Advances in Traditional Medicine最新文献

{"title":"Evaluation of chicory leaf extract on chronic kidney disease model in streptozotocin-induced diabetic nephropathy","authors":"Simran Sultana,&nbsp;Uday Raj Sharma,&nbsp;Reddibathina Leela Haripriya,&nbsp;Athira Ramachandran,&nbsp;Runashree Borah,&nbsp;V. Surendra,&nbsp;T. Haribabu,&nbsp;S. V. Gayathri,&nbsp;Suresh Janadri,&nbsp;P. M. Manjunatha","doi":"10.1007/s13596-023-00724-z","DOIUrl":"10.1007/s13596-023-00724-z","url":null,"abstract":"<div><p>This study aimed to evaluate Chicory leaf extract for its potential activity on CKD model in STZ induced diabetic nephropathy in Wistar albino rats. Diabetic nephropathy was by administering STZ (35 mg/kg) for a period of seven days, which was confirmed by estimating the blood glucose levels (&gt; 250 mg/dl). After the successful model establishment, the rats were allowed a progression period to CKD for 3 weeks and confirmed by estimating the serum creatinine levels. Thereafter, the rats were treated with chicory leaf extract for a period of 6 weeks at the doses 25 mg/kg, 50 mg/kg and 100 mg/kg. Changes in renal function related parameters in serum and urine were estimated along with histopathological studies. CKD rats exhibited renal dysfunction, as evidenced by reduced serum creatinine, increased blood glucose, blood urea nitrogen and proteinuria, along with alterations in the antioxidant parameters like SOD, CAT, GSH and MDA, that were reversed by Chicory leaf extract. Chicory leaf extract was also found to markedly improve the histopathological alteration sin the CKD effected kidneys. Chicory leaf extract was found to be beneficial in rats with chronic kidney disease seen by the reversion of the altered parameters to almost normal range.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 3","pages":"765 - 775"},"PeriodicalIF":1.8,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Elgucare in a rat model of intervertebral disc degeneration","authors":"Ting-Kuo Chang,&nbsp;Yueh-Ching Liu,&nbsp;Tzu-Yun Chien,&nbsp;Yu-Ting Chen,&nbsp;Ching-Chen Chen","doi":"10.1007/s13596-023-00730-1","DOIUrl":"10.1007/s13596-023-00730-1","url":null,"abstract":"<div><p>As an avascular tissue, the intervertebral disc (IVD) faces difficulties in obtaining nutrients and is prone to accumulating metabolic waste. The ensuing IVD degeneration (IVDD) causes symptoms such as low back pain. Traditional Chinese medicine has a millennia-long history of treating IVDD, with the advantages of safety and few adverse effects. Based on prior pharmacological research, the Chinese herbal formula Elgucare is abundant in the nutrients required by the IVD and can improve blood circulation, accelerating the removal of metabolic waste from the IVD. This study used a 23 G needle to surgically induce IVDD in a rat model. Thirty rats were randomly assigned to five groups: one that underwent sham surgery (Sham), one with IVDD that was not fed Elgucare (EGC-0), and three with IVDD that were fed Elgucare at different concentrations for six weeks (EGC-L, EGC-M, and EGC-H). Study parameters, including total body weight, plantar sensitivity to pain, gait analysis, IVD thickness, and IVD morphology, were used to assess the effects of Elgucare on IVDs. Our results showed that administering Elgucare to rats effectively reduced plantar tingling and improved swing speed during gait analysis. Elgucare also accelerated increases in IVD thickness and increased the proportion of IVD that returned to normal cellularity. The possible benefits of Elgucare include alleviating pain, improving mobility, and accelerating IVD repair, indicating its potential for use in IVD therapy.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"607 - 616"},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-023-00730-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corylus jacquemontii Decne.: a promising lesser-known multipurpose tree species of the Himalayan region","authors":"Aradhna Bharti,&nbsp;Sanjay Kr. Uniyal","doi":"10.1007/s13596-023-00729-8","DOIUrl":"10.1007/s13596-023-00729-8","url":null,"abstract":"<div><p>The article presents an overview of Indian hazelnut (<i>Corylus jacquemontii</i>)- a multipurpose threatened species of the Himalayan region of high traditional importance. The species is used as a medicine, fuelwood, fodder, and timber by the resident communities of Himalaya. The edible nuts of the species are nutrient-rich and have a high market value; they are collected and sold by the local people to earn hard cash. Further, a wide range of pharmacological properties that aid in the prevention of cardiovascular diseases, diabetes, and other oxidative stress-related disorders add to the importance of the species. The recent overexploitation for diverse purposes has threatened its survival and calls for multidisciplinary efforts for the conservation of the traditionally important Indian hazelnut.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"651 - 658"},"PeriodicalIF":1.8,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139206238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the anti-diabetic properties of various flavonoids","authors":"Niharika Rasania,&nbsp;Deepti Sharan","doi":"10.1007/s13596-023-00725-y","DOIUrl":"10.1007/s13596-023-00725-y","url":null,"abstract":"<div><p>Natural herbal constituents have been continuously utilised as a source of medicine since ancient times to cure diverse types of disorders that ail human body, like cardiovascular disease (CVDs), diabetes mellitus (DM), bacterial and viral infections. Several studies have recently been conducted on flavonoids derived from various parts of plants, and their diverse functions are being widely explored. Flavonoids are nutraceuticals that have a wide range of biological activities. Their antioxidant properties account for the majority of their protective effects including minimizing oxidative stress and inflammation besides their potential to modulate the activities of enzymes. Flavonoids are also used to manage and treat diabetes, as well as diabetes associated comorbidities. Increased risk of mortality during diabetes and diabetes associated comorbidities like hypertension, stroke, neuropathy, nephropathy etc. are directly related to the elevated glycemic index of diabetics. Here we discuss the importance of flavonoids derived from nature for their medicinal roles, factors leading to the onset of diabetes and its associated complications. Finally, this review discusses the potential role of various flavonoids as an alternative remedial approach to mitigate the condition of diabetes.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"971 - 983"},"PeriodicalIF":1.8,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139209781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight into the ethnopharmacological importance of Indian subcontinent medicinal plant species of Rubiaceae family","authors":"Debajyoti Roy,&nbsp;Seema Brar,&nbsp;Rohit Bhatia,&nbsp;Naresh Kumar Rangra","doi":"10.1007/s13596-023-00714-1","DOIUrl":"10.1007/s13596-023-00714-1","url":null,"abstract":"<div><p>The 611 genera and over 13,100 species that make up the vast family Rubiaceae are primarily found in tropical and warm climates. These species are utilized in the Indian subcontinent as traditional medicines to treat a number of ailments in addition to their decorative properties. It is proof that species like <i>Adina cordifolia</i>, <i>Anthocephalus cadamba</i>, <i>Cinchona officinalis</i>, <i>Coffea arabica, Morinda citrifolia,</i> and <i>Paederia foetida</i> have received a lot of attention; yet, many phytochemicals should still be undiscovered as none of these species have been carefully examined for their phytochemical composition. This review aims to highlight the traditional, pharmacological, botanical, and phytochemistry aspects of medicinal plant species belonging to the Rubiaceae family. The most significant research findings from the last few decades found in books and online databases like SciFinder and Google Scholar are reported in the paper. So far, more than 100 structurally diverse compounds have been identified from the Rubiaceae family, mainly including alkaloids, glycosides, flavonoids, triterpenoids, phenols, and volatile components. The crude extracts and compounds from the Rubiaceae family have been reported to possess broad pharmacological effects including antimalarial, antibacterial, antihypertension, antidiabetic, antioxidant, and anti-inflammatory effects during biological screening using leads provided by traditional healers. However, there is a dearth of research on the discovery of active phytoconstituents that are in charge of the pharmacological actions indicated above. This provides the researcher with a fresh perspective on how to study this family.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"947 - 969"},"PeriodicalIF":1.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139219363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation and in vitro cytotoxicity of Phlogacanthus thyrsiformis (Roxb. Ex Hardw.) Mabb. against Dalton’s Lymphoma Ascites (DLA) cells","authors":"Mary Devi,&nbsp;Akalesh Kumar Verma,&nbsp;Namram Sushindrajit Singh,&nbsp;Jumi Das,&nbsp;Kasturi Dutta,&nbsp;Munmi Gogoi,&nbsp;Diksha Dutta","doi":"10.1007/s13596-023-00731-0","DOIUrl":"10.1007/s13596-023-00731-0","url":null,"abstract":"<div><p><i>Phlogacanthus thyrsiformis</i>, a valuable medicinal plant frequently employed by ethnic communities for various health concerns, has shown potential against cancer cell lines in lab tests. However, its effectiveness against Dalton’s Lymphoma (DL) cells remains unknown. In our current study, we aim to investigate the phytochemical constituents, antioxidant properties, and cytotoxic effects of <i>P. thyrsiformis</i> extract against the DL cell line. Additionally, we studied its apoptotic effects through fluorescent staining and Scanning Electron Micrograph (SEM) studies. The plant extract revealed the presence of various important phytochemicals such as carbohydrates, phenols, polyphenols, flavonoids, tannins, terpenoids, triterpenoids, alkaloids, and saponins in various degrees. The analysis revealed that the total phenol content and total flavonoid content were present in substantial quantities, suggesting a strong correlation with its potent antioxidant abilities and also showing close IC₅₀ with the reference, ascorbic acid. Effective growth inhibition of DL cells was observed at different treatment concentrations without affecting normal cells. The occurrence of such cytotoxic effects could be corroborated to its apoptotic-inducing properties. Apoptotic cell death was observed in a dose-dependent manner and further morphological changes were evidenced through SEM studies. Our study thus substantiates that <i>P. thyrsiformis</i> is a potent plant with a reservoir of active phytochemicals and is a natural source of antitumor agents against DL cells.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"593 - 605"},"PeriodicalIF":1.8,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a new topical cream to psoriasis treatment: randomized clinical trial","authors":"Elizabeth Benites,&nbsp;Esmeralda Carrillo,&nbsp;Martha Heras,&nbsp;Doménica Bourne","doi":"10.1007/s13596-023-00719-w","DOIUrl":"10.1007/s13596-023-00719-w","url":null,"abstract":"<div><p>The aim of this study is to develop a new topical cream for psoriasis and to test its results. Experimental clinical trial. Phase I: hypersensitivity test in 100 healthy volunteers. Phase II: 120 patients, prospective, analytical differential study in hospital. In phase I, 99% health persons did not show any reaction. In phase II, the 120 patients selected in two groups, group A-new cream and group B-corticosteroid, the paired samples calculated T-value in group A was: 19.144 for erythema, 6.725 in infiltrate, 12.475 in desquamation and in pruritus 10.863, PASI 14.662 and BSA 19.083 which are higher than 1.96 the result was 0.000 less than <i>P</i> 0.05 highly significant after treatment group B control group, showed the T values, erythema 7.590, infiltrate 10.573, desquamation 7.311, pruritus 3.615, PASI 2.631, BSA 4.411. The T-values which are higher than 1.96 were 0.000 less than <i>P</i> 0.05 highly significant after treatment. In the Pearson correlation for cases and controls, association values were observed for SBA 0.042 before treatment and 0.008, after treatment, in PASI 0.021, before treatment and 0.008 after treatment. The results examined by hypotheses and cross-tabulations are highly significant in groups A and B separately, and when group A is tested against group B by means of cross-tabulations, they show differences after treatment. In the logarithmic regression for the associated risk factors, the odds ratio values of BMI 1.113&gt;OR 1 and urea 1.439&gt;OR 1. The elevation of these two parameters may affect the exposed group. When comparing the group, A and group B, the symptoms of erythema, infiltrate, desquamation, pruritus, PASI index and SBA were found to decrease with the group A/new cream after treatment. Further studies in larger populations are suggested, the new cream has been shown to reduce the clinical symptoms of psoriasis.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 3","pages":"755 - 764"},"PeriodicalIF":1.8,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-023-00719-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139265857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and evaluation of antiviral plant compounds against respiratory disease-causing viruses: a review","authors":"Thamby Rajah Mahendran,&nbsp;Binsin Cynthia,&nbsp;Ganapaty Manickavasagam,&nbsp;John J. Thambirajah,&nbsp;Maheswaran Solayappan,&nbsp;Thirumalai Komala","doi":"10.1007/s13596-023-00723-0","DOIUrl":"10.1007/s13596-023-00723-0","url":null,"abstract":"<div><p>Influenza viruses are major concern worldwide due to their fast ability to spread, and causing the respiratory illness of varying severity. The rate of travel, urbanization and socializing among the people are the major factors for the spread. The coronaviruses causing the contagious respiratory illness are similar to influenza viruses. The ongoing COVID-19 pandemic serves as an example on how a single influenza virus can greatly disrupt the economy and social activity worldwide on unprecedented scale. The emergence of the new variants also presents threat for the development of drugs and/or vaccines for the treatment of viral infection. Hence, researchers worldwide have been focusing into plant compounds to identify effective bioactive compound which could be developed into therapeutic antiviral drugs against influenza viruses and coronaviruses. The aim of this paper is to summarize the bioactive compounds isolated from plants that exhibit potential against influenza viruses and coronaviruses. This paper also investigates the techniques used in isolation, characterisation and elucidation of antiviral activity of plant compounds in the evaluation and application of such compounds for therapeutic purpose.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 3","pages":"725 - 753"},"PeriodicalIF":1.8,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139269295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of combined ginger and pumpkin seed extracts on cyclophosphamide-induced hepatotoxicity in rats","authors":"Hamed Haddad Kashani,&nbsp;Maryam Taheri,&nbsp;Zeinab Qotbi,&nbsp;Abolfazl Zahedi,&nbsp;Fatemeh Izadpanah,&nbsp;Hossein Nikzad","doi":"10.1007/s13596-023-00721-2","DOIUrl":"10.1007/s13596-023-00721-2","url":null,"abstract":"<div><p>Cyclophosphamide is an alkylating agent that is widely used in cancer therapy. An important complication of this drug is hepatotoxicity. The hepatic prophylactic effects of ginger and pumpkin seeds were observed due to antioxidant effect. In the current study, the effects of ginger, pumpkin seed extracts, and their combination on cyclophosphamide-induced hepatotoxicity in rats were investigated. In this intervention study, a total of 70 male rats were randomly divided into 10 groups. The blood was taken after 2 weeks of treatment. Liver enzyme levels including ALT, AST and MDA were measured. Sections of the livers of all groups were provided and then histologically evaluated. The data obtained were analyzed using SPSS software version 16. A significant increase in liver enzymes was observed in rats treated with cyclophosphamide compared to other groups. Liver enzyme levels were decreased in rats treated with ginger, pumpkin seed and combined extracts (<i>P</i> &lt; 0.05). Histological examination of liver samples treated with ginger, pumpkin seeds and combined extracts showed a significant reduction in liver damage compared to the cyclophosphamide-treated group (<i>P</i> &lt; 0.05). Ginger, pumpkin seeds and combined extracts could improve biochemical parameters such as AST and ALT and pathological damage in the liver of cyclophosphamide-treated rats.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"583 - 591"},"PeriodicalIF":1.8,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the bioactivity and toxicity of Siparuna guianensis Aublet (Siparunaceae) leaf extracts in zebrafish","authors":"Maria de Fátima Santos,&nbsp;William Franco Carneiro,&nbsp;Bárbara do Carmo Rodrigues Virote,&nbsp;Kiara Cândido Duarte da Silva,&nbsp;Tassia Flavia Dias Castro,&nbsp;Aline Pereira Coli,&nbsp;Luis David Solis Murgas,&nbsp;Marcos Ferrante,&nbsp;Manuel Losada Gavilanes,&nbsp;Elisangela Elena Nunes Carvalho","doi":"10.1007/s13596-023-00722-1","DOIUrl":"10.1007/s13596-023-00722-1","url":null,"abstract":"<div><p><i>Siparuna guianensis</i>, a traditionally utilized aromatic plant known as negramina, is recognized for its anti-inflammatory, analgesic, and antipyretic properties. The present study explores the toxicity, neutrophil migration, tail fin regeneration, and antioxidant effects of various <i>S</i>. <i>guianensis</i> leaf extracts on zebrafish embryos and larvae. Methanol (ME), 70% ethyl alcohol (HE), and distilled water (AE) were used to prepare extracts from the leaves, and the presence of phenolic compounds was confirmed. Additionally, the antioxidant activity index (AAI) was evaluated. Using a zebrafish model, toxicity and teratogenicity were assessed over a 120-h period with concentrations varying from 0.08 to 10 mg/ml. Non-lethal concentrations were used to study neutrophil migration, tail fin regeneration, cell apoptosis, and antioxidant enzyme activity, which included enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST). The extracts, which exhibited high AAI values, were found to contain phenolic compounds. AE proved toxic at concentrations from 2.5 to 10 mg/ml, whereas HE and ME showed toxicity at concentrations between 0.62 and 10 mg/ml. Interestingly, AE-treated larvae did not show any malformations. Despite a reduction in neutrophil migration observed with all tested extracts, they did not promote fin regeneration. The activity of SOD and CAT enzymes remained unaffected by the extracts. Unlike HE and ME, AE did not induce apoptosis in cells. In summary, the leaf extracts of <i>S</i>. <i>guianensis</i> (AE, HE, ME) are rich in phenolic compounds, demonstrate a reduction in neutrophil migration, and possess high AAI values.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"569 - 582"},"PeriodicalIF":1.8,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}