Clinical significance of serum irisin, 25(OH)D3 and albumin in older adults with chronic disease and sarcopenia

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-05-16 DOI:10.1007/s40520-025-03051-2

Yuxia Ma, Yi Liu, Jiachuang Zheng, Zhixia Zheng, Jingjing Li

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Abstract

Background

Sarcopenia, characterized by progressive muscle mass and strength decline, poses a significant health challenge among older adults, especially those with chronic diseases. Our study aims to evaluate the combined diagnostic potential of irisin, 25(OH)D3, and albumin for sarcopenia in older patients with chronic conditions.

Methods

A cohort of 393 older patients with chronic diseases, including 117 diagnosed with sarcopenia were included. Fasting blood samples were collected, and serum biomarkers (25(OH)D3, albumin, and irisin) were measured using automated biochemical analyzers and enzyme-linked immunosorbent assay to evaluate nutritional and muscle-related parameters.

Results

The prevalence of sarcopenia was higher among patients aged 80 or older compared to younger age groups in our study population. Strong associations were observed between sarcopenia and osteoporosis, tumors, and risk of malnutrition. Serum irisin, 25(OH)D3, and albumin levels were significantly lower in sarcopenic patients. Individual biomarkers displayed diagnostic potential, and a combined biomarker test showed superior accuracy. Multivariate logistic regression identified age, osteoporosis, malnutrition, and fatigue as independent risk factors, while higher serum biomarker levels correlated with reduced sarcopenia risk. Positive correlations were observed between serum biomarkers and sarcopenia severity indicators.

Conclusions

This study highlights the potential of irisin, 25(OH)D3, and albumin as diagnostic and prognostic tools for sarcopenia in older patients with chronic diseases, contributing to early detection and intervention strategies to enhance their quality of life.

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血清鸢尾素、25(OH)D3和白蛋白在老年慢性病和肌肉减少症患者中的临床意义

骨骼肌减少症以肌肉质量进行性下降和力量下降为特征，对老年人，特别是慢性病患者的健康构成了重大挑战。我们的研究旨在评估鸢尾素、25(OH)D3和白蛋白对老年慢性疾病患者肌肉减少症的联合诊断潜力。方法纳入393例老年慢性疾病患者，其中117例诊断为肌肉减少症。采集空腹血液样本，使用自动生化分析仪和酶联免疫吸附法测量血清生物标志物（25(OH)D3、白蛋白和鸢尾素），以评估营养和肌肉相关参数。结果在我们的研究人群中，80岁及以上患者的肌肉减少症患病率高于年轻人群。骨骼肌减少症与骨质疏松症、肿瘤和营养不良风险之间存在很强的相关性。肌少症患者血清中鸢尾素、25(OH)D3和白蛋白水平显著降低。单个生物标志物显示出诊断潜力，联合生物标志物测试显示出更高的准确性。多因素logistic回归发现年龄、骨质疏松、营养不良和疲劳是独立的危险因素，而较高的血清生物标志物水平与减少肌肉减少症的风险相关。血清生物标志物与肌少症严重程度指标呈正相关。结论：本研究强调了鸢尾素、25(OH)D3和白蛋白作为老年慢性疾病患者肌肉减少症的诊断和预后工具的潜力，有助于早期发现和干预策略，以提高他们的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.