尼美舒利通过（尼美舒利）（3,5-二甲基异恶唑-4-基）碘盐形成的后期C-H功能化

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-07-13 DOI:10.1134/S107042802560192X

D. I. Bugaenko, A. V. Karchava

引用次数: 0

摘要

n -甲基化尼美舒利与以4-碘-3,5-二甲基异恶唑（DMIX-I(OH)OTs）为基料的Koiser试剂反应生成相应的碘盐。这种盐随后与S-、O-和n -亲核试剂相互作用，得到尼美舒利的官能化衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Late-Stage C–H Functionalization of Nimesulide via (Nimesulide)(3,5-dimethylisoxazol-4-yl)iodonium Salt Formation

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Late-Stage C–H Functionalization of Nimesulide via (Nimesulide)(3,5-dimethylisoxazol-4-yl)iodonium Salt Formation

The reaction of N-methylated nimesulide with Koiser’s reagent based on 4-iodo-3,5-dimethylisoxazole (DMIX-I(OH)OTs) yielded the corresponding iodonium salt. Subsequent interaction of this salt with S-, O-, and N-nucleophiles gave functionalized derivatives of nimesulide.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.