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Synthesis of Polysubstituted Furans from α-Substituted 2-Enals
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-27 DOI: 10.1134/S1070428024110095
V. G. Fedoseeva, E. A. Verochkina, L. I. Larina, N. V. Vchislo
{"title":"Synthesis of Polysubstituted Furans from α-Substituted 2-Enals","authors":"V. G. Fedoseeva,&nbsp;E. A. Verochkina,&nbsp;L. I. Larina,&nbsp;N. V. Vchislo","doi":"10.1134/S1070428024110095","DOIUrl":"10.1134/S1070428024110095","url":null,"abstract":"<p>The three-component reaction of cyclohexyl isocyanide, dimethyl acetylenedicarboxylate, and (<i>Z</i>)-3-phenyl-2-(alkylsulfanyl)- or (<i>Z</i>)-3-furyl-2-methoxyprop-2-enals gives polysubstituted furans in good yields.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 11","pages":"2157 - 2161"},"PeriodicalIF":0.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches to the Formation of the Key 2-Oxabicyclo[3.3.0]octan-3-one Precursor of Galiellalactone
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-27 DOI: 10.1134/S107042802411006X
A. M. Gimazetdinov, V. V. Zagitov, Z. R. Makaev
{"title":"Approaches to the Formation of the Key 2-Oxabicyclo[3.3.0]octan-3-one Precursor of Galiellalactone","authors":"A. M. Gimazetdinov,&nbsp;V. V. Zagitov,&nbsp;Z. R. Makaev","doi":"10.1134/S107042802411006X","DOIUrl":"10.1134/S107042802411006X","url":null,"abstract":"<p>New vicinal all-<i>cis</i>-trisubstituted derivatives of cyclopentane- and cyclopentenetriols were synthesized.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 11","pages":"2130 - 2139"},"PeriodicalIF":0.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S107042802411006X.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143107899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-Component Synthesis of Novel 5H-[1,3]dioxolo[4,5-f]indole Derivatives
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-27 DOI: 10.1134/S1070428024110174
Dan-Dan Wan, Ji Li, Jia-Yan Liu, Dong-Sheng Chen
{"title":"Three-Component Synthesis of Novel 5H-[1,3]dioxolo[4,5-f]indole Derivatives","authors":"Dan-Dan Wan,&nbsp;Ji Li,&nbsp;Jia-Yan Liu,&nbsp;Dong-Sheng Chen","doi":"10.1134/S1070428024110174","DOIUrl":"10.1134/S1070428024110174","url":null,"abstract":"<p>New 5<i>H</i>-[1,3]dioxolo[4,5-<i>f</i>]indole derivatives were synthesized in good yields were synthesized by a one-pot, three-component reaction of benzo[<i>d</i>][1,3]dioxol-5-amine, arylglyoxals, and 4-hydroxyquinolin-2(1<i>H</i>)-one in the presence of acetic acid as a catalyst in an ethanol medium under reflux.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 11","pages":"2290 - 2297"},"PeriodicalIF":0.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, Synthesis, and Antibacterial Activity of Morpholine-4-sulfonamide Derivatives
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-27 DOI: 10.1134/S1070428024110149
Huimin Zou, Yi Tan, Zhiyou Huang, Ping Yang, Wenxia Ou, Xiaohong Li
{"title":"Design, Synthesis, and Antibacterial Activity of Morpholine-4-sulfonamide Derivatives","authors":"Huimin Zou,&nbsp;Yi Tan,&nbsp;Zhiyou Huang,&nbsp;Ping Yang,&nbsp;Wenxia Ou,&nbsp;Xiaohong Li","doi":"10.1134/S1070428024110149","DOIUrl":"10.1134/S1070428024110149","url":null,"abstract":"<p>In the search for novel antibacterial agents, a series of <i>N</i>-(substituted nitrophenyl)morpholine-4-sulfonamides were prepared by the reactions of substituted nitrobenzenes with morpholine-4-sulfonamide under MW irradiation. The synthetic approach is characterized by a facile procedure and broad substrate scope. Preliminary biological assessment of the activity of compounds <b>1b–1h</b>, <b>1k–1n</b> against <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> (<i>Xoo</i>) was higher than 80% at 800 μg/mL. Especially, the inhibition rate of compounds <b>1d</b>, <b>1k</b>, and <b>1n</b> were higher than 95%. Significantly, the EC<sub>50</sub> value of <b>1d</b> was close to the sanguinarine.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 11","pages":"2259 - 2265"},"PeriodicalIF":0.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemical Carboxylation with CO2 (A Review)
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-27 DOI: 10.1134/S1070428024110010
Yu. H. Budnikova
{"title":"Electrochemical Carboxylation with CO2 (A Review)","authors":"Yu. H. Budnikova","doi":"10.1134/S1070428024110010","DOIUrl":"10.1134/S1070428024110010","url":null,"abstract":"<p>Carbon dioxide (CO<sub>2</sub>) is a widespread, inexpensive, and renewable source of C1 carbon and the main component of greenhouse gases. Therefore, studies on its efficient conversion into useful products, corresponding to the principles of sustainable development, have received considerable attention in recent years. Electrochemical organic synthesis, as an environmentally friendly, mild, and selective approach, is considered an ideal tool for the utilization of CO<sub>2</sub> and its use as a reagent. This review summarizes recent advances in the field of electrocarboxylation involving CO<sub>2</sub> as a precursor in reactions of various types, which reveal a high potential of such transformations in the synthesis of green organics. Special attention is given to processes at the late stage of functionalization of complex molecules that are promising for use in pharmaceutical chemistry.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 11","pages":"2055 - 2085"},"PeriodicalIF":0.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in (Di)Azafluorene Chemistry (A Review)
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-27 DOI: 10.1134/S1070428024110022
E. B. Rakhimova, V. Yu. Kirsanov
{"title":"Recent Advances in (Di)Azafluorene Chemistry (A Review)","authors":"E. B. Rakhimova,&nbsp;V. Yu. Kirsanov","doi":"10.1134/S1070428024110022","DOIUrl":"10.1134/S1070428024110022","url":null,"abstract":"<p>The review systematizes and summarizes recent results on the synthesis of aza- and diazafluorenes and their physicochemical properties and biological activity.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 11","pages":"2086 - 2107"},"PeriodicalIF":0.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesomorphism in Relation to Laterally Substituted Homologous Series with Azo and Azomethine Linkages 具有偶氮和亚甲基键的横向取代同源序列的亚纯性
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130207
Dhruv P. Darji, Hitendra Mali, Bhavesh R. Pansuriya
{"title":"Mesomorphism in Relation to Laterally Substituted Homologous Series with Azo and Azomethine Linkages","authors":"Dhruv P. Darji,&nbsp;Hitendra Mali,&nbsp;Bhavesh R. Pansuriya","doi":"10.1134/S1070428024130207","DOIUrl":"10.1134/S1070428024130207","url":null,"abstract":"<p>(<i>E</i>)-<i>N</i>-(4-Alkyloxybenzylidene)-4-((<i>E</i>)-phenyldiazenyl)aniline (<b>9a–9e</b>) and (<i>E</i>)-<i>N</i>-(4-alkyloxy-3-methoxybenzylidene)-4-((<i>E</i>)-phenyldiazenyl)aniline (<b>10a–10e</b>), containing –N=N– and –CH=N– linkages, were synthesized and studied for their mesogenic behavior. All synthesized compounds exhibited enantiotropic smectic behavior and followed a typical transition curve. Thermal phase transitions were recorded using a polarizing optical microscope equipped with a heating stage. The structures of the synthesized compounds were confirmed based on <sup>1</sup>H NMR and IR spectral analyses. The introduction of a methoxy (–OCH<sub>3</sub>) substitution at the <i>ortho</i> position in a phenyl ring with a terminal alkyl chain resulted in a lower Cr–Sm phase transition temperature and decreased thermal stability. The average onset of the smectic phase for <b>9a–9e</b> was 55.6°C, whereas for <b>10a–10e</b>, it was 84.2°C. Comparatively, the average thermal stability for the unsubstituted homologous series was 130.2°C, whereas for the methoxy-substituted homologous series, it was 83.4°C.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S152 - S159"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel 1,3,4-Thiadiazole-2-yl-pyrimidine Derivatives In Vitro and the Etymology of Antifungal Activity 新型1,3,4-噻二唑-2-酰基嘧啶衍生物的体外抗真菌活性及词源研究
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130037
B. Andrews, S. Sudarsan, A. Leo Michael Durairaj
{"title":"Novel 1,3,4-Thiadiazole-2-yl-pyrimidine Derivatives In Vitro and the Etymology of Antifungal Activity","authors":"B. Andrews,&nbsp;S. Sudarsan,&nbsp;A. Leo Michael Durairaj","doi":"10.1134/S1070428024130037","DOIUrl":"10.1134/S1070428024130037","url":null,"abstract":"<p>An array of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenyl-pyrimidin-2(1<i>H</i>)-one derivatives (<b>3a</b>–<b>3j</b>) were synthesized. The synthesized chemicals effectively suppressed fungus activities. IR, <sup>1</sup>H, <sup>13</sup>C NMR, GC-MS, and Elemental analysis techniques were used to analyze the structures of the newly synthesized compounds. The majority of substances, compared to standard Amphotericin-B, have demonstrated promising antifungal activity.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S22 - S27"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Synthesis of Bioactive Polyhydroquinoline Derivatives via Hantzsch Condensation Using Sulfanilic Acid as a Versatile and Efficient Catalyst 以磺胺酸为高效催化剂，Hantzsch缩合法绿色合成生物活性聚对苯二酚衍生物
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130165
Manoj P. Palve, Jaysing M. Dinore, Amol V. Sapkal, Ajeet A. Yelwande, Rajita D. Ingle
{"title":"Green Synthesis of Bioactive Polyhydroquinoline Derivatives via Hantzsch Condensation Using Sulfanilic Acid as a Versatile and Efficient Catalyst","authors":"Manoj P. Palve,&nbsp;Jaysing M. Dinore,&nbsp;Amol V. Sapkal,&nbsp;Ajeet A. Yelwande,&nbsp;Rajita D. Ingle","doi":"10.1134/S1070428024130165","DOIUrl":"10.1134/S1070428024130165","url":null,"abstract":"<p>A straightforward and efficient synthetic approach for creating polyhydroquinoline derivatives by the Hantzsch reaction using sulfanilic acid as a versatile and efficient catalyst has been proposed. These polyhydroquinoline derivatives are notable for their diverse forms of biological activity. The structures of the synthesized compounds were confirmed using spectroscopic techniques. This methodology provides several advantages, including high yields, cost-effectiveness, time efficiency, environmental friendliness, and operational simplicity.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S121 - S127"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Biological Activity, and Molecular Docking Study of New Triazoline Derivatives Using 2-Amino-5-p-subtituted Phenyl-1,3,4-thiadiazoles 2-氨基-5-对取代苯基-1,3,4-噻二唑类新型三唑啉衍生物的合成、生物活性及分子对接研究
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-01-11 DOI: 10.1134/S1070428024130104
Khadija Najah Zaidane, Ahmed Wahed Naser
{"title":"Synthesis, Biological Activity, and Molecular Docking Study of New Triazoline Derivatives Using 2-Amino-5-p-subtituted Phenyl-1,3,4-thiadiazoles","authors":"Khadija Najah Zaidane,&nbsp;Ahmed Wahed Naser","doi":"10.1134/S1070428024130104","DOIUrl":"10.1134/S1070428024130104","url":null,"abstract":"<p>In this study, new heterocyclic compounds containing 1,3,4-thiadiazole derivatives were synthesized. FT-IR, <sup>1</sup>H NMR, and <sup>13</sup>C NMR spectroscopy were used to identify the title compounds. In addition, some produced compounds were tested <i>in vitro</i> to assess their antimicrobial effectiveness against various microorganisms such as <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, demonstrating that some of these compounds exhibit very good antibacterial activity. Molecular docking of some of the synthesized compounds showed good results. 1,3,4-Thiadiazole derivatives (<b>1a</b>, <b>1b</b>) were prepared by a reaction of <i>p</i>-nitrobenzoic acid or <i>p</i>-toluic acid with thiosemicarbazide in the presence of POCl<sub>3</sub>. Alkylation of compounds <b>1a</b>,<b> 1b</b> with allyl bromide produced <i>N</i>-allyl thiadiazoles <b>2a</b>, <b>2b</b>. Cyclization of the prepared <i>p</i>-substituted azidobenzene and alkyl azides with compounds <b>2a</b>, <b>2b</b> resulted in the corresponding 1,4-disubstituted triazoline derivatives <b>3a</b>–<b>3h</b> and <b>4a</b>–<b>4d</b>. Molecular docking studies with the target 6ul7 indicated favorable docking scores and binding interactions for the newly synthesized compounds, highlighting their potential as effective antimicrobial agents.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"60 1 supplement","pages":"S70 - S77"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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