M. Blum, A. Algueti, S. Bauminger, A. Aviram, D. Ayalon
{"title":"降压药对血浆benin活性及尿前列腺素E2排泄的影响","authors":"M. Blum, A. Algueti, S. Bauminger, A. Aviram, D. Ayalon","doi":"10.1016/0161-4630(81)90131-2","DOIUrl":null,"url":null,"abstract":"<div><p>Urinary prostaglandin (PGE<sub>2</sub>) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment withdifferent antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE<sub>2</sub> and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters.</p><p>In view of these findings it seems therefore as if renal production of PGE<sub>2</sub> (at least with regard to propranolol, a β-blocking agent), is not related to the hypotensive effect of the drug.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 4","pages":"Pages 261-266"},"PeriodicalIF":0.0000,"publicationDate":"1981-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90131-2","citationCount":"2","resultStr":"{\"title\":\"Effect of antihypertensive drugs on plasma benin activity and urinary excretion of prostaglandin E2\",\"authors\":\"M. Blum, A. Algueti, S. Bauminger, A. Aviram, D. Ayalon\",\"doi\":\"10.1016/0161-4630(81)90131-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Urinary prostaglandin (PGE<sub>2</sub>) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment withdifferent antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE<sub>2</sub> and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters.</p><p>In view of these findings it seems therefore as if renal production of PGE<sub>2</sub> (at least with regard to propranolol, a β-blocking agent), is not related to the hypotensive effect of the drug.</p></div>\",\"PeriodicalId\":76381,\"journal\":{\"name\":\"Prostaglandins and medicine\",\"volume\":\"7 4\",\"pages\":\"Pages 261-266\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-4630(81)90131-2\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161463081901312\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161463081901312","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of antihypertensive drugs on plasma benin activity and urinary excretion of prostaglandin E2
Urinary prostaglandin (PGE2) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment withdifferent antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE2 and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters.
In view of these findings it seems therefore as if renal production of PGE2 (at least with regard to propranolol, a β-blocking agent), is not related to the hypotensive effect of the drug.
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