Prostaglandins and medicine最新文献_第3页

Comparative studies on the hemodynamic effects of prostaglandin E1 prostacyclin, and tolazoline upon elevated pulmonary vascular resistance in neonatal swine 前列腺素E1、前列环素和托唑啉对新生猪肺血管阻力升高影响的比较研究

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90024-0

M.B. Starling , J.M. Neutze , R.L. Elliott , R.B. Elliott

{"title":"Comparative studies on the hemodynamic effects of prostaglandin E1 prostacyclin, and tolazoline upon elevated pulmonary vascular resistance in neonatal swine","authors":"M.B. Starling , J.M. Neutze , R.L. Elliott , R.B. Elliott","doi":"10.1016/0161-4630(81)90024-0","DOIUrl":"10.1016/0161-4630(81)90024-0","url":null,"abstract":"<div>Forty-eight hour old anesthetised and ventilated neonatal piglets were cannulated in order to measure pressures, blood gases and cardiac outputs (CO) from which pulmonary (PVR) and systemic (SVR) vascular resistances were calculated. After baseline measurements had been made inspired gases were altered to produce hypoxemia and hypercapnia, to raise PVR. Animals then received Prostaglandin E1 (PGE1), Tolazoline (TOL), and Prostacyclin (PGI2) in varying dosages until PVR was reduced or the dosage no longer tolerated.With “hypoxia” CO, PVR and pulmonary artery (PA) pressures rose; aortic pressure also rose although SVR tended to fall. PGE1 (5μg/kg/min) and PGI2 (1.0 μg/kg/min) both produced a significant fall in PVR. The decrease in PVR with TOL (1 mg/kg/10 minutes and 2 mg/kg/l hour) was less consistent and in surviving animals did not achieve statistical significance by multivariate analysis. SVR fell with all drugs although the change with TOL was again non-significant. With both PGI2 and TOL there was a trend for CO to rise and, although this did not reach significant levels, it restricted the drop in arterial pressure to approximately control levels. The fall in arterial pressure with PGE1 was greater. The death rate with treatment with TOL was much higher than that seen with the other two drugs.Circulatory changes in a group of animals with normal blood gases treated with PGI2 (1 μg/kg/min) were similar to those seen with the hypoxic group.In this preparation PGI2 appeared the most satisfactory drug for the treatment of elevated PVR.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 349-361"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90024-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18081701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Monthly bibliography on prostaglandins prepared by the University of Sheffield biomedical information service 谢菲尔德大学生物医学信息服务处编写的前列腺素月度参考书目

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90035-5

引用次数: 0

The effects of arachidonic acid on aqueous humor dynamics of the isolated arterially perfused cat eye 花生四烯酸对离体动脉灌注猫眼房水动力学的影响

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90029-X

G.W.H.M. van Alphen , Frank J. Macri

引用次数: 2

Is PGI2 arrhythmogenic? investigations on ouabain induced arrhythmias in cats PGI2是否致心律失常?乌巴因致猫心律失常的研究

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90030-6

H.-J. Meet, W. Förster

引用次数: 10

Effect of PGE1, PGE2 and PGI2 on ventricular arrhythmias during myocardial infarction in conscious dogs: Relation to infarct size 清醒犬心肌梗死时PGE1、PGE2和PGI2对室性心律失常的影响:与梗死面积的关系

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90032-X

Bodh I. Jugdutt

{"title":"Effect of PGE1, PGE2 and PGI2 on ventricular arrhythmias during myocardial infarction in conscious dogs: Relation to infarct size","authors":"Bodh I. Jugdutt","doi":"10.1016/0161-4630(81)90032-X","DOIUrl":"10.1016/0161-4630(81)90032-X","url":null,"abstract":"<div>The relation between the effect of vasodilator prostaglandins on ventricular arrhythmias during myocardial infarction and infarct size was studied in conscious dogs. Two infarct-limiting drugs, nitroglycerin and ibuprofen, were also studied for comparison. Infusions were given between 20 and 380 minutes after occlusion of the left circumflex coronary artery: intravenously for saline (N = 27), ibuprofen (N = 14), and nitroglycerin (N = 14); left atrially for PGE1 (N = 11), PGE2 (N = 12) and PGI2 (N = 18). Doses of prostaglandins and nitroglycerin were adjusted to decrease mean arterial pressure by 5%. Pathologic infarct size was measured 2 days post-occlusion. During the infusion period, ventricular fibrillation (VF) deaths were nil with PGI2 (p < 0.05) and nitroglycerin (p < 0.1), ventricular premature beats (VPB's) were less (p < 0.01) with PGI2, PGE2 and nitroglycerin, and collateral blood flow (microspheres) increased with PGE1, PGI2 and nitroglycerin but did not change with saline, PGE and ibuprofen. Infarct size, as percent of left ventricle or occluded bed, was less (p < 0.05) with PGE1, PGI2, nitroglycerin and ibuprofen but similar with PGE2 and saline. Thus, PGE2 diminished VPB's despite no effect on flow or infarct size. In contrast, both PGE1 and PGI2 diminished VPB's, increased flow and decreased infarct size, but PGI2 also reduced VF mortality.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 431-455"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90032-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17851710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Plasma 6 keto PGF1α concentration in Raynaud's phenomenon 血浆6酮PGF1α浓度与雷诺现象的关系

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90027-6

Evlin L. Kinney, Laurence M. Demers

{"title":"Plasma 6 keto PGF1α concentration in Raynaud's phenomenon","authors":"Evlin L. Kinney, Laurence M. Demers","doi":"10.1016/0161-4630(81)90027-6","DOIUrl":"10.1016/0161-4630(81)90027-6","url":null,"abstract":"<div>To examine the possibility that prostaglandin metabolism is pathophysiologically important in Raynaud's phenomenon, peripheral venous 6-keto prostaglandin Fla (6-keto PGF1α) and thromboxane B2 (TXB2) concentrations were measured in 45 patients with severe Raynaud's phenomenon. Patients with Raynaud's phenomenon had a significantly higher plasma concentration of 6-keto PGF1α compared to controls (p < .001), although their plasma TXB2 concentration was not statistically different from control patients. Subgroup analysis revealed that only patients with progressive systemic sclerosis (PSS) had an elevated plasma 6-keto PGF1α concentration. To gauge the functional significance of the 6-keto PGF1α elevations, seven patients with Raynaud's phenomenon were chronically administered indomethacin (50 mg P.O. b.i.d.); six of the seven patients noted no improvement in their Raynaud's phenomenon. Three of the patients developed pedal edema shortly after starting indomethacin. This study suggests that the increased plasma 6-keto PGF1α concentration in Raynaud's phenomenon may be due to a compensatory release of prostacyclin and that the pathophysiologic defect does not involve the thromboxane mechanism.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 389-393"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90027-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17945306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The effect of vasopressin in water-loaded hypokalemic patients is prostaglandin-independent 抗利尿激素在水负荷低钾患者中的作用与前列腺素无关

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90034-3

Jose A. Rodriguez, Catherine S. Delea, Frederic C. Bartter, Helmy Siragy

{"title":"The effect of vasopressin in water-loaded hypokalemic patients is prostaglandin-independent","authors":"Jose A. Rodriguez, Catherine S. Delea, Frederic C. Bartter, Helmy Siragy","doi":"10.1016/0161-4630(81)90034-3","DOIUrl":"10.1016/0161-4630(81)90034-3","url":null,"abstract":"<div>Potassium-depleted subjects regularly excrete dilute urine with a high free-water clearance which cannot be suppressed either by solute loading or by water deprivation. In man, as in the dog and rat, potassium depletion impairs the ability of the kidney to achieve maximal urinary solute concentration and vasopressin is unsuccessful in overcoming this defect. In man and in the dog, potassium depletion induces a rise in urinary prostaglandin E2, an effect which can be reversed with indomethacin, a cyclo-oxygenase inhibitor. To evaluate the role of prostaglandins on the renal action of vasopressin in hypokalemia, six subjects with hypokalemia of various etiologies were studied in a control, drug-free condition and again after 3 to 6 days of indomethacin (100 mg/day). Renal clearance studies to measure the maximal free-water excretion in response to an intravenous water load (10 ml/min) and to a superimposed infusion of arginine vasopressin (40 mU/hr) were performed. The results in six patients are as follows: maximal free-water clearance (control) 8.03 ± 0.8 ml/min (mean ± S.E.), with the addition of vasopressin, .14 ± 0.8; after 3 to 6 days of indomethacin, 8.55 ± 1.33; with vasopressin 0.91 ± 1.23 ml/min. There was no statistically significant difference between the maximal free water clearance with or without indomethacin. Vasopressin exerted an equally great response in both conditions and prostaglandins did not appear to play a role in free-water formation.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 465-472"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90034-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18335734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prostacyclin effect on blood pressure in pig with aortic obstruction 前列环素对猪主动脉阻塞血压的影响

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90133-6

M.O. Triulzi , M.G. Clement, A. Celsi , G. Aguggini

引用次数: 1

Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles 白三烯A4、B4、C4和D4对豚鼠、大鼠、家兔和人平滑肌的药理活性

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90137-3

P. Sirois , S. Roy , J.P. Tétrault , P. Borgeat , S. Picard , E.J. Corey

引用次数: 90

The role of prostaglandins in the development of malignant melanoma in hamsters 前列腺素在仓鼠恶性黑色素瘤发展中的作用

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90136-1

Cezar M. Popescu

引用次数: 4