Probable sarcopenia and depressive symptoms in community-dwelling older adults: exploring the role of frailty and comorbidities

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-03-25 DOI:10.1007/s40520-025-03005-8

Emanuele Rocco Villani, Andrea Salerno, Federico Triolo, Laura Franza, Giulia Vaccari, Barbara Manni, Antonella Rita Vaccina, Lucia Bergamini, Vanda Menon, Davide Zaccherini, Andrea Fabbo

{"title":"Probable sarcopenia and depressive symptoms in community-dwelling older adults: exploring the role of frailty and comorbidities","authors":"Emanuele Rocco Villani, Andrea Salerno, Federico Triolo, Laura Franza, Giulia Vaccari, Barbara Manni, Antonella Rita Vaccina, Lucia Bergamini, Vanda Menon, Davide Zaccherini, Andrea Fabbo","doi":"10.1007/s40520-025-03005-8","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Sarcopenia is a syndrome characterized by the loss of skeletal muscle associated with reduced physical strength/performance and could be correlated with depression, that is the most frequent cause of emotional distress in old age and can reduce the quality of life of the older adults.</p><h3>Aim</h3><p>The aim of the present study is to evaluate the association between probable sarcopenia and depressive symptoms in older adults, and the impact of comorbidity and frailty on this association.</p><h3>Methods</h3><p>This cross-sectional study included community-dwelling older adults at their first geriatric evaluation. Probable sarcopenia was screened according to SARC-F. Clinically significant depressive symptoms (CSDS) were assessed according to the 5-items geriatric depression scale (GDS.) Frailty was determined through the CHSA-clinical frailty scale (CFS). Comorbidity burden was scored through the Cumulative Illness Rating Scale-Geriatric (CIRS-CI).</p><h3>Results</h3><p>We included 238 participants with a mean age of 82.4 (± 6.9) years of age, 152 (63.6%) participants were females. Probable sarcopenia was diagnosed in 131 (55.0%) participants, while CSDS were present in 186 (78.2%) participants. In the multiadjusted model, probable sarcopenia was associated with a higher likelihood of CSDS (OR 2.70, 95% CI 1.03–6.12). No significant interaction of frailty and CIRS were found on the association between probable sarcopenia and CSDS.</p><h3>Conclusions</h3><p>Sarcopenia and depressive symptomatology are highly co-occurring in geriatric patients, and this association may be independent of frailty and comordibity burden.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03005-8.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Clinical and Experimental Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s40520-025-03005-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Sarcopenia is a syndrome characterized by the loss of skeletal muscle associated with reduced physical strength/performance and could be correlated with depression, that is the most frequent cause of emotional distress in old age and can reduce the quality of life of the older adults.

Aim

The aim of the present study is to evaluate the association between probable sarcopenia and depressive symptoms in older adults, and the impact of comorbidity and frailty on this association.

Methods

This cross-sectional study included community-dwelling older adults at their first geriatric evaluation. Probable sarcopenia was screened according to SARC-F. Clinically significant depressive symptoms (CSDS) were assessed according to the 5-items geriatric depression scale (GDS.) Frailty was determined through the CHSA-clinical frailty scale (CFS). Comorbidity burden was scored through the Cumulative Illness Rating Scale-Geriatric (CIRS-CI).

Results

We included 238 participants with a mean age of 82.4 (± 6.9) years of age, 152 (63.6%) participants were females. Probable sarcopenia was diagnosed in 131 (55.0%) participants, while CSDS were present in 186 (78.2%) participants. In the multiadjusted model, probable sarcopenia was associated with a higher likelihood of CSDS (OR 2.70, 95% CI 1.03–6.12). No significant interaction of frailty and CIRS were found on the association between probable sarcopenia and CSDS.

Conclusions

Sarcopenia and depressive symptomatology are highly co-occurring in geriatric patients, and this association may be independent of frailty and comordibity burden.

查看原文本刊更多论文

社区居住老年人可能的肌肉减少症和抑郁症状：探索虚弱和合并症的作用

骨骼肌减少症是一种以骨骼肌丧失为特征的综合征，其特征与体力/表现下降有关，并可能与抑郁症有关，后者是老年人情绪困扰的最常见原因，并可能降低老年人的生活质量。目的本研究的目的是评估老年人可能的肌肉减少症与抑郁症状之间的关系，以及合并症和虚弱对这种关系的影响。方法本横断面研究包括首次进行老年评估的社区居住老年人。根据SARC-F筛查可能的肌肉减少症。采用5项老年抑郁量表（GDS）评定临床显著性抑郁症状（CSDS）。通过chsa -临床虚弱量表（CFS）确定虚弱程度。共病负担通过累积疾病评定量表-老年（CIRS-CI）进行评分。结果238例参与者，平均年龄82.4（±6.9）岁，其中152例（63.6%）为女性。131名（55.0%）参与者被诊断为可能的肌肉减少症，而186名（78.2%）参与者存在CSDS。在多重校正模型中，可能的肌肉减少症与较高的CSDS可能性相关（OR 2.70, 95% CI 1.03-6.12）。在可能的肌肉减少症和CSDS之间没有发现虚弱和CIRS的显著相互作用。结论骨骼肌减少症和抑郁症状在老年患者中高度共存，这种关联可能独立于虚弱和共病负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.