Advances in Traditional Medicine最新文献

{"title":"Gastroprotective and ulcer healing potentials of Nigerian Bee Propolis flavonoid extract on acetic acid-induced gastric ulcers in albino rats (Wistar Strains)","authors":"Noah Segun Oyetayo,&nbsp;Dorcas Oyueley Kodie,&nbsp;Martins I. Nwakasi,&nbsp;Oladapo O. Afolabi,&nbsp;Theophilus A. Jarikre,&nbsp;Oghenemega David Eyarefe,&nbsp;Benjamin O. Emikpe","doi":"10.1007/s13596-022-00674-y","DOIUrl":"10.1007/s13596-022-00674-y","url":null,"abstract":"<div><p>Gastric ulcer is a serious global health challenge, and various natural products are being investigated to prevent and manage the condition. This study evaluated the gastroprotective and ulcer healing potentials of Nigerian bee propolis flavonoid-rich extract (NPE) on acetic acid-induced gastric ulcers in albino rats. Sixty adult male albino rats (222 ± 6.4 g) randomised into 5 groups (<i>n</i> = 12) were studied. Group A (SHAM) was left untreated, while gastric ulcer was induced in groups B (NPE), C (omeprazole) and D (saline). Group E (PRPE) was pre-treated with NPE prior to ulcer induction. The rate of ulcer contraction, volume and pH of gastric juice, and histopathological parameters were evaluated. The results showed a significantly higher rate of contraction (<i>P</i> = 0.001) between days 9 and 12 (NPE &gt; OME &gt; PRPE &gt; SAL) and a significant decrease (<i>P</i> = 0.003) in the volume of gastric juice between days 9 and 12 (NPE &lt; OME &lt; PRPE). Gradual increase in pH was observed in all the groups from days 3 to 12, with a significantly higher rate (<i>P</i> &lt; 0.001) between day 6 and 12 (SHAM &gt; NPE &gt; OME &gt; PRPE &gt; SAL). Histological evaluation showed significantly high neutrophils and macrophages on day 6 (<i>P</i> = 0.006) and lymphocytes (<i>P</i> = 0.004) between day 6 and 12 in the OME and NPE groups. NPE showed gastroprotective and ulcer healing properties by inhibiting ulcer formation and facilitating the curation of induced ulcers and is, therefore, a valuable alternative to conventional gastric ulcer therapy, especially in poor resource settings.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43735697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A versatile untargeted metabolomics-driven technology for rapid phytochemical profiling of stem barks of Zanthoxylum species with antioxidant and antimicrobial activities","authors":"Magrate M. Kaigongi,&nbsp;Catherine W. Lukhoba,&nbsp;Fredrick M. Musila,&nbsp;Malcolm Taylor,&nbsp;Regina W. Mbugua,&nbsp;Joseph Githiomi,&nbsp;Abiy Yenesew,&nbsp;Nokwanda P. Makunga","doi":"10.1007/s13596-022-00676-w","DOIUrl":"10.1007/s13596-022-00676-w","url":null,"abstract":"<div><p><i>Zanthoxylum</i> species are credited with various uses in ethnomedicine due to their rich metabolite composition. In Kenya, these include management of cancer and microbial related ailments. However, there are limited reports showing how the bioactivity of Kenyan <i>Zanthoxylum</i> species is linked to their phytochemical profiles. This study therefore aimed at examining the chemical variation among five <i>Zanthoxylum</i> species found in Kenya (<i>Z. chalybeum, Z. gilletii, Z. holtzianum, Z. paracanthum</i> and <i>Z. usambarense</i>) using metabolomics approaches and the anti-oxidant and antimicrobial activities of these species. In a Folin–Ciocalteu test, the phenolic content of the stem bark extracts of these species were 73.083–145.272 mg TAE/g, while the alkaloids (in bromothymol blue chromogenic test) and flavonoids (in aluminium chloride test) were found to be 152.39–207.19 mg ME/g, and 109.416–186.413 mg CE/g, respectively. These extracts also exerted strong antioxidant activities in the 2,2-iphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power assays. In a broth dilution assay, the extract of the stem bark of <i>Z. holtzianum</i> ability showed the highest antimicrobial activity, followed by <i>Z. chalybeum</i> stem bark extract. The activities were positively correlated to both flavonoids and alkaloids concentrations, while the concentration of phenolics had weak negative correlation to antimicrobial activities. A chemometric analysis of the liquid-chromatography mass spectrometry profiles led to grouping of the species into three clusters. This study illustrates the variation in the bioactivity of <i>Zanthoxylum</i> species based on metabolite composition and justifies the wide usage of <i>Zanthoxylum</i> species in Kenyan traditional medicinal practices.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-022-00676-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46313276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of hyper and hypothermic application revulsively on range of motion, symptom score and quality of life in patients with cervical spondylosis: a randomized controlled trial","authors":"K. J. Sujatha,&nbsp;N. K. Manjunath","doi":"10.1007/s13596-022-00673-z","DOIUrl":"10.1007/s13596-022-00673-z","url":null,"abstract":"<div><p>Cervical spondylosis (CS) is a degenerative age-related disorder affecting the cervical region of the spinal cord which manifests mainly with radiating pain in the neck, numbness in fingers, and headache. To control the symptoms and manage the disease progression, a combination of Complementary and Alternative Medicine with conventional management is necessary. Hence this study is aimed to evaluate the effect of Revulsive Compress (RC) along with the Integrated Naturopathy and Yoga (INY) approach in patients with CS. Out of 210 subjects screened, 60 subjects between the ages of 40 to 85 years were selected for the study. The subjects were randomly assigned into two groups, Group 1 (n = 30) Case group taking RC with INY and Group 2 (n = 30) control group taking only INY protocol for 10 days. Pain, Symptom score, Range of Motion (ROM), and Quality of life (QOL) were assessed before and after the intervention on the 11th day. The result of this study shows that with 10 days of RC and INY intervention, there was a significant reduction in the pain [Visual analog scale (VAS): <i>p</i> = 0.001] and symptom score [Neck disability index: <i>p</i> = 0.001] when compared to the control group. There was a significant improvement in QOL and ROM. The results of this study show that RC intervention with INY is having a substantial effect on patients with CS. Pain and Symptom score have been reduced significantly with marked improvement in QOL and ROM. Hence, this intervention can be used in the management of patients with CS, either as an individual or accompanied by management.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45685144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetrapleura tetraptera curtails oxidative and proinflammatory biochemical events in lithium-pilocarpine model of status epilepticus","authors":"Comfort O. Oladejo,&nbsp;Omowumi O. Ogundele,&nbsp;Abimbola R. Adeoti,&nbsp;Jesutola R. Atilola,&nbsp;M. Tolulope Olaleye,&nbsp;Afolabi C. Akinmoladun","doi":"10.1007/s13596-022-00675-x","DOIUrl":"10.1007/s13596-022-00675-x","url":null,"abstract":"<div><p><i>Tetrapleura tetraptera</i> Taub. (Fabaceae), commonly known as Aidan is ethnopharmacologically used for the management of health conditions such as diabetes mellitus, leprosy, epilepsy, and stroke in Nigeria. This study evaluated the anti-oxidoinflammatory properties of <i>T. tetraptera</i> methanol leaf extract (TTE) in lithium-pilocarpine-induced status epilepticus in Wistar rats. The extract was phytochemically screened and HPLC fingerprinting was performed. Animals were intraperitoneally administered with 127 mg/kg lithium chloride followed by 25 mg/kg pilocarpine 20 h later to induce status epilepticus. The animals were post treated with 50, 100 and 200 mg/kg TTE with 10 mg/kg valproic acid as the reference standard drug. Phytochemical screening of TTE confirmed the presence of tannins, phenols, alkaloids, terpenoids, flavonoids, saponins, glycosides and steroids. Quantitative phytochemical and antioxidant analyses of the extract indicated significant in vitro antioxidant and radical scavenging activity. HPLC analysis of the extract confirmed the presence of aridanin and polyphenols. TTE ameliorated redox imbalance by increasing markers for oxidative stress such as ferric reducing antioxidant power, glutathione level, catalase, glutathione S-transferase and superoxide dismutase activities. Moreover, TTE ameliorated pro-inflammatory events by reducing the level of the pro-inflammatory mediator nitric oxide, attenuating lipid peroxidation (which produces inflammatory lipid peroxidation-derived aldehydes), and decreasing the activities of xanthine oxidase and lactate dehydrogenase in the brain. These results indicated that the leaf of <i>Tetrapleura tetraptera</i> has therapeutic potential against status epilepticus by reversing oxidoinflammatory events. <i>Tetrapleura tetraptera</i> leaf extracts could be used to produce novel plant-based pharmaceuticals for treating status epilepticus and associated disorders.</p><h3>Graphic abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41523286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anogeissus leiocarpus (DC.) Guill and Perr ameliorates pentylenetetrazole-induced seizure/cognitive impairment in rats via inhibition of oxidative stress","authors":"Hauwa Adamu Audu,&nbsp;Amina Ahmed,&nbsp;Joseph Vandi Zirahei,&nbsp;Nathan Isaac Dibal,&nbsp;Samaila Musa Chiroma","doi":"10.1007/s13596-022-00672-0","DOIUrl":"10.1007/s13596-022-00672-0","url":null,"abstract":"<div><p>The study investigates the role of <i>Anogeissus leiocarpus</i> methanol stem bark extract (ALSE) on seizure, oxidative stress and cognitive performance in pentylenetetrazole (PTZ)-induced epilepsy in rat model. Thirty Wistar rats were allocated into five groups (n = 6). Groups 1 and 2 received normal saline intra-peritoneal (i.p) every day and PTZ (i.p) at 35 mg/kg every other day respectively. Groups 3–5 were given ALSE orally at (250 mg/kg and 500 mg/kg) and Diazepam at 4 mg/kg (i.p) respectively. Groups 3–5 were given PTZ (i.p) at 35 mg/kg every other day for 30 days, 30 min after ALSE and Diazepam administration. The rats were observed for seizure activities and also evaluated for cognitive functions. The rats were euthanized thereafter and the brain histology and oxidative stress biomarkers were evaluated. PTZ induction resulted into increased seizure activities leading to the development of kindling, oxidative stress, cognitive impairment and histological aberration of the hippocampus. However, pretreatment with ALSE decreased seizure activities, reversed oxidative stress and cognitive impairment and preserved hippocampal histology relative to the PTZ alone treated rats. Conclusively, ALSE was found to increase seizure latency, prevented cognitive decline, and decreased seizure activities induced by PTZ-kindling in rats. Additionally, ALSE ameliorates PTZ-induced oxidative stress and histological aberrations of the hippocampus. Hence, this study proposed that ALSE might be a promising tool for ameliorating seizure in epilepsy.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49597960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico elucidation of phytoconstituents against 1LPB protein and anti-dyslipidaemic activity of Psoralea corylifolia Linn leaf extract","authors":"Pushpa A. Karale,&nbsp;Shashikant C. Dhawale,&nbsp;Mahesh A. Karale","doi":"10.1007/s13596-022-00671-1","DOIUrl":"10.1007/s13596-022-00671-1","url":null,"abstract":"<div><p><i>Psoralea corylifolia</i> L. has been used in traditional Chinese and Ayurvedic medicine systems for management of various diseases. The various phytochemical constituents work in orchestric manner to treat diverse illnesses. Current pharmaco-therapies shown beneficiary role in treatment of dyslipidaemia but facing life threatening side effects. The usage of herbs increased worldwide and paves the way for development of pharmaceuticals for hyperlipidemia treatment. The main objective of present work was to investigate anti-hyperlipidemic activity and <i>in-silico</i> pancreatic lipase inhibitory potential of <i>Psoralea corylifolia</i> L. (PC) leaf extract. The existence of several phytoconstituents was confirmed by the chromatographic research and mainly includes the flavonoids and furanocoumarins. All studied phytoconstituents were found to have superior binding affinity than standard orlistat (− 7.1 kcal/mol), with docking score ranges from − 10.6 to − 7.3 kcal/mol. At 200 mg/kg/day the ethanolic leaf extract demonstrated highest lipid lowering action. Ethanolic leaf extract of <i>Psoralea corylifolia</i> revealed evidential antihyperlipidemic potential in a concentration dependent manner (<i>P</i> &lt; 0.01). The serum lipid profile (LDL, VLDL, TG, TC) dropped firmly and HDL elevated in hyperlipidemic rats treated with plant extract compared with the hyperlipidemic group rats (<i>P</i> &lt; 0.01). The hepatic TC and TG abruptly increased in hyperlipidemic rats and significantly reduced in hyperlipidemic rats administered with EPC compared with the control group (<i>P</i> &lt; 0.01). The hyperlipidemic rats treated with atorvastatin and PC at different doses shown evidentiary increase in secretion of TC and TG compared with the hyperlipidemic group rats. The study results proposed that EPC leaf extract demonstrated noteworthy antihyperlipidemic action. The findings of docking study recommend utilization of the best ligands experimentally to develop novel anti-obesity agents.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41257323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional herbal medicine: overview of research indexed in the scopus database","authors":"Hassan Hussein Musa,&nbsp;Taha Hussein Musa,&nbsp;Olayinka Oderinde,&nbsp;Idris Hussein Musa,&nbsp;Omonike Olatokunbo Shonekan,&nbsp;Tosin Yinka Akintunde,&nbsp;Abimbola Kofoworola Onasanya","doi":"10.1007/s13596-022-00670-2","DOIUrl":"10.1007/s13596-022-00670-2","url":null,"abstract":"<div><p>Traditional herbal medicine has been playing an essential role in primary health care globally. The aim of this work is to present an overview of traditional herbal medicine research productivity over the past years. The data was accessed from the Scopus database (www.scopus.com), while VOSviewer.Var1.6.6, Bibliometrix, and R studio were used for further analysis of the obtained data. The results showed that researches on traditional herbal medicine increased annually after 1990, followed by a corresponding increase in global citations during the period, with a total of 22,071 authors contributing to all the publications. Yiling Wang of Shanghai Institute of Drug Control, Shanghai, China was the most productive author (TNP = 303), while Journal of “Evidence-based Complementary and Alternative Medicine”, and “Journal of Ethnopharmacology” were the top ranked journals, respectively. Also, China, Japan, and India were found to be the top Corresponding Author's Countries for researches on traditional herbal medicine, as Beijing University of Chinese Medicine, China Academy of Chinese Medical Sciences and China Medical University were top affiliations. Moreover, National Natural Science Foundation of China, National Key Research and Development Program of China, Ministry of Science and Technology of the People's Republic of China, and Ministry of Science and Technology, Taiwan were top funding agencies, with more than 100 documents. The bibliometric research study has revealed an annual increasing trend in traditional herbal medicine, while also revealing that the topmost ranked authors and funding agencies were from Asia especially China.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42233712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing in vitro and in silico approaches to evaluate anti-influenza virus activity of different Bangladeshi plant extracts","authors":"Md Abu Sayem Khan,&nbsp;Rifat Parveen,&nbsp;Sheikh Ariful Hoque,&nbsp;Md Firoz Ahmed,&nbsp;Abu Shara Shamsur Rouf,&nbsp;Sabita Rezwana Rahman","doi":"10.1007/s13596-022-00669-9","DOIUrl":"10.1007/s13596-022-00669-9","url":null,"abstract":"<div><p>Emergence of antiviral drug resistance in influenza virus remains a major public health concern worldwide. Nowadays, different herbs receive renewed attention because of their enormous antiviral potential. In this study, we investigated the antiviral activity of <i>Camellia sinensis, Persicaria hydropiper, Persicaria orientale</i>, <i>Persicaria lapathifolia, Persicaria stagnina, Mucuna pruriens</i> and <i>Chenopodium album</i> against different influenza strains using both in vitro and in silico approaches. Antiviral effect of plant extracts was evaluated by cytopathic effect (CPE) inhibition assay on influenza infected MDCK (Madin Darby Canine Kidney) cell line. Later, the herb demonstrating antiviral activity was virtually screened for their available bioactive compounds and multiple in silico tools were performed to prioritize and establish these compounds as potential inhibitor. The methanol, but not the n-hexane and ethyl acetate extracts of <i>C. sinensis, P. hydropiper, M. pruriens</i> and <i>C. album</i> exhibited anti-influenza effect with EC₅₀ values within 32–46 µg/ml. Importantly, the extracts remained effective against both amantadine-resistant and -sensitive influenza isolates. The molecular docking analysis showed that flavonoids, steroid and derivatives had strong binding affinity to the target proteins which may remain responsible for the anti-influenza characteristics of plant extracts. Pharmacokinetic properties, bioavailability and drug-likeness score revealed that ferulic acid, sinapic acid, campesterol, cryptomeridiol, eupatin and genistein could be attractive leads as potential influenza inhibitors. Taken together, the botanical ingredients of these herbs could be used as valuable candidates for developing novel therapeutics to control influenza related illnesses.\u0000</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45623881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein nanoparticles as natural drugs carriers for cancer therapy","authors":"Sara Zaher,&nbsp;Mahmoud E. Soliman,&nbsp;Mahmoud Elsabahy,&nbsp;Rania M. Hathout","doi":"10.1007/s13596-022-00668-w","DOIUrl":"10.1007/s13596-022-00668-w","url":null,"abstract":"<div><p>Nanoscale drug carriers are useful in improving the bioavilability, targeting delivery, and controlling the release of the loaded drug. Polymers from natural sources possess favourable properties such as adaptability and safety for usage as nanosized drug delivery carriers and as substitutes of synthetic polymers. The use of a biomaterial imparts special biopharmaceutical characteristics to the formulation and changes the pharmacokinetic and pharmacodynamic profile of the entrapped medication. Proteins appear as promising raw materials in this approach because of their extensive availability from renewable sources, low cost, and ability to be chemically modified, ligand conjugation and degraded into harmless by-products. Furthermore, protein nanocarriers have several benefits, including high drug-binding capability and specific tumour targeting using different ligands. This review discusses the properties of different protein biopolymers such as albumin, gelatin, zein, gliadin, casein, collagen, elastin and whey protein. The study focuses on the most relevant applications of the protein nanoparticles loading agents with antitumeric effect. Furthermore, the review summarises the primary findings of tumour-targeted protein nanoparticles in vitro and in vivo studies.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48575951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical survey and nutritional composition of medicinal plants used for traditional galactagogue practice in Katsina state, Nigeria","authors":"Umar Lawal,&nbsp;Rukayat T. Mohammed,&nbsp;Sani M. Gidado,&nbsp;Sulaiman S. Kankara","doi":"10.1007/s13596-022-00667-x","DOIUrl":"10.1007/s13596-022-00667-x","url":null,"abstract":"<div><p>An ethnobotanical survey was conducted in Katsina state, Northern Nigeria to document medicinal plants commonly used by lactating mothers to boost breast milk production. Two hundred and forty (240) respondents made up of (120) nursing mothers, (60) herbalists and (60) traditional birth attendants were interviewed. Ethnobotanical data was obtained using the structured questionnaire method. Standard procedures were followed to analyse the phyto-chemical, proximate, mineral concentrations and chemical composition of the ethanolic extract of the most cited plants. Forty (40) plant species belonging to 38 genera distributed among 24 families are used as galactagogues in Katsina state, Nigeria. All the plant samples contained alkaloids, cardiac glycosides, flavonoids, saponins, tannins and terpenoids. Anthraquinones were found to be absent in <i>Andropogon gayanus, Moringa oleifera</i> and <i>Pennisetum glaucum</i> while phytosterol was absent in <i>Pennisetum glaucum</i> and <i>Vernonia amygdalina.</i> They were also found to contain nutrient compositions in varying amounts. <i>Crotalaria retusa</i> had the highest moisture (12.80%), crude lipid (13.50%) and crude fibre (21.76%) content. <i>Momordica balsamina</i> has the highest ash (13.76%) content. <i>Pennisetum glaucum</i> had the highest carbohydrate content (76.19%) and energy content (364.95%). Mineral analysis revealed that <i>Andropogon gayanus, Momordica balsamina and Vernonia amygdalina</i> showed equal phosphorus (0.3 ppm) contents. <i>Crotalaria retusa</i> showed the highest chromium (2.59 ppm) and copper (1.31 ppm) content. GC/MS analysis revealed that <i>Momordica balsamina</i> contained 99 phytoconstituents. With only 9,12-Octadecadienoic acid (Z,Z)- identified as the only phytoconstituents showing phytoestrogen activity. The indigenous knowledge about lactating mothers in Katsina state, Nigeria used medicinal plants to boost breast milk production is documented.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-022-00667-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47090349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}