Protective effect of combined ginger and pumpkin seed extracts on cyclophosphamide-induced hepatotoxicity in rats

IF 1.8 Q3 PHARMACOLOGY & PHARMACY

Advances in Traditional Medicine Pub Date : 2023-11-11 DOI:10.1007/s13596-023-00721-2

Hamed Haddad Kashani, Maryam Taheri, Zeinab Qotbi, Abolfazl Zahedi, Fatemeh Izadpanah, Hossein Nikzad

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引用次数: 0

Abstract

Cyclophosphamide is an alkylating agent that is widely used in cancer therapy. An important complication of this drug is hepatotoxicity. The hepatic prophylactic effects of ginger and pumpkin seeds were observed due to antioxidant effect. In the current study, the effects of ginger, pumpkin seed extracts, and their combination on cyclophosphamide-induced hepatotoxicity in rats were investigated. In this intervention study, a total of 70 male rats were randomly divided into 10 groups. The blood was taken after 2 weeks of treatment. Liver enzyme levels including ALT, AST and MDA were measured. Sections of the livers of all groups were provided and then histologically evaluated. The data obtained were analyzed using SPSS software version 16. A significant increase in liver enzymes was observed in rats treated with cyclophosphamide compared to other groups. Liver enzyme levels were decreased in rats treated with ginger, pumpkin seed and combined extracts (P < 0.05). Histological examination of liver samples treated with ginger, pumpkin seeds and combined extracts showed a significant reduction in liver damage compared to the cyclophosphamide-treated group (P < 0.05). Ginger, pumpkin seeds and combined extracts could improve biochemical parameters such as AST and ALT and pathological damage in the liver of cyclophosphamide-treated rats.

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生姜和南瓜籽联合提取物对环磷酰胺诱导的大鼠肝毒性的保护作用

环磷酰胺是一种广泛用于癌症治疗的烷化剂。这种药物的一个重要并发症是肝毒性。生姜和南瓜籽的肝脏预防作用是通过抗氧化作用观察到的。本研究调查了生姜、南瓜籽提取物及其组合对环磷酰胺诱导的大鼠肝毒性的影响。在这项干预研究中，共有 70 只雄性大鼠被随机分为 10 组。治疗 2 周后采血。测量肝酶水平，包括谷丙转氨酶、谷草转氨酶和 MDA。提供所有组的肝脏切片，然后进行组织学评估。获得的数据使用 SPSS 软件 16 版进行分析。与其他组相比，接受环磷酰胺治疗的大鼠肝酶水平明显升高。用生姜、南瓜籽和联合提取物处理的大鼠肝酶水平下降（P < 0.05）。用生姜、南瓜籽和混合提取物处理的肝脏样本的组织学检查显示，与环磷酰胺处理组相比，生姜、南瓜籽和混合提取物处理组的肝脏损伤显著减少（P < 0.05）。生姜、南瓜籽和联合提取物可以改善环磷酰胺治疗大鼠肝脏的生化指标，如 AST 和 ALT，以及病理损伤。

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来源期刊

Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-

CiteScore

4.30

自引率

0.00%

发文量

期刊介绍： Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.