Aging Clinical and Experimental Research最新文献

{"title":"Urban health inequities and healthy longevity: traditional and emerging risk factors across the cities and policy implications","authors":"Stefano Cacciatore,&nbsp;Sofia Mao,&nbsp;Mayra Villalba Nuñez,&nbsp;Claudia Massaro,&nbsp;Luigi Spadafora,&nbsp;Marco Bernardi,&nbsp;Francesco Perone,&nbsp;Pierre Sabouret,&nbsp;Giuseppe Biondi-Zoccai,&nbsp;Maciej Banach,&nbsp;Riccardo Calvani,&nbsp;Matteo Tosato,&nbsp;Emanuele Marzetti,&nbsp;Francesco Landi","doi":"10.1007/s40520-025-03052-1","DOIUrl":"10.1007/s40520-025-03052-1","url":null,"abstract":"<div><p>Urbanization is reshaping global health, with over 55% of the world’s population residing in urban areas, a figure projected to reach 68% by 2050. This demographic shift presents significant challenges and opportunities for public health, as urban environments exacerbate health disparities rooted in social determinants of health, such as economic stability, education, neighborhood conditions, and access to healthcare. Rapid urban growth, particularly in low- and middle-income countries, has led to the emergence of inequitable living conditions, environmental hazards, and limited access to essential health services, contributing to the early onset of multimorbidity and rising non-communicable disease burdens. Urbanization-driven factors such as obesogenic environments, sedentary lifestyles, air pollution, and inadequate sleep exacerbate cardiovascular and metabolic risks, while social exclusion, overcrowding, and inadequate mental health services heighten vulnerabilities. Emerging risks, including urban heat islands, noise pollution, and exposure to endocrine-disrupting chemicals, further compound urban health inequities. Effective mitigation requires multi-sectoral policies that prioritize health-promoting infrastructure, reduce environmental pollutants, foster equitable healthcare access, and address systemic barriers affecting marginalized groups. This review explores the intersections between urbanization and health inequities, emphasizing the importance of addressing traditional and emerging risk factors across the lifespan. Policy implications include promoting green infrastructure, enhancing urban mobility, expanding mental health care, and leveraging participatory governance to foster resilient and inclusive cities. By adopting an integrated approach that prioritizes social equity and sustainability, cities can mitigate health disparities and create healthier, more inclusive urban environments that support the well-being of all residents.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03052-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calf circumference predicts changes of bone mineral density in postmenopausal osteoporotic women receiving denosumab","authors":"Cecilia Oliveri,&nbsp;Anastasia Xourafa,&nbsp;Nunziata Morabito,&nbsp;Adele Di Giovanni,&nbsp;Elisa Lupo,&nbsp;Giorgio Basile,&nbsp;Agostino Gaudio,&nbsp;Antonino Catalano","doi":"10.1007/s40520-025-02989-7","DOIUrl":"10.1007/s40520-025-02989-7","url":null,"abstract":"<div><h3>Background</h3><p>Aging is associated with deterioration of muscle and bone health, resulting in increased fragility fracture risk. It is not known whether muscle mass and strength could impact the osteoporosis pharmacological response.</p><h3>Aim</h3><p>The aim of this study was to analyze the association between muscle mass and strength with the response to denosumab in osteoporosis.</p><h3>Methods</h3><p>Postmenopausal women at high fracture risk receiving denosumab (60 mg subcutaneously administered every 6 months) were considered. The likelihood of sarcopenia was estimated by administering the SARC-F questionnaire, muscle mass and performance were assessed by measuring calf circumference (CC) and hand grip strength, respectively. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry.</p><h3>Results</h3><p>130 women (age 70.2 ± 9.4 years) were recruited. Baseline BMD T-score values were − 2.6 ± 1.1 SD and − 2.3 ± 0.7 SD at lumbar spine and femoral neck, respectively; while CC and grip strength were 31.9 ± 2.9 cm and 22.7 ± 6.7 kg, respectively. The SARC-F score was associated with the 10-year probability of major osteoporotic fracture (r = 0.21, p &lt; 0.05). The CC was positively associated with the T-score values of both lumbar spine (r = 0.262, p = 0.034) and femoral neck (r = 0.359, p = 0.004). Denosumab administration (treatment duration 43 months), lead to BMD improvement by + 9.6% at the lumbar spine and + 7.3% at the femoral neck (p^all &lt; 0.05). After adjustment for comorbidities, fracture risk and treatment duration, the CC (β = 1.76, SE = 0.82, p = 0.03) and the baseline femoral BMD (β = − 94.19, SE = 26.09, p = 0.0009) were independently associated with femoral BMD gain over time.</p><h3>Conclusion</h3><p>In postmenopausal osteoporotic women, the CC was positively and independently associated with denosumab treatment response.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02989-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of antidiabetic drugs for obese patients with knee osteoarthritis: a network meta-analysis of randomized controlled trials","authors":"Guangyao Jiang,&nbsp;Xiangyu Yang,&nbsp;Guanghui Zhu,&nbsp;Tang Liu","doi":"10.1007/s40520-025-03017-4","DOIUrl":"10.1007/s40520-025-03017-4","url":null,"abstract":"<div><h3>Background</h3><p>Obesity-related knee osteoarthritis (KOA) is a significant public health concern, affecting quality of life. Recent evidence suggests some antidiabetic drugs may help manage KOA in obese patients due to their anti-inflammatory and weight-reducing effects.</p><h3>Objective</h3><p>This study aimed to compare the efficacy and safety of antidiabetic drugs for managing pain and adverse events in obese KOA patients through a network meta-analysis of randomized controlled trials (RCTs).</p><h3>Methods</h3><p>A systematic search of multiple databases identified relevant RCTs on antidiabetic drugs for KOA. Treatment efficacy was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score improvement, and safety was evaluated based on the incidence of serious adverse events. The Surface Under the Cumulative Ranking Curve (SUCRA) scores were used to rank the treatments, and effect sizes were reported as mean differences (MD) with 95% confidence intervals (CI).</p><h3>Results</h3><p>A total of nine RCTs were included in the analysis. For pain relief, metformin demonstrated the largest effect size with a mean difference of − 1.13 (95% CI − 1.48, − 0.78) compared to usual care, followed by Metformin-Phosphatidylcholine (MFPH) (− 0.92, 95% CI − 1.70, − 0.13) and semaglutide (− 0.90, 95% CI − 1.48, − 0.32). In terms of safety, usual care exhibited the lowest risk of adverse events, with liraglutide (0.09, 95% CI − 0.74, 0.92) and semaglutide (0.21, 95% CI − 0.46, 0.88) also showing favorable safety profiles. The SUCRA rankings further supported these findings, with metformin ranking highest for efficacy (SUCRA: 86.8%) and usual care ranking highest for safety (SUCRA: 75.7%). However, these rankings should be interpreted alongside the effect sizes and clinical context to fully assess the trade-offs between efficacy and safety across interventions.</p><h3>Conclusions</h3><p>Metformin and MFPH are promising for managing KOA pain in obese patients. Semaglutide offers a balanced efficacy and safety profile, while liraglutide may be a safe option for selected patients. Further research is needed to confirm these findings and assess long-term outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03017-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social isolation, loneliness and the relationship with serum biomarkers, functional parameters and mortality in older adults","authors":"Stefanie Braig,&nbsp;Michael D. Denkinger,&nbsp;Dhayana Dallmeier,&nbsp;Jochen Klenk,&nbsp;Dietrich Rothenbacher,&nbsp;for the ActiFE Study Group","doi":"10.1007/s40520-025-03041-4","DOIUrl":"10.1007/s40520-025-03041-4","url":null,"abstract":"<div><h3>Background</h3><p>Pathways between social isolation (SI), loneliness and health are unclear.</p><h3>Aims</h3><p>To analyze the relationship between SI and loneliness with biomarkers of inflammation, cardiac and immune function, functional parameters, and mortality.</p><h3>Methods</h3><p>SI (Lubben Social Network Scale) from family, friends, and overall as well as loneliness (single direct question) were assessed at baseline in a population-based cohort study of 1459 community-dwelling adults aged 65 + in Germany. Serum biomarkers and functional parameters measured at baseline and at three-year follow-up included high-sensitivity C reactive protein (hs-CRP), growth differentiation factor-15 (GDF-15), N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin I (hs-cTnI), high-sensitivity troponin T (hs-cTnT), gait speed, and hand grip strength. We used linear and Cox regression analyses adjusted for age and sex (model 1) and established confounders (model 2).</p><h3>Results</h3><p>High SI from friends was associated with small but significant adverse associations with some biomarkers (hs-CRP, GDF-15, hs-cTnT) at follow-up (model 1). High SI from family associated with NT-proBNP (model 2), high SI and moderate to severe loneliness with lower gait speed. Loneliness was linked to hs-CRP at baseline, but SI was a stronger predictor of biomarker levels. High SI overall (Hazard ratio 1.39, 95% CI 1.15; 1.67, model 2) was associated with increased 10-year mortality.</p><h3>Discussion</h3><p>Mainly SI from friends is linked to unfavorable biomarker profiles with small associations. Overall SI was negatively associated with functional parameters and positively with mortality.</p><h3>Conclusions</h3><p>Further research should confirm our findings using, e.g. a multidimensional assessment of loneliness.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03041-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood transfusion in older surgical patients: the only option or is there a better approach?","authors":"Mariagiovanna Cozza,&nbsp;Virginia Boccardi,&nbsp;Ruslan Duka,&nbsp;Yogesh Vashist,&nbsp;Luigi Marano","doi":"10.1007/s40520-025-03033-4","DOIUrl":"10.1007/s40520-025-03033-4","url":null,"abstract":"<div><p>Anemia is a common clinical condition that can significantly affect patient outcomes, particularly in those undergoing surgery. In older adults, the presence of anemia combined with cardiovascular disease can increase surgical morbidity and mortality, influencing surgical decisions and creating a cascade of complications that may negatively impact recovery. Blood transfusion remains the primary response to anemia in the perioperative setting, despite evidence suggesting potential adverse effects on survival and recovery. However, older adults present unique challenges due to age-related physiological changes anda reduced tolerance to anemia and blood loss. The debate between restrictive and liberal blood transfusion strategies in this population remains unresolved. Patient Blood Management (PBM) protocols have been developed to systematically address perioperative anemia. This review emphasizes the need for a nuanced approach to transfusion in older adults, suggesting that while a restrictive strategy may not be universally applicable, decisions should be guided by thorough clinical evaluations. These assessments should prioritize not only hemoglobin levels but also patient-specific factors, including life expectancy, comorbidities, and patient preferences, with the involvement of a multidisciplinary team to tailor the best approach for everyone.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03033-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of different dual task mode interventions on cognitive function in older adults with mild cognitive impairment or dementia: a systematic review and network meta-analysis","authors":"Yuqing Hao,&nbsp;Yajie Zhao,&nbsp;Huanhuan Luo,&nbsp;Lanying Xie,&nbsp;Huixiu Hu,&nbsp;Chao Sun","doi":"10.1007/s40520-025-03016-5","DOIUrl":"10.1007/s40520-025-03016-5","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate and compare the effects of different dual task interventions on cognitive function in older adults with cognitive impairment or dementia.</p><h3>Methods</h3><p>We searched eight databases, including PubMed, Cochrane Library, and EMBASE, to obtain studies exclusively comprising randomized controlled trials on dual task interventions in individuals aged 60 and older with mild cognitive impairment or dementia, up to July 28, 2024. Study quality was evaluated using the Cochrane Risk of Bias Tool. Analyses included pairwise meta-analyses via Review Manager 5.4 and network meta-analyses via Stata 14.0.</p><h3>Results</h3><p>A total of 32 RCTs involving 2370 participants were included. Dual cognitive task training had the most significant impact on global cognition (SUCRA = 79.2%, mean rank = 1.6) and motor-cognitive dual task training was the only dual task intervention with a notable improvement in executive function (SMD = 1.53, 95% CI 0.06–3.01). For physical function, dual motor task training was most effective, improving gait performance (SMD = 0.34), muscle strength (SMD = 0.28), and balance (SMD = 0.90). Motor-cognitive dual task training demonstrated the greatest effectiveness in enhancing activities of daily living (SMD = 1.50) and quality of life (SMD = 1.20), while reducing depressive symptoms (SMD = − 0.96).</p><h3>Conclusions</h3><p>Dual cognitive task training is the most effective dual task intervention for enhancing global cognition. Motor-cognitive dual task training is the only dual task mode that significantly improves executive cognition.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03016-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of extreme weather events on food security among older people: a systematic review","authors":"Daniele Nucci,&nbsp;Flavia Pennisi,&nbsp;Antonio Pinto,&nbsp;Emanuele De Ponti,&nbsp;Giovanni Emanuele Ricciardi,&nbsp;Carlo Signorelli,&nbsp;Nicola Veronese,&nbsp;Alberto Castagna,&nbsp;Stefania Maggi,&nbsp;Chiara Cadeddu,&nbsp;Vincenza Gianfredi","doi":"10.1007/s40520-025-03050-3","DOIUrl":"10.1007/s40520-025-03050-3","url":null,"abstract":"<div><h3>Background</h3><p>Climate change has intensified the frequency and severity of extreme weather events, disproportionately affecting vulnerable populations, including older people for which the literature is still limited. This systematic review investigated the impact of extreme weather events on malnutrition and food security among individuals aged 60 and older.</p><h3>Methods</h3><p>A systematic search of PubMed/MEDLINE, Scopus, and Web of Science was conducted without restrictions (October 2024), and following PRISMA guidelines. Observational studies examining older adults exposed to extreme weather events (e.g., droughts, floods, heatwaves, hurricanes) and their effects on malnutrition or food security were included. The Newcastle-Ottawa Scale assessed study quality. Protocol was registered in PROSPERO (ID: CRD42024596910).</p><h3>Results</h3><p>From 1,709 articles, six observational studies involving 265,000 participants (aged 60 years and over) were included. These studies spanned multiple geographies, with a concentration in the United States. Findings revealed a dual impact: while some studies reported protective factors, such as social support and economic stability, others highlighted increased malnutrition risk due to disrupted food supply, economic hardship, and inadequate adaptive responses. Heterogeneity in study designs, exposure definitions, and outcome measures limited comparability.</p><h3>Conclusion</h3><p>Extreme weather events significantly impact malnutrition and food security among older adults, with outcomes influenced by socio-economic and geographical factors. Further longitudinal studies are needed to clarify causal pathways and inform targeted public health interventions to enhance resilience in aging populations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03050-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease","authors":"Shiyi Yang,&nbsp;Jiwei Jiang,&nbsp;Linlin Wang,&nbsp;Min Zhao,&nbsp;Wenyi Li,&nbsp;Yunyun Duan,&nbsp;Qiwei Ren,&nbsp;Tianlin Jiang,&nbsp;Shirui Jiang,&nbsp;Huiying Zhang,&nbsp;Yilong Wang,&nbsp;Weiqi Chen,&nbsp;Jun Xu","doi":"10.1007/s40520-025-03045-0","DOIUrl":"10.1007/s40520-025-03045-0","url":null,"abstract":"<div><h3>Background</h3><p>Gait disturbance is a prevalent characteristic of cerebral small vessel disease (CSVD), yet the underlying mechanisms remain largely unclear.</p><h3>Aimes</h3><p>To test the hypothesis that enlarged perivascular spaces in the basal ganglia (BG-EPVS) are related to gait performance in individuals with CSVD and the elderly.</p><h3>Methods</h3><p>This cross-sectional study included 138 CSVD patients and 62 healthy elderly controls who underwent quantitative gait analysis. Neuroimaging markers, including BG-EPVS, white matter hyperintensities (WMH), lacunes, and cerebral microbleeds (CMB), were assessed using MRI. Principal component analysis (PCA) was used to reduce the dimensionality of multiple gait indicators. Linear regression models were employed to examine the relationship between BG-EPVS and the principal component values of gait performance, with WMH as a potential mediator.</p><h3>Results</h3><p>Compared to healthy controls, CSVD patients exhibited significantly prolonged stance and double-support phases, shortened swing phase, reduced gait speed, increased step width, and decreased stride length and step height (<i>p</i> &lt; 0.05 for all comparisons). Higher BG-EPVS grades were independently associated with poorer gait performance in both CSVD patients (<i>p</i> = 0.012) and all subjects (<i>p</i> = 0.001), even after adjusting for other CSVD markers. WMH partially mediated the relationship between BG-EPVS and gait performance, accounting for 18.2% of the total effect in CSVD patients and 24.9% of the total effects in all subjects.</p><h3>Conclusion</h3><p>BG-EPVS is independently associated with gait disturbances in both CSVD patients and the elderly. These findings underscore the importance of early gait assessment in the aging population. Further longitudinal research is needed to confirm these associations.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03045-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal association between chronic pain and frailty occurrence, and the modifiable role of a healthy lifestyle in Chinese middle-aged and older population: a community based, prospective cohort study","authors":"Chao Li,&nbsp;Na Zeng,&nbsp;Fu-Shan Xue","doi":"10.1007/s40520-025-03042-3","DOIUrl":"10.1007/s40520-025-03042-3","url":null,"abstract":"<div><h3>Background</h3><p>While western studies suggest a temporal association between chronic pain and frailty, as well as the impacts of healthy lifestyle interventions, these relationships remain underexplored in the Chinese population.</p><h3>Methods</h3><p>We conducted a longitudinal study with 13,601 participants from the China Health and Retirement Longitudinal Study, covering 2011–2018. Pain was assessed via self-report, and frailty was evaluated using a 29-item deficit-accumulation frailty index. Five lifestyle factors, such as physical activity, alcohol consumption, smoking, body mass index, and sleep duration, were assessed, and the participants were categorized into favorable, intermediate, and unfavorable lifestyle groups.</p><h3>Results</h3><p>During the 7-year follow-up, 3,356 cases of frailty were discerned. Participants who reported pain at baseline assessment had a higher risk of developing frailty compared to those without pain (hazard ratio [HR] = 1.10; 95%confidence interval [CI], 1.03–1.19). This association was particularly evident in middle-aged individuals (HR = 1.13; 95% CI, 1.01–1.26). <i>P</i>articipants with severe pain at baseline assessment had a 1.16-fold higher risk of frailty (95%CI, 1.05–1.28, <i>P</i>_trend= 0.0067). Among the participants with mild or moderate pain at baseline assessment, the risk of developing frailty was significantly reduced by a favorable lifestyle (HR = 0.62; 95% CI, 0.51–0.76) or intermediate lifestyle (HR = 0.83; 95% CI, 0.70–0.98). Additionally, a favorable lifestyle was significantly associated with a decreased risk of developing frailty in the participants with severe pain at baseline assessment (HR = 0.75; 95%CI, 0.59–0.96). Mediation analysis indicated that a healthy lifestyle could mitigate 2.97% of frailty risk associated with chronic pain.</p><h3>Conclusions</h3><p>Chronic pain is strongly associated with an increased risk of developing frailty in Chinese older population, but the implementation of healthy lifestyles can significantly reduce this risk.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03042-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effect between telomere length and thirteen types of cancer in Asian population: a bidirectional Mendelian randomization study","authors":"Bowen Yang,&nbsp;Junming Bi,&nbsp;Weinan Zeng,&nbsp;Mingquan Chen,&nbsp;Zhihao Yao,&nbsp;Shouyu Cheng,&nbsp;Zhaoqiang Jiang,&nbsp;Changzheng Zhang,&nbsp;Hangyu Liao,&nbsp;Xiaokang Gu,&nbsp;Zhiyong Xian,&nbsp;Yuming Yu","doi":"10.1007/s40520-025-03046-z","DOIUrl":"10.1007/s40520-025-03046-z","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between leukocyte telomere length (LTL) and the risk of developing various cancers has always been controversial and predominantly focused on European populations. Hence, Mendelian randomization (MR) was applied to the Asian population to explore the causal relationships between LTL and the risk of developing various cancers.</p><h3>Methods</h3><p>We explored the causal connection between LTL and the risk of developing thirteen types of cancer in Asian populations using freely available genetic variation data. The primary analytical method employed was the inverse variance weighted (IVW) method, complemented by sensitivity and validation analyses. Following Bonferroni correction, <i>P</i> &lt; 0.0038 was considered to indicate statistical significance, and P values ranging from 0.0038 to 0.05 were considered to indicate a nominally significant association.</p><h3>Results</h3><p>The findings indicated significant positive associations between LTL and the risk of developing lung cancer [odds ratio (OR) = 1.6009, 95% confidence interval (CI) 1.3056–1.9629, <i>P</i> = 6.08 × 10⁻⁶] and prostate cancer (OR = 1.4200, 95% CI 1.1489–1.7550, <i>P</i> = 0.0012). Additionally, there was a nominally significant association between LTL and the risk of developing hematological malignancy (OR = 1.5119, 95% CI 1.0810–2.1146, <i>P</i> = 0.0157). No statistically significant relationships between LTL and the risk of developing the other ten kinds of cancer were detected. No causal link between the risk of developing various cancers and LTL was discovered.</p><h3>Conclusions</h3><p>Asians with longer telomeres are more prone to developing lung and prostate cancer. There is also a nominally significant association between longer telomeres and the risk of developing hematological malignancy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03046-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}