Capparis zeylanica 介导的 Ag/ZnO 纳米粒子及其通过细胞核凋亡抗增殖的功效

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
P. Suresh, A. Doss, G. Rajeswari, T. P. Kumari Pushpa Rani, R. P. Praveen Pole, S. Satheesh
{"title":"Capparis zeylanica 介导的 Ag/ZnO 纳米粒子及其通过细胞核凋亡抗增殖的功效","authors":"P. Suresh,&nbsp;A. Doss,&nbsp;G. Rajeswari,&nbsp;T. P. Kumari Pushpa Rani,&nbsp;R. P. Praveen Pole,&nbsp;S. Satheesh","doi":"10.1007/s13596-024-00752-3","DOIUrl":null,"url":null,"abstract":"<div><p>Nanobiotechnology has been emerging as an interesting scientific branch holds its applicability in biology, medicine etc. Exploiting the capacity of biogenic metal nanoparticles in areas like biomedicine and therapeutics with peculiarities such as eco-friendly, cheap and biocompatible, the green synthesized bimetallic nanopaticles, silver-zinc oxide nanopaticles (Ag–ZnO NPs), were chosen to find out their anticancer properties. Herein, the Ag–ZnO NPs were fabricated by using the leaf extract of <i>Capparis zeylanica</i> (<i>C. zeylanica</i>) plant. Further, the Ag–ZnO NPs were subjected to characterization, and they were tested for their anticancer potential on the breast cancer cells, MDA-MB-231.The cell viability study implied that the IC<sub>50</sub> value of MDA-MB-231 cells was 43.46 ± 2.56, achieved at a 10 μg/ml concentration of Ag–ZnO NPs. The NPs-treated cancer cells exhibited the ROS-mediated apoptotic changes that were visualized through fluorescent microscopic images using acridine orange/ethydium bromide (AO/EB) staining, 4′,6-diamidino-2-phenylindole (DAPI), and propidium iodide (PI) staining. The findings of the current study point out that the green Ag–ZnO NPs seem to be an efficient anticancer agent.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Capparis zeylanica-mediated Ag/ZnO nanoparticles and their antiproliferative efficacy via nuclear apoptosis\",\"authors\":\"P. Suresh,&nbsp;A. Doss,&nbsp;G. Rajeswari,&nbsp;T. P. Kumari Pushpa Rani,&nbsp;R. P. Praveen Pole,&nbsp;S. Satheesh\",\"doi\":\"10.1007/s13596-024-00752-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nanobiotechnology has been emerging as an interesting scientific branch holds its applicability in biology, medicine etc. Exploiting the capacity of biogenic metal nanoparticles in areas like biomedicine and therapeutics with peculiarities such as eco-friendly, cheap and biocompatible, the green synthesized bimetallic nanopaticles, silver-zinc oxide nanopaticles (Ag–ZnO NPs), were chosen to find out their anticancer properties. Herein, the Ag–ZnO NPs were fabricated by using the leaf extract of <i>Capparis zeylanica</i> (<i>C. zeylanica</i>) plant. Further, the Ag–ZnO NPs were subjected to characterization, and they were tested for their anticancer potential on the breast cancer cells, MDA-MB-231.The cell viability study implied that the IC<sub>50</sub> value of MDA-MB-231 cells was 43.46 ± 2.56, achieved at a 10 μg/ml concentration of Ag–ZnO NPs. The NPs-treated cancer cells exhibited the ROS-mediated apoptotic changes that were visualized through fluorescent microscopic images using acridine orange/ethydium bromide (AO/EB) staining, 4′,6-diamidino-2-phenylindole (DAPI), and propidium iodide (PI) staining. The findings of the current study point out that the green Ag–ZnO NPs seem to be an efficient anticancer agent.</p></div>\",\"PeriodicalId\":7613,\"journal\":{\"name\":\"Advances in Traditional Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-05-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Traditional Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13596-024-00752-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Traditional Medicine","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s13596-024-00752-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

纳米生物技术已成为一个有趣的科学分支,在生物学、医学等领域具有广泛的应用前景。生物金属纳米颗粒具有生态友好、廉价和生物相容性好等特点,利用生物金属纳米颗粒在生物医学和治疗学等领域的能力,我们选择了绿色合成的双金属纳米颗粒--银-氧化锌纳米颗粒(Ag-ZnO NPs)来研究它们的抗癌特性。在这里,Ag-ZnO NPs 是利用泽兰(Capparis zeylanica)植物的叶提取物制成的。细胞活力研究表明,当 Ag-ZnO NPs 浓度为 10 μg/ml 时,MDA-MB-231 细胞的 IC50 值为 43.46 ± 2.56。利用吖啶橙/溴化乙锭(AO/EB)染色、4′,6-二脒基-2-苯基吲哚(DAPI)和碘化丙啶(PI)染色,通过荧光显微镜图像可观察到经 NPs 处理的癌细胞表现出 ROS 介导的凋亡变化。目前的研究结果表明,绿色 Ag-ZnO NPs 似乎是一种高效的抗癌剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Capparis zeylanica-mediated Ag/ZnO nanoparticles and their antiproliferative efficacy via nuclear apoptosis

Nanobiotechnology has been emerging as an interesting scientific branch holds its applicability in biology, medicine etc. Exploiting the capacity of biogenic metal nanoparticles in areas like biomedicine and therapeutics with peculiarities such as eco-friendly, cheap and biocompatible, the green synthesized bimetallic nanopaticles, silver-zinc oxide nanopaticles (Ag–ZnO NPs), were chosen to find out their anticancer properties. Herein, the Ag–ZnO NPs were fabricated by using the leaf extract of Capparis zeylanica (C. zeylanica) plant. Further, the Ag–ZnO NPs were subjected to characterization, and they were tested for their anticancer potential on the breast cancer cells, MDA-MB-231.The cell viability study implied that the IC50 value of MDA-MB-231 cells was 43.46 ± 2.56, achieved at a 10 μg/ml concentration of Ag–ZnO NPs. The NPs-treated cancer cells exhibited the ROS-mediated apoptotic changes that were visualized through fluorescent microscopic images using acridine orange/ethydium bromide (AO/EB) staining, 4′,6-diamidino-2-phenylindole (DAPI), and propidium iodide (PI) staining. The findings of the current study point out that the green Ag–ZnO NPs seem to be an efficient anticancer agent.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信