Aging Clinical and Experimental Research最新文献

{"title":"Association between the incident hypertension duration and cognitive performance in older adults: data from the NHANES 2011–2014","authors":"Chunlei Liu,&nbsp;Qi Li,&nbsp;Zhuqing Li,&nbsp;Li Wang,&nbsp;Che Wang,&nbsp;Xiaoyu Du,&nbsp;Wenjuan Song,&nbsp;Xiaotong Sun,&nbsp;Chengzhi Lu","doi":"10.1007/s40520-024-02836-1","DOIUrl":"10.1007/s40520-024-02836-1","url":null,"abstract":"<div><h3>Background</h3><p>Established evidences have demonstrated that hypertension was associated with the cognitive impairment. But the associations between the duration of hypertension exposure and cognitive performance are still inconclusive.</p><h3>Objectives</h3><p>The objective of this study was to assess the association between the duration of hypertension diagnosis and cognitive performance in older adults by the National Health and Nutrition Examination Survey (2011–2014).</p><h3>Methods</h3><p>To evaluate the relationship between the hypertension duration and cognitive performance, we conducted the logistic regression analysis. Furthermore, we also performed the Restricted cubic spline (RCS) analysis to assess the nonlinear relationship between the duration of exposure to hypertension and cognitive performance.</p><h3>Results</h3><p>Initially, total 19,931 participants were included in this study, and 2928 individuals were enrolled. With the increase of hypertension duration, more risk of cognitive impairment was observed in the Digit Symbol Substitution test (DSST) (OR = 1.012, 1.006–1.019), and a similar trend was observed in Animal Fluency test (AFT) (OR = 1.009,1.003–1.016). The RCS results showed that the hypertension duration pattern was linear associated with the risk of cognitive impairment in DDST (P for non–linearity = 0.758). Meanwhile, subgroups analysis of midlife hypertension, we revealed that linear association with the risk of cognitive impairment in DSST (P for non–linearity = 0.391) and CERAD (P for non–linearity = 0.849) among hypertension diagnose &lt; 55 years populations.</p><h3>Conclusion</h3><p>Collectively, our finding indicates that longer duration of exposure to hypertension worsens the cognition performance, especially for middle-aged hypertension.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons influencing the nurses’ prioritization process while preventing and managing delirium: findings from a qualitative study","authors":"Luisa Sist,&nbsp;Nikita Valentina Ugenti,&nbsp;Stefania Chiappinotto,&nbsp;Rossella Messina,&nbsp;Paola Rucci,&nbsp;Alvisa Palese","doi":"10.1007/s40520-024-02818-3","DOIUrl":"10.1007/s40520-024-02818-3","url":null,"abstract":"<div><h3>Background</h3><p>Nurses play an important role in the prevention and management of delirium episodes. However, some studies have reported that not all interventions recommended are applied due to time and resource constraints, resulting in patients receiving less care than required because other patients and/or interventions are prioritised. The concept of prioritization is part of the broader concept of decision-making as the ability to choose between two or more alternatives to ensure patient safety. Understanding the reasons influencing the prioritization process in patients at risk or with delirium may inform interventions to prevent and/or minimise the unfinished nursing care.</p><h3>Aim</h3><p>The purpose of this study was to explore the reasons that inform the prioritisation process among nurses when they are challenged to make decisions for patients at risk and with delirium.</p><h3>Methods</h3><p>A descriptive qualitative study performed according to the COnsolidated criteria for Reporting guidelines, in 2021. An intentional sample of nurses working full-time with older patients in medical, geriatric, and post-acute care facilities affiliated with the National Health System was involved. Semi-structured interviews were conducted and narratives thematic analysed.</p><h3>Results</h3><p>A total of 56 nurses (55.4% in internal medicine, 26.8% in geriatrics and 17.8% in post-acute/intermediate care) participated with an average age of 31.6 years. The reasons informing the prioritisation process while providing preventive or managerial interventions towards a patient at risk of or with delirium are set at three levels: (1) unit level, as reasons belong to the inadequacy of the ‘Environment’, the ‘Human Resources’, and the ‘Organisation and Work Processes’, (2) nurse’s level, as issues in ‘Competencies’ and ‘Attitudes’ possessed, and (3) patient level, due to the ‘Multidimensional Frailty’.</p><h3>Conclusion</h3><p>Nurses caring for patients at risk of and with delirium face several challenges in providing care. To prioritise preventive and managerial interventions, it is essential to implement multilevel and multifaced organizational and educational strategies.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal factors for osteoarthritis risk revealed by mendelian randomization analysis","authors":"Qingfeng Luo,&nbsp;Shiyong Zhang,&nbsp;Qiyuan Yang,&nbsp;Yuyi Deng,&nbsp;Hengjing Yi,&nbsp;Xingsheng Li","doi":"10.1007/s40520-024-02812-9","DOIUrl":"10.1007/s40520-024-02812-9","url":null,"abstract":"<div><p>Osteoarthritis (OA), a prevalent chronic disease among the elderly, presents a complex pathogenesis and currently lacks effective treatment. Traditional observational studies are time-consuming, labor-intensive, susceptible to confounding factors, and cannot establish causal relationships. Mendelian randomization (MR) analysis, leveraging genetic variation to assess causal associations between exposures and outcomes, offers a cost-effective and efficient alternative. Over the past decade, large-scale genome-wide association studies have identified numerous genetic variants linked to OA risk factors, facilitating MR study design. In this review, we systematically identified 52 MR studies meeting specific criteria and evaluated their quality, exploring the impact of lifestyle, nutrition, comorbidities, circulating metabolites, plasma proteins, and other health factors on OA risk. We discuss the results and potential mechanisms of MR findings, addressing conflicting evidence based on existing literature and our prior research. With the ongoing expansion of genome-wide association data, we anticipate MR’s role in future OA studies to broaden, particularly in drug development research using targeted MR approaches. We thus aim for this paper to offer valuable insights for researchers and clinicians in related fields.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of detraining on neuromuscular function and structural adaptations following once- or twice-weekly eccentric resistance training in older adults","authors":"Brett A. Baxter,&nbsp;Anthony W. Baross,&nbsp;Declan J. Ryan,&nbsp;Anthony D. Kay","doi":"10.1007/s40520-024-02828-1","DOIUrl":"10.1007/s40520-024-02828-1","url":null,"abstract":"<div><h3>Background</h3><p>Eccentric resistance training elicits greater preservation of training-induced muscular adaptations compared with other training modalities, however the detraining profiles of different training dosages remain unknown.</p><h3>Aims</h3><p>To examine the detraining effects following once- or twice-weekly eccentric-specific resistance training in older adults.</p><h3>Methods</h3><p>Twenty-one older adults (age = 70.5 ± 6.0 year) completed a 12-week detraining period following the 12-week eccentric training programmes with neuromuscular function and muscle structure assessed six (mid-detraining) and 12 (post-detraining) weeks following training cessation.</p><h3>Results</h3><p>From post-training to post-detraining, no significant regression of the training-induced improvements (collapsed group data reported) occurred in power (0%), strength (eccentric = 0%, isometric = 39%), or explosive strength over numerous epochs (0–32%), resulting in values that remained significantly greater than at pre-training. However, significant regression in the improvements in muscle thickness (91%) and fascicle angle (100%) occurred, resulting in values that were not significantly greater than pre-training.</p><h3>Discussion</h3><p>The limited regression in neuromuscular function following a 12-week detraining period has important implications for supporting eccentric exercise prescription in older adults who often face periods of inactivity. However, further work is required to develop an effective maintenance dosage strategy that preserves improvements in muscle structure.</p><h3>Conclusions</h3><p>Eccentric resistance training elicits improvements in the neuromuscular function of older adults, which are sustained for at least 12 weeks after eccentric training cessation.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress hyperglycemia ratio and its influence on mortality in elderly patients with severe community-acquired pneumonia: a retrospective study","authors":"Lei Miao,&nbsp;Xiaozhu Shen,&nbsp;Zhiqiang Du,&nbsp;Jingxian Liao","doi":"10.1007/s40520-024-02831-6","DOIUrl":"10.1007/s40520-024-02831-6","url":null,"abstract":"<div><h3>Background</h3><p>Community-acquired pneumonia (CAP) is a significant health issue among the elderly, with severe cases (SCAP) having high mortality rates. This study assesses the predictive significance of the stress hyperglycemia ratio (SHR) in elderly SCAP patients and its impact on outcomes in both diabetic and non-diabetic patients.</p><h3>Methods and materials</h3><p>This retrospective study included 406 SCAP patients aged 65 or older from the Second People’s Hospital of Lianyungang (January 2020 to December 2023). Data collected included demographics, medical history, vital signs, and lab results. SHR was calculated from initial blood glucose and estimated average glucose (HbA1c). Statistical analyses, including Cox regression and Kaplan-Meier analysis, evaluated SHR’s impact on mortality. Mediation models explored the effects of neutrophil-lymphocyte ratio (NLR) and SHR.</p><h3>Results</h3><p>The 28-day mortality rate was 21.67%. Deceased patients had higher age, Charlson Comorbidity Index, procalcitonin, NLR, glucose, and SHR levels compared to survivors (<i>P</i> &lt; 0.05). Both SHR and NLR significantly increased mortality risk, particularly in non-diabetic patients. Combining NLR and SHR improved ROC AUC to 0.898, with 89.80% sensitivity and 81.10% specificity. Kaplan-Meier analysis showed higher cumulative survival for SHR &lt; 1.14, regardless of diabetes status (<i>P</i> &lt; 0.05). NLR mediated 13.02% of the SHR-survival relationship, while SHR mediated 14.06% of the NLR-survival relationship.</p><h3>Conclusion</h3><p>Elevated SHR is a significant mortality risk factor in elderly SCAP patients, independent of diabetes status. Stringent glucose control and careful monitoring of SHR may improve outcomes in elderly patients with acute respiratory conditions.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis","authors":"Xiaoran Wang,&nbsp;Wenjing Chen,&nbsp;Wenxia Zhao,&nbsp;Mingsan Miao","doi":"10.1007/s40520-024-02811-w","DOIUrl":"10.1007/s40520-024-02811-w","url":null,"abstract":"<div><h3>Background</h3><p>Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated.</p><h3>Objective</h3><p>This study was aimed to assess whether glaucoma increase the risk of dementia or cognitive impairment.</p><h3>Methods</h3><p>PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort or case-control studies were searched from inception to March 10, 2024. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to the risk of bias. Heterogeneity was rigorously evaluated using the <i>I</i>² test, while publication bias was assessed by visual inspection of the funnel plot and by Egger’ s regression asymmetry test. Subgroup analyses were applied to determine the sources of heterogeneity.</p><h3>Results</h3><p>Twenty-seven studies covering 9,061,675 individuals were included. Pooled analyses indicated that glaucoma increased the risk of all-cause dementia, Alzheimer’s disease, vascular dementia, and cognitive impairment. Subgroup analysis showed that the prevalence of dementia was 2.90 (95% CI: 1.45–5.77) in age ≥ 65 years and 2.07 (95% CI: 1.18–3.62) in age&lt;65 years; the incidence rates in female glaucoma patients was 1.46 (95% CI: 1.06-2.00), respectively, which was no statistical significance in male patients. Among glaucoma types, POAG was more likely to develop dementia and cognitive impairment. There were also differences in regional distribution, with the highest prevalence in the Asia region, while glaucoma was not associated with dementia in Europe and North America regions.</p><h3>Conclusion</h3><p>Glaucoma increased the risk of subsequent cognitive impairment and dementia. The type of glaucoma, gender, age, and region composition of the study population may significantly affect the relationship between glaucoma and dementia.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies","authors":"Justyna Godos,&nbsp;Agnieszka Micek,&nbsp;Walter Currenti,&nbsp;Carlotta Franchi,&nbsp;Andrea Poli,&nbsp;Maurizio Battino,&nbsp;Alberto Dolci,&nbsp;Cristian Ricci,&nbsp;Zoltan Ungvari,&nbsp;Giuseppe Grosso","doi":"10.1007/s40520-024-02823-6","DOIUrl":"10.1007/s40520-024-02823-6","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.</p><h3>Aims</h3><p>To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.</p><h3>Methods</h3><p>A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs).</p><h3>Results</h3><p>The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95% CI: 0.75, 0.90, <i>I</i>^<i>2</i> = 61.1%), dementia (RR = 0.82, 95% CI: 0.73, 0.93, <i>I</i>^<i>2</i> = 38.7%), and Alzheimer’s disease (RR = 0.80, 95% CI: 0.67, 0.96, <i>I</i>^<i>2</i> = 20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR = 0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ε4 allele status was mixed based on the outcome investigated.</p><h3>Conclusions</h3><p>Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer’s disease there is a need for further studies to improve the strength of evidence.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2024)","authors":"","doi":"10.1007/s40520-024-02766-y","DOIUrl":"10.1007/s40520-024-02766-y","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1 supplement","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World congress on osteoporosis, osteoarthritis and musculoskeletal diseases 2024","authors":"","doi":"10.1007/s40520-024-02774-y","DOIUrl":"10.1007/s40520-024-02774-y","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1 supplement","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-024-02774-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis","authors":"Weichu Sun,&nbsp;Hui Xiao,&nbsp;Yayun Li","doi":"10.1007/s40520-024-02813-8","DOIUrl":"10.1007/s40520-024-02813-8","url":null,"abstract":"<div><h3>Background</h3><p>Previous observational studies indicated a complex association between frailty and arthritis.</p><h3>Aims</h3><p>To investigate the genetic causal relationship between the frailty index and the risk of common arthritis.</p><h3>Methods</h3><p>We performed a large-scale Mendelian randomization (MR) analysis to assess frailty index associations with the risk of common arthritis in the UK Biobank (UKB), and the FinnGen Biobank. Summary genome-wide association statistics for frailty, as defined by the frailty index, and common arthritis including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PSA), and ankylosing spondylitis (AS). The inverse-variance weight (IVW) method served as the primary MR analysis. Heterogeneity testing and sensitivity analysis were also conducted.</p><h3>Results</h3><p>Our results denoted a genetic association between the frailty index with an increased risk of OA, the odds ratio (OR)_IVW in the UKB was 1.03 (95% confidence interval [CI]: 1.01–1.05; <i>P</i> = 0.007), and OR_IVW was 1.55 (95% CI: 1.16–2.07; <i>P</i> = 0.003) in the FinnGen. For RA, the OR_IVW from UKB and FinnGen were 1.03 (1.01–1.05, <i>P</i> = 0.006) and 4.57 (1.35–96.49; <i>P</i> = 0.025) respectively. For PSA, the frailty index was associated with PSA (OR_IVW = 4.22 (1.21–14.67), <i>P</i> = 0.023) in FinnGen, not in UKB (<i>P</i> &gt; 0.05). However, no association was found between frailty index and AS (<i>P</i> &gt; 0.05). These results remained consistent across sensitivity assessments.</p><h3>Conclusion</h3><p>This study demonstrated a potential causal relationship that genetic predisposition to frailty index was associated with the risk of arthritis, especially RA, OA, and PSA, not but AS. Our findings enrich the existing body of knowledge on the subject matter.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"36 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}