Late-Stage C–H Functionalization of Nimesulide via (Nimesulide)(3,5-dimethylisoxazol-4-yl)iodonium Salt Formation
IF 0.9
4区 化学
Q4 CHEMISTRY, ORGANIC
引用次数: 0
Abstract
The reaction of N-methylated nimesulide with Koiser’s reagent based on 4-iodo-3,5-dimethylisoxazole (DMIX-I(OH)OTs) yielded the corresponding iodonium salt. Subsequent interaction of this salt with S-, O-, and N-nucleophiles gave functionalized derivatives of nimesulide.
尼美舒利通过（尼美舒利）（3,5-二甲基异恶唑-4-基）碘盐形成的后期C-H功能化
n -甲基化尼美舒利与以4-碘-3,5-二甲基异恶唑（DMIX-I(OH)OTs）为基料的Koiser试剂反应生成相应的碘盐。这种盐随后与S-、O-和n -亲核试剂相互作用，得到尼美舒利的官能化衍生物。
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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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