Advances in Traditional Medicine最新文献

{"title":"Apigetrin ameliorates psoriatic inflammation and skin barrier dysfunction via NF-κB/STAT3 pathway in epidermal and dermal cell models","authors":"Jung Hyun Lee,&nbsp;Min Ji Kim,&nbsp;Hyung Seo Hwang","doi":"10.1007/s13596-026-00922-5","DOIUrl":"10.1007/s13596-026-00922-5","url":null,"abstract":"<div><p>Apigetrin (7-(β-<span>d</span>-glucopyranosyloxy)-4′,5-dihydroxyflavone) is a phytochemical abundant in chamomile. It exhibits potent biological activities, including anti-inflammatory, pro-autophagic, and anticancer effects, while offering superior solubility. However, until recently, little was known about activity of apigetrin on skin regulation, including its effects on psoriasis. First, we compared the cytotoxicity of apigetrin with other polyphenol compounds, such as quercetin and luteolin, to confirm its excellent safety. Apigetrin downregulated the mRNA of inflammatory cytokines, including interleukin-1α/β (IL-1α/β), IL-6, and C-X-C motif chemokine ligand 8 (CXCL8), in HaCaT keratinocyte cells stimulated with tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ)/IL-17A at nontoxic concentrations. Apigetrin significantly suppressed intracellular signaling factors, such as I kappa B (IκB) and Signal transducer and activator of transcription 3 (STAT3), in a dose-dependent manner. In addition, apigetrin increased the resistance value in a dose-dependent manner in the Transendothelial Electrical Resistance (TEER) assay. It also increased the expression of cornified envelope proteins, such as loricrin (LOR), and significantly inhibited MMP-9 expression, suggesting that it restores the skin barrier. Finally, we found that apigetrin significantly inhibited the expression of IL-1α, IL-6, and C–C motif chemokine ligand 20 (CCL20) as well as MMP-9 mRNA in the dermal fibroblast Hs68 cell model. The above results show apigetrin not only improves the skin barrier of the epidermis but also exhibits excellent anti-inflammatory effects in a dermis cell model.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"579 - 589"},"PeriodicalIF":1.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Antidiabetic and antioxidant effect of methanol extract of edible plant Talinum portulacifolium (Forssk) in Streptozotocin induced diabetic rats","authors":"Nageswara Rao Thalapaneni,&nbsp;Mohana Lakshmi Sabapathi,&nbsp;Faraz Raza Ansari,&nbsp;Subhash C. Mandal","doi":"10.1007/s13596-026-00916-3","DOIUrl":"10.1007/s13596-026-00916-3","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"765 - 765"},"PeriodicalIF":1.4,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Oral administration of betaine ameliorates ethanol-induced gastric injury in rats through its antioxidant effects","authors":"Meejung Ahn,&nbsp;Yoonhyoung Kang,&nbsp;Jihwan Moo,&nbsp;Seungjoon Kim,&nbsp;Changjong Moon,&nbsp;Taekyun Shin","doi":"10.1007/s13596-026-00910-9","DOIUrl":"10.1007/s13596-026-00910-9","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"763 - 764"},"PeriodicalIF":1.4,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porcine placental extract enhances social behavior and alleviates anxiety-like responses in a zebrafish model","authors":"Kazuhiro Shiozaki,&nbsp;Toshiki Hyodo,&nbsp;Eishi Kuroda,&nbsp;Momoko Kawabe,&nbsp;Seiwa Michihara,&nbsp;Shigeki Chiba,&nbsp;Nanami Uto,&nbsp;Haruka Amitani,&nbsp;Hajime Suzuki,&nbsp;Akio Inui","doi":"10.1007/s13596-026-00907-4","DOIUrl":"10.1007/s13596-026-00907-4","url":null,"abstract":"<div><p>The symptoms of mental disorders are diverse, with prominent examples including impaired social behavior and heightened anxiety. This study investigated the effects of porcine placental extract on anxiety-like behavior and sociality in zebrafish, a validated model for neurobehavioral studies. The zebrafish were fed a diet supplemented with 0.12% placental extract for 12 weeks. Behavioral analyses revealed that placenta-treated zebrafish spent significantly more time approaching and interacting with conspecifics in the 3-chamber test, indicating enhanced social behavior. Additionally, in the novel tank test, the placental extract significantly reduced freezing behavior and thigmotaxis, which are behavioral indicators of anxiety. These behavioral changes occurred without alterations in locomotor performance or body size. Gene expression analysis of brain tissue revealed the upregulation of isotocin, homologous to mammalian oxytocin. These results suggest placental extract’s potential to support mental health and social engagement in individuals with emotional disorders and those at risk.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"657 - 667"},"PeriodicalIF":1.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-026-00907-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Expression of Concern: In vitro and in vivo antidiabetic activity of Polyalthia longifolia (Sonner.) Thw. leaves","authors":"Andichettiar Thirumalaisamy Sivashanmugam,&nbsp;Tapan Kumar Chatterje","doi":"10.1007/s13596-026-00904-7","DOIUrl":"10.1007/s13596-026-00904-7","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"761 - 761"},"PeriodicalIF":1.4,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Protective effect of Ficus religiosa (L.) against 3-nitropropionic acid induced Huntington disease","authors":"Jitendra O. Bhangale,&nbsp;Niyati S. Acharya,&nbsp;Sanjeev R. Acharya","doi":"10.1007/s13596-026-00903-8","DOIUrl":"10.1007/s13596-026-00903-8","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"517 - 517"},"PeriodicalIF":1.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148061004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Hypolipidemic and antioxidant effects of the Methanolic stem bark extract of Anacardium occidentale Linn. In triton-X 100 induced hyperlipidemic rats","authors":"Ogochukwu C. Anyaegbu,&nbsp;Abayomi M. Ajayi,&nbsp;Aduragbenro D. A. Adedapo","doi":"10.1007/s13596-026-00901-w","DOIUrl":"10.1007/s13596-026-00901-w","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"515 - 515"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of nicotine-induced neurobehavioral deficits by methanolic extracts of Drymaria cordata (L.) Willd. ex Schult.: an in silico and in vivo study","authors":"Linda B. Hrangkhol,&nbsp;Meenakshi Bawari","doi":"10.1007/s13596-026-00896-4","DOIUrl":"10.1007/s13596-026-00896-4","url":null,"abstract":"<div><p><i>Drymaria cordata</i> (L.) Willd. ex Schult. (family: Caryophyllaceae) is an ethnomedicinal plant traditionally used by the tribes of the Dima Hasao district of Assam to treat fever, cough, cold, asthma, headache, sinusitis, wounds, joint pain, stomach ulcers, sleep disturbances, hallucinations, and inflammatory conditions. The present study investigated the neuroprotective potential of the methanolic extract of <i>D. cordata</i> (DCME) against nicotine-induced neurotoxicity using <i>both </i>in silico and in vivo approaches. GC–MS profiling identified 49 phytocompounds, indicating the chemical diversity of the extract. Among these, 11 compounds fulfilled SwissADME drug-likeness criteria, and 10 showed acceptable toxicity profiles in ProTox-3. PASS analysis predicted antioxidant, cytoprotective, anti-inflammatory, and neuroprotective properties for the selected phytoconstituents. Molecular docking was performed against four neurorelevant targets: KcsA potassium channel (4UUJ), GABAA β3 receptor (4COF), 5-HT3 receptor (4PIR), and NMDA GluN1b–2B receptor (7TE6). Docking validation yielded RMSD values below 2.0 Å. Among the prioritized ligands, 13-hexyloxacyclotridec-10-en-2-one exhibited the most consistent binding across all targets. In vivo evaluation using Swiss albino mice showed that nicotine administration (14.69 mg/kg) induced anxiety-like behavior, depression-like behavior, locomotor suppression, and memory impairment (<i>p</i> &lt; 0.001). Treatment with DCME (200 and 500 mg/kg) significantly alleviated these effects. The higher dose improved behavioral outcomes in the Elevated Plus Maze, Open Field Test, Forced Swim Test, and Morris Water Maze test (<i>p</i> &lt; 0.001). DCME also reduced lipid peroxidation and restored antioxidant and cholinergic enzyme activities (<i>p</i> &lt; 0.01). Overall, these findings support the traditional use of <i>D. cordata</i> and highlight its potential as a neuroprotective ethnomedicinal agent.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"719 - 744"},"PeriodicalIF":1.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing chitosan nanoparticles as a plant-derived drug carrier for brain tumor prevention and treatment","authors":"Cletus Anes Ukwubile,&nbsp;Ibrahim Iliya,&nbsp;Nnamdi David Menkiti","doi":"10.1007/s13596-026-00900-x","DOIUrl":"10.1007/s13596-026-00900-x","url":null,"abstract":"<div>\u0000 \u0000 <p>Glioblastoma remains one of the most aggressive and treatment-resistant brain tumors, necessitating the development of more effective therapeutic strategies. This study aimed to formulate and evaluate <i>Melastomastrum capitatum</i>-loaded chitosan nanoparticles (MC-CSNPs) as a targeted drug delivery system for glioblastoma treatment. MC-CSNPs were successfully prepared using the ionic gelation method and characterized for physicochemical and biological properties. Among the formulations, F3 exhibited optimal performance with the smallest particle size (202.00 ± 1.15 nm), highest encapsulation efficiency (89.60 ± 0.41%), and favorable zeta potential (+ 25.02 ± 0.1 mV), indicating good stability. FTIR and XRD analyses confirmed successful encapsulation and reduced crystallinity. SEM revealed rough, porous nanoparticles suitable for enhanced drug loading, while MC-CSNPs exhibited a biphasic, sustained drug release profile, with formulation F3 achieving the highest cumulative release (~ 94.8% at 72 h). Drug release followed first-order kinetics, with F3 showing the best fit (R² = 0.989), indicating concentration-dependent and controlled release behavior. Biological evaluations demonstrated that MC-CSNPs significantly reduced brain tumor cell viability (27.60 ± 2.22% at 100 µg/mL) compared to the free extract. Enhanced cellular uptake (67.85 ± 3.52%) and apoptosis induction (72.50 ± 4.21%) further confirmed their superior anticancer activity. In vivo studies showed improved body weight gain and increased apoptotic activity in treated groups, with MC-CSNPs outperforming the free extract. Additionally, MC-CSNPs effectively reduced oxidative stress (ROS: 30.12 ± 1.75), restored mitochondrial membrane potential (ΔΨm: 4.45 ± 0.38), and improved antioxidant enzyme activities. Histopathological analysis revealed significant neuroprotection and reduced tumor-induced damage. Overall, MC-CSNPs demonstrated enhanced therapeutic efficacy through improved drug delivery, increased apoptosis, and reduced oxidative stress, highlighting their potential as a promising nanocarrier system for glioblastoma treatment.</p>\u0000 </div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"449 - 464"},"PeriodicalIF":1.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Histomorphometric and collagen fibers organization in annular punctured induced intervertebral disc degeneration in rabbit model: restorative and antioxidant role of Brassica oleracea","authors":"B. Ogunlade,&nbsp;S. A. Adelakun,&nbsp;B. K. Akinola,&nbsp;O. A. Adedotun","doi":"10.1007/s13596-026-00898-2","DOIUrl":"10.1007/s13596-026-00898-2","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"513 - 513"},"PeriodicalIF":1.3,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148061262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}