Advances in Traditional Medicine最新文献_第7页

Spondias mombin: biosafety and GC–MS analysis of anti-viral compounds from crude leaf extracts 海绵藻叶提取物抗病毒化合物的生物安全性和GC–MS分析

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-09-07 DOI: 10.1007/s13596-023-00698-y

Akwasi Boadu, Rajshekhar Karpoormath, Manimbulu Nlooto

{"title":"Spondias mombin: biosafety and GC–MS analysis of anti-viral compounds from crude leaf extracts","authors":"Akwasi Boadu, Rajshekhar Karpoormath, Manimbulu Nlooto","doi":"10.1007/s13596-023-00698-y","DOIUrl":"10.1007/s13596-023-00698-y","url":null,"abstract":"<div><p>Essential oils are combinations of naturally occurring phytochemicals that, alone or in synergy with other compounds, can therapeutically attenuate disease-causing viral infections such as SARS-CoV-2, Ebola, and Marburg viruses. This study aimed to investigate the biosafety of and identification of antiviral phytochemicals of <i>Spondias mombin</i> (Linn) leaf crude extracts by GC–MS analysis. GC–MS analysis showed that the compound concentrations were dependent on the polarity of extracting solvent SMH (34), SMDCM (36), SMEA (12), SME (50) and SMM (36). Toluene (15.13%) and di-isooctyl phthalate (14.21%) were identified as the basic constituents of SMH. In SMDCM, n-nonadecanol-1 (19.64%) and eicosane (13.93%) were the main compounds, while in SMEA it was ethanol, 2-butoxy-(83.29%). Both SME and SMM showed the presence of Tetradecyl trifluoroacetate (15.43%). Pentadecanoic acid (12.18%), Propane, 2,2-diethoxy- (33.83%) and o-Xylene (15.87%). The identified antiviral compounds in the crude extracts, were <span>d</span>-Limonene (1.33%), p-Cymene (1.31%), Thymol (0.50%) and Carvacrol (0.87%) in SMM and SMH extracts, with Phytol, acetate being a common constituent in all the essential oils, except SMEA. In vitro cytotoxicity studies of crude <i>S. mombin</i> leaf extracts were performed using the MTT method in three cell lines: MCF-7, A-549 and HEK-293, with IC50 values between 15.91 and 178.5 μg/mL. Therefore, the results indicated that crude extracts from <i>S. mombin</i> leafs had low toxicity and could be used safely. Compared with hexane extracts (1), methanol extracts have more compounds with antiviral properties (3) and can be used as reusable therapeutic candidates, natural dietary supplements or in the fight against SARS-CoV-2, Ebola and Marburg viruses. This can be valuable in pharmaceutical preparations of drug candidates for the treatment of these viruses.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"349 - 372"},"PeriodicalIF":1.8,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-023-00698-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43527414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effect of Punica granatum derived antifungals on strains with clinical failure to terbinafine and azoles drugs 石榴源抗真菌药对特比萘芬和唑类药物临床无效菌株的增效作用

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-09-05 DOI: 10.1007/s13596-023-00703-4

Swamini Saini, Mansi Balhara, Debjani Dutta, Surabhi Chaudhuri, Shamik Ghosh, Kabir Sardana

{"title":"Synergistic effect of Punica granatum derived antifungals on strains with clinical failure to terbinafine and azoles drugs","authors":"Swamini Saini, Mansi Balhara, Debjani Dutta, Surabhi Chaudhuri, Shamik Ghosh, Kabir Sardana","doi":"10.1007/s13596-023-00703-4","DOIUrl":"10.1007/s13596-023-00703-4","url":null,"abstract":"<div><p>Dermatomycosis is a commonly occurring widespread superficial fungal infection. The infection is mostly caused by the dermatophytes (e.g., <i>Trichophyton</i> spp.), and yeasts (e.g., <i>Candida</i> spp.). Due to their persistent, recalcitrant nature and treatment failure it has become a worldwide concern. In our study, we have used multidrug-resistant <i>Trichophyton mentagrophytes</i> var. <i>interdigitale</i> clinical isolates for evaluation of the synergistic effect of the plant-based extract with existing drugs. Here, <i>Punica granatum</i> peel (PGP) extracts alone and their combination with existing antifungal drugs (e.g., Ciclopirox olamine, Zinc pyrithione, Ketoconazole, and Fluconazole) were evaluated as an alternative synergistic combination against <i>Trichophyton</i> and <i>Candida </i>species. Synergy had been determined for PGP extract with other antifungals against <i>Candida</i> and <i>Trichophyton</i> species by checkerboard, ZOI (zone of inhibition), and E-test methods respectively. The isolate<i>s</i> exhibited resistance towards some azoles and allylamines. PGP extract alone and in combination with other antifungals had shown, FIC Index from 0.133 to 0.2 against <i>C. albicans</i> strains, 0.2 to 0.5, FIC against <i>T.</i> <i>rubrum</i> strains respectively. E-test also showed 512±0.0 and 341.3±0.0<b>-</b>fold decrease of MIC (minimum inhibitory concentration), against azole-resistant <i>C. albicans</i> MTCC 227 respectively. The study reveals that PGP extract alone and in combination with other antifungals is a promising source of alternative antifungal therapy to minimize the resistance profile.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"335 - 348"},"PeriodicalIF":1.8,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45476740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and clinical application of Xuebijing injection, a traditional Chinese herbal medicine–a systematic review 血必净注射液的作用机制及临床应用系统综述

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-09-01 DOI: 10.1007/s13596-023-00702-5

Mengchi Chen, Wenbo Shu, Jingfeng Zhang, Hongyuan Huang, Jianghua Liu

{"title":"Mechanisms and clinical application of Xuebijing injection, a traditional Chinese herbal medicine–a systematic review","authors":"Mengchi Chen, Wenbo Shu, Jingfeng Zhang, Hongyuan Huang, Jianghua Liu","doi":"10.1007/s13596-023-00702-5","DOIUrl":"10.1007/s13596-023-00702-5","url":null,"abstract":"<div><h3>Introduction</h3><p>Xuebijing injection (XBJ), a traditional Chinese herbal medicine (TCHM), containing five TCM ingredients, is commonly administered intravenously in clinical practice in China. It has been widely used to treat various serious infectious diseases, such as viral pneumonia, bacterial pneumonia, and sepsis. We aimed to summarize the advanced research progress of XBJ in clinical applications and mechanisms, and promote the applications and development of TCHM in clinical practice.</p><h3>Methods</h3><p>In this systematic review, we searched XBJ-related articles from the last 20 years until 2023, and 90 studies were finally included. We reviewed the latest research progress regarding the mechanisms of action of XBJ in clinical applications, transforming the available data into a summarized reference for target/disease specific XBJ mechanisms of action.</p><h3>Results</h3><p>XBJ has exact curative effect in major viral infections or inflammatory diseases. The possible mechanisms of action may include: (1) Exerts antiviral effects by preventing the virus from entering cells, replicating, and releasing through important targets, such as ACE2 and AKT1; (2) Reduces inflammatory factors [(interleukin)IL -2, IL-4, tumor factor α (TNF-α), etc.] and oxidative stress by regulating PI3K-AKT, nuclear factor kappa B(NF-κB), mitogen-activated protein kinase (MAPK), Toll-like receptor and other signaling pathways; (3) Involves in protecting cells, stabilizing hemodynamics, regulating body metabolism and immune function, etc.</p><h3>Conclusion</h3><p>XBJ can act on multiple targets and signaling pathways for antiviral and anti-inflammatory, which has definite curative effect, high safety and few adverse effects, and is worthy of promotion of clinical application.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"403 - 412"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45111058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Carica papaya leaf extract as an future medicine for thrombocytopenia in dengue patients: from traditional to scientific drug discovery 番木瓜叶提取物作为登革热患者血小板减少症未来药物的潜力：从传统药物到科学药物的发现

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-08-25 DOI: 10.1007/s13596-023-00701-6

Dewangga Yudisthira, Fortuna Filly Firdausi, Citra Fadia Alyani, Fahrul Nurkolis, Harun Al Rasyid, Vincentius Mario Yusuf, Nurpudji Astuti Taslim

{"title":"Potential of Carica papaya leaf extract as an future medicine for thrombocytopenia in dengue patients: from traditional to scientific drug discovery","authors":"Dewangga Yudisthira, Fortuna Filly Firdausi, Citra Fadia Alyani, Fahrul Nurkolis, Harun Al Rasyid, Vincentius Mario Yusuf, Nurpudji Astuti Taslim","doi":"10.1007/s13596-023-00701-6","DOIUrl":"10.1007/s13596-023-00701-6","url":null,"abstract":"<div><p>Dengue, widespread mosquito-borne disease, is endangering through thrombocytopenia which is a warning sign. Currently, therapy for thrombocytopenia is platelet transfusion. However, platelet transfusions are still controversial because of their side effects. <i>Carica papaya</i> Leaf Extract (CPLE) has become popular as a herbal medicine which is claimed to accelerate the increase in platelet levels in dengue fever patients. This article aims to review the potential of CPLE as an alternative therapy in order to accelerate clinical improvement in dengue patients, especially in patients with thrombocytopenia. Systematic review was conducted based on PRISMA guidelines using Google Scholar, Science Direct, Hindawi, PubMed, Cochrane, Taylor & Francis, Proquest, and Semantic Scholar databases in the last 10 years. The inclusion criteria follows the PICOS framework and the assessment of the quality of the literature is based on the Risk of Bias 2.0 Tools. A total of 10 valid and reliable articles demonstrated the effectiveness of CPLE increasing platelet levels in dengue fever patients. The duration of hospitalization and the need for platelet transfusions were also significantly lower in patients treated with CPLE than in controls. The use of CPLE has potential as adjuvant therapy in dengue fever patients with thrombocytopenia without causing major side effects.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"389 - 402"},"PeriodicalIF":1.8,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41859896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-tumoral activity of Allium roseum compounds on breast cancer cells MCF7 and MDA-MB231 香葱化合物对乳腺癌细胞MCF7和MDA-MB231的抗肿瘤活性

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-08-22 DOI: 10.1007/s13596-023-00699-x

Yosr Z. Haffani, Khaoula Louati, Elif Kaya Tilki, Naira Ben Mami, Sihem Mbarek, Nizar Ben Halim, Nourhene Boudhrioua, Yusuf Ozturk, Rafika Ben Chaouacha Chekir, Miris Dikmen

{"title":"Anti-tumoral activity of Allium roseum compounds on breast cancer cells MCF7 and MDA-MB231","authors":"Yosr Z. Haffani, Khaoula Louati, Elif Kaya Tilki, Naira Ben Mami, Sihem Mbarek, Nizar Ben Halim, Nourhene Boudhrioua, Yusuf Ozturk, Rafika Ben Chaouacha Chekir, Miris Dikmen","doi":"10.1007/s13596-023-00699-x","DOIUrl":"10.1007/s13596-023-00699-x","url":null,"abstract":"<div><p>Breast cancer is the most common malignancy in women and a main cause of morbidity and mortality worldwide. Two main challenges to the prevention and treatment of breast cancer are first, the high mortality due to limited accesses to the medicines with the low budgets for health; second, the erratic and drug-resistance resulting in adverse reactions to conventional therapies medicines. Alternatively, there is an expansion of medicinal plant-based production to develop anti-cancer drug, which is processed from a medicinal plant grown locally. Tunisian <i>Allium roseum</i> (AR) have received considerable attention and harbours active flavonoid and phenolic compounds, which are known for owning a large variety of biological activities. In this regard this current study was designated to explore the anti-cancer potential of AR ingredient. The AR ingredient was found cytotoxic on human breast cancer cell lines MCF7 (IC<sub>50</sub> = 3.936 10<sup>–4</sup> g/ml) and MDA-MB231 (IC<sub>50</sub> = 3.052 10<sup>–4</sup> g/ml). Interestingly, AR abolished the cell migration and reduced the invasion of the breast cancer cell lines. However, the proliferation was strongly delayed for MCF7 than MDA-MB231 with cell index values of 0.12 and 1.32, respectively. The AR functional ingredient is harbouring seven major flavonoid and phenolic components, which were used to test their anti-tumoral potential. These results bring additional evidence that AR, as herbal bioresources have strong antitumor potential agent against breast carcinogenesis. Hence, discoveries related to personalized herbal medicine beneficiates the precision medicine.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"323 - 333"},"PeriodicalIF":1.8,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47291553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the polypharmacology mechanistic role of steroidal scaffolds from Spondia mombin L. (Anacardiaceae) on EGFR, VEGF, and mTOR: validation of usage in colorectal cancer management in Southwestern Nigeria 揭示Spondia mombin L.（Anacardiaceae）甾体支架对EGFR、VEGF和mTOR的多药物机制作用：尼日利亚西南部结直肠癌癌症治疗使用的验证

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-08-19 DOI: 10.1007/s13596-023-00700-7

Adedokun Oluwasegun, Ume Ogochukwu, Ogunniran Olusewa

{"title":"Unveiling the polypharmacology mechanistic role of steroidal scaffolds from Spondia mombin L. (Anacardiaceae) on EGFR, VEGF, and mTOR: validation of usage in colorectal cancer management in Southwestern Nigeria","authors":"Adedokun Oluwasegun, Ume Ogochukwu, Ogunniran Olusewa","doi":"10.1007/s13596-023-00700-7","DOIUrl":"10.1007/s13596-023-00700-7","url":null,"abstract":"<div><p>Natural products in conjunction with computer-aided drug design have made a significant impact in the development of novel therapeutics in a fast manner in modern-day drug discovery. <i>Spondia mombin</i> has been reported among locals to be effective in the management of colon cancer. Hence, this study was conducted to experimentally justify the anti-tumor properties of <i>Spondia mombin</i> amongst locals using the combination of benchtop cytotoxicity [<i>Ranicep ranninus</i> (RR) and <i>Saccharomyces cerevisiae</i> (SC)] and human HCT 116 colon cancer cell line (Sulfordiamine B assay) as well as computational chemistry models. The crude extract (CSM) and an aqueous fraction of <i>S. mombin</i> (ASM) at 20–100 µg/mL showed 80–100% mortality of RR, while 7.81–250 µg/mL of CSM and ASM also exhibited 70–95% cytotoxic effect of SC. A 2.02% increase in cytotoxic effect on colorectal cancer cell line (human HCT 116) was observed in ASM (IC<sub>50</sub>—22.23 ± 2.56 µg/mL) relative to 21.78 ± 2.98 µg/mL observed in CSM. Gramisterol, campesterol, chalinasterol, obtusifoliol, beta-sitosterol, stigmasterol, and betulin isolated from CSM (from literature) were shown to possess steroidal scaffold, they were observed to show promising anti-colon cancer properties via antagonistic influence on epidermal growth factor receptor, vascular endothelial growth factor receptor, and mammalian target of rapamycin colon receptors through van der Waal, alkyl, carbon-hydrogen, conventional hydrogen, and pi-alkyl interactions with the amino acid residues in the binding sites of the receptors. Findings from this research experimentally justify the ethnopharmacological claim of <i>S. mombin</i> in the treatment of colon cancer via antagonist polypharmacological action of the steroidal compounds on different receptors implicated in colon cancer carcinogenesis.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"305 - 322"},"PeriodicalIF":1.8,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43418126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV 研究大麻（Bhang）抗HIV治疗潜力的计算机方法

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-08-04 DOI: 10.1007/s13596-023-00697-z

Versha Kajal, Sanjit Boora, Sapna Wadhwa, Kumari Soniya, Suman Yadav, Sulochana Kaushik, Samander Kaushik

{"title":"In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV","authors":"Versha Kajal, Sanjit Boora, Sapna Wadhwa, Kumari Soniya, Suman Yadav, Sulochana Kaushik, Samander Kaushik","doi":"10.1007/s13596-023-00697-z","DOIUrl":"10.1007/s13596-023-00697-z","url":null,"abstract":"<div><p>Human Immunodeficiency Virus (HIV) is one of the world's most significant public health issues. HIV become severe in the COVID pandemic. Scientists are investigating antivirals for HIV from phytoconstituents. Since the beginning of civilization, medicinal plants have played an important role in plentiful sources of nutrients and, healing of infection. The purpose of this in-silico study was to investigate the potential antiviral activity of metabolites from <i>Cannabis sativa</i> against HIV. The plant's active metabolites were retrieved, and molecular docking for 24 molecules was performed against the Protease, GP120, Integrase, and Reverse transcriptase proteins of the HIV, and their binding affinity compared with the existing drug. Results revealed that delta-cadenine, campestrol, beta-carotene and cannabinol showed the lowest binding energy for the proteins reverse transcriptase, protease, GP120, and Integrase when compared with their reference drugs respectively. Bhang is a potential therapeutic agent and provides alternative treatments to prompt, sensitive, cost-effective management of HIV.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"285 - 303"},"PeriodicalIF":1.8,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42761647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic approaches using natural substances on the streptozotocin-induced animal model of sporadic Alzheimer’s disease: a systematic review 使用天然物质治疗链脲佐菌素诱导的散发性阿尔茨海默病动物模型的方法：系统综述

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-08-04 DOI: 10.1007/s13596-023-00696-0

Vanessa Alexandre-Silva, Gabrielle Christine Pereira, Alessandra Mussi Ribeiro

{"title":"Therapeutic approaches using natural substances on the streptozotocin-induced animal model of sporadic Alzheimer’s disease: a systematic review","authors":"Vanessa Alexandre-Silva, Gabrielle Christine Pereira, Alessandra Mussi Ribeiro","doi":"10.1007/s13596-023-00696-0","DOIUrl":"10.1007/s13596-023-00696-0","url":null,"abstract":"<div><p>With the worldwide increase in life expectancy, cases of Alzheimer’s disease (AD) have also risen. Although new disease-modifying treatments are now available, novel drugs for the pharmacological modulation of AD are still needed. To that end, animal models are widely employed, and one of the used models of AD is the intracerebroventricular Streptozotocin-induced (STZ) animal model of sporadic Alzheimer’s disease. STZ triggers neuroinflammatory and oxidative stress pathways, besides increasing Aβ and hyperphosphorylated tau protein expression, ultimately leading to neurodegeneration and impairments in cognitive function. Regarding drug development, natural substances, such as plant extracts and their isolated bioactive compounds, have shown a myriad of relevant pharmacological properties for AD, such as neuroprotective, anti-inflammatory, and antioxidative activities. Considering that, previous studies have investigated the effects of compounds obtained from plants on the STZ model, and the aim of this systematic review was to collect and discuss the published results. Searching in four different databases, we selected and included seventy studies in this review, and their characteristics, methods, and results were extracted and discussed. The main results showed that natural substances obtained from plants can reverse STZ damage through the modulation of antioxidative, antiapoptotic, and anti-inflammatory pathways, improving cognitive function, especially memory. In conclusion, natural substances are potential candidates for novel drug development for the treatment of AD-related symptoms.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"145 - 169"},"PeriodicalIF":1.8,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41300630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional uses, phytochemical and pharmacological properties of Feretia apodanthera Del. (Rubiaceae): a literature review 茜草科蕨类植物的传统用途、植物化学和药理特性：文献综述

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-07-29 DOI: 10.1007/s13596-023-00695-1

Gniènèfèrètien Nounaféri Awa Silué, Kampadilemba Ouoba, Francis Ngolsu, Salfo Ouedraogo, Gisèle Kouakou-Siransy, Rasmané Semdé

{"title":"Traditional uses, phytochemical and pharmacological properties of Feretia apodanthera Del. (Rubiaceae): a literature review","authors":"Gniènèfèrètien Nounaféri Awa Silué, Kampadilemba Ouoba, Francis Ngolsu, Salfo Ouedraogo, Gisèle Kouakou-Siransy, Rasmané Semdé","doi":"10.1007/s13596-023-00695-1","DOIUrl":"10.1007/s13596-023-00695-1","url":null,"abstract":"<div><p><i>Feretia apodanthera</i> Delile (Rubiaceae) is a plant found mainly in tropical Africa. In this region, the different parts of <i>Feretia apodanthera</i> Delile (roots, bark, leaves, fruits) are used as traditional remedies in human medicine. Its uses are diverse and include infectious, metabolic and neurological diseases. The objective of this review was to explore the pharmacological activities, chemical constitution and to give an overview of the traditional medicinal uses of the plant. A search for relevant articles on the subject was carried out in the Scopus, Science Direct and PubMed bibliographic databases. In traditional medicine, <i>Feretia apodanthera</i> Del. has therapeutic potential for treating various conditions such as malaria, hypertension, diabetes, pain, epilepsy, mental disorders, abdominal pain, wounds, fibroids, urinary tract infections, vomiting, dysentery, headache, constipation, hepatitis, dermatoses. Studies have made it possible to isolate and describe the chemical formula of certain phytochemicals contained in the plant, in particular the iridoid glucosides. <i>Feretia apodanthera</i> Del. extracts have various pharmacological activities such as anti-epileptic, antibacterial, antimalarial, antioxidant and anti-diabetic activity. Regarding toxicity, data are limited so far and studies need to be conducted for a better exploration of it. Although <i>Feretia apodanthera</i> Del. has been used extensively in traditional medicine, there is still a lack of pharmacological studies. Based on the ethnopharmacological data, more chemical and pharmacological studies are needed to refine the knowledge on the active principles underlying the uses of the plant in traditional medicine. Similarly, the toxicological profile of the plant should be clearly established for safe use as a phytomedicine.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"133 - 144"},"PeriodicalIF":1.8,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47647246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the synergistic anti-inflammatory effect of naringin/sulindac for the treatment of osteoarthritis: in vitro and in vivo 体外和体内评价柚皮苷/舒林酸治疗骨关节炎的协同抗炎作用

IF 1.8

Advances in Traditional Medicine Pub Date : 2023-07-25 DOI: 10.1007/s13596-023-00692-4

Zeinab A. Elshahid, Abeer Salama, Shaimaa A. Gouhar

{"title":"Assessment of the synergistic anti-inflammatory effect of naringin/sulindac for the treatment of osteoarthritis: in vitro and in vivo","authors":"Zeinab A. Elshahid, Abeer Salama, Shaimaa A. Gouhar","doi":"10.1007/s13596-023-00692-4","DOIUrl":"10.1007/s13596-023-00692-4","url":null,"abstract":"<div><p>Osteoarthritis is a prevailing form of arthritis that affects more than two hundred million people globally. Current treatments depend mainly on reducing pain and improving movement; however, their adverse effects made their use problematic. Usually, a combination of more than one drug is used to alleviate chronic inflammation. Naringin is a natural plant flavonoid present in fruits and vegetables, having many biological actions as anti-inflammatory, antioxidant and anticarcinogenic actions. In our study, we inspected the anti-inflammatory action of naringin in silico then we evaluated its role individually or in combination with sulindac in vitro on RAW 264.7 cells and in vivo by measuring the levels of most common inflammatory mediators; Tumor Necrosis Factor-alpha (TNF-α), Interlukin-6 (IL-6) and nuclear factor kappa β (NF-κB), and the inflammation related pathway mitogen-activated protein kinases/extracellular signal-regulator Kinase (MAPK/Erk1). We also investigated the wound healing effect, locomotor activity and coordination. Results indicated that the combination of low doses of naringin and sulindac restrained the release of IL-6 and NF-κB by 63% and 56% respectively. The combinative treatment significantly reduced the serum levels of MAPK and Erk1 by 90% and 91% respectively as compared to carrageenan group. Histological analysis revealed a decline of cellular infiltration, development of pannus, damage of bone and cartilage, which ensures the obtained antiarthritic effect of combination, the physical activity improved also. This study disseminates the effectiveness of naringin to enhance the therapeutic efficacy of sulindac in the treatment of osteoarthritis through attenuation of NF-κB levels and suppression of MAPK/Erk1 signaling pathway.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 1","pages":"265 - 283"},"PeriodicalIF":1.8,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41272005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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