Hussain, Fabio Franzese, Asima Karim, Firdos Ahmad, Atif Awad, Abeer A. Al-Masri, Shaea A. Alkahtani
{"title":"Predictors of the onset of low handgrip strength in Europe: a longitudinal study of 42,183 older adults from 15 countries","authors":"Rizwan Qaisar,&nbsp;M. Azhar Hussain,&nbsp;Fabio Franzese,&nbsp;Asima Karim,&nbsp;Firdos Ahmad,&nbsp;Atif Awad,&nbsp;Abeer A. Al-Masri,&nbsp;Shaea A. Alkahtani","doi":"10.1007/s40520-024-02800-z","DOIUrl":"10.1007/s40520-024-02800-z","url":null,"abstract":"<div><h3>Objectives</h3><p>A low handgrip strength (HGS) is a significant risk factor for multiple diseases. However, most relevant studies investigate the complications of a low HGS, while the risk potential of causative factors of low HGS remain poorly characterized.</p><h3>Methods</h3><p>We investigated the potentials of quality of life, depression, dyslipidaemia, diabetes mellitus, cancer, Alzheimer’s disease, stroke, frailty, and difficulties performing daily activities in predicting low HGS (≤ 27 kg for men, ≤ 16 kg for women) in European older adults aged 50 or above from 15 countries (n = 42,183). All data was collected from four successive waves of survey of health, ageing, and retirement in Europe (SHARE) conducted between 2013 and 2020. Logistic models are applied, and estimated effects are presented as odds ratios and probabilities.</p><h3>Results</h3><p>Collectively, 3016 participants (men; n = 1395; 7.38%, women; n = 1621, 6.97%) developed low HGS during the 6.5 years study period. After adjusting for covariables, we identified an advancing age (1.6–48.1% points higher risk of low HGS), male gender (1.0%-point higher risk of low HGS), lower quality of life (1.6%-point higher), and stroke (1.5%-points) as significant risk factors for low HGS. We also found a dose-dependent association of Euro-D depression scores with the risk of low HGS, as the higher scores were associated with between 0.6- and 2.3%-points higher risk of developing low HGS than participants without depression. Among physical performance indicators, difficulty climbing stairs (2.0%-points higher low HGS risk) or rising from a chair (0.7%-points) were significantly associated with developing low HGS. Lastly, frailty (0.9%-points higher risk of low HGS) and the fear of falling down (1.6%-points higher risk) also increased the risk of developing low HGS.</p><h3>Conclusion</h3><p>Altogether, we report several risk factors for developing low HGS. Our observations may help evaluating and monitoring high-risk population for developing low HGS in pre-clinical settings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extremity fractures, attempted suicide, blood transfusion and thromboembolic events are independent risk factors for a prolonged hospital stay in severely injured elderly 四肢骨折、自杀未遂、输血和血栓栓塞事件是导致重伤老人住院时间延长的独立风险因素。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-07 DOI: 10.1007/s40520-024-02817-4
Philipp Störmann, Jason A. Hörauf, Ramona Sturm, Lara Zankena, Jonin Serafin Zumsteg, Rolf Lefering, Ingo Marzi, Hans-Christoph Pape, Kai Oliver Jensen, TraumaRegister DGU
{"title":"Extremity fractures, attempted suicide, blood transfusion and thromboembolic events are independent risk factors for a prolonged hospital stay in severely injured elderly","authors":"Philipp Störmann,&nbsp;Jason A. Hörauf,&nbsp;Ramona Sturm,&nbsp;Lara Zankena,&nbsp;Jonin Serafin Zumsteg,&nbsp;Rolf Lefering,&nbsp;Ingo Marzi,&nbsp;Hans-Christoph Pape,&nbsp;Kai Oliver Jensen,&nbsp;TraumaRegister DGU","doi":"10.1007/s40520-024-02817-4","DOIUrl":"10.1007/s40520-024-02817-4","url":null,"abstract":"<div><h3>Methods</h3><p>Due to demographic change, the number of polytraumatized geriatric patients (&gt; 64 years) is expected to further increase in the coming years. In addition to the particularities of the accident and the associated injury patterns, prolonged inpatient stays are regularly observed in this group. The aim of the evaluation is to identify further factors that cause prolonged inpatient stays.</p><p>A study of the data from the TraumaRegister DGU® from 2016–2020 was performed. Inclusion criteria were an age of over 64 years, intensive care treatment in the GAS-region, and an Injury Severity Score (ISS) of at least 16 points. All patients who were above the 80th percentile for the average length of stay or average intensive care stay of the study population were defined as so-called long-stay patients. This resulted in a prolonged inpatient stay of &gt; 25 days and an intensive care stay of &gt; 13 days. Among other, the influence of the cause of the accident, injury patterns according to body regions, the occurrence of complications, and the influence of numerous clinical parameters were examined.</p><h3>Results</h3><p>A total of 23,026 patients with a mean age of 76.6 years and a mean ISS of 24 points were included. Mean ICU length of stay was 11 ± 12.9 days (regular length of stay: 3.9 ± 3.1d vs. prolonged length of stay: 12.8 ± 5.7d) and mean inpatient stay was 22.5 ± 18.9 days (regular length of stay: 20.7 ± 15d vs. 35.7 ± 22.3d). A total of n = 6,447 patients met the criteria for a prolonged length of stay. Among these, patients had one more diagnosis on average (4.6 vs. 5.8 diagnoses) and had a higher ISS (21.8 ± 6 pts. vs. 26.9 ± 9.5 pts.)</p><p>Independent risk factors for prolonged length of stay were intubation duration greater than 6 days (30-fold increased risk), occurrence of sepsis (4x), attempted suicide (3x), presence of extremity injury (2.3x), occurrence of a thromboembolic event (2.7x), and administration of red blood cell concentrates in the resuscitation room (1.9x).</p><h3>Conclusions</h3><p>The present analysis identified numerous independent risk factors for significantly prolonged hospitalization of the geriatric polytraumatized patient, which should be given increased attention during treatment. In particular, the need for a smooth transition to psychiatric follow-up treatment or patient-adapted rehabilitative care for geriatric patients with prolonged immobility after extremity injuries is emphasized by these results.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A transitional care program in a technologically monitored in‐hospital facility reduces the length of hospital stay and improves multidimensional frailty in older patients: a Randomized Clinical Trial 医院内技术监控设施中的过渡性护理计划可缩短住院时间并改善老年患者的多维度虚弱状况:随机临床试验。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-06 DOI: 10.1007/s40520-024-02821-8
Alberto Pilotto, Wanda Morganti, Marina Barbagelata, Emanuele Seminerio, Simona Morelli, Romina Custureri, Simone Dini, Barbara Senesi, Camilla Prete, Gianluca Puleo, Carlo Berutti Bergotto, Francesco Vallone, Carlo Custodero, Antonio Camurri, The PRO‐HOME Project Investigators Group
{"title":"A transitional care program in a technologically monitored in‐hospital facility reduces the length of hospital stay and improves multidimensional frailty in older patients: a Randomized Clinical Trial","authors":"Alberto Pilotto,&nbsp;Wanda Morganti,&nbsp;Marina Barbagelata,&nbsp;Emanuele Seminerio,&nbsp;Simona Morelli,&nbsp;Romina Custureri,&nbsp;Simone Dini,&nbsp;Barbara Senesi,&nbsp;Camilla Prete,&nbsp;Gianluca Puleo,&nbsp;Carlo Berutti Bergotto,&nbsp;Francesco Vallone,&nbsp;Carlo Custodero,&nbsp;Antonio Camurri,&nbsp;The PRO‐HOME Project Investigators Group","doi":"10.1007/s40520-024-02821-8","DOIUrl":"10.1007/s40520-024-02821-8","url":null,"abstract":"<div><h3>Background</h3><p>Longer length of hospital stay (LOS) negatively affects the organizational efficiency of public health systems and both clinical and functional aspects of older patients. Data on the effects of transitional care programs based on multicomponent interventions to reduce LOS of older patients are scarce and controversial.</p><h3>Aims</h3><p>The PRO‐HOME study aimed to assess the efficacy in reducing LOS of a transitional care program involving a multicomponent intervention inside a technologically monitored in‐hospital discharge facility.</p><h3>Methods</h3><p>This is a Randomized Clinical Trial on 60 patients (≥65 years), deemed stable and dischargeable from the Acute Geriatrics Unit, equally assigned to the Control Group (CG) or Intervention Group (IG). The latter underwent a multicomponent intervention including lifestyle educational program, cognitive and physical training. At baseline, multidimensional frailty according to the Multidimensional Prognostic Index (MPI), and Health‐Related Quality of Life (HRQOL) were assessed in both groups, along with physical capacities for the IG. Enrolled subjects were evaluated after 6 months of follow‐up to assess multidimensional frailty, HRQOL, and re‐hospitalization, institutionalization, and death rates.</p><h3>Results</h3><p>The IG showed a significant 2‐day reduction in LOS (median days IG = 2 (2–3) vs. CG = 4 (3–6); <i>p</i> &lt; 0.001) and an improvement in multidimensional frailty at 6 months compared to CG (median score IG = 0.25(0.25–0.36) vs. CG = 0.38(0.31–0.45); <i>p</i> = 0.040). No differences were found between the two groups in HRQOL, and re‐hospitalization, institutionalization, and death rates.</p><h3>Discussion</h3><p>Multidimensional frailty is a reversible condition that can be improved by reduced LOS.</p><h3>Conclusions</h3><p>The PRO‐HOME transitional care program reduces LOS and multidimensional frailty in hospitalized older patients.</p><p><i>Trial registration</i>: ClinicalTrials.gov n. NCT06227923 (retrospectively registered on 29/01/2024).</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of nutrition status and analysis of 180-day readmission factors in elderly hospitalized patients with COPD 慢性阻塞性肺病老年住院患者的营养状况调查和 180 天再入院因素分析。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-01 DOI: 10.1007/s40520-024-02820-9
Huan Liu, Jingsi Song, Zhiqiang Wang, Songze Wu, Shi Qiu, Benhui Chen, Zhiyong Rao, Xiaofan Jing
{"title":"Investigation of nutrition status and analysis of 180-day readmission factors in elderly hospitalized patients with COPD","authors":"Huan Liu,&nbsp;Jingsi Song,&nbsp;Zhiqiang Wang,&nbsp;Songze Wu,&nbsp;Shi Qiu,&nbsp;Benhui Chen,&nbsp;Zhiyong Rao,&nbsp;Xiaofan Jing","doi":"10.1007/s40520-024-02820-9","DOIUrl":"10.1007/s40520-024-02820-9","url":null,"abstract":"<div><h3>Background and objective</h3><p>Malnutrition is prevalent among elderly patients with COPD, who also experience a high rate of readmission. Therefore, it is imperative to investigate the nutrition status of these patients, identify risk factors for readmission, and offer insights for clinical management. To achieve this, a cross-sectional study was conducted to investigate factors influencing nutrition status using GLIM criteria and explore the 180-day readmission factors among hospitalized elderly COPD patients.</p><h3>Methords and results</h3><p>The data were collected from a hospital in Southwest China, encompassing a cohort of 319 eligible patients. Among elderly hospitalized COPD patients, the prevalence of malnutrition was 49.53% (158/319). Multivariate logistic regression revealed malnutrition (OR = 3.184), very severe airway obstruction (OR = 3.735), and Number of comorbidities ≥ 3 (OR = 5.754) as significant risk factors for 180-day readmission.</p><h3>Conclusions</h3><p>These findings suggest that malnutrition is a prevalent issue among elderly hospitalized patients with COPD and constitutes one of the risk factors contributing to the 180-day readmission rate. Therefore, timely identification and treatment for malnourished patients are crucial.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meaning of home attenuates the relationship between functional limitations and active aging 家庭的意义削弱了功能限制与积极老龄化之间的关系。
IF 3.4 3区 医学
Aging Clinical and Experimental Research Pub Date : 2024-08-01 DOI: 10.1007/s40520-024-02810-x
Björn Slaug, Magnus Zingmark, Marianne Granbom, Jonas Björk, Taina Rantanen, Steven M. Schmidt, Susanne Iwarsson
{"title":"Meaning of home attenuates the relationship between functional limitations and active aging","authors":"Björn Slaug,&nbsp;Magnus Zingmark,&nbsp;Marianne Granbom,&nbsp;Jonas Björk,&nbsp;Taina Rantanen,&nbsp;Steven M. Schmidt,&nbsp;Susanne Iwarsson","doi":"10.1007/s40520-024-02810-x","DOIUrl":"10.1007/s40520-024-02810-x","url":null,"abstract":"<div><h3>Background and aims</h3><p>Active aging is the process through which people strive to maintain wellbeing when growing old. Addressing the lack of research on active aging in the context of housing, the aim was to describe active aging among people aged 55 and older considering relocation and investigate whether perceived housing moderates the relationship between functional limitations and active aging.</p><h3>Methods</h3><p>We utilized cross-sectional data from a sub-sample (<i>N</i> = 820; mean age = 69.7; 54% women) of the Prospective RELOC-AGE. Functional limitations were reported using 10 dichotomous questions. Active aging was assessed with the University of Jyvaskyla Active Aging Scale (UJACAS; 17 items, self-rated for four perspectives). Perceived housing was self-rated with four usability questions and meaning of home (MOH; 28 items). Cross-sectional associations and interactions were analysed using linear regression models, adjusting for gender and educational level.</p><h3>Results</h3><p>Each functional limitation decreased the active aging score by almost five points (<i>p</i> &lt; 0.001). Usability did not moderate that relationship while MOH significantly attenuated the association between functional limitations and active aging (<i>p</i> = 0.039). Those with high MOH had two points less decrease in active aging score compared to those with low MOH.</p><h3>Discussion and conclusions</h3><p>Having a home with more personal meaning attached to it seems to provide more ability and opportunity for meaningful activities, thus supporting active aging despite functional limitations. This sheds new light on the known association between MOH and different aspects of wellbeing in old age and has relevance for theory development, housing policies and housing counselling targeting younger older adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信