M. Blum, A. Algueti, S. Bauminger, A. Aviram, D. Ayalon
{"title":"Effect of antihypertensive drugs on plasma benin activity and urinary excretion of prostaglandin E2","authors":"M. Blum, A. Algueti, S. Bauminger, A. Aviram, D. Ayalon","doi":"10.1016/0161-4630(81)90131-2","DOIUrl":null,"url":null,"abstract":"<div><p>Urinary prostaglandin (PGE<sub>2</sub>) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment withdifferent antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE<sub>2</sub> and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters.</p><p>In view of these findings it seems therefore as if renal production of PGE<sub>2</sub> (at least with regard to propranolol, a β-blocking agent), is not related to the hypotensive effect of the drug.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 4","pages":"Pages 261-266"},"PeriodicalIF":0.0000,"publicationDate":"1981-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90131-2","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161463081901312","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Urinary prostaglandin (PGE2) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment withdifferent antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE2 and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters.
In view of these findings it seems therefore as if renal production of PGE2 (at least with regard to propranolol, a β-blocking agent), is not related to the hypotensive effect of the drug.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
