Elgucare 对大鼠椎间盘退化模型的影响

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Ting-Kuo Chang, Yueh-Ching Liu, Tzu-Yun Chien, Yu-Ting Chen, Ching-Chen Chen
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引用次数: 0

摘要

作为一种无血管组织,椎间盘(IVD)难以获得营养,并容易积聚代谢废物。随之而来的椎间盘退变(IVDD)会导致腰痛等症状。中药治疗 IVDD 已有千年历史,具有安全、不良反应少等优点。根据之前的药理研究,中药配方 Elgucare 富含 IVD 所需的营养物质,并能改善血液循环,加速 IVD 代谢废物的清除。本研究使用 23 G 注射针在大鼠模型中诱导 IVDD。30只大鼠被随机分为五组:一组接受假手术(Sham);一组患有IVDD,但未喂食Elgucare(EGC-0);三组患有IVDD,但喂食不同浓度的Elgucare达六周之久(EGC-L、EGC-M和EGC-H)。研究参数包括总重量、足底疼痛敏感度、步态分析、IVD厚度和IVD形态,用于评估Elgucare对IVD的影响。我们的研究结果表明,给大鼠服用 Elgucare 能有效减轻足底刺痛,提高步态分析中的摆动速度。Elgucare 还加速了 IVD 厚度的增加,并提高了 IVD 恢复正常细胞的比例。Elgucare 可能带来的益处包括减轻疼痛、改善活动能力和加速 IVD 修复,这表明它具有用于 IVD 治疗的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of Elgucare in a rat model of intervertebral disc degeneration

As an avascular tissue, the intervertebral disc (IVD) faces difficulties in obtaining nutrients and is prone to accumulating metabolic waste. The ensuing IVD degeneration (IVDD) causes symptoms such as low back pain. Traditional Chinese medicine has a millennia-long history of treating IVDD, with the advantages of safety and few adverse effects. Based on prior pharmacological research, the Chinese herbal formula Elgucare is abundant in the nutrients required by the IVD and can improve blood circulation, accelerating the removal of metabolic waste from the IVD. This study used a 23 G needle to surgically induce IVDD in a rat model. Thirty rats were randomly assigned to five groups: one that underwent sham surgery (Sham), one with IVDD that was not fed Elgucare (EGC-0), and three with IVDD that were fed Elgucare at different concentrations for six weeks (EGC-L, EGC-M, and EGC-H). Study parameters, including total body weight, plantar sensitivity to pain, gait analysis, IVD thickness, and IVD morphology, were used to assess the effects of Elgucare on IVDs. Our results showed that administering Elgucare to rats effectively reduced plantar tingling and improved swing speed during gait analysis. Elgucare also accelerated increases in IVD thickness and increased the proportion of IVD that returned to normal cellularity. The possible benefits of Elgucare include alleviating pain, improving mobility, and accelerating IVD repair, indicating its potential for use in IVD therapy.

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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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