P. Sirois , S. Roy , J.P. Tétrault , P. Borgeat , S. Picard , E.J. Corey
{"title":"白三烯A4、B4、C4和D4对豚鼠、大鼠、家兔和人平滑肌的药理活性","authors":"P. Sirois , S. Roy , J.P. Tétrault , P. Borgeat , S. Picard , E.J. Corey","doi":"10.1016/0161-4630(81)90137-3","DOIUrl":null,"url":null,"abstract":"<div><p>The myotropic activity of leukotrienes A <sub>4</sub>, B<sub>4</sub>, C<sub>4</sub>, D<sub>4</sub> and histamine has been evaluated on selected smooth muscle preparations. LTA<sub>4</sub>, B<sub>4</sub>, C<sub>4</sub> and D<sub>4</sub> were several times more potent than histamine on the guinea-pig lung parenchymal strip, while on the guinea-pig trachea, LTB<sub>4</sub> was less active. The guinea-pig ileum either in segments or in strips of longitudinal muscles responded well to LTC<sub>4</sub>, LTD<sub>4</sub> and histamine but not to LTA<sub>4</sub> and LTB<sub>4</sub>. Rat and rabbit lung parenchymal strip showed very little sensitivity for leukotrienes whereas human parenchymal strips and bronchi were nearly as sensitive as the guinea-pig lung.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 4","pages":"Pages 327-340"},"PeriodicalIF":0.0000,"publicationDate":"1981-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90137-3","citationCount":"90","resultStr":"{\"title\":\"Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles\",\"authors\":\"P. Sirois , S. Roy , J.P. Tétrault , P. Borgeat , S. Picard , E.J. Corey\",\"doi\":\"10.1016/0161-4630(81)90137-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The myotropic activity of leukotrienes A <sub>4</sub>, B<sub>4</sub>, C<sub>4</sub>, D<sub>4</sub> and histamine has been evaluated on selected smooth muscle preparations. LTA<sub>4</sub>, B<sub>4</sub>, C<sub>4</sub> and D<sub>4</sub> were several times more potent than histamine on the guinea-pig lung parenchymal strip, while on the guinea-pig trachea, LTB<sub>4</sub> was less active. The guinea-pig ileum either in segments or in strips of longitudinal muscles responded well to LTC<sub>4</sub>, LTD<sub>4</sub> and histamine but not to LTA<sub>4</sub> and LTB<sub>4</sub>. Rat and rabbit lung parenchymal strip showed very little sensitivity for leukotrienes whereas human parenchymal strips and bronchi were nearly as sensitive as the guinea-pig lung.</p></div>\",\"PeriodicalId\":76381,\"journal\":{\"name\":\"Prostaglandins and medicine\",\"volume\":\"7 4\",\"pages\":\"Pages 327-340\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-4630(81)90137-3\",\"citationCount\":\"90\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161463081901373\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161463081901373","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles
The myotropic activity of leukotrienes A 4, B4, C4, D4 and histamine has been evaluated on selected smooth muscle preparations. LTA4, B4, C4 and D4 were several times more potent than histamine on the guinea-pig lung parenchymal strip, while on the guinea-pig trachea, LTB4 was less active. The guinea-pig ileum either in segments or in strips of longitudinal muscles responded well to LTC4, LTD4 and histamine but not to LTA4 and LTB4. Rat and rabbit lung parenchymal strip showed very little sensitivity for leukotrienes whereas human parenchymal strips and bronchi were nearly as sensitive as the guinea-pig lung.
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