{"title":"Elgucare 对大鼠椎间盘退化模型的影响","authors":"Ting-Kuo Chang, Yueh-Ching Liu, Tzu-Yun Chien, Yu-Ting Chen, Ching-Chen Chen","doi":"10.1007/s13596-023-00730-1","DOIUrl":null,"url":null,"abstract":"<div><p>As an avascular tissue, the intervertebral disc (IVD) faces difficulties in obtaining nutrients and is prone to accumulating metabolic waste. The ensuing IVD degeneration (IVDD) causes symptoms such as low back pain. Traditional Chinese medicine has a millennia-long history of treating IVDD, with the advantages of safety and few adverse effects. Based on prior pharmacological research, the Chinese herbal formula Elgucare is abundant in the nutrients required by the IVD and can improve blood circulation, accelerating the removal of metabolic waste from the IVD. This study used a 23 G needle to surgically induce IVDD in a rat model. Thirty rats were randomly assigned to five groups: one that underwent sham surgery (Sham), one with IVDD that was not fed Elgucare (EGC-0), and three with IVDD that were fed Elgucare at different concentrations for six weeks (EGC-L, EGC-M, and EGC-H). Study parameters, including total body weight, plantar sensitivity to pain, gait analysis, IVD thickness, and IVD morphology, were used to assess the effects of Elgucare on IVDs. Our results showed that administering Elgucare to rats effectively reduced plantar tingling and improved swing speed during gait analysis. Elgucare also accelerated increases in IVD thickness and increased the proportion of IVD that returned to normal cellularity. The possible benefits of Elgucare include alleviating pain, improving mobility, and accelerating IVD repair, indicating its potential for use in IVD therapy.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"607 - 616"},"PeriodicalIF":1.8000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-023-00730-1.pdf","citationCount":"0","resultStr":"{\"title\":\"The effects of Elgucare in a rat model of intervertebral disc degeneration\",\"authors\":\"Ting-Kuo Chang, Yueh-Ching Liu, Tzu-Yun Chien, Yu-Ting Chen, Ching-Chen Chen\",\"doi\":\"10.1007/s13596-023-00730-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>As an avascular tissue, the intervertebral disc (IVD) faces difficulties in obtaining nutrients and is prone to accumulating metabolic waste. The ensuing IVD degeneration (IVDD) causes symptoms such as low back pain. Traditional Chinese medicine has a millennia-long history of treating IVDD, with the advantages of safety and few adverse effects. Based on prior pharmacological research, the Chinese herbal formula Elgucare is abundant in the nutrients required by the IVD and can improve blood circulation, accelerating the removal of metabolic waste from the IVD. This study used a 23 G needle to surgically induce IVDD in a rat model. Thirty rats were randomly assigned to five groups: one that underwent sham surgery (Sham), one with IVDD that was not fed Elgucare (EGC-0), and three with IVDD that were fed Elgucare at different concentrations for six weeks (EGC-L, EGC-M, and EGC-H). Study parameters, including total body weight, plantar sensitivity to pain, gait analysis, IVD thickness, and IVD morphology, were used to assess the effects of Elgucare on IVDs. Our results showed that administering Elgucare to rats effectively reduced plantar tingling and improved swing speed during gait analysis. Elgucare also accelerated increases in IVD thickness and increased the proportion of IVD that returned to normal cellularity. The possible benefits of Elgucare include alleviating pain, improving mobility, and accelerating IVD repair, indicating its potential for use in IVD therapy.</p></div>\",\"PeriodicalId\":7613,\"journal\":{\"name\":\"Advances in Traditional Medicine\",\"volume\":\"24 2\",\"pages\":\"607 - 616\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13596-023-00730-1.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Traditional Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13596-023-00730-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Traditional Medicine","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s13596-023-00730-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
The effects of Elgucare in a rat model of intervertebral disc degeneration
As an avascular tissue, the intervertebral disc (IVD) faces difficulties in obtaining nutrients and is prone to accumulating metabolic waste. The ensuing IVD degeneration (IVDD) causes symptoms such as low back pain. Traditional Chinese medicine has a millennia-long history of treating IVDD, with the advantages of safety and few adverse effects. Based on prior pharmacological research, the Chinese herbal formula Elgucare is abundant in the nutrients required by the IVD and can improve blood circulation, accelerating the removal of metabolic waste from the IVD. This study used a 23 G needle to surgically induce IVDD in a rat model. Thirty rats were randomly assigned to five groups: one that underwent sham surgery (Sham), one with IVDD that was not fed Elgucare (EGC-0), and three with IVDD that were fed Elgucare at different concentrations for six weeks (EGC-L, EGC-M, and EGC-H). Study parameters, including total body weight, plantar sensitivity to pain, gait analysis, IVD thickness, and IVD morphology, were used to assess the effects of Elgucare on IVDs. Our results showed that administering Elgucare to rats effectively reduced plantar tingling and improved swing speed during gait analysis. Elgucare also accelerated increases in IVD thickness and increased the proportion of IVD that returned to normal cellularity. The possible benefits of Elgucare include alleviating pain, improving mobility, and accelerating IVD repair, indicating its potential for use in IVD therapy.
期刊介绍:
Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.