Russian Journal of Organic Chemistry最新文献_第5页

Synthesis and Antimicrobial Screening of 1-(Benzenesulfonyl)-3-chloro-4-haloaryl-4-methylazetidin-2-ones 1-（苯磺酰基）-3-氯-4-卤代芳基-4-甲基噻丁酮-2-酮的合成及抗菌筛选

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-11 DOI: 10.1134/S1070428025604212

M. Almehmdi, M. Asif

{"title":"Synthesis and Antimicrobial Screening of 1-(Benzenesulfonyl)-3-chloro-4-haloaryl-4-methylazetidin-2-ones","authors":"M. Almehmdi, M. Asif","doi":"10.1134/S1070428025604212","DOIUrl":"10.1134/S1070428025604212","url":null,"abstract":"A series of novel 1-(benzenesulfonyl)azetidin-2-one derivatives were synthesized and evaluated for their in vitro antimicrobial activity against a panel of bacterial and fungal strains. Halogen-substituted acetophenones were condensed with benzenesulfonamide to afford N-(1-haloarylethylidene)benzenesulfonamides 1a–1i. Staudinger cycloaddition of these imine intermediates with chloroacetyl chloride yielded the target 1-(benzenesulfonyl)-3-chloro-4-(haloaryl)-4-methylazetidin-2-ones 2a–2i. The structures of the synthesized compounds were fully elucidated using standard spectroscopic and analytical techniques. Antimicrobial screening via the agar disk diffusion method revealed that derivatives 2c, 2d, 2e, 2g, 2h, and 2i possess potent antibacterial activity, whereas compounds 2g, 2h, and 2i exhibit pronounced antifungal efficacy. The enhanced antimicrobial profiles were attributed to the specific electronic and steric configurations of the haloaryl substituents on the azetidinone scaffold, which are likely to optimize binding interactions with microbial cellular targets. Compounds 2g, 2h, and 2i represent promising lead candidates for the development of next-generation antibacterial and antifungal agents.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico and In Vitro Antibacterial Evaluation of Pyrazole Derivatives 吡唑衍生物的体外及硅内抗菌评价

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-11 DOI: 10.1134/S107042802560528X

A. Drioueche, H. Lettreuch, M. Khodja, Z. M. Boutaïba

{"title":"In Silico and In Vitro Antibacterial Evaluation of Pyrazole Derivatives","authors":"A. Drioueche, H. Lettreuch, M. Khodja, Z. M. Boutaïba","doi":"10.1134/S107042802560528X","DOIUrl":"10.1134/S107042802560528X","url":null,"abstract":"Building upon previous research on methylated pyrazole homologues, this study reports the synthesis of novel pyrazole derivative. The experimental and structural characteristics of alkyl 1-(2-aminophenyl)-5-hydroxy-1H-pyrazole-3-carboxylates were comprehensively investigated using FT-IR, 1H and 13C NMR, and mass spectrometry. Additionally, the in vitro antimicrobial activity of the resulting compounds was evaluated against a panel of bacterial and fungal strains. The experimental results demonstrated that several derivatives possess significant potency across most tested strains. The ADMET properties were also assessed, revealing that the synthesized compounds strictly adhere to Lipinski’s rule of five. Furthermore, molecular docking simulations were conducted against bacterial (PDB IDs: 3G75 and 6TTG) and fungal (PDB IDs: 4WMZ and 5ESE) protein targets to elucidate their underlying inhibitory mechanisms. These findings indicated that the obtained heterocycles possess favorable pharmacological attributes, including optimal lipophilicity, aqueous solubility, and robust pharmacokinetic profiles, thereby suggesting that these synthesized pyrazole derivatives hold significant potential as promising therapeutic candidates.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B(C6F5)3-Catalyzed Metal-Free Selective Reduction of α,β-Unsaturated Ketones with Pinacolborane B(C6F5)3催化蒎烷选择性还原α，β-不饱和酮

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-11 DOI: 10.1134/S1070428025604066

Zengfeng Zhang, Wenhui Cui, Lanning Liang, Wenhao Xue, Changgang Song, Hong Yu, Yang Cao

引用次数: 0

Synthesis, Characterization, and Anticancer Evaluation of New 2-Thioxo-4-imidazolidinone Derivatives against Human Breast Cancer Cells 新型2-硫氧基-4-咪唑烷酮衍生物的合成、表征及对人乳腺癌细胞的抗癌评价

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025605631

Tawfeeq K. Mahdi, Dakhil Z. Mutlaq

{"title":"Synthesis, Characterization, and Anticancer Evaluation of New 2-Thioxo-4-imidazolidinone Derivatives against Human Breast Cancer Cells","authors":"Tawfeeq K. Mahdi, Dakhil Z. Mutlaq","doi":"10.1134/S1070428025605631","DOIUrl":"10.1134/S1070428025605631","url":null,"abstract":"A novel series of nine 2-thioxo-4-imidazolidinone derivatives (K1B, K2A, P1A, P1B, P2A, P2B, P4A, P4B, and T5B) was synthesized through a multi-step sequence comprising maleimide functionalization, hydrazide formation, and subsequent cyclization with isothiocyanates. The chemical structures of the newly developed compounds were comprehensively elucidated using FT-IR, 1H, 13C NMR, and mass spectrometry (MS). The in vitro cytotoxicity of these derivatives was evaluated against human breast cancer cells (MDA-MB-231) utilizing the MTT assay and morphological variation analysis. Compounds P2A, P1A, P2B, P4A, and T5B exhibited promising antiproliferative activity, displaying IC50 values of 23.24, 38.87, 41.92, 42.26, and 49.82 µM, respectively. These findings highlight the 2-thioxo-4-imidazolidinone (thiohydantoin) framework as a viable and promising scaffold for anticancer drug discovery. Further investigations are warranted to clarify the underlying molecular mechanisms of action and establish comprehensive selectivity profiles.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Novel Schiff Nanocomposites and Evaluation of Their Biological Activity 新型希夫纳米复合材料的合成、表征及其生物活性评价

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025604807

Reem Suhail Najm, Qader Abdullah Shannak, Mohammed Jawhar Saleh, Jamil Nadhem Saleh, Aws Z. Abdulmajeed

{"title":"Synthesis and Characterization of Novel Schiff Nanocomposites and Evaluation of Their Biological Activity","authors":"Reem Suhail Najm, Qader Abdullah Shannak, Mohammed Jawhar Saleh, Jamil Nadhem Saleh, Aws Z. Abdulmajeed","doi":"10.1134/S1070428025604807","DOIUrl":"10.1134/S1070428025604807","url":null,"abstract":"The spread of multidrug-resistant bacterial strains (MDRB), a worldwide concern, has increased the mortality rates linked to bacterial and fungal infections in recent years, decreasing the efficacy of current treatments. Therefore, the development of novel antibacterial and antifungal agents is imperative. In this work, three Schiff base nanostructures (R1–R3) were synthesized via thermal fusion with triazole and various benzaldehyde derivatives. The prepared compounds were characterized using FT-IR, FESEM, XRD, AFM, and TGA/DSC. The results confirmed the successful formation of homogeneous nanostructures exhibiting high thermal stability. The nanoparticles’ morphological shape and crystalline characteristics were revealed by XRD and FESEM data. The agar diffusion method was used to assess the antibacterial activity of the produced nanoparticles against Staphylococcus aureus and Escherichia coli at concentrations of 0.01, 0.001, and 0.0001 mg/mL. The results indicated a concentration-dependent increase in antibacterial activity. Among the compounds tested, R1 showed the highest efficacy against both bacterial strains, demonstrating activity similar to that of the standard antibiotic ampicillin.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Mechanism of E–Z Isomerization of the Herbicide Clethodim: A Theoretical Approach 除草剂氯草酮E-Z异构化机理的理论探讨

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025605618

Javier G. Carreras, Danila L. Ruiz, Sergio L. Laurella

{"title":"On the Mechanism of E–Z Isomerization of the Herbicide Clethodim: A Theoretical Approach","authors":"Javier G. Carreras, Danila L. Ruiz, Sergio L. Laurella","doi":"10.1134/S1070428025605618","DOIUrl":"10.1134/S1070428025605618","url":null,"abstract":" Clethodim is a post-emergence systemic herbicide widely utilized for weed control in crops such as cotton, soy, and tobacco. Structurally, two recent studies have demonstrated that this compound exists in an equilibrium involving three major forms: E-ketoenolimine, Z-ketoenolimine, and E-diketoenamine. This work aims to establish and evaluate three rational pathways for the E–Z isomerization of clethodim, as a comprehensive understanding of this equilibrium is crucial for elucidating its mechanism of action and guiding the synthetic design of novel analogues. The proposed pathways comprise: (A) a direct, one-step isomerization; (B) a sequence of protonation, rotation, and deprotonation; and (C) a four-step cascade of tautomerization, rotation, deprotonation, and protonation. The activation energies for each pathway were quantified using density functional theory calculations at the B3LYP/6-31G(d,p) level. The four-step mechanism (C) exhibits the lowest activation barrier (140 kJ/mol vs 272 kJ/mol for pathway A and 251 kJ/mol for pathway B), which strongly correlates with previous experimental observations.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Humic Acid as a Recyclable Green Catalyst for the Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones in Water 腐植酸作为可循环绿色催化剂在水中合成2,3-二氢喹唑啉-4(1H)- 1

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025605503

Le Zhai, Bomin Zhang, Hongshe Wang

引用次数: 0

Theophylline Hydrogen Sulfate (THS): A Green, Efficient, and Reusable Catalyst for the Synthesis of 1,8-Dioxooctahydroxanthenes 硫酸氢茶碱（THS）：一种绿色、高效、可重复使用的1,8-二氧八羟基蒽合成催化剂

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025605564

Diksha B. Wahul, Ganesh B. Pund, Krishna R. Mandave, Sambhaji T. Dhumal, Tejshri R. Deshmukh, Prashant P. Mogle, Bhagwansing S. Dobhal, Madhav J. Hebade

引用次数: 0

Biological Evaluation of 1,2,3-Triazole-Modified 2H-1,4-Benzoxazin-3(4H)-one Derivatives as Dual Antitumor and Neuroprotective Agents 1,2,3-三唑修饰的2h -1,4-苯并恶嗪-3(4H)- 1衍生物作为双重抗肿瘤和神经保护剂的生物学评价

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025605515

Cheng Xiao-yi, Zhang Xiao, Huang Meng-meng, Jia Xiu-wen, Hou Xi-xi, Peng Lizeng

{"title":"Biological Evaluation of 1,2,3-Triazole-Modified 2H-1,4-Benzoxazin-3(4H)-one Derivatives as Dual Antitumor and Neuroprotective Agents","authors":"Cheng Xiao-yi, Zhang Xiao, Huang Meng-meng, Jia Xiu-wen, Hou Xi-xi, Peng Lizeng","doi":"10.1134/S1070428025605515","DOIUrl":"10.1134/S1070428025605515","url":null,"abstract":"Malignant tumors are frequently accompanied by neurological damage or neuroinflammation, severely compromising patient outcomes. Consequently, the development of multitarget small molecules possessing concurrent anticancer and neuroprotective properties is of paramount importance. Capitalizing on the pharmacological relevance of the 2H-1,4-benzoxazin-3(4H)-one scaffold and the structural versatility of 1,2,3-triazoles, fifteen novel benzoxazinone–triazole hybrids were designed and synthesized via terminal alkyne functionalization and subsequent click chemistry. Their antitumor efficacy against lymphoma cell lines and their neuroprotective effects were systematically evaluated. Most hybrids exhibited pronounced antiproliferative activity against Ramos and REC-1 cells, with compound 11n emerging as the most potent derivative, displaying an IC50 value of 3.03 μM against Ramos cells. Furthermore, compound 11n afforded robust protection against glutamate-induced injury in HT22 cells, significantly restoring cell viability to 48.74% at 10 μM, thereby outperforming the reference drug resveratrol. Collectively, these findings demonstrate that compound 11n features a compelling dual-action profile, representing a promising multitarget lead compound for further therapeutic optimization.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploiting the Triazole–Urea Hybrid as a Privileged Scaffold for Novel Anti-HCC Agents: Discovery of a Potent Inducer of DNA Damage and Apoptosis 利用三唑-尿素杂合物作为新型抗hcc药物的特殊支架：发现一种有效的DNA损伤和细胞凋亡诱导剂

IF 0.8 4区化学

Russian Journal of Organic Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070428025605370

En Gao, Wanli Zhang, Haoying Zhang, Yajie Guo, Jinting Ma, Zixin Wang, Ningning Shi, Lida Shangguan, Shouhu Li

引用次数: 0