Advances in Traditional Medicine最新文献

{"title":"Retraction Note: Anti-diabetic, lipid lowering and antioxidant potential of Girardinia heterophylla in high fat diet and streptozotocin induced diabetic rats","authors":"S. Mohanalakshmi, C. K. Ashok Kumar, R. Jayaraman, M. Pooja","doi":"10.1007/s13596-026-00897-3","DOIUrl":"10.1007/s13596-026-00897-3","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"511 - 511"},"PeriodicalIF":1.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond traditional medicine: Cotinus coggygria Scop. extracts as promising adjuvants in cancer therapy","authors":"Danijela Todorovic,&nbsp;Suzana Popovic,&nbsp;Vasilija Srdanovic,&nbsp;Dejan Baskic,&nbsp;Sanja Matic,&nbsp;Tijana Markovic,&nbsp;Milica Markovic,&nbsp;Ana Todorovic,&nbsp;Andrija Ciric,&nbsp;Nenad Zlatic,&nbsp;Milan Stankovic","doi":"10.1007/s13596-026-00891-9","DOIUrl":"10.1007/s13596-026-00891-9","url":null,"abstract":"<div><p><i>Cotinus coggygria</i> Scop. is traditionally used for its wound-healing, antimicrobial, and anti-inflammatory properties. Many phenolic and flavonoid compounds isolated from this plant have been extensively documented for their anticancer properties; however, data on the antitumor potential of the crude extract and the mechanisms underlying its effects are scarce. The aim of the study was to investigate the antitumor effects of <i>C. coggygria</i> Scop. leaf and bark crude methanol extracts on tumor cell lines. Chemical analysis was performed using HPLC. The cytotoxic effect of extracts against HCT116 and HeLa tumor cell lines and non-transformed MRC-5 cells was estimated using the MTT assay. The type of cell death and the impact on cell cycle progression were assessed by flow cytometry. Wound healing assay was employed for cell migration studies. The nature of interactions with doxorubicin was analysed with the SinergyFinder+ platform. Both extracts exhibited moderate to pronounced and notably selective cytotoxic effects against tumor cells. Extracts induced apoptosis, as evidenced by the change in the Bax/Bcl-2 ratio, mitochondrial damage, activation of caspase-3, and the disruption of cell cycle progression. Both extracts potentiated the cytotoxic effects of doxorubicin and markedly suppressed the migratory capacity of HCT116 and HeLa cells in vitro. The results of the study indicate the potential of <i>C. coggygria</i> Scop. leaf and bark crude extracts as complementary agents in cancer therapy.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"693 - 705"},"PeriodicalIF":1.4,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Expression of Concern: Fructose diet and low dose streptozotocin treatment induces the development of diabetic nephropathy in rats","authors":"Roshni Patel,&nbsp;Palak Shah,&nbsp;Shrikalp Deshpande,&nbsp;Gaurang Shah,&nbsp;Priyanshee Gohil","doi":"10.1007/s13596-026-00890-w","DOIUrl":"10.1007/s13596-026-00890-w","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"507 - 507"},"PeriodicalIF":1.3,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Comparative study of anti-allergic activity of two poly-herbal formulations in ova-challenged allergic rhinitis mice model","authors":"Richa Srivastava,&nbsp;Sajal Srivastava,&nbsp;Satya Prakash Singh","doi":"10.1007/s13596-026-00889-3","DOIUrl":"10.1007/s13596-026-00889-3","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"509 - 509"},"PeriodicalIF":1.3,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical evaluation of the anti-typhoid efficacy and safety of a traditional herbal concoction (P16) from Detarium senegalensis and Cochlospermum tinctorium in rodent models","authors":"Patrick Valere Tsouh Fokou,&nbsp;Julliette Junko Ntishi,&nbsp;Gerald Ngo Teke,&nbsp;Marius Jaures Tsakem Nangap,&nbsp;Manuella Chloe Mouandji,&nbsp;Brice Rostan Pinlap,&nbsp;Lauve Rachel Tchokouaha Yamthe,&nbsp;Issakou Bakarnga-via,&nbsp;Fabrice Fekam Boyom","doi":"10.1007/s13596-026-00888-4","DOIUrl":"10.1007/s13596-026-00888-4","url":null,"abstract":"<div><p>Typhoid fever continues to impose a substantial public health burden globally and particularly in Cameroon, where rising antibiotic resistance significantly complicates treatment. Traditional medicine, often serving as a primary healthcare option in rural regions, offers a potential avenue for alternative therapies. Previous investigations reported the in vitro anti-Salmonella activity of concoction P16, derived from <i>Detarium senegalensis</i> and <i>Cochlospermum tinctorium</i>. The present study was designed to assess the in vivo safety and curative efficacy of this promising P16 concoction in rodent models. The acute oral toxicity of P16 was evaluated in mice following OECD Guideline 423, demonstrating excellent tolerability with a lethal dose 50 (LD₅₀) exceeding 2000 mg/kg body weight, thereby classifying it as low-toxicity. For efficacy assessment, <i>Salmonella typhimurium</i>-infected Wistar rats were orally administered P16 at doses of 75, 150, and 300 mg/kg body weight. P16 treatment significantly reduced the bacterial load within 10 days, leading to complete bacterial clearance from fecal matter. Comprehensive safety assessments, including biochemical, hematological, and histopathological analyses, generally revealed no significant adverse effects on vital organs such as the liver and kidneys or key blood parameters at therapeutic dose. However, localized intestinal edema was observed at the highest dose (300 mg/kg). These findings collectively indicate that concoction P16 possesses significant anti-typhoid activity and a favorable safety profile within the tested therapeutic range in the studied animal models. Further research is imperative to isolate and characterize the active compounds responsible for its therapeutic effects, elucidate their precise mechanisms of action, and develop standardized formulations for potential clinical application.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"745 - 759"},"PeriodicalIF":1.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administration of Humulus scandens extract ameliorates cisplatin-induced muscle atrophy by attenuating inflammatory and oxidative stress responses in mice","authors":"Shi Qi Xu,&nbsp;Wenchao Gong,&nbsp;Jing Li,&nbsp;Wenjie Qin,&nbsp;Yanming Yu,&nbsp;Dong-Hwa Chung,&nbsp;De Xin Dang","doi":"10.1007/s13596-025-00877-z","DOIUrl":"10.1007/s13596-025-00877-z","url":null,"abstract":"<div><p>Cisplatin-related toxic side effects, including muscle atrophy, body weight loss, and anorexia, significantly impair the quality of life in cancer patients. Herbal medicines with antioxidant and anti-inflammatory properties have shown potential to mitigate cisplatin-induced side effects. <i>Humulus scandens</i> (HS), a traditional medicinal plant with strong antioxidant and anti-inflammatory activities, has not yet been investigated for protective effects against cisplatin-induced toxicity. Therefore, we conducted a study to evaluate the effects of HS extract administration on alleviating cisplatin-induced adverse effects in mice. Eighteen healthy male C57BL/6 mice were used in a 35-day experiment. Animals were randomly assigned to three groups: (1) control group, which received only regular drinking water; (2) cisplatin-treated group, which administered with cisplatin (3 mg/kg body weight, intraperitoneally) daily from days 28 to 35 while receiving regular water; and (3) Cis plus HS group, which received the same cisplatin treatment from days 28 to 35 and drinking water supplemented with HS extract (750 mg/kg). The results demonstrated that cisplatin treatment caused marked inflammation and oxidative stress in skeletal muscle tissues. It also decreased appetite, induced muscle atrophy, reduced body weight, and impaired muscle strength. In contrast, HS extract administration partially alleviated these negative effects. Specifically, HS extract administration reduced inflammation and oxidative stress in muscle tissues, attenuated muscle atrophy, and improved muscle strength in mice. In conclusion, these findings suggest that HS extract may serve as a beneficial dietary supplement to alleviate cisplatin-induced muscle atrophy.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"645 - 655"},"PeriodicalIF":1.4,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats","authors":"Mohammad Tarique,&nbsp; Badruddeen,&nbsp;Farogh Ahsan,&nbsp;Juber Akhtar,&nbsp;Mohammad Irfan Khan,&nbsp;Mohammad Khalid","doi":"10.1007/s13596-026-00887-5","DOIUrl":"10.1007/s13596-026-00887-5","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 1","pages":"275 - 275"},"PeriodicalIF":1.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147342712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptolepis sanguinolenta and cryptolepine as dual-action therapeutics: enhancing antimicrobial activity and promoting wound repair","authors":"Ahmed Wahab Obeng,&nbsp;Theresa Appiah Agana,&nbsp;Vivian Etsiapa Boamah,&nbsp;Yaw Duah Boakye,&nbsp;Erdi Can Aytar,&nbsp;Francis Adu,&nbsp;Christian Agyare","doi":"10.1007/s13596-025-00880-4","DOIUrl":"10.1007/s13596-025-00880-4","url":null,"abstract":"<div><p>The study aimed to investigate the wound-healing activity and antimicrobial properties of <i>Cryptolepis sanguinolenta</i> root and its main alkaloid, cryptolepine. <i>C. sanguinolenta</i> was extracted with water, and cryptolepine was isolated from the root of the plant. The antimicrobial properties of <i>C. sanguinolenta</i> and cryptolepine were evaluated against some selected microorganisms. Excision wounds were made on the dorsal area of Sprague-Dawley rats, which were then treated with the prepared aqueous cream formulations containing <i>C. sanguinolenta</i> (2.5%, 5%, and 10% w/w) and cryptolepine (0.1% and 0.3%). Molecular docking was performed to predict the interaction between cryptolepine and test organisms. <i>C. sanguinolenta</i> and cryptolepine increased the sensitivity of the test organisms to the conventional drugs. The time-kill kinetic assay showed that <i>C. sanguinolenta</i> and cryptolepine possessed static activity. Wounds from rats treated with 10% w/w <i>C. sanguinolenta</i> and 0.1% and 0.3% w/w cryptolepine exhibited a significant reduction in wound size over the study period (<i>p</i> &lt; 0.05) compared to untreated wounds. Tissue histology showed no residual inflammation, marked epithelialization and collagen deposition and angiogenesis in 10% w/w <i>C. sanguinolenta</i>-treated wounds, 1% and 0.3% w/w cryptolepine-treated rat wounds. The findings of this study show that <i>C. sanguinolenta</i> and its isolated compound, cryptolepine, possess wound-healing and antimicrobial activity.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"591 - 615"},"PeriodicalIF":1.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Hepatoprotective activity of methanol extract of Litsea glutinosa against hepatotoxin induced toxicity","authors":"Nilanjan Ghosh,&nbsp;Rituparna Chaki,&nbsp;Mahadeb Pal,&nbsp;Subhash C Mandal","doi":"10.1007/s13596-026-00883-9","DOIUrl":"10.1007/s13596-026-00883-9","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 1","pages":"273 - 273"},"PeriodicalIF":1.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147337977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bu-Fei-Kang-Xian decoction regulates JAK2/STAT3 pathway to inhibit cellular senescence ameliorating pulmonary fibrosis","authors":"Yinzhe Gui,&nbsp;Wanchun Zheng,&nbsp;Xiaojing Niu,&nbsp;Weike Li,&nbsp;Ruiyi Chen,&nbsp;Zhiwan Wang","doi":"10.1007/s13596-025-00881-3","DOIUrl":"10.1007/s13596-025-00881-3","url":null,"abstract":"<div><p>Pulmonary fibrosis (PF) remains a devastating condition with no fully satisfactory treatment. Bu-Fei-Kang-Xian Decoction (BFKXD), a traditional Chinese medicine decoction,, has shown promise in improving symptoms in patients with PF; however, its underlying molecular mechanism remains elusive. Cell model was constructed using transforming growth factor-β1 (TGFβ1), and the mouse model was established by bleomycin. CCK-8 was used to assay cell viability, and AGE/sRAGE levels were measured by ELISA. Cellular senescence were expressed using γ-H2AX, SA-β-Gal, SASP and senescence-associated protein. The extent of PF lesions in mice was visualized by H&amp;E and Masson staining. The expression levels of SASP and senescence-associated proteins were used as indicators of cellular senescence in mouse models. In addition, WB was used to detect changes in JAK2/STAT3 expression. Our results demonstrated that TGFβ1 inhibited cell viability, elevated AGEs/sRAGE levels, and promoted γ-H2AX expression in MRC-5 cells. TGFβ1 facilitated the elevation of SASP, induced an elevated rate of SA-β-Gal deposition, and promoted the increased abundance of senescence-associated protein expression in cells. And TGFβ1 promoted elevated activation of JAK2/STAT3. BFKXD reversed the aforementioned results. Moreover, BFKXD alleviated bleomycin-induced lung tissue fibrosis and inhibited lung tissue cellular senescence. In conclusion, our results found BFKXD was able to alleviate PF by reducing cellular senescence through inhibition of JAK2/STAT3, providing theoretical support for the clinical application of BFKXD.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"465 - 474"},"PeriodicalIF":1.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}