Aging Clinical and Experimental Research最新文献

{"title":"Health outcomes of sarcopenia: a consensus report by the outcome working group of the Global Leadership Initiative in Sarcopenia (GLIS)","authors":"Charlotte Beaudart,&nbsp;Julian Alcazar,&nbsp;Ivan Aprahamian,&nbsp;John A. Batsis,&nbsp;Yosuke Yamada,&nbsp;Carla M. Prado,&nbsp;Jean-Yves Reginster,&nbsp;Dolores Sanchez-Rodriguez,&nbsp;Wee Shiong Lim,&nbsp;Marc Sim,&nbsp;Stephan von Haehling,&nbsp;Jean Woo,&nbsp;Gustavo Duque,&nbsp;The Global Leadership Initiative in Sarcopenia (GLIS) group","doi":"10.1007/s40520-025-02995-9","DOIUrl":"10.1007/s40520-025-02995-9","url":null,"abstract":"<div><p>The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the GLIS has organized three different working groups (WGs), with the WG on outcomes of sarcopenia focusing on reporting its health outcomes to be measured in clinical practice once a diagnosis has been established. This includes sarcopenia definitions that better predict health outcomes, the preferred tools for measuring these outcomes, and the cutoffs defining normal and abnormal values. The present article synthesizes discussions and conclusions from this WG, composed of 13 key opinion leaders from different continents worldwide. Results rely on systematic reviews, meta-analyses, and relevant cohort studies in the field. With a high level of evidence, sarcopenia is significantly associated with a reduced quality of life, a higher risk of falls and fractures and a higher risk of mortality. Sarcopenia has been moderately associated with a higher risk of reduced instrumental activities of daily living (IADL). However, the GLIS WG found only inconclusive level of evidence to support associations between sarcopenia and higher risks of hospitalization, nursing home admission, mobility impairments, and reduced basic activities of daily living (ADL). This limitation underscores the scarcity of longitudinal studies, highlighting a barrier to understanding its progression and implications over time.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02995-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting countries to ensure the continuum of integrated care for older people","authors":"Yuka Sumi,&nbsp;Rachel Albone,&nbsp;Matteo Cesari","doi":"10.1007/s40520-025-02970-4","DOIUrl":"10.1007/s40520-025-02970-4","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02970-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts","authors":"Nazario Carrabba,&nbsp;Mattia Alexis Amico,&nbsp;Gherardo Busi,&nbsp;Matteo Vannini,&nbsp;Filippo Bruscoli,&nbsp;Salvatore Fortunato,&nbsp;Luciano Arcari,&nbsp;Emilio Di Lorenzo,&nbsp;Giampaolo Luzi,&nbsp;Francesco Clemenza,&nbsp;Francesco Amico,&nbsp;Giuseppe Pes,&nbsp;Marco Merlo,&nbsp;Gianfranco Sinagra,&nbsp;Giovambattista Desideri,&nbsp;Francesco Vetta,&nbsp;Alessandro Mugelli,&nbsp;Niccolo Marchionni,&nbsp;Alessandro Boccanelli,&nbsp;the PREVASC Working Group, Italian Society of Geriatrica Cardiology (SICGe)","doi":"10.1007/s40520-025-02937-5","DOIUrl":"10.1007/s40520-025-02937-5","url":null,"abstract":"<div><h3>Aims</h3><p>Valvular heart disease (VHD) is the third leading cause of cardiovascular morbidity, with its incidence and public health impact projected to increase significantly. This study adopts a novel perspective, focusing on elderly individuals residing in rural areas, highlighting the unique dynamics of small-town settings.</p><h3>Methods</h3><p>This multicenter, observational study was conducted from May 2022 to September 2023, under the coordination of the AOU Careggi Echo Core-Lab, which managed the entire screening program. In 10 small Italian villages, each municipality facilitated the enrollment of asymptomatic individuals aged ≥ 65 years, with no prior VHD history, through voluntary participation. Participants were grouped into three age categories (65–69, 70–74, and ≥ 75 years) and underwent a thorough evaluation, including a Quality of Life (QoL) questionnaire and comprehensive echocardiographic assessment focusing on VHD detection and grading.</p><h3>Results</h3><p>Among 1,113 participants, the prevalence and severity of VHD showed a significant increase with age (<i>p</i> &lt; 0.0001). Remarkably, 94% of individuals aged ≥ 75 years had at least one valvular defect, with 22.5% presenting moderate or severe valvulopathy, including a prevalence of 4.8% for moderate or severe aortic valve stenosis and 7.5% for mitral regurgitation. Right-sided valvulopathies followed a similar trend, affecting 71.9% of elderly participants. QoL evaluations revealed a generally positive perceived health status, with a mean score of 77 ± 16.</p><h3>Conclusions</h3><p>Our registry highlights that the prevalence of VHD in asymptomatic individuals over 65 years living in small Italian communities is substantial, increases with age, and is predominantly degenerative in etiology. Notably, most individuals with undiagnosed VHD perceived themselves as healthy.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02937-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and waist circumference as key determinants of postoperative thrombosis and squatting recovery after unicompartmental knee arthroplasty","authors":"Xuyang Cao,&nbsp;Mengsha Wang,&nbsp;Zizi Zhao,&nbsp;Taotao Kong","doi":"10.1007/s40520-025-02974-0","DOIUrl":"10.1007/s40520-025-02974-0","url":null,"abstract":"<div><h3>Background</h3><p>Thrombosis is a common postoperative complication after unicompartmental knee arthroplasty (UKA), and the ability to squat is an important functional outcome reflecting recovery of knee function. This study aimed to investigate the factors influencing postoperative thrombosis as well as the ability to squat within 1 year after UKA.</p><h3>Methods</h3><p>Data from UKA patients were retrospectively analyzed and grouped based on the occurrence of thrombosis (including deep vein thrombosis and superficial vein thrombosis) and the ability to squat within 1 year. Factors affecting thrombosis and squatting were compared and analyzed using multifactorial logistic regression.</p><h3>Results</h3><p>Univariate analysis revealed that age (<i>P</i> = 0.014), pre-operative haemoglobin (<i>P</i> = 0.044), and gender (<i>P</i> = 0.047) were associated with thrombosis, while multifactorial analysis found age (<i>P</i> = 0.024) as the key factor. Regarding squatting ability, univariate analysis identified age (<i>P</i> = 0.018), body weight (<i>P</i> = 0.001), BMI (<i>P</i> = 0.001), waist circumference (<i>P</i> &lt; 0.001), pre-operative VAS score (<i>P</i> = 0.002), and family living conditions (<i>P</i> = 0.019) as influencing factors, with multifactorial analysis identifying waist circumference (<i>P</i> = 0.002) as a significant factor.</p><h3>Conclusions</h3><p>Older age increases the likelihood of thrombosis after UKA. Additionally, a larger waist circumference decreases the likelihood of squatting within 1 year after surgery.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02974-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults produce more verbal false memories than younger adults: is it semantics or executive functioning?","authors":"Martina Cangelosi,&nbsp;Luca Rinaldi,&nbsp;Ton Dijkstra,&nbsp;Paola Palladino,&nbsp;Elena Cavallini","doi":"10.1007/s40520-024-02914-4","DOIUrl":"10.1007/s40520-024-02914-4","url":null,"abstract":"<div><h3>Background</h3><p>A verbal false memory occurs when one remembers a word (called “critical lure”) as part of a previously presented list despite its absence. This phenomenon may be linked to the semantic associations of the critical lure with actual list items.</p><h3>Aims</h3><p>We aimed to investigate the mechanisms behind the increase in verbal false memories with aging, evaluating whether this is due to a greater reliance on semantic processing or impaired executive functioning.</p><h3>Methods</h3><p>We employed the Deese-Roediger-McDermott (DRM) paradigm, presenting DRM word lists to two age groups: young adults and older adults. In addition, participants completed the Hayling Sentence Completion Test to assess inhibition and the Backward Digit Span Task to evaluate working memory.</p><h3>Results</h3><p>Our findings confirm that older adults experience more verbal false memories than younger participants. Results suggest that both semantic processing reliance and inhibition impairment contribute to the increase in false memories with aging, while working memory was not significantly related to false memory production.</p><h3>Discussion</h3><p>Older adults’ increased susceptibility to false memories appears to arise from an interplay between enhanced semantic reliance and inhibition deficits.</p><h3>Conclusions</h3><p>This study proposes a novel integration of semantic and executive mechanisms underlying the observed increase in false memories during aging, with inhibition playing an unexpected role in enhancing false memory susceptibility.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02914-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the coexistence of chronic kidney disease and sarcopenia with cardiovascular disease and mortality","authors":"Lijun Jiang,&nbsp;Liangliang Xu,&nbsp;Wen Sun,&nbsp;Keyu Bian,&nbsp;Yuan Wang","doi":"10.1007/s40520-025-03003-w","DOIUrl":"10.1007/s40520-025-03003-w","url":null,"abstract":"<div><h3>Background</h3><p>Chronic kidney disease (CKD) and sarcopenia are independently associated with adverse cardiovascular and mortality outcomes. However, the combined impact of CKD and sarcopenia remains poorly understood. To evaluate the combined effects of CKD and sarcopenia on cardiovascular disease (CVD) and mortality risks in a large population-based cohort.</p><h3>Methods</h3><p>We analyzed data from 477,380 participants in the UK Biobank, categorized into four groups based on the presence or absence of CKD and sarcopenia: Non-CKD Non-Sarcopenia, Non-CKD Sarcopenia, CKD Non-Sarcopenia, and CKD Sarcopenia. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD and mortality outcomes. Kaplan-Meier survival analyses compared event-free survival across the groups.</p><h3>Results</h3><p>Participants with both CKD and sarcopenia exhibited the highest risks across all outcomes compared to those without either condition. For stroke, the adjusted HR was 2.17 (95% CI: 1.65–2.86), significantly higher than CKD alone (HR: 1.69, 95% CI: 1.47–1.94) or sarcopenia alone (HR: 1.28, 95% CI: 1.03–1.59). Similar trends were observed for coronary artery disease (CAD) and heart failure (HF), with HRs of 1.53 (95% CI: 1.38–1.69) and 2.22 (95% CI: 1.99–2.47), respectively, in the CKD-sarcopenia group. The coexistence of CKD and sarcopenia was also associated with significantly elevated all-cause mortality (HR: 2.59, 95% CI: 2.17–3.09) and cardiovascular-specific mortality (HR: 4.08, 95% CI: 2.95–5.66).</p><h3>Conclusion</h3><p>The coexistence of CKD and sarcopenia significantly amplifies the risks of CVD and mortality, highlighting the need for integrated management strategies to address this high-risk population. Early detection and tailored interventions targeting these dual risk factors may mitigate their compounded burden and improve clinical outcomes.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03003-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Skill-Based multimodal intervention for dementia caregivers: impact on burden and anxiety","authors":"Doaa Said Amin Abdelhalim,&nbsp;Marwa Mostafa Ahmed,&nbsp;Hoda Abdou Hussein,&nbsp;Mai Diaa Sarhan,&nbsp;Ola Osama Khalaf","doi":"10.1007/s40520-025-02985-x","DOIUrl":"10.1007/s40520-025-02985-x","url":null,"abstract":"<div><h3>Background</h3><p>Dementia is a global health challenge affecting both patients and their caregivers, with family members often bearing the primary caregiving burden. In Egypt, where research on caregiver mental health is limited, interventions addressing caregiver burden and anxiety is critical.</p><h3>Aim</h3><p>To determine the effect of a psychoeducation and skill-based multimodal intervention on caregiver burden and anxiety.</p><h3>Methods</h3><p>A randomized controlled trial (RCT) involving 84 family caregivers. Participants were assigned to either the intervention group (<i>n</i> = 42), which received structured psychoeducation and skill-based training over six biweekly sessions, or the control group (<i>n</i> = 42), which received routine outpatient care. Caregiver burden and anxiety were assessed using the Zarit Burden Interview (ZBI) and the Generalized Anxiety Disorder Scale (GAD-7). Behavioral and psychological symptoms of dementia were evaluated using the Neuropsychiatric Inventory Questionnaire (NPI-Q).</p><h3>Results</h3><p>The sample consisted predominantly of women (79% in the intervention group, 69% in the control group), with daughters forming the largest caregiver subgroup (66.6% and 52.4%, respectively). The mean age of caregivers was 39.2 ± 4.2 years. After three months, caregivers in the intervention group exhibited a significant reduction in burden (ZBI median score: 24 vs. 34, <i>p</i> &lt; 0.0001) and anxiety (GAD-7 mean score: 6.15 vs. 9.4, <i>p</i> &lt; 0.0001) compared to the control group, however, NPI-Q scores remained unchanged.</p><h3>Conclusion</h3><p>A structured psychoeducation and skill-based intervention significantly reduces caregiver burden and anxiety. Implementing such programs in Egypt could improve the well-being of caregivers and individuals with dementia.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02985-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of alternative healthy eating index with risk of frailty among metabolic syndrome individuals: a cross-sectional study","authors":"Yi Wei,&nbsp;Min Zha,&nbsp;Jiangyi Yu","doi":"10.1007/s40520-025-02992-y","DOIUrl":"10.1007/s40520-025-02992-y","url":null,"abstract":"<div><h3>Background</h3><p>Mounting evidence identifies diet quality as a frailty modifying factor. Individuals suffering from metabolic syndrome (MetS) are more likely to be affected by frailty. Therefore, our research sought to explore the relationship of Alternative Healthy Eating Index (AHEI) with frailty risk among patients with MetS.</p><h3>Methods</h3><p>National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018 were gathered. Frailty Index (FI) was utilized for assessment of frailty status. Weighted multivariate logistic regression model was adopted for investigating the association of AHEI with frailty among patients with MetS. Subgroup analysis, interaction test and restricted cubic spline (RCS) test were also performed in this study.</p><h3>Results</h3><p>When the covariates considered were entirely adjusted for, higher AHEI scores exhibited significant association with reduced frailty risk (OR = 0.99,95%CI = 0.981–0.998, <i>P</i> = 0.022). Relative to the frailty risk among participants belonging to the lowest AHEI quartile(Q1), that of individuals in the highest AHEI quartile(Q4) decreased by 32% (OR = 0.68, 95% CI = 0.51–0.92, <i>P</i> = 0.01). Additionally, the negative association of AHEI with frailty persisted for all subgroup analyses, which also indicates the reliability of the relationship.</p><h3>Conclusion</h3><p>For patients with MetS, higher AHEI scores reduce the risk of developing frailty. This investigation provides valuable knowledge that could be utilized for treating MetS patients clinically and guiding healthy eating program development.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02992-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function in generally healthy adults age 70 years and older in the 5-country DO-HEALTH study: MMSE and MoCA scores by sex, education and country","authors":"Melanie Kistler-Fischbacher,&nbsp;Ghazala Gohar,&nbsp;Caroline de Godoi Rezende Costa Molino,&nbsp;Katharina Geiling,&nbsp;Tatjana Meyer-Heim,&nbsp;Reto W. Kressig,&nbsp;E. John Orav,&nbsp;Bruno Vellas,&nbsp;Sophie Guyonnet,&nbsp;José A.P. da Sliva,&nbsp;René Rizzoli,&nbsp;Gabriele Armbrecht,&nbsp;Elisabeth Steinhagen-Thiessen,&nbsp;Andreas Egli,&nbsp;Heike A. Bischoff-Ferrari","doi":"10.1007/s40520-025-02946-4","DOIUrl":"10.1007/s40520-025-02946-4","url":null,"abstract":"<div><h3>Background</h3><p>Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are validated and frequently used screening tools for cognitive function.</p><h3>Aims</h3><p>To present MMSE and MoCA scores by sex, age and education among community-dwelling older adults.</p><h3>Methods</h3><p>This is a post-hoc observational analysis using data from the DO-HEALTH trial, which included generally healthy adults (≥ 70 years) from Switzerland, Germany, Austria, France, and Portugal who scored at least 24 points on the MMSE at baseline. We present MMSE and MoCA scores overall and by country, sex, age (70–74 years, ≥ 75 years), education (≤ and &gt; median education years).</p><h3>Results</h3><p>2151 DO-HEALTH participants (mean age 74.9 years, 57% aged 70–74 years, 62% women) were included. The median (IQR) years of education was 12 (10–15), median MMSE score was 29 (28–30) and median MoCA score was 26 (23–28) points. In subgroups by sex, age, and education, the median MMSE score remained 29 for all subgroups, except for participants with shorter education (≤ 12 years) and higher age (≥ 75), who scored 28 points. For MoCA, the median score in subgroups ranged from 24 to 27 points. Participants with shorter education (≤ 12 years) and higher age (≥ 75) had lowest scores (men 24, women 25 points).</p><h3>Conclusions</h3><p>We provide MMSE and MoCA scores for generally healthy, community-dwelling older adults from Switzerland, Germany, Austria, France and Portugal. The median MMSE and MoCA scores differed with age and education, and – less consistently – with sex.</p><h3>Trial registration</h3><p>International Trials Registry (clinicaltrials.gov; registration ID: NCT01745263), registered December 2012.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02946-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fruit and vegetable consumption and injurious falls among adults aged ≥ 50 years from low- and middle-income countries","authors":"Lee Smith,&nbsp;Guillermo F. López Sánchez,&nbsp;Nicola Veronese,&nbsp;Mark A Tully,&nbsp;Damiano Pizzol,&nbsp;Laurie Butler,&nbsp;Masoud Rahmati,&nbsp;José Francisco López-Gil,&nbsp;Yvonne Barnett,&nbsp;Louis Jacob,&nbsp;Pinar Soysal,&nbsp;Alberto Castagna,&nbsp;Jae Il Shin,&nbsp;Ai Koyanagi","doi":"10.1007/s40520-025-02966-0","DOIUrl":"10.1007/s40520-025-02966-0","url":null,"abstract":"<div><h3>Objective</h3><p>Inadequate fruit and vegetable consumption may increase risk for falls. However, to date, only one study has examined this association in a sample restricted to females, while the mediators of this association are largely unknown. Therefore, we aimed to examine the association between fruit and vegetable consumption and injurious falls, and to identify potential mediators in a sample including both males and females.</p><h3>Methods</h3><p>Cross-sectional, nationally representative data from the World Health Organization (WHO) Study on global AGEing and adult health (SAGE) were analyzed. Fruit/vegetable consumption was divided into two groups: ≥2 servings of fruits and ≥3 servings of vegetables per day (adequate consumption) or else (inadequate consumption). Fall-related injury referred to those that occurred in the past 12 months. Multivariable logistic regression and mediation analysis were conducted.</p><h3>Results</h3><p>Data on 34,129 individuals aged ≥ 50 years were analyzed (mean age 62.4 years; 52.1% females). Overall, inadequate fruit/vegetable intake was associated with a significant 1.41 (95%CI = 1.05–1.90) times higher odds for injurious falls. This association was only significant among females (OR = 1.96; 95%CI = 1.32–2.85). Mediation analysis showed that affect (mediated percentage 8.8%), cognition (7.2%), and sleep/energy (7.5%) were significant mediators, but vision, grip strength, and gait speed were not.</p><h3>Conclusions</h3><p>Inadequate fruit and vegetable consumption was associated with higher odds for injurious falls among adults aged ≥ 50 years (especially females), and this association was partly mediated by cognition, affect, and sleep/energy. Future longitudinal studies are necessary to provide more insight into the underlying mechanisms, and to assess whether increasing fruit/vegetable consumption may reduce risk for falls.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-02966-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}