Prostaglandins and medicine最新文献_第4页

Spironolactone inhibits vascular reactivity by a prostaglandin-related mechanism unconnected with aldosterone 螺内酯通过与醛固酮无关的前列腺素相关机制抑制血管反应性

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90135-X

M. Oka, M.S. Manku

引用次数: 6

Effect of antihypertensive drugs on plasma benin activity and urinary excretion of prostaglandin E2 降压药对血浆benin活性及尿前列腺素E2排泄的影响

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90131-2

M. Blum, A. Algueti, S. Bauminger, A. Aviram, D. Ayalon

引用次数: 2

Interactions between dopamine and prostaglandins on vascular reactivity to noradrenaline: Dopamine inhibits the action of PGE1 多巴胺和前列腺素对血管去甲肾上腺素反应的相互作用:多巴胺抑制PGE1的作用

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90132-4

M. Oka, M.S. Manku, D.F. Horrobin

{"title":"Interactions between dopamine and prostaglandins on vascular reactivity to noradrenaline: Dopamine inhibits the action of PGE1","authors":"M. Oka, M.S. Manku, D.F. Horrobin","doi":"10.1016/0161-4630(81)90132-4","DOIUrl":"10.1016/0161-4630(81)90132-4","url":null,"abstract":"<div>Interactions between dopamine and responses to noradrenaline as modulated by prostaglandins (PGs) were studied in the perfused rat mesenteric vascular bed. When perfused alone dopamine up to a concentration of 10−7M neither changed baseline pressure nor modified the pressor response to noradrenaline. Dopamine at 10−9 to 10−7M significantly inhibited responses to noradrenaline which had been enhanced by the presence of 10−10 to 10−8 M PGEI. In preparations in which vascular responses to noradrenaline had been abolised by indomethacin and restored by adding PGEI, 10−9 to 1−7M dopamine significantly inhibited the restored responses. Dopamine also attenuated the inhibitory effects of prostacyclin on pressor responses to noradrenaline but it did not change the actions of either PGE2 or PGF2 alpha. Pimozide, a mainly centrally acting dopamine antagonist, did not interfere with these peripheral actions of dopamine. The dopamine effects were blocked by another dopamine antagonist, metoclopramide. Dopamine can inhibit the effects of PGEI and prostacyclin in the rat mesenteric vascular bed, possibly by interacting with specific dopamine receptors.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 4","pages":"Pages 267-280"},"PeriodicalIF":0.0,"publicationDate":"1981-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90132-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17997316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of PGI2 on pattern of breathing in the pig during aortic obstruction PGI2对猪主动脉阻塞时呼吸模式的影响

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90134-8

M.G. Clement, M.O. Triulzi , A. Celsi , G. Aguggini

引用次数: 1

Monthly bibliography on prostaglandins prepared by the University of Sheffield biomedical information service 谢菲尔德大学生物医学信息服务处编写的前列腺素月度参考书目

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90139-7

引用次数: 0

Refractoriness of diabetic platelets to inhibitory prostaglandins 糖尿病血小板对抑制性前列腺素的难治性

Prostaglandins and medicine Pub Date : 1981-10-01 DOI: 10.1016/0161-4630(81)90138-5

M. Lagarde, P. Berciaud, M. Burtin, M. Dechavanne

引用次数: 21

In vitro plateletutilization of (1-14C) arachidonic acid in normal humans of different age and sex and in acute myocardial infarction patients: A Comparative study for possible diagnostic purposes (1-14C)花生四烯酸在不同年龄和性别的正常人和急性心肌梗死患者的体外血小板利用:一项可能诊断目的的比较研究

Prostaglandins and medicine Pub Date : 1981-09-01 DOI: 10.1016/0161-4630(81)90102-6

K.C. Srivastava, K.P. Tiwari

{"title":"In vitro plateletutilization of (1-14C) arachidonic acid in normal humans of different age and sex and in acute myocardial infarction patients: A Comparative study for possible diagnostic purposes","authors":"K.C. Srivastava, K.P. Tiwari","doi":"10.1016/0161-4630(81)90102-6","DOIUrl":"10.1016/0161-4630(81)90102-6","url":null,"abstract":"<div>Age and sex related platelet biosynthesis of prostaglandins, thromboxane B2, prostaglandin endoperoxides, HHT and HETE was studied in normal human subjects and in acute myocardial infarction (AMI) patients (all males over 50 yr). The following results were obtained. 1. No significant difference was observed in the platelet biosynthesis of prostaglandins (F2α, E2, D2 ), TxB2 and HHT in normal subjects when values of these arachidonic acid metabolites were compared for different age groups and sex. 2. HETE formation in females was significantly more (p < 0.001) than that in males. 3. No significant difference was observed in the prostaglandin endoperoxide level (PGG2, PGH2 + PGF2α) amongst different age groups and sex in the normal subjects and this was so when compared with AMI patients. 4. Significantly less TxB2 was produced by platelets from the AMI patients compared to normal males over 50 years. 5. In AMI patients, platelets produced significantly more HHT (p < 0.005) and PGF2α (p < 0.02) compared to normal males over 50 years. 6. A significantly reduced (p < 0.005) formation of HETE in the AMI patients compared to normal males (over 50 yr) was observed. A comparison of ratios between HHT, HETE and TxB2 for normal males (over 50 yr) and AMI patients was made for their possible use in diagnostic purposes.These results have been discussed in the light of the existing knowledge about the aggregation and antiaggregation properties of various AA metabolites.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 3","pages":"Pages 229-243"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90102-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17847420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Monthly bibliography on prostaglandins Prepared by the University of Sheffield biomedical information service 由谢菲尔德大学生物医学信息服务处编写的前列腺素月度参考书目

Prostaglandins and medicine Pub Date : 1981-09-01 DOI: 10.1016/0161-4630(81)90105-1

引用次数: 0

Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease 高血压或脑血管疾病患者血凝素B2浓度变化

Prostaglandins and medicine Pub Date : 1981-09-01 DOI: 10.1016/0161-4630(81)90099-9

Osamu Uyama, Masayasu Matsumoto, Atsushi Fujisawa, Masahito Kusunoki, Shotaro Yoneda, Masatoshi Imaizumi, Kazufumi Kimura, Hiroshi Abe

{"title":"Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease","authors":"Osamu Uyama, Masayasu Matsumoto, Atsushi Fujisawa, Masahito Kusunoki, Shotaro Yoneda, Masatoshi Imaizumi, Kazufumi Kimura, Hiroshi Abe","doi":"10.1016/0161-4630(81)90099-9","DOIUrl":"10.1016/0161-4630(81)90099-9","url":null,"abstract":"<div>The peripheral venous plasma levels of thromboxane B2 (TxB2) were determined by radioimmunoassay in 22 control subjects, 12 patients with essential hypertension, 15 patients with cerebrovascular disease (CVD) not taking aspirin and 14 patients with CVD taking aspirin. There was no significant difference in TxB2 levels among the control subjects, hypertensive patients and CVD patients not taking aspirin. In CVD patients taking aspirin, the plasma TxB2 levels were significantly lower than those in the other groups. The internal jugular venous concentrations of TxB2 were measured in 10 CVD patients not taking aspirin. Four of 10 studied patients exhibited significant increases only in the internal jugular venous TxB2 levels, while peripheral venous and/or femoral arterial TxB2 levels were not significantly different from peripheral venous TxB2 levels of control subjects.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 3","pages":"Pages 199-207"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90099-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18316040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Release of prostaglandins E2, I2, and D2 from perfused rabbit vascular tissue stimulated by ricinoleic acid 蓖麻油酸刺激灌注兔血管组织释放前列腺素E2、I2和D2

Prostaglandins and medicine Pub Date : 1981-09-01 DOI: 10.1016/0161-4630(81)90100-2

H. Juan

{"title":"Release of prostaglandins E2, I2, and D2 from perfused rabbit vascular tissue stimulated by ricinoleic acid","authors":"H. Juan","doi":"10.1016/0161-4630(81)90100-2","DOIUrl":"10.1016/0161-4630(81)90100-2","url":null,"abstract":"<div>The prelabelling technique (incorporation of (1-14C)-arachidonic acid was used to investigate the influence of ricinoleic acid on prostaglandin biosynthesis in peripheral vessels. Infusion of ricinoleic acid (0.2 mM) intra-arterially into the isolated perfused ear stimulated the release of labelled arachidonic acid and metabolites. The major metabolite released was PGE2 followed by PGI2 (measured as 6-keto-PGF1α ) and PGD2 Prostaglandin release was abolished by indometacin (3 μg/ml) and strongly reduced by perfusion with calcium-free, 1 mM EGTA containing solution. In the presence of bovine serum albumin there was a basal release of high amounts of arachidonic acid. Ricinoleic acid tended to increase the released amount of labelled arachidonic acid. In contrast to indometacin, perfusion with calcium-free, 1 mM EGTA containing solution tended to reduce the release of arachidonic acid. The results show that in the peripheral vascular bed ricinoleic acid stimulates the release of arachidonic acid and metabolites probably by activating a calcium-dependent phospholipase A2. Since ricinoleic acid is well absorbed from the gut, such an effect may occur after ingestion of a highly laxative dose.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 3","pages":"Pages 209-215"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90100-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18076619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6