Prostaglandins and medicine最新文献_第2页

Response of the soft tissue microcirculation to prostacyclin infusion 前列环素输注对软组织微循环的影响

Prostaglandins and medicine Pub Date : 1981-12-01 DOI: 10.1016/0161-4630(81)90038-0

Robert H. Demling, Robert Gunther

{"title":"Response of the soft tissue microcirculation to prostacyclin infusion","authors":"Robert H. Demling, Robert Gunther","doi":"10.1016/0161-4630(81)90038-0","DOIUrl":"10.1016/0161-4630(81)90038-0","url":null,"abstract":"<div>We studied the effect of prostacyclin infusion on the soft tissue microcirculation. We used lymph flow QL and the lymph/plasma L/P protein ratio to reflect transvascular fluid flux and changes in microvescular hydrostatic pressure, Pmv.Unanesthetized sheep with prefemoral lymph fistulae were infused with PGI2 (0.2 ug/kg/min) for two hours. Changes in QL and L/P were compared to animals in which Pmv was increased by volume loading. During PGI2, QL was significantly increased, as was cardiac output while mean aortic pressure decreased. The UP ratio did not decrease to the degree seen with a comparable increase in QL, due to an increase in Pmv. The increase in QL was most likely due to an increase in microvescular surface area. QL remained significantly increased for several hours after infusion and L/P decreased to the same degree as seen with an increase in Pmv. This indicates that Pmv is increased for several hours in soft tissue after PGI2 infusion, due to a relative increase in venous resistance probably secondary to activation of the renin-angiotensin system.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 6","pages":"Pages 489-498"},"PeriodicalIF":0.0,"publicationDate":"1981-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90038-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18081585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Platelets of spontaneously hypertensive rats are not abnormally sensitive to PGI2 自发性高血压大鼠血小板对PGI2无异常敏感性

Prostaglandins and medicine Pub Date : 1981-12-01 DOI: 10.1016/0161-4630(81)90039-2

J.H. Botha, W.P. Leary

引用次数: 3

Effects of acute paraquat toxicity on circulating levels of arachidonic acid, PGF2α and PGE2 in the beagle 急性百草枯毒性对小猎犬体内花生四烯酸、PGF2α和PGE2循环水平的影响

Prostaglandins and medicine Pub Date : 1981-12-01 DOI: 10.1016/0161-4630(81)90047-1

David B. Chandler, Shri N. Giri

{"title":"Effects of acute paraquat toxicity on circulating levels of arachidonic acid, PGF2α and PGE2 in the beagle","authors":"David B. Chandler, Shri N. Giri","doi":"10.1016/0161-4630(81)90047-1","DOIUrl":"10.1016/0161-4630(81)90047-1","url":null,"abstract":"<div>We studied the effects of paraquat (25 mg/kg, free base, I.V.) on the circulating plasma levels of arachidonic acid, PGF2a and PGE2 in the beagle. The arachidonic acid level was quantified by GLC and prostaglandins by radioim unoassay.The plasma levels of arachidonic acid after paraquat treatment were decreased to 50.8% of control at 0.5 hrs. Thereafter the levels increased with time reaching a maximum level of 127.8% at 12 hrs, from which it decreased to 82.8% of control at 24 hrs. Concurrent with these changes in arachidonic acid, the plasma PGE2 levels at 0.5, 1.5, 6.0, 12.0 and 24.0 hrs were significantly decreased to 65.4%, 42.5%, 52.4%, 41.0% and 50.3% of control levels, respectively. In contrast to these findings the plasma levels of PGF2a after paraquat treatment were insignificantly elevated at 0.5, 3.0, 6.0, 12.0, and 24.0 hrs, to 174.3%, 170.4%, 119.3%, 183.3% and 180.3% of control respectively. The ratio of PGE2/PGF2α exhibited a significant decrease at 12.0 and 24.0 hrs. Histopathological studies revealed insignificant changes of the lungs, but marked changes of the kidney. We concluded from these studies that changes in plasma levels of prostaglandins may be related to the acute nephrotoxicity caused by paraquat in dogs.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 6","pages":"Pages 571-579"},"PeriodicalIF":0.0,"publicationDate":"1981-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90047-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17850698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dissociation of vascular resistance with endocrine pancreas secretion: The effects of epoxymethano analogs of PGH2 血管阻力与内分泌胰腺分泌的分离:PGH2环氧甲烷类似物的影响

Prostaglandins and medicine Pub Date : 1981-12-01 DOI: 10.1016/0161-4630(81)90036-7

J.O. Akpan , M.C. Hurley , S. Pek , W.E.M. Lands

引用次数: 2

Prostacyclin effect on cardiovascular system in man evaluated by echocardiography 超声心动图评价前列环素对人心血管系统的影响

Prostaglandins and medicine Pub Date : 1981-12-01 DOI: 10.1016/0161-4630(81)90040-9

M.O. Triulzi, D. Cirino, F. Gentile, G. Balice, G. Aguggini , G.C. Maggi

{"title":"Prostacyclin effect on cardiovascular system in man evaluated by echocardiography","authors":"M.O. Triulzi, D. Cirino, F. Gentile, G. Balice, G. Aguggini , G.C. Maggi","doi":"10.1016/0161-4630(81)90040-9","DOIUrl":"10.1016/0161-4630(81)90040-9","url":null,"abstract":"<div>This was an echocardiographic study of the cardiovascular effects of rostacclin (PGI2) infused intravenously to human volunteers at the rate of 20 ng⊎ Kg− ⊎ min− for 10 Anutes. The following parameters were recorded in the steady state , at one-minute intervals throughout infusion and the ensuing recovery period: systolic, diastolic, and mean blood pressure ( SBP, DBP, MBP); heart rate (HR); left ventricle end-diastolic (EDD) and end-systolic diameter (ESD); stroke volume index ( SVI); cardiac index (CI); peripheral vascular resistance (PVR); left ventricle fractional shortening (FS) and ejection fraction (EF).We detected a progressive reduction of MBP without any HR modification. MBP reduction was associated with a reduction of PVR and a parallel rise of CI and SVI. There was also an increase of FS and EF reflecting a reduced ESD. We conclude that PGI2 infused in man at the rate stated above causes hypotension reflecting an arterial vasodilating effect; a lack of heart rate reflex response to afterload reduction (probably a nerve-mediated effect of PGI ); and no venous vasodilation, judging from the absence of any change in end-diastolic diameter.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 6","pages":"Pages 501-510"},"PeriodicalIF":0.0,"publicationDate":"1981-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90040-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18081587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In vivo effects of leukotriene B4, C4 and D4. Evidence that changes in blood pressure are mediated by prostaglandins 白三烯B4、C4和D4的体内效应。有证据表明血压的变化是由前列腺素介导的

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90025-2

P. Sirois , R. Kérouac , S. Roy , P. Borgeat , S. Picard , F. Rioux

{"title":"In vivo effects of leukotriene B4, C4 and D4. Evidence that changes in blood pressure are mediated by prostaglandins","authors":"P. Sirois , R. Kérouac , S. Roy , P. Borgeat , S. Picard , F. Rioux","doi":"10.1016/0161-4630(81)90025-2","DOIUrl":"10.1016/0161-4630(81)90025-2","url":null,"abstract":"<div>Intra-jugular nanomole injections of leukotrienes B4, C4 and D4 (LTB4, LTC4, LTD4) in anesthetized guinea-pigs have been shown to cause dose-dependent increases of the mean arterial blood pressure. While the responses to LTB4 were monophasic, the responses to LTC4 and LTD4 were characterized by a fast (10–50 sec), medium high, first pressor phase followed by a second, longer lasting (3–9 min), more important pressor phase. Like antigen-antibody reactions, leukotrienes induced cardiac effects such as tachycardia and rhythm disturbances as well as respiratory difficulties, convulsions and sometimes death of the animals. The prostaglandin synthesis inhibitor, indomethacin, reduced the pressor response and the tachyarrhythmic effects of LTB4, C4 and D4. These results raise the possibility that leukotrienes produce their hemodynamic effects in guinea-pigs by stimulating the synthesis and release of biologically active derivatives of arachidonic acid.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 363-373"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90025-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17338237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Lithium stimulates thrombosane B2 formation in human platelets 锂刺激血小板形成凝血酶B2

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90031-8

Leon Imandt, Dorien Tijhuis, Hans Wessels, Clemens Haanen, Rob van den Berg, Chris Thomas

引用次数: 7

Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus? 缺氧是否选择性刺激离体大鼠子宫产生前列腺素E1 ?

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90026-4

M.F. Gimeno , M. Chaud , E.S. Borda , M. Lazzari , A.L. Gimeno

{"title":"Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus?","authors":"M.F. Gimeno , M. Chaud , E.S. Borda , M. Lazzari , A.L. Gimeno","doi":"10.1016/0161-4630(81)90026-4","DOIUrl":"10.1016/0161-4630(81)90026-4","url":null,"abstract":"<div>The contractile activity of uterine horns maintained for 90 to 120 minutes under normal oxygenation (carbogen or 100% O2) became undetectable. When in this condition the gassing was stopped one or two minutes later, regular phasic contractions appeared super-imposed on a small increment of the basal resting tone. Indomethacin and aspirin well known inhibitors of prostaglandin (PG) synthesis, blocked the contractile influence of hypoxia whereas neither tranylcypromine or imidazole were able to alter the stimulatery action. PGE2, PGE1 and PGF2α released into the bathing solution during 10 minutes of normoxia or 10 minutes of hypoxia, were measured. Under O2, PGE2 and PGF2α production diminished significantly (P < 0.05 and P < 0.01, normoxia vs. hypoxia, respectively) whereas PGE1 increased (P < 0.05). “PGI2-like material” generated was also detected and it was found that the values during hypoxia were lower than those observed in 02; however the difference was not statistically significant. Dose-response contractile activity to PGs with and without gassing was explored. It was necessary to add 100 times more PGF2α to obtain the minimal response under hypoxic conditions as compared to normoxia. On the other hand the threshold response to PGE1 was 10 times lower under hypoxic conditions than in normoxia. The possible mechsnism(s) that induce an increment in PGE1 generation accompanied by a simultaneous decrement of PGE2 during hypoxia is discussed in connection with a possible role of PGE1 evoking uterine contractions when the gassing of the suspending solution is stopped.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 375-388"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90026-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17996943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Effects of prostaglandin inhibition on renal function in deoxycorticosterone-acetate hypertensive Yucatan miniature swine 前列腺素抑制对脱氧皮质酮-醋酸盐高血压尤卡坦小型猪肾功能的影响

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90028-8

Charles D. Ciccone, Edward J. Zambraski

{"title":"Effects of prostaglandin inhibition on renal function in deoxycorticosterone-acetate hypertensive Yucatan miniature swine","authors":"Charles D. Ciccone, Edward J. Zambraski","doi":"10.1016/0161-4630(81)90028-8","DOIUrl":"10.1016/0161-4630(81)90028-8","url":null,"abstract":"<div>This study evaluated the effect of prostaglandin (PG) on renal function in normal and deoxycorticosterone-acetate (DOCA) hypertensive Yucatan miniature swine. Eight animals were implanted with DOCA impregnated silicone strips. MAP increased in the conscious DOCA animals from a normal pressure of 110–115 mmHg, to 148 ± 4 mmHg.After 3–4 weeks, the DOCA hypertensive and eight normal (sham or non-implanted) animals were anesthetized with sodium pentobarbital which reduced MAP in the DOCA pigs to normotensive levels. Under anesthesia, PG inhibition (indomethacin or meclofenamate, 2 mg/kg i.v.) increased MAP only in the normal group (P < .05). PG inhibition caused a significant reduction in renal blood flow in both groups, but only decreased glomerular filtration rate in the DOCA animals (P < .05). Radioactive microsphere distribution to the outer cortex of the normal animals was significantly decreased with PG inhibition, (P < .05). No consistant changes in electrolyte excretion or urine flow rate was seen in either group following PG inhibition. These data indicate that PG may influence renal hemodynamics in both normal and DOCA hypertensive Yucatan miniature swine. The finding that PG inhibition selectively decreases GFR in the DOCA animals suggests a possible protective role of these hormones in this hypertensive animal model.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 5","pages":"Pages 395-402"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90028-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18335733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats 甘草酸通过激活大鼠腹腔巨噬细胞抑制前列腺素E2的产生

Prostaglandins and medicine Pub Date : 1981-11-01 DOI: 10.1016/0161-4630(81)90033-1

Kazuo Ohuchi , Yuko Kamada , Lawrence Levine , Susumu Tsurufuji

引用次数: 105