Aging Clinical and Experimental Research最新文献

{"title":"Imaging without biology: limitations of CT-derived psoas muscle volume as a standalone diagnostic criterion for sarcopenia","authors":"Harsh Jain,&nbsp;Samarth Mittal,&nbsp;Buddhadev Chowdhury","doi":"10.1007/s40520-026-03395-3","DOIUrl":"10.1007/s40520-026-03395-3","url":null,"abstract":"<div>\u0000 \u0000 <p>We comment on the study by Choi et al., which proposes CT-derived psoas muscle volume (PV) as a diagnostic indicator for sarcopenia. The study is well designed, using automated deep-learning-based CT segmentation for psoas muscle volume measurement, and adds to the growing interest in opportunistic CT-based muscle assessment. However, a few points may warrant consideration before wider clinical application. These include differences from current consensus definitions of sarcopenia, limitations related to the use of BIA as a reference standard, and the lack of validation against clinical outcomes. Furthermore, volumetric measures alone may not fully capture the histopathological changes associated with sarcopenia, including muscle fibre atrophy, fat infiltration, and neuromuscular denervation. We also note that applying T-score thresholds from osteoporosis to muscle volume is not straightforward, as no comparable outcome data currently exist to anchor these cut-offs in sarcopenia.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sempreverdità (evergreen vitality): a resilience-based, trajectory-oriented extension of healthy ageing","authors":"Davide Maria Andreucci,&nbsp;Virginia Boccardi","doi":"10.1007/s40520-026-03397-1","DOIUrl":"10.1007/s40520-026-03397-1","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between weight-adjusted waist and incidence of low back pain: evidence from the China Health and Retirement Longitudinal Study","authors":"Xueru Shen,&nbsp;Dexin Hu,&nbsp;Yixing Lu,&nbsp;Lixin Zhao,&nbsp;Hua Yuan,&nbsp;Xiaolong Sun","doi":"10.1007/s40520-026-03351-1","DOIUrl":"10.1007/s40520-026-03351-1","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><p>The weight-adjusted waist index (WWI), a novel adiposity metric, provides precise assessment of abdominal fat accumulation. This longitudinal study aims to examine the association between WWI and incident low back pain (LBP) risk in middle-aged and older Chinese adults.</p><h3>Methods</h3><p>Data from the China Health and Retirement Longitudinal Study (CHARLS) (2011–2020) were utilized. Cox proportional hazards models were employed to assess WWI’s association with incident LBP, while restricted cubic splines (RCS) modeled their potential nonlinear relationship. Kaplan-Meier curves were generated to estimate LBP-free probabilities across WWI strata. Sensitivity analyses included multiple imputation and subgroup analyses.</p><h3>Results</h3><p>A total of 3,912 individuals were included in the study. After full adjustment for covariates, each 1-unit increase in WWI within the highest WWI quintile was associated with an 18.6% elevated risk of incident LBP (HR = 1.186, 95% CI: 1.057–1.331). Further analysis revealed a J-shaped association between WWI and incident LBP risk, whereby each 1-unit increment above 10.56 corresponded to a significant 9.6% risk increase (HR = 1.096, 95% CI: 1.026–1.171). A lower probability of remaining LBP-free was observed in the highest WWI quintile group (Q5) relative to other groups (<i>p</i> = 0.00018). Additionally, no statistically significant interaction effects were observed across subgroups (all interaction <i>P</i> &gt; 0.05).</p><h3>Discussions &amp; Conclusions</h3><p>In the Q5, WWI demonstrated an independent association with incident LBP. A critical risk threshold of WWI = 10.56 was established, suggesting the potential of WWI as a screening tool.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-026-03351-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationships between malnutrition, dehydration, frailty, and sarcopenia in older adults with proximal femur fractures: a prospective observational study","authors":"Belinda Trobec,&nbsp;Gianluca Canton,&nbsp;Emma Spedicato,&nbsp;Eleonora Wabitsch,&nbsp;Paolo De Colle,&nbsp;Michela Zanetti,&nbsp;Andrea Marchetti,&nbsp;Luigi Murena,&nbsp;Chiara Ratti","doi":"10.1007/s40520-026-03364-w","DOIUrl":"10.1007/s40520-026-03364-w","url":null,"abstract":"<div><h3>Background</h3><p>Proximal femur fractures (PFFs) are a hallmark of frailty in patients aged ≥ 65 years. Geriatric frailty is multifactorial, with malnutrition, dehydration, and sarcopenia negatively impacting outcomes after PFF.</p><h3>Aims</h3><p>The primary aim of this study was to examine the interrelationships between frailty, malnutrition, hydration status, and ultrasound-defined muscle impairment in older patients with proximal femur fracture. As a secondary objective, we explored the association of these vulnerability domains with 3-month mortality as an exploratory outcome.</p><h3>Methods</h3><p>In this prospective observational study, 108 consecutive patients aged ≥ 65 years undergoing surgical treatment for PFF at Cattinara Hospital (Trieste) were evaluated. Clinical, nutritional (MNA, MUST), functional (ADL, CFS, NHFS, MPI), cognitive (SPMSQ), and dehydration (CDS) assessments were performed. Ultrasound sarcopenia index (USI) measurements were obtained in both upper and lower limbs of 78 patients.</p><h3>Results</h3><p>Mean age was 85.9 ± 6.6 years. Malnutrition, clinical dehydration, and frailty were present in 2.7%, 38%, and 56% of patients, respectively. Among patients assessed by ultrasound, 39% showed sarcopenic features. Nutritional status was significantly associated with frailty, dehydration, ultrasound-defined sarcopenia, and calf circumference (<i>p</i> &lt; 0.05). At univariate analysis, poorer nutritional, cognitive, and functional status, frailty, and preoperative complications were associated with higher 3-month mortality, whereas surgery within 72 h was protective.</p><h3>Discussion</h3><p>Malnutrition, dehydration, and sarcopenia frequently coexist and are closely correlated with geriatric frailty and mortality in patients aged ≥ 65 years with PFF.</p><h3>Conclusions</h3><p>These findings support the relevance of a comprehensive orthogeriatric assessment to better characterize biological vulnerability and guide perioperative care.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and joint associations of psychological resilience and social support with cognitive impairment among middle-aged and older Chinese adults","authors":"Xiaoxia Wei,&nbsp;Fangqin Tan,&nbsp;Weihao Shao,&nbsp;Ji Zhang,&nbsp;Yihao Zhao,&nbsp;Yue Zhang,&nbsp;Jean-Pierre Michel,&nbsp;Enying Gong,&nbsp;Philipe de Souto Barreto,&nbsp;Ruitai Shao","doi":"10.1007/s40520-026-03348-w","DOIUrl":"10.1007/s40520-026-03348-w","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive impairment poses a major public health concern in ageing societies. This study investigated the independent and joint associations of resilience and social support with cognitive function among community-dwelling middle-aged and older Chinese adults, and explored gender-specific differences.</p><h3>Methods</h3><p>A total of 3,058 Chinese adults aged ≥ 50 years from both urban and rural communities were included. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Resilience was assessed using the 10-item Connor-Davidson Resilience Scale (CD-RISC-10), and social support by the 6-item Lubben Social Network Scale (LSNS-6). Logistic regression models stratified by gender were applied with adjustment for demographic, behavioral, and health-related variables. Generalized additive models were used to test non-linear associations, and joint effects were examined with combined categories.</p><h3>Results</h3><p>Overall, 18.4% of participants (20.1% women, 16.3% men) had cognitive impairment. Higher resilience and social support were independently associated with lower odds of cognitive impairment, with some variation in effect strength across sex, age group, and educational attainment in sensitivity and stratified analyses. Curvilinear associations were observed in generalized additive models. Compared with low resilience and low support, participants with moderate resilience and high support had the lowest risk (OR = 0.25, 95% CI: 0.11–0.51).</p><h3>Conclusions</h3><p>Resilience and social support were independently and jointly associated with cognitive function among middle-aged and older adults. These associations appeared to be stronger in women, although variation by sex was observed. Given the cross-sectional design, the findings should be interpreted as exploratory, and further longitudinal and interventional studies are needed to clarify the role of psychosocial resources in cognitive ageing.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very short-term monitoring of Romosozumab longitudinal effects in a cohort of postmenopausal women by means of Radiofrequency Echographic Multi-Spectrometry (REMS) technology","authors":"Angelo Semeraro,&nbsp;Angela Chialà,&nbsp;Andrea Carafa,&nbsp;Rosalinda Fanizzi,&nbsp;Elisabetta Di Tano,&nbsp;Maria Palmisano,&nbsp;Carmela Santoro,&nbsp;Federica Dibenedetto,&nbsp;Nicola Napoli","doi":"10.1007/s40520-026-03391-7","DOIUrl":"10.1007/s40520-026-03391-7","url":null,"abstract":"<div><h3>Background</h3><p>Romosozumab/AMG785 (Evenity^®, Amgen and UCB pharma, RMZ) is a sclerostin-neutralizing antibody that rapidly increases BMD, but very short-term monitoring in clinical routine is limited by specific issues of available ionizing techniques.</p><h3>Aims</h3><p>To assess the effectiveness of the radiation-free Radiofrequency Echographic Multi Spectrometry (REMS) for very short-term monitoring of RMZ in postmenopausal women.</p><h3>Methods</h3><p>Seventy-four postmenopausal women starting RMZ and 52 postmenopausal women not receiving anti-osteoporosis drugs underwent proximal femur REMS scans at baseline and after 6 months, assessing total hip (TH) and femoral neck (FN) BMD. Exploratory analyses were also performed in treatment-naïve patients and in women with ≥ 2 prior fragility fractures.</p><h3>Results</h3><p>After six months of RMZ, BMD significantly increased at both TH (+ 3.7%; 0.718 ± 0.103 g/cm² vs. 0.698 ± 0.116 g/cm²; <i>p</i> &lt; 0.01) and FN (+ 4.1%, 0.572 ± 0.092 g/cm² vs. 0.556 ± 0.105 g/cm²; <i>p</i> ≤ 0.01). In treatment-naïve patients (<i>n</i> = 33), BMD gains were larger (TH + 4.7%; FN + 4.6%), as also in women with ≥ 2 prior fractures (<i>n</i> = 36), where TH BMD increased by 4.1% and FN BMD by 4.8%. In untreated controls, no significant changes were observed at either TH (-0.8%; <i>p</i> &gt; 0.05) or FN (-0.6%; <i>p</i> &gt; 0.05). Weight and BMI did not change significantly over the considered 6-month interval.</p><h3>Conclusions</h3><p>REMS detected clinically-relevant 6-month increases in femoral BMD during RMZ therapy, while BMD remained stable in untreated controls. These findings, together with anthropometric stability, support the feasibility of REMS for very short-term follow-up in real-world settings.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption and brain structure: a comprehensive systematic review of observational studies","authors":"Justyna Godos,&nbsp;Giuseppe Caruso,&nbsp;Agnieszka Micek,&nbsp;Alberto Dolci,&nbsp;Zoltan Ungvari,&nbsp;Andrea Lehoczki,&nbsp;Lisandra Leon,&nbsp;Evelyn Frias-Toral,&nbsp;Andrea Di Mauro,&nbsp;Mario Siervo,&nbsp;Michelino Di Rosa,&nbsp;Giuseppe Grosso","doi":"10.1007/s40520-026-03363-x","DOIUrl":"10.1007/s40520-026-03363-x","url":null,"abstract":"<div><h3>Background</h3><p>Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel–related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking.</p><h3>Aims</h3><p>The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies.</p><h3>Methods</h3><p>Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations.</p><h3>Results</h3><p>A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet).</p><h3>Conclusions</h3><p>Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac resynchronization therapy in very old patients with pacemakers: a cardiogeriatric, physiology-based approach","authors":"Rémi Esser,&nbsp;Marc Harboun,&nbsp;Alejandro Mondragon,&nbsp;Marine Larbaneix,&nbsp;Christine Farges,&nbsp;Marlène Esteban,&nbsp;Vincenzo Palermo,&nbsp;Sophie Nisse Durgeat,&nbsp;Olivier Maurou,&nbsp;David Perrot","doi":"10.1007/s40520-026-03393-5","DOIUrl":"10.1007/s40520-026-03393-5","url":null,"abstract":"<div>\u0000 \u0000 <p>Cardiac resynchronization therapy (CRT) is an established treatment for selected patients with heart failure (HF), yet its role in advanced age remains insufficiently defined. Adults aged ≥ 80 years are markedly underrepresented in randomised trials, frequently present with multimorbidity and frailty, and often develop HF related to pacing-related mechanisms, including pacing-induced cardiomyopathy (with LVEF decline) and pacing-related dyssynchrony that is not fully addressed by guideline-based algorithms. In this context, CRT implantation or upgrade represents a complex cardiogeriatric decision rather than a purely electrophysiological intervention. This narrative review examines the physiological rationale, available evidence, and clinical challenges of CRT in advanced-age populations, illustrated by a representative clinical vignette of pacemaker-induced HF. We discuss age-related myocardial vulnerability, secondary mitral regurgitation, competing mortality risks, and the predominance of functional and quality-of-life outcomes over survival endpoints. Particular emphasis is placed on integrating geriatric domains—frailty, functional status, cognition, and proportionality of care—into CRT decision-making. We explicitly distinguish pacing-induced cardiomyopathy (with reduced LVEF) from isolated pacing-related dyssynchrony; in patients with preserved LVEF, congestion is more often driven by a severe haemodynamic substrate—particularly valve dysfunction—than by dyssynchrony alone. In selected older adults, CRT may provide meaningful symptomatic and functional benefit when HF is driven by potentially reversible dyssynchrony, even if survival gains are limited. A cardiogeriatric, physiology-based approach may help identify patients most likely to benefit from CRT while avoiding disproportionate interventions in individuals with advanced frailty or limited physiological reserve.</p>\u0000 </div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory research on cognitive fluency design for the older adults through Nostalgia-based empowerment","authors":"Yingjia Zhou,&nbsp;Xianhua Sun","doi":"10.1007/s40520-026-03396-2","DOIUrl":"10.1007/s40520-026-03396-2","url":null,"abstract":"<div><h3>Background</h3><p>As global aging intensifies, issues in age-friendly cultural consumption design have become increasingly apparent. Existing age-friendly designs primarily focus on simplifying functions while neglecting cognitive fluency, resulting in the current dilemma of “high demand-low adoption.”</p><h3>Purpose</h3><p>To systematically validate the impact of cognitive fluency design, empowered by nostalgia, on age-friendly cultural consumption through a three-dimensional cognitive-physiological-psychological framework.</p><h3>Methods</h3><p>Extensive literature searches and data collection were conducted across electronic databases including Web of Science, PubMed, and CNKI. This was followed by field research and interviews using questionnaire surveys. Findings were further refined through data analysis to advance research on cognitive fluency design for aging-friendly.This study is exploratory in nature, with a relatively small sample size, and the conclusions primarily provide preliminary reference and ideas for subsequent related research.</p><h3>Results</h3><p>Findings demonstrate that in terms of emotional activation, nostalgic design effectively triggers pleasant feelings and enhances cognitive fluency among older adults. This approach yields multifaceted benefits for their physical and mental well-being, with particularly significant effects on orientation, memory, and fluency. This intervention pathway is crucial in research on cognitive fluency in aging.</p><h3>Conclusion</h3><p>Cognitive fluency design is the key variable in overcoming the ‘last mile’ of age-friendly adaptation, and it needs to be supported by nostalgia-empowerment strategies to aid contemporary age-friendly design.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and prescribing patterns of antiosteoporosis medicines in Chinese patients: a real-world retrospective study","authors":"Shuo Zhang,&nbsp;Yuqing Fan,&nbsp;Mengyao Xue,&nbsp;Linfeng Jiang,&nbsp;Chen Mu,&nbsp;Nan Peng,&nbsp;Dongning Yao","doi":"10.1007/s40520-026-03382-8","DOIUrl":"10.1007/s40520-026-03382-8","url":null,"abstract":"<div><h3>Background</h3><p>The availability of new anti-osteoporosis medications (AOMs) and updates to clinical guidelines in recent years may have substantially influenced real-world prescribing patterns.</p><h3>Aims</h3><p>To assess trends in the utilization, prescribing patterns of AOMs and related influencing factors in Eastern China.</p><h3>Methods</h3><p>Patients with osteoporosis who had at least one prescription for AOMs were identified from a provincial healthcare database in Eastern China (2019–2024). Patients were followed until the occurrence of Paget’s disease, malignant tumors, death, loss to follow-up, or October 29, 2024. The prescribing patterns and utilization trends of AOMs were analyzed. Multivariate logistic regression was performed to identify factors influencing AOMs choice.</p><h3>Results</h3><p>A total of 363,529 patients were included (mean age 65.1 years; 73.0% female). Active vitamin D analogs (71.9%), bisphosphonates (22.0%), traditional Chinese medicine (TCM) (15.3%) and denosumab (14.2%) were the most commonly prescribed AOMs. The use of denosumab increased significantly (2.9% vs. 21.8%, <i>P</i> &lt; 0.001), while active vitamin D analogs (80.0% vs. 64.8%, <i>P</i> &lt; 0.001), bisphosphonate (26.9% vs. 16.7%, <i>P</i> &lt; 0.001) and TCM (15.3% vs. 11.6%, <i>P</i> &lt; 0.001) declined from 2019 to 2024. Most patients received monotherapy (92.2%), with only 7.8% receiving combination therapy. The most frequent combination was vitamin D and analogs with bisphosphonates (55.6%). Women, older adults, and those with fracture history were more likely to receive calcitonin and denosumab, but less likely to receive vitamin D analogs.</p><h3>Conclusions</h3><p>Osteoporosis treatment was predominantly monotherapy, with active vitamin D analogs being the most commonly prescribed agents, followed by bisphosphonates, TCM, and denosumab. Attention should be given to weak evidence-based TCM use.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"38 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}