Russian Journal of Organic Chemistry最新文献_第6页

Design and Synthesis of Some Novel Phosphorus Heterocycles-Based Coumarin Derivatives as Promising Anticancer Agents 新型磷杂环香豆素类抗癌药物的设计与合成

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130268

N. M. Hassanin, T. E. Ali, M. A. Assiri, S. M. Abdel-Kariem

引用次数: 0

Solvent-Free Synthesis of Pyrazole Derivatives Mediated by Cobalt-Doped Iron Tartarate 掺杂钴酒石酸铁介导的吡唑衍生物的无溶剂合成

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130013

S. B. Jagtap, A. S. Patki, D. B. Muley

引用次数: 0

Efficient Synthesis of Bis(indolyl)methane Compounds in the Presence of Recyclable Nickel Oxide/Alumina Nanocatalyst 可回收氧化镍/氧化铝纳米催化剂下双（吲哚基）甲烷化合物的高效合成

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130190

Bita Baghernejad, Hamoun Naseri, O. Marvi

{"title":"Efficient Synthesis of Bis(indolyl)methane Compounds in the Presence of Recyclable Nickel Oxide/Alumina Nanocatalyst","authors":"Bita Baghernejad, Hamoun Naseri, O. Marvi","doi":"10.1134/S1070428024130190","DOIUrl":"10.1134/S1070428024130190","url":null,"abstract":"Bis(indolyl)methane derivatives, known for anticancer, antimicrobial, and antioxidant properties, have garnered significant research interest. This study reports an efficient and environmentally friendly method for synthesizing bis(indolyl)methanes via a one-pot reaction between indole and aromatic aldehydes using a nickel oxide/alumina nanocatalyst. The catalyst was prepared by co-precipitation of nickel nitrate hexahydrate and urea in the presence of γ-Al2O3, followed by calcination, and characterized using TEM and SEM techniques to confirm its nanoscale morphology. The reactions were performed in water as a solvent under reflux conditions, giving high product yields (up to 97%) within short reaction times (15 min). All the catalyst is inferior of the known CeO2 catalyst, it allows the use of water instead of chloroform as a solvent. The catalyst was successfully recycled up to five times without significant loss in efficiency, demonstrating its stability and reusability. Experimental methods included monitoring the reaction progress using thin-layer chromatography and product characterization by IR and NMR spectroscopy. The proposed method for the synthesis of bis(indolyl)methane derivatives offers advantages such as simple product separation, low catalyst consumption, and minimal purification losses, presenting a sustainable and effective approach for the synthesis of bis(indolyl)methanes.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S147 - S151"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Greener and Economical Synthesis of Hexahydroacridine-1,8(2H,5H)-diones Using 2-Aminopyrazine Catalyst Through Mortar-Pestle Grinding Approach with Their Computational Study 以2-氨基吡嗪为催化剂，采用研钵法合成六氢吖啶-1,8(2H,5H)-二酮及其计算研究

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130128

Harish Kumar Edapu, Sathyanarayana Boodida, Ramakanth Pagadala, Thirupathi Damera

引用次数: 0

Design, Synthesis, and Antioxidant Studies of Newer 4′-(3-Substituted Phenyl-6,6-dimethyl-4-oxo-2,3,5,7-tetrahydrobenzofuran-2-yl)-[1,1′-biphenyl]-2-carbonitriles: Adaptability of Sartans Drug Reactant 新型4 ' -（3-取代苯基-6,6-二甲基-4-氧-2,3,5,7-四氢苯并呋喃-2-基）-[1,1 ' -联苯]-2-碳腈的设计、合成及抗氧化研究：对Sartans药物反应物的适应性

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130153

M. Bhatt, J. H. Kamdar, J. Upadhyay

{"title":"Design, Synthesis, and Antioxidant Studies of Newer 4′-(3-Substituted Phenyl-6,6-dimethyl-4-oxo-2,3,5,7-tetrahydrobenzofuran-2-yl)-[1,1′-biphenyl]-2-carbonitriles: Adaptability of Sartans Drug Reactant","authors":"M. Bhatt, J. H. Kamdar, J. Upadhyay","doi":"10.1134/S1070428024130153","DOIUrl":"10.1134/S1070428024130153","url":null,"abstract":"A one-pot reaction of dimedone, 4′-(bromomethyl)-[1,1′-biphenyl] was used to produce a variety of tetrahydrobenzofuran-4(2H)-one derivatives 4a–4j in acetonitrile using pyridine and triethylamine as an economic catalyst under mild reaction conditions. The designed approach involves the formation of three bonds: two C–C bonds and one C–O bond. A greater yield and exceptional purity were achieved for all of the compounds. Several techniques were employed to study the benzofurans that were synthesized from sartan series benzyl bromide fragments. These techniques included FTIR, 1H, 13C NMR, and MS. The antioxidant capabilities of the synthetic chemicals were evaluated through screening. Substituents in benzaldehyde fragments as dimethoxy (4f), trimethoxy (4g), and nitro (4h) groups exhibited increased efficacy in a controlled laboratory setting utilizing the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical assay, with IC50 values of 14, 16, and 15 µM, respectively. In contrast to the standard (ascorbic acid, IC50 =14.06 µM), compounds containing halogen substituents were discovered to be somewhat effective in the free radical scavenging experiment. They identified a strong correlation between their binding modalities and the antioxidant characteristics in their molecular docking experiment with the myeloperoxidase (PDB: 3MNG) enzyme, which showed high binding affinities (docking score = –19.2 kcal/mol for 4f).","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S112 - S120"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imidazol-1,2,3-triazole Derivatives as Novel and Potent Scaffolds of α-Glucosidase Inhibitors: Synthesis and Biological Evaluations 咪唑-1,2,3-三唑衍生物作为α-葡萄糖苷酶抑制剂的新型有效支架：合成和生物学评价

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130244

Krishna K. Limbasiya, Jayesh S. Babariya, Vasta A. Modhavadiya

{"title":"Imidazol-1,2,3-triazole Derivatives as Novel and Potent Scaffolds of α-Glucosidase Inhibitors: Synthesis and Biological Evaluations","authors":"Krishna K. Limbasiya, Jayesh S. Babariya, Vasta A. Modhavadiya","doi":"10.1134/S1070428024130244","DOIUrl":"10.1134/S1070428024130244","url":null,"abstract":"A treatment for type 2 diabetes mellitus (T2DM) that has been approved is the inhibition of α-glucosidase. Using a simple and straightforward three-step synthetic route that utilized a Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry approach in the last step, a new series of substituted 1H-imidazol-1H-1,2,3-triazoles, specifically 5a–5j, were synthesized in an effort to create new anti-α-glucosidase agents. 1H and 13C NMR spectroscopy and mass spectrometry were used to characterize these motifs in great detail. The positive control in this investigation was acarbose, which had an IC50 value of 750.0 µM. The 1H-imidazol-1H-1,2,3-triazoles that were replaced showed inhibitory potencies several times stronger than those of conventional medicines, with IC50 values ranging from 14.89 to 311.20 μM. In particular, compounds containing fluorine groups as aryl substitutions exhibited anti-α-glucosidase activity with an IC50 value of 14.89 μM (5f = 4-CF3), which was 53 times stronger than the positive control acarbose, while compounds carrying the 2,4-(F)2 motif had an IC50 value of 29.50 μM, which was 25 times stronger.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S205 - S212"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Microwave-Assisted Synthesis, Characterization, and Antimicrobial Proficiency of Pyranopyrazole-Based Quinoline Derivatives 以吡喃吡唑为基础的喹啉衍生物的微波合成、表征和抗菌能力研究

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130098

Dharmesh K. Katariya, Amita K. Vyas, Ranjan C. Khunt

引用次数: 0

Synthesis and Biological Evaluation of Coumarin Bearing Thiourea Derivative as Potential Antibacterial Agent 含硫脲类香豆素衍生物潜在抗菌剂的合成及生物学评价

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130177

Alim Alsukor, Nurul Alam Inayatsyah, Sharifah Aminah Syed Mohamad, Mohamad Jemain Mohamad Ridhwan, Nurulfazlina Edayah Rasol, Syahrul Imran

{"title":"Synthesis and Biological Evaluation of Coumarin Bearing Thiourea Derivative as Potential Antibacterial Agent","authors":"Alim Alsukor, Nurul Alam Inayatsyah, Sharifah Aminah Syed Mohamad, Mohamad Jemain Mohamad Ridhwan, Nurulfazlina Edayah Rasol, Syahrul Imran","doi":"10.1134/S1070428024130177","DOIUrl":"10.1134/S1070428024130177","url":null,"abstract":"In this study, a series of thiourea-substituted coumarin was synthesized in a four-step reaction from a precursor, 2-oxo-2H-chromene-3-carboxylic acid. The structures of all synthesized compounds were confirmed using NMR and LCMS. All synthesized compounds were screened for their antibacterial activity against gram-negative (Escherichia coli, Salmonella typhimurium, and Enterobacter aerogenes) and gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria strains using well diffusion method. Most of the synthesized compounds were found to be susceptible to most of the tested bacterial strains. The structure-activity relationship showed that compounds with substituents at the ortho position had lower overall activity as compared to meta-substituted and para-substituted compounds. Compound 19 was found to be the most effective antibacterial agent against gram-positive S. aureus and B. subtilis, with minimum inhibitory concentration values of 31.25 and 62.50 µg/mL, respectively. Molecular docking performed on potential compounds revealed significant binding site interaction with S. aureus gyrase residue Asp1083 and Met1121.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S128 - S139"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Heterocyclic Ligand and Its Metal Complexes 杂环配体及其金属配合物的合成与表征

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130062

K. Ramya Charitha, R. Mamatha Rani, P. Kavitha

引用次数: 0

Synthesis, Characterization, and Pharmacokinetic Studies of Novel HydroquinoneBased 1,2,3-Triazole/Amide Derivatives as Anticancer and Antibacterial Agents 新型对苯二酚类1,2,3-三唑/酰胺类抗癌和抗菌药物的合成、表征及药代动力学研究

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130086

Syed Nazreen

引用次数: 0